CN115867273A - 吡啶并吡唑类化合物的晶型及其制备方法 - Google Patents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- C07C57/02—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms with only carbon-to-carbon double bonds as unsaturation
- C07C57/13—Dicarboxylic acids
- C07C57/15—Fumaric acid
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- C07C59/235—Saturated compounds containing more than one carboxyl group
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- C07C59/235—Saturated compounds containing more than one carboxyl group
- C07C59/245—Saturated compounds containing more than one carboxyl group containing hydroxy or O-metal groups
- C07C59/285—Polyhydroxy dicarboxylic acids having five or more carbon atoms, e.g. saccharic acids
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
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Abstract
提供式(II)～式(VIII)化合物、式(I)～式(VIII‑1)化合物的晶型及其制备方法，以及所述晶型在制备治疗相关疾病的药物中的应用。
Description
PCT国内申请，说明书已公开。
Claims (13)
- PCT国内申请，权利要求书已公开。
Applications Claiming Priority (7)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2020110512529 | 2020-09-29 | ||
| CN202011051252 | 2020-09-29 | ||
| CN202011118921 | 2020-10-19 | ||
| CN202011118921X | 2020-10-19 | ||
| CN202110051653 | 2021-01-13 | ||
| CN2021100516532 | 2021-01-13 | ||
| PCT/CN2021/120750 WO2022068739A1 (zh) | 2020-09-29 | 2021-09-26 | 吡啶并吡唑类化合物的晶型及其制备方法 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN115867273A true CN115867273A (zh) | 2023-03-28 |
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN202180049587.3A Pending CN115867273A (zh) | 2020-09-29 | 2021-09-26 | 吡啶并吡唑类化合物的晶型及其制备方法 |
Country Status (5)
| Country | Link |
|---|---|
| US (1) | US20230365596A1 (zh) |
| EP (1) | EP4194455A4 (zh) |
| JP (1) | JP2023539331A (zh) |
| CN (1) | CN115867273A (zh) |
| WO (1) | WO2022068739A1 (zh) |
Citations (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2018049127A1 (en) * | 2016-09-08 | 2018-03-15 | Sabila Biosciences Llc | 1,2-dithiolane compounds useful in neuroprotection, autoimmune and cancer diseases and conditions |
| CN108349969A (zh) * | 2015-07-16 | 2018-07-31 | 阵列生物制药公司 | 作为RET激酶抑制剂的取代的吡唑并[1,5-a]吡啶化合物 |
| CN109563097A (zh) * | 2016-11-23 | 2019-04-02 | 无锡福祈制药有限公司 | 一种7H-吡咯并[2,3-d]嘧啶类化合物的晶型、盐型及其制备方法 |
| CN110506043A (zh) * | 2017-04-13 | 2019-11-26 | 癌症研究科技有限公司 | 适用作ret抑制剂的化合物 |
| CN111527073A (zh) * | 2017-12-15 | 2020-08-11 | 南京明德新药研发有限公司 | 一种4-(萘-1-基)-4h-1,2,4-三唑类类化合物的晶型、盐型及其制备方法 |
| CN111683949A (zh) * | 2018-01-29 | 2020-09-18 | 石家庄智康弘仁新药开发有限公司 | 一种1H-咪唑并[4,5-b]吡啶-2(3H)-酮类化合物的晶型及其制备方法 |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20210379056A1 (en) * | 2018-09-30 | 2021-12-09 | Applied Pharmaceutical Science, Inc. | Substituted pyrazole fused ring derivative, preparation method therefor, and application thereof |
| WO2020094084A1 (zh) * | 2018-11-07 | 2020-05-14 | 南京明德新药研发有限公司 | 作为ret抑制剂的三并环衍生物 |
| WO2020114388A1 (zh) * | 2018-12-06 | 2020-06-11 | 深圳市塔吉瑞生物医药有限公司 | 取代的吡唑并[1,5-a]吡啶化合物及包含该化合物的组合物及其用途 |
| BR112021019643A2 (pt) * | 2019-04-03 | 2021-12-07 | Guangzhou Baiyunshan Pharmaceutical Holdings Co Ltd Baiyunshan Pharmaceutical General Factory | Compostos de pirazolopiridina como inibidores do ret e uso dos mesmos |
-
2021
- 2021-09-26 WO PCT/CN2021/120750 patent/WO2022068739A1/zh unknown
- 2021-09-26 EP EP21874399.5A patent/EP4194455A4/en active Pending
- 2021-09-26 US US18/246,893 patent/US20230365596A1/en active Pending
- 2021-09-26 CN CN202180049587.3A patent/CN115867273A/zh active Pending
- 2021-09-26 JP JP2023514032A patent/JP2023539331A/ja active Pending
Patent Citations (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108349969A (zh) * | 2015-07-16 | 2018-07-31 | 阵列生物制药公司 | 作为RET激酶抑制剂的取代的吡唑并[1,5-a]吡啶化合物 |
| WO2018049127A1 (en) * | 2016-09-08 | 2018-03-15 | Sabila Biosciences Llc | 1,2-dithiolane compounds useful in neuroprotection, autoimmune and cancer diseases and conditions |
| CN109563097A (zh) * | 2016-11-23 | 2019-04-02 | 无锡福祈制药有限公司 | 一种7H-吡咯并[2,3-d]嘧啶类化合物的晶型、盐型及其制备方法 |
| CN110506043A (zh) * | 2017-04-13 | 2019-11-26 | 癌症研究科技有限公司 | 适用作ret抑制剂的化合物 |
| CN111527073A (zh) * | 2017-12-15 | 2020-08-11 | 南京明德新药研发有限公司 | 一种4-(萘-1-基)-4h-1,2,4-三唑类类化合物的晶型、盐型及其制备方法 |
| CN111683949A (zh) * | 2018-01-29 | 2020-09-18 | 石家庄智康弘仁新药开发有限公司 | 一种1H-咪唑并[4,5-b]吡啶-2(3H)-酮类化合物的晶型及其制备方法 |
Also Published As
| Publication number | Publication date |
|---|---|
| EP4194455A1 (en) | 2023-06-14 |
| JP2023539331A (ja) | 2023-09-13 |
| WO2022068739A1 (zh) | 2022-04-07 |
| US20230365596A1 (en) | 2023-11-16 |
| EP4194455A4 (en) | 2024-04-03 |
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