CN115778834B - Mosquito-repellent composition and application thereof - Google Patents
Mosquito-repellent composition and application thereof Download PDFInfo
- Publication number
- CN115778834B CN115778834B CN202211622201.6A CN202211622201A CN115778834B CN 115778834 B CN115778834 B CN 115778834B CN 202211622201 A CN202211622201 A CN 202211622201A CN 115778834 B CN115778834 B CN 115778834B
- Authority
- CN
- China
- Prior art keywords
- mosquito repellent
- extract
- repellent composition
- mosquito
- composition
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
- 239000000077 insect repellent Substances 0.000 title claims abstract description 67
- 239000000203 mixture Substances 0.000 title claims abstract description 53
- 229960005233 cineole Drugs 0.000 claims abstract description 8
- 239000000284 extract Substances 0.000 claims description 32
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 claims description 27
- DNIAPMSPPWPWGF-UHFFFAOYSA-N Propylene glycol Chemical compound CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 claims description 25
- PUPZLCDOIYMWBV-UHFFFAOYSA-N (+/-)-1,3-Butanediol Chemical compound CC(O)CCO PUPZLCDOIYMWBV-UHFFFAOYSA-N 0.000 claims description 20
- WEEGYLXZBRQIMU-UHFFFAOYSA-N Eucalyptol Chemical compound C1CC2CCC1(C)OC2(C)C WEEGYLXZBRQIMU-UHFFFAOYSA-N 0.000 claims description 17
- 239000000419 plant extract Substances 0.000 claims description 17
- 229920001577 copolymer Polymers 0.000 claims description 12
- NIXOWILDQLNWCW-UHFFFAOYSA-N acrylic acid group Chemical group C(C=C)(=O)O NIXOWILDQLNWCW-UHFFFAOYSA-N 0.000 claims description 11
- 150000002148 esters Chemical class 0.000 claims description 11
- 235000019437 butane-1,3-diol Nutrition 0.000 claims description 10
- SZXQTJUDPRGNJN-UHFFFAOYSA-N dipropylene glycol Chemical compound OCCCOCCCO SZXQTJUDPRGNJN-UHFFFAOYSA-N 0.000 claims description 10
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 10
- SMZOUWXMTYCWNB-UHFFFAOYSA-N 2-(2-methoxy-5-methylphenyl)ethanamine Chemical compound COC1=CC=C(C)C=C1CCN SMZOUWXMTYCWNB-UHFFFAOYSA-N 0.000 claims description 9
- 239000004359 castor oil Substances 0.000 claims description 9
- 235000019438 castor oil Nutrition 0.000 claims description 9
- ZEMPKEQAKRGZGQ-XOQCFJPHSA-N glycerol triricinoleate Natural products CCCCCC[C@@H](O)CC=CCCCCCCCC(=O)OC[C@@H](COC(=O)CCCCCCCC=CC[C@@H](O)CCCCCC)OC(=O)CCCCCCCC=CC[C@H](O)CCCCCC ZEMPKEQAKRGZGQ-XOQCFJPHSA-N 0.000 claims description 9
- SNPLKNRPJHDVJA-ZETCQYMHSA-N D-panthenol Chemical compound OCC(C)(C)[C@@H](O)C(=O)NCCCO SNPLKNRPJHDVJA-ZETCQYMHSA-N 0.000 claims description 8
- 241001071795 Gentiana Species 0.000 claims description 7
- 229940101267 panthenol Drugs 0.000 claims description 6
- 235000020957 pantothenol Nutrition 0.000 claims description 6
- 239000011619 pantothenol Substances 0.000 claims description 6
- 241001570521 Lonicera periclymenum Species 0.000 claims description 5
- 238000002360 preparation method Methods 0.000 claims description 5
- GMSCBRSQMRDRCD-UHFFFAOYSA-N dodecyl 2-methylprop-2-enoate Chemical compound CCCCCCCCCCCCOC(=O)C(C)=C GMSCBRSQMRDRCD-UHFFFAOYSA-N 0.000 claims description 2
- 244000167230 Lonicera japonica Species 0.000 claims 1
- 235000017617 Lonicera japonica Nutrition 0.000 claims 1
- 230000000694 effects Effects 0.000 abstract description 17
- 241000255925 Diptera Species 0.000 abstract description 14
- 239000005871 repellent Substances 0.000 abstract description 14
- 230000002940 repellent Effects 0.000 abstract description 14
- LYCAIKOWRPUZTN-UHFFFAOYSA-N Ethylene glycol Chemical compound OCCO LYCAIKOWRPUZTN-UHFFFAOYSA-N 0.000 abstract description 4
- 230000001846 repelling effect Effects 0.000 abstract description 4
- 238000002474 experimental method Methods 0.000 abstract description 2
- WGCNASOHLSPBMP-UHFFFAOYSA-N hydroxyacetaldehyde Natural products OCC=O WGCNASOHLSPBMP-UHFFFAOYSA-N 0.000 abstract description 2
- 239000005445 natural material Substances 0.000 abstract description 2
- 230000000052 comparative effect Effects 0.000 description 31
- 238000012360 testing method Methods 0.000 description 26
- 210000003491 skin Anatomy 0.000 description 10
- 241000699670 Mus sp. Species 0.000 description 8
- 238000006748 scratching Methods 0.000 description 8
- 230000002393 scratching effect Effects 0.000 description 8
- 230000001139 anti-pruritic effect Effects 0.000 description 7
- 229960004063 propylene glycol Drugs 0.000 description 7
- 208000003251 Pruritus Diseases 0.000 description 6
- 235000013772 propylene glycol Nutrition 0.000 description 6
- 230000003110 anti-inflammatory effect Effects 0.000 description 5
- 239000000126 substance Substances 0.000 description 5
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 4
- 210000004209 hair Anatomy 0.000 description 4
- 230000007803 itching Effects 0.000 description 4
- -1 menthane diol Chemical class 0.000 description 4
- 238000000034 method Methods 0.000 description 4
- 238000003756 stirring Methods 0.000 description 4
- 238000003786 synthesis reaction Methods 0.000 description 4
- 241000628997 Flos Species 0.000 description 3
- 241000283973 Oryctolagus cuniculus Species 0.000 description 3
- 206010040880 Skin irritation Diseases 0.000 description 3
- 150000001412 amines Chemical class 0.000 description 3
- 230000000844 anti-bacterial effect Effects 0.000 description 3
- 238000009472 formulation Methods 0.000 description 3
- 230000007794 irritation Effects 0.000 description 3
- 230000036556 skin irritation Effects 0.000 description 3
- 231100000475 skin irritation Toxicity 0.000 description 3
- DNIAPMSPPWPWGF-GSVOUGTGSA-N (R)-(-)-Propylene glycol Chemical compound C[C@@H](O)CO DNIAPMSPPWPWGF-GSVOUGTGSA-N 0.000 description 2
- 235000004866 D-panthenol Nutrition 0.000 description 2
- 239000011703 D-panthenol Substances 0.000 description 2
- 201000004624 Dermatitis Diseases 0.000 description 2
- 239000003908 antipruritic agent Substances 0.000 description 2
- 238000013329 compounding Methods 0.000 description 2
- 229960003949 dexpanthenol Drugs 0.000 description 2
- 235000011187 glycerol Nutrition 0.000 description 2
- 239000007788 liquid Substances 0.000 description 2
- 230000003020 moisturizing effect Effects 0.000 description 2
- 231100000344 non-irritating Toxicity 0.000 description 2
- 239000002904 solvent Substances 0.000 description 2
- 230000008961 swelling Effects 0.000 description 2
- 230000002195 synergetic effect Effects 0.000 description 2
- 241000256173 Aedes albopictus Species 0.000 description 1
- 241000256059 Culex pipiens Species 0.000 description 1
- 206010012438 Dermatitis atopic Diseases 0.000 description 1
- 229920002307 Dextran Polymers 0.000 description 1
- 206010013786 Dry skin Diseases 0.000 description 1
- 241000196324 Embryophyta Species 0.000 description 1
- WEEGYLXZBRQIMU-WAAGHKOSSA-N Eucalyptol Chemical compound C1C[C@H]2CC[C@]1(C)OC2(C)C WEEGYLXZBRQIMU-WAAGHKOSSA-N 0.000 description 1
- 244000165852 Eucalyptus citriodora Species 0.000 description 1
- 235000004722 Eucalyptus citriodora Nutrition 0.000 description 1
- 241000238631 Hexapoda Species 0.000 description 1
- 206010020751 Hypersensitivity Diseases 0.000 description 1
- 206010061218 Inflammation Diseases 0.000 description 1
- ZSBXGIUJOOQZMP-UHFFFAOYSA-N Isomatrine Natural products C1CCC2CN3C(=O)CCCC3C3C2N1CCC3 ZSBXGIUJOOQZMP-UHFFFAOYSA-N 0.000 description 1
- 241000581650 Ivesia Species 0.000 description 1
- 241000245240 Lonicera Species 0.000 description 1
- ZSBXGIUJOOQZMP-JLNYLFASSA-N Matrine Chemical group C1CC[C@H]2CN3C(=O)CCC[C@@H]3[C@@H]3[C@H]2N1CCC3 ZSBXGIUJOOQZMP-JLNYLFASSA-N 0.000 description 1
- 241001465754 Metazoa Species 0.000 description 1
- 241000699666 Mus <mouse, genus> Species 0.000 description 1
- 206010070834 Sensitisation Diseases 0.000 description 1
- 239000004480 active ingredient Substances 0.000 description 1
- 208000026935 allergic disease Diseases 0.000 description 1
- 230000007815 allergy Effects 0.000 description 1
- 201000008937 atopic dermatitis Diseases 0.000 description 1
- 208000010668 atopic eczema Diseases 0.000 description 1
- 210000001142 back Anatomy 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 238000006243 chemical reaction Methods 0.000 description 1
- 239000003153 chemical reaction reagent Substances 0.000 description 1
- 239000003795 chemical substances by application Substances 0.000 description 1
- 239000002537 cosmetic Substances 0.000 description 1
- 230000007547 defect Effects 0.000 description 1
- 238000004090 dissolution Methods 0.000 description 1
- 239000012153 distilled water Substances 0.000 description 1
- LQZZUXJYWNFBMV-UHFFFAOYSA-N dodecan-1-ol Chemical compound CCCCCCCCCCCCO LQZZUXJYWNFBMV-UHFFFAOYSA-N 0.000 description 1
- 230000037336 dry skin Effects 0.000 description 1
- 210000002615 epidermis Anatomy 0.000 description 1
- 238000011156 evaluation Methods 0.000 description 1
- 229930003935 flavonoid Natural products 0.000 description 1
- 235000017173 flavonoids Nutrition 0.000 description 1
- 230000006870 function Effects 0.000 description 1
- 241000411851 herbal medicine Species 0.000 description 1
- 230000004054 inflammatory process Effects 0.000 description 1
- 230000002401 inhibitory effect Effects 0.000 description 1
- 239000002917 insecticide Substances 0.000 description 1
- 230000010354 integration Effects 0.000 description 1
- 238000010253 intravenous injection Methods 0.000 description 1
- 230000007774 longterm Effects 0.000 description 1
- 239000001370 lonicera japonica flower extract Substances 0.000 description 1
- 229940083960 lonicera japonica flower extract Drugs 0.000 description 1
- 230000014759 maintenance of location Effects 0.000 description 1
- 229930014456 matrine Natural products 0.000 description 1
- 238000002156 mixing Methods 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- LKPFBGKZCCBZDK-UHFFFAOYSA-N n-hydroxypiperidine Chemical compound ON1CCCCC1 LKPFBGKZCCBZDK-UHFFFAOYSA-N 0.000 description 1
- 239000000575 pesticide Substances 0.000 description 1
- 235000013824 polyphenols Nutrition 0.000 description 1
- 230000001681 protective effect Effects 0.000 description 1
- 239000002994 raw material Substances 0.000 description 1
- 230000004044 response Effects 0.000 description 1
- 230000008313 sensitization Effects 0.000 description 1
- 239000000243 solution Substances 0.000 description 1
- 239000007858 starting material Substances 0.000 description 1
- 238000006467 substitution reaction Methods 0.000 description 1
- 239000004094 surface-active agent Substances 0.000 description 1
- 210000004243 sweat Anatomy 0.000 description 1
- 208000024891 symptom Diseases 0.000 description 1
- 231100000331 toxic Toxicity 0.000 description 1
- 230000002588 toxic effect Effects 0.000 description 1
- 231100000419 toxicity Toxicity 0.000 description 1
- 230000001988 toxicity Effects 0.000 description 1
Classifications
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Landscapes
- Agricultural Chemicals And Associated Chemicals (AREA)
Abstract
The invention belongs to the technical field of daily necessities, and discloses a mosquito repelling composition and application thereof. The mosquito repellent composition comprises the menthyl glycol and the 1, 8-eucalyptol, and experiments show that the mosquito repellent composition has quite remarkable mosquito repellent effect and long protection time, and the used repellent component is a natural substance, so that the safety is good.
Description
Technical Field
The invention belongs to the technical field of daily necessities, and particularly relates to a mosquito repelling composition and application thereof.
Background
In summer, mosquitoes are abused, people are easy to bite by the mosquitoes during outdoor activities, and uncomfortable symptoms such as itching, redness and swelling and the like are easy to appear after the mosquitoes bite, so that huge trouble is brought to people. At present, a plurality of mosquito-repellent smearing products are widely used in the market, such as chemical synthesis repellent of the mosquito repellent amine, the hydroxypiperidine, the mosquito repellent ester and the like, because the mosquito repellent effect is obvious and the protection time is long. Although the chemical synthesis repellents all mark slight toxicity, the long-term use of the chemical synthesis repellents possibly causes corresponding toxic and side effects on human bodies, is not suitable for being compounded with other functional components, and has the defect of single function. In the existing products, some repellents using natural components exist, but the protection time of the repellents is often shorter.
With the improvement of living standard of people, people have higher requirements on repellent. The natural, safe, effective and multifunctional repellent can better meet the demands of people. The invention aims to provide a mosquito repellent composition which adopts natural components as effective mosquito repellent components and has better mosquito repellent effect, and is used for preparing mosquito repellent products.
Disclosure of Invention
The present invention aims to solve at least one of the technical problems in the prior art described above. Therefore, the invention provides a mosquito repellent composition and application thereof. Experiments show that the mosquito repellent composition has quite remarkable mosquito repellent effect and long protection time, and the used repellent component is a natural substance, so that the safety is good.
The invention provides a mosquito repellent composition which comprises a menthyl glycol and 1, 8-eucalyptol.
The mosquito repellent composition does not contain chemical synthesis mosquito repellent components such as the mosquito repellent amine, the mosquito repellent ester and the like, but takes natural components such as the menthanediol and the 1, 8-cineole as the effective mosquito repellent components. The menthane diol is mainly extracted from eucalyptus citriodora leaves, is the only mosquito repellent extracted from natural plants in five mosquito repellents recommended by EPA/CDC in the United states, is safe to human skin, has good mosquito repellent effect, and is a green and environment-friendly mosquito repellent. The 1, 8-cineole has good mosquito-repellent effect and has certain antibacterial, anti-inflammatory and antipruritic effects. The invention indicates that the repellent effect can be synergistically improved by compounding the 1, 8-eucalyptol with the menthanediol, and the itch can be relieved advantageously.
Preferably, the mass ratio of the menthanediol to the 1, 8-eucalyptol in the mosquito repellent composition is (6-60): 1.
Preferably, the mosquito repellent composition further comprises a plant extract consisting of gentian root extract, sophorae radix extract and lonicera japonica flower extract. The radix Gentianae extract has effects of inhibiting irritation and resisting inflammation, and can be used for treating atopic dermatitis and allergy. The radix Sophorae Flavescentis extract is derived from root of radix Sophorae Flavescentis, and its effective component is matrine, which is a traditional herbal medicine. Can be used for treating eczema and dermatitis, and has antibacterial and antiinflammatory effects. The polyphenol compounds and flavonoid compounds contained in the honeysuckle flower extract have antibacterial and anti-inflammatory effects, and have good sensitization resistance. After the three plant extracts are compounded, the synergistic effect can be exerted, and the three plant extracts have remarkable anti-inflammatory and antipruritic effects.
More preferably, the mass ratio of gentian extract, kuh-seng extract and honeysuckle extract in the plant extract is (1.5-2.5): (0.6-1.2): 1.
Further preferably, the mass ratio of gentian extract, kuh-seng extract and honeysuckle extract in the plant extract is 2:1:1.
Preferably, the mosquito repellent composition further comprises at least one of 1, 3-butanediol, 1, 2-propanediol, glycerol, dipropylene glycol, PEG-hydrogenated castor oil. The invention uses solvents such as 1, 3-butanediol, 1, 2-propanediol, dipropylene glycol, PEG-hydrogenated castor oil and the like except ethanol and surfactant for solvent, and has the characteristics of no ethanol and higher mildness. Meanwhile, the 1, 2-propylene glycol, the 1, 3-butanediol and the dipropylene glycol have certain moisturizing effects, and the moisturizing effects are improved through compounding with glycerol and panthenol. Panthenol can increase skin moisture, make dry skin softer and more elastic, and has antiinflammatory effect, and can relieve skin irritation.
Preferably, the mosquito repellent composition further comprises a VP/acrylic/lauryl methacrylate copolymer. The VP/acrylic acid (ester)/lauryl alcohol methacrylate copolymer has sweat and water resistance, can form a layer of good protective film on the surface of the skin, can effectively slow down volatilization of mosquito repellent components, improves the retention time of the mosquito repellent components on the surface of the skin, and prolongs the effective protection time.
Preferably, the mosquito repellent composition comprises the following components: monenediol, 1, 8-cineole, 1, 3-butanediol, glycerol, propylene glycol, PEG-hydrogenated castor oil, dipropylene glycol, VP/acrylic acid (esters) type/laurylmethacrylate copolymer, panthenol, plant extract, water;
The plant extract comprises radix Gentianae extract, radix Sophorae Flavescentis extract and flos Lonicerae extract.
More preferably, the mosquito repellent composition consists of the following components in weight percent: 7-12% of menthanediol, 0.2-1% of 1, 8-cineole, 10-15% of 1, 3-butanediol, 1-2% of glycerol, 5-10% of propylene glycol, 5-8% of PEG-hydrogenated castor oil, 15-20% of dipropylene glycol, 1-2% of VP/acrylic acid (ester) type/laurinol methacrylate copolymer, 0.1-0.5% of panthenol, 0.1-1% of plant extract and the balance of water.
The invention also provides a preparation method of the mosquito repellent composition, which comprises the following steps:
(1) Mixing VP/acrylic acid (ester) copolymer/laurylmethacrylate, glycerol and propylene glycol to obtain composition A;
(2) Adding the menthanediol, the 1, 8-eucalyptol, the dipropylene glycol, the 1, 3-butanediol, the PEG-hydrogenated castor oil and the D-panthenol into the composition A to obtain a composition B;
(3) Adding radix Gentianae extract, radix Sophorae Flavescentis extract and flos Lonicerae extract into the composition B to obtain composition C;
(4) Adding water to the composition C to obtain the mosquito repellent composition.
The invention also provides application of the mosquito repellent composition in preparation of a mosquito repellent.
The invention also provides a mosquito repellent, which comprises the mosquito repellent composition.
Compared with the prior art, the invention has the following beneficial effects:
The mosquito repellent composition provided by the invention has the characteristics of natural safety, long-acting mosquito repellent, multiple effect integration, mildness and no irritation. And the preparation method is simple and easy to produce. Not only can solve the problem of skin itch and red swelling after being bitten by mosquitoes, but also can play a good role in repelling mosquitoes and protecting, thereby better solving the problem of mosquito biting.
Detailed Description
In order to make the technical solutions of the present invention more apparent to those skilled in the art, the following examples will be presented. It should be noted that the following embodiments are only preferred embodiments of the present invention, and the scope of the present invention is not limited to the following embodiments, and any modifications, substitutions, and combinations made without departing from the spirit and principles of the present invention are included in the scope of the present invention.
The starting materials, reagents or apparatus used in the following examples are all available from conventional commercial sources or may be obtained by methods known in the art unless otherwise specified.
Examples 1 to 4
The corresponding mosquito repellent compositions (i.e., examples 1-4) were prepared according to the weight percentages of the components shown in table 1 using the following preparation method:
(1) And adding the VP/acrylic acid (ester) copolymer/lauryl methacrylate copolymer into glycerol and propylene glycol, and stirring for dissolution to obtain the composition A.
(2) Adding the menthanediol, the 1, 8-eucalyptol, the dipropylene glycol, the 1, 3-butanediol, the PEG-hydrogenated castor oil and the D-panthenol into the composition A, and stirring for 10-20min to obtain the composition B.
(3) Adding radix Gentianae extract, radix Sophorae Flavescentis extract and flos Lonicerae extract into composition B, and stirring to obtain composition C.
(4) Adding water into the composition C, and stirring to obtain the mosquito repellent composition.
Table 1 formulation tables of examples 1-4
Comparative example 1
Certain commercial 10% common mosquito repellent amine mosquito repellent liquid
Comparative examples 2 to 7
Corresponding mosquito repellent compositions (i.e., comparative examples 2-7) were prepared in a similar manner to examples 1-4, based on the weight percentages of the components shown in tables 2-3.
Table 2 formulation of comparative examples 2-4
Table 3 formulation of comparative examples 5-7
Product effect test
Test 1: skin irritation test
40 Adult, healthy and skin-friendly rabbits are divided into 10 groups of 4 rabbits each; the mosquito repellent compositions prepared in examples 1 to 4 and comparative examples 2 to 7 were each used as a test substance. The back and the spine of the rabbit are sheared off by the hairs at the two sides of the spine 24 hours before the test, the epidermis can not be damaged, the hair removal range is about 3cm multiplied by 3cm, and the smearing area is 2.5cm multiplied by 2.5cm. 0.5g of the test substance was applied to the left skin, and the right skin was coated with distilled water in an equal amount as a control. The application was performed 1 time a day for 14 days. The hair should be removed before each application, and the residual test substance should be removed with warm water from the next day. After one hour the skin irritation response was observed and the irritation was integrated and judged according to cosmetic safety specifications (2015).
The test results showed that the reaction scores of examples 1-4, comparative examples 2-7 were 0.00, which is non-irritating. The results demonstrate that examples 1-4, comparative examples 2-7 are all non-irritating, indicating good safety of the raw materials used.
Test 2: mosquito repelling effect test
Mosquito-cage biting method: the "mosquito cage bite method" was referred to as "GB-T13917.9-2009 indoor efficacy test of hygienic insecticide for pesticide registration and evaluation of part 9 repellent".
300 Aedes albopictus were prepared and released into a test mosquito cage for use, and the rubber glove was cut into square biting windows 40mm by 40mm in size. One hand was put on the glove to test the number of the biting insects in the 2min, and data were recorded, 4 challenged qualified testers were put on the rubber glove prepared in advance, a skin area of 50mm×50mm was drawn in the exposed back of the hand, samples to be tested were uniformly smeared at a dose of 1.5mg/cm 2 (examples 1-4, comparative examples 1-4), the hands were put into the mosquito cage at intervals of 2min, and the number of stopping before was recorded. After 2 hours of application, the test is started, 1 time is tested every 0.25 hour, as long as one mosquito stops before falling, the mosquito is invalid, the average protection duration is calculated, and the test result is shown in table 4.
Table 4 average guard duration
As can be seen from table 4: in comparison with comparative example 1 (a commercial 10% mosquito repellent), the repellent duration of example 1 was 0.5 hour longer than comparative example 1, indicating that the mosquito repellent composition of example 1 was superior to the commercial 10% mosquito repellent.
Comparative example 2 the complete replacement of 1, 8-cineole from example 1 to menthanediol, the comparison with example 1 shows that the duration of the repellency of comparative example 2 is reduced by 0.5 hours compared to example 1; comparative example 3 the full replacement of the menthane diol of example 1 with 1, 8-cineole was compared to example 1, the duration of the repellency of comparative example 3 was reduced by 2.5 hours compared to example 1. From this, the repellent effects of comparative example 2 and comparative example 3 are inferior to those of example 1, which shows that the combination of 1,8 eucalyptol and menthanediol has a synergistic effect for improving the mosquito repellent protection period.
Comparative example 4 the VP/acrylic acid (ester) type/lauryl methacrylate copolymer of example 1 was replaced with water, and compared with example 1, the repellent period of comparative example 4 was reduced by 0.75 hours compared with example 1, and the addition of VP/acrylic acid (ester) type/lauryl methacrylate copolymer was able to extend the mosquito repellent effective period.
Test 3: antipruritic effect test
Mouse tail intravenous injection method: using 15-20g of ICR mice as test animals, dividing 80 mice into 8 groups of 10 mice each, and dividing the mice into male and female halves; the products of examples 1 to 4, comparative example 1, comparative examples 5 to 7 were used as test substances, respectively.
The test steps are as follows: 1) The depilating agent is used to remove the dorsum hair of about 2×3cm at the back of the mouse neck 24 hours before administration, so as to ensure the skin to be intact and unbroken. 2) The local skin is applied 1 time a day from the next day of dehairing, and 0.2mL of the test object is directly applied to dehairing parts each time, so that the test object is naturally absorbed, and the application is continued for 5 days. 3) After the last administration for 1h, 0.02% dextran was intravenously injected into the tail of each group of mice, 5mL/kg was measured, the front paws of the mice were used for scratching the head, the rear paws were used for scratching the trunk, the mouth biting all parts of the whole body were used as itching indexes, the continuous scratching of the mice was used for causing short pauses, one scratching calculation was performed, and the scratching times of the mice within 30min were observed and recorded. The test results are shown in Table 5.
Table 5 antipruritic test results
| Average number of scratching for 30min | |
| Example 1 | 28.1±1.27 |
| Example 2 | 31.7±1.18 |
| Example 3 | 32.0±1.02 |
| Example 4 | 30.6±0.88 |
| Comparative example 1 | 77.5±1.29 |
| Comparative example 5 | 38.6±1.06 |
| Comparative example 6 | 41.2±1.20 |
| Comparative example 7 | 41.4±1.27 |
As can be seen from table 5: when comparative example 1 (a commercial 10% mosquito repellent liquid) was used as a test object, the number of scratching times was significantly larger than that of examples 1 to 4, indicating that the antipruritic active ingredient added in examples 1 to 4 had a good antipruritic effect.
In comparison with example 1, comparative example 5 only gentian extract, comparative example 6 only sophorae radix extract, and comparative example 7 only lonicera flower extract. The number of scratching times was significantly increased in the case of comparative examples 5 to 7 as the test substance as compared with example 1, i.e., the antipruritic effect of comparative examples 5 to 7 was inferior to that of example 1. The results show that the effect of relieving itching by adding only a single plant extract is poorer than the effect of simultaneously adding the three plant extracts under the condition that the total dosage of the plant extracts is the same, and the effect of synergy on improving the effect of relieving itching among the three plant extracts is shown.
While the embodiments of the present invention have been described in detail, the present invention is not limited to the above embodiments, and various changes can be made without departing from the spirit of the present invention within the knowledge of those skilled in the art. Furthermore, embodiments of the invention and features of the embodiments may be combined with each other without conflict.
Claims (7)
1. The mosquito repellent composition is characterized in that the mass ratio of the menthanediol to the 1, 8-eucalyptol in the mosquito repellent composition is (6-60): 1, a step of;
The mosquito repellent composition further comprises a plant extract, wherein the plant extract consists of gentian root extract, kuh-seng root extract and honeysuckle flower extract, and the mass ratio of the gentian root extract to the kuh-seng root extract to the honeysuckle flower extract is (1.5-2.5): (0.6-1.2): 1, a step of;
the mosquito repellent composition further comprises a VP/acrylic/lauryl methacrylate copolymer.
2. The mosquito repellent composition according to claim 1, wherein the mass ratio of gentian extract, sophorae radix extract and lonicera japonica extract in the plant extract is 2:1:1.
3. The mosquito repellent composition of claim 1, further comprising at least one of 1, 3-butanediol, propylene glycol, glycerol, dipropylene glycol, PEG-hydrogenated castor oil.
4. A mosquito repellent composition according to any one of claims 1 to 3, comprising the following components: monenediol, 1, 8-cineole, 1, 3-butanediol, glycerol, propylene glycol, PEG-hydrogenated castor oil, dipropylene glycol, VP/acrylic acid (ester) copolymer/laurylmethacrylate, panthenol, plant extract, and water.
5. The mosquito repellent composition of claim 4, wherein the composition consists of the following components in weight percent: 7-12% of menthanediol, 0.2-1% of 1, 8-cineole, 10-15% of 1, 3-butanediol, 1-2% of glycerol, 5-10% of propylene glycol, 5-8% of PEG-hydrogenated castor oil, 15-20% of dipropylene glycol, 1-2% of VP/acrylic acid (ester) type/laurinol methacrylate copolymer, 0.1-0.5% of panthenol, 0.1-1% of plant extract and the balance of water.
6. Use of the mosquito repellent composition of any one of claims 1 to 5 in the preparation of a mosquito repellent.
7. A mosquito repellent comprising the mosquito repellent composition of any one of claims 1 to 5.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202211622201.6A CN115778834B (en) | 2022-12-16 | 2022-12-16 | Mosquito-repellent composition and application thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202211622201.6A CN115778834B (en) | 2022-12-16 | 2022-12-16 | Mosquito-repellent composition and application thereof |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN115778834A CN115778834A (en) | 2023-03-14 |
| CN115778834B true CN115778834B (en) | 2024-08-13 |
Family
ID=85425344
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN202211622201.6A Active CN115778834B (en) | 2022-12-16 | 2022-12-16 | Mosquito-repellent composition and application thereof |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN115778834B (en) |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN111135209A (en) * | 2020-01-15 | 2020-05-12 | 新余昊洪医用科技有限公司 | Artemisia apiacea spray with effects of preventing malaria, repelling mosquitoes, relieving itching and repairing and preparation method thereof |
| CN114533619A (en) * | 2022-03-31 | 2022-05-27 | 福建省梦娇兰日用化学品有限公司 | Novel toilet water for child care and preparation method thereof |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7846464B2 (en) * | 2006-01-16 | 2010-12-07 | Darling Samuel T | Insect repellent composition |
| CN105052925A (en) * | 2015-07-31 | 2015-11-18 | 常州宁录生物科技有限公司 | Composition with mosquito repelling activity |
| CN105816362B (en) * | 2016-04-26 | 2018-09-04 | 丹东欣时代生物医药科技有限公司 | A kind of infant's mosquito-repellent liquid |
| GB2581375A (en) * | 2019-02-14 | 2020-08-19 | Neo Innova Healthcare Ltd | Insect repellent compositions and methods of use |
| CN111388383A (en) * | 2020-03-24 | 2020-07-10 | 福建省海乐威生物工程有限公司 | Cooling and itching relieving dew and preparation method thereof |
| CN112807259B (en) * | 2020-12-31 | 2023-05-19 | 乐比(广州)健康产业有限公司 | Safe and nontoxic mosquito-repellent composition and preparation method and application thereof |
| CN112931540A (en) * | 2021-02-20 | 2021-06-11 | 湖北煜韩环境科技有限公司 | Special repellent for cats and dogs and preparation method thereof |
-
2022
- 2022-12-16 CN CN202211622201.6A patent/CN115778834B/en active Active
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN111135209A (en) * | 2020-01-15 | 2020-05-12 | 新余昊洪医用科技有限公司 | Artemisia apiacea spray with effects of preventing malaria, repelling mosquitoes, relieving itching and repairing and preparation method thereof |
| CN114533619A (en) * | 2022-03-31 | 2022-05-27 | 福建省梦娇兰日用化学品有限公司 | Novel toilet water for child care and preparation method thereof |
Also Published As
| Publication number | Publication date |
|---|---|
| CN115778834A (en) | 2023-03-14 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| EP0892635B1 (en) | Cosmetic preparations containing extracts from phyllantus emblica and centella asiatica and/or bacopa monnieri | |
| US5266318A (en) | Skin therapeutic mixture containing cold-processsed aloe vera extract, with yellow sap and aloin removed | |
| CN106344437A (en) | Folium artemisiae argyi anti-mosquito lotion and preparation method thereof | |
| CN110638727B (en) | Infant hip-protecting composition and preparation method and application thereof | |
| KR20140071738A (en) | Cosmetic composition for alleviating dermatitis and skin irritation | |
| CN111529450A (en) | Deep moisturizing repair composition, skin care product and preparation method thereof | |
| CN109453094B (en) | Mosquito-repelling and itching-relieving composition and skin care product containing composition | |
| CN101780020B (en) | Cool and refreshing toilet water capable of relieving itching and expelling mosquito | |
| CN111135209A (en) | Artemisia apiacea spray with effects of preventing malaria, repelling mosquitoes, relieving itching and repairing and preparation method thereof | |
| CN114073657A (en) | Multi-effect cream for infants and preparation method thereof | |
| CN115778834B (en) | Mosquito-repellent composition and application thereof | |
| CN112315883A (en) | Skin care composition for controlling oil and removing acne and preparation and application thereof | |
| CN111329806A (en) | Allergy-relieving repair anti-inflammatory composition and preparation method thereof | |
| CN111544553B (en) | Natural plant mosquito-repelling and itching-relieving composition containing volatile oil of Tibetan schizonepeta and application of natural plant mosquito-repelling and itching-relieving composition | |
| CN112870140A (en) | Anti-allergy itching-relieving composition, skin-care gel, and preparation method and application thereof | |
| CN111632006A (en) | Mosquito-repelling spray and preparation method thereof | |
| CN112402356A (en) | Pure micro-ecological skin cooling and nursing mask containing Chinese herbal medicines | |
| NZ755876A (en) | Composition for treating rhinitis and rhinitis ointment containing the composition | |
| CN114569516B (en) | Itching relieving and inflammation diminishing composition, itching relieving and inflammation diminishing wet tissue and preparation method thereof | |
| CN111643419B (en) | Mosquito-repelling and itching-relieving floral water and preparation method thereof | |
| CN118662587A (en) | Compound blumea balsamifera tablet mosquito-repellent itching-relieving preparation and preparation method thereof | |
| Powar et al. | A review: Polyherbal antidandruff hair oil | |
| CN105726418A (en) | Shower gel with deodorization and hidroschesis functions | |
| CN110613823A (en) | Traditional Chinese medicine composition for treating beriberi and bromhidrosis, preparation method thereof and medicine containing traditional Chinese medicine composition | |
| CN117159396A (en) | Antipruritic liquid for mosquito bite |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PB01 | Publication | ||
| PB01 | Publication | ||
| SE01 | Entry into force of request for substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| GR01 | Patent grant | ||
| GR01 | Patent grant |