CN110420265B - A Chinese medicinal composition for treating diabetes, and its preparation method - Google Patents
A Chinese medicinal composition for treating diabetes, and its preparation method Download PDFInfo
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Abstract
The invention discloses a traditional Chinese medicine composition for treating diabetes and a preparation method thereof, relates to the technical field of diabetes treatment, and solves the problem of poor compliance of the traditional Chinese medicine for reducing blood sugar.
Description
Technical Field
The invention relates to the technical field of diabetes treatment, in particular to a traditional Chinese medicine composition for treating diabetes and a preparation method thereof, which are used for treating diabetes and improving symptoms of dry mouth, polydipsia, fatigue and the like of a diabetic patient.
Background
Diabetes is known as "diabetes" or "diabetes syndrome", "thirst syndrome" and the like in traditional Chinese medical literature. Ling Shu & Wu Shi (Ling Shu & Wu Shi) states that "the weak five zang organs are good at treating diabetes" indicates that the weak five zang organs are easy to cause diabetes. The book of Lingshu Benzang (Lingshu & Benzang) <: the basic premise that the five zang organs are weak is to cause diabetes, the heart is brittle and is good at fever, the lung is brittle and is good at fever and easy to damage, the liver is brittle and is good at fever and easy to damage, the spleen is brittle and is good at fever and easy to damage, and the kidney is brittle and is good at fever and easy to damage. The "Pidan" treatise on Su Wen & Qibing (Su Wen & Qi disease): when the people feel fat and beautiful, the people must eat sweet and beautiful but much fat, the fat people feel internal heat, and the sweet people feel full of the fat, so the qi overflows and turns into diabetes. Therefore, the basic pathogenesis of diabetes mellitus in relation to the emperor's internal classic is characterized by deficiency of five internal organs, impairment of qi and yin by heat, deficiency of both qi and yin, impairment of yin involving yang, deficiency of both yin and yang over time, blood stasis due to prolonged illness, blood stasis in collaterals, chest stuffiness and pain, stroke dementia, edema, numbness and pain of limbs, blurred vision and other complications.
At present, the total number of diabetes in the world is 4.25 hundred million, the number of diabetes in China is as high as 1.14 hundred million, the diabetes is the first in the world, the incidence of diabetes of adults in China is as high as 11.6%, 15% of human blood sugar regulation is damaged, the incidence is in an ascending trend, and the diabetes outbreak in a blowout mode is an public health problem. At present, the types of western medicines for treating diabetes mellitus are various, including oral medicines and insulin preparations, and although the western medicines have obvious advantages in the aspect of reducing blood sugar, the western medicines still have defects in the aspects of improving symptoms and prognosis of patients. The traditional Chinese medicine has a long history of preventing and treating diabetes, accumulates abundant clinical experience, forms a theory, a method, a formula and a medicine system for preventing and treating diabetes, is particularly characterized in treating diabetic complications, and has the advantages that: the traditional Chinese medicine composition has the advantages of treating both manifestation and root cause of disease, integrally regulating, stable curative effect, less side effect and incomparable superiority with chemical medicines. However, the existing traditional Chinese medicine formula can not fully exert the medicine effect, so that the medicine has the effect generation ratio of only 80-85%, and the effective rate is low.
Disclosure of Invention
The invention aims to: in order to solve the problem of poor compliance of the traditional Chinese medicine for reducing blood sugar, the invention provides a traditional Chinese medicine composition for treating diabetes and a preparation method thereof.
The invention specifically adopts the following technical scheme for realizing the purpose:
a traditional Chinese medicine composition for treating diabetes comprises 2-3 parts of radix astragali, 1-2 parts of radix scrophulariae, 1-2 parts of coptis chinensis, 1-2 parts of radix puerariae, 1-2 parts of rhizoma atractylodis, 1-2 parts of radix trichosanthis, 1-2 parts of radix rehmanniae and 1-2 parts of gypsum.
A preparation method of a traditional Chinese medicine composition for treating diabetes comprises the following steps:
(1) taking the medicine: taking 2-3 parts of raw astragalus membranaceus, 1-2 parts of radix scrophulariae, 1-2 parts of coptis chinensis, 1-2 parts of radix puerariae, 1-2 parts of rhizoma atractylodis, 1-2 parts of radix trichosanthis, 1-2 parts of radix rehmanniae and 1-2 parts of gypsum;
(2) drying the medicinal materials: putting the medicinal materials obtained in the step (1) into a drying oven, sequentially laying the medicinal materials in layers, closing the oven door, drying at 60 ℃ for 24h, taking out the medicinal materials after drying, and putting the medicinal materials in a shade to cool the medicinal materials;
(3) crushing medicinal materials: starting a grinder, slowly putting the dried medicinal materials in the step (2) into the grinder, and grinding the medicinal materials into powder particles of about 80 meshes;
(4) making a pill mold: spraying a small amount of water into a pill making pot for moistening, scattering a small amount of medicinal powder, rotating the pill making pot, brushing off powder particles attached to the pot, spraying water and scattering powder, repeatedly and circularly operating, gradually increasing the powder particles, and sieving particles between a first sieve and a second sieve when the particle size is 1mm to serve as a pill mold;
(5) molding: adding water to wet the uniform pill mould screened in the step (4), dusting, rounding, and repeatedly circulating the operations to prepare pills with the diameter of about 4 mm;
(6) drying the pills: putting the pills formed in the step (5) into an oven, and drying for 24 hours at the temperature of 70-75 ℃;
(7) selecting pills: polishing the dried pills in the step (6), adding water to moisten the pills, taking out the pills after rotating in a pill making pot for 1-3 min, putting the pills into a drying box for drying, removing the pills with uneven sizes, and coating the rest pills to obtain finished pills.
Furthermore, the principle of adding a few materials for multiple times is followed when the medicinal materials are crushed in the step (3).
The invention has the following beneficial effects:
1. the astragalus and the coptis have the effect of reducing blood sugar, and the astragalus is used for tonifying middle-jiao and Qi and is used as a monarch drug; radix scrophulariae has the effects of cooling blood and nourishing yin, rhizoma coptidis has the effects of clearing heat and purging fire, and gypsum has the effects of clearing heat, relieving restlessness and quenching thirst as ministerial drugs; radix Trichosanthis has effects of promoting fluid production and quenching thirst, and radix Puerariae has effects of promoting fluid production and relieving fever as adjuvant drugs; sheng Di Huang can promote the production of body fluid and strengthen the fluid, and cang Zhu can dry dampness and strengthen the spleen. The medicines are combined to play the roles of tonifying qi and spleen, promoting the production of body fluid and quenching thirst. The traditional Chinese medicine is taken according to the symptoms, the medicinal materials are scientifically and reasonably matched, the effective rate of the obtained traditional Chinese medicine reaches 96 percent and is far higher than the total effective rate of the existing traditional Chinese medicine and western medicine formulas, the compliance of a patient to the traditional Chinese medicine is better, the treatment effect is more stable, the total improvement rate of the traditional Chinese medicine and western medicine on the dry mouth symptom of a diabetic patient reaches 99 percent, the total improvement rate of polydipsia reaches 98 percent, the total improvement rate of fatigue symptoms reaches 95 percent, the total improvement rate of gastrointestinal discomfort reaches 93 percent, and the medicine effect is very obvious.
3. The traditional Chinese medicine composition can be prepared into pills or capsules, and is more convenient for patients to use than traditional Chinese medicine decoction.
Detailed Description
In order that those skilled in the art will better understand the present invention, the following examples are provided to illustrate the present invention in further detail. The following detailed description of embodiments of the invention is not intended to limit the scope of the invention as claimed, but is merely representative of selected embodiments of the invention. All other embodiments, which can be derived by a person skilled in the art from the embodiments given herein without making any creative effort, shall fall within the protection scope of the present invention.
Example 1
The embodiment provides a traditional Chinese medicine composition for treating diabetes, which mainly comprises 2 parts of radix astragali, 1 part of radix scrophulariae, 1 part of coptis chinensis, 1 part of radix puerariae, 1 part of rhizoma atractylodis, 1 part of radix trichosanthis, 1 part of radix rehmanniae and 1 part of gypsum.
The operation steps for preparing the traditional Chinese medicine composition are as follows:
(1) taking the medicine: taking 2 parts of raw astragalus, 1 part of radix scrophulariae, 1 part of coptis, 1 part of kudzu root, 1 part of rhizoma atractylodis, 1 part of radix trichosanthis, 1 part of radix rehmanniae and 1 part of gypsum;
(2) drying the medicinal materials: putting the medicinal materials obtained in the step (1) into a drying oven, sequentially laying the medicinal materials in layers, closing the oven door, drying at 60 ℃ for 24h, taking out the medicinal materials after drying, and putting the medicinal materials in a shade to cool the medicinal materials;
(3) crushing medicinal materials: starting a grinder, slowly putting the dried medicinal materials in the step (2) into the grinder, and grinding the medicinal materials into powder particles of about 80 meshes;
(4) making a pill mold: spraying a small amount of water into a pill making pot for moistening, scattering a small amount of medicinal powder, rotating the pill making pot, brushing off powder particles attached to the pot, spraying water and scattering powder, repeatedly and circularly operating, gradually increasing the powder particles, and sieving particles between a first sieve and a second sieve when the particle size is 1mm to serve as a pill mold;
(5) molding: adding water to wet the uniform pill mould screened in the step (4), dusting, rounding, and repeatedly circulating the operations to prepare pills with the diameter of about 4 mm;
(6) drying the pills: putting the pills formed in the step (5) into an oven, and drying for 24 hours at the temperature of 70 ℃;
(7) selecting pills: polishing the dried pills in the step (6), adding water to moisten the pills, taking out the pills after rotating in a pill making pot for 3min, putting the pills into a drying box for drying, removing the pills with uneven sizes, and coating the rest pills to obtain finished pills.
Example 2
The embodiment provides a traditional Chinese medicine composition for treating diabetes, which mainly comprises 3 parts of radix astragali, 1 part of radix scrophulariae, 2 parts of coptis chinensis, 1.5 parts of radix puerariae, 2 parts of rhizoma atractylodis, 1 part of radix trichosanthis, 1.5 parts of radix rehmanniae and 2 parts of gypsum.
The operation steps for preparing the traditional Chinese medicine composition are as follows:
(1) taking the medicine: taking 3 parts of raw astragalus membranaceus, 1 part of radix scrophulariae, 2 parts of coptis chinensis, 1.5 parts of radix puerariae, 2 parts of rhizoma atractylodis, 1 part of radix trichosanthis, 1.5 parts of radix rehmanniae and 2 parts of gypsum;
the remaining steps were performed as in example one.
Example 3
The embodiment provides a traditional Chinese medicine composition for treating diabetes, which mainly comprises 2.5 parts of radix astragali, 2 parts of radix scrophulariae, 1 part of coptis chinensis, 2 parts of radix puerariae, 1.5 parts of rhizoma atractylodis, 2 parts of radix trichosanthis, 2 parts of radix rehmanniae and 1 part of gypsum.
The operation steps for preparing the traditional Chinese medicine composition are as follows:
(1) taking the medicine: taking 2.5 parts of raw astragalus, 2 parts of radix scrophulariae, 1 part of coptis, 2 parts of kudzu root, 1.5 parts of rhizoma atractylodis, 2 parts of trichosanthes root, 2 parts of radix rehmanniae and 1 part of gypsum;
the remaining steps were performed as in example one.
The application method of the prepared Chinese medicinal composition pill is oral administration, 6 pills each time, three times a day, and continuous administration for 10 days.
The traditional Chinese medicine composition prepared in the embodiments 1 to 3 is clinically applied to the department of endocrinology of Baiyin division of traditional Chinese medicine institute of Gansu province after being evaluated by the center of traditional Chinese medicine preparation of traditional Chinese medicine institute of Gansu province to have the effect of reducing blood sugar without obvious side effect, and is sampled for 50 times for type 2 diabetes patients between 2018 and 2019 in the period of 8 months, and the clinical symptom improvement condition, the safety and the blood sugar control condition of the patients are observed.
The using method comprises the following steps: the pills prepared in example 1 were orally administered, 6 pills at a time, three times a day, for one month consecutively.
Safety: the functions of liver and kidney are rechecked, the electrocardiogram is not abnormal, and the patient has no drug reaction.
The clinical symptom improvement data are as follows 1:
TABLE 1
Glycemic control data are given in table 2 below:
TABLE 2
Comparative example 1
Taking 105 g of adenophora tetraphylla, 105 g of dwarf lilyturf tuber, 70 g of rhizoma anemarrhenae, 70 g of radix rehmanniae, 70 g of dendrobium, 70 g of gypsum, 70 g of scutellaria baicalensis, 14 g of coptis chinensis, 70 g of trichosanthes root, 35 g of schisandra chinensis, 70 g of astragalus mongholicus, 70 g of moutan bark, 70 g of salvia miltiorrhiza and 21 g of liquorice. Taking 35 g of gypsum, 35 g of scutellaria baicalensis, 14 g of coptis chinensis, 35 g of trichosanthes root, 35 g of astragalus mongholicus, 35 g of moutan bark and 35 g of salvia miltiorrhiza from the medicines, and crushing the medicines into ultrafine powder by using a Beili crusher for later use; decocting the rest materials in water, decocting for 2 hr with 8 times of water for the first time, decocting for 2 hr with 6 times of water for the second time, mixing the two decoctions, filtering, and concentrating the filtrate to obtain soft extract with relative density of 1.25-1.30 (60 deg.C). Adding the superfine powder, drying, pulverizing, adding starch as adjuvant, and mixing to obtain a mixture of 50 g. Making into soft mass with 85% ethanol, sieving with 12 mesh sieve, and granulating. Drying at 60 deg.C, sieving with 20-60 mesh sieve, adding 0.3 magnesium stearate, mixing, tabletting, and coating with film coat, each tablet weight is 0.35 g, and making into 1000 tablets.
Taking 50 diabetics for oral administration 3-4 tablets once, 3 times per day, and continuously taking for three months.
Comparative example 2
Taking 2.5mg of 50 diabetic patients orally taking the western medicine glibenclamide tablet for treatment, and taking orally 30min before breakfast, lunch and supper every day for 3 months continuously.
The population ratios of the therapeutic effects of comparative examples 1 and 2 are as follows 3:
TABLE 3
| Is obviously effective | Is effective | Without obvious change | |
| Comparative example 1 | 25％ | 58.5％ | 16.5％ |
| Comparative example 2 | 25％ | 50％ | 25％ |
And (4) conclusion: according to the comparison of the data in table 2 and table 3, the total effective rate (obviously effective + effective, the same below) of the traditional Chinese medicine formula in the comparative example 1 is 83.5%, the total effective rate of the western medicine in the comparative example 2 is 75%, and the total effective rate of the formula in the example is 96%, which is obviously higher than that of the comparative example 1 and the comparative example 2, so that the drug effect of the formula of the invention is more stable.
According to table 1, the symptoms of dry mouth, polydipsia, fatigue and gastrointestinal discomfort of more than 90% of patients are improved, which shows that the formula of the invention has very remarkable curative effect.
The above description is only a preferred embodiment of the present invention, and not intended to limit the present invention, and the scope of the present invention is defined by the appended claims, and all changes that come within the meaning and range of equivalency of the specification are therefore intended to be embraced therein.
Claims (3)
1. A traditional Chinese medicine composition for treating diabetes is characterized in that: the traditional Chinese medicine composition is composed of 2-3 parts of raw astragalus membranaceus, 1-2 parts of radix scrophulariae, 1-2 parts of coptis chinensis, 1-2 parts of radix puerariae, 1-2 parts of rhizoma atractylodis, 1-2 parts of radix trichosanthis, 1-2 parts of radix rehmanniae and 1-2 parts of gypsum.
2. A preparation method of a traditional Chinese medicine composition for treating diabetes is characterized by comprising the following steps: the method comprises the following steps:
(1) taking the medicine: taking 2-3 parts of raw astragalus membranaceus, 1-2 parts of radix scrophulariae, 1-2 parts of coptis chinensis, 1-2 parts of radix puerariae, 1-2 parts of rhizoma atractylodis, 1-2 parts of radix trichosanthis, 1-2 parts of radix rehmanniae and 1-2 parts of gypsum;
(2) drying the medicinal materials: putting the medicinal materials obtained in the step (1) into a drying oven, sequentially laying the medicinal materials in layers, closing the oven door, drying at 60 ℃ for 24h, taking out the medicinal materials after drying, and putting the medicinal materials in a shade to cool the medicinal materials;
(3) crushing medicinal materials: starting a grinder, slowly putting the dried medicinal materials in the step (2) into the grinder, and grinding the medicinal materials into powder particles of about 80 meshes;
(4) making a pill mold: spraying a small amount of water into a pill making pot for moistening, scattering a small amount of medicinal powder, rotating the pill making pot, brushing off powder particles attached to the pot, spraying water and scattering powder, repeatedly and circularly operating, gradually increasing the powder particles, and sieving particles between a first sieve and a second sieve when the particle size is 1mm to serve as a pill mold;
(5) molding: adding water to wet the uniform pill mould screened in the step (4), dusting, rounding, and repeatedly circulating the operations to prepare pills with the diameter of about 4 mm;
(6) drying the pills: putting the pills formed in the step (5) into an oven, and drying for 24 hours at the temperature of 70-75 ℃;
(7) selecting pills: polishing the dried pills in the step (6), adding water to moisten the pills, taking out the pills after rotating in a pill making pot for 1-3 min, putting the pills into a drying box for drying, removing the pills with uneven sizes, and coating the rest pills to obtain finished pills.
3. The preparation method of the traditional Chinese medicine composition for treating diabetes according to claim 2, characterized in that: and (4) the principle of feeding materials for a plurality of times with less materials is followed when the medicinal materials are crushed in the step (3).
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| CN102091177A (en) * | 2011-03-16 | 2011-06-15 | 天津工业大学 | Traditional Chinese medicine health product for adjuvant therapy of diabetes |
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| CN102091177A (en) * | 2011-03-16 | 2011-06-15 | 天津工业大学 | Traditional Chinese medicine health product for adjuvant therapy of diabetes |
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