CN115996912A - Enpp1的亚氨基硫烷酮抑制剂 - Google Patents

Enpp1的亚氨基硫烷酮抑制剂 Download PDF

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CN115996912A
CN115996912A CN202180045961.2A CN202180045961A CN115996912A CN 115996912 A CN115996912 A CN 115996912A CN 202180045961 A CN202180045961 A CN 202180045961A CN 115996912 A CN115996912 A CN 115996912A
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compound
pharmaceutically acceptable
acceptable salt
mmol
mixture
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Chinese (zh)
Inventor
D·A·柯根
S·贝蒂戈莱
M·苏
P·尼奇波罗维奇
L·凡布鲁克伦
R·福尔默
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Volascha Therapy Co
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Volascha Therapy Co
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    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
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    • A61K31/50—Pyridazines; Hydrogenated pyridazines
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    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
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    • A61K31/541—Non-condensed thiazines containing further heterocyclic rings
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    • C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
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  • Chemical & Material Sciences (AREA)
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  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
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  • Animal Behavior & Ethology (AREA)
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  • Diabetes (AREA)
  • Bioinformatics & Cheminformatics (AREA)
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  • Physical Education & Sports Medicine (AREA)
  • Cardiology (AREA)
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  • Immunology (AREA)
  • Rheumatology (AREA)
  • Endocrinology (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
CN202180045961.2A 2020-05-04 2021-05-03 Enpp1的亚氨基硫烷酮抑制剂 Pending CN115996912A (zh)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US202063019853P 2020-05-04 2020-05-04
US63/019,853 2020-05-04
US202063093709P 2020-10-19 2020-10-19
US63/093,709 2020-10-19
PCT/US2021/030496 WO2021225969A1 (en) 2020-05-04 2021-05-03 Imino sulfanone inhibitors of enpp1

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CN115996912A true CN115996912A (zh) 2023-04-21

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US (1) US11780849B2 (enExample)
EP (1) EP4146344A1 (enExample)
JP (1) JP7781774B2 (enExample)
KR (1) KR20230019431A (enExample)
CN (1) CN115996912A (enExample)
AU (1) AU2021268606A1 (enExample)
CA (1) CA3182410A1 (enExample)
IL (1) IL297929B2 (enExample)
MX (1) MX2022013941A (enExample)
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Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN116348451A (zh) * 2020-05-14 2023-06-27 维艾尔生物科技有限公司 Enpp1调节剂及其用途

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2021225969A1 (en) 2020-05-04 2021-11-11 Volastra Therapeutics, Inc. Imino sulfanone inhibitors of enpp1
TW202214640A (zh) 2020-06-16 2022-04-16 美商佛拉斯托醫療公司 Ｅｎｐｐ１之雜環抑制劑
WO2022091048A1 (en) 2020-10-30 2022-05-05 Integral Biosciences Private Limited Ectonucleotide pyrophosphatase-phosphodiesterase-1 (enpp1) inhibitors and uses thereof
WO2023086638A1 (en) * 2021-11-15 2023-05-19 Vir Biotechnology, Inc. Enpp1 modulators and uses thereof
JP2024545511A (ja) * 2021-12-09 2024-12-09 バラ セラピューティクス，インコーポレイテッド メニン－ｍｌｌ相互作用の阻害剤
WO2023168240A1 (en) * 2022-03-02 2023-09-07 The Regents Of The University Of California Small molecule inhibitors of enpp1
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