CN115836985A - Water-soluble retinol palmitate composition and preparation method thereof - Google Patents
Water-soluble retinol palmitate composition and preparation method thereof Download PDFInfo
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- VYGQUTWHTHXGQB-FFHKNEKCSA-N Retinol Palmitate Chemical compound CCCCCCCCCCCCCCCC(=O)OC\C=C(/C)\C=C\C=C(/C)\C=C\C1=C(C)CCCC1(C)C VYGQUTWHTHXGQB-FFHKNEKCSA-N 0.000 title claims abstract description 113
- 235000019172 retinyl palmitate Nutrition 0.000 title claims abstract description 55
- 229940108325 retinyl palmitate Drugs 0.000 title claims abstract description 55
- 239000011769 retinyl palmitate Substances 0.000 title claims abstract description 55
- 239000000203 mixture Substances 0.000 title claims abstract description 42
- 238000002360 preparation method Methods 0.000 title claims abstract description 11
- 239000011259 mixed solution Substances 0.000 claims abstract description 46
- 239000002270 dispersing agent Substances 0.000 claims abstract description 25
- -1 alcohol compound Chemical class 0.000 claims abstract description 22
- 239000003381 stabilizer Substances 0.000 claims abstract description 18
- 239000004902 Softening Agent Substances 0.000 claims abstract description 15
- 239000003795 chemical substances by application Substances 0.000 claims abstract description 13
- 230000003750 conditioning effect Effects 0.000 claims abstract description 9
- 238000005086 pumping Methods 0.000 claims abstract description 7
- 239000002994 raw material Substances 0.000 claims abstract description 7
- WWZKQHOCKIZLMA-UHFFFAOYSA-N octanoic acid Chemical compound CCCCCCCC(O)=O WWZKQHOCKIZLMA-UHFFFAOYSA-N 0.000 claims description 22
- UIVPNOBLHXUKDX-UHFFFAOYSA-N 3,5,5-trimethylhexyl 3,5,5-trimethylhexanoate Chemical compound CC(C)(C)CC(C)CCOC(=O)CC(C)CC(C)(C)C UIVPNOBLHXUKDX-UHFFFAOYSA-N 0.000 claims description 20
- 229940100554 isononyl isononanoate Drugs 0.000 claims description 17
- 229940105132 myristate Drugs 0.000 claims description 17
- 239000000244 polyoxyethylene sorbitan monooleate Substances 0.000 claims description 17
- 235000010482 polyoxyethylene sorbitan monooleate Nutrition 0.000 claims description 17
- 229940068968 polysorbate 80 Drugs 0.000 claims description 17
- 229920000053 polysorbate 80 Polymers 0.000 claims description 17
- TUNFSRHWOTWDNC-UHFFFAOYSA-N tetradecanoic acid Chemical compound CCCCCCCCCCCCCC(O)=O TUNFSRHWOTWDNC-UHFFFAOYSA-N 0.000 claims description 17
- LADGBHLMCUINGV-UHFFFAOYSA-N tricaprin Chemical compound CCCCCCCCCC(=O)OCC(OC(=O)CCCCCCCCC)COC(=O)CCCCCCCCC LADGBHLMCUINGV-UHFFFAOYSA-N 0.000 claims description 17
- IIZPXYDJLKNOIY-JXPKJXOSSA-N 1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphocholine Chemical class CCCCCCCCCCCCCCCC(=O)OC[C@H](COP([O-])(=O)OCC[N+](C)(C)C)OC(=O)CCC\C=C/C\C=C/C\C=C/C\C=C/CCCCC IIZPXYDJLKNOIY-JXPKJXOSSA-N 0.000 claims description 16
- ZAKOWWREFLAJOT-CEFNRUSXSA-N D-alpha-tocopherylacetate Chemical compound CC(=O)OC1=C(C)C(C)=C2O[C@@](CCC[C@H](C)CCC[C@H](C)CCCC(C)C)(C)CCC2=C1C ZAKOWWREFLAJOT-CEFNRUSXSA-N 0.000 claims description 16
- 238000004945 emulsification Methods 0.000 claims description 15
- YPFDHNVEDLHUCE-UHFFFAOYSA-N 1,3-propanediol Substances OCCCO YPFDHNVEDLHUCE-UHFFFAOYSA-N 0.000 claims description 13
- 238000010438 heat treatment Methods 0.000 claims description 13
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- 238000010008 shearing Methods 0.000 claims description 11
- 238000006243 chemical reaction Methods 0.000 claims description 10
- NLZUEZXRPGMBCV-UHFFFAOYSA-N Butylhydroxytoluene Chemical compound CC1=CC(C(C)(C)C)=C(O)C(C(C)(C)C)=C1 NLZUEZXRPGMBCV-UHFFFAOYSA-N 0.000 claims description 9
- 239000003974 emollient agent Substances 0.000 claims description 8
- 238000003756 stirring Methods 0.000 claims description 8
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- 238000000034 method Methods 0.000 claims description 7
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 claims description 6
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- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 4
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- 239000006210 lotion Substances 0.000 claims description 3
- 229920000166 polytrimethylene carbonate Polymers 0.000 claims description 3
- QMMJWQMCMRUYTG-UHFFFAOYSA-N 1,2,4,5-tetrachloro-3-(trifluoromethyl)benzene Chemical compound FC(F)(F)C1=C(Cl)C(Cl)=CC(Cl)=C1Cl QMMJWQMCMRUYTG-UHFFFAOYSA-N 0.000 claims description 2
- HIQIXEFWDLTDED-UHFFFAOYSA-N 4-hydroxy-1-piperidin-4-ylpyrrolidin-2-one Chemical compound O=C1CC(O)CN1C1CCNCC1 HIQIXEFWDLTDED-UHFFFAOYSA-N 0.000 claims description 2
- 229940100484 5-chloro-2-methyl-4-isothiazolin-3-one Drugs 0.000 claims description 2
- ODHCTXKNWHHXJC-VKHMYHEASA-M 5-oxo-L-prolinate Chemical compound [O-]C(=O)[C@@H]1CCC(=O)N1 ODHCTXKNWHHXJC-VKHMYHEASA-M 0.000 claims description 2
- FBPFZTCFMRRESA-FSIIMWSLSA-N D-Glucitol Natural products OC[C@H](O)[C@H](O)[C@@H](O)[C@H](O)CO FBPFZTCFMRRESA-FSIIMWSLSA-N 0.000 claims description 2
- FBPFZTCFMRRESA-JGWLITMVSA-N D-glucitol Chemical compound OC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-JGWLITMVSA-N 0.000 claims description 2
- 229920001213 Polysorbate 20 Polymers 0.000 claims description 2
- DBMJMQXJHONAFJ-UHFFFAOYSA-M Sodium laurylsulphate Chemical compound [Na+].CCCCCCCCCCCCOS([O-])(=O)=O DBMJMQXJHONAFJ-UHFFFAOYSA-M 0.000 claims description 2
- DHNRXBZYEKSXIM-UHFFFAOYSA-N chloromethylisothiazolinone Chemical compound CN1SC(Cl)=CC1=O DHNRXBZYEKSXIM-UHFFFAOYSA-N 0.000 claims description 2
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- ZCTXEAQXZGPWFG-UHFFFAOYSA-N imidurea Chemical compound O=C1NC(=O)N(CO)C1NC(=O)NCNC(=O)NC1C(=O)NC(=O)N1CO ZCTXEAQXZGPWFG-UHFFFAOYSA-N 0.000 claims description 2
- 229940074928 isopropyl myristate Drugs 0.000 claims description 2
- 108700019599 monomethylolglycine Proteins 0.000 claims description 2
- ZHALDANPYXAMJF-UHFFFAOYSA-N octadecanoate;tris(2-hydroxyethyl)azanium Chemical compound OCC[NH+](CCO)CCO.CCCCCCCCCCCCCCCCCC([O-])=O ZHALDANPYXAMJF-UHFFFAOYSA-N 0.000 claims description 2
- 229940113115 polyethylene glycol 200 Drugs 0.000 claims description 2
- 239000000256 polyoxyethylene sorbitan monolaurate Substances 0.000 claims description 2
- 235000010486 polyoxyethylene sorbitan monolaurate Nutrition 0.000 claims description 2
- 229940071139 pyrrolidone carboxylate Drugs 0.000 claims description 2
- 229940101011 sodium hydroxymethylglycinate Drugs 0.000 claims description 2
- 235000019333 sodium laurylsulphate Nutrition 0.000 claims description 2
- CITBNDNUEPMTFC-UHFFFAOYSA-M sodium;2-(hydroxymethylamino)acetate Chemical compound [Na+].OCNCC([O-])=O CITBNDNUEPMTFC-UHFFFAOYSA-M 0.000 claims description 2
- 239000000600 sorbitol Substances 0.000 claims description 2
- 229960002920 sorbitol Drugs 0.000 claims description 2
- 239000007921 spray Substances 0.000 claims description 2
- 229940029614 triethanolamine stearate Drugs 0.000 claims description 2
- UFTFJSFQGQCHQW-UHFFFAOYSA-N triformin Chemical compound O=COCC(OC=O)COC=O UFTFJSFQGQCHQW-UHFFFAOYSA-N 0.000 claims description 2
- 239000002537 cosmetic Substances 0.000 abstract description 4
- 238000002156 mixing Methods 0.000 abstract description 2
- 210000003491 skin Anatomy 0.000 description 26
- 150000001875 compounds Chemical class 0.000 description 15
- 230000000052 comparative effect Effects 0.000 description 8
- 239000005635 Caprylic acid (CAS 124-07-2) Substances 0.000 description 6
- ZAKOWWREFLAJOT-UHFFFAOYSA-N d-alpha-Tocopheryl acetate Natural products CC(=O)OC1=C(C)C(C)=C2OC(CCCC(C)CCCC(C)CCCC(C)C)(C)CCC2=C1C ZAKOWWREFLAJOT-UHFFFAOYSA-N 0.000 description 6
- 229960002446 octanoic acid Drugs 0.000 description 6
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- 239000004480 active ingredient Substances 0.000 description 3
- 239000003963 antioxidant agent Substances 0.000 description 3
- 230000003078 antioxidant effect Effects 0.000 description 3
- 235000006708 antioxidants Nutrition 0.000 description 3
- FOYKKGHVWRFIBD-UHFFFAOYSA-N gamma-tocopherol acetate Natural products CC(=O)OC1=C(C)C(C)=C2OC(CCCC(C)CCCC(C)CCCC(C)C)(C)CCC2=C1 FOYKKGHVWRFIBD-UHFFFAOYSA-N 0.000 description 3
- 230000014759 maintenance of location Effects 0.000 description 3
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- CIWBSHSKHKDKBQ-JLAZNSOCSA-N Ascorbic acid Chemical compound OC[C@H](O)[C@H]1OC(=O)C(O)=C1O CIWBSHSKHKDKBQ-JLAZNSOCSA-N 0.000 description 2
- 230000003647 oxidation Effects 0.000 description 2
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- DIGQNXIGRZPYDK-WKSCXVIASA-N (2R)-6-amino-2-[[2-[[(2S)-2-[[2-[[(2R)-2-[[(2S)-2-[[(2R,3S)-2-[[2-[[(2S)-2-[[2-[[(2S)-2-[[(2S)-2-[[(2R)-2-[[(2S,3S)-2-[[(2R)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[2-[[(2S)-2-[[(2R)-2-[[2-[[2-[[2-[(2-amino-1-hydroxyethylidene)amino]-3-carboxy-1-hydroxypropylidene]amino]-1-hydroxy-3-sulfanylpropylidene]amino]-1-hydroxyethylidene]amino]-1-hydroxy-3-sulfanylpropylidene]amino]-1,3-dihydroxypropylidene]amino]-1-hydroxyethylidene]amino]-1-hydroxypropylidene]amino]-1,3-dihydroxypropylidene]amino]-1,3-dihydroxypropylidene]amino]-1-hydroxy-3-sulfanylpropylidene]amino]-1,3-dihydroxybutylidene]amino]-1-hydroxy-3-sulfanylpropylidene]amino]-1-hydroxypropylidene]amino]-1,3-dihydroxypropylidene]amino]-1-hydroxyethylidene]amino]-1,5-dihydroxy-5-iminopentylidene]amino]-1-hydroxy-3-sulfanylpropylidene]amino]-1,3-dihydroxybutylidene]amino]-1-hydroxy-3-sulfanylpropylidene]amino]-1,3-dihydroxypropylidene]amino]-1-hydroxyethylidene]amino]-1-hydroxy-3-sulfanylpropylidene]amino]-1-hydroxyethylidene]amino]hexanoic acid Chemical compound C[C@@H]([C@@H](C(=N[C@@H](CS)C(=N[C@@H](C)C(=N[C@@H](CO)C(=NCC(=N[C@@H](CCC(=N)O)C(=NC(CS)C(=N[C@H]([C@H](C)O)C(=N[C@H](CS)C(=N[C@H](CO)C(=NCC(=N[C@H](CS)C(=NCC(=N[C@H](CCCCN)C(=O)O)O)O)O)O)O)O)O)O)O)O)O)O)O)N=C([C@H](CS)N=C([C@H](CO)N=C([C@H](CO)N=C([C@H](C)N=C(CN=C([C@H](CO)N=C([C@H](CS)N=C(CN=C(C(CS)N=C(C(CC(=O)O)N=C(CN)O)O)O)O)O)O)O)O)O)O)O)O DIGQNXIGRZPYDK-WKSCXVIASA-N 0.000 description 1
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Abstract
The invention relates to the technical field of cosmetics, and specifically relates to a water-soluble retinol palmitate composition with an IPC classification number of A61K and a preparation method thereof, wherein the water-soluble retinol palmitate composition comprises the following raw materials in percentage by weight: 25-32% of alcohol compound, 20-32% of dispersing agent, 9-13% of conditioning agent, 25-30% of softening agent and 0.1-0.3% of stabilizing agent. The water-soluble retinol palmitate composition is prepared by mixing an alcohol compound, a dispersing agent, a conditioning agent, a softening agent and a stabilizing agent to obtain a mixed solution c, and pumping the mixed solution c into a high-pressure micro-jet extractor for treatment.
Description
Technical Field
The invention relates to the technical field of cosmetics, has an IPC classification number of A61K, and particularly relates to a water-soluble retinol palmitate composition and a preparation method thereof.
Background
The skin is exposed to sunlight for a long time, the skin generates excessive free radicals to cause skin oxidation, the metabolism of the facial skin is slowed down along with the age, the function of fiber collagen of the dermis layer of the skin is degraded, the regulation effect of the skin tension and elasticity is weakened, in addition, the skin aging can be caused by long-term insufficient sleep, irregular diet and excessive smoking and drinking, the proper anti-aging repairing cosmetics are selected to protect and repair cells and recover the activity of skin cells, and the skin wrinkles and dryness caused by the skin oxidation aging are obviously relieved.
Patent CN201811592760.0 discloses an antioxidant and anti-aging whitening essence and a preparation method thereof, the preparation raw materials of the essence comprise a moisturizing agent, a skin repairing agent, an antioxidant, a whitening agent, a skin conditioning agent, an anti-inflammatory agent and the like, and the prepared essence can lighten color spots, prevent pigmentation and prevent skin photoaging, but has poor physicochemical stability.
Patent CN201911396250.0 discloses an anti-aging skin care product and a preparation method thereof, the preparation raw materials of the anti-aging skin care product comprise a moisturizing agent, a preservative, a solubilizer, a thickening agent, a skin conditioner, a chelating agent, an antioxidant and the like, and the prepared skin care product has the functions of maintaining the skin smooth, tender and anti-aging, but the absorption rate of active ingredients is low.
Therefore, the development of the skin care product which has good absorptivity and stable physicochemical property, enhances the skin elasticity, eliminates skin wrinkles and resists skin aging has better practical application value.
Disclosure of Invention
The invention provides a water-soluble retinol palmitate composition, which comprises the following raw materials in percentage by weight: 25-32% of alcohol compound, 20-32% of dispersant, 9-13% of conditioner, 25-30% of softening agent and 0.1-0.3% of stabilizer; the conditioning agent comprises at least retinol palmitate.
Preferably, the alcohol compound includes at least one of 1, 3-propanediol, glycerol, sorbitol, polyethylene glycol 200, and hexanediol.
Further preferably, the alcohol compound is 1, 3-propanediol.
Preferably, the dispersant is at least one or a combination of more of polyglycerol-10 myristate, polysorbate-80, triethanolamine stearate, sodium lauryl sulfate, tween-20 and tween-40.
Further preferably, the dispersing agent is a compound of polyglycerol-10 myristate and polysorbate-80, and the mass ratio of the polyglycerol-10 myristate to the polysorbate-80 is 1-2:0.7-1.7.
Preferably, the conditioning agent comprises at least one or a combination of more of retinol palmitate, tocopherol acetate, hydrogenated lecithin, glutathione peroxidase, papain, superoxide dismutase, metallothionein and ascorbic acid.
Further preferably, the conditioner is a compound of retinol palmitate, tocopherol acetate and hydrogenated lecithin, and the mass ratio of the retinol palmitate to the tocopherol acetate to the hydrogenated lecithin is 9-11:0.8-1.2:0.1-0.3.
Preferably, the emollient is at least one or a combination of caprylic/capric triglyceride, isononyl isononanoate, pyrrolidone carboxylate, isopropyl myristate, butyl stearate and triglyceride.
Further preferably, the emollient is a compound of caprylic/capric triglyceride and isononyl isononanoate, and the mass ratio of the caprylic/capric triglyceride to the isononyl isononanoate is 1.7-2:1.
preferably, the stabilizer comprises at least one of butylated hydroxytoluene, imidazolidinyl urea, methylchloroisothiazolinone, methylisothiazolinone diazolidinyl urea, and sodium hydroxymethylglycinate.
Further preferably, the stabilizer is butylated hydroxytoluene.
In a second aspect, the invention provides a method for preparing a water-soluble retinol palmitate composition, which comprises the following steps:
(1) Placing an alcohol compound in a reaction container, and heating to prepare a mixed solution a for later use;
(2) Adding the dispersing agent, the conditioner, the softening agent and the stabilizer into another reaction container, heating and stirring to obtain a mixed solution b for later use;
(3) Adding the mixed solution b into the mixed solution a, and carrying out shearing emulsification to prepare a mixed solution c;
(4) Pumping the mixed solution c into a high-pressure micro-jet extractor for homogenization treatment, homogenizing by two-stage high-pressure micro-jet with the homogenization interval time of 5-7min, and collecting the mixed solution after all the mixed solution c passes through the extractor to prepare the water-soluble retinol palmitate composition.
Preferably, the preparation method of the water-soluble retinol palmitate composition comprises the following steps:
(1) Placing the alcohol compound in a reaction container, heating to 75-85 ℃ to obtain a mixed solution a for later use;
(2) Adding the dispersing agent, the conditioner, the softening agent and the stabilizer into another reaction vessel, heating and stirring, heating to 75-85 ℃, and stopping stirring to obtain a mixed solution b for later use;
(3) Adding the mixed solution b into the mixed solution a, and carrying out shearing emulsification, wherein the shearing emulsification rate is 15000-25000 rpm, the shearing emulsification time is 8-15 min, and the shearing emulsification temperature is 55-75 ℃ to prepare a mixed solution c;
(4) Pumping the mixed solution c into a high-pressure micro-jet extractor for homogenization treatment, homogenizing by two-stage high-pressure micro-jet with the homogenization interval time of 5-7min, and collecting the mixed solution after all the mixed solution c passes through the extractor to prepare the water-soluble retinol palmitate composition.
Preferably, the first-stage homogenizing flow is 60-120 mL/min, the homogenizing temperature is 40-60 ℃, and the homogenizing pressure is 80-120 MPa.
Preferably, the second-stage homogenizing flow is 90-100 mL/min, the homogenizing temperature is 30-40 ℃, and the homogenizing pressure is 40-70 MPa.
Preferably, the high-pressure micro-jet extractor is a PSI40 type high-pressure micro-jet homogeneous extractor, and the manufacturer is italian PSI corporation.
The third aspect of the invention provides an application of the water-soluble retinol palmitate composition, which is applied to at least one of moisturizing cream, lotion, mask, essence, spray and essence.
Has the beneficial effects that:
(1) According to the invention, the water-soluble retinol palmitate composition is prepared by mixing the alcohol compound, the dispersing agent, the conditioner, the emollient and the stabilizer to obtain a mixed solution c, and pumping the mixed solution c into the high-pressure microjet extractor for treatment, and has the effects of stable physicochemical properties, small particle size, easiness for skin absorption, good skin retention, high absorption rate and small skin irritation, and can effectively increase skin elasticity, eliminate skin wrinkles and recover skin vitality.
(2) The applicant finds that through adding the dispersant which is a compound of polyglycerol-10 myristate and polysorbate-80, the mass ratio of the polyglycerol-10 myristate to the polysorbate-80 is 1-2:0.7-1.7, wherein the conditioner is a compound of retinol palmitate, tocopherol acetate and hydrogenated lecithin, and the mass ratio of the retinol palmitate to the tocopherol acetate to the hydrogenated lecithin is 9-11:0.8-1.2:0.1-0.3, wherein the softening agent is a compound of caprylic acid/capric acid triglyceride and isononyl isononanoate, and the mass ratio of the caprylic acid/capric acid triglyceride to the isononyl isononanoate is 1.7-2: the preparation method comprises the following steps of 1, preparing a water-soluble retinol palmitate composition through a specific shearing emulsification and high-pressure microjet treatment process, wherein the water-soluble retinol palmitate composition has the effects of small particle size, stable physicochemical property, good skin retention, high absorption rate and small skin irritation, can effectively increase skin elasticity, eliminate skin wrinkles and recover skin vitality, active ingredients in a dispersing agent and a softening agent have strong intermolecular force with molecules of a conditioning agent, molecular chains of the dispersing agent and the softening agent are tightly wound and linked through intermolecular interaction to form a stable 'agglomeration' structure, the dispersing agent can optimize a pore structure of the formed structure of the dispersing agent and the conditioning agent, and the active ingredient composition with uniform and stable particle size is formed through the specific shearing emulsification and high-pressure microjet treatment process.
(3) According to the invention, the alcohol compound, the dispersing agent, the conditioner, the emollient and the stabilizer are mixed and stirred to obtain a mixed solution c, and the mixed solution c is pumped into the high-pressure micro-jet extractor for homogenization treatment to prepare the water-soluble retinol palmitate composition, which has the advantages of stable physicochemical property, small particle size of the prepared nano carrier, easiness in skin absorption, good skin retention property, high absorption rate and small skin irritation, and can effectively increase skin elasticity, eliminate skin wrinkles and recover skin vitality.
Detailed Description
Example 1
Example 1 provides a water-soluble retinol palmitate composition, which is prepared from the following raw materials in percentage by weight: 25% of alcohol compound, 20% of dispersant, 9% of conditioner, 25% of softening agent and 0.1% of stabilizer.
The alcohol compound is 1, 3-propylene glycol, and the CAS number of the 1, 3-propylene glycol is 504-63-2.
The dispersing agent is a compound of polyglycerol-10 myristate and polysorbate-80, and the mass ratio of the polyglycerol-10 myristate to the polysorbate-80 is 1:0.7, polyglycerol-10 myristate CAS number 87390-32-7, polysorbate-80, CAS number 9005-65-6.
The conditioner is a compound of retinol palmitate, tocopherol acetate and hydrogenated lecithin, and the mass ratio of the retinol palmitate to the tocopherol acetate to the hydrogenated lecithin is 9:0.8:0.1, retinol palmitate CAS No. 79-81-2, tocopheryl acetate CAS No. 7695-91-2, hydrogenated lecithin CAS No. 92128-87-5.
The softening agent is a compound of caprylic acid/capric acid triglyceride and isononyl isononanoate, and the mass ratio of the caprylic acid/capric acid triglyceride to the isononyl isononanoate is 1.7:1, caprylic/capric triglyceride CAS number 65381-09-1, isononyl isononanoate CAS number 42131-25-9.
The stabilizer is butylated hydroxytoluene, and the CAS number of the butylated hydroxytoluene is 128-37-0.
In a second aspect, the invention provides a method for preparing a water-soluble retinol palmitate composition, which comprises the following steps:
(1) Placing an alcohol compound in a reaction vessel, heating to 75 ℃ to obtain a mixed solution a for later use;
(2) Adding the dispersing agent, the conditioner, the softening agent and the stabilizer into another reaction vessel, heating and stirring, heating to 75 ℃, and stopping stirring to obtain a mixed solution b for later use;
(3) Adding the mixed solution b into the mixed solution a, and carrying out shearing emulsification at the shearing emulsification rate of 15000rpm for 8min at the shearing emulsification temperature of 55 ℃ to prepare a mixed solution c;
(4) Pumping the mixed solution c into a high-pressure micro-jet extractor for homogenization treatment, carrying out two-stage high-pressure micro-jet homogenization, wherein the homogenization interval time is 5min, and collecting the mixed solution after all the mixed solution c passes through the extractor to prepare the water-soluble retinol palmitate composition.
The first-stage homogenizing flow is 60mL/min, the homogenizing temperature is 40 ℃, and the homogenizing pressure is 80MPa.
The second-stage homogenizing flow is 90mL/min, the homogenizing temperature is 30 ℃, and the homogenizing pressure is 40MPa.
The high-pressure micro-jet extractor is a PSI40 type high-pressure micro-jet homogenizing extractor, and the manufacturer is Italian PSI company.
The third aspect of the invention provides application of the water-soluble retinol palmitate composition in the essential water.
Example 2
Example 2 provides a water-soluble retinol palmitate composition, which is prepared from the following raw materials in percentage by weight: 30% of alcohol compound, 30% of dispersant, 11.2% of conditioner, 28.6% of emollient and 0.2% of stabilizer.
The alcohol compound is 1, 3-propylene glycol, and the CAS number of the 1, 3-propylene glycol is 504-63-2.
The dispersing agent is a compound of polyglycerol-10 myristate and polysorbate-80, and the mass ratio of the polyglycerol-10 myristate to the polysorbate-80 is 1:1, polyglycerol-10 myristate CAS number 87390-32-7, polysorbate-80, CAS number 9005-65-6.
The conditioner is a compound of retinol palmitate, tocopherol acetate and hydrogenated lecithin, and the mass ratio of the retinol palmitate to the tocopherol acetate to the hydrogenated lecithin is 10:1:0.2, retinol palmitate CAS No. 79-81-2, tocopheryl acetate CAS No. 7695-91-2, hydrogenated lecithin CAS No. 92128-87-5.
The softening agent is a compound of caprylic acid/capric acid triglyceride and isononyl isononanoate, and the mass ratio of the caprylic acid/capric acid triglyceride to the isononyl isononanoate is 1.9:1, caprylic/capric triglyceride CAS number 65381-09-1, isononyl isononanoate CAS number 42131-25-9.
The stabilizer is butylated hydroxytoluene, and the CAS number of the butylated hydroxytoluene is 128-37-0.
In a second aspect, the invention provides a method for preparing a water-soluble retinol palmitate composition, which comprises the following steps:
(1) Placing the alcohol compound in a reaction vessel, heating to 80 ℃ to obtain a mixed solution a for later use;
(2) Adding the dispersing agent, the conditioner, the softening agent and the stabilizer into another reaction vessel, heating and stirring, heating to 80 ℃, and stopping stirring to obtain a mixed solution b for later use;
(3) Adding the mixed solution b into the mixed solution a, and carrying out shear emulsification, wherein the shear emulsification rate is 20000rpm, the shear emulsification time is 10min, and the shear emulsification temperature is 60 ℃ to prepare a mixed solution c;
(4) Pumping the mixed solution c into a high-pressure microjet extractor for homogenization treatment, homogenizing by two-stage high-pressure microjet with the homogenization interval time of 6min, and collecting the mixed solution after all the mixed solution c passes through the extractor to prepare the water-soluble retinol palmitate composition.
The first-stage homogenizing flow is 100mL/min, the homogenizing temperature is 50 ℃, and the homogenizing pressure is 100MPa.
The second-stage homogenizing flow is 95mL/min, the homogenizing temperature is 35 ℃, and the homogenizing pressure is 60MPa.
The high-pressure micro-jet extractor is a PSI40 type high-pressure micro-jet homogenizing extractor, and the manufacturer is Italian PSI company.
The third aspect of the invention provides application of the water-soluble retinol palmitate composition in the essential water.
Comparative example 1
The specific implementation manner is the same as that of example 2, except that the dispersing agent is a compound of polyglycerol-10 myristate and polysorbate-80, and the mass ratio of the polyglycerol-10 myristate to the polysorbate-80 is 0.2:0.7, polyglycerol-10 myristate CAS number 87390-32-7, polysorbate-80, CAS number 9005-65-6.
Comparative example 2
The specific implementation manner is the same as that in example 2, except that the conditioner is a compound of retinol palmitate, tocopherol acetate and hydrogenated lecithin, and the mass ratio of the retinol palmitate, the tocopherol acetate and the hydrogenated lecithin is 1:0.3:0.1, retinol palmitate CAS No. 79-81-2, tocopheryl acetate CAS No. 7695-91-2, hydrogenated lecithin CAS No. 92128-87-5.
Comparative example 3
The specific implementation manner is the same as that in example 2, except that the emollient is a compound of caprylic/capric triglyceride and isononyl isononanoate, and the mass ratio of the caprylic/capric triglyceride to the isononyl isononanoate is 0.2:1, acid/capric acid triglyceride CAS number 65381-09-1, isononyl isononanoate CAS number 42131-25-9.
And (3) performance testing:
the appearance, the amount of toxic substances and the microbiological indicators of a water-soluble retinol palmitate composition prepared according to examples 1-2 and comparative examples 1-3 were tested according to standard QB/T2660-2004 lotion.
The pH of one of the water-soluble retinol palmitate compositions prepared in examples 1-2, comparative examples 1-3 was tested according to the standard GB/t13531.1.2008, general test methods for cosmetics.
The particle size of a water-soluble retinol palmitate composition prepared in each of examples 1-2 and comparative examples 1-3 was measured using LS-909 type laser particle sizer.
The water-soluble retinol palmitate compositions prepared in examples 1-2 and comparative examples 1-3 were placed at the temperature of (40 + -1) deg.C and (5 + -1) deg.C for 24h, and the water-soluble retinol palmitate compositions prepared in examples 1-2 and comparative examples 1-3 were not delaminated.
TABLE 1 Performance test results
Claims (10)
1. The water-soluble retinol palmitate composition is characterized in that the preparation raw materials comprise the following components in percentage by weight: 25-32% of alcohol compound, 20-32% of dispersant, 9-13% of conditioner, 25-30% of softening agent and 0.1-0.3% of stabilizer;
the conditioning agent comprises at least retinol palmitate.
2. The composition of claim 1, wherein the alcohol compound comprises at least one of 1, 3-propanediol, glycerol, sorbitol, polyethylene glycol 200, and hexanediol.
3. The water-soluble retinol palmitate composition as claimed in claim 1 or 2, wherein the dispersant is at least one or more of polyglyceryl-10 myristate, polysorbate-80, triethanolamine stearate, sodium lauryl sulfate, tween-20 and tween-40.
4. The water-soluble retinol palmitate composition as claimed in claim 3, wherein the dispersing agent is a mixture of polyglycerol-10 myristate and polysorbate-80, the mass ratio of polyglycerol-10 myristate to polysorbate-80 is 1-2:0.7-1.7.
5. The water-soluble retinol palmitate composition as claimed in any one of claims 1 to 4, wherein said conditioning agent is a combination of retinol palmitate, tocopherol acetate and hydrogenated lecithin, and the mass ratio of retinol palmitate, tocopherol acetate and hydrogenated lecithin is 9-11:0.8-1.2:0.1-0.3.
6. The composition of claim 1, wherein the emollient is at least one or a combination of caprylic/capric triglyceride, isononyl isononanoate, pyrrolidone carboxylate, isopropyl myristate, butyl stearate, and triglyceride.
7. The water-soluble retinol palmitate composition as claimed in claim 6, wherein the emollient is a combination of caprylic/capric triglyceride and isononyl isononanoate, and the mass ratio of caprylic/capric triglyceride to isononyl isononanoate is 1.7-2:1.
8. the composition of claim 1, wherein the stabilizer comprises at least one of butylated hydroxytoluene, imidazolidinyl urea, methylchloroisothiazolinone, methylisothiazolinone diazolidinyl urea, and sodium hydroxymethylglycinate.
9. Use of a water-soluble retinol palmitate composition according to any of claims 1-8 in a skin care product;
the skin care product comprises at least one of moisturizing cream, lotion, facial mask, essence, spray and essence water.
10. A method of preparing a water soluble retinol palmitate composition as claimed in any of claims 1-8, comprising the steps of:
(1) Placing an alcohol compound in a reaction container, and heating to prepare a mixed solution a for later use;
(2) Adding the dispersing agent, the conditioner, the softening agent and the stabilizer into another reaction container, heating and stirring to obtain a mixed solution b for later use;
(3) Adding the mixed solution b into the mixed solution a, and performing shearing emulsification to prepare a mixed solution c;
(4) Pumping the mixed solution c into a high-pressure micro-jet extractor for homogenization treatment, homogenizing by two-stage high-pressure micro-jet with the homogenization interval time of 5-7min, and collecting the mixed solution after all the mixed solution c passes through the extractor to prepare the water-soluble retinol palmitate composition.
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| Publication number | Priority date | Publication date | Assignee | Title |
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| WO1998050005A1 (en) * | 1997-05-09 | 1998-11-12 | Medlogic Global Corporation | Compositions for cosmetic applications |
| KR20110114068A (en) * | 2010-04-12 | 2011-10-19 | 주식회사 미산 | Vitamin complex, preparation methods and cosmetic composition comprising thereof |
| CN109453043A (en) * | 2018-12-13 | 2019-03-12 | 诺斯贝尔化妆品股份有限公司 | A kind of nanoemulsions having good stability |
| CN110623858A (en) * | 2019-08-28 | 2019-12-31 | 上海克琴科技有限公司 | Preparation method and application of vitamin A nano inclusion |
| WO2021017846A1 (en) * | 2019-07-30 | 2021-02-04 | 浙江养生堂天然药物研究所有限公司 | Enhanced anti-aging cosmetic composition |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1998050005A1 (en) * | 1997-05-09 | 1998-11-12 | Medlogic Global Corporation | Compositions for cosmetic applications |
| KR20110114068A (en) * | 2010-04-12 | 2011-10-19 | 주식회사 미산 | Vitamin complex, preparation methods and cosmetic composition comprising thereof |
| CN109453043A (en) * | 2018-12-13 | 2019-03-12 | 诺斯贝尔化妆品股份有限公司 | A kind of nanoemulsions having good stability |
| WO2021017846A1 (en) * | 2019-07-30 | 2021-02-04 | 浙江养生堂天然药物研究所有限公司 | Enhanced anti-aging cosmetic composition |
| CN110623858A (en) * | 2019-08-28 | 2019-12-31 | 上海克琴科技有限公司 | Preparation method and application of vitamin A nano inclusion |
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