CN114728957A - 一种atr抑制剂的晶型及其应用 - Google Patents
一种atr抑制剂的晶型及其应用 Download PDFInfo
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- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
- A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
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- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
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Abstract
一种ATR抑制剂的晶型及其制备方法和在制备治疗与ATR相关疾病的药物的应用。(I)
Description
PCT国内申请，说明书已公开。
Claims (22)
- PCT国内申请，权利要求书已公开。
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2019107221027 | 2019-08-06 | ||
| CN201910722102 | 2019-08-06 | ||
| PCT/CN2020/107474 WO2021023272A1 (zh) | 2019-08-06 | 2020-08-06 | 一种atr抑制剂的晶型及其应用 |
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| Publication Number | Publication Date |
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| CN114728957A true CN114728957A (zh) | 2022-07-08 |
| CN114728957B CN114728957B (zh) | 2023-09-22 |
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| CN202080054862.6A Active CN114728957B (zh) | 2019-08-06 | 2020-08-06 | 一种atr抑制剂的晶型及其应用 |
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| Country | Link |
|---|---|
| US (1) | US20220281858A1 (zh) |
| EP (1) | EP4011881A4 (zh) |
| CN (1) | CN114728957B (zh) |
| AU (1) | AU2020325416A1 (zh) |
| BR (1) | BR112022001393A2 (zh) |
| CA (1) | CA3147322C (zh) |
| IL (1) | IL290106A (zh) |
| WO (1) | WO2021023272A1 (zh) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| TWI778366B (zh) * | 2019-06-06 | 2022-09-21 | 中國商北京泰德製藥股份有限公司 | 作為atr激酶抑制劑的2,4,6-三取代的嘧啶化合物 |
| CN116178366A (zh) * | 2021-11-26 | 2023-05-30 | 深圳市瓴方生物医药科技有限公司 | 氟代吡啶并吡咯类化合物的晶型及其制备方法 |
| WO2023242302A1 (en) | 2022-06-15 | 2023-12-21 | Astrazeneca Ab | Combination therapy for treating cancer |
Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101010318A (zh) * | 2004-07-09 | 2007-08-01 | 阿斯利康(瑞典)有限公司 | 作为磷脂酰肌醇(pi)3－激酶抑制剂的2,4,6－三取代的嘧啶及其在癌症治疗中的用途 |
| WO2009093981A1 (en) * | 2008-01-23 | 2009-07-30 | S Bio Pte Ltd | Triazine compounds as kinase inhibitors |
| CN103068391A (zh) * | 2010-06-11 | 2013-04-24 | 阿斯利康(瑞典)有限公司 | 吗啉代嘧啶及其治疗用途 |
| WO2019050889A1 (en) * | 2017-09-08 | 2019-03-14 | Bluevalley Pharmaceutical Llc | SUBSTITUTED PYRROLOPYRIDINES AS ATR INHIBITORS |
| WO2019154365A1 (zh) * | 2018-02-07 | 2019-08-15 | 南京明德新药研发有限公司 | 一种atr抑制剂及其应用 |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP7290627B2 (ja) * | 2017-08-17 | 2023-06-13 | ボード オブ レジェンツ，ザ ユニバーシティ オブ テキサス システム | Ａｔｒキナーゼの複素環式阻害剤 |
-
2020
- 2020-08-06 AU AU2020325416A patent/AU2020325416A1/en active Pending
- 2020-08-06 CN CN202080054862.6A patent/CN114728957B/zh active Active
- 2020-08-06 CA CA3147322A patent/CA3147322C/en active Active
- 2020-08-06 EP EP20851028.9A patent/EP4011881A4/en active Pending
- 2020-08-06 BR BR112022001393A patent/BR112022001393A2/pt unknown
- 2020-08-06 US US17/632,823 patent/US20220281858A1/en active Pending
- 2020-08-06 WO PCT/CN2020/107474 patent/WO2021023272A1/zh active Application Filing
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2022
- 2022-01-25 IL IL290106A patent/IL290106A/en unknown
Patent Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101010318A (zh) * | 2004-07-09 | 2007-08-01 | 阿斯利康(瑞典)有限公司 | 作为磷脂酰肌醇(pi)3－激酶抑制剂的2,4,6－三取代的嘧啶及其在癌症治疗中的用途 |
| WO2009093981A1 (en) * | 2008-01-23 | 2009-07-30 | S Bio Pte Ltd | Triazine compounds as kinase inhibitors |
| CN103068391A (zh) * | 2010-06-11 | 2013-04-24 | 阿斯利康(瑞典)有限公司 | 吗啉代嘧啶及其治疗用途 |
| WO2019050889A1 (en) * | 2017-09-08 | 2019-03-14 | Bluevalley Pharmaceutical Llc | SUBSTITUTED PYRROLOPYRIDINES AS ATR INHIBITORS |
| WO2019154365A1 (zh) * | 2018-02-07 | 2019-08-15 | 南京明德新药研发有限公司 | 一种atr抑制剂及其应用 |
Also Published As
| Publication number | Publication date |
|---|---|
| AU2020325416A1 (en) | 2022-02-03 |
| CN114728957B (zh) | 2023-09-22 |
| CA3147322A1 (en) | 2021-02-11 |
| WO2021023272A1 (zh) | 2021-02-11 |
| JP2022543856A (ja) | 2022-10-14 |
| EP4011881A1 (en) | 2022-06-15 |
| BR112022001393A2 (pt) | 2022-03-22 |
| US20220281858A1 (en) | 2022-09-08 |
| IL290106A (en) | 2022-03-01 |
| EP4011881A4 (en) | 2023-08-09 |
| CA3147322C (en) | 2024-05-21 |
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