CN115872881A - 一种薄荷醇胺类化合物的合成方法及其在卷烟中的应用 - Google Patents
一种薄荷醇胺类化合物的合成方法及其在卷烟中的应用 Download PDFInfo
- Publication number
- CN115872881A CN115872881A CN202211418342.6A CN202211418342A CN115872881A CN 115872881 A CN115872881 A CN 115872881A CN 202211418342 A CN202211418342 A CN 202211418342A CN 115872881 A CN115872881 A CN 115872881A
- Authority
- CN
- China
- Prior art keywords
- menthol
- reaction
- amine
- amine compound
- additive
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- NOOLISFMXDJSKH-UHFFFAOYSA-N DL-menthol Natural products CC(C)C1CCC(C)CC1O NOOLISFMXDJSKH-UHFFFAOYSA-N 0.000 title claims abstract description 50
- -1 menthol amine compound Chemical class 0.000 title claims abstract description 46
- 229940041616 menthol Drugs 0.000 title claims abstract description 44
- 238000001308 synthesis method Methods 0.000 title claims abstract description 9
- 235000019504 cigarettes Nutrition 0.000 title claims description 15
- 238000006243 chemical reaction Methods 0.000 claims abstract description 34
- 239000000654 additive Substances 0.000 claims abstract description 16
- 230000000996 additive effect Effects 0.000 claims abstract description 16
- 150000001412 amines Chemical class 0.000 claims abstract description 16
- 239000007810 chemical reaction solvent Substances 0.000 claims abstract description 7
- 238000000034 method Methods 0.000 claims description 17
- WYURNTSHIVDZCO-UHFFFAOYSA-N Tetrahydrofuran Chemical group C1CCOC1 WYURNTSHIVDZCO-UHFFFAOYSA-N 0.000 claims description 16
- LSTRKXWIZZZYAS-UHFFFAOYSA-N 2-bromoacetyl bromide Chemical compound BrCC(Br)=O LSTRKXWIZZZYAS-UHFFFAOYSA-N 0.000 claims description 13
- 239000000779 smoke Substances 0.000 claims description 12
- 150000003839 salts Chemical class 0.000 claims description 8
- 230000002194 synthesizing effect Effects 0.000 claims description 8
- YMWUJEATGCHHMB-UHFFFAOYSA-N Dichloromethane Chemical group ClCCl YMWUJEATGCHHMB-UHFFFAOYSA-N 0.000 claims description 6
- AFBPFSWMIHJQDM-UHFFFAOYSA-N N-methylaniline Chemical compound CNC1=CC=CC=C1 AFBPFSWMIHJQDM-UHFFFAOYSA-N 0.000 claims description 6
- 239000003205 fragrance Substances 0.000 claims description 6
- DPBLXKKOBLCELK-UHFFFAOYSA-N pentan-1-amine Chemical compound CCCCCN DPBLXKKOBLCELK-UHFFFAOYSA-N 0.000 claims description 6
- WGYKZJWCGVVSQN-UHFFFAOYSA-N mono-n-propyl amine Natural products CCCN WGYKZJWCGVVSQN-UHFFFAOYSA-N 0.000 claims description 5
- 230000035484 reaction time Effects 0.000 claims description 4
- 239000002904 solvent Substances 0.000 claims description 4
- 229940100684 pentylamine Drugs 0.000 claims description 3
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims description 2
- YLQBMQCUIZJEEH-UHFFFAOYSA-N tetrahydrofuran Natural products C=1C=COC=1 YLQBMQCUIZJEEH-UHFFFAOYSA-N 0.000 claims description 2
- NOOLISFMXDJSKH-UTLUCORTSA-N (+)-Neomenthol Chemical compound CC(C)[C@@H]1CC[C@@H](C)C[C@@H]1O NOOLISFMXDJSKH-UTLUCORTSA-N 0.000 claims 2
- 125000006308 propyl amino group Chemical group 0.000 claims 1
- QUERMGFVJPRMJL-UHFFFAOYSA-N tert-butyl azetidine-1-carboxylate Chemical compound CC(C)(C)OC(=O)N1CCC1 QUERMGFVJPRMJL-UHFFFAOYSA-N 0.000 claims 1
- 239000003814 drug Substances 0.000 abstract description 3
- 230000000844 anti-bacterial effect Effects 0.000 abstract description 2
- 230000035515 penetration Effects 0.000 abstract description 2
- 230000001737 promoting effect Effects 0.000 abstract 2
- 230000003110 anti-inflammatory effect Effects 0.000 abstract 1
- 230000000840 anti-viral effect Effects 0.000 abstract 1
- 230000000975 bioactive effect Effects 0.000 abstract 1
- 230000007794 irritation Effects 0.000 abstract 1
- 231100000435 percutaneous penetration Toxicity 0.000 abstract 1
- 230000001988 toxicity Effects 0.000 abstract 1
- 231100000419 toxicity Toxicity 0.000 abstract 1
- 239000011734 sodium Substances 0.000 description 37
- XEKOWRVHYACXOJ-UHFFFAOYSA-N Ethyl acetate Chemical compound CCOC(C)=O XEKOWRVHYACXOJ-UHFFFAOYSA-N 0.000 description 30
- NOOLISFMXDJSKH-KXUCPTDWSA-N (-)-Menthol Chemical compound CC(C)[C@@H]1CC[C@@H](C)C[C@H]1O NOOLISFMXDJSKH-KXUCPTDWSA-N 0.000 description 19
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 16
- RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 description 14
- 241000208125 Nicotiana Species 0.000 description 14
- 235000002637 Nicotiana tabacum Nutrition 0.000 description 14
- 239000000047 product Substances 0.000 description 13
- 239000012043 crude product Substances 0.000 description 12
- 235000019439 ethyl acetate Nutrition 0.000 description 12
- 150000001875 compounds Chemical class 0.000 description 7
- 230000006837 decompression Effects 0.000 description 6
- 238000001914 filtration Methods 0.000 description 6
- 235000013305 food Nutrition 0.000 description 6
- 239000012044 organic layer Substances 0.000 description 6
- 239000003208 petroleum Substances 0.000 description 6
- 238000010992 reflux Methods 0.000 description 6
- 230000000391 smoking effect Effects 0.000 description 6
- 239000012230 colorless oil Substances 0.000 description 5
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 description 4
- HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 description 4
- 238000005580 one pot reaction Methods 0.000 description 4
- 239000000741 silica gel Substances 0.000 description 4
- 229910002027 silica gel Inorganic materials 0.000 description 4
- 238000003786 synthesis reaction Methods 0.000 description 4
- 230000004071 biological effect Effects 0.000 description 3
- 230000015572 biosynthetic process Effects 0.000 description 3
- 230000005484 gravity Effects 0.000 description 3
- 239000002994 raw material Substances 0.000 description 3
- 229910052723 transition metal Inorganic materials 0.000 description 3
- 150000003624 transition metals Chemical class 0.000 description 3
- 239000003513 alkali Substances 0.000 description 2
- 238000011156 evaluation Methods 0.000 description 2
- 229910001385 heavy metal Inorganic materials 0.000 description 2
- 229910052751 metal Inorganic materials 0.000 description 2
- 239000002184 metal Substances 0.000 description 2
- 239000003921 oil Substances 0.000 description 2
- 235000019198 oils Nutrition 0.000 description 2
- 238000010898 silica gel chromatography Methods 0.000 description 2
- 239000000758 substrate Substances 0.000 description 2
- 238000010189 synthetic method Methods 0.000 description 2
- 101100037762 Caenorhabditis elegans rnh-2 gene Proteins 0.000 description 1
- 206010016322 Feeling abnormal Diseases 0.000 description 1
- 241000282414 Homo sapiens Species 0.000 description 1
- 235000014435 Mentha Nutrition 0.000 description 1
- 241001072983 Mentha Species 0.000 description 1
- 229930013930 alkaloid Natural products 0.000 description 1
- 125000000217 alkyl group Chemical group 0.000 description 1
- 230000003444 anaesthetic effect Effects 0.000 description 1
- 239000003242 anti bacterial agent Substances 0.000 description 1
- 230000000843 anti-fungal effect Effects 0.000 description 1
- 229940088710 antibiotic agent Drugs 0.000 description 1
- 229940121375 antifungal agent Drugs 0.000 description 1
- KVVMXWRFYAGASO-UHFFFAOYSA-N azetidine-1-carboxylic acid Chemical compound OC(=O)N1CCC1 KVVMXWRFYAGASO-UHFFFAOYSA-N 0.000 description 1
- 239000002585 base Substances 0.000 description 1
- 239000010953 base metal Substances 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 230000002113 chemopreventative effect Effects 0.000 description 1
- 230000001055 chewing effect Effects 0.000 description 1
- 230000035597 cooling sensation Effects 0.000 description 1
- 239000002537 cosmetic Substances 0.000 description 1
- 125000004122 cyclic group Chemical group 0.000 description 1
- KZZKOVLJUKWSKX-UHFFFAOYSA-N cyclobutanamine Chemical compound NC1CCC1 KZZKOVLJUKWSKX-UHFFFAOYSA-N 0.000 description 1
- VXVVUHQULXCUPF-UHFFFAOYSA-N cycloheptanamine Chemical compound NC1CCCCCC1 VXVVUHQULXCUPF-UHFFFAOYSA-N 0.000 description 1
- 201000010099 disease Diseases 0.000 description 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 1
- 229940079593 drug Drugs 0.000 description 1
- 238000001035 drying Methods 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 230000002708 enhancing effect Effects 0.000 description 1
- 238000000605 extraction Methods 0.000 description 1
- 229940088597 hormone Drugs 0.000 description 1
- 239000005556 hormone Substances 0.000 description 1
- 230000002519 immonomodulatory effect Effects 0.000 description 1
- 238000009776 industrial production Methods 0.000 description 1
- 208000015181 infectious disease Diseases 0.000 description 1
- 239000001525 mentha piperita l. herb oil Substances 0.000 description 1
- 229930003658 monoterpene Natural products 0.000 description 1
- 150000002773 monoterpene derivatives Chemical class 0.000 description 1
- 235000002577 monoterpenes Nutrition 0.000 description 1
- 229930014626 natural product Natural products 0.000 description 1
- 102000039446 nucleic acids Human genes 0.000 description 1
- 108020004707 nucleic acids Proteins 0.000 description 1
- 150000007523 nucleic acids Chemical class 0.000 description 1
- 235000019477 peppermint oil Nutrition 0.000 description 1
- 230000001766 physiological effect Effects 0.000 description 1
- 239000010970 precious metal Substances 0.000 description 1
- 108090000623 proteins and genes Proteins 0.000 description 1
- 102000004169 proteins and genes Human genes 0.000 description 1
- 239000000376 reactant Substances 0.000 description 1
- 238000000926 separation method Methods 0.000 description 1
- 238000003892 spreading Methods 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 125000001424 substituent group Chemical group 0.000 description 1
- QHFHVAFTZAZYJG-UHFFFAOYSA-N tert-butyl 1,3-diaminocyclobutane-1-carboxylate Chemical compound C(C)(C)(C)OC(=O)C1(CC(C1)N)N QHFHVAFTZAZYJG-UHFFFAOYSA-N 0.000 description 1
- 125000000999 tert-butyl group Chemical group [H]C([H])([H])C(*)(C([H])([H])[H])C([H])([H])[H] 0.000 description 1
- 239000000341 volatile oil Substances 0.000 description 1
Images
Classifications
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
Landscapes
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Fats And Perfumes (AREA)
Abstract
Description
技术领域
本发明属于有机合成技术领域,具体涉及一种方法简易,反应条件温和的薄荷醇胺类化合物的一锅法制备方法。
背景技术
薄荷醇(又称L-薄荷醇)是一种具有显著生物学特性的简单的环状单萜醇,薄荷醇是薄荷属植物油中重要的精油成分,L-薄荷醇和富含薄荷醇的薄荷油具有多种生物学特性,包括抗菌、抗真菌、麻醉和渗透增强作用,以及化学预防和免疫调节作用。薄荷醇的主要效果之一是咀嚼、吸入或涂抹在皮肤上时产生的凉爽感。在传统医学中用于治疗包括感染在内的各种疾病,目前,薄荷醇已被广泛应用于从制药和化妆品工业到烟草和食品工业的各个领域。
胺类物质广泛存在于生物界,具有极重要的生理活性和生物活性,如蛋白质、核酸、许多激素、抗生素和生物碱等都是胺的衍生物,临床上使用的大多数药物也是胺或者胺的衍生物,而掌握胺的性质和合成方法是研究这些复杂天然产物及更好地维护人类健康的前提。
因此,开发一种薄荷醇胺类化合物的合成方法具有重要的实用价值。目前有关构建该类化合物的合成方法较少。例如可以在强碱(如KOH,NaOH等)的碱性环境中,薄荷醇与胺类化合物发生反应,通常先由薄荷醇在强碱性条件下,在适当的溶剂中(常用醇或醚作溶剂)形成对应的盐,然后再进行后处理,最后与胺类衍生物应形成薄荷醇胺类化合物;亦或者在重金属盐或过度金属的作用下合成制备薄荷醇胺类化合物。综上所述,现在合成薄荷醇胺类化合物需要强碱或贵重金属盐催化,而这些重金属盐及强碱对生态环境会产生污染,后处理较为繁琐,底物范围有限,且合成策略原子经济性往往不高。这些缺点不符合绿色合成的理念且很难适应工业化生产的要求。
为了解决以上问题,提出本发明。
发明内容
本发明的目的在于提供一种在温和条件下,一种由薄荷醇、溴乙酰溴和胺类衍生物参与的多组分一锅法制备薄荷醇胺类化合物的方法。该方法条件温和,无过渡金属,利用廉价原料高效制备薄荷醇胺类化合物。为实现上述目的,本发明采用的技术方案为:
以薄荷醇、溴乙酰溴和胺类衍生物为反应原料,在无机金属盐Na2CO3、Na2SO4参与条件下,多组分一锅法得到薄荷醇胺衍生物。
具体的合成方法为:在空气环境下,将薄荷醇和溴乙酰溴放入反应容器中,加入第一添加剂,在第一溶剂下进行第一步反应,然后加入胺类衍生物和第二添加剂,在第二反应溶剂下进行反应,制备得到薄荷醇胺类化合物,其反应式为:
优选地,第一步反应进行4小时后,继续添加第二步反应物,升温反应6小时后,进行后处理。
优选地,所述薄荷醇胺类化合物包括2-异丙基-5-甲基环己基丙基甘氨酸、2-异丙基-5-甲基环己基戊基甘氨酸、2-异丙基-5-甲基环己基环丁基甘氨酸、2-异丙基-5-甲基环己基环庚基甘氨酸、2-异丙基-5-甲基环己基N-甲基-N-苯基甘氨酸或者3-((2-((2-异丙基-5-甲基环己基)氧基)-2-氧乙基)氨基)氮杂环丁烷-1-羧酸叔丁酯。
优选地,所述胺类衍生物为丙胺、戊胺和N-甲基苯胺各类胺类化合物。
优选地,所述所述第一添加剂和所述第二添加剂为无机盐,其中所述第一添加剂为Na2CO3,所述第二添加剂为Na2CO3和Na2SO4。
优选地,所述第一反应溶剂为二氯甲烷,第二反应溶剂为四氢呋喃。
优选地,所述薄荷醇、溴乙酰溴、胺类衍生物的摩尔比为1:0.5:5~1:2:5。
优选地,所述第一步反应温度为10-50℃,反应时间2~5小时,第二步反应温度为50-100℃,反应时间4~10小时。
本发明第二方面提供一种本发明第一方面所述的合成方法制备的薄荷醇胺类化合物的在卷烟中的应用,将其作为添加剂添加于卷烟中,以丰富香气量,增加润感,改善烟气柔和度。具体的,将产物溶于食品级乙醇,按照烟丝比重的一定比例添加到烟丝中,制成卷烟。
相对于现有技术,本发明具有以下有益效果:
1、本发明提供了一种绿色、经济实用的薄荷醇胺类化合物合成方法。该方法在无机金属盐Na2CO3、Na2SO4参与的条件下,薄荷醇、溴乙酰溴和胺类衍生物为原料多组分一锅法制备。该方法条件温和,无过渡金属,利用廉价原料高效制备薄荷醇胺类化合物。本发明方法绿色、新颖,具有良好的底物适应性。
2、将本发明合成的薄荷醇胺类化合物作为添加剂添加于卷烟中,可以丰富香气量,增加润感,改善烟气柔和度。
附图说明
图1为本发明的反应通式其中胺类化合物的通式为RNH2,R为烷基等取代基。
具体实施方式
下列实施例将有助于理解本发明,但本发明的内容并不局限于此。以下实施例中的反应通式为:
实施例1:
将DL-薄荷醇(1.0eq)溶解于5mLDCM中,再添加Na2CO3,待溶液冷却至0℃,缓慢滴加溴乙酰溴(1.0eq),移除冷浴反应器,室温下反应4h,真空减压浓缩得粗产物。将粗产物溶于5mlTHF中,添加丙胺(1.5eq),然后添加无水Na2CO3(2.5eq)和无水Na2SO4,70℃回流6h,反应结束后,将溶液进行过滤去除无水Na2SO4,用EtOAc(3×10ml)萃取三次后,无水Na2SO4干燥有机层,减压浓缩,用硅胶色谱柱分离(石油醚/乙酸乙酯)得到无色油状目标产物。
1HNMR(400MHz,CDCl3):δ4.71(td,J=10.92Hz,4.00Hz,1H),3.45(S,2H),1.96-1.93(m,1H),1.82-1.78(m,1H),1.66-1.61(m,2H),1.49-1.31(m,3H),1.03-0.94(m,2H),0.86(t,J=6.12Hz,7H),0.72(d,J=6.96Hz,3H);
13CNMR(100MHz,CDCl3):δ170.32,74.37,57.18,46.86,40.90,34.14,31.34,26.23,23.29,21.98,20.73,16.20,16.20.
MS:m/z,found:255.2198.
将得到的产物溶于食品级乙醇,按照烟丝比重的0.0001%-1%的比例添加到烟丝中,制成加热卷烟,经过评吸发现,与对照比较,该化合物可以丰富香气量,增加润感,改善烟气柔和度。
实施例2:
将DL-薄荷醇(1.0eq)溶解于5mLDCM中,再添加Na2CO3,待溶液冷却至0℃,缓慢滴加溴乙酰溴(1.0eq),移除冷浴反应器,室温下反应4h,真空减压浓缩得粗产物。将粗产物溶于5mlTHF中,添加戊胺(1.5eq),然后添加无水Na2CO3(2.5eq)和无水Na2SO4,70℃回流6h,反应结束后,将溶液进行过滤去除无水Na2SO4,用EtOAc(3×10ml)萃取三次后,无水Na2SO4干燥有机层,减压浓缩,用硅胶色谱柱分离(石油醚/乙酸乙酯)得到无色油状目标产物。
1HNMR(400MHz,CDCl3):δ4.74(td,J=10.88Hz,4.32Hz,1H),3.56(S,2H),2.73-2.68(m,1H),2.02-1.97(m,1H),1.87-1.83(m,1H),1.71-0.98(m,11H),0.94-0.89(m,11H),0.77(d,J=6.96Hz,3H);
13CNMR(100MHz,CDCl3):δ170.83,74.41,55.21,53.96,46.94,40.95,34.19,31.38,26.27,23.33,22.02,20.77,20.40,16.25,13.99.
MS:m/z,found:283.2511.
将得到的产物溶于食品级乙醇,按照烟丝比重的0.0001%-2%的比例添加到烟丝中,制成传统卷烟,经过评吸发现,与对照比较,该化合物可以增加香气,改善抽吸品质,略有清凉的味道。
实施例3:
将DL-薄荷醇(1.0eq)溶解于5mLDCM中,再添加Na2CO3,待溶液冷却至0℃,缓慢滴加溴乙酰溴(1.0eq),移除冷浴反应器,室温下反应4h,真空减压浓缩得粗产物。将粗产物溶于5mlTHF中,添加环丁胺(1.5eq),然后添加无水Na2CO3(2.5eq)和无水Na2SO4,70℃回流6h,反应结束后,将溶液进行过滤去除无水Na2SO4,用EtOAc(3×10ml)萃取三次后,无水Na2SO4干燥有机层,减压浓缩,用硅胶色谱柱分离(石油醚/乙酸乙酯)得到无色油状目标产物。
1HNMR(400MHz,CDCl3):δ4.73(td,J=10.88Hz,4.36Hz,1H),3.53(S,3H),2.06-1.80(m,5H),1.71-1.57(m,4H),1.51-1.26(m,4H),1.07-0.96(m,2H),0.90(t,J=6.4Hz,7H),0.76(d,J=6.96Hz,3H);
13CNMR(101MHz,CDCl3):δ170.84,74.29,57.00,51.02,46.94,34.19,31.37,30.30,27.88,26.27,23.36,22.02,20.76,20.76,16.27;
MS:m/z,found:267.2198.
将得到的产物溶于食品级乙醇,按照烟丝比重的0.0001%-2%的比例添加到烟丝中,制成传统卷烟,经过评吸发现,与对照比较,该化合物可以增加润感,改善抽吸品质。
实施例4:
将DL-薄荷醇(1.0eq)溶解于5mLDCM中,再添加Na2CO3,待溶液冷却至0℃,缓慢滴加溴乙酰溴(1.0eq),移除冷浴反应器,室温下反应4h,真空减压浓缩得粗产物。将粗产物溶于5mlTHF中,添加环庚胺(1.5eq),然后添加无水Na2CO3(2.5eq)和无水Na2SO4,70℃回流6h,反应结束后,将溶液进行过滤去除无水Na2SO4,用EtOAc(3×10ml)萃取三次后,无水Na2SO4干燥有机层,减压浓缩,用硅胶色谱柱分离(石油醚/乙酸乙酯)得到无色油状目标产物。
1HNMR(400MHz,CDCl3):δ4.73(td,J=10.88Hz,4.36Hz,1H),3.50(S,2H),2.06-1.98(m,2H),1.91-1.85(m,2H),1.70-1.66(m,4H),1.54-1.35(m,7H),1.29-1.25(m,1H),1.11-0.96(m,3H),0.92-0.76(m,13H);
13CNMR(101MHz,CDCl3):δ171.84,74.22,63.35,60.40,52.73,46.99,40.87,34.23,31.66,31.38,27.74,26.23,25.14,23.35,22.03,20.80,16.27,14.20.
MS:m/z,found:309.2668.
将得到的产物溶于食品级乙醇,按照烟丝比重的0.001%-1%的比例添加到卷烟纸中,制成传统卷烟,经过评吸发现,与对照比较,该化合物可以增加烟气香气量,改善烟气润感和柔和感。
实施例5:
将DL-薄荷醇(1.0eq)溶解于5mLDCM中,再添加Na2CO3,待溶液冷却至0℃,缓慢滴加溴乙酰溴(1.0eq),移除冷浴反应器,室温下反应4h,真空减压浓缩得粗产物。将粗产物溶于5mlTHF中,添加N-甲基苯胺(1.5eq),然后添加无水Na2CO3(2.5eq)和无水Na2SO4,70℃回流6h,反应结束后,将溶液进行过滤去除无水Na2SO4,用EtOAc(3×10ml)萃取三次后,无水Na2SO4干燥有机层,减压浓缩,用硅胶色谱柱分离(石油醚/乙酸乙酯)得到淡褐色油状目标产物。
1HNMR(400MHz,CDCl3):δ7.28-7.23(m,2H),6.76(t,J=7.28Hz,1H),6.70(d,J=8.2Hz,2H),4.70(td,J=10.88Hz,4.40Hz,1H),4.07(q,J=30.72Hz,18.04Hz,2H),3.09(S,3H),2.01-1.96(m,1H),1.69-1.63(m,3H),1.51-1.42(m,1H),1.35-1.28(m,1H),1.05-0.99(m,1H),0.91(d,J=6.52Hz,4H),0.83(d,J=7.04Hz,4H),0.68(d,J=6.96Hz,3H).
13CNMR(101MHz,CDCl3):δ170.89,148.91,129.14,129.14,117.25,112.28,112.28,74.97,54.91,46.93,40.81,39.77,34.15,31.36,25.96,23.15,22.01,20.81,16.02.
MS:m/z,found:303.2198.
将得到的产物溶于食品级乙醇,按照烟丝比重的0.0005%-3%的比例添加到烟丝中,制成传统卷烟,经过评吸发现,与对照比较,该化合物可以增加烟气香气量,增加烟气润感,改善舒适度。
实施例6:
将DL-薄荷醇(1.0eq)溶解于5mLDCM中,再添加Na2CO3,待溶液冷却至0℃,缓慢滴加溴乙酰溴(1.0eq),移除冷浴反应器,室温下反应4h,真空减压浓缩得粗产物。将粗产物溶于5mlTHF中,添加1-叔丁氧羰基-3-胺基环丁胺(1.5eq),然后添加无水Na2CO3(2.5eq)和无水Na2SO4,70℃回流6h,反应结束后,将溶液进行过滤去除无水Na2SO4,用EtOAc(3×10ml)萃取三次后,无水Na2SO4干燥有机层,减压浓缩,用硅胶色谱柱分离(石油醚/乙酸乙酯)得到无色油状目标产物。
1HNMR(400MHz,CDCl3):δ4.74(td,J=9.64Hz,3.16Hz,1H),4.74(td,J=9.64Hz,3.16Hz,1H),3.98-3.86(m,2H),3.62-3.56(m,2H),2.28-1.59(m,7H),1.51-1.26(m,11H),1.08-0.89(m,3H),0.81(t,J=6.24Hz,7H),0.76(d,J=6.96Hz,3H).
13CNMR(101MHz,CDCl3):δ170.48,156.26,125.53,79.50,74.81,46.92,46.92,40.89,34.14,31.39,30.31,28.38,28.38,28.38,26.37,23.36,22.02,20.76,20.76,16.29.
MS:m/z,found:368.2675.
将得到的产物溶于食品级乙醇,按照烟丝比重的0.0002%-2%的比例添加到烟丝中,制成传统卷烟,经过评吸发现,与对照比较,该化合物可以增加烟气香气量,增加润感,烟气更舒适。
Claims (9)
2.根据权利要求1所述的薄荷醇胺类化合物的合成方法,其特征在于,第一步反应进行4小时后,继续添加第二步反应物,升温反应6小时后,进行后处理。
3.根据权利要求1所述的薄荷醇胺类化合物的合成方法,其特征在于,所述薄荷醇胺类化合物包括2-异丙基-5-甲基环己基丙基甘氨酸、2-异丙基-5-甲基环己基戊基甘氨酸、2-异丙基-5-甲基环己基环丁基甘氨酸、2-异丙基-5-甲基环己基环庚基甘氨酸、2-异丙基-5-甲基环己基N-甲基-N-苯基甘氨酸或者3-((2-((2-异丙基-5-甲基环己基)氧基)-2-氧乙基)氨基)氮杂环丁烷-1-羧酸叔丁酯。
4.根据权利要求1所述的薄荷醇胺类化合物的合成方法,其特征在于,所述胺类衍生物为丙胺、戊胺和N-甲基苯胺。
5.根据权利要求1所述的薄荷醇胺类化合物的合成方法,其特征在于,所述所述第一添加剂和所述第二添加剂为无机盐,其中所述第一添加剂为Na2CO3,所述第二添加剂为Na2CO3和Na2SO4。
6.根据权利要求1所述的薄荷醇胺类化合物的合成方法,其特征在于,所述第一反应溶剂为二氯甲烷,第二反应溶剂为四氢呋喃。
7.根据权利要求1所述的薄荷醇胺类化合物的合成方法,其特征在于,所述薄荷醇、溴乙酰溴、胺类衍生物的摩尔比为1:0.5:5~1:2:5。
8.根据权利要求1所述的薄荷醇胺类化合物的合成方法,其特征在于,所述第一步反应温度为10~50℃,反应时间2~5小时,第二步反应温度为50~100℃,反应时间4~10小时。
9.一种权利要求1-8任一项所述的合成方法制备的薄荷醇胺类化合物的在卷烟中的应用,其特征在于,将其作为添加剂添加于卷烟中,以丰富香气量,增加润感,改善烟气柔和度。
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN202211418342.6A CN115872881A (zh) | 2022-11-14 | 2022-11-14 | 一种薄荷醇胺类化合物的合成方法及其在卷烟中的应用 |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN202211418342.6A CN115872881A (zh) | 2022-11-14 | 2022-11-14 | 一种薄荷醇胺类化合物的合成方法及其在卷烟中的应用 |
Publications (1)
Publication Number | Publication Date |
---|---|
CN115872881A true CN115872881A (zh) | 2023-03-31 |
Family
ID=85759826
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CN202211418342.6A Pending CN115872881A (zh) | 2022-11-14 | 2022-11-14 | 一种薄荷醇胺类化合物的合成方法及其在卷烟中的应用 |
Country Status (1)
Country | Link |
---|---|
CN (1) | CN115872881A (zh) |
Citations (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3991178A (en) * | 1973-07-13 | 1976-11-09 | Lever Brothers Company | Menthyl ester of N-acetylglycine and oral compositions containing same |
EP0310299A1 (en) * | 1987-09-28 | 1989-04-05 | The Procter & Gamble Company | Beta-amino acid ester derivatives of alcoholic actives having extended duration of activity |
JP2005041783A (ja) * | 2003-07-22 | 2005-02-17 | Osaka Organic Chem Ind Ltd | 清涼剤 |
CN1915966A (zh) * | 2006-06-01 | 2007-02-21 | 汕头大学 | 新型薄荷醇衍生物及其制备方法和应用 |
CN101184470A (zh) * | 2005-05-27 | 2008-05-21 | 吉万奥丹股份有限公司 | 清凉化合物 |
US20100226864A1 (en) * | 2009-03-06 | 2010-09-09 | Symrise Gmbh & Co. Kg | Alkyl-substituted tetrahydropyrans as flavoring substances |
CN114555560A (zh) * | 2019-09-30 | 2022-05-27 | 北伊利诺伊大学董事会 | 薄荷醇的衍生物及其用途 |
-
2022
- 2022-11-14 CN CN202211418342.6A patent/CN115872881A/zh active Pending
Patent Citations (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3991178A (en) * | 1973-07-13 | 1976-11-09 | Lever Brothers Company | Menthyl ester of N-acetylglycine and oral compositions containing same |
EP0310299A1 (en) * | 1987-09-28 | 1989-04-05 | The Procter & Gamble Company | Beta-amino acid ester derivatives of alcoholic actives having extended duration of activity |
JP2005041783A (ja) * | 2003-07-22 | 2005-02-17 | Osaka Organic Chem Ind Ltd | 清涼剤 |
CN101184470A (zh) * | 2005-05-27 | 2008-05-21 | 吉万奥丹股份有限公司 | 清凉化合物 |
CN1915966A (zh) * | 2006-06-01 | 2007-02-21 | 汕头大学 | 新型薄荷醇衍生物及其制备方法和应用 |
US20100226864A1 (en) * | 2009-03-06 | 2010-09-09 | Symrise Gmbh & Co. Kg | Alkyl-substituted tetrahydropyrans as flavoring substances |
CN114555560A (zh) * | 2019-09-30 | 2022-05-27 | 北伊利诺伊大学董事会 | 薄荷醇的衍生物及其用途 |
Non-Patent Citations (3)
Title |
---|
FRANKLAND, P. F.等: "Influence of Double Linking on Optical Activity; some n-Propyl and Ally Derivatives atives of Menthol", JOURNAL OF THE CHEMICAL SOCIETY, TRANSACTIONS, vol. 99, 1 January 1911 (1911-01-01), pages 2325 - 2336 * |
FRANKLAND, PERCY F.等: "Menthyl esters of chloroacetic, menthoxyacetic and methylanilinoacetic acids", JOURNAL OF THE CHEMICAL SOCIETY, TRANSACTIONS, vol. 105, 1 January 1914 (1914-01-01), pages 990 - 994 * |
彭安顺: "有机化学", 30 September 2012, pages: 102 * |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
CN108285441A (zh) | 一种尼古丁-扁桃酸盐复合物晶体、其制备方法及包含其的烟草制品 | |
NO152899B (no) | Analogifremgangsmaate for fremstilling av terapeutisk aktive glycerolderivater | |
CN110862366B (zh) | 一种奶香型烟草甜味剂、制备方法及在卷烟中的应用 | |
DE2500772A1 (de) | Neue verbindungen, verfahren zu deren herstellung und deren verwendung | |
US3857972A (en) | Flavoring with an oxocyclic pyrimidine | |
DE2332837A1 (de) | Amine, verfahren zu ihrer herstellung und sie enthaltende arzneimittel | |
CN115872881A (zh) | 一种薄荷醇胺类化合物的合成方法及其在卷烟中的应用 | |
US4312874A (en) | Antibacterial compounds, processes for their preparation and compositions containing them | |
EP0470766A2 (en) | Smoking composition containing a vanillin-release additive | |
CN113277947B (zh) | 烟用单体香料3-(2-羟基苯基)丙酸-2羟基丙酯及其合成方法与应用 | |
CN114516797B (zh) | 一种甲基环戊烯醇酮薄荷醇碳酸酯香料及其合成方法与应用 | |
CN110862365B (zh) | 一种烟用甜味剂、制备方法及应用 | |
CN114392262A (zh) | 抑制神经系统退行性疾病的白桦脂酸衍生物 | |
CN110981862B (zh) | 一种化合物及其合成方法、应用、烟草制品 | |
JP2022536035A (ja) | (z)型ソラノン、その製造方法および使用 | |
EP0045150A1 (en) | Antibacterial compounds, processes for their preparation and composititions containing them | |
CN114380693B (zh) | 一种甲基环戊烯醇酮香叶醇碳酸酯香料及其合成方法与应用 | |
Hagiwara et al. | A stereoselective synthesis of (±)-malyngolide | |
JP3187909B2 (ja) | たばこ用香喫味改良剤 | |
DE2625110A1 (de) | Cyclopropanolderivate, verfahren zu ihrer herstellung und sie enthaltende arzneimittel | |
CN106496147B (zh) | 烟用潜香单体5-甲基吡嗪-2-甲酸酯类的制备方法及其应用 | |
DE2848687A1 (de) | Monsaeure und deren derivate, verfahren zu ihrer herstellung und diese verbindungen enthaltende arzneipraeparate | |
EP0055616A1 (en) | Antibacterial compounds | |
CN117924377A (zh) | 一种1,4-脱水-d-吡喃葡萄糖的制备方法及应用 | |
JP3368072B2 (ja) | たばこ香喫味改善剤 |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
PB01 | Publication | ||
PB01 | Publication | ||
SE01 | Entry into force of request for substantive examination | ||
SE01 | Entry into force of request for substantive examination |