CN113521221A - Sealwort ointment traditional Chinese medicine prescription with monarch, minister, assistant and guide compatibility - Google Patents
Sealwort ointment traditional Chinese medicine prescription with monarch, minister, assistant and guide compatibility Download PDFInfo
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- 239000003814 drug Substances 0.000 title claims abstract description 90
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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- A61K36/88—Liliopsida (monocotyledons)
- A61K36/896—Liliaceae (Lily family), e.g. daylily, plantain lily, Hyacinth or narcissus
- A61K36/8969—Polygonatum (Solomon's seal)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/56—Materials from animals other than mammals
- A61K35/63—Arthropods
- A61K35/64—Insects, e.g. bees, wasps or fleas
- A61K35/644—Beeswax; Propolis; Royal jelly; Honey
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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- A61K36/18—Magnoliophyta (angiosperms)
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- A61K36/18—Magnoliophyta (angiosperms)
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- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/331—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation or decoction
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- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
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- A61K2236/50—Methods involving additional extraction steps
- A61K2236/51—Concentration or drying of the extract, e.g. Lyophilisation, freeze-drying or spray-drying
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Abstract
The invention discloses a monarch, minister, assistant and guide compatible polygonatum paste traditional Chinese medicine prescription, which relates to the technical field of medicine manufacturing and is prepared by decoction according to an ancient method to be beneficial to the health of a human body. The traditional Chinese medicine formula is prepared by selecting natural medicines and selecting rhizoma polygonati, fructus rosae laevigatae and fructus lycii for monarch, minister, assistant and guide compatibility, has the effects of tonifying kidney and strengthening spleen, is prepared by adding cortex eucommiae for monarch, minister, assistant and guide compatibility, has the effects of tonifying kidney and strengthening spleen, and is uncomfortable for intestines and stomach if people drink for a long time, and is worthy of illustration.
Description
Technical Field
The invention relates to the technical field of medicine manufacturing, in particular to a sealwort ointment traditional Chinese medicine prescription with monarch, minister, assistant and guide compatibility.
Background
Monarch, minister, assistant and guide are a compatibility method of a traditional Chinese medicine prescription, wherein monarch drugs are drugs which only aim at main diseases or main symptoms to play a main treatment role. The ministerial drugs have two meanings, namely, the drugs for assisting the monarch drugs to strengthen the effect of treating the main diseases or the main symptoms, and the drugs for playing the main treatment role aiming at important concurrent diseases or concurrent symptoms. The first is adjuvant, which is a medicine for strengthening the treatment effect or directly treating the secondary concurrent syndrome by matching with monarch and ministerial medicines, and the second layer is a medicine which can eliminate and weaken the toxicity of the monarch and ministerial medicines or inhibit the drastic property of the monarch and ministerial medicines. The third anti-adjuvant is a small amount of drugs with the property and taste opposite to those of the monarch drugs or with the action opposite to those of the monarch drugs, and can play a role in supplementing each other in treatment. The guiding drugs have two meanings, one is the guiding drugs, namely the drugs capable of guiding the drugs in the prescription to specific disease centers. The second layer is the harmonizing herbs, which can harmonize the properties of various herbs in the prescription.
Disclosure of Invention
The invention aims to provide a sealwort ointment traditional Chinese medicine prescription with monarch, minister, assistant and guide compatibility, so as to solve the problems mentioned in the background technology.
In order to solve the technical problems, the invention provides the following technical scheme: the monarch, minister, assistant and guide compatible rhizoma polygonati paste traditional Chinese medicine prescription is prepared by decocting according to an ancient method and is beneficial to the health of a human body, the monarch, minister, assistant and guide compatible rhizoma polygonati paste traditional Chinese medicine prescription raw materials are prepared by matching rhizoma polygonati, fructus rosae laevigatae, medlar, eucommia bark, radix polygoni multiflori preparata, fructus amomi and honey, and the compatibility method of the monarch, minister, assistant and guide compatible rhizoma polygonati paste traditional Chinese medicine prescription comprises the following steps:
the method comprises the following steps: selecting medicinal materials, cleaning and soaking;
step two: decocting the medicinal materials, and filtering the liquid medicine;
step three: decocting the filtrate and concentrating;
step four: cooling and collecting paste.
Further, the monarch, minister, assistant and guide compatible rhizoma polygonati paste traditional Chinese medicine prescription specifically comprises the following steps:
s1, selecting and cleaning rhizoma polygonati, fructus rosae laevigatae, medlar, eucommia ulmoides, radix polygoni multiflori preparata and fructus amomi with special traditional Chinese medicine cleaning water, and then soaking in cold water for 60 minutes, wherein the water is 3 cm above the medicinal materials;
s2, selecting a proper medicine pot, selecting the medicinal materials of the traditional Chinese medicine prescription which are required to be properly matched, putting the medicinal materials into the medicine pot, heating the medicinal materials by strong fire, slowly decocting the medicinal materials for 7 hours by slow fire after the medicinal materials are boiled, adding cold water during the process, keeping the liquid level to be 1 cm higher than the medicinal materials, and filtering the decoction for later use;
s3, decocting the step S2 for 3 times, filtering the soup for 3 times, and mixing the soup obtained in 3 times; s4, slowly decocting the mixed filtrate in the step S3 with slow fire, boiling the decoction with big fire when the decoction is concentrated to 1/5, standing and cooling, and adding a proper amount of honey at about 50 ℃ to obtain the finished product of the Chinese medicinal formula.
Further, the sealwort ointment traditional Chinese medicine prescription with monarch, minister, assistant and guide compatibility can be prepared by matching sealwort, cherokee rose fruit and medlar in the following proportion: 2 parts of rhizoma polygonati, 0.5 part of cherokee rose fruit and 0.5 part of medlar.
Further, the sealwort ointment traditional Chinese medicine prescription with monarch, minister, assistant and guide compatibility can also be prepared by compatibility of sealwort, cherokee rose fruit, medlar and eucommia bark, and the compatibility proportion is as follows: 2 parts of rhizoma polygonati, 0.5 part of cherokee rose fruit, 0.5 part of medlar and 0.5 part of eucommia bark.
Further, the sealwort ointment traditional Chinese medicine prescription with monarch, minister, assistant and guide compatibility can be further prepared by compatibility of sealwort, cherokee rose fruit, medlar, prepared fleece-flower root and amomum fruit, and the compatibility proportion is as follows: 2 parts of rhizoma polygonati, 0.5 part of cherokee rose fruit, 0.5 part of medlar, 0.8 part of prepared fleece-flower root and 0.6 part of fructus amomi.
Compared with the prior art, the invention has the following beneficial effects:
the traditional Chinese medicine formula is prepared by selecting natural medicines and selecting rhizoma polygonati, fructus rosae laevigatae and fructus lycii for monarch, minister, assistant and guide compatibility, has the effects of tonifying kidney and spleen but has little effect on strengthening waist, and further, the traditional Chinese medicine formula is prepared by adding cortex eucommiae, rhizoma polygonati, fructus rosae laevigatae and fructus lycii for monarch, minister, assistant and guide compatibility according to an ancient method, is prepared by decocting a paste formula according to an ancient method, has the effects of tonifying kidney and strengthening spleen, and is uncomfortable when people drink intestines and stomach for a long time, and is worth explaining that radix polygoni multiflori preparata and fructus amomi are added for monarch, minister, assistant and guide compatibility, has the effects of tonifying kidney and strengthening spleen, and is worthy of production, popularization and use; the compatibility of the traditional Chinese medicine prescription of the sealwort ointment with monarch, minister, assistant and guide compatibility can preserve the effective components in the raw materials, the production process is reasonable, and the preparation method is suitable for industrial production.
Detailed Description
The technical solutions in the embodiments of the present invention will be clearly and completely described below, and it is obvious that the described embodiments are only a part of the embodiments of the present invention, and not all embodiments. All other embodiments, which can be derived by a person skilled in the art from the embodiments given herein without making any creative effort, shall fall within the protection scope of the present invention.
The invention provides a technical scheme that: the monarch, minister, assistant and guide compatible polygonatum paste traditional Chinese medicine prescription is prepared by decoction according to an ancient method, is beneficial to the health of a human body, and is characterized in that: the monarch, minister, assistant and guide compatible rhizoma polygonati paste traditional Chinese medicine prescription is prepared by compatibility of rhizoma polygonati, cherokee rose fruit, medlar, eucommia bark, prepared fleece-flower root, fructus amomi and honey, and the compatibility method of the monarch, minister, assistant and guide compatible rhizoma polygonati paste traditional Chinese medicine prescription comprises the following steps:
the method comprises the following steps: selecting medicinal materials, cleaning and soaking;
step two: decocting the medicinal materials, and filtering the liquid medicine;
step three: decocting the filtrate and concentrating;
step four: cooling and collecting paste.
Example 1
According to the technical scheme, the invention provides a technical scheme, a sealwort ointment traditional Chinese medicine prescription with monarch, minister, assistant and guide compatibility, and specifically comprises the following steps:
s1, selecting 2 parts of rhizoma polygonati, 0.5 part of cherokee rose and 0.5 part of medlar as medicinal materials, cleaning the medicinal materials by special cleaning water for traditional Chinese medicines, and then soaking the medicinal materials in cold water for 60 minutes, wherein the water is 3 cm above the medicinal materials;
s2, selecting a proper medicine pot, selecting the Chinese medicinal materials to be matched, putting the Chinese medicinal materials into the medicine pot, heating with strong fire, decocting with slow fire for 7 hours after boiling, adding cold water during the period, keeping the liquid level 1 cm higher than the Chinese medicinal materials, and filtering the decoction for later use;
s3, decocting the step S2 for 3 times, filtering the soup for 3 times, and mixing the soup obtained in 3 times;
s4, slowly decocting the mixed filtrate in the step S3 with slow fire, boiling the decoction with big fire when the decoction is concentrated to 1/5, standing and cooling, and adding a proper amount of honey at about 50 ℃ to obtain the finished product of the Chinese medicinal formula.
It is worth mentioning that in the embodiment, the selected rhizoma polygonati, fructus rosae laevigatae and fructus lycii are subjected to monarch, minister, assistant and guide compatibility to form a traditional Chinese medicine prescription, so that the traditional Chinese medicine prescription has the effects of tonifying kidney and spleen, but has little effect on strengthening waist.
Example 2
On the basis of the embodiment 1, the invention also provides a technical scheme, and the sealwort ointment traditional Chinese medicine prescription with monarch, minister, assistant and guide compatibility specifically comprises the following steps:
s1, selecting 2 parts of rhizoma polygonati, 0.5 part of cherokee rose fruit, 0.5 part of medlar and 0.5 part of eucommia bark, cleaning by special cleaning water for traditional Chinese medicines, and then soaking in cold water for 60 minutes, wherein the water is 3 cm above the medicinal materials;
s2, selecting a proper medicine pot, selecting the Chinese medicinal materials to be matched, putting the Chinese medicinal materials into the medicine pot, heating with strong fire, decocting with slow fire for 7 hours after boiling, adding cold water during the period, keeping the liquid level 1 cm higher than the Chinese medicinal materials, and filtering the decoction for later use;
s3, decocting the step S2 for 3 times, filtering the soup for 3 times, and mixing the soup obtained in 3 times;
s4, slowly decocting the mixed filtrate in the step S3 with slow fire, boiling the decoction with big fire when the decoction is concentrated to 1/5, standing and cooling, and adding a proper amount of honey at about 50 ℃ to obtain the finished product of the Chinese medicinal formula.
It is worth to be noted that the difference between the embodiment 2 and the embodiment 1 is that eucommia ulmoides is added, and the added eucommia ulmoides, rhizoma polygonati, fructus rosae laevigatae and medlar are subjected to monarch, minister, assistant and guide compatibility to form a traditional Chinese medicine prescription, and the difference between the efficacy of the traditional Chinese medicine prescription and the embodiment 1 is that the ointment formula is decocted by an ancient method, and the traditional Chinese medicine prescription has uncomfortable intestines and stomach if people drink the ointment formula for a long time and tonify the kidney and strengthen the spleen.
Example 3
On the basis of the embodiment 1 and the embodiment 2, the invention also provides a technical scheme that: a monarch, minister, assistant and guide compatible rhizoma polygonati paste traditional Chinese medicine prescription specifically comprises the following steps:
s1, selecting 2 parts of rhizoma polygonati, 0.5 part of cherokee rose fruit, 0.5 part of medlar, 0.8 part of radix polygoni multiflori preparata and 0.6 part of fructus amomi, cleaning the materials by special cleaning water for traditional Chinese medicines, and then soaking the materials in cold water for 60 minutes, wherein the water is 3 cm above the materials;
s2, selecting a proper medicine pot, selecting the Chinese medicinal materials to be matched, putting the Chinese medicinal materials into the medicine pot, heating with strong fire, decocting with slow fire for 7 hours after boiling, adding cold water during the period, keeping the liquid level 1 cm higher than the Chinese medicinal materials, and filtering the decoction for later use;
s3, decocting the step S2 for 3 times, filtering the soup for 3 times, and mixing the soup obtained in 3 times;
s4, slowly decocting the mixed filtrate in the step S3 with slow fire, boiling the decoction with big fire when the decoction is concentrated to 1/5, standing and cooling, and adding a proper amount of honey at about 50 ℃ to obtain the finished product of the Chinese medicinal formula.
It should be further noted that the difference between the embodiment 3 and the embodiment 2 is that the prepared fleece flower root and the fructus amomi are added to carry out monarch, minister, assistant and guide compatibility to form a traditional Chinese medicine prescription, and the traditional Chinese medicine prescription has the effects of tonifying the kidney and strengthening the spleen, and prolonging the life after long-term drinking, and has no side effect.
Animal toxicity test of the inventive drug:
10 adult mice are selected, female and male mice are used, the weight is 200-; the experiments of the embodiment 1, the embodiment 2 and the embodiment 3 are respectively carried out, the super-dose experimental group is injected with 25 times of human dose, the normal-dose experimental group is injected with 5-6 times of human dose, the injection is carried out once every morning and evening for 30 days continuously, the administration reaction is observed every day, and the results show that the two groups of mice have normal activities and diets and the medicament has no adverse toxic or side effect;
in addition, acute toxicity test: the product is injected into the tail vein of the white mouse, the dosage of which is 3 times (calculated by the weight) of the human body, and the acute toxic reaction does not occur.
Long-term toxicity test: taking an experimental dog as an example, selecting 4 male and female dual-purpose rhizoma polygonati paste traditional Chinese medicine formulas with the weight of 40-50kg, injecting the rhizoma polygonati paste traditional Chinese medicine formulas with the monarch, minister, assistant and guide compatibility into two groups, wherein one group is an overdose experimental group, the other group is a normal amount experimental group, and the experimental dog in the normal amount experimental group is tested in the above example 1, example 2 and example 3 respectively, and the injection dosage for the experimental dog in the normal amount experimental group is 6-7 times and 30 times; the experimental dog in the super-dose experimental group is injected with 7-8 times, 50 times and 150 times of the dose (calculated according to the weight) for human, the injection is respectively carried out for 3 months and 6 months, all animals survive, no toxic reaction is caused, no pathological change of the toxic significance is caused in blood and marrow smear and visceral organ pathological section, and the medicine has no adverse side effect.
The clinical curative effect is as follows:
the sealwort ointment traditional Chinese medicine formulas with monarch, minister, assistant and guide compatibility in the embodiments 1 to 3 are respectively used by 4 batches of patients, 5 patients in each batch are used for 5-6 days, no obvious side effect is generated, the curative effect is quite good, and the treatment efficiency reaches 95%.
The traditional Chinese medicine formula is prepared by selecting natural medicines and selecting rhizoma polygonati, fructus rosae laevigatae and fructus lycii for monarch, minister, assistant and guide compatibility, has the effects of tonifying kidney and spleen but has little effect on strengthening waist, and further, the traditional Chinese medicine formula is prepared by adding cortex eucommiae, rhizoma polygonati, fructus rosae laevigatae and fructus lycii for monarch, minister, assistant and guide compatibility according to an ancient method, is prepared by decocting a paste formula according to an ancient method, has the effects of tonifying kidney and strengthening spleen, and is uncomfortable when people drink intestines and stomach for a long time, and is worth explaining that radix polygoni multiflori preparata and fructus amomi are added for monarch, minister, assistant and guide compatibility, has the effects of tonifying kidney and strengthening spleen, and is worthy of production, popularization and use; the compatibility of the traditional Chinese medicine prescription of the sealwort ointment with monarch, minister, assistant and guide compatibility can preserve the effective components in the raw materials, the production process is reasonable, and the preparation method is suitable for industrial production.
Although embodiments of the present invention have been shown and described, it will be appreciated by those skilled in the art that changes, modifications, substitutions and alterations can be made in these embodiments without departing from the principles and spirit of the invention, the scope of which is defined in the appended claims and their equivalents.
Claims (5)
1. A monarch, minister, assistant and guide compatible rhizoma polygonati paste traditional Chinese medicine prescription is prepared by decoction according to an ancient method and is beneficial to the health of a human body, and is characterized in that: the monarch, minister, assistant and guide compatible rhizoma polygonati paste traditional Chinese medicine prescription is prepared by compatibility of rhizoma polygonati, cherokee rose fruit, medlar, eucommia bark, prepared fleece-flower root, fructus amomi and honey, and the compatibility method of the monarch, minister, assistant and guide compatible rhizoma polygonati paste traditional Chinese medicine prescription comprises the following steps:
the method comprises the following steps: selecting medicinal materials, cleaning and soaking;
step two: decocting the medicinal materials, and filtering the liquid medicine;
step three: decocting the filtrate and concentrating;
step four: cooling and collecting paste.
2. The monarch, minister, assistant and guide compatible rhizoma polygonati paste traditional Chinese medicine prescription according to claim 1 is characterized in that: the monarch, minister, assistant and guide compatible rhizoma polygonati paste traditional Chinese medicine prescription specifically comprises the following steps:
s1, selecting and cleaning rhizoma polygonati, fructus rosae laevigatae, medlar, eucommia ulmoides, radix polygoni multiflori preparata and fructus amomi with special traditional Chinese medicine cleaning water, and then soaking in cold water for 60 minutes, wherein the water is 3 cm above the medicinal materials;
s2, selecting a proper medicine pot, selecting the medicinal materials of the traditional Chinese medicine prescription which are required to be properly matched, putting the medicinal materials into the medicine pot, heating the medicinal materials by strong fire, slowly decocting the medicinal materials for 7 hours by slow fire after the medicinal materials are boiled, adding cold water during the process, keeping the liquid level to be 1 cm higher than the medicinal materials, and filtering the decoction for later use;
s3, decocting the step S2 for 3 times, filtering the soup for 3 times, and mixing the soup obtained in 3 times;
s4, slowly decocting the mixed filtrate in the step S3 with slow fire, boiling the decoction with big fire when the decoction is concentrated to 1/5, standing and cooling, and adding a proper amount of honey at about 50 ℃ to obtain the finished product of the Chinese medicinal formula.
3. The monarch, minister, assistant and guide compatible rhizoma polygonati paste traditional Chinese medicine prescription according to claim 1 is characterized in that: the sealwort ointment traditional Chinese medicine prescription with monarch, minister, assistant and guide compatibility can be prepared by matching sealwort, cherokee rose fruit and medlar in the following proportion: 2 parts of rhizoma polygonati, 0.5 part of cherokee rose fruit and 0.5 part of medlar.
4. The monarch, minister, assistant and guide compatible rhizoma polygonati paste traditional Chinese medicine prescription according to claim 1 is characterized in that: the sealwort ointment traditional Chinese medicine prescription with monarch, minister, assistant and guide compatibility can also be prepared by compatibility of sealwort, cherokee rose fruit, medlar and eucommia bark, and the compatibility proportion is as follows: 2 parts of rhizoma polygonati, 0.5 part of cherokee rose fruit, 0.5 part of medlar and 0.5 part of eucommia bark.
5. The monarch, minister, assistant and guide compatible rhizoma polygonati paste traditional Chinese medicine prescription according to claim 1 is characterized in that: the sealwort ointment traditional Chinese medicine prescription with monarch, minister, assistant and guide compatibility can be further prepared by compatibility of sealwort, cherokee rose fruit, medlar, prepared fleece-flower root and amomum fruit, and the compatibility proportion is as follows: 2 parts of rhizoma polygonati, 0.5 part of cherokee rose fruit, 0.5 part of medlar, 0.8 part of prepared fleece-flower root and 0.6 part of fructus amomi.
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