CN116018343A - 一种吡啶并嘧啶化合物的晶型 - Google Patents
一种吡啶并嘧啶化合物的晶型 Download PDFInfo
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- CN116018343A CN116018343A CN202180044143.0A CN202180044143A CN116018343A CN 116018343 A CN116018343 A CN 116018343A CN 202180044143 A CN202180044143 A CN 202180044143A CN 116018343 A CN116018343 A CN 116018343A
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- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
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- A—HUMAN NECESSITIES
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- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
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Abstract
本发明公开了一种吡啶并嘧啶的晶型及其制备方法，还包括所述晶型在制备治疗癌症药物中的应用。
Description
PCT国内申请，说明书已公开。
Claims (35)
- PCT国内申请，权利要求书已公开。
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNPCT/CN2020/112863 | 2020-09-01 | ||
| CN2020112863 | 2020-09-01 | ||
| PCT/CN2021/115784 WO2022048545A1 (zh) | 2020-09-01 | 2021-08-31 | 一种吡啶并嘧啶化合物的晶型 |
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| Publication Number | Publication Date |
|---|---|
| CN116018343A true CN116018343A (zh) | 2023-04-25 |
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|---|---|---|---|
| CN202180044143.0A Pending CN116018343A (zh) | 2020-09-01 | 2021-08-31 | 一种吡啶并嘧啶化合物的晶型 |
Country Status (2)
| Country | Link |
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| CN (1) | CN116018343A (zh) |
| WO (1) | WO2022048545A1 (zh) |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2024102421A2 (en) | 2022-11-09 | 2024-05-16 | Revolution Medicines, Inc. | Compounds, complexes, and methods for their preparation and of their use |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN110036010A (zh) * | 2016-09-29 | 2019-07-19 | 亚瑞克西斯制药公司 | Kras g12c突变蛋白的抑制剂 |
| WO2019141250A1 (zh) * | 2018-01-19 | 2019-07-25 | 南京明德新药研发股份有限公司 | 作为krasg12c突变蛋白抑制剂的吡啶酮并嘧啶类衍生物 |
-
2021
- 2021-08-31 WO PCT/CN2021/115784 patent/WO2022048545A1/zh active Application Filing
- 2021-08-31 CN CN202180044143.0A patent/CN116018343A/zh active Pending
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN110036010A (zh) * | 2016-09-29 | 2019-07-19 | 亚瑞克西斯制药公司 | Kras g12c突变蛋白的抑制剂 |
| WO2019141250A1 (zh) * | 2018-01-19 | 2019-07-25 | 南京明德新药研发股份有限公司 | 作为krasg12c突变蛋白抑制剂的吡啶酮并嘧啶类衍生物 |
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| WO2022048545A1 (zh) | 2022-03-10 |
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