CN115925932A - 针对白细胞介素36受体（il-36r）的抗体 - Google Patents

针对白细胞介素36受体（il-36r）的抗体 Download PDF

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Publication number
CN115925932A
CN115925932A CN202210803364.8A CN202210803364A CN115925932A CN 115925932 A CN115925932 A CN 115925932A CN 202210803364 A CN202210803364 A CN 202210803364A CN 115925932 A CN115925932 A CN 115925932A
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Chinese (zh)
Inventor
P·鲍尔斯
A·J·麦克奈特
D·J·金
M·隆代伊
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Anaptysbio Inc
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Anaptysbio Inc
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2866—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against receptors for cytokines, lymphokines, interferons
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/06—Antipsoriatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/33—Crossreactivity, e.g. for species or epitope, or lack of said crossreactivity
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biochemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Rheumatology (AREA)
  • Microbiology (AREA)
  • Transplantation (AREA)
  • Pain & Pain Management (AREA)
  • Mycology (AREA)
  • Epidemiology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Dermatology (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
CN202210803364.8A 2015-04-15 2016-04-15 针对白细胞介素36受体（il-36r）的抗体 Pending CN115925932A (zh)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US201562147824P 2015-04-15 2015-04-15
US62/147,824 2015-04-15
CN201680034793.6A CN107847590B (zh) 2015-04-15 2016-04-15 针对白细胞介素36受体(il-36r)的抗体
PCT/US2016/027676 WO2016168542A1 (en) 2015-04-15 2016-04-15 Antibodies directed against interleukin 36 receptor (il-36r)

Related Parent Applications (1)

Application Number Title Priority Date Filing Date
CN201680034793.6A Division CN107847590B (zh) 2015-04-15 2016-04-15 针对白细胞介素36受体(il-36r)的抗体

Publications (1)

Publication Number Publication Date
CN115925932A true CN115925932A (zh) 2023-04-07

Family

ID=57126337

Family Applications (2)

Application Number Title Priority Date Filing Date
CN202210803364.8A Pending CN115925932A (zh) 2015-04-15 2016-04-15 针对白细胞介素36受体（il-36r）的抗体
CN201680034793.6A Active CN107847590B (zh) 2015-04-15 2016-04-15 针对白细胞介素36受体(il-36r)的抗体

Family Applications After (1)

Application Number Title Priority Date Filing Date
CN201680034793.6A Active CN107847590B (zh) 2015-04-15 2016-04-15 针对白细胞介素36受体(il-36r)的抗体

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Country Link
US (4) US10526410B2 (https=)
EP (2) EP3283110B1 (https=)
JP (4) JP6913026B2 (https=)
KR (1) KR102666920B1 (https=)
CN (2) CN115925932A (https=)
AU (1) AU2016248208B2 (https=)
CA (1) CA2982555A1 (https=)
DK (1) DK3283110T3 (https=)
ES (1) ES2914243T3 (https=)
MX (2) MX2017013080A (https=)
PL (1) PL3283110T3 (https=)
RU (1) RU2745898C2 (https=)
SG (1) SG11201708061TA (https=)
WO (1) WO2016168542A1 (https=)

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EP3400962A1 (en) * 2017-05-09 2018-11-14 Fraunhofer Gesellschaft zur Förderung der angewandten Forschung e.V. Inhibitors of il-38 for use in treating and/or preventing cancer in a subject
AU2018308088B2 (en) 2017-07-25 2025-05-29 Truebinding, Inc. Treating cancer by blocking the interaction of TIM-3 and its ligand
AU2019234478A1 (en) * 2018-03-14 2020-08-20 Boehringer Ingelheim International Gmbh Use of anti-IL36R antibodies for treatment of inflammatory bowel disease
CA3093692A1 (en) * 2018-03-14 2019-09-19 Boehringer Ingelheim International Gmbh Use of anti-il-36r antibodies for treatment of generalized pustular psoriasis
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MX2021000566A (es) * 2018-07-16 2021-06-23 Regeneron Pharma Anticuerpos anti-il36r.
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EP3902604A1 (en) * 2018-12-27 2021-11-03 Boehringer Ingelheim International GmbH Anti-il-36r antibodies for treatment of palmoplantar pustulosis
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JP7811772B2 (ja) * 2019-12-05 2026-02-06 学校法人東京薬科大学 筋組織の減少を抑制するための組成物
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EP4182022A1 (en) * 2020-07-17 2023-05-24 Boehringer Ingelheim International GmbH Anti-il-36r antibodies for the treatment of neutrophilic dermatoses
JP2023536851A (ja) * 2020-07-30 2023-08-30 アナプティスバイオ インコーポレイティッド 魚鱗癬のための抗インターロイキン３６受容体（ｉｌ－３６ｒ）療法
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CN112094349B (zh) * 2020-11-04 2021-02-09 上海华奥泰生物药业股份有限公司 靶向于白介素36r的抗体及其制备方法和应用
WO2022150642A1 (en) 2021-01-08 2022-07-14 Anaptysbio, Inc. Anti-interleukin 36 receptor (il-36r) therapy for hidradenitis suppurativa
WO2022150644A1 (en) 2021-01-08 2022-07-14 Anaptysbio, Inc. Anti-interleukin 36 receptor (il-36r) therapy for acne
CA3209006A1 (en) * 2021-03-04 2022-09-09 Boehringer Ingelheim International Gmbh Methods for the treatment of gpp
WO2022192531A2 (en) 2021-03-12 2022-09-15 Boehringer Ingelheim International Gmbh Biomarkers associated with anti-il-36r antibody treatment in generalized pustular psoriasis
CA3218343A1 (en) * 2021-05-12 2022-11-17 Anaptysbio, Inc. Antibody composition
EP4370550A1 (en) 2021-07-12 2024-05-22 INSERM (Institut National de la Santé et de la Recherche Médicale) Use of il-36 inhibitors for the treatment of netherton syndrome
TW202323293A (zh) * 2021-10-29 2023-06-16 新加坡商創響私人有限公司 新型抗ｉｌ－３６ｒ抗體
CN115724975A (zh) 2022-10-20 2023-03-03 江苏荃信生物医药股份有限公司 抗人白介素36受体单克隆抗体及其应用

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BR112017022086A2 (pt) 2018-07-03
SG11201708061TA (en) 2017-10-30
US12391761B2 (en) 2025-08-19
RU2017139481A (ru) 2019-05-15
JP7721585B2 (ja) 2025-08-12
HK1250941A1 (en) 2019-01-18
US10526410B2 (en) 2020-01-07
RU2017139481A3 (https=) 2019-09-19
US11130814B2 (en) 2021-09-28
CN107847590A (zh) 2018-03-27
JP7212098B2 (ja) 2023-01-24
US20200087408A1 (en) 2020-03-19
CA2982555A1 (en) 2016-10-20
WO2016168542A1 (en) 2016-10-20
ES2914243T3 (es) 2022-06-08
KR20180002687A (ko) 2018-01-08
AU2016248208B2 (en) 2022-03-24
RU2745898C2 (ru) 2021-04-02
KR102666920B1 (ko) 2024-05-20
US20180094065A1 (en) 2018-04-05
EP3283110A1 (en) 2018-02-21
JP2025163120A (ja) 2025-10-28
NZ736535A (en) 2024-08-30
US20210388095A1 (en) 2021-12-16
CN107847590B (zh) 2022-07-26
EP4176900A1 (en) 2023-05-10
DK3283110T3 (da) 2022-05-23
JP2023040236A (ja) 2023-03-22
HK1252009A1 (zh) 2019-05-10
EP3283110B1 (en) 2022-04-20
PL3283110T3 (pl) 2022-06-27
JP6913026B2 (ja) 2021-08-04
AU2016248208A1 (en) 2017-11-09
EP3283110A4 (en) 2019-02-27
MX2017013080A (es) 2018-02-09
JP2018512157A (ja) 2018-05-17
US20260022181A1 (en) 2026-01-22
JP2021118710A (ja) 2021-08-12
MX2023001791A (es) 2023-03-10

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