CN115778887A - Whitening and sunscreen functional composition, preparation method thereof and whitening cream - Google Patents
Whitening and sunscreen functional composition, preparation method thereof and whitening cream Download PDFInfo
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- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
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Abstract
The invention relates to the technical field of cosmetics, and particularly relates to a whitening and sun-screening efficacy composition, a preparation method thereof and a whitening cream, wherein the efficacy composition comprises an atractylodes macrocephala koidz extract, a poria cocos wolf extract and a coix seed extract according to a weight ratio of 4-10. The whitening sunscreen effect composition disclosed by the invention can inhibit the activity of tyrosinase, has a good broad-spectrum sunscreen function, can remove free radicals generated by ultraviolet irradiation on human skin, and has a certain whitening effect; the extraction process for preparing the effective composition has the advantages of simple operation, high extraction efficiency and considerable production cost, and is suitable for large-scale industrial production; the whitening cream containing the whitening and sunscreen functional composition integrates tyrosinase activity inhibition, sunscreen function and antioxidant effect of the functional composition, and has a good whitening effect.
Description
Technical Field
The invention relates to the technical field of cosmetics, and particularly relates to a whitening and sunscreen composition, a preparation method thereof and a whitening cream.
Background
White atractylodes rhizome: floating thistle herb, yushu, dong Bai Zhu, cang Zhu, belonging to Compositae and Atractylodes perennial herb. Pleased in cool climate, has multiple medicinal functions by using rhizome as medicine. Mainly distributed in mountainous wetlands such as Sichuan, yunnan and Guizhou. The rhizoma Atractylodis has effects of invigorating spleen and invigorating qi, eliminating dampness and promoting diuresis, arresting sweating, and preventing miscarriage, and can be used for treating spleen deficiency, anorexia, abdominal distention, diarrhea, phlegm retention and palpitation. Record of "medical enlightenment": the traditional Chinese medicine composition has the effects of removing dampness and benefiting dryness, regulating the middle warmer and replenishing qi, warming the middle warmer, removing dampness in the spleen and stomach, removing stomach heat, strengthening the spleen and stomach, taking food and preventing miscarriage. "
White poria: the white part of the poria cocos is cut off from the poria cocos mass, and the poria cocos is usually used as a traditional Chinese medicine decoction piece. It has very wide effect, is not used in four seasons, can be combined with various medicines, and can play the unique effect regardless of cold, warm, wind and dampness. The white poria cocos is sweet and light in taste and mild in nature, and has the effects of promoting diuresis, excreting dampness, tonifying spleen, harmonizing stomach, calming heart and soothing nerves when being used as a medicine. Modern medical research shows that: poria has effects in enhancing immunity, and pachyman has obvious antitumor and liver protecting effects.
Coix seed: is a Chinese medicinal material used as both medicine and food. Is prepared from Coicis semen of Gramineae by collecting plant in autumn, sun drying, removing fruit, sun drying, removing shell, brown seed coat and impurities, and collecting semen Coicis. It is cool in nature, sweet and bland in flavor. Has effects of invigorating spleen, eliminating dampness, eliminating arthralgia, and relieving diarrhea, and can be used for treating edema, loempe, and dysuresia. The Coicis semen contains Coicis semen ester, and contains fatty oil, wherein the oil contains myristic acid, palmitic acid, 8-octadecenoic acid, stigmasterol, etc., and also contains functional components such as amino acids, proteins, saccharides, etc.
The consumer's view of returning to nature and ' green life ' is prevalent in various industries, and consumers also put higher demands on whitening cosmetics. The Chinese herbal medicine plant cosmetics undoubtedly meet the requirements of consumers, but the application of the Chinese herbal medicines in the whitening cosmetics is less at present, especially for the research and development of effective Chinese herbal medicine plant resources, and it is well known that when medicines with similar performances or effects are applied in a matching way, the original curative effect can be enhanced, and the complementary effect is achieved, so that the Chinese herbal medicine plant cosmetics become one of the main trends of the development of the industries of cosmetics and health care products in the future. According to related data, the research on the application of the combination of the white atractylodes rhizome, the white poria and the coix seed to cosmetics is not reported, so that the invention has potential development value.
Disclosure of Invention
In order to overcome the defects and shortcomings in the prior art, the invention aims to provide a whitening and sunscreen composition, which not only can inhibit the activity of tyrosinase, but also has good broad-spectrum sunscreen function, can remove free radicals generated by ultraviolet irradiation on human skin, and has certain whitening effect.
The invention also aims to provide a preparation method of the whitening and sunscreen composition, which gradually forms a set of extraction process with simple operation, high extraction efficiency and considerable production cost through early comparison and screening, and is suitable for large-scale industrial production.
The invention also aims to provide the whitening cream which contains the whitening and sun-screening effect composition, integrates the tyrosinase activity inhibition, sun-screening function and antioxidant effect of the effect composition, and has better whitening effect.
The purpose of the invention is realized by the following technical scheme: a whitening and sunscreen functional composition comprises an Atractylodes macrocephala extract, a Poria cocos extract and a coix seed extract according to a weight ratio of 4-10.
The efficacy composition disclosed by the invention is composed of the bighead atractylodes rhizome extract, the white poria cocos extract and the coix seed extract according to a specific proportion, can inhibit the activity of tyrosinase, has a good broad-spectrum sunscreen function, can remove free radicals generated by ultraviolet irradiation on human skin, and has a certain whitening effect.
Preferably, the atractylodes macrocephala koidz extract is prepared by the following steps: taking and crushing the white atractylodes rhizome medicinal material, adding an ethanol solution with the mass concentration of 55-65%, then extracting by a heating reflux method at the extraction temperature of 80-90 ℃ for 2-3h, finally filtering the ethanol, decompressing, and concentrating to 2.5 times of the weight of the raw material to obtain the white atractylodes rhizome extract. More preferably, the weight of the added ethanol solution is 23-27 times of the weight of the white atractylodes rhizome medicinal material.
The bighead atractylodes rhizome extract is prepared by adopting the method, the total flavone content of the bighead atractylodes rhizome extract is high, and the total flavone extraction rate of the bighead atractylodes rhizome extract is 5-15% by using an ultraviolet spectrophotometer for analysis and detection.
Preferably, the poria cocos extract is prepared by the following steps:
s1, taking a white poria cocos medicinal material, crushing the white poria cocos medicinal material, adding pure water, then performing microwave extraction, wherein the microwave power is 280-320W, the extraction temperature is 55-65 ℃, the extraction time is 30-50min, and filtering, decompressing and concentrating the white poria cocos medicinal material to 4 times of the weight of the raw material after extraction to obtain a white poria cocos crude extract for later use;
s2, further purifying the poria cocos crude extract obtained in the step S1 through D-101 macroporous resin and eluting with an organic solvent, and concentrating the eluent under reduced pressure to 4 times of the weight of the raw materials to obtain the poria cocos extract; the organic solvent is ethanol.
Preferably, the weight of the added pure water is 28-32 times of that of the medicinal materials of the largehead atractylodes rhizome.
The white poria extract is prepared by adopting the method, and the polysaccharide extraction rate of the white poria extract is 10-30%.
Preferably, the coix seed extract is prepared by the following steps: pulverizing Coicis semen, adding pure water, extracting with ultrasonic-assisted enzyme method at ultrasonic power of 480-520W for 2-3h, filtering, reducing pressure, and concentrating to 4 times of the weight of the raw materials to obtain Coicis semen extract.
Preferably, cellulase accounting for 1.8-2.2% of the total weight of the coix seed medicinal material is added when the extraction is carried out by the ultrasonic-assisted enzyme method; the weight of the pure water added is 28-32 times of that of the coix seed medicinal material.
The coix seed extract is prepared by adopting the method, the polysaccharide extraction rate of the coix seed extract is 5-25%, the extraction efficiency of the method is high, and the purity of the coix seed extract is high.
The invention also provides a preparation method of the whitening and sunscreen composition, which comprises the following steps: mixing the Atractylodis rhizoma extract, poria extract and Coicis semen extract at a certain weight ratio, and stirring to obtain the effective composition.
The whitening sunscreen composition is prepared by adopting the method, and the preparation method gradually forms a set of extraction process which is simple and convenient to operate, high in extraction efficiency and considerable in production cost through early comparison and screening, and is suitable for large-scale industrial production.
The invention also provides whitening cream which comprises the following raw materials in percentage by weight: the functional composition comprises, by weight, 1-10% of an efficacy composition, 4-8% of jojoba oil, 3-4% of cetyl alcohol, 0.08-0.12% of hydroxyethyl cellulose, 4-8% of glyceryl monostearate, 0.6-1.0% of lanolin, 7-8% of avocado oil, 4-8% of glycerol, 1-3% of propylene glycol, 0.8-1.2% of sodium dodecyl sulfate, 0.08-0.12% of carbomer 980, 0.2-0.6% of phenoxyethanol, 0.03-0.07% of essence, 8-12% of citric acid, and the balance deionized water.
Preferably, the whitening cream is prepared by the following steps:
1) Dispersing carbomer 980 into glycerol, stirring, adding 20-30% of deionized water, soaking for 2-4h, and dissolving carbomer completely;
2) Mixing jojoba oil, cetyl alcohol, hydroxyethyl cellulose, glyceryl monostearate, lanolin, and avocado oil according to weight percentage, heating in 70-90 deg.C water bath, stirring for dissolving to obtain phase A;
3) Mixing the carbomer dissolved in the step 1), the glycerol, the propylene glycol, the sodium dodecyl sulfate, the efficacy composition and the rest deionized water according to the weight percentage, putting the mixture into a water bath kettle at the temperature of 70-90 ℃, and stirring to dissolve the mixture to obtain a phase B for later use;
4) Pouring phase A into phase B, stirring, homogenizing for 2-8min, cooling to 40-60 deg.C, adding essence, phenoxyethanol and citric acid, and stirring to obtain whitening cream.
The whitening cream containing the whitening and sun-screening effect composition is prepared from the raw materials and the preparation method, the tyrosinase activity inhibition, the sun-screening function and the antioxidation effect of the effect composition are integrated, the whitening cream has a good whitening effect, and the whitening cream has no potential adverse reaction to skin after being tested.
The invention has the beneficial effects that: the whitening sunscreen composition provided by the invention can inhibit the activity of tyrosinase, has a good broad-spectrum sunscreen function, can remove free radicals generated by ultraviolet irradiation on human skin, and has a certain whitening effect.
According to the preparation method of the whitening and sunscreen composition, a set of extraction process which is simple and convenient to operate, high in extraction efficiency and considerable in production cost is gradually formed through early comparison and screening, and the preparation method is suitable for large-scale industrial production.
The whitening cream contains the whitening and sun-screening effect composition, integrates tyrosinase activity inhibition, sun-screening function and antioxidation of the effect composition, and has a good whitening effect.
Drawings
FIG. 1 is a graphical representation of the results of a tyrosinase inhibition assay performed on the efficacy compositions of example 6;
FIG. 2 is a graph showing the results of different concentrations of antioxidant tests performed on the efficacy composition of example 6.
Detailed Description
For the understanding of those skilled in the art, the present invention will be further described with reference to the following examples and accompanying fig. 1-2, which are not intended to limit the present invention.
Example 1
A whitening and sunscreen functional composition comprises an Atractylodes macrocephala extract, a Poria cocos extract and a coix seed extract according to a weight ratio of 4.
The bighead atractylodes rhizome extract is prepared by the following steps: taking a white atractylodes rhizome medicinal material, crushing the white atractylodes rhizome medicinal material, adding an ethanol solution with the mass concentration of 55%, then extracting by a heating reflux method at the extraction temperature of 80 ℃ for 2 hours, and finally filtering ethanol, decompressing and concentrating to 2.5 times of the weight of the raw material to obtain a white atractylodes rhizome extract; the weight of the added ethanol solution is 23 times of that of the white atractylodes rhizome medicinal material.
The white poria extract is prepared by the following steps:
s1, taking a white poria cocos medicinal material, crushing the white poria cocos medicinal material, adding pure water, then performing microwave extraction, wherein the microwave power is 280W, the extraction temperature is 55 ℃, the extraction time is 30min, and filtering, decompressing and concentrating the white poria cocos medicinal material to 4 times of the weight of the raw material after extraction to obtain a white poria cocos crude extract for later use; adding pure water in an amount which is 28 times of the weight of the rhizoma atractylodis macrocephalae;
s2, further purifying the poria cocos crude extract obtained in the step S1 through D-101 macroporous resin and eluting with ethanol, and concentrating the eluent under reduced pressure to 4 times of the weight of the raw materials to obtain the poria cocos extract.
The coix seed extract is prepared by the following steps: pulverizing Coicis semen, adding pure water, extracting with ultrasonic-assisted enzyme method at ultrasonic power of 480W for 2 hr, filtering, reducing pressure, and concentrating to 4 times of the weight of the raw materials to obtain Coicis semen extract; adding cellulase accounting for 1.8% of the total weight of the coix seed medicinal material when performing ultrasonic-assisted enzyme extraction; the weight of the pure water added is 28 times of that of the coix seed medicinal material.
The preparation method of the whitening and sunscreen composition is prepared by the following steps: mixing and stirring the white atractylodes rhizome extract, the white poria extract and the coix seed extract uniformly according to the weight ratio to obtain the functional composition.
The whitening cream comprises the following raw materials in percentage by weight: efficacy composition 1%, jojoba oil 4%, cetyl alcohol 3%, hydroxyethyl cellulose 0.08%, glyceryl monostearate 4%, lanolin 0.6%, avocado oil 7%, glycerin 4%, propylene glycol 1%, sodium lauryl sulfate 0.8%, carbomer 980.08%, phenoxyethanol 0.2%, essence 0.03%, citric acid 8%, and the balance deionized.
The whitening cream is prepared by the following steps:
1) Dispersing carbomer 980 into glycerol according to the weight percentage, uniformly stirring, adding 20% of the total weight of deionized water, soaking for 2h, and standing by when carbomer is completely dissolved;
2) Mixing jojoba oil, cetyl alcohol, hydroxyethyl cellulose, glyceryl monostearate, lanolin, and avocado oil according to weight percentage, heating in 70 deg.C water bath, stirring for dissolving to obtain phase A;
3) Mixing the carbomer dissolved in the step 1), the glycerol, the propylene glycol, the sodium dodecyl sulfate, the efficacy composition and the rest deionized water according to the weight percentage, heating the mixture in a water bath kettle at 70 ℃, and stirring the mixture to dissolve the mixture to obtain a phase B for later use;
4) Pouring the phase A into the phase B, stirring uniformly, homogenizing for 2min, cooling to 40 ℃, adding essence, phenoxyethanol and citric acid, and stirring uniformly to obtain the whitening cream.
Example 2
A whitening and sunscreen functional composition comprises an Atractylodes macrocephala extract, a Poria cocos extract and a Coix lacryma-jobi seed extract according to a weight ratio of 5.
The bighead atractylodes rhizome extract is prepared by the following steps: taking a white atractylodes rhizome medicinal material, crushing the white atractylodes rhizome medicinal material, adding an ethanol solution with the mass concentration of 58%, then extracting by a heating reflux method at the extraction temperature of 80 ℃ for 2.3 hours, finally filtering the ethanol, and decompressing and concentrating to 2.5 times of the weight of the raw material to obtain a white atractylodes rhizome extract; the weight of the added ethanol solution is 24 times of that of the medicinal material of the largehead atractylodes rhizome.
The white poria extract is prepared by the following steps:
s1, taking a white poria cocos medicinal material, crushing the white poria cocos medicinal material, adding pure water, then performing microwave extraction, wherein the microwave power is 290W, the extraction temperature is 58 ℃, the extraction time is 35min, and filtering, decompressing and concentrating the extract to 4 times of the weight of the raw material after extraction to obtain a white poria cocos crude extract for later use; adding purified water in an amount which is 29 times of the weight of the rhizoma atractylodis macrocephalae;
s2, further purifying the poria cocos crude extract obtained in the step S1 through D-101 macroporous resin and eluting with ethanol, and concentrating the eluent under reduced pressure to 4 times of the weight of the raw materials to obtain the poria cocos extract.
The coix seed extract is prepared by the following steps: pulverizing Coicis semen, adding pure water, extracting with ultrasonic-assisted enzyme method at ultrasonic power of 490W for 2.3 hr, filtering, reducing pressure, and concentrating to 4 times of the weight of the raw materials to obtain Coicis semen extract; adding cellulase accounting for 1.9% of the total weight of the coix seed medicinal material when performing ultrasonic-assisted enzyme extraction; the weight of the pure water added is 29 times of that of the coix seed medicinal material.
The preparation method of the whitening and sunscreen composition is prepared by the following steps: mixing the Atractylodis rhizoma extract, poria extract and Coicis semen extract at a certain weight ratio, and stirring to obtain the effective composition.
The whitening cream comprises the following raw materials in percentage by weight: efficacy composition 3%, jojoba oil 5%, cetyl alcohol 3.5%, hydroxyethyl cellulose 0.09%, glyceryl monostearate 5%, lanolin 0.7%, avocado oil 7.5%, glycerin 5%, propylene glycol 1.5%, sodium lauryl sulfate 0.9%, carbomer 980.09%, phenoxyethanol 0.3%, essence 0.04%, citric acid 9%, and the balance deionized.
The whitening cream is prepared by the following steps:
1) Dispersing carbomer 980 into glycerol according to the weight percentage, uniformly stirring, adding 23% of the total weight of deionized water, soaking for 2.5h, and standing by when carbomer is completely dissolved;
2) Mixing jojoba oil, cetyl alcohol, hydroxyethyl cellulose, glyceryl monostearate, lanolin, and avocado oil according to weight percentage, heating in 70 deg.C water bath, stirring for dissolving to obtain phase A;
3) Mixing the carbomer dissolved in the step 1), the glycerol, the propylene glycol, the sodium dodecyl sulfate, the efficacy composition and the rest deionized water according to the weight percentage, heating the mixture in a water bath kettle at the temperature of 75 ℃, and stirring the mixture to dissolve the mixture to obtain a phase B for later use;
4) Pouring the phase A into the phase B, stirring uniformly, homogenizing for 4min, cooling to 45 ℃, adding essence, phenoxyethanol and citric acid, and stirring uniformly to obtain the whitening cream.
Example 3
A whitening and sunscreen functional composition comprises an Atractylodes macrocephala extract, a Poria cocos extract and a Coix lacryma-jobi seed extract according to a weight ratio of 7.
The bighead atractylodes rhizome extract is prepared by the following steps: taking a white atractylodes rhizome medicinal material, crushing the white atractylodes rhizome medicinal material, adding an ethanol solution with the mass concentration of 60%, then extracting by a heating reflux method at the extraction temperature of 80 ℃ for 2.5 hours, finally filtering ethanol, and decompressing and concentrating to 2.5 times of the weight of the raw material to obtain a white atractylodes rhizome extract; the weight of the added ethanol solution is 25 times of that of the medicinal material of the largehead atractylodes rhizome.
The white poria extract is prepared by the following steps:
s1, taking a white poria cocos medicinal material, crushing the white poria cocos medicinal material, adding pure water, then performing microwave extraction, wherein the microwave power is 300W, the extraction temperature is 60 ℃, the extraction time is 40min, and filtering, decompressing and concentrating the white poria cocos medicinal material to 4 times of the weight of the raw material after extraction to obtain a white poria cocos crude extract for later use; adding pure water in an amount which is 30 times of the weight of the rhizoma atractylodis macrocephalae;
s2, further purifying the poria cocos crude extract obtained in the step S1 through D-101 macroporous resin and eluting with ethanol, and concentrating the eluent under reduced pressure to 4 times of the weight of the raw materials to obtain the poria cocos extract.
The coix seed extract is prepared by the following steps: pulverizing Coicis semen, adding pure water, extracting with ultrasonic-assisted enzyme method at ultrasonic power of 500W for 2.5 hr, filtering, reducing pressure, and concentrating to 4 times of the weight of the raw materials to obtain Coicis semen extract; adding cellulase accounting for 2% of the total weight of the coix seed medicinal material when performing ultrasonic-assisted enzyme extraction; the weight of the pure water added is 30 times of that of the coix seed medicinal material.
The preparation method of the whitening and sunscreen composition is prepared by the following steps: mixing the Atractylodis rhizoma extract, poria extract and Coicis semen extract at a certain weight ratio, and stirring to obtain the effective composition.
The whitening cream comprises the following raw materials in percentage by weight: efficacy composition 5%, jojoba oil 6%, cetyl alcohol 3.5%, hydroxyethyl cellulose 0.10%, glyceryl monostearate 6%, lanolin 0.8%, avocado oil 7.5%, glycerin 6%, propylene glycol 2%, sodium lauryl sulfate 1.0%, carbomer 980.10%, phenoxyethanol 0.4%, essence 0.05%, citric acid 10%, and the balance deionized.
The whitening cream is prepared by the following steps:
1) Dispersing carbomer 980 into glycerol according to the weight percentage, uniformly stirring, adding 25% of the total weight of deionized water, soaking for 3h, and standing by when carbomer is completely dissolved;
2) Mixing jojoba oil, cetyl alcohol, hydroxyethyl cellulose, glyceryl monostearate, lanolin and avocado oil according to weight percentage, heating in a water bath kettle at 80 deg.C, stirring for dissolving to obtain phase A;
3) Mixing the carbomer dissolved in the step 1), the glycerol, the propylene glycol, the sodium dodecyl sulfate, the efficacy composition and the rest deionized water according to the weight percentage, heating the mixture in a water bath kettle at 70 ℃, and stirring the mixture to dissolve the mixture to obtain a phase B for later use;
4) Pouring the phase A into the phase B, stirring uniformly, homogenizing for 5min, cooling to 50 deg.C, adding essence, phenoxyethanol and citric acid, and stirring uniformly to obtain whitening cream.
Example 4
A whitening and sunscreen functional composition comprises an Atractylodes macrocephala extract, a Poria cocos extract and a Coix lacryma-jobi seed extract according to a weight ratio of 8.
The bighead atractylodes rhizome extract is prepared by the following steps: taking a white atractylodes rhizome medicinal material, crushing the white atractylodes rhizome medicinal material, adding an ethanol solution with the mass concentration of 63%, then extracting by a heating reflux method at the extraction temperature of 80 ℃ for 2 hours, and finally filtering ethanol, decompressing and concentrating to 2.8 times of the weight of the raw material to obtain a white atractylodes rhizome extract; the weight of the added ethanol solution is 26 times of that of the medicinal material of the largehead atractylodes rhizome.
The white poria extract is prepared by the following steps:
s1, taking a white poria cocos medicinal material, crushing the white poria cocos medicinal material, adding pure water, then performing microwave extraction, wherein the microwave power is 310W, the extraction temperature is 63 ℃, the extraction time is 45min, and filtering, decompressing and concentrating the white poria cocos medicinal material to 4 times of the weight of the raw material after extraction to obtain a white poria cocos crude extract for later use; adding pure water in an amount which is 31 times of the weight of the rhizoma atractylodis macrocephalae;
s2, further purifying the poria cocos crude extract obtained in the step S1 through D-101 macroporous resin and eluting with ethanol, and concentrating the eluent under reduced pressure to 4 times of the weight of the raw materials to obtain the poria cocos extract.
The coix seed extract is prepared by the following steps: pulverizing Coicis semen, adding pure water, extracting with ultrasonic-assisted enzyme method at ultrasonic power of 510W for 2.8 hr, filtering, reducing pressure, and concentrating to 4 times of the weight of the raw materials to obtain Coicis semen extract; adding cellulase accounting for 2.1% of the total weight of the coix seed medicinal material when performing ultrasonic-assisted enzyme extraction; the weight of the pure water added is 31 times of that of the coix seed medicinal material.
The preparation method of the whitening and sunscreen composition is prepared by the following steps: mixing the Atractylodis rhizoma extract, poria extract and Coicis semen extract at a certain weight ratio, and stirring to obtain the effective composition.
The whitening cream comprises the following raw materials in percentage by weight: the composition comprises, by weight, 8% of an efficacy composition, 7% of jojoba oil, 3.8% of cetyl alcohol, 0.11% of hydroxyethyl cellulose, 7% of glyceryl monostearate, 0.9% of lanolin, 7.8% of avocado oil, 7% of glycerol, 2.5% of propylene glycol, 1.1% of sodium dodecyl sulfate, 980.11% of carbomer, 0.5% of phenoxyethanol, 0.06% of essence, 11% of citric acid and the balance deionized water.
The whitening cream is prepared by the following steps:
1) Dispersing carbomer 980 into glycerol according to the weight percentage, uniformly stirring, adding 28% of the total weight of deionized water, soaking for 3.5h, and standing by when carbomer is completely dissolved;
2) Mixing jojoba oil, cetyl alcohol, hydroxyethyl cellulose, glyceryl monostearate, lanolin and avocado oil according to weight percentage, heating in 85 deg.C water bath, stirring for dissolving to obtain phase A;
3) Mixing the carbomer dissolved in the step 1), the glycerol, the propylene glycol, the sodium dodecyl sulfate, the efficacy composition and the rest deionized water according to the weight percentage, heating the mixture in a water bath kettle at 70 ℃, and stirring the mixture to dissolve the mixture to obtain a phase B for later use;
4) Pouring the phase A into the phase B, stirring uniformly, homogenizing for 7min, cooling to 55 ℃, adding essence, phenoxyethanol and citric acid, and stirring uniformly to obtain the whitening cream.
Example 5
A whitening and sunscreen functional composition comprises an Atractylodes macrocephala extract, a Poria cocos extract and a Coix lacryma-jobi seed extract according to a weight ratio of 10.
The bighead atractylodes rhizome extract is prepared by the following steps: pulverizing Atractylodis rhizoma, adding 65% ethanol solution, extracting at 90 deg.C for 3 hr, filtering ethanol, and concentrating under reduced pressure to 2.5 times of the weight of the raw materials to obtain Atractylodis rhizoma extract; the weight of the added ethanol solution is 27 times of that of the medicinal material of the largehead atractylodes rhizome.
The white poria extract is prepared by the following steps:
s1, taking a white poria cocos medicinal material, crushing the white poria cocos medicinal material, adding pure water, then performing microwave extraction, wherein the microwave power is 320W, the extraction temperature is 65 ℃, the extraction time is 50min, and filtering, decompressing and concentrating the white poria cocos medicinal material to 4 times of the weight of the raw material after extraction to obtain a white poria cocos crude extract for later use; adding pure water in an amount which is 32 times of the weight of the rhizoma atractylodis macrocephalae;
s2, further purifying the poria cocos crude extract obtained in the step S1 through D-101 macroporous resin and eluting with ethanol, and concentrating the eluent under reduced pressure to 4 times of the weight of the raw materials to obtain the poria cocos extract.
The coix seed extract is prepared by the following steps: pulverizing Coicis semen, adding pure water, extracting with ultrasonic-assisted enzyme method at ultrasonic power of 520W for 3 hr, filtering, reducing pressure, and concentrating to 4 times of the weight of the raw materials to obtain Coicis semen extract; adding cellulase accounting for 2.2% of the total weight of the coix seed medicinal material when performing ultrasonic-assisted enzyme extraction; the weight of the pure water added is 32 times of that of the coix seed medicinal material.
The preparation method of the whitening and sunscreen composition is prepared by the following steps: mixing the Atractylodis rhizoma extract, poria extract and Coicis semen extract at a certain weight ratio, and stirring to obtain the effective composition.
The whitening cream comprises the following raw materials in percentage by weight: efficacy composition 10%, jojoba oil 8%, cetyl alcohol 4%, hydroxyethyl cellulose 0.12%, glyceryl monostearate 8%, lanolin 1.0%, avocado oil 8%, glycerin 8%, propylene glycol 3%, sodium lauryl sulfate 1.2%, carbomer 980.12%, phenoxyethanol 0.6%, perfume 0.07%, citric acid 12%, and the balance deionized.
The whitening cream is prepared by the following steps:
1) Dispersing 980 parts of carbomer into glycerol, stirring uniformly, adding 30% of deionized water by weight, soaking for 4h, and standing until carbomer is completely dissolved;
2) Mixing jojoba oil, cetyl alcohol, hydroxyethyl cellulose, glyceryl monostearate, lanolin and avocado oil according to weight percentage, heating in a 90 ℃ water bath kettle, stirring for dissolving to obtain phase A for later use;
3) Mixing the carbomer dissolved in the step 1), the glycerol, the propylene glycol, the sodium dodecyl sulfate, the efficacy composition and the rest deionized water according to the weight percentage, heating the mixture in a water bath kettle at 90 ℃, and stirring the mixture to dissolve the mixture to obtain a phase B for later use;
4) Pouring the phase A into the phase B, stirring uniformly, homogenizing for 8min, cooling to 60 deg.C, adding essence, phenoxyethanol and citric acid, and stirring uniformly to obtain whitening cream.
Example 6
A whitening and sunscreen functional composition comprises an Atractylodes macrocephala extract, a Poria cocos extract and a Coix lacryma-jobi seed extract according to a weight ratio of 6.
The bighead atractylodes rhizome extract is prepared by the following steps: taking a white atractylodes rhizome medicinal material, crushing the white atractylodes rhizome medicinal material, adding an ethanol solution with the mass concentration of 60%, then extracting by a heating reflux method at the extraction temperature of 85 ℃ for 2.5 hours, finally filtering the ethanol, and decompressing and concentrating to 2.5 times of the weight of the raw material to obtain a white atractylodes rhizome extract; the weight of the added ethanol solution is 25 times of that of the white atractylodes rhizome medicinal material.
The white poria extract is prepared by the following steps:
s1, taking a white poria cocos medicinal material, crushing the white poria cocos medicinal material, adding pure water, then performing microwave extraction, wherein the microwave power is 300W, the extraction temperature is 60 ℃, the extraction time is 40min, and filtering, decompressing and concentrating the white poria cocos medicinal material after extraction until the weight of the white poria cocos medicinal material is 4 times of that of the raw material to obtain a white poria cocos crude extract for later use; adding pure water in an amount which is 30 times of the weight of the rhizoma atractylodis macrocephalae;
s2, further purifying the poria cocos crude extract obtained in the step S1 through D-101 macroporous resin and eluting with ethanol, and concentrating the eluent under reduced pressure to 4 times of the weight of the raw materials to obtain the poria cocos extract.
The coix seed extract is prepared by the following steps: pulverizing Coicis semen, adding pure water, extracting with ultrasonic-assisted enzyme method at ultrasonic power of 500W for 2.5 hr, filtering, reducing pressure, and concentrating to 4 times of the weight of the raw materials to obtain Coicis semen extract; adding cellulase accounting for 2% of the total weight of the coix seed medicinal material when performing ultrasonic-assisted enzyme extraction; the weight of the pure water added is 30 times of that of the coix seed medicinal material.
The preparation method of the whitening and sunscreen composition is prepared by the following steps: mixing the Atractylodis rhizoma extract, poria extract and Coicis semen extract at a certain weight ratio, and stirring to obtain the effective composition.
The whitening cream comprises the following raw materials in percentage by weight: efficacy composition 10%, jojoba oil 7%, cetyl alcohol 3.5%, hydroxyethyl cellulose 0.1%, glyceryl monostearate 7%, lanolin 0.7%, avocado oil 7.5%, glycerin 6%, propylene glycol 2%, sodium lauryl sulfate 1%, carbomer 980.1%, phenoxyethanol 0.4%, essence 0.05%, citric acid 10%, and the balance deionized.
The whitening cream is prepared by the following steps:
1) Dispersing carbomer 980 into glycerol according to the weight percentage, uniformly stirring, adding 30% of the total weight of deionized water, soaking for 3h, and standing by when carbomer is completely dissolved;
2) Mixing jojoba oil, cetyl alcohol, hydroxyethyl cellulose, glyceryl monostearate, lanolin and avocado oil according to weight percentage, heating in 85 deg.C water bath, stirring for dissolving to obtain phase A;
3) Mixing the carbomer dissolved in the step 1), the glycerol, the propylene glycol, the sodium dodecyl sulfate, the efficacy composition and the rest deionized water according to the weight percentage, heating the mixture in a water bath kettle at 85 ℃, and stirring the mixture to dissolve the mixture to obtain a phase B for later use;
4) Pouring the phase A into the phase B, stirring uniformly, homogenizing for 7min, cooling to 42 ℃, adding essence, phenoxyethanol and citric acid, and stirring uniformly to obtain the whitening cream.
And (3) experimental test:
1. the efficacy composition prepared in example 6 was subjected to tyrosinase activity inhibition analysis:
tyrosinase is an important catalytic enzyme in the process of melanin generation, and the tyrosinase can inhibit the generation of melanin by inhibiting the activity of tyrosinase, so that the whitening effect is achieved. Firstly, respectively preparing a phosphate buffer solution with the pH value of 6.8, a1 mmol/L-tyrosine solution and a1 mmol/L-tyrosinase solution (stored at 4 ℃), diluting an effect composition stock solution by pure water according to the mass ratio of 20%, dividing an experiment into four groups, accurately adding the phosphate buffer solution, the L-tyrosine solution and a solution to be detected into each group according to the component dosage in the following table 1, uniformly mixing, preserving the temperature at 37 ℃ for 10min, adding a tyrosinase solution into the group A and the group C, fully and uniformly mixing, reacting for 10min, immediately measuring four groups of absorbance values at 475nm after the reaction is finished, recording numerical values, and finding out a result shown in the table 2, wherein the effect compositions 4 and 8 have the strongest inhibition rate on tyrosinase, the inhibition rate of the effect composition is stronger than that when three extracts act independently, further preparing the effect composition 4 into samples with different mass concentrations, carrying out a tyrosinase inhibition rate test, and obtaining a result shown in figure 1, wherein the effect composition gradually increases the tyrosinase inhibition rate and the effect strength tends to be stable in the whitening effect.
TABLE 1
TABLE 2
2. Sunscreen performance test analysis of the efficacy composition prepared in example 6:
the invention adopts Sup>A dilution transmittance method to test the sun-proof performance, firstly, the prepared functional composition is prepared into 12 groups according to the proportion, the stock solution of the composition is diluted by pure water according to the mass proportion of 40 percent, then, the transmittance range of Sup>A sample at each wavelength is measured, wherein the short-wave ultraviolet UV-C is 200-280nm, the medium-wave ultraviolet UV-B is 280-320nm, and the long-wave ultraviolet UV-A is 320-400nm, finally, the average transmittance of the sample at 3 wavelength bands is respectively calculated, the average ultraviolet absorption rate is calculated according to the following formulSup>A, and the average ultraviolet absorption rate = (1-average transmittance) × 100 percent. The results are shown in table 3, wherein the average uv absorbance in the 200-400nm range is maintained above 70%, wherein the average uv absorbance of the efficacy compositions 3 and 4 is the strongest, both exceeding 80%, and is higher than the effect of the three extracts when they are used alone, which suggests that the efficacy composition has a broad spectrum sunscreen function and can be used as a natural functional extract in sunscreen cosmetics.
TABLE 3
3. Antioxidant performance test of the efficacy composition prepared in example 6:
the invention selects the clearance test of DPPH free radical and ABTS free radical to evaluate the antioxidation property of the efficacy composite, the two methods are the more classical analysis methods of antioxidation ability, and the operation is simple and convenient, the precision and repeatability are high, the result is reliable, firstly, DPPH ethanol solution with the concentration of 0.1mmol/L is prepared, then, sample solution with the mass concentration of 50, 60, 70, 80, 90, 100mg/mL is prepared respectively, 2.0mL sample solution is taken to be mixed with 2.0mL DPPH ethanol solution evenly, after standing for 20min in a dark place at room temperature, the absorbance value A of the mixed solution at 518nm is detected by a multifunctional microplate reader, the numerical value is recorded, trolox is taken as the positive control group in the test, and the clearance = [1- (A1-A2)/A0 ] is multiplied by 100%.
Secondly, accurately weighing 0.0384g of ABTS and 0.0134g of potassium persulfate, fixing the volume to 10mL, mixing the two reagents in equal quantity, reacting for 10 hours in a dark place to obtain ABTS +. Working solution, and diluting the working solution by 15 times with PBS before use. Then preparing sample solution with mass concentration of 50, 60, 70, 80, 90 and 100mg/mL, uniformly mixing 1.0mL of sample solution and 3.0mL of ABTS +. Working solution, placing the mixture in a water bath at 25 ℃ in a dark place for reaction for 20min, detecting the absorbance value A of the mixed solution at 734nm by using a multifunctional microplate reader, and recording a numerical value, wherein the test uses Trolox as a positive control, and the clearance rate is = [1- (A1-A2)/A0 ]. Times 100%. The specific test results are shown in table 4, it can be known from the table that the efficacy composition of bighead atractylodes rhizome, white poria and coix seed has obvious capacity of removing DPPH free radicals and ABTS free radicals, wherein the average antioxidant capacity of the efficacy compositions 4, 8 and the extract of white poria is strongest, further the efficacy composition 4 is taken to carry out antioxidant tests with different concentrations, as shown in fig. 2, the antioxidant capacity of the efficacy composition is in a certain dose-effect relationship, the clearance rate of DPPH free radicals and ABTS free radicals is enhanced along with the increase of the mass concentration of the efficacy composition and Trolox, and then the efficacy composition gradually tends to be mild, when the concentration is 90mg/mL, the clearance effect of the efficacy composition and a positive control Trolox is close to be strongest, at the moment, the clearance rate of the oxidative free radicals exceeds 80%, namely, the efficacy composition has the capacity of directly removing Reactive Oxygen Species (ROS) in vitro, and the three extracts have a synergistic effect in antioxidant aspect, and can be applied to cosmetics as a potential natural antioxidant.
TABLE 4
4. Safety evaluation of the whitening cream prepared in example 6:
the safety of the prepared whitening cream is evaluated according to a skin-closed patch test on the technical standards for cosmetic safety 2015 edition. Test subjects: 30 volunteers between 18 and 60 years old who meet the requirements of the test were selected as subjects. The test method comprises the following steps: the qualified spot test device with the area not more than 50mm2 and the depth of about 1mm is selected. The test article was placed in a plaque chamber at about 0.025g and the control well was blank (no material placed). The spot test device with the test substance is applied to the curved side of the forearm of the test subject by using a 3M original medical water-blocking adhesive tape, and is uniformly applied to the skin by lightly pressing with the palm for 24 hours. Skin reactions were observed at standard 30min (after disappearance of the indentation), 24h and 48h after removal of the test article plaque test device, respectively, and the observations were recorded as in table 5 below.
TABLE 5
And (3) test results:
the spot-pasting test results of 30 volunteers are negative, which shows that the whitening cream prepared by the invention has no potential adverse reaction on skin.
5. A further human whitening efficacy test was performed on the whitening cream product prepared in example 6:
subject person: a total of 36 volunteers, including 15 men and 21 women, aged between 25-45 years, had no history of skin allergy, and were divided into 3 groups of 5 men and 7 women each, and three groups were tried with three gradient whitening cream products, without smearing other products with similar efficacy during the test. The detection method comprises the following steps: the whitening cream is smeared on a specific area of the face, the whitening cream is used once in the morning and at night, after continuous testing is carried out for 30 days, the using effect and adverse reaction are observed, facial conditions of a volunteer before and after use are photographed by using a facial Image analyzer VISIA-CR, and a facial Lab value and a stain value are analyzed and recorded by using Image-Pro Image analysis software. The volunteers do not have the adverse phenomena of pruritus, redness and swelling and the like in the using process, the self-evaluation results are shown in table 6, the whitening cream with the addition amount of 5% is selected according to the results to carry out a human body whitening efficacy test, representative spot counts and spot area ratios are selected from the test results to carry out evaluation and analysis, the detailed results are shown in table 7, the results in the table show that the skin whiteness and the skin brightness of 10 persons are increased due to the fact that the number of spots of the subjects with different degrees is reduced, the spot color becomes light and the area ratio is reduced, and the effect composition of the bighead atractylodes rhizome, the poria cocos and the coix seed has good whitening effect.
TABLE 6
TABLE 7
Wherein the OD value of the spots is the optical density, and ranges from 0 to 255, and lower values indicate darker spots and lighter spots with higher spots. The value of L represents the brightness, and the higher the value is, the higher the brightness of the skin is; ITAO values represent skin yellowness, with greater values leading to whiter skin.
The above-described embodiments are preferred implementations of the present invention, and the present invention can be implemented in other ways without departing from the spirit of the present invention.
Claims (10)
1. The whitening and sunscreen functional composition is characterized by comprising the following components in parts by weight: the effective composition comprises an atractylodes macrocephala koidz extract, a poria cocos wolf extract and a coix seed extract according to a weight ratio of 4-10.
2. The whitening and sunscreen composition as claimed in claim 1, wherein: the bighead atractylodes rhizome extract is prepared by the following steps: pulverizing Atractylodis rhizoma, adding 55-65% ethanol solution, extracting at 80-90 deg.C for 2-3 hr by heating and refluxing, filtering ethanol, and concentrating under reduced pressure to 2.5 times of the weight of the raw materials to obtain Atractylodis rhizoma extract.
3. The whitening and sunscreen composition according to claim 2, wherein: the weight of the added ethanol solution is 23-27 times of that of the medicinal material of the largehead atractylodes rhizome.
4. The whitening and sunscreen composition according to claim 1, wherein: the white poria extract is prepared by the following steps:
s1, taking a white poria cocos medicinal material, crushing the white poria cocos medicinal material, adding pure water, then performing microwave extraction, wherein the microwave power is 280-320W, the extraction temperature is 55-65 ℃, the extraction time is 30-50min, and filtering, decompressing and concentrating the white poria cocos medicinal material to 4 times of the weight of the raw material after extraction to obtain a white poria cocos crude extract for later use;
s2, further purifying the poria cocos crude extract obtained in the step S1 through D-101 macroporous resin and eluting with an organic solvent, and concentrating the eluent under reduced pressure to 4 times of the weight of the raw materials to obtain the poria cocos extract.
5. The whitening and sunscreen composition as claimed in claim 4, wherein: the weight of the added pure water is 28-32 times of that of the medicinal material of the largehead atractylodes rhizome.
6. The whitening and sunscreen composition as claimed in claim 1, wherein: the coix seed extract is prepared by the following steps: pulverizing Coicis semen, adding pure water, extracting with ultrasonic-assisted enzyme method at ultrasonic power of 480-520W for 2-3h, filtering, reducing pressure, and concentrating to 4 times of the weight of the raw materials to obtain Coicis semen extract.
7. The whitening and sunscreen composition according to claim 6, wherein: adding cellulase accounting for 1.8-2.2% of the total weight of Coicis semen when performing ultrasonic-assisted enzymatic extraction; the weight of the added pure water is 28-32 times of the weight of the coix seed medicinal material.
8. A method for preparing a whitening sunscreen composition according to any one of claims 1 to 7, comprising: is prepared by the following steps: mixing the Atractylodis rhizoma extract, poria extract and Coicis semen extract at a certain weight ratio, and stirring to obtain the effective composition.
9. A whitening cream is characterized in that: comprises the following raw materials in percentage by weight: the efficacious composition of any of claims 1-7 comprising 1-10%, jojoba oil 4-8%, cetyl alcohol 3-4%, hydroxyethyl cellulose 0.08-0.12%, glyceryl monostearate 4-8%, lanolin 0.6-1.0%, avocado oil 7-8%, glycerin 4-8%, propylene glycol 1-3%, sodium lauryl sulfate 0.8-1.2%, carbomer 980.08-0.12%, phenoxyethanol 0.2-0.6%, perfume 0.03-0.07%, citric acid 8-12%, and the balance deionized.
10. The whitening cream of claim 9, wherein: the whitening cream is prepared by the following steps:
1) Dispersing carbomer 980 into glycerol according to the weight percentage, uniformly stirring, adding 20-30% of the total weight of deionized water, soaking for 2-4h, and standing for later use after the carbomer is completely dissolved;
2) Mixing jojoba oil, cetyl alcohol, hydroxyethyl cellulose, glyceryl monostearate, lanolin, and avocado oil at 70-90 deg.C, stirring to dissolve, and making into phase A;
3) Mixing the carbomer dissolved in the step 1), the glycerol, the propylene glycol, the sodium dodecyl sulfate, the efficacy composition and the rest deionized water according to the weight percentage, putting the mixture into a water bath kettle at the temperature of 70-90 ℃, and stirring to dissolve the mixture to obtain a phase B for later use;
4) Pouring phase A into phase B, stirring, homogenizing for 2-8min, cooling to 40-60 deg.C, adding essence, phenoxyethanol and citric acid, and stirring to obtain whitening cream.
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