CN116115688A - Traditional Chinese medicine composition for treating oral mucosa diseases - Google Patents

Traditional Chinese medicine composition for treating oral mucosa diseases Download PDF

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Publication number
CN116115688A
CN116115688A CN202310101920.1A CN202310101920A CN116115688A CN 116115688 A CN116115688 A CN 116115688A CN 202310101920 A CN202310101920 A CN 202310101920A CN 116115688 A CN116115688 A CN 116115688A
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China
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chinese medicine
traditional chinese
oral mucosa
medicine composition
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CN202310101920.1A
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Chinese (zh)
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宣望东
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Liuyang City Traditional Chinese Medicine Hospital
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Liuyang City Traditional Chinese Medicine Hospital
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/80—Scrophulariaceae (Figwort family)
    • A61K36/804—Rehmannia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/56—Materials from animals other than mammals
    • A61K35/63—Arthropods
    • A61K35/64—Insects, e.g. bees, wasps or fleas
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/19—Acanthaceae (Acanthus family)
    • A61K36/195—Strobilanthes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/31—Brassicaceae or Cruciferae (Mustard family), e.g. broccoli, cabbage or kohlrabi
    • A61K36/315—Isatis, e.g. Dyer's woad
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
    • A61K36/484—Glycyrrhiza (licorice)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/70—Polygonaceae (Buckwheat family), e.g. spineflower or dock
    • A61K36/704—Polygonum, e.g. knotweed
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/73—Rosaceae (Rose family), e.g. strawberry, chokeberry, blackberry, pear or firethorn
    • A61K36/736—Prunus, e.g. plum, cherry, peach, apricot or almond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/85—Verbenaceae (Verbena family)
    • A61K36/855—Clerodendrum, e.g. glorybower
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/88—Liliopsida (monocotyledons)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
    • A61K9/006—Oral mucosa, e.g. mucoadhesive forms, sublingual droplets; Buccal patches or films; Buccal sprays
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/02—Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/30—Extraction of the material
    • A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
    • A61K2236/331—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation, decoction
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/30—Extraction of the material
    • A61K2236/39—Complex extraction schemes, e.g. fractionation or repeated extraction steps
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/50—Methods involving additional extraction steps
    • A61K2236/51—Concentration or drying of the extract, e.g. Lyophilisation, freeze-drying or spray-drying
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Abstract

The invention discloses a traditional Chinese medicine composition for treating oral mucosa diseases, which is characterized by comprising the following components in parts by weight: 24 parts of radix rehmanniae, 24 parts of raw pollen typhae, 9 parts of dark plum fruit, 9 parts of liquorice, 9 parts of gallnut and 9 parts of dyers woad leaf; the filtrate is taken after decoction and rinsed. Experimental results show that the invention can effectively promote the healing of oral mucosa; meanwhile, the gargle has the advantages of simple preparation process, wide material sources, obvious curative effect and no adverse reaction, and is a better medicament for clinically treating oral mucosa diseases.

Description

Traditional Chinese medicine composition for treating oral mucosa diseases
Technical Field
The invention relates to a traditional Chinese medicine composition for treating oral mucosa diseases.
Background
The oral mucosa diseases are various in types, but have complex etiology, and Western doctors consider that the oral mucosa diseases are mostly related to factors such as immunity, spirit, microcirculation, endocrine, infection and the like. The pathogenesis is unknown, so that the clinical physician usually supports the treatment of the disease aiming at the disease caused by the disease, and the curative effect is unstable due to the interference of different factors. In order to develop the characteristics and advantages of traditional Chinese medicine and improve the problems, it is necessary to search for corresponding economic, applicable and scientific clinical treatment means of traditional Chinese medicine.
Disclosure of Invention
In order to solve the defects, the invention aims to provide the traditional Chinese medicine composition for treating the oral mucosa diseases, and the healing of the oral mucosa is effectively promoted. In order to solve the technical problems, the invention adopts the technical scheme that the traditional Chinese medicine composition for treating oral mucosa diseases is characterized by comprising the following components in parts by weight: 24 parts of radix rehmanniae, 24 parts of raw pollen typhae, 9 parts of dark plum fruit, 9 parts of liquorice, 9 parts of gallnut and 9 parts of dyers woad leaf; the filtrate is taken after decoction and rinsed.
Preferably, the Chinese medicinal composition comprises the following medicinal components: 24g of radix rehmanniae, 24g of raw pollen typhae, 9g of dark plum fruit, 9g of liquorice, 9g of gallnut and 9g of dyers woad leaf; soaking the above six materials in 8 times of water for 30min, heating to boil, keeping slight boiling for 30min, and filtering; adding 5 times of water into the residue, decocting for two times, keeping micro-boiling for 30min, and filtering. Mixing the filtrates for 2 times, concentrating the filtrate to a concentration of 2g/mL of the original medicinal material, and packaging for use.
Further, the use method of the traditional Chinese medicine composition comprises the following steps: 3-5 mL of each gargle for 1-2 min, 4-6 times per day; no other mouthwash is used for gargling within 30min, and no food or water is taken.
The traditional Chinese medicine holds that the oral cavity and viscera of a human body can be connected through channels and collaterals, the relationship is close, most of oral diseases are related to viscera disorder, and the oral cavity can show corresponding symptoms when the viscera is diseased. Most of the oral mucosa diseases are caused by heat accumulation in heart and spleen, exogenous pathogenic heat, yin deficiency and fire excess, and the treatment principle is mainly to clear heat and reduce fire, nourish yin, diminish inflammation and relieve pain.
By adopting the technical scheme, the raw pollen typhae can reduce diarrhea, and the cold can clear heat, so that the raw pollen typhae has good effects on swelling and pain, sores of the mouth and tongue and the like caused by excessive internal heat due to yin deficiency; the radix rehmanniae is sweet and slightly bitter in taste and cold in nature, has the effects of nourishing yin, promoting the secretion of saliva or body fluid, nourishing blood and cooling blood, and has a good treatment effect on pharyngalgia caused by yin deficiency and internal heat; dark plum nature is flat, bitter and slightly astringent, enters liver, spleen, stomach, lung and large intestine meridians, can promote the production of body fluid, and has good efficacy on deficiency heat diabetes. The medicines are combined together to play the roles of clearing heat and reducing fire, nourishing yin and cooling blood. Has effects of astringing ulcer, relieving pain, promoting granulation and healing.
Is suitable for curing mucositis such as canker sore, lichen planus and the like and wounds after trauma or implantation.
The invention has the beneficial effects that the experimental result shows that the invention can effectively promote the healing of the oral mucosa; meanwhile, the gargle has the advantages of simple preparation process, wide material sources, obvious curative effect and no adverse reaction, and is a better medicament for clinically treating oral mucosa diseases.
The following detailed description of the present invention will provide further details in order to make the above-mentioned objects, features and advantages of the present invention more comprehensible. In the following description, numerous specific details are set forth in order to provide a thorough understanding of the present invention. The present invention may be embodied in many other forms than described herein and similarly modified by those skilled in the art without departing from the spirit of the invention, whereby the invention is not limited to the specific embodiments disclosed below.
Unless defined otherwise, all technical and scientific terms used herein have the same meaning as commonly understood by one of ordinary skill in the art to which this invention belongs. The terminology used herein in the description of the invention is for the purpose of describing particular embodiments only and is not intended to be limiting of the invention.
Detailed Description
The gargle of the invention is developed for 59 cases of treating oral mucosa diseases based on the traditional Chinese medicine theory and combined with years of clinical experience, has ideal treatment effect and is reported below.
1. Clinical data
1.1 general data 118 cases were all clinic and hospitalized patients from 2013 month 3 to 2014 month 3 in our hospital, and divided into 59 cases in the treatment group and the control group. Of these, 68 men and 50 women; age 12-65 years, average (35.6+ -8.1) years; the onset time is 7-15 d, and the average (11.8+/-2.3) d. The general data of the gender, age, time of onset, type of onset and the like of the two groups of patients are compared, and the difference has no statistical significance (P is more than 0.05) and has comparability.
2. Therapeutic method
2.1 treatment groups were treated with the mouthwash of the present invention. Mouthwashes were provided by the preparation house preparation. The medicine composition and the preparation method are as follows: 24g of radix rehmanniae, 24g of raw pollen typhae, 9g of dark plum fruit, 9g of liquorice, 9g of gallnut and 9g of dyers woad leaf. Decocting the above 6 materials by conventional method, soaking in 8 times of water for 30min, heating to boil, keeping slight boiling for 30min, and filtering; adding 5 times of water into the residue, decocting for two times, keeping micro-boiling for 30min, and filtering. Mixing the filtrates for 2 times, concentrating the filtrate to a concentration of 2g/mL of the original medicinal material, and packaging into a 100mL plastic light-resistant bottle, and preserving at constant temperature of 4deg.C for use. The using method comprises the following steps: 3-5 mL of each gargle, 1-2 min, no other gargle is used for gargling within 30min, no food or water is taken, and 4-6 times per day.
2.2 control group: is treated with a rehabilitation solution (produced by Hunan Kolun pharmaceutical Co., ltd., national drug standard: Z43020995, 2010-08-05). The use method is the same as that of the treatment group.
The treatment course of both groups of patients is 7d, and the treatment effect is counted after the treatment course is ended.
3. Observation of curative effect
3.1 efficacy standards refer to efficacy assessment standards made by the professional Committee for oral mucosa diseases of the China oral medical society. And (3) curing: the inflammatory reaction or pain of the oral cavity is completely relieved, and congestion, ulcer and erosion disappear; the effect is shown: most of the oral inflammatory reaction or pain is relieved, congestion, ulcer and erosion disappear; the method is effective: the oral inflammatory reaction or pain is relieved, and the areas of congestion, ulcer and erosion are reduced; invalidation: the oral inflammatory reaction or pain is unchanged or even aggravated, and congestion, ulcer and erosion are aggravated or unchanged.
And 3.2, collecting and processing data by a statistical method are carried out by special personnel in a data processing center of the hospital, so that the authenticity and scientificity of the data are ensured. The initial data is input into EXCEL (2003 edition) for logic checking and analysis, clean data is obtained and statistically analyzed by adopting a square table method, counting data is checked by adopting x, metering data is checked by adopting t, and a checking result shows that the difference is represented by P <0.05 and has statistical significance.
3.3 total effective rate of treatment results treatment group is 94.92%, control group is 83.05%, comparison between groups, difference has statistical significance. (see Table 1)
Table 1 two sets of treatment results and efficacy comparisons [ example (%)
Figure BDA0004073298430000021
The foregoing implementations are merely illustrative of the present invention and are not to be construed as limiting thereof. The invention has a plurality of alternatives or variants known in the technical field, and all fall into the protection scope of the invention without departing from the essential meaning of the invention.

Claims (3)

1. A traditional Chinese medicine composition for treating oral mucosa diseases is characterized by comprising the following components in parts by weight: 24 parts of radix rehmanniae, 24 parts of raw pollen typhae, 9 parts of dark plum fruit, 9 parts of liquorice, 9 parts of gallnut and 9 parts of dyers woad leaf; the filtrate is taken after decoction and rinsed.
2. The traditional Chinese medicine composition for treating oral mucosa diseases according to claim 1, wherein the traditional Chinese medicine composition comprises the following components in parts by weight: 24g of radix rehmanniae, 24g of raw pollen typhae, 9g of dark plum fruit, 9g of liquorice, 9g of gallnut and 9g of dyers woad leaf; soaking the above six materials in 8 times of water for 30min, heating to boil, keeping slight boiling for 30min, and filtering; adding 5 times of water into the residue, decocting for two times, keeping micro-boiling for 30min, and filtering. Mixing the filtrates for 2 times, concentrating the filtrate to a concentration of 2g/mL of the original medicinal material, and packaging for use.
3. The traditional Chinese medicine composition for treating oral mucosa diseases according to claim 2, wherein the use method of the traditional Chinese medicine composition is as follows: 3-5 mL of each gargle for 1-2 min, 4-6 times per day; no other mouthwash is used for gargling within 30min, and no food or water is taken.
CN202310101920.1A 2023-02-13 2023-02-13 Traditional Chinese medicine composition for treating oral mucosa diseases Pending CN116115688A (en)

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Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN103550744A (en) * 2013-11-07 2014-02-05 蔡圳 Pure traditional Chinese medicine preparation for dental ulcers
CN108553508A (en) * 2018-05-02 2018-09-21 杭州市第三人民医院 Three grass of oral mucositis are cured ulcer soup after a kind of prevention chemotherapy

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN103550744A (en) * 2013-11-07 2014-02-05 蔡圳 Pure traditional Chinese medicine preparation for dental ulcers
CN108553508A (en) * 2018-05-02 2018-09-21 杭州市第三人民医院 Three grass of oral mucositis are cured ulcer soup after a kind of prevention chemotherapy

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
宣望东: "敛疡含漱液治疗口腔黏膜病59例疗效观察", 湖南中医杂志, vol. 31, no. 4, pages 77 *
高峻鹰: "敛疡含漱液治疗口腔黏膜病临床效果评价", 医学食疗与健康, no. 4, pages 72 - 73 *

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