CN115737775A - Traditional Chinese medicine powder for treating oral ulcer - Google Patents
Traditional Chinese medicine powder for treating oral ulcer Download PDFInfo
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- CN115737775A CN115737775A CN202211583671.6A CN202211583671A CN115737775A CN 115737775 A CN115737775 A CN 115737775A CN 202211583671 A CN202211583671 A CN 202211583671A CN 115737775 A CN115737775 A CN 115737775A
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Classifications
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- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
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- Medicines Containing Plant Substances (AREA)
Abstract
The invention relates to the technical field of traditional Chinese medicinal materials, and discloses traditional Chinese medicine powder for treating dental ulcer, which comprises the following components in parts by weight: 8-10 parts of scutellaria baicalensis, 6-8 parts of gallnut, 6-8 parts of gardenia, 8-10 parts of bamboo leaves, 4-5 parts of akebia stem, 8-10 parts of glauber salt, 6-8 parts of honeysuckle, 6-8 parts of indigo naturalis powder, 4-5 parts of asarum, 4-5 parts of wrinkled gianthyssop herb, 5-7 parts of divaricate saposhnikovia root, 8-10 parts of calamus, 5-6 parts of ginger, 6-8 parts of barbed skullcap herb, 5-7 parts of lotus root powder, 4-5 parts of dried orange peel, 5-7 parts of coix seed, 4-5 parts of Chinese rose, 4-5 parts of cinnamon, 6-8 parts of bighead atractylodes rhizome, 5-7 parts of monkshood, 4-5 parts of medicated leaven, 4-5 parts of kudzuvine root, 8-10 parts of rehmannia root, 8-10 parts of Chinese angelica, 6-8 parts of bletilla striata and 5-6 parts of snake tongue with white flower. The invention has remarkable treatment effect on the oral ulcer, and can reduce swelling and relieve pain; can effectively promote ulcer healing, reduce recurrence rate, has few adverse reactions, no side effects and more prominent long-term treatment effect.
Description
Technical Field
The invention relates to the technical field of traditional Chinese medicinal materials, in particular to traditional Chinese medicine powder for treating dental ulcer.
Background
Canker sores are a self-limiting and recurrent, periodic, recurrent disease of the mucous membrane; the oral mucosa department is in the leadership of oral mucosa diseases, and the complications such as halitosis, chronic pharyngitis, constipation, lymphadenectasis and the like are common; when the ulcer is attacked, the pain of the patient is severe, the local burning pain is very obvious, the eating and the pronunciation of the patient can be influenced, great inconvenience is brought to daily life, and the ulcer has the characteristic of repeated attack, so that the drug treatment is required to be carried out in time.
Chinese patent discloses traditional Chinese medicine powder for treating oral ulcer (grant publication No. CN 101897726B), the patent technology is a secret prescription handed down from ancestors, the Chinese patent is a pure natural traditional Chinese medicine preparation, the curative effect is definite, no side effect is caused, no contraindication is caused, the Chinese patent is safe and reliable, but the treatment effect is poor, the recurrence rate is high, and further, the patient needs to take medicines frequently.
Disclosure of Invention
The invention aims to provide traditional Chinese medicine powder for treating oral ulcer, which solves the problems in the background technology.
In order to achieve the purpose, the invention provides the following technical scheme:
a traditional Chinese medicine powder for treating oral ulcer comprises the following components in parts by weight:
8-10 parts of scutellaria baicalensis, 6-8 parts of gallnut, 6-8 parts of gardenia, 8-10 parts of bamboo leaves, 4-5 parts of akebia stem, 8-10 parts of glauber salt, 6-8 parts of honeysuckle, 6-8 parts of indigo naturalis powder, 4-5 parts of asarum, 4-5 parts of wrinkled gianthyssop herb, 5-7 parts of divaricate saposhnikovia root, 8-10 parts of calamus, 5-6 parts of ginger, 6-8 parts of barbed skullcap herb, 5-7 parts of lotus root powder, 4-5 parts of dried orange peel, 5-7 parts of coix seed, 4-5 parts of Chinese rose, 4-5 parts of cinnamon, 6-8 parts of bighead atractylodes rhizome, 5-7 parts of monkshood, 4-5 parts of medicated leaven, 4-5 parts of kudzuvine root, 8-10 parts of rehmannia root, 8-10 parts of Chinese angelica, 6-8 parts of bletilla striata and 5-6 parts of snake tongue with white flower.
As a still further scheme of the invention: the components by weight portion are as follows:
8 parts of scutellaria baicalensis, 6 parts of gallnut, 6 parts of gardenia, 8 parts of bamboo leaves, 4 parts of akebia stem, 8 parts of mirabilite powder, 6 parts of honeysuckle, 6 parts of indigo naturalis powder, 4 parts of asarum, 4 parts of agastache rugosus, 5 parts of divaricate saposhnikovia root, 8 parts of calamus, 5 parts of ginger, 6 parts of barbed skullcap herb, 5 parts of lotus root starch, 4 parts of dried orange peel, 5 parts of coix seed, 4 parts of Chinese rose, 4 parts of cinnamon, 6 parts of bighead atractylodes rhizome, 5 parts of monkshood, 4 parts of medicated leaven, 4 parts of kudzuvine root, 8 parts of rehmannia root, 8 parts of Chinese angelica, 6 parts of bletilla striata and 5 parts of white flower snake tongue.
As a still further scheme of the invention: the composition in parts by weight is as follows:
10 parts of scutellaria baicalensis, 8 parts of gallnut, 8 parts of gardenia, 10 parts of bamboo leaves, 5 parts of akebia stem, 10 parts of mirabilite powder, 8 parts of honeysuckle, 8 parts of indigo naturalis powder, 5 parts of asarum, 5 parts of agastache rugosus, 7 parts of divaricate saposhnikovia root, 10 parts of calamus, 6 parts of ginger, 8 parts of barbed skullcap herb, 7 parts of lotus root starch, 5 parts of dried orange peel, 7 parts of coix seed, 5 parts of Chinese rose, 5 parts of cinnamon, 8 parts of bighead atractylodes rhizome, 7 parts of monkshood, 5 parts of medicated leaven, 5 parts of kudzuvine root, 10 parts of radix rehmanniae, 10 parts of Chinese angelica, 8 parts of bletilla striata and 6 parts of white flower snake tongue.
As a still further scheme of the invention: the preparation process comprises the following steps:
s1, respectively cleaning and drying traditional Chinese medicinal materials of scutellaria baicalensis, gallnut, gardenia, bamboo leaves, akebia stem, mirabilite powder, honeysuckle, natural indigo powder, asarum, agastache rugosus, divaricate saposhnikovia root, calamus, ginger, barbed skullcap herb, lotus root starch, dried orange peel, pearl barley, chinese rose, cinnamon, bighead atractylodes rhizome, monkshood, medicated leaven, kudzuvine root, rehmannia root, chinese angelica, bletilla striata and snake tongue with white flowers, and then crushing and sieving for later use;
s2, taking 8-10 parts of scutellaria baicalensis, 6-8 parts of gallnut, 6-8 parts of gardenia, 8-10 parts of bamboo leaves, 4-5 parts of akebia stem, 8-10 parts of glauber salt, 6-8 parts of honeysuckle, 6-8 parts of indigo naturalis, 4-5 parts of asarum, 4-5 parts of wrinkled gianthyssop, 5-7 parts of divaricate saposhnikovia root, 8-10 parts of calamus, 5-6 parts of ginger, 6-8 parts of sculellaria barbata, 5-7 parts of lotus root starch, 4-5 parts of dried orange peel, 5-7 parts of pearl barley, 4-5 parts of Chinese rose, 4-5 parts of cinnamon, 6-8 parts of bighead atractylodes rhizome, 5-7 parts of monkshood, 4-5 parts of medicated leaven, 4-5 parts of kudzuvine root, 8-10 parts of rehmannia root, 8-10 parts of Chinese angelica, 6-8 parts of bletilla and 5-6 parts of spreading hedyotis tongue, and mixing uniformly; dividing into two parts, wherein one part accounts for 80% of the total weight and is used as a raw material A; the other part accounts for 20 percent of the total weight and is the raw material B;
s3, adding the raw material A into a reaction kettle, adding 5 times of water by weight, heating, vacuum sterilizing, cooling to room temperature, adding cellulase, uniformly stirring, and carrying out enzymolysis to obtain an enzymolysis solution;
s4, adding the enzymatic hydrolysate into a reflux extraction device, adding a hydrochloric acid-ethanol solution with the weight being 10 times that of the enzymatic hydrolysate, and carrying out reflux extraction through a constant-temperature water bath to obtain a reflux liquid; cooling the reflux liquid to room temperature, performing centrifugal separation, and taking supernatant for later use; washing the filter residue with ethanol for several times, filtering, mixing the filtrate with the centrifuged supernatant, and drying under reduced pressure to obtain dry extract;
and S5, mixing the raw material B obtained in the step S2 with the dry extract obtained in the step S3, grinding, and sieving to obtain the finished product of the traditional Chinese medicine powder.
As a still further scheme of the invention: and in the step S1, the mixture is sieved by a 40-60-mesh sieve, and in the step S5, the mixture is sieved by a 150-200-mesh sieve.
As a still further scheme of the invention: the temperature of enzymolysis in the step S3 is 55-60 ℃, and the time is 1-2 h.
As a still further scheme of the invention: and in the step S4, the concentration of hydrochloric acid in the hydrochloric acid-ethanol solution is 0.001mol/L, and the concentration of ethanol is 90%.
As a still further scheme of the invention: the temperature of the water bath reflux in the step S4 is controlled to be 75-80 ℃, the time is controlled to be 60-80 min, and the extraction times are 3-4; and the rotation speed of centrifugal analysis is 3500-4000 r/min, 10-15 min, 0.45um microporous filter membrane is adopted during filtration, the temperature of reduced pressure drying is 105 +/-2 ℃, and the time is 2.5-3 h.
Compared with the prior art, the invention has the beneficial effects that:
the traditional Chinese medicine composition is prepared from scutellaria baicalensis, gallnut, gardenia, bamboo leaves, akebiaquinata, mirabilite, honeysuckle, natural indigo powder, asarum, agastache rugosus, divaricate saposhnikovia root, calamus, ginger, barbed skullcap herb, lotus root starch, dried orange peel, coix seed, chinese rose, cinnamon, bighead atractylodes rhizome, monkshood, medicated leaven, kudzuvine root, rehmannia root, chinese angelica, bletilla striata and snake tongue with obvious curative effect on oral ulcer, and can reduce swelling and relieve pain; can effectively promote the ulcer healing, reduce the recurrence rate, compare in western medicine have the laminating nature more, the adverse reaction is few, and the no side effect, the treatment long-term effect is more outstanding, has reduced the influence of disease to patient's life, and patient's acceptance is higher.
Detailed Description
Example one
In the embodiment of the invention, the traditional Chinese medicine powder for treating dental ulcer comprises the following components in parts by weight:
8 parts of scutellaria baicalensis, 6 parts of gallnut, 6 parts of gardenia, 8 parts of bamboo leaf, 4 parts of akebia stem, 8 parts of mirabilite powder, 6 parts of honeysuckle, 6 parts of indigo naturalis powder, 4 parts of asarum, 4 parts of agastache rugosus, 5 parts of divaricate saposhnikovia root, 8 parts of calamus, 5 parts of ginger, 6 parts of sculellaria barbata, 5 parts of lotus root powder, 4 parts of dried tangerine peel, 5 parts of coix seed, 4 parts of Chinese rose, 4 parts of cinnamon, 6 parts of bighead atractylodes rhizome, 5 parts of monkshood, 4 parts of medicated leaven, 4 parts of kudzuvine root, 8 parts of rehmannia root, 8 parts of Chinese angelica, 6 parts of bletilla striata and 5 parts of bittersweet tongue; the preparation process comprises the following steps:
s1, respectively cleaning and drying traditional Chinese medicinal materials of scutellaria baicalensis, gallnut, gardenia, bamboo leaves, akebia stem, mirabilite powder, honeysuckle, natural indigo powder, asarum, agastache rugosus, divaricate saposhnikovia root, calamus, ginger, barbed skullcap herb, lotus root starch, dried orange peel, pearl barley, chinese rose, cinnamon, bighead atractylodes rhizome, monkshood, medicated leaven, kudzuvine root, rehmannia root, chinese angelica, bletilla striata and snake tongue with white flowers, and then crushing and sieving for later use;
s2, uniformly mixing 8 parts of radix scutellariae, 6 parts of gallnut, 6 parts of fructus gardeniae, 8 parts of bamboo leaves, 4 parts of akebia stem, 8 parts of glauber salt, 6 parts of honeysuckle, 6 parts of indigo naturalis powder, 4 parts of asarum, 4 parts of wrinkled gianthyssop herb, 5 parts of divaricate saposhnikovia root, 8 parts of calamus, 5 parts of ginger, 6 parts of sculellaria barbata, 5 parts of lotus root starch, 4 parts of dried orange peel, 5 parts of pearl barley, 4 parts of Chinese rose, 4 parts of cinnamon, 6 parts of bighead atractylodes rhizome, 5 parts of monkshood, 4 parts of medicated leaven, 4 parts of kudzuvine root, 8 parts of rehmannia root, 8 parts of Chinese angelica, 6 parts of bletilla striata and 5 parts of snake tongue with white flower; dividing into two parts, wherein one part accounts for 80% of the total weight and is used as a raw material A; the other part accounts for 20 percent of the total weight and is the raw material B;
s3, adding the raw material A into a reaction kettle, adding 5 times of water by weight, heating for vacuum sterilization, cooling to room temperature, adding cellulase, uniformly stirring, and performing enzymolysis to obtain an enzymolysis solution;
s4, adding the enzymatic hydrolysate into a reflux extraction device, adding a hydrochloric acid-ethanol solution with the weight being 10 times that of the enzymatic hydrolysate, and carrying out reflux extraction through a constant-temperature water bath to obtain a reflux liquid; cooling the reflux liquid to room temperature, performing centrifugal separation, and taking supernatant for later use; washing the filter residue with ethanol for several times, filtering, mixing the filtrate with the centrifuged supernatant, and drying under reduced pressure to obtain dry extract;
and S5, mixing the raw material B obtained in the step S2 with the dry extract obtained in the step S3, grinding, and sieving to obtain the finished product of the traditional Chinese medicine powder.
Example two
In the embodiment of the invention, the traditional Chinese medicine powder for treating dental ulcer comprises the following components in parts by weight:
10 parts of scutellaria baicalensis, 8 parts of gallnut, 8 parts of gardenia, 10 parts of bamboo leaves, 5 parts of akebia stem, 10 parts of mirabilite powder, 8 parts of honeysuckle, 8 parts of indigo naturalis powder, 5 parts of asarum, 5 parts of agastache rugosus, 7 parts of divaricate saposhnikovia root, 10 parts of calamus, 6 parts of ginger, 8 parts of barbed skullcap herb, 7 parts of lotus root starch, 5 parts of dried orange peel, 7 parts of coix seed, 5 parts of Chinese rose, 5 parts of cinnamon, 8 parts of bighead atractylodes rhizome, 7 parts of monkshood, 5 parts of medicated leaven, 5 parts of kudzuvine root, 10 parts of radix rehmanniae, 10 parts of Chinese angelica, 8 parts of bletilla striata and 6 parts of white flower snake tongue; the preparation process comprises the following steps:
s1, respectively cleaning and drying traditional Chinese medicinal materials of scutellaria baicalensis, gallnut, gardenia, bamboo leaves, akebia stem, mirabilite powder, honeysuckle, natural indigo powder, asarum, agastache rugosus, divaricate saposhnikovia root, calamus, ginger, barbed skullcap herb, lotus root starch, dried orange peel, pearl barley, chinese rose, cinnamon, bighead atractylodes rhizome, monkshood, medicated leaven, kudzuvine root, rehmannia root, chinese angelica, bletilla striata and snake tongue with white flowers, and then crushing and sieving for later use;
s2, uniformly mixing 10 parts of radix scutellariae, 8 parts of gallnut, 8 parts of fructus gardeniae, 10 parts of bamboo leaves, 5 parts of akebia stem, 10 parts of glauber salt, 8 parts of honeysuckle, 8 parts of indigo naturalis powder, 5 parts of asarum, 5 parts of wrinkled gianthyssop herb, 7 parts of divaricate saposhnikovia root, 10 parts of calamus, 6 parts of ginger, 8 parts of sculellaria barbata, 7 parts of lotus root starch, 5 parts of dried orange peel, 7 parts of pearl barley, 5 parts of Chinese rose, 5 parts of cinnamon, 8 parts of bighead atractylodes rhizome, 7 parts of monkshood, 5 parts of medicated leaven, 5 parts of radix puerariae, 10 parts of radix rehmanniae, 10 parts of angelica, 8 parts of bletilla striata and 6 parts of spreading hedyotis tongue; dividing into two parts, wherein one part accounts for 80% of the total weight and is used as a raw material A; the other part accounts for 20 percent of the total weight and is the raw material B;
s3, adding the raw material A into a reaction kettle, adding 5 times of water by weight, heating, vacuum sterilizing, cooling to room temperature, adding cellulase, uniformly stirring, and carrying out enzymolysis to obtain an enzymolysis solution;
s4, adding the enzymatic hydrolysate into a reflux extraction device, adding a hydrochloric acid-ethanol solution with the weight being 10 times that of the enzymatic hydrolysate, and carrying out reflux extraction through a constant-temperature water bath to obtain a reflux liquid; cooling the reflux liquid to room temperature, performing centrifugal separation, and taking supernatant for later use; washing the residue with ethanol for several times, filtering, mixing the filtrate with the centrifuged supernatant, and drying under reduced pressure to obtain dry extract;
and S5, mixing the raw material B obtained in the step S2 with the dry extract obtained in the step S3, grinding, and sieving to obtain the finished product of the traditional Chinese medicine powder.
Preferably, the step S1 is carried out by a 40-60 mesh sieve, and the step S5 is carried out by a 150-200 mesh sieve.
Preferably, the temperature of enzymolysis in the step S3 is 55-60 ℃, and the time is 1-2 h.
Preferably, the hydrochloric acid concentration in the hydrochloric acid-ethanol solution in the step S4 is 0.001mol/L, and the ethanol concentration is 90%.
Preferably, the temperature of the water bath reflux in the step S4 is controlled to be 75-80 ℃, the time is controlled to be 60-80 min, and the extraction times are 3-4; and the rotation speed of centrifugal analysis is 3500-4000 r/min, 10-15 min, 0.45um microporous filter membrane is adopted during filtration, the temperature of reduced pressure drying is 105 +/-2 ℃, and the time is 2.5-3 h.
To better illustrate the technical effect of the present invention, it is illustrated by the following tests:
the traditional Chinese medicine powder prepared by the method is respectively used in the first embodiment and the second embodiment; the traditional Chinese medicine powder for treating oral ulcer disclosed by the patent net and the preparation method thereof (publication number: CN105853640A, publication number: 2016-08-17) are adopted as a first comparative example, and the traditional Chinese medicine powder for treating oral ulcer disclosed by the patent net (publication number: 2012-03-21, publication number: CN 101897726B) is adopted as a second comparative example;
for a period of time, 150 patients with intractable oral ulcers admitted to the hospital were randomly divided into 5 groups of 30 control groups, 11 men and 19 women, two groups of examples, one group of comparative examples and two groups of comparative examples; the average disease course is 4.62 years; example a group of 8 men and 21 women; the average disease course is 4.91 years; examples two groups were 13 men and 17 women; the average disease course is 5.07 years; comparative example a group of 11 men and 19 women; the average disease course is 4.83 years; comparative two groups 14 males and 16 females; the average disease course is 4.46 years; the five groups of patients show ulcers with different sizes on the lips, the bottoms of the mouths, the tongue tips and the like, wherein the size of the ulcer is 2-5 mm, and the number of the ulcers is 2-7; five patients had no significant difference in basic data and were comparable.
Control group adoptedConventional western medicine treatment, the spiromycin tablet is orally taken for 3 times a day, and 0.2g is taken each time; oral vitamin B 2 3 times a day, 5mg each time; orally taking amoxicillin 2 times a day, 0.2g each time; in the embodiment group, 1g of the traditional Chinese medicine powder prepared by the first embodiment of the invention is dipped by a disposable cotton swab and smeared on an affected part 3-5 times a day; in two groups of the embodiments, 1g of the traditional Chinese medicine powder prepared by the second embodiment of the invention is dipped by a disposable cotton swab and is applied to an affected part for melting, 3 to 5 times a day; a group of the traditional Chinese medicine powder prepared by the first comparative example is dipped with 1g of medicine by a disposable cotton swab each time and smeared on the affected part 3-5 times a day; comparative example two groups the traditional Chinese medicine powder prepared by the comparative example two of the invention is dipped with 1g of medicine by a disposable cotton swab each time and is smeared on the affected part 3-5 times a day.
And the duration of treatment in the control group, the example group, the comparative example group and the comparative example group is 1 week, light diet is kept during the treatment period, and spicy wine is forbidden.
After 1 week of administration, five groups of patients were observed for therapeutic effect, symptom elimination number and recurrence rate within 2 years; mainly observing the healing time of pain, red swelling and ulcer; the treatment effect is divided into excellent, good, common and ineffective, and is scored; wherein, the advantages are as follows: the pain is improved within 2 days of treatment, and ulcer is healed comprehensively within 3 days, namely 7 points are obtained; good: the pain can be improved within 3 days, and the ulcer can be healed within 5 days, wherein the rate is 5; in general: pain was improved within 4 days and ulcer healed within 7 days, which was divided into 3 points; and (4) invalidation: the ulcer is not healed within 7 days, and 0 point is obtained; the average score of the treatment efficacy, the number of patients with symptom elimination (unit: one), and the recurrence rate within 2 years are recorded in table 1 below.
TABLE 1 comparison of treatment status of five patients
From table 1 it can be derived: the average score, symptom eliminating number and recurrence rate of the treatment effects of the first and second groups of examples are closer to those of the control group; the average score, symptom eliminating number and recurrence rate of the treatment effects of the first example and the second example are obviously higher than those of the first comparative example and the second comparative example; further, it can be found that: the traditional Chinese medicine powder prepared by the invention has obvious curative effect on oral ulcer, and can reduce swelling and relieve pain; the ulcer healing can be effectively improved, the recurrence rate is reduced, and compared with western medicines, the Chinese medicinal composition has better fitting property, less adverse reaction, no side effect, more prominent long-term treatment effect and higher patient acceptance; and has the same treatment effect with western medicines which have obvious side effects.
The above description is only for the preferred embodiment of the present invention, but the scope of the present invention is not limited thereto, and any person skilled in the art should be considered to be within the technical scope of the present invention, and the technical solutions and the inventive concepts thereof according to the present invention are equivalent to or changed within the technical scope of the present invention.
Claims (8)
1. The traditional Chinese medicine powder for treating dental ulcer is characterized by comprising the following components in parts by weight:
8-10 parts of scutellaria baicalensis, 6-8 parts of gallnut, 6-8 parts of gardenia, 8-10 parts of bamboo leaves, 4-5 parts of akebia stem, 8-10 parts of glauber salt, 6-8 parts of honeysuckle, 6-8 parts of indigo naturalis powder, 4-5 parts of asarum, 4-5 parts of wrinkled gianthyssop herb, 5-7 parts of divaricate saposhnikovia root, 8-10 parts of calamus, 5-6 parts of ginger, 6-8 parts of barbed skullcap herb, 5-7 parts of lotus root powder, 4-5 parts of dried orange peel, 5-7 parts of coix seed, 4-5 parts of Chinese rose, 4-5 parts of cinnamon, 6-8 parts of bighead atractylodes rhizome, 5-7 parts of monkshood, 4-5 parts of medicated leaven, 4-5 parts of kudzuvine root, 8-10 parts of rehmannia root, 8-10 parts of Chinese angelica, 6-8 parts of bletilla striata and 5-6 parts of snake tongue with white flower.
2. The traditional Chinese medicine powder for treating oral ulcer according to claim 1, which is characterized by comprising the following components in parts by weight:
8 parts of scutellaria baicalensis, 6 parts of gallnut, 6 parts of gardenia, 8 parts of bamboo leaves, 4 parts of akebia stem, 8 parts of mirabilite powder, 6 parts of honeysuckle, 6 parts of indigo naturalis powder, 4 parts of asarum, 4 parts of agastache rugosus, 5 parts of divaricate saposhnikovia root, 8 parts of calamus, 5 parts of ginger, 6 parts of barbed skullcap herb, 5 parts of lotus root starch, 4 parts of dried orange peel, 5 parts of coix seed, 4 parts of Chinese rose, 4 parts of cinnamon, 6 parts of bighead atractylodes rhizome, 5 parts of monkshood, 4 parts of medicated leaven, 4 parts of kudzuvine root, 8 parts of rehmannia root, 8 parts of Chinese angelica, 6 parts of bletilla striata and 5 parts of white flower snake tongue.
3. The traditional Chinese medicine powder for treating oral ulcer according to claim 1, which is characterized by comprising the following components in parts by weight:
10 parts of scutellaria baicalensis, 8 parts of gallnut, 8 parts of gardenia, 10 parts of bamboo leaves, 5 parts of akebia stem, 10 parts of mirabilite powder, 8 parts of honeysuckle, 8 parts of indigo naturalis powder, 5 parts of asarum, 5 parts of agastache rugosus, 7 parts of divaricate saposhnikovia root, 10 parts of calamus, 6 parts of ginger, 8 parts of barbed skullcap herb, 7 parts of lotus root starch, 5 parts of dried orange peel, 7 parts of coix seed, 5 parts of Chinese rose, 5 parts of cinnamon, 8 parts of bighead atractylodes rhizome, 7 parts of monkshood, 5 parts of medicated leaven, 5 parts of kudzuvine root, 10 parts of radix rehmanniae, 10 parts of Chinese angelica, 8 parts of bletilla striata and 6 parts of white flower snake tongue.
4. The traditional Chinese medicine powder for treating oral ulcer according to claim 1, wherein the preparation process comprises the following steps:
s1, respectively cleaning and drying traditional Chinese medicinal materials of scutellaria baicalensis, gallnut, gardenia, bamboo leaves, akebia stem, mirabilite powder, honeysuckle, natural indigo powder, asarum, agastache rugosus, divaricate saposhnikovia root, calamus, ginger, barbed skullcap herb, lotus root starch, dried orange peel, pearl barley, chinese rose, cinnamon, bighead atractylodes rhizome, monkshood, medicated leaven, kudzuvine root, rehmannia root, chinese angelica, bletilla striata and snake tongue with white flowers, and then crushing and sieving for later use;
s2, taking 8-10 parts of scutellaria baicalensis, 6-8 parts of gallnut, 6-8 parts of gardenia, 8-10 parts of bamboo leaves, 4-5 parts of akebia stem, 8-10 parts of glauber salt, 6-8 parts of honeysuckle, 6-8 parts of indigo naturalis, 4-5 parts of asarum, 4-5 parts of wrinkled gianthyssop, 5-7 parts of divaricate saposhnikovia root, 8-10 parts of calamus, 5-6 parts of ginger, 6-8 parts of sculellaria barbata, 5-7 parts of lotus root starch, 4-5 parts of dried orange peel, 5-7 parts of pearl barley, 4-5 parts of Chinese rose, 4-5 parts of cinnamon, 6-8 parts of bighead atractylodes rhizome, 5-7 parts of monkshood, 4-5 parts of medicated leaven, 4-5 parts of kudzuvine root, 8-10 parts of rehmannia root, 8-10 parts of Chinese angelica, 6-8 parts of bletilla and 5-6 parts of spreading hedyotis tongue, and mixing uniformly; dividing into two parts, wherein one part accounts for 80% of the total weight and is used as a raw material A; the other part accounts for 20 percent of the total weight and is the raw material B;
s3, adding the raw material A into a reaction kettle, adding 5 times of water by weight, heating, vacuum sterilizing, cooling to room temperature, adding cellulase, uniformly stirring, and carrying out enzymolysis to obtain an enzymolysis solution;
s4, adding the enzymatic hydrolysate into a reflux extraction device, adding a hydrochloric acid-ethanol solution with the weight being 10 times that of the enzymatic hydrolysate, and carrying out reflux extraction through a constant-temperature water bath to obtain a reflux liquid; cooling the reflux liquid to room temperature, performing centrifugal separation, and taking supernatant for later use; washing the filter residue with ethanol for several times, filtering, mixing the filtrate with the centrifuged supernatant, and drying under reduced pressure to obtain dry extract;
and S5, mixing the raw material B obtained in the step S2 with the dry extract obtained in the step S3, grinding, and sieving to obtain the finished product of the traditional Chinese medicine powder.
5. The traditional Chinese medicine powder for treating oral ulcer according to claim 4, wherein the powder is sieved by a 40-60 mesh sieve in the step S1, and is sieved by a 150-200 mesh sieve in the step S5.
6. The traditional Chinese medicine powder for treating oral ulcer according to claim 4, wherein the temperature of enzymolysis in the step S3 is 55-60 ℃ and the time is 1-2 h.
7. The traditional Chinese medicine powder for treating oral ulcer of claim 4, wherein the hydrochloric acid concentration in the hydrochloric acid-ethanol solution in the step S4 is 0.001mol/L, and the ethanol concentration is 90%.
8. The traditional Chinese medicine powder for treating dental ulcer according to claim 4, wherein the temperature of water bath reflux in the step S4 is controlled to be 75-80 ℃, the time is controlled to be 60-80 min, and the extraction times are 3-4; and the rotation speed of centrifugal analysis is 3500-4000 r/min, 10-15 min, 0.45um microporous filter membrane is adopted during filtration, the temperature of reduced pressure drying is 105 +/-2 ℃, and the time is 2.5-3 h.
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Non-Patent Citations (2)
| Title |
|---|
| 王源;: "酶工程技术在中药提取中的应用", 山东中医杂志, no. 08, pages 614 - 617 * |
| 陈爱玲: "辨证治疗复发性口腔溃疡", 山西中医, no. 01, pages 33 - 34 * |
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