CN1157818A - 1α，26-二羟基-D-高维生素D3 - Google Patents

1α，26-二羟基-D-高维生素D3 Download PDF

Info

Publication number
CN1157818A
CN1157818A CN96122882A CN96122882A CN1157818A CN 1157818 A CN1157818 A CN 1157818A CN 96122882 A CN96122882 A CN 96122882A CN 96122882 A CN96122882 A CN 96122882A CN 1157818 A CN1157818 A CN 1157818A
Authority
CN
China
Prior art keywords
compound
gram
milliliters
methyl
naphthalene
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CN96122882A
Other languages
English (en)
Chinese (zh)
Inventor
F·施钠德
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
F Hoffmann La Roche AG
Original Assignee
F Hoffmann La Roche AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by F Hoffmann La Roche AG filed Critical F Hoffmann La Roche AG
Publication of CN1157818A publication Critical patent/CN1157818A/zh
Pending legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C401/00—Irradiation products of cholesterol or its derivatives; Vitamin D derivatives, 9,10-seco cyclopenta[a]phenanthrene or analogues obtained by chemical preparation without irradiation
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

Landscapes

  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Engineering & Computer Science (AREA)
  • Rheumatology (AREA)
  • Dermatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
CN96122882A 1995-10-30 1996-10-28 1α，26-二羟基-D-高维生素D3 Pending CN1157818A (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP95117037.2 1995-10-30
EP95117037 1995-10-30

Publications (1)

Publication Number Publication Date
CN1157818A true CN1157818A (zh) 1997-08-27

Family

ID=8219763

Family Applications (1)

Application Number Title Priority Date Filing Date
CN96122882A Pending CN1157818A (zh) 1995-10-30 1996-10-28 1α，26-二羟基-D-高维生素D3

Country Status (15)

Country Link
US (1) US5905074A (xx)
EP (1) EP0771789B1 (xx)
JP (1) JP3059108B2 (xx)
CN (1) CN1157818A (xx)
AR (1) AR004700A1 (xx)
AT (1) ATE189812T1 (xx)
BR (1) BR9605354A (xx)
CA (1) CA2188634A1 (xx)
DE (1) DE69606680T2 (xx)
DK (1) DK0771789T3 (xx)
ES (1) ES2144183T3 (xx)
GR (1) GR3033254T3 (xx)
MX (1) MX9605206A (xx)
PT (1) PT771789E (xx)
TR (1) TR199600849A2 (xx)

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN100349573C (zh) * 2002-09-18 2007-11-21 骨疗国际公司 用于亲脂性药物的制剂
CN100421667C (zh) * 2002-04-19 2008-10-01 骨疗国际公司 活性维生素d化合物在制备用于治疗和预防甲状旁腺机能亢进的药物中的应用
CN105348163A (zh) * 2014-08-18 2016-02-24 武汉启瑞药业有限公司 维生素d类似物及其制备方法和医药用途

Families Citing this family (27)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5763429A (en) * 1993-09-10 1998-06-09 Bone Care International, Inc. Method of treating prostatic diseases using active vitamin D analogues
US6242434B1 (en) * 1997-08-08 2001-06-05 Bone Care International, Inc. 24-hydroxyvitamin D, analogs and uses thereof
US6566353B2 (en) * 1996-12-30 2003-05-20 Bone Care International, Inc. Method of treating malignancy associated hypercalcemia using active vitamin D analogues
US20020128240A1 (en) * 1996-12-30 2002-09-12 Bone Care International, Inc. Treatment of hyperproliferative diseases using active vitamin D analogues
US5965734A (en) * 1997-01-31 1999-10-12 Celgene Corporation Processes and intermediates for preparing 2-substituted piperidine stereoisomers
US20030129194A1 (en) * 1997-02-13 2003-07-10 Bone Care International, Inc. Targeted therapeutic delivery of vitamin D compounds
AU8860298A (en) * 1997-07-17 1999-02-10 F. Hoffmann-La Roche Ag Dihomo-seco-cholestanes with two unsaturated bones in the side chain
US6087350A (en) * 1997-08-29 2000-07-11 University Of Pittsburgh Of The Commonwealth System Of Higher Education Use of pretreatment chemicals to enhance efficacy of cytotoxic agents
US5919986A (en) * 1997-10-17 1999-07-06 Hoffmann-La Roche Inc. D-homo vitamin D3 derivatives
ES2368824T3 (es) * 1998-03-27 2011-11-22 Oregon Health & Science University Vitamina d y sus análogos en el tratamiento de tumores y otros desórdenes hiperproliferativos.
EP1219599B1 (en) * 1999-08-27 2010-03-31 Hiroaki Takayama Vitamin d derivatives having substituents at the 2 alpha-position
US6989377B2 (en) 1999-12-21 2006-01-24 Wisconsin Alumni Research Foundation Treating vitamin D responsive diseases
US6358939B1 (en) 1999-12-21 2002-03-19 Northern Lights Pharmaceuticals, Llc Use of biologically active vitamin D compounds for the prevention and treatment of inflammatory bowel disease
IL153378A0 (en) * 2000-07-18 2003-07-06 Bone Care Internat Inc STABILIZED 1alpha-HYDROXY VITAMIN D
BR0214679A (pt) * 2001-12-03 2004-12-14 Novacea Inc Composições farmacêuticas compreendendo compostos a base de vitamina d ativa
AU2002360015A1 (en) * 2001-12-26 2003-07-15 Chugai Seiyaku Kabushiki Kaisha 2-substituted vitamin d derivatives
US20050026877A1 (en) * 2002-12-03 2005-02-03 Novacea, Inc. Pharmaceutical compositions comprising active vitamin D compounds
BRPI0407104A (pt) * 2003-01-30 2006-01-24 Teijin Pharma Ltd Composto, agente terapêutico, composição farmacêutica, e, processo para sintetizar um composto
US20050020546A1 (en) * 2003-06-11 2005-01-27 Novacea, Inc. Pharmaceutical compositions comprising active vitamin D compounds
US20060189586A1 (en) * 2003-06-11 2006-08-24 Cleland Jeffrey L Pharmaceutical compositions comprising active vitamin D compounds
US20060003950A1 (en) * 2004-06-30 2006-01-05 Bone Care International, Inc. Method of treating prostatic diseases using a combination of vitamin D analogues and other agents
US7094775B2 (en) * 2004-06-30 2006-08-22 Bone Care International, Llc Method of treating breast cancer using a combination of vitamin D analogues and other agents
NZ555279A (en) * 2004-11-22 2010-12-24 Wisconsin Alumni Res Found 2alpha-methyl-19-nor-1alpha-hydroxy-homopregnacalciferol and its uses
JP4719284B2 (ja) 2008-10-10 2011-07-06 トヨタ自動車株式会社 表面検査装置
CA2981549A1 (en) * 2009-01-27 2010-08-05 Berg Llc Vitamin d3 and analogs thereof for alleviating side effects associated with chemotherapy
SG10201404883YA (en) 2009-08-14 2014-10-30 Berg Llc Vitamin d3 and analogs thereof for treating alopecia
AU2014274099A1 (en) 2013-05-29 2015-12-24 Berg Llc Preventing or mitigating chemotherapy induced alopecia using vitamin D

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3697559A (en) * 1971-02-25 1972-10-10 Wisconsin Alumni Res Found 1,25-dihydroxycholecalciferol
US4410515A (en) * 1981-04-01 1983-10-18 Massachusetts General Hospital Vitamin D glycosides and a method of use
US4595776A (en) * 1983-03-21 1986-06-17 Hoffmann-La Roche Inc. Synthesis of 1α,25-dihydroxyergocalciferol
US4521410A (en) * 1984-05-03 1985-06-04 The General Hospital Corporation Vitamin D glycosyl orthoesters
AU666563B2 (en) * 1992-08-07 1996-02-15 Wisconsin Alumni Research Foundation Preparation of 19-nor-vitamin D compounds
EP0972762B1 (en) * 1993-07-09 2003-10-01 Laboratoire Theramex Novel structural analogues of vitamin D
FR2709126B1 (fr) * 1993-08-18 1995-09-29 Adir Nouveaux dérivés de naphtalène, leur procédé de préparation et les compositions pharmaceutiques qui les contiennent.

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN100421667C (zh) * 2002-04-19 2008-10-01 骨疗国际公司 活性维生素d化合物在制备用于治疗和预防甲状旁腺机能亢进的药物中的应用
CN100349573C (zh) * 2002-09-18 2007-11-21 骨疗国际公司 用于亲脂性药物的制剂
CN105348163A (zh) * 2014-08-18 2016-02-24 武汉启瑞药业有限公司 维生素d类似物及其制备方法和医药用途
CN105348163B (zh) * 2014-08-18 2017-06-16 武汉启瑞药业有限公司 维生素d类似物及其制备方法和医药用途

Also Published As

Publication number Publication date
MX9605206A (es) 1997-04-30
PT771789E (pt) 2000-05-31
BR9605354A (pt) 1998-07-28
DK0771789T3 (da) 2000-06-13
CA2188634A1 (en) 1997-05-01
JPH09165369A (ja) 1997-06-24
US5905074A (en) 1999-05-18
EP0771789A1 (en) 1997-05-07
DE69606680T2 (de) 2000-08-17
JP3059108B2 (ja) 2000-07-04
EP0771789B1 (en) 2000-02-16
AR004700A1 (es) 1999-03-10
ES2144183T3 (es) 2000-06-01
TR199600849A2 (tr) 1997-05-21
DE69606680D1 (de) 2000-03-23
MX198725B (xx) 2000-09-22
GR3033254T3 (en) 2000-09-29
ATE189812T1 (de) 2000-03-15

Similar Documents

Publication Publication Date Title
CN1157818A (zh) 1α，26-二羟基-D-高维生素D3
US5428029A (en) Vitamin D3 fluorinated analogs
EP1863753B1 (en) Trihydroxy polyunsaturated eicosanoid derivatives
CN1054601C (zh) 维生素d3氟化的类似物、其制备方法和用途以及含有该类似物的药物组合物
EP2022775A2 (en) Trihydroxy polyunsaturated eicosanoids
US5292728A (en) 24-Oxa derivatives in the vitamin D series
CA2224440A1 (en) New vitamin d derivatives with substituents at c-25, process for their production, intermediate products and use for the production of pharmaceutical agents
JP3589664B2 (ja) ビタミンｄ系列の２２−エン−２５−オキサ−誘導体，該化合物の製造法，該誘導体を含有する薬学的調剤ならびに薬剤としての該調剤の使用
Zhou et al. Synthesis, biological activity, and conformational analysis of four seco-D-15, 19-bisnor-1α, 25-dihydroxyvitamin D analogues, diastereomeric at C17 and C20
US8461201B2 (en) Trihydroxy polyunsaturated eicosanoid derivatives
EP0579840A1 (en) Fluorine-containing vitamin D3 analogs.
US5039671A (en) Trifluorinated-1α,25S-dihydroxy vitamin D3 compounds
US20090137828A1 (en) Synthesis of 1A-Fluoro-25-Hydroxy-16-23E-Diene-26,27-Bishomo-20-Epi-Cholecalciferol
CA1038378A (en) 13-cis prostaglandin derivatives and methods of making
JPH05201963A (ja) 新規なビタミンｄ３類縁体
Ikeda et al. Synthesis and biological evaluations of A-ring isomers of 26, 26, 26, 27, 27, 27-hexafluoro-1, 25-dihydroxyvitamin D3
US4060691A (en) 7-{3-Hydroxy-2-[4-hydroxy-4-(lower alkyl)-trans-1-octen-1-yl]-5-oxocyclopent-1-yl}heptanoic acids and esters
JP3633639B2 (ja) ビタミンｄ化合物およびそれらの製造方法
AU2012200616B2 (en) Trihydroxy polyunsaturated eicosanoid derivatives
CN1091122A (zh) 二甲基氨基乙酸癸酯的制备方法
Rossi et al. Palladium-catalyzed reaction between aryl or alkenyl halides and (1-carbalkoxy-1-alkenyl) zinc iodides. A new class of unmasked β-substituted acrylate α-anion equivalents
JP2004307420A (ja) 細胞死抑制作用を有する化合物、およびその製造方法
EP0611755A1 (fr) Nouveaux composés (cyclohexyl) alcéniques, leurs procédés de préparation et les compositions pharmaceutiques qui les contiennent
US20120157700A1 (en) Trihydroxy polyunsaturated eicosanoid derivatives
JPS62298572A (ja) １α−ヒドロキシビタミンＤ３の精製法

Legal Events

Date Code Title Description
C06 Publication
PB01 Publication
C10 Entry into substantive examination
SE01 Entry into force of request for substantive examination
C01 Deemed withdrawal of patent application (patent law 1993)
WD01 Invention patent application deemed withdrawn after publication