CN115813780A - Nano-scale yellow-dispelling composition containing tetrahydrocurcumin and preparation method thereof - Google Patents
Nano-scale yellow-dispelling composition containing tetrahydrocurcumin and preparation method thereof Download PDFInfo
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- CN115813780A CN115813780A CN202210327891.6A CN202210327891A CN115813780A CN 115813780 A CN115813780 A CN 115813780A CN 202210327891 A CN202210327891 A CN 202210327891A CN 115813780 A CN115813780 A CN 115813780A
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- LBTVHXHERHESKG-UHFFFAOYSA-N tetrahydrocurcumin Chemical compound C1=C(O)C(OC)=CC(CCC(=O)CC(=O)CCC=2C=C(OC)C(O)=CC=2)=C1 LBTVHXHERHESKG-UHFFFAOYSA-N 0.000 title claims abstract description 107
- 239000000203 mixture Substances 0.000 title claims abstract description 43
- 238000002360 preparation method Methods 0.000 title claims abstract description 11
- 239000003974 emollient agent Substances 0.000 claims abstract description 22
- 239000002904 solvent Substances 0.000 claims abstract description 22
- 239000003795 chemical substances by application Substances 0.000 claims abstract description 21
- 239000003906 humectant Substances 0.000 claims abstract description 18
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 15
- 238000002156 mixing Methods 0.000 claims abstract description 6
- 239000002994 raw material Substances 0.000 claims abstract description 6
- 239000011259 mixed solution Substances 0.000 claims description 38
- LEACJMVNYZDSKR-UHFFFAOYSA-N 2-octyldodecan-1-ol Chemical compound CCCCCCCCCCC(CO)CCCCCCCC LEACJMVNYZDSKR-UHFFFAOYSA-N 0.000 claims description 20
- UIVPNOBLHXUKDX-UHFFFAOYSA-N 3,5,5-trimethylhexyl 3,5,5-trimethylhexanoate Chemical compound CC(C)(C)CC(C)CCOC(=O)CC(C)CC(C)(C)C UIVPNOBLHXUKDX-UHFFFAOYSA-N 0.000 claims description 20
- YPFDHNVEDLHUCE-UHFFFAOYSA-N 1,3-propanediol Substances OCCCO YPFDHNVEDLHUCE-UHFFFAOYSA-N 0.000 claims description 19
- 150000001875 compounds Chemical class 0.000 claims description 19
- IIZPXYDJLKNOIY-JXPKJXOSSA-N 1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphocholine Chemical compound CCCCCCCCCCCCCCCC(=O)OC[C@H](COP([O-])(=O)OCC[N+](C)(C)C)OC(=O)CCC\C=C/C\C=C/C\C=C/C\C=C/CCCCC IIZPXYDJLKNOIY-JXPKJXOSSA-N 0.000 claims description 17
- HBTAOSGHCXUEKI-UHFFFAOYSA-N 4-chloro-n,n-dimethyl-3-nitrobenzenesulfonamide Chemical compound CN(C)S(=O)(=O)C1=CC=C(Cl)C([N+]([O-])=O)=C1 HBTAOSGHCXUEKI-UHFFFAOYSA-N 0.000 claims description 17
- BTFJIXJJCSYFAL-UHFFFAOYSA-N arachidyl alcohol Natural products CCCCCCCCCCCCCCCCCCCCO BTFJIXJJCSYFAL-UHFFFAOYSA-N 0.000 claims description 17
- 239000004359 castor oil Substances 0.000 claims description 17
- 235000019438 castor oil Nutrition 0.000 claims description 17
- 229940031578 diisopropyl adipate Drugs 0.000 claims description 17
- POULHZVOKOAJMA-UHFFFAOYSA-M dodecanoate Chemical compound CCCCCCCCCCCC([O-])=O POULHZVOKOAJMA-UHFFFAOYSA-M 0.000 claims description 17
- ZEMPKEQAKRGZGQ-XOQCFJPHSA-N glycerol triricinoleate Natural products CCCCCC[C@@H](O)CC=CCCCCCCCC(=O)OC[C@@H](COC(=O)CCCCCCCC=CC[C@@H](O)CCCCCC)OC(=O)CCCCCCCC=CC[C@H](O)CCCCCC ZEMPKEQAKRGZGQ-XOQCFJPHSA-N 0.000 claims description 17
- 229940100554 isononyl isononanoate Drugs 0.000 claims description 17
- 229940070765 laurate Drugs 0.000 claims description 17
- 235000010445 lecithin Nutrition 0.000 claims description 17
- 229940067606 lecithin Drugs 0.000 claims description 17
- 239000000787 lecithin Substances 0.000 claims description 17
- WWZKQHOCKIZLMA-UHFFFAOYSA-N octanoic acid Chemical compound CCCCCCCC(O)=O WWZKQHOCKIZLMA-UHFFFAOYSA-N 0.000 claims description 17
- LADGBHLMCUINGV-UHFFFAOYSA-N tricaprin Chemical compound CCCCCCCCCC(=O)OCC(OC(=O)CCCCCCCCC)COC(=O)CCCCCCCCC LADGBHLMCUINGV-UHFFFAOYSA-N 0.000 claims description 17
- 238000010438 heat treatment Methods 0.000 claims description 12
- 238000004945 emulsification Methods 0.000 claims description 11
- WCVRQHFDJLLWFE-UHFFFAOYSA-N pentane-1,2-diol Chemical compound CCCC(O)CO WCVRQHFDJLLWFE-UHFFFAOYSA-N 0.000 claims description 10
- 238000003756 stirring Methods 0.000 claims description 10
- 238000000265 homogenisation Methods 0.000 claims description 9
- 238000006243 chemical reaction Methods 0.000 claims description 8
- 238000010008 shearing Methods 0.000 claims description 7
- ASKIVFGGGGIGKH-UHFFFAOYSA-N 2,3-dihydroxypropyl 16-methylheptadecanoate Chemical compound CC(C)CCCCCCCCCCCCCCC(=O)OCC(O)CO ASKIVFGGGGIGKH-UHFFFAOYSA-N 0.000 claims description 4
- POJWUDADGALRAB-UHFFFAOYSA-N allantoin Chemical compound NC(=O)NC1NC(=O)NC1=O POJWUDADGALRAB-UHFFFAOYSA-N 0.000 claims description 4
- 239000006071 cream Substances 0.000 claims description 4
- BXWNKGSJHAJOGX-UHFFFAOYSA-N hexadecan-1-ol Chemical compound CCCCCCCCCCCCCCCCO BXWNKGSJHAJOGX-UHFFFAOYSA-N 0.000 claims description 4
- JVTAAEKCZFNVCJ-UHFFFAOYSA-N lactic acid Chemical compound CC(O)C(O)=O JVTAAEKCZFNVCJ-UHFFFAOYSA-N 0.000 claims description 4
- 238000005086 pumping Methods 0.000 claims description 4
- 238000004383 yellowing Methods 0.000 claims description 4
- -1 isopropyl lanolate Chemical compound 0.000 claims description 3
- 239000006210 lotion Substances 0.000 claims description 3
- 150000008442 polyphenolic compounds Chemical class 0.000 claims description 3
- 235000013824 polyphenols Nutrition 0.000 claims description 3
- KIUKXJAPPMFGSW-DNGZLQJQSA-N (2S,3S,4S,5R,6R)-6-[(2S,3R,4R,5S,6R)-3-Acetamido-2-[(2S,3S,4R,5R,6R)-6-[(2R,3R,4R,5S,6R)-3-acetamido-2,5-dihydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-2-carboxy-4,5-dihydroxyoxan-3-yl]oxy-5-hydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-3,4,5-trihydroxyoxane-2-carboxylic acid Chemical compound CC(=O)N[C@H]1[C@H](O)O[C@H](CO)[C@@H](O)[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@H](O[C@H]2[C@@H]([C@@H](O[C@H]3[C@@H]([C@@H](O)[C@H](O)[C@H](O3)C(O)=O)O)[C@H](O)[C@@H](CO)O2)NC(C)=O)[C@@H](C(O)=O)O1 KIUKXJAPPMFGSW-DNGZLQJQSA-N 0.000 claims description 2
- ILCOCZBHMDEIAI-UHFFFAOYSA-N 2-(2-octadecoxyethoxy)ethanol Chemical compound CCCCCCCCCCCCCCCCCCOCCOCCO ILCOCZBHMDEIAI-UHFFFAOYSA-N 0.000 claims description 2
- XZIIFPSPUDAGJM-UHFFFAOYSA-N 6-chloro-2-n,2-n-diethylpyrimidine-2,4-diamine Chemical compound CCN(CC)C1=NC(N)=CC(Cl)=N1 XZIIFPSPUDAGJM-UHFFFAOYSA-N 0.000 claims description 2
- POJWUDADGALRAB-PVQJCKRUSA-N Allantoin Natural products NC(=O)N[C@@H]1NC(=O)NC1=O POJWUDADGALRAB-PVQJCKRUSA-N 0.000 claims description 2
- YDNKGFDKKRUKPY-JHOUSYSJSA-N C16 ceramide Natural products CCCCCCCCCCCCCCCC(=O)N[C@@H](CO)[C@H](O)C=CCCCCCCCCCCCCC YDNKGFDKKRUKPY-JHOUSYSJSA-N 0.000 claims description 2
- ACTIUHUUMQJHFO-UHFFFAOYSA-N Coenzym Q10 Natural products COC1=C(OC)C(=O)C(CC=C(C)CCC=C(C)CCC=C(C)CCC=C(C)CCC=C(C)CCC=C(C)CCC=C(C)CCC=C(C)CCC=C(C)CCC=C(C)C)=C(C)C1=O ACTIUHUUMQJHFO-UHFFFAOYSA-N 0.000 claims description 2
- CRJGESKKUOMBCT-VQTJNVASSA-N N-acetylsphinganine Chemical compound CCCCCCCCCCCCCCC[C@@H](O)[C@H](CO)NC(C)=O CRJGESKKUOMBCT-VQTJNVASSA-N 0.000 claims description 2
- QNVSXXGDAPORNA-UHFFFAOYSA-N Resveratrol Natural products OC1=CC=CC(C=CC=2C=C(O)C(O)=CC=2)=C1 QNVSXXGDAPORNA-UHFFFAOYSA-N 0.000 claims description 2
- LUKBXSAWLPMMSZ-OWOJBTEDSA-N Trans-resveratrol Chemical compound C1=CC(O)=CC=C1\C=C\C1=CC(O)=CC(O)=C1 LUKBXSAWLPMMSZ-OWOJBTEDSA-N 0.000 claims description 2
- 235000009754 Vitis X bourquina Nutrition 0.000 claims description 2
- 235000012333 Vitis X labruscana Nutrition 0.000 claims description 2
- 240000006365 Vitis vinifera Species 0.000 claims description 2
- 235000014787 Vitis vinifera Nutrition 0.000 claims description 2
- 229960000458 allantoin Drugs 0.000 claims description 2
- 229940106189 ceramide Drugs 0.000 claims description 2
- ZVEQCJWYRWKARO-UHFFFAOYSA-N ceramide Natural products CCCCCCCCCCCCCCC(O)C(=O)NC(CO)C(O)C=CCCC=C(C)CCCCCCCCC ZVEQCJWYRWKARO-UHFFFAOYSA-N 0.000 claims description 2
- 229960000541 cetyl alcohol Drugs 0.000 claims description 2
- 235000017471 coenzyme Q10 Nutrition 0.000 claims description 2
- ACTIUHUUMQJHFO-UPTCCGCDSA-N coenzyme Q10 Chemical compound COC1=C(OC)C(=O)C(C\C=C(/C)CC\C=C(/C)CC\C=C(/C)CC\C=C(/C)CC\C=C(/C)CC\C=C(/C)CC\C=C(/C)CC\C=C(/C)CC\C=C(/C)CCC=C(C)C)=C(C)C1=O ACTIUHUUMQJHFO-UPTCCGCDSA-N 0.000 claims description 2
- 229940110767 coenzyme Q10 Drugs 0.000 claims description 2
- 229920001577 copolymer Polymers 0.000 claims description 2
- SFNALCNOMXIBKG-UHFFFAOYSA-N ethylene glycol monododecyl ether Chemical compound CCCCCCCCCCCCOCCO SFNALCNOMXIBKG-UHFFFAOYSA-N 0.000 claims description 2
- 229940074052 glyceryl isostearate Drugs 0.000 claims description 2
- 229920002674 hyaluronan Polymers 0.000 claims description 2
- 229960003160 hyaluronic acid Drugs 0.000 claims description 2
- XUGNVMKQXJXZCD-UHFFFAOYSA-N isopropyl palmitate Chemical compound CCCCCCCCCCCCCCCC(=O)OC(C)C XUGNVMKQXJXZCD-UHFFFAOYSA-N 0.000 claims description 2
- 229940075495 isopropyl palmitate Drugs 0.000 claims description 2
- 235000014655 lactic acid Nutrition 0.000 claims description 2
- 239000004310 lactic acid Substances 0.000 claims description 2
- 229960000448 lactic acid Drugs 0.000 claims description 2
- 229940100556 laureth-23 Drugs 0.000 claims description 2
- AGBQKNBQESQNJD-UHFFFAOYSA-M lipoate Chemical compound [O-]C(=O)CCCCC1CCSS1 AGBQKNBQESQNJD-UHFFFAOYSA-M 0.000 claims description 2
- 235000019136 lipoic acid Nutrition 0.000 claims description 2
- VVGIYYKRAMHVLU-UHFFFAOYSA-N newbouldiamide Natural products CCCCCCCCCCCCCCCCCCCC(O)C(O)C(O)C(CO)NC(=O)CCCCCCCCCCCCCCCCC VVGIYYKRAMHVLU-UHFFFAOYSA-N 0.000 claims description 2
- 235000021283 resveratrol Nutrition 0.000 claims description 2
- 229940016667 resveratrol Drugs 0.000 claims description 2
- 229940035044 sorbitan monolaurate Drugs 0.000 claims description 2
- 229940098760 steareth-2 Drugs 0.000 claims description 2
- 229960002663 thioctic acid Drugs 0.000 claims description 2
- DNIAPMSPPWPWGF-VKHMYHEASA-N (+)-propylene glycol Chemical compound C[C@H](O)CO DNIAPMSPPWPWGF-VKHMYHEASA-N 0.000 claims 1
- BQMNFPBUAQPINY-UHFFFAOYSA-N azane;2-methyl-2-(prop-2-enoylamino)propane-1-sulfonic acid Chemical compound [NH4+].[O-]S(=O)(=O)CC(C)(C)NC(=O)C=C BQMNFPBUAQPINY-UHFFFAOYSA-N 0.000 claims 1
- 229920000166 polytrimethylene carbonate Polymers 0.000 claims 1
- 230000003078 antioxidant effect Effects 0.000 abstract description 7
- 230000000694 effects Effects 0.000 abstract description 7
- 238000010521 absorption reaction Methods 0.000 abstract description 5
- 239000004480 active ingredient Substances 0.000 abstract description 5
- 239000003963 antioxidant agent Substances 0.000 abstract description 5
- 238000004090 dissolution Methods 0.000 abstract description 5
- 230000002087 whitening effect Effects 0.000 abstract description 5
- 238000002425 crystallisation Methods 0.000 abstract description 4
- 230000008025 crystallization Effects 0.000 abstract description 4
- 238000005286 illumination Methods 0.000 abstract description 4
- 239000002537 cosmetic Substances 0.000 abstract description 2
- 230000000052 comparative effect Effects 0.000 description 6
- 239000000047 product Substances 0.000 description 5
- JLPULHDHAOZNQI-ZTIMHPMXSA-N 1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine Chemical compound CCCCCCCCCCCCCCCC(=O)OC[C@H](COP([O-])(=O)OCC[N+](C)(C)C)OC(=O)CCCCCCC\C=C/C\C=C/CCCCC JLPULHDHAOZNQI-ZTIMHPMXSA-N 0.000 description 3
- ZDQWESQEGGJUCH-UHFFFAOYSA-N Diisopropyl adipate Chemical compound CC(C)OC(=O)CCCCC(=O)OC(C)C ZDQWESQEGGJUCH-UHFFFAOYSA-N 0.000 description 3
- 235000006708 antioxidants Nutrition 0.000 description 3
- 235000013399 edible fruits Nutrition 0.000 description 3
- 230000009759 skin aging Effects 0.000 description 3
- 230000032683 aging Effects 0.000 description 2
- 230000003064 anti-oxidating effect Effects 0.000 description 2
- 239000000839 emulsion Substances 0.000 description 2
- 230000001815 facial effect Effects 0.000 description 2
- 239000002245 particle Substances 0.000 description 2
- 238000001556 precipitation Methods 0.000 description 2
- 229920000832 Cutin Polymers 0.000 description 1
- 102000004190 Enzymes Human genes 0.000 description 1
- 108090000790 Enzymes Proteins 0.000 description 1
- NIPNSKYNPDTRPC-UHFFFAOYSA-N N-[2-oxo-2-(2,4,6,7-tetrahydrotriazolo[4,5-c]pyridin-5-yl)ethyl]-2-[[3-(trifluoromethoxy)phenyl]methylamino]pyrimidine-5-carboxamide Chemical compound O=C(CNC(=O)C=1C=NC(=NC=1)NCC1=CC(=CC=C1)OC(F)(F)F)N1CC2=C(CC1)NN=N2 NIPNSKYNPDTRPC-UHFFFAOYSA-N 0.000 description 1
- AFCARXCZXQIEQB-UHFFFAOYSA-N N-[3-oxo-3-(2,4,6,7-tetrahydrotriazolo[4,5-c]pyridin-5-yl)propyl]-2-[[3-(trifluoromethoxy)phenyl]methylamino]pyrimidine-5-carboxamide Chemical compound O=C(CCNC(=O)C=1C=NC(=NC=1)NCC1=CC(=CC=C1)OC(F)(F)F)N1CC2=C(CC1)NN=N2 AFCARXCZXQIEQB-UHFFFAOYSA-N 0.000 description 1
- 244000044822 Simmondsia californica Species 0.000 description 1
- 235000004433 Simmondsia californica Nutrition 0.000 description 1
- 208000000453 Skin Neoplasms Diseases 0.000 description 1
- 239000003463 adsorbent Substances 0.000 description 1
- 239000001140 aloe barbadensis leaf extract Substances 0.000 description 1
- 239000008163 avocado oil Substances 0.000 description 1
- 235000021302 avocado oil Nutrition 0.000 description 1
- 230000004888 barrier function Effects 0.000 description 1
- 229940119217 chamomile extract Drugs 0.000 description 1
- 235000020221 chamomile extract Nutrition 0.000 description 1
- 239000011248 coating agent Substances 0.000 description 1
- 238000000576 coating method Methods 0.000 description 1
- GVJHHUAWPYXKBD-UHFFFAOYSA-N d-alpha-tocopherol Natural products OC1=C(C)C(C)=C2OC(CCCC(C)CCCC(C)CCCC(C)C)(C)CCC2=C1C GVJHHUAWPYXKBD-UHFFFAOYSA-N 0.000 description 1
- 238000005189 flocculation Methods 0.000 description 1
- 230000016615 flocculation Effects 0.000 description 1
- 229910052739 hydrogen Inorganic materials 0.000 description 1
- 239000001257 hydrogen Substances 0.000 description 1
- 230000002401 inhibitory effect Effects 0.000 description 1
- 230000014759 maintenance of location Effects 0.000 description 1
- 239000002207 metabolite Substances 0.000 description 1
- 238000000034 method Methods 0.000 description 1
- 230000002906 microbiologic effect Effects 0.000 description 1
- 230000003020 moisturizing effect Effects 0.000 description 1
- 239000002539 nanocarrier Substances 0.000 description 1
- 239000003921 oil Substances 0.000 description 1
- 235000019198 oils Nutrition 0.000 description 1
- 230000003647 oxidation Effects 0.000 description 1
- 238000007254 oxidation reaction Methods 0.000 description 1
- 239000012466 permeate Substances 0.000 description 1
- 201000000849 skin cancer Diseases 0.000 description 1
- FWFUWXVFYKCSQA-UHFFFAOYSA-M sodium;2-methyl-2-(prop-2-enoylamino)propane-1-sulfonate Chemical compound [Na+].[O-]S(=O)(=O)CC(C)(C)NC(=O)C=C FWFUWXVFYKCSQA-UHFFFAOYSA-M 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 208000024891 symptom Diseases 0.000 description 1
- 239000011732 tocopherol Substances 0.000 description 1
- 235000010384 tocopherol Nutrition 0.000 description 1
- 229960001295 tocopherol Drugs 0.000 description 1
- 229930003799 tocopherol Natural products 0.000 description 1
- 231100000167 toxic agent Toxicity 0.000 description 1
- 239000003440 toxic substance Substances 0.000 description 1
- 235000015112 vegetable and seed oil Nutrition 0.000 description 1
- 239000002699 waste material Substances 0.000 description 1
- GVJHHUAWPYXKBD-IEOSBIPESA-N α-tocopherol Chemical compound OC1=C(C)C(C)=C2O[C@@](CCC[C@H](C)CCC[C@H](C)CCCC(C)C)(C)CCC2=C1C GVJHHUAWPYXKBD-IEOSBIPESA-N 0.000 description 1
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- Cosmetics (AREA)
Abstract
The invention relates to the technical field of cosmetics, and specifically relates to a nano-scale yellow-removing composition containing tetrahydrocurcumin and a preparation method thereof, wherein the nano-scale yellow-removing composition containing tetrahydrocurcumin comprises the following preparation raw materials in percentage by weight: 23-28% of humectant, 7-11% of emollient, 5-9% of repairing agent, 10-15% of solubilizer and the balance of water to 100%. The nano-scale yellow-removing composition containing the tetrahydrocurcumin is prepared by mixing the humectant, the water, the emollient, the repairing agent and the solubilizer, has excellent physicochemical stability, can effectively inhibit the crystallization of the tetrahydrocurcumin, effectively solves the problems of no high temperature resistance and unstable illumination, has high dissolution rate and absorption rate of active ingredients of the prepared composition, can effectively inhibit the generation of free radicals in skin, can remove the generated free radicals, and has excellent whitening, antioxidant and yellow-removing effects.
Description
Technical Field
The invention relates to the technical field of cosmetics, has an IPC classification number of A61K, and particularly relates to a nano-scale yellow-dispelling composition containing tetrahydrocurcumin and a preparation method thereof.
Background
The skin is the first barrier of a human body and can reflect the aging condition of the body, cells can be oxidized to generate free radicals due to oxidation pressure generated by ultraviolet irradiation, haze and the like in the external environment, the skin aging is accelerated, skin cancer is caused, the activity of antioxidant enzyme can be improved by inhibiting the generation of the free radicals in the skin and removing aging metabolites generated in the skin, the skin aging can be effectively inhibited, and the skin aging symptom can be effectively relieved by selecting a proper skin care product.
Patent CN201510710450.4 discloses an anti-oxidation skin care product of red fruit, which is prepared by extracting red fruit to obtain an extract rich in polyphenols, and has good anti-oxidation effect, fine and soft skin care product, good spreadability and poor absorption rate.
Patent CN201910339965.6 discloses a skin care product with moisturizing, soothing and antioxidant effects and a preparation method and application thereof, and raw materials for preparing the skin care product comprise Mao Ruilv fruit oil, jojoba seed oil, avocado oil, tocopherol, an aloe barbadensis leaf extract, a chamomile extract and the like.
Therefore, it is necessary to develop a composition which has stable physicochemical properties, high dissolution rate and absorption rate of active ingredients, can effectively inhibit the generation of free radicals in the skin, can remove the generated free radicals, and has excellent whitening, antioxidant and yellow removing effects.
Disclosure of Invention
The invention provides a nano-scale yellow-removing composition containing tetrahydrocurcumin, which comprises the following raw materials in percentage by weight: 23-28% of humectant, 7-11% of emollient, 5-9% of repairing agent, 10-15% of solubilizer and the balance of water to 100%.
Preferably, the humectant comprises 1,3-propylene glycol, 1,2-pentanediol, ceramide, hyaluronic acid, lactic acid and allantoin or a combination of several of the same;
further preferably, the humectant is a compound of 1,3-propylene glycol and 1,2-pentanediol, and the mass ratio of 1,3-propylene glycol to 1,2-pentanediol is 1-2:1;
preferably, the emollient comprises one or more of caprylic/capric triglyceride, isononyl isononanoate, isopropyl palmitate, cetyl alcohol, isopropyl lanolate, diisopropyl adipate and glyceryl isostearate;
further preferably, the emollient is a compound of caprylic/capric triglyceride, isononyl isononanoate and diisopropyl adipate, and the mass ratio of caprylic/capric triglyceride, isononyl isononanoate and diisopropyl adipate is 7-9:1:0.5-0.7;
preferably, the repairing agent comprises one or a combination of more of tetrahydrocurcumin, lecithin, resveratrol, coenzyme Q10, grape polyphenol and lipoic acid;
further preferably, the repairing agent is a compound of tetrahydrocurcumin and lecithin, and the mass ratio of the tetrahydrocurcumin to the lecithin is (2-3): 1;
preferably, the solubilizer comprises one or more of PEG-40 hydrogenated castor oil, polyglycerol-10 laurate, octyldodecanol, acryloyl dimethyl taurate/VP copolymer, polyglycerol-6-distearate, laureth-23, steareth-2 and sorbitan monolaurate;
further preferably, the solubilizer is a compound of PEG-40 hydrogenated castor oil, polyglycerol-10 laurate and octyldodecanol, wherein the mass ratio of the PEG-40 hydrogenated castor oil to the polyglycerol-10 laurate to the octyldodecanol is 7-9:2-4:1-3.
The second aspect of the invention provides a preparation method of a nano-scale yellow-removing composition containing tetrahydrocurcumin, which comprises the following steps:
(1) Adding a humectant and water into a reaction container, heating and stirring to obtain a mixed solution a for later use;
(2) Adding the emollient, the repairing agent and the solubilizer into another reaction vessel, heating and stirring to obtain a mixed solution b for later use;
(3) Mixing the mixed solution b with the mixed solution a, and performing shearing emulsification to prepare a mixed solution c;
(4) Pumping the mixed solution c into a high-pressure micro-jet extractor for homogenization treatment, homogenizing by two-stage high-pressure micro-jet, collecting the mixed solution after all the mixed solution c passes through the extractor, and preparing the nano-scale yellow-removing composition containing tetrahydrocurcumin.
The third aspect of the invention provides application of a nano-scale yellow-removing composition containing tetrahydrocurcumin, which is applied to cream, lotion, facial masks and essence.
Has the advantages that:
(1) According to the invention, the nano-scale yellow-removing composition containing tetrahydrocurcumin is prepared by mixing the humectant, the water, the emollient, the repairing agent and the solubilizer, has excellent physicochemical stability, can effectively inhibit the crystallization of the tetrahydrocurcumin, effectively solves the problems of no high temperature resistance and unstable illumination, has high dissolution rate and absorption rate of active ingredients of the prepared nano-scale composition, can effectively inhibit the generation of free radicals in skin, can remove the generated free radicals, and has excellent whitening, antioxidant and yellow-removing effects.
(2) The applicant finds that by adding the emollient, the compound is composed of caprylic/capric triglyceride, isononyl isononanoate and diisopropyl adipate, the mass ratio of the caprylic/capric triglyceride, the isononyl isononanoate and the diisopropyl adipate is 7-9:1:0.5-0.7, wherein the repairing agent is a compound of tetrahydrocurcumin and lecithin, and the mass ratio of the tetrahydrocurcumin to the lecithin is (2-3): 1, the solubilizer is the compound of PEG-40 hydrogenated castor oil, polyglycerol-10 laurate and octyl dodecanol, the mass ratio of the PEG-40 hydrogenated castor oil to the polyglycerol-10 laurate to the octyl dodecanol is 7-9:2-4:1-3, the physical and chemical stability of the prepared yellow-removing composition can be improved, the emollient, the repairing agent and the solubilizer are closely adsorbed and combined through intermolecular hydrogen bond action to form a stable coating structure, the problems of no high temperature resistance and unstable illumination of the composition can be effectively solved, the solubilizer can further promote the compatibility of the emollient and the adsorbent with other components in a system through strong intermolecular force, the crystallization of tetrahydrocurcumin can be effectively inhibited, the dissolution rate and the absorption rate of active ingredients of the prepared composition are high, the composition is particularly suitable for preparing cream, emulsion, facial mask, essence and the like, the composition is mixed with skin-care cream, emulsion and the like and is coated on skin, the generation of free radicals can be effectively inhibited, the composition has excellent whitening and antioxidant effects, waste cutin can be effectively removed, and the skin activity can be recovered.
(3) The humectant and water are mixed, heated and stirred to obtain a mixed solution a, the emollient, the repairing agent and the solubilizer are mixed, the mixed solution a and the mixed solution b are heated and stirred to obtain a mixed solution b, the mixed solution a and the mixed solution b are mixed, and a nano-carrier prepared by specific shearing emulsification and high-pressure micro-jet process can quickly permeate into deep tissues of skin, has good skin retention property and high absorptivity, has excellent physicochemical stability, effectively inhibits the crystallization precipitation of tetrahydrocurcumin, effectively improves the problems of no high temperature resistance and unstable illumination, has high dissolution rate and absorptivity of active ingredients, can effectively inhibit the generation of free radicals in the skin, eliminates the generated free radicals, and has excellent whitening, antioxidant and yellow removing effects.
Detailed Description
Example 1
Embodiment 1 provides a nano-scale yellow-removing composition containing tetrahydrocurcumin, which comprises the following raw materials in percentage by weight: 23% of humectant, 7% of emollient, 5% of repairing agent, 10% of solubilizer and the balance of water to 100%.
The humectant is compounded by 1,3-propylene glycol and 1,2-pentanediol, and the mass ratio of 1,3-propylene glycol to 1,2-pentanediol is 1:1;
the emollient is a compound of caprylic/capric triglyceride, isononyl isononanoate and diisopropyl adipate, and the mass ratio of the caprylic/capric triglyceride, the isononyl isononanoate and the diisopropyl adipate is 7:1:0.5, caprylic/capric triglyceride CAS number 65381-09-1, isononyl isononanoate CAS number 42131-25-9, diisopropyl adipate CAS number 6938-94-9;
the repairing agent is a compound of tetrahydrocurcumin and lecithin, and the mass ratio of the tetrahydrocurcumin to the lecithin is 2:1, tetrahydrocurcumin CAS number 36062-04-1, lecithin CAS number 8002-43-5;
the solubilizer is a compound of PEG-40 hydrogenated castor oil, polyglycerol-10 laurate and octyl dodecanol, and the mass ratio of the PEG-40 hydrogenated castor oil to the polyglycerol-10 laurate to the octyl dodecanol is 7:2:1, PEG-40 hydrogenated Castor oil CAS number 61788-85-0, polyglycerol-10 laurate CAS number 34406-66-1, octyldodecanol CAS number 5333-42-6.
The second aspect of the invention provides a preparation method of a nano-scale yellow-removing composition containing tetrahydrocurcumin, which comprises the following steps:
(1) Adding a humectant and water into a reaction vessel, heating and stirring, and heating to 75 ℃ to obtain a mixed solution a for later use;
(2) Adding the emollient, the repairing agent and the solubilizer into another reaction vessel, heating and stirring, heating to 70 ℃, and stopping stirring to obtain a mixed solution b for later use;
(3) Mixing the mixed solution b with the mixed solution a, and carrying out shearing emulsification, wherein the shearing emulsification rate is 18000rpm, the shearing emulsification time is 8min, and the shearing emulsification temperature is 60 ℃ to prepare a mixed solution c;
(4) Pumping the mixed solution c into a high-pressure micro-jet extractor for homogenization treatment, homogenizing by two-stage high-pressure micro-jet with the homogenization interval time of 4min, and collecting the mixed solution after all the mixed solution c passes through the extractor to prepare the nano-scale yellow-removing composition containing tetrahydrocurcumin.
The first-stage homogenizing flow is 70mL/min, the homogenizing temperature is 45 ℃, and the homogenizing pressure is 90MPa;
the second-stage homogenizing flow is 95mL/min, the homogenizing temperature is 32 ℃, and the homogenizing pressure is 50MPa;
the high-pressure micro-jet extractor is a PSI40 type high-pressure micro-jet homogenizing extractor, and the producer is Italian PSI company;
the third aspect of the invention provides application of a nano-scale yellow-removing composition containing tetrahydrocurcumin, which is applied to essential water.
Example 2
Embodiment 2 provides a nano-scale yellow-removing composition containing tetrahydrocurcumin, which comprises the following raw materials in percentage by weight: 25% of humectant, 9% of emollient, 7% of repairing agent, 13% of solubilizer and water for balancing the balance to 100%.
The humectant is a compound of 1,3-propylene glycol and 1,2-pentanediol, and the mass ratio of 1,3-propylene glycol to 1,2-pentanediol is 1-2:1;
the emollient is a compound of caprylic/capric triglyceride, isononyl isononanoate and diisopropyl adipate, and the mass ratio of the caprylic/capric triglyceride, the isononyl isononanoate and the diisopropyl adipate is 8:1:0.6, caprylic/capric triglyceride CAS number 65381-09-1, isononyl isononanoate CAS number 42131-25-9, diisopropyl adipate CAS number 6938-94-9;
the repairing agent is a compound of tetrahydrocurcumin and lecithin, and the mass ratio of the tetrahydrocurcumin to the lecithin is (2.5): 1, tetrahydrocurcumin CAS number 36062-04-1, lecithin CAS number 8002-43-5;
the solubilizer is a compound of PEG-40 hydrogenated castor oil, polyglycerol-10 laurate and octyl dodecanol, and the mass ratio of the PEG-40 hydrogenated castor oil to the polyglycerol-10 laurate to the octyl dodecanol is 8:3:2, PEG-40 hydrogenated Castor oil CAS number 61788-85-0, polyglycerol-10 laurate CAS number 34406-66-1, and octyldodecanol CAS number 5333-42-6.
The second aspect of the invention provides a preparation method of a nano-scale yellow-removing composition containing tetrahydrocurcumin, which comprises the following steps:
(1) Adding a humectant and water into a reaction container, heating and stirring, and heating to 80 ℃ to obtain a mixed solution a for later use;
(2) Adding the emollient, the repairing agent and the solubilizer into another reaction vessel, heating and stirring, heating to 80 ℃, and stopping stirring to obtain a mixed solution b for later use;
(3) Mixing the mixed solution b with the mixed solution a, and carrying out shear emulsification, wherein the shear emulsification rate is 20000rpm, the shear emulsification time is 10min, and the shear emulsification temperature is 60 ℃ to prepare a mixed solution c;
(4) Pumping the mixed solution c into a high-pressure micro-jet extractor for homogenization treatment, homogenizing by two-stage high-pressure micro-jet with the homogenization interval time of 6min, and collecting the mixed solution after all the mixed solution c passes through the extractor to prepare the nano-scale yellow-removing composition containing tetrahydrocurcumin.
The first-stage homogenizing flow is 80mL/min, the homogenizing temperature is 55 ℃, and the homogenizing pressure is 95MPa;
the flow rate of the second-stage homogenization is 95mL/min, the homogenization temperature is 35 ℃, and the homogenization pressure is 60MPa;
the high-pressure micro-jet extractor is a PSI40 type high-pressure micro-jet homogenizing extractor, and the producer is Italian PSI company;
the third aspect of the invention provides application of a nano-scale yellow-removing composition containing tetrahydrocurcumin, which is applied to essential water.
Comparative example 1
The specific implementation mode is the same as that of example 2, except that the emollient is a compound of caprylic/capric triglyceride, isononyl isononanoate and diisopropyl adipate, and the mass ratio of the caprylic/capric triglyceride, the isononyl isononanoate and the diisopropyl adipate is 0.3:0.1:0.5, caprylic/capric triglyceride CAS number 65381-09-1, isononyl isononanoate CAS number 42131-25-9, diisopropyl adipate CAS number 6938-94-9.
Comparative example 2
The specific implementation manner is the same as that in example 2, except that the repairing agent is a compound of tetrahydrocurcumin and lecithin, and the mass ratio of the tetrahydrocurcumin to the lecithin is 0.3:1, tetrahydrocurcumin CAS number 36062-04-1, lecithin CAS number 8002-43-5.
Comparative example 3
The specific implementation manner is the same as that in example 2, except that the solubilizer is a compound of PEG-40 hydrogenated castor oil, polyglycerol-10 laurate and octyldodecanol, and the mass ratio of the PEG-40 hydrogenated castor oil, the polyglycerol-10 laurate and the octyldodecanol is 0.5:0.3:1, PEG-40 hydrogenated castor oil CAS number 61788-85-0, polyglycerol-10 laurate CAS number 34406-66-1, octyldodecanol CAS number 5333-42-6.
Performance testing
The particle size of the nano-scale yellow-removing composition prepared in the example 1-2 and the comparative example 1-3 is tested by an LS-909 type laser particle size analyzer;
the nanoscale anti-yellowing compositions prepared in examples 1-2 and comparative examples 1-3 were tested for pH, appearance, toxic substance limits, and microbiological indicators according to standard QB/T2660-2004 lotions.
The nano-scale yellow-removing composition prepared in the examples 1-2 and the comparative examples 1-3 is respectively placed at the temperature of (40 +/-1) DEG C and (-5 +/-1) DEG C for 24 hours, taken out and then returned to the room temperature, and whether the nano-scale yellow-removing composition containing the tetrahydrocurcumin has the phenomena of layering, flocculation and precipitation is observed.
Claims (10)
1. The nano-scale yellow-removing composition containing tetrahydrocurcumin is characterized by comprising the following preparation raw materials in percentage by weight: 23-28% of a humectant, 7-11% of an emollient, 5-9% of a repairing agent, 10-15% of a solubilizer and water, wherein the balance of water is up to 100%, and the repairing agent comprises one or more of tetrahydrocurcumin, lecithin, resveratrol, coenzyme Q10, grape polyphenol and lipoic acid.
2. The nano-scale yellow-removing composition containing tetrahydrocurcumin as claimed in claim 1, wherein said humectant comprises 1,3-propanediol, 1,2-pentanediol, ceramide, hyaluronic acid, lactic acid, allantoin or their combination.
3. The nanoscale anti-yellowing composition containing tetrahydrocurcumin as claimed in claim 1 or 2, wherein the humectant is a combination of 1,3-propylene glycol and 1,2-pentanediol, and the mass ratio of 1,3-propylene glycol to 1,2-pentanediol is 1-2:1.
4. the nano-scale anti-yellowing composition according to claim 1, comprising tetrahydrocurcumin, wherein the emollient comprises one or more of caprylic/capric triglyceride, isononyl isononanoate, isopropyl palmitate, cetyl alcohol, isopropyl lanolate, diisopropyl adipate, and glyceryl isostearate.
5. The nano-scale yellow-removing composition containing tetrahydrocurcumin as claimed in claim 3, wherein the emollient is a compound of caprylic/capric triglyceride, isononyl isononanoate and diisopropyl adipate, and the mass ratio of caprylic/capric triglyceride, isononyl isononanoate and diisopropyl adipate is 7-9:1:0.5-0.7.
6. The nano-scale yellow-removing composition containing tetrahydrocurcumin as claimed in claim 1, wherein the repairing agent is a compound of tetrahydrocurcumin and lecithin, and the mass ratio of the tetrahydrocurcumin to the lecithin is (2-3): 1.
7. the nano-scale yellow removal composition containing tetrahydrocurcumin as claimed in claim 1, wherein said solubilizer comprises one or more of PEG-40 hydrogenated castor oil, polyglycerol-10 laurate, octyldodecanol, ammonium acryloyldimethyltaurate/VP copolymer, polyglycerol-6-distearate, laureth-23, steareth-2, sorbitan monolaurate.
8. The nano-scale yellow-removing composition containing tetrahydrocurcumin as claimed in claim 7, wherein the solubilizer is a complex of PEG-40 hydrogenated castor oil, polyglycerol-10 laurate and octyldodecanol, and the mass ratio of the PEG-40 hydrogenated castor oil, the polyglycerol-10 laurate and the octyldodecanol is 7-9:2-4:1-3.
9. The application of the nano-scale yellow-removing composition containing tetrahydrocurcumin according to any one of claims 1 to 8, which is applied to cream, lotion, mask and essence.
10. The preparation method of the nano-scale anti-yellowing composition containing tetrahydrocurcumin as claimed in any one of claims 1 to 8, characterized by comprising the following steps:
(1) Adding a humectant and water into a reaction container, heating and stirring to obtain a mixed solution a for later use;
(2) Adding the emollient, the repairing agent and the solubilizer into another reaction vessel, heating and stirring to obtain a mixed solution b for later use;
(3) Mixing the mixed solution b with the mixed solution a, and performing shearing emulsification to prepare a mixed solution c;
(4) Pumping the mixed solution c into a high-pressure micro-jet extractor for homogenization treatment, homogenizing by two-stage high-pressure micro-jet, collecting the mixed solution after all the mixed solution c passes through the extractor, and preparing the nano-scale yellow-removing composition containing tetrahydrocurcumin.
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