CN113827497A

CN113827497A - Skin anti-aging formula and preparation method thereof

Info

Publication number: CN113827497A
Application number: CN202111259798.8A
Authority: CN
Inventors: 赵洪敬
Original assignee: Suzhou Jiuwei Anti Aging Technology Research Institute
Current assignee: Suzhou Jiuwei Anti Aging Technology Research Institute
Priority date: 2021-10-28
Filing date: 2021-10-28
Publication date: 2021-12-24

Abstract

The invention is suitable for the technical field of skin anti-aging, and provides a skin anti-aging formula and a preparation method thereof, wherein hydrolyzed collagen, polypeptide, a humectant, compound amino acid, ceramide-3, polyalcohol and an antioxidant are scientifically proportioned, and the skin anti-aging agent can remove wrinkles instantly and permanently, and rebuild a skin cell collagen network after long-term use; the anti-aging transdermal polypeptide preparation contains various anti-aging components, can effectively keep the anti-aging effect, and the liposome nano preparation reduces the possibility of hydrolysis in the using process; the collagen and the tripeptide collagen can be fully absorbed by the human body, and meanwhile, the tripeptide collagen can also effectively permeate into cells of stratum corneum, dermis and hair root, so that the effects of moisturizing, nourishing, skin-building, skin-tightening, repairing and the like are achieved.

Description

Skin anti-aging formula and preparation method thereof

Technical Field

The invention belongs to the technical field of skin anti-aging, and particularly relates to a skin anti-aging formula and a preparation method thereof.

Background

The skin is connective tissue, and consists of three parts, namely epidermis, dermis and subcutaneous tissue from outside to inside. The dermis is a reticular structure composed of collagen, elastin, hyaluronic acid, microvasculature and other substances, wherein the collagen and elastin play a supporting role, so that the dermis has good firmness and elasticity. Sodium hyaluronate can be used as moisturizing factor to retain moisture in skin. According to scientific research, the speed of generating sodium hyaluronate and collagen in vivo is reduced from 20 years old, and the elasticity of elastin capable of rapidly rebounding skin is reduced, so that the substances in the skin are lost year by year, the content is reduced to half by 40 years old, skin tissues are shrunk, gaps are formed, and the skin shows aging phenomena such as looseness, wrinkles, dryness, roughness, large pores and the like. But the change of the skin is not only simple as the increase of the age, but also is a result of the common influence of multiple factors such as age, heredity, insufficient sleep, diet, solar radiation, dust, environmental pollution, psychological stress and the like. The damage of the free radicals generated in the environment to the skin is also an important factor.

Disclosure of Invention

The invention provides a skin anti-aging formula and a preparation method thereof, and aims to solve the problems in the background art.

The skin anti-aging formula comprises, by mass, 3-10% of hydrolyzed collagen, 3-15% of a polypeptide preparation, 0.4-10% of a humectant, 1-3% of compound amino acid, 30.5-1% of ceramide, 3-10% of polyhydric alcohol, 1-10% of an antioxidant, 0.1-1% of a preservative, 0.02-0.1% of a chelating agent, 0.1-5% of an anti-allergic agent, 0.5-1% of a diluent, 2-9% of liquid protein, 0.2-1% of a sodium chloride diluent, 1-5% of a DNA fructose polypeptide compound factor, 2-10% of tripeptide collagen and the balance deionized water.

Preferably, the first diluent consists of collagen, mannitol and sodium chloride.

Preferably, the polypeptide preparation comprises 1-50% of hydroxypropyl tetrahydropyrane triol, 0.1-5% of collagen peptide, 0.1-1.0% of adenosine, 0.1-0.5% of carnosine, 0.5-5.0% of transdermal peptide, 0.4-0.8% of p-hydroxyacetophenone and the balance of water.

Preferably, the relative molecular weight of the hydrolyzed collagen is 5000-;

the humectant is at least one of sodium hyaluronate, sodium polyglutamate, betaine and trehalose;

the compound amino acid is at least one of serine, alanine, aspartic acid, glutamic acid, proline, isoleucine, arginine, leucine, lactic acid, sodium lactate and glycine;

the polyalcohol is at least one of glycerol, pentanediol, 1, 2-pentanediol, 1, 3-butanediol, 1, 2-hexanediol, 1, 2-propanediol, 1, 3-propanediol, dipropylene glycol and methyl propanediol;

the antioxidant is at least one of vitamin c ethyl ether, water-soluble fullerene, flavonoid, coenzyme Q10, astaxanthin, plant polyphenol or L-carnosine;

the preservative is at least one of methyl paraben, phenoxyethanol and ethylhexyl glycerin;

the chelating agent is EDTA-disodium;

the anti-sensitivity agent is: at least one of allantoin, dipotassium glycyrrhizinate, aloe extract, honey extract, green tea extract, purslane extract, scutellaria extract and cactus extract.

A method for preparing an anti-aging skin formula comprises the following steps:

the method comprises the following steps: selecting and preparing raw materials;

step two: preparing a first composition, wherein the first composition comprises hydrolyzed collagen, a polypeptide preparation, a humectant, compound amino acid, ceramide-3, polyalcohol, an antioxidant, a preservative, a chelating agent and an anti-allergy agent;

step three: adding diluent I, liquid protein, sodium chloride diluent, DNA fructose polypeptide complex factor and tripeptide collagen, and mixing.

Preferably, in step one, the preparation of the polypeptide preparation comprises the following steps:

uniformly mixing hydroxypropyl tetrahydropyrane triol, collagen peptide and deionized water to prepare a hydroxypropyl tetrahydropyrane triol mixed solution;

mixing emulsifier, glycerol and oil in proportion, and stirring to obtain lecithin mixed solution; adding adenosine, carnosine, transdermal peptide and p-hydroxyacetophenone into the hydroxypropyl tetrahydropyrane triol mixed solution according to a ratio, and uniformly mixing to obtain a polypeptide mixed solution;

and adding the polypeptide mixed solution into the lecithin mixed solution, and performing two-stage high-pressure shearing homogenization to obtain the anti-aging transdermal polypeptide preparation.

Preferably, in the step one, the compound amino acid is preferably a mixture of serine and alanine;

the polyol is preferably a mixture of glycerol and pentanediol;

the flavonoid compound is extracted from the root of Hemsleya amabilis;

the plant polyphenol is at least one of anthocyanin, catechin and gallic acid.

Preferably, in the second step, the hydrolyzed collagen, the polypeptide preparation, the humectant, the complex amino acid, the ceramide-3, the polyol, the antioxidant, the preservative, the chelating agent, and the anti-allergic agent are added and mixed in this order.

Preferably, in the third step, the diluent I, the liquid protein, the sodium chloride diluent, the DNA fructose polypeptide complex factor and the tripeptide collagen are sequentially added according to the corresponding proportion and mixed to prepare the collagen peptide.

Compared with the prior art, the invention has the beneficial effects that: the invention relates to a skin anti-aging formula and a preparation method thereof, wherein the formula comprises the following components: on one hand, the hydrolyzed collagen, the polypeptide, the humectant, the compound amino acid, the ceramide-3, the polyalcohol and the antioxidant are scientifically proportioned, so that wrinkles can be removed instantly and durably, and the skin-care cream has the effects of reconstructing a skin cell collagen network, deeply removing wrinkles, resisting aging, plumping the skin, improving the water content of epidermal cells, enhancing the skin barrier function, brightening and increasing the skin elasticity and the skin color after long-term use; on the other hand, the anti-aging transdermal polypeptide preparation provided by the application contains various anti-aging components, hydroxypropyl tetrahydropyrane triol can effectively promote the regeneration of aging collagen, so that cells are full, the regeneration of the collagen in the skin can be stabilized, adenosine can stimulate the renewal of fibroblasts, carnosine can effectively prevent glycosylation, lipid oxidation caused by free radicals and metal ions can be inhibited, a light aging resistant barrier of the skin can be constructed, the transdermal peptide can help the skin to improve the absorption rate of hydroxypropyl tetrahydropyrane triol, the absorption rate of the anti-aging components of the skin is improved, the carnosine can help the regenerated collagen to increase the skin resistance, the activity of the new cells under the condition of the free radicals is kept, the anti-aging effect can be effectively kept, and in the preparation process of the anti-aging transdermal polypeptide preparation, due to the two-stage high-pressure shearing microjet homogenization, the hydroxypropyl tetrahydropyrane triol and the squalane form small droplets with the particle size of less than 50nm under the action of the lecithin, so that the small droplets can reach the basal layer of the skin more easily, the absorption rate is improved, and the anti-aging transdermal polypeptide preparation is a liposome nano preparation, so that the possibility of being hydrolyzed in the using process is reduced, and the anti-aging effect is improved.

The key point is that the collagen and the tripeptide collagen can be fully absorbed by the human body, and meanwhile, the tripeptide collagen can also effectively permeate into cells of the cuticle, the dermis and the hair root, so that the effects of moisturizing, nourishing, skin-building, skin-tightening, wrinkle prevention, repair and the like are achieved.

Drawings

FIG. 1 is a schematic diagram of the steps of the present invention.

Detailed Description

In order to make the objects, technical solutions and advantages of the present invention more apparent, the present invention is described in further detail below with reference to the accompanying drawings and embodiments. It should be understood that the specific embodiments described herein are merely illustrative of the invention and are not intended to limit the invention.

Referring to fig. 1, the present invention provides a technical solution:

a skin anti-aging formula and a preparation method thereof comprise, by mass, 3-10% of hydrolyzed collagen, 3-15% of a polypeptide preparation, 0.4-10% of a humectant, 1-3% of compound amino acid, 30.5-1% of ceramide, 3-10% of polyhydric alcohol, 1-10% of an antioxidant, 0.1-1% of a preservative, 0.02-0.1% of a chelating agent, 0.1-5% of an anti-allergic agent, 0.5-1% of a diluent I, 2-9% of liquid protein, 0.2-1% of a sodium chloride diluent, 1-5% of a DNA fructose polypeptide compound factor, 2-10% of tripeptide collagen, and the balance of deionized water. Wherein, the first diluent consists of collagen, mannitol and sodium chloride.

The polypeptide preparation comprises 1-50% of hydroxypropyl tetrahydropyrane triol, 0.1-5% of collagen peptide, 0.1-1.0% of adenosine, 0.1-0.5% of carnosine, 0.5-5.0% of transdermal peptide, 0.4-0.8% of p-hydroxyacetophenone and the balance of water.

The preparation of the polypeptide preparation comprises the following steps:

and adding the polypeptide mixed solution into the lecithin mixed solution, and performing two-stage high-pressure shearing and homogenization to obtain the anti-aging transdermal polypeptide preparation.

the relative molecular weight of hydrolyzed collagen is 5000-. The selected micromolecule hydrolyzed collagen can quickly permeate into the horny layer and other epidermal layers, so that the effects of quickly supplementing collagen, plumping skin and increasing skin elasticity are achieved, and the effect of immediately removing wrinkles is achieved.

The humectant is at least one of sodium hyaluronate, sodium polyglutamate, betaine, and trehalose. The relative molecular weight of sodium hyaluronate is 8000-10000 kD. The small-molecule sodium hyaluronate is selected to improve the permeability of the stratum corneum, improve the water content of the stratum corneum and improve the dark appearance of the skin, and compared with the large-molecule sodium hyaluronate, the small-molecule sodium hyaluronate can go deeper into the skin and accelerate the water replenishing and moisturizing effects of the skin.

The compound amino acid is at least one of serine, alanine, aspartic acid, glutamic acid, proline, isoleucine, arginine, leucine, lactic acid, sodium lactate and glycine. The compound amino acid is a mixture of serine and alanine.

The polyalcohol is at least one of glycerol, pentanediol, 1, 2-pentanediol, 1, 3-butanediol, 1, 2-hexanediol, 1, 2-propanediol, 1, 3-propanediol, dipropylene glycol, and methyl propanediol. The polyol is a mixture of glycerol and pentanediol.

The antioxidant is at least one of vitamin C ethyl ether, water-soluble fullerene, flavonoid, coenzyme Q10, astaxanthin, plant polyphenol or L-carnosine. The flavonoids are extracted from rhizoma Polygoni Cuspidati. The plant polyphenol is at least one of anthocyanidin, catechin, and gallic acid. The antioxidant is a mixture of flavonoids and plant polyphenol, and the mass ratio of the flavonoids to the plant polyphenol is 1: 1. The flavonoid compound and the plant polyphenol are compounded, so that the anti-aging effect of the composition can be improved while the oxidation resistance is realized. The vitamin C ethyl ether is a very useful vitamin C derivative, is not only a vitamin C derivative which is very stable on chemical substances and is not discolored, but also an oleophylic and hydrophilic amphoteric substance, and greatly expands the application range of the vitamin C ethyl ether, especially the application in daily chemicals. The 3-O-ethyl ascorbyl ether can easily pass through the horny layer to enter the dermis layer, the 3-O-ethyl ascorbyl ether can be easily decomposed by biological enzymes in a body after entering the body so as to exert the biological effect of vitamin C, and the VC ethyl ether can directly participate in the synthesis of collagen after entering the dermis layer so as to repair the activity of skin cells and increase the collagen, so that the skin becomes full and elastic, and the skin is fine and smooth. Fullerenes are a class of substances composed of carbon elements, present in a spherical, ellipsoidal, or tubular structure, which are called "radical-absorbing sponges", and are not themselves easily consumed in scavenging radicals. Due to the hollow cage structure of the fullerene, the fullerene has special physical and chemical properties such as catalytic activity, carrier effect, biological activity and the like, and has the effects of resisting free radicals, resisting oxidation, lightening spots, whitening, inhibiting inflammation and the like in the aspect of cosmetics. In addition, the compound also has obvious inhibition effect on MMPs, and can protect extracellular matrixes such as collagen, elastin, laminin and the like from being degraded. The invention adopts water-soluble fullerene, can promote the absorption of hydrolyzed collagen and polypeptide, and simultaneously improves the effects of moisturizing and delaying senility. The flavonoid compounds have the effects of resisting free radicals and oxidation: researches show that the flavonoid compound has the capability of improving the oxidation resistance and the free radical removal capability of animal organisms. The hydrogen atom on the phenolic hydroxyl group of the flavonoid compound can be combined with peroxy radical to generate flavone free radical, and then the flavone free radical reacts with other free radicals, so that the free radical chain reaction is stopped. The ortho-position phenolic hydroxyl in the phenolic hydroxyl structure (catechol or pyrogallol) of the plant polyphenol is easily oxidized into quinone structure, consumes oxygen in the environment, and has strong capture capacity on free radicals such as active oxygen, so that the polyphenol has strong oxidation resistance and free radical scavenging capacity. Astaxanthin is a chain-breaking antioxidant. Has strong oxidation resistance, can eliminate nitrogen dioxide, sulfide, disulfide and the like, can reduce lipid peroxidation, and effectively inhibit lipid peroxidation caused by free radicals. L-carnosine has a strong antioxidant capacity and has been shown to scavenge the reactive oxygen radicals and unsaturated aldehydes formed by the excessive oxidation of fatty acids in cell membranes during oxidative stress.

The antiseptic is at least one of methyl paraben, phenoxyethanol and ethylhexyl glycerin.

The chelating agent is EDTA-disodium.

The anti-allergic agent is: at least one of allantoin, dipotassium glycyrrhizinate, aloe extract, honey extract, green tea extract, purslane extract, scutellaria extract and cactus extract. The anti-aging and wrinkle-removing effect of the composition can be improved by adding the anti-allergy agent, and particularly, the wrinkle-removing effect of the composition can be accelerated by combining and compounding the honey extract and the green tea extract.

Step two: preparing a first composition, wherein the first composition comprises hydrolyzed collagen, a polypeptide preparation, a humectant, compound amino acid, ceramide-3, polyalcohol, an antioxidant, a preservative, a chelating agent and an anti-allergy agent.

In the second step, the reagents are added and mixed according to the sequence of the hydrolyzed collagen, the polypeptide preparation, the humectant, the compound amino acid, the ceramide-3, the polyalcohol, the antioxidant, the preservative, the chelating agent and the anti-allergic agent.

In the third step, the diluent I, the liquid protein, the sodium chloride diluent, the DNA fructose polypeptide complex factor and the tripeptide collagen are sequentially added according to the corresponding proportion and mixed to prepare the composition.

The above description is only for the purpose of illustrating the preferred embodiments of the present invention and is not to be construed as limiting the invention, and any modifications, equivalents and improvements made within the spirit and principle of the present invention are intended to be included within the scope of the present invention.

Claims

1. A skin anti-aging formula and a preparation method thereof, which is characterized in that: the collagen protein hydrolysate comprises, by mass, 3-10% of hydrolyzed collagen, 3-15% of a polypeptide preparation, 0.4-10% of a humectant, 1-3% of compound amino acid, 30.5-1% of ceramide, 3-10% of polyhydric alcohol, 1-10% of an antioxidant, 0.1-1% of a preservative, 0.02-0.1% of a chelating agent, 0.1-5% of an anti-allergic agent, 0.5-1% of a diluent, 2-9% of liquid protein, 0.2-1% of a sodium chloride diluent, 1-5% of a DNA fructose polypeptide complex factor, 2-10% of tripeptide collagen and the balance deionized water.

2. The skin antiaging formulation according to claim 1, wherein: wherein, the first diluent consists of collagen, mannitol and sodium chloride.

3. The skin antiaging formulation according to claim 1, wherein: the polypeptide preparation comprises 1-50% of hydroxypropyl tetrahydropyrane triol, 0.1-5% of collagen peptide, 0.1-1.0% of adenosine, 0.1-0.5% of carnosine, 0.5-5.0% of transdermal peptide, 0.4-0.8% of p-hydroxyacetophenone and the balance of water.

4. The skin antiaging formulation according to claim 1, wherein: the relative molecular weight of the hydrolyzed collagen is 5000-;

the chelating agent is EDTA-disodium;

5. A method of preparing an anti-aging skin formulation as claimed in any one of claims 1 to 4, wherein: the method comprises the following steps:

step two: preparing a first composition: wherein the collagen protein hydrolysate, the polypeptide preparation, the humectant, the compound amino acid, the ceramide-3, the polyalcohol, the antioxidant, the preservative, the chelating agent and the anti-allergy agent are included;

step three: preparing an anti-aging agent for skin: adding diluent I, liquid protein, sodium chloride diluent, DNA fructose polypeptide complex factor and tripeptide collagen, and mixing.

6. The method of preparing a skin anti-aging formulation according to claim 5, wherein: in step one, the preparation of the polypeptide preparation comprises the following steps:

7. The method of preparing a skin anti-aging formulation according to claim 5, wherein: in step one, the compound amino acid is preferably a mixture of serine and alanine;

the polyol is preferably a mixture of glycerol and pentanediol;

the flavonoid compound is extracted from the root of Hemsleya amabilis;

the plant polyphenol is at least one of anthocyanin, catechin and gallic acid.

8. The method of preparing a skin anti-aging formulation according to claim 5, wherein: in the second step, the reagents are added and mixed according to the sequence of the hydrolyzed collagen, the polypeptide preparation, the humectant, the compound amino acid, the ceramide-3, the polyalcohol, the antioxidant, the preservative, the chelating agent and the anti-allergic agent.

9. The method of preparing a skin anti-aging formulation according to claim 5, wherein: in the third step, the diluent I, the liquid protein, the sodium chloride diluent, the DNA fructose polypeptide complex factor and the tripeptide collagen are sequentially added according to the corresponding proportion and mixed to prepare the composition.