CN113797132A - Whitening sunscreen composition, preparation method thereof and whitening sunscreen emulsion containing composition - Google Patents
Whitening sunscreen composition, preparation method thereof and whitening sunscreen emulsion containing composition Download PDFInfo
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- CN113797132A CN113797132A CN202111186648.9A CN202111186648A CN113797132A CN 113797132 A CN113797132 A CN 113797132A CN 202111186648 A CN202111186648 A CN 202111186648A CN 113797132 A CN113797132 A CN 113797132A
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Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
- A61K8/9783—Angiosperms [Magnoliophyta]
- A61K8/9789—Magnoliopsida [dicotyledons]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q17/00—Barrier preparations; Preparations brought into direct contact with the skin for affording protection against external influences, e.g. sunlight, X-rays or other harmful rays, corrosive materials, bacteria or insect stings
- A61Q17/04—Topical preparations for affording protection against sunlight or other radiation; Topical sun tanning preparations
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/02—Preparations for care of the skin for chemically bleaching or whitening the skin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
- A61K2800/59—Mixtures
- A61K2800/592—Mixtures of compounds complementing their respective functions
- A61K2800/5922—At least two compounds being classified in the same subclass of A61K8/18
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/74—Biological properties of particular ingredients
- A61K2800/78—Enzyme modulators, e.g. Enzyme agonists
- A61K2800/782—Enzyme inhibitors; Enzyme antagonists
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/80—Process related aspects concerning the preparation of the cosmetic composition or the storage or application thereof
- A61K2800/805—Corresponding aspects not provided for by any of codes A61K2800/81 - A61K2800/95
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- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Dermatology (AREA)
- Engineering & Computer Science (AREA)
- Biotechnology (AREA)
- Botany (AREA)
- Microbiology (AREA)
- Mycology (AREA)
- Birds (AREA)
- Epidemiology (AREA)
- Cosmetics (AREA)
Abstract
The invention relates to a whitening sunscreen composition, a preparation method thereof and whitening sunscreen emulsion containing the composition. The whitening sunscreen composition is characterized by being prepared by combining extract compositions of a Berchemia gambir extract, a dill leaf extract and a ophiorrhiza pumila extract, wherein the proportion of the Berchemia gambir extract to the dill leaf extract to the ophiorrhiza pumila extract is 5-6: 2-3: 3-4, preparing the whitening sunscreen composition into an emulsion containing 10-12% of the whitening sunscreen composition, and preparing the whitening sunscreen emulsion containing the composition. The whitening sunscreen composition is prepared from natural plants, can effectively absorb ultraviolet rays and inhibit tyrosinase activity so as to inhibit the formation of melanin, is prepared into an emulsion, is convenient to use, is safe and non-irritant, and can exert the effects of whitening and sunscreen.
Description
Technical Field
The invention relates to a whitening sunscreen composition, in particular to a whitening sunscreen composition formed by combining a Berchemia gambir extract, a dill extract and a ophiorrhiza pumila extract, a preparation method thereof and a whitening sunscreen emulsion containing the composition, and belongs to the field of daily chemicals.
Background
With the progress of human concept, more and more people are concerned about the damage of ultraviolet rays to human bodies and actively seek various daily chemicals to protect our skins. The damage of ultraviolet rays to human skin not only causes common skin problems such as skin darkness, pigmentation, color spots and the like, but also has a certain carcinogenic probability under serious conditions. The number of people suffering from skin cancer increases every year, but the cure rate of skin cancer is low, so that the protection of skin becomes a key concern. Meanwhile, with the improvement of living standard of people, the demands of people on daily chemicals such as whitening, sun screening and the like are transited from the common demands of meeting the whitening and sun screening to the demands of pursuing more healthy and harmless skin. The partial whitening sunscreen product contains certain chemical reagents and can also cause certain burden on the skin, and the advantages of the natural plant extract in the aspect are obvious. Therefore, the development of green and safe whitening sunscreen components is an important subject of the research and development of daily chemicals.
The color of the skin depends mainly on the amount of melanin content in the epidermis. Tyrosinase is the main rate-limiting enzyme in the process of melanin formation, and the activity of the enzyme directly determines the amount of melanin formation. If the activity of the enzyme is too strong or the content of the enzyme is too high, a strong reaction can be caused, so that the generation of a large amount of melanin is initiated, and hypermelanosis, such as melanoma, freckle, chloasma and the like, can be caused. Therefore, the formation of cell melanin can be reduced to a certain extent by inhibiting the activity of tyrosinase, the generation of a large amount of melanin substances can be prevented, and the real skin whitening can be realized.
The Berchemia gambir wild resources are rich, and the Berchemia gambir has a great development and utilization value. The plant is a folk traditional medicinal and tea plant, and the root and stem of the plant can be used as medicine, and has multiple effects of relieving cough and asthma, inhibiting bacteria, protecting liver, resisting tumor and the like. The tender leaves can be used as tea, and has effects of protecting liver, caring skin, lowering blood pressure and blood lipid, etc. Therefore, the method has high research and application values.
Dill is native to Europe, is planted in every part of the south and the north of China and is an indispensable seasoning spice in western cuisine. Dill has a sedative effect for alleviating pain and is often used to treat headache, to strengthen the stomach and regulate the bowel, to eliminate bad breath and to alleviate diabetes and hypertension. The stems, leaves and seeds of dill contain essential oil, and the seed content is the most abundant. Researches show that the dill essential oil has certain antioxidant and bacteriostatic effects.
The herba Hedyotis Diffusae is perennial herb of genus Serpentis of family Rubiaceae of order Rubiales. Plants of this genus are not common everywhere due to limitations on growth conditions. But it contains terpenes, anthraquinones and abundant alkaloids, the whole herb can be used as medicine, has the effects of activating blood circulation, dissipating blood stasis, clearing lung and eliminating phlegm, and has good development prospect. The content of chlorogenic acid in the ophiorrhiza pumila flowers is high, and the pharmacological action of the chlorogenic acid is clinically used for treatment of antibiosis, antiphlogosis, detoxification, oxygen radical removal and cancer resistance.
The inventor finally obtains the whitening sunscreen composition with the optimal proportion through a large number of formula proportion research experiments, and proves the positive effect of the whitening sunscreen composition in whitening sunscreen, and thus the invention is completed. The invention provides a whitening sunscreen composition and a preparation method of a whitening sunscreen emulsion containing the composition.
Disclosure of Invention
The first purpose of the invention is to provide a whitening sunscreen composition which is convenient in plant source, simple in extraction method, and has the effects of absorbing ultraviolet rays, inhibiting tyrosinase activity, inhibiting melanin formation and the like.
The second purpose of the invention is to provide a preparation method of the whitening sunscreen composition.
The third object of the invention is to provide a whitening sunscreen lotion containing the whitening sunscreen composition and a preparation method thereof.
The invention provides a whitening sunscreen composition, which is prepared from Berchemia gambir extractive solution, dill extractive solution and ophiorrhiza pumila extractive solution in a proportion of 5-6: 2-3: 3-4.
The whitening sunscreen composition comprises Berchemia gambir extractive solution, dill extractive solution and herba Hedyotidis Diffusae extractive solution at a ratio of 5:2: 3.
Preferably, the preparation method of the extract of Berchemia gambir in the whitening sunscreen composition comprises the following steps:
taking supple gambir, drying, crushing, sieving by a 60-mesh sieve, placing in a round bottom flask, adding 10 times of distilled water for soaking for 30min, then adding 0.5% cellulase and 0.3% pectinase for slight stirring, adjusting the pH to 4.8 by hydrochloric acid, placing in a constant temperature oscillator at 40 ℃ for enzymolysis for 30min, moving to an electric heating jacket for heating and boiling for 2h, filtering to obtain filtrate, adding 85% ethanol to ensure that the alcohol content reaches 60%, standing for 24h, filtering to obtain filtrate, adding 85% ethanol to filter residue to ensure that the alcohol content reaches 60%, standing for 24h, filtering to obtain filtrate, combining the two filtrates, placing in a rotary evaporator for recovering ethanol until no alcohol smell exists, and concentrating to 1g/ml equivalent to that of a crude medicinal material to obtain supple gambir extract;
the preparation method of the dill leaf extracting solution in the whitening sunscreen composition comprises the following steps:
taking dill leaves, drying, crushing, sieving with a 80-mesh sieve, placing in a round-bottom flask, adding 6 times of distilled water, then adding 1% cellulase, slightly stirring, adjusting the pH to 5.0 by hydrochloric acid, placing in a constant-temperature oscillator at 45 ℃ for enzymolysis for 45min, placing in a water bath, adjusting the temperature to 80 ℃, connecting with a condensing tube for reflux extraction for 2 times, 2 hours each time, filtering, combining filtrates, concentrating, adding ethyl acetate for extraction until an extraction layer is colorless, combining extract liquor, placing in a rotary evaporator for recovering ethyl acetate, and concentrating to 0.5g/ml equivalent to crude drugs to obtain a dill leaf extract;
the preparation method of the ophiorrhiza pumila extract in the whitening sunscreen composition comprises the following steps:
taking the snakegourd, drying, crushing, sieving with a 80-mesh sieve, placing in a triangular flask with a stopper, adding 60% ethanol in an amount which is 3 times that of the snakegourd, extracting for 3 times in an ultrasonic oscillator by ultrasonic oscillation at the ultrasonic frequency of 60KHz and the temperature of 60 ℃, filtering and combining filtrates, recovering ethanol by using a rotary evaporator, and concentrating to 1.2g/ml equivalent to that of a crude drug to obtain a snakegourd extracting solution;
selecting Berchemia gambir extractive solution, Anethum graveolens extractive solution and herba Hedyotidis Diffusae extractive solution according to a certain proportion, and mixing well for use; taking 1g of chitosan, adding 1% glacial acetic acid, putting the chitosan into a 100mL volumetric flask for constant volume, uniformly mixing, swelling for 24 hours, and preparing a chitosan solution with the concentration of 1% for later use; adjusting pH of the prepared crude liquid of the extractive solution mixture to 6.0 with 1% acetic acid, placing in a beaker, adding the prepared chitosan solution (1 ml chitosan solution is added to each 10ml extractive solution), stirring well, and standing for 2 h. Transferring into clean dry centrifuge tube, centrifuging at 4000r/min for 10min, and filtering with absorbent cotton to obtain the whitening sunscreen composition.
A whitening sunscreen emulsion containing the whitening sunscreen composition comprises the following raw materials in percentage by weight: the whitening and sun-protecting composition according to claim 1, which comprises 10-12% of white vaseline 3-5%, 2-6% of lanolin, 2-4% of oil-soluble vitamin E, 3-5% of glyceryl monostearate, 3-5% of dimethicone, 0.1-0.2% of propyl paraben, 0.5-1% of stearyl alcohol, 3-5% of glycerol, 1-3% of amino acid humectant, 0.2-0.5% of essence and deionized water added to 100%.
The preparation method of the whitening sunscreen emulsion containing the whitening sunscreen composition comprises the following steps: white vaseline, lanolin, oil-soluble vitamin E, glyceryl monostearate, dimethicone, propyl p-hydroxybenzoate and stearyl alcohol as oil phase, and heating to 80 deg.C in water bath to dissolve completely and form homogeneous phase; putting glycerol, amino acid humectant and deionized water as water phase on a water bath kettle, heating to 80 deg.C until completely dissolved to form homogeneous phase for use; slowly adding the oil phase into the water phase in a trickle state under continuous stirring, stirring in the same direction, and stirring for 10min at the temperature of 80 ℃; gradually cooling to about 55 deg.C under continuously stirring, adding the above extract composition into the cream matrix, stirring for 5min, adding appropriate amount of essence, and cooling to obtain whitening sunscreen emulsion containing the whitening sunscreen composition.
The whitening sunscreen composition has the following beneficial effects in the field of whitening sunscreen emulsion:
1. the whitening sunscreen composition disclosed by the invention is derived from natural plants, is low in price and easy to obtain, is simple in process, can enrich effective active ingredients, can play a role durably and stably, does not rebound, does not have toxic or side effect, and is suitable for short-term sun protection and long-term whitening.
2. The inventor originally combines the Berchemia gambir extractive solution, the dill extractive solution and the snakeweed extractive solution, and determines the dosage proportion among the components through a large number of experiments, so that the extractive solution composition has an obvious synergistic effect, can effectively absorb ultraviolet rays and inhibit tyrosinase activity so as to inhibit the formation of melanin, and can be prepared into an emulsion, so that the emulsion is convenient to use, is safe and non-irritant, and can exert the effects of whitening and sun-screening.
Detailed Description
The technical solution of the present invention is further described with reference to the following specific examples.
Example 1 preparation of whitening sunscreen emulsion containing whitening sunscreen composition
The first step is as follows: preparation of whitening sunscreen composition
The preparation method of the Berchemia gambir extractive solution comprises the following steps:
taking supple gambir, drying, crushing, sieving by a 60-mesh sieve, placing in a round bottom flask, adding 10 times of distilled water for soaking for 30min, then adding 0.5% cellulase and 0.3% pectinase for slight stirring, adjusting the pH to 4.8 by hydrochloric acid, placing in a constant temperature oscillator at 40 ℃ for enzymolysis for 30min, moving to an electric heating jacket for heating and boiling for 2h, filtering to obtain filtrate, adding 85% ethanol to ensure that the alcohol content reaches 60%, standing for 24h, filtering to obtain filtrate, adding 85% ethanol to filter residue to ensure that the alcohol content reaches 60%, standing for 24h, filtering to obtain filtrate, combining the two filtrates, placing in a rotary evaporator for recovering ethanol until no alcohol smell exists, and concentrating to 1g/ml equivalent to that of a crude medicinal material to obtain supple gambir extract;
the preparation method of the dill leaf extract comprises the following steps:
taking dill leaves, drying, crushing, sieving with a 80-mesh sieve, placing in a round-bottom flask, adding 6 times of distilled water, then adding 1% cellulase, slightly stirring, adjusting the pH to 5.0 by hydrochloric acid, placing in a constant-temperature oscillator at 45 ℃ for enzymolysis for 45min, placing in a water bath, adjusting the temperature to 80 ℃, connecting with a condensing tube for reflux extraction for 2 times, 2 hours each time, filtering, combining filtrates, concentrating, adding ethyl acetate for extraction until an extraction layer is colorless, combining extract liquor, placing in a rotary evaporator for recovering ethyl acetate, and concentrating to 0.5g/ml equivalent to crude drugs to obtain a dill leaf extract;
the preparation method of the ophiorrhiza pumila extract comprises the following steps:
taking the snakegourd, drying, crushing, sieving with a 80-mesh sieve, placing in a triangular flask with a stopper, adding 60% ethanol in an amount which is 3 times that of the snakegourd, extracting for 3 times in an ultrasonic oscillator by ultrasonic oscillation at the ultrasonic frequency of 60KHz and the temperature of 60 ℃, filtering and combining filtrates, recovering ethanol by using a rotary evaporator, and concentrating to 1.2g/ml equivalent to that of a crude drug to obtain a snakegourd extracting solution;
selecting the Berchemia gambir extractive solution, the dill leaf extractive solution and the ophiorrhiza japonica extractive solution according to the ratio of 5:2:3, and uniformly mixing for later use; taking 1g of chitosan, adding 1% glacial acetic acid, putting the chitosan into a 100mL volumetric flask for constant volume, uniformly mixing, swelling for 24 hours, and preparing a chitosan solution with the concentration of 1% for later use; adjusting pH of the prepared crude liquid of the extractive solution mixture to 6.0 with 1% acetic acid, placing in a beaker, adding the prepared chitosan solution (1 ml chitosan solution is added to each 10ml extractive solution), stirring well, and standing for 2 h. Transferring into clean dry centrifuge tube, centrifuging at 4000r/min for 10min, and filtering with absorbent cotton to obtain the whitening sunscreen composition.
The second step is that: the whitening sunscreen composition is prepared into whitening sunscreen lotion.
Preparation of sunscreen containing whitening sunscreen composition:
the raw material components and the content of the sunscreen lotion containing the whitening sunscreen composition are shown in table 1.
Table 1 formula of sunscreen containing whitening sunscreen composition
The preparation process comprises the following steps:
white vaseline, lanolin, oil-soluble vitamin E, glyceryl monostearate, dimethicone, propyl p-hydroxybenzoate and stearyl alcohol as oil phase, and heating to 80 deg.C in water bath to dissolve completely and form homogeneous phase; putting glycerol, amino acid humectant and deionized water as water phase on a water bath kettle, heating to 80 deg.C until completely dissolved to form homogeneous phase for use; slowly adding the oil phase into the water phase in a trickle state under continuous stirring, stirring in the same direction, and stirring for 10min at the temperature of 80 ℃; gradually cooling to about 55 deg.C under continuously stirring, adding the above cream matrix into the extractive solution composition, stirring for 5min, adding appropriate amount of essence, and cooling to obtain sunscreen emulsion containing the whitening sunscreen composition.
Test example 1
Tyrosinase inhibition experiment of the whitening sunscreen composition of the invention:
1. materials and methods
1.1 test materials
The uncaria extract, the dill extract and the serpentium herb extract were prepared according to the above embodiment, respectively, and the whitening sunscreen composition of the present invention (sample 1) was prepared at a ratio of 5:2: 3. Preparing a composition extract of the Berchemia gambir extract and the dill extract according to the same method and the same proportion (sample 2, the common hop extract is replaced by the same amount of distilled water); a composition extract of the supple catechu extract and the ophiorrhiza japonica extract (sample 3, the dill extract was replaced with distilled water of the same amount); a combination of dill extract and ophiorrhiza pumila extract (sample 4, supplejack extract was replaced with equal amount of distilled water).
1.2 test methods
(1) The following Table 2 was added and the solution was allowed to react at room temperature for 3.5h, then 2mL was quickly transferred to a 3mL cuvette and its absorbance value was measured at 475nm, 3 replicates per group.
(2) Tyrosinase inhibitory activity (%) was calculated according to the following formula.
In the formula: a. the1: adding only the absorbance value of L-tyrosinase without adding a sample; a. the2: without addition of sample and L-tyrosine(ii) absorbance value of the enzyme; a. the3: adding the absorbance values of the sample and L-tyrosinase; a. the4: the absorbance values for the samples were added only. To eliminate systematic errors caused by water in parallel, at A1And A230 μ l of deionized water was added to each well of the set.
TABLE 2 determination of tyrosinase inhibition
2. Results and analysis
The tyrosinase inhibition rate for each sample is shown in table 3.
TABLE 3 tyrosinase inhibition test results for each sample
*p<0.05, compared to sample 1;#p<0.01, compared to sample 2;△p<0.01, compared to sample 3.
As can be seen from table 3, each sample had an effect of inhibiting tyrosinase, indicating that the sample had an effect of inhibiting melanin formation, thereby achieving a whitening effect. The tyrosinase inhibition rate of the sample 1 is the highest, and compared with the samples 2, 3 and 4 respectively, the data have obvious statistical significance, so that the composition of the 3 natural plant extracting solutions is good in whitening effect, and the tyrosinase inhibition rate is reduced due to the lack of any one of the natural plant extracting solutions.
3. Conclusion
The whitening sunscreen composition has higher tyrosinase inhibition rate and better whitening effect.
Test example 2
The invention discloses a whitening sunscreen composition and sunscreen emulsion sunscreen ultraviolet index detection containing the same:
1. materials and methods
1.1 test materials
Samples 1, 2, 3 and 4 were prepared in the same manner as in test example 1. A whitening sunscreen emulsion containing the whitening sunscreen composition of the present invention was prepared as in example (sample 5).
1.2 test methods
(1) And switching on a power supply of an ultraviolet spectrophotometer instrument and preheating for 15 min.
(2) Setting detection wavelengths of 280, 290, 300, 310, 320, 330, 340, 350, 360, 370 and 380nm, respectively placing the cuvettes in the sample light path and the reference light path, and adjusting the zero point of the instrument.
(3) Placing 2mL of samples to be detected in a sample light path respectively at 1-4, uniformly smearing sunscreen emulsion containing whitening sunscreen composition prepared from sample 5 on one side light-transmitting surface of quartz cuvette to make the concentration of sunscreen emulsion on the surface of the cuvette 5mg/cm2And the other quartz cuvette is arranged in a reference light path, the ultraviolet absorbance values of 11 wavelengths of each group of samples are respectively measured, the measurement is repeated for 3 times, and the average value of each wavelength is taken.
(4) And respectively calculating the absorbance average values of the sample to be detected in the UVB area and the UVA area.
(5) And evaluating the test result according to the evaluation standard of the sunscreen in UVB region and UVA region by an ultraviolet spectrophotometry. The method comprises the following steps: the A value is more than 0.5 and less than 1.0, and the minimum ultraviolet protection effect is achieved; 1.1< A <1.5, has medium protection effect on ultraviolet light; 1.6< A <2.0, has high ultraviolet radiation protection effect; the A value is more than 2.1, and the ultraviolet radiation protection effect is completely realized.
2. Results and analysis
The results of the UV index measurements are shown in Table 4.
TABLE 4 Absorbance detection results of each sample in the ultraviolet band range
As can be seen from Table 4, each sample absorbed to a different extent in both the UVB and UVA ranges, suggesting that the sample has the effect of absorbing ultraviolet light, thereby achieving a sunscreen effect. The absorbance of sample 1 and sample 5 was particularly high. Sample 1 is the whitening sunscreen composition of the present invention, which can achieve a complete sunscreen ultraviolet protection effect in the UVB region, a high-efficiency sunscreen ultraviolet protection effect in the UVA region, and a better protection effect against ultraviolet rays; the whitening sunscreen emulsion containing the whitening sunscreen composition prepared in the sample 5 can achieve the complete protection effect on ultraviolet rays in both UVB region and UVA region. The whitening sunscreen compositions prepared in samples 1-3 can achieve a medium-effect sunscreen ultraviolet effect in the UVB region and a low-effect sunscreen ultraviolet effect in the UVA region, and the ultraviolet protection effect is reduced to different degrees compared with that of sample 1, which shows that the whitening sunscreen composition provided by the invention can play a synergistic role, and the sunscreen effect is reduced due to the lack of any one of the compositions.
3. Conclusion
The whitening sunscreen composition and the whitening sunscreen emulsion containing the same have high absorption in UVB and UVA ranges, and have good sunscreen effect.
Claims (4)
1. The whitening sunscreen composition is characterized by being prepared by combining extract liquid compositions of a Berchemia gambir extract, a dill leaf extract and a ophiorrhiza pumila extract, wherein the proportion of the Berchemia gambir extract, the dill leaf extract and the ophiorrhiza pumila extract is 5-6: 2-3: 3-4;
the preparation method of the Berchemia gambir extractive solution comprises the following steps:
taking supple gambir, drying, crushing, sieving by a 60-mesh sieve, placing in a round bottom flask, adding 10 times of distilled water for soaking for 30min, then adding 0.5% cellulase and 0.3% pectinase for slight stirring, adjusting the pH to 4.8 by hydrochloric acid, placing in a constant temperature oscillator at 40 ℃ for enzymolysis for 30min, moving to an electric heating jacket for heating and boiling for 2h, filtering to obtain filtrate, adding 85% ethanol to ensure that the alcohol content reaches 60%, standing for 24h, filtering to obtain filtrate, adding 85% ethanol to filter residue to ensure that the alcohol content reaches 60%, standing for 24h, filtering to obtain filtrate, combining the two filtrates, placing in a rotary evaporator for recovering ethanol until no alcohol smell exists, and concentrating to 1g/ml equivalent to that of a crude medicinal material to obtain supple gambir extract;
the preparation method of the dill leaf extracting solution comprises the following steps:
taking dill leaves, drying, crushing, sieving with a 80-mesh sieve, placing in a round-bottom flask, adding 6 times of distilled water, then adding 1% cellulase, slightly stirring, adjusting the pH to 5.0 by hydrochloric acid, placing in a constant-temperature oscillator at 45 ℃ for enzymolysis for 45min, placing in a water bath, adjusting the temperature to 80 ℃, connecting with a condensing tube for reflux extraction for 2 times, 2 hours each time, filtering, combining filtrates, concentrating, adding ethyl acetate for extraction until an extraction layer is colorless, combining extract liquor, placing in a rotary evaporator for recovering ethyl acetate, and concentrating to 0.5g/ml equivalent to crude drugs to obtain a dill leaf extract;
the preparation method of the ophiorrhiza pumila extract comprises the following steps:
taking the snakegourd, drying, crushing, sieving with a 80-mesh sieve, placing in a triangular flask with a stopper, adding 60% ethanol in an amount which is 3 times that of the snakegourd, extracting for 3 times in an ultrasonic oscillator by ultrasonic oscillation at the ultrasonic frequency of 60KHz and the temperature of 60 ℃, filtering and combining filtrates, recovering ethanol by using a rotary evaporator, and concentrating to 1.2g/ml equivalent to that of a crude drug to obtain a snakegourd extracting solution;
selecting Berchemia gambir extractive solution, Anethum graveolens extractive solution and herba Hedyotidis Diffusae extractive solution according to a certain proportion, and mixing well for use; taking 1g of chitosan, adding 1% glacial acetic acid, putting the chitosan into a 100mL volumetric flask for constant volume, uniformly mixing, swelling for 24 hours, and preparing a chitosan solution with the concentration of 1% for later use; adjusting pH of the prepared crude liquid of the extractive solution mixture to 6.0 with 1% acetic acid, placing in a beaker, adding the prepared chitosan solution (1 ml chitosan solution is added to each 10ml extractive solution), stirring well, and standing for 2 h. Transferring into clean dry centrifuge tube, centrifuging at 4000r/min for 10min, and filtering with absorbent cotton to obtain the whitening sunscreen composition.
2. The whitening sunscreen composition of claim 1, wherein the ratio of the Berchemia gambir extract, the dill leaf extract and the ophiorrhiza pumila extract is 5:2: 3.
3. The whitening sunscreen emulsion containing the whitening sunscreen composition is characterized by comprising the following raw materials in percentage by weight: the whitening and sun-protecting composition according to claim 1, which comprises 10-12% of white vaseline 3-5%, 2-6% of lanolin, 2-4% of oil-soluble vitamin E, 3-5% of glyceryl monostearate, 3-5% of dimethicone, 0.1-0.2% of propyl paraben, 0.5-1% of stearyl alcohol, 3-5% of glycerol, 1-3% of amino acid humectant, 0.2-0.5% of essence and deionized water added to 100%.
4. The whitening sunscreen emulsion containing the whitening sunscreen composition according to claim 3, wherein the preparation method comprises the following steps:
white vaseline, lanolin, oil-soluble vitamin E, glyceryl monostearate, dimethicone, propyl p-hydroxybenzoate and stearyl alcohol as oil phase, and heating to 80 deg.C in water bath to dissolve completely and form homogeneous phase; putting glycerol, amino acid humectant and deionized water as water phase on a water bath kettle, heating to 80 deg.C until completely dissolved to form homogeneous phase for use; slowly adding the oil phase into the water phase in a trickle state under continuous stirring, stirring in the same direction, and stirring for 10min at the temperature of 80 ℃; gradually cooling to about 55 deg.C under continuously stirring, adding the above extract composition into the cream matrix, stirring for 5min, adding appropriate amount of essence, and cooling to obtain whitening sunscreen emulsion containing the whitening sunscreen composition.
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| CN115778887A (en) * | 2022-12-09 | 2023-03-14 | 波顿香料股份有限公司 | Whitening and sunscreen functional composition, preparation method thereof and whitening cream |
| CN115778887B (en) * | 2022-12-09 | 2024-03-19 | 波顿香料股份有限公司 | Whitening and sun-screening efficacy composition and preparation method thereof |
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