CN108969712A - A kind of mixed liquor and preparation method thereof for being used to treat canker sore based on plant extracts - Google Patents

A kind of mixed liquor and preparation method thereof for being used to treat canker sore based on plant extracts Download PDF

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Publication number
CN108969712A
CN108969712A CN201810980788.5A CN201810980788A CN108969712A CN 108969712 A CN108969712 A CN 108969712A CN 201810980788 A CN201810980788 A CN 201810980788A CN 108969712 A CN108969712 A CN 108969712A
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parts
mixed liquor
canker sore
plant extracts
preparation
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王亚波
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Danyang Western Union Biotechnology Co Ltd
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Danyang Western Union Biotechnology Co Ltd
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    • A61K36/18—Magnoliophyta (angiosperms)
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    • A61K36/185—Magnoliopsida (dicotyledons)
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    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/25—Araliaceae (Ginseng family), e.g. ivy, aralia, schefflera or tetrapanax
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    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/53—Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
    • A61K36/534—Mentha (mint)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/65—Paeoniaceae (Peony family), e.g. Chinese peony
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/71—Ranunculaceae (Buttercup family), e.g. larkspur, hepatica, hydrastis, columbine or goldenseal
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/88—Liliopsida (monocotyledons)
    • A61K36/906—Zingiberaceae (Ginger family)
    • A61K36/9062—Alpinia, e.g. red ginger or galangal
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
    • A61K9/006—Oral mucosa, e.g. mucoadhesive forms, sublingual droplets; Buccal patches or films; Buccal sprays
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/02—Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
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    • A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
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    • A61K2236/10—Preparation or pretreatment of starting material
    • A61K2236/17—Preparation or pretreatment of starting material involving drying, e.g. sun-drying or wilting
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/30—Extraction of the material
    • A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
    • A61K2236/333—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using mixed solvents, e.g. 70% EtOH

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Abstract

The invention belongs to canker sore prevention and control fields, in particular to a kind of mixed liquor and preparation method thereof for being used to treat canker sore based on plant extracts, the raw material for preparing of mixed liquor mainly includes common aneurolepidium root, flower of Panax ginseng, fructus alpiniae oxyphyllae, purslane, dried peppermint leaf, honeysuckle, cassia seed, Radix Paeoniae Alba, by each raw material mixed powder it is broken after circumfluence distillation is carried out in the aqueous solution of ethyl alcohol, it is uniformly dispersed being added in glycerine water solution after filtrate drying sufficiently, obtains the mixed liquor for applying application.

Description

A kind of mixed liquor and its preparation for being used to treat canker sore based on plant extracts Method
Technical field
The invention belongs to canker sore prevention and control field, in particular to a kind of bursting for treating oral cavity based on plant extracts Mixed liquor of ulcer and preparation method thereof.
Background technique
Canker sore is a kind of common ulcerative damages illness for betiding mucous membrane of mouth, be more common in lip inside, tongue, The positions such as tongue abdomen, cheek mucous membrane, vestibular ditch, soft palate, sharp ache when breaking-out, local cusalgia is obvious, serious person also will affect diet, It speaks, very big inconvenience is caused to daily life；It can the whole bodies disease such as concurrent chronic pharyngitis, out of strength, irritated, fever, enlargement of lymph nodes Shape.
Canker sore is the result of many factors comprehensive function comprising local trauma, infection, stress, Food, drug, malnutrition, hormonal readiness changes and vitamin or microelement deficiencies etc..Such as lack trace element zinc, iron, A possibility that lacking folic acid, vitamin B etc., immune function can be reduced, increasing canker sore morbidity；Streptococcus sanguis and helicobacter pylorus The bacteriums such as bacterium are also in close relations with the generation of canker sore.The rhythm of life of modern is fast, and the job and life stress faced is very big, In addition diet and daily schedule is irregular, and the case of canker sore is caused to increase.
Summary of the invention
The pain and inconvenience for more efficient cured canker sore, reduce patient, the present invention provides one kind to be based on plant The mixed liquor for being used to treat canker sore of extract, prepare raw material includes in parts by weight,
25~50 parts of common aneurolepidium root, 25~40 parts of flower of Panax ginseng, 7~15 parts of fructus alpiniae oxyphyllae, 10~20 parts of purslane (all herbal medicine), 20~45 parts of dried peppermint leaf, 5~15 parts of honeysuckle, 8~20 parts of cassia seed, 5~10 parts of Radix Paeoniae Alba,
The preparation method comprises the following steps:
(1) each component is mixed sufficiently, and is sufficiently cleaned, dried, is crushed,
Wherein, dry operation is to be dried in vacuo at 70~75 DEG C sufficiently,
It is crushed to 30~60 mesh；
(2) smashed mixture in step (1) is added in the aqueous solution of ethyl alcohol and carries out circumfluence distillation, filtered, Filtrate is collected, filtrate is concentrated and dried, mixed extract is obtained,
Mass ratio between smashed mixture and the aqueous solution of ethyl alcohol is 1:5~8,
In the aqueous solution of ethyl alcohol, the volume ratio of ethyl alcohol and water is 2~3:1,
Circumfluence distillation duration is 45~70 minutes,
The filtrate of collection is concentrated into paste and is freeze-dried；
(3) mixed extract obtained in step (2) is added in glycerine water solution and is uniformly dispersed, obtained for controlling The mixed liquor of canker sore is treated,
Wherein, the mass ratio between mixed extract and glycerine water solution is 1:3~5,
In glycerine water solution, the volume ratio of glycerol and water is 2~3:1.
The beneficial effects of the present invention are: by the synergistic effect between multicomponent, play rapid healing canker sore The effect of, and be largely natural extract, Small side effects in mixed liquor；Preparation method is simple, operability is stronger, is suitble to work Industry metaplasia produces.
Specific embodiment
Embodiment 1
A kind of mixed liquor for being used to treat canker sore based on plant extracts, prepares raw material in parts by weight Including,
40 parts of common aneurolepidium root, 32 parts of flower of Panax ginseng, 10 parts of fructus alpiniae oxyphyllae, 15 parts of purslane (all herbal medicine), 40 parts of dried peppermint leaf, gold and silver Spend 8 parts, 13 parts of cassia seed, 6 parts of Radix Paeoniae Alba；
(1) cleaned up after being sufficiently mixed each raw material of the present embodiment according to the ratio, and by mixture at 70 DEG C vacuum It is dry abundant, then it is crushed to 40 mesh；
(2) smashed mixture in step (1) is added to circumfluence distillation 50 minutes, mistake in the aqueous solution of ethyl alcohol Gained filtrate is concentrated into paste and is freeze-dried sufficiently, obtains mixed extract by filter,
Mass ratio between smashed mixture and the aqueous solution of ethyl alcohol is 1:6.5,
In the aqueous solution of ethyl alcohol, the volume ratio of ethyl alcohol and water is 2:1；
(3) it is added in glycerine water solution and is dispersed with stirring after crushing mixed extract obtained in step (2) sufficiently Uniformly, wherein mass ratio between mixed extract and glycerine water solution is 1:3, in glycerine water solution, the volume of glycerol and water Than for 2.5:1.
Embodiment 2
A kind of mixed liquor for being used to treat canker sore based on plant extracts, prepares raw material in parts by weight Including,
36 parts of common aneurolepidium root, 30 parts of flower of Panax ginseng, 8 parts of fructus alpiniae oxyphyllae, 12 parts of purslane (all herbal medicine), 40 parts of dried peppermint leaf, gold and silver Spend 12 parts, 16 parts of cassia seed, 10 parts of Radix Paeoniae Alba；
(1) cleaned up after being sufficiently mixed each raw material of the present embodiment according to the ratio, and by mixture at 75 DEG C vacuum It is dry abundant, then it is crushed to 30 mesh；
(2) smashed mixture in step (1) is added to circumfluence distillation 60 minutes, mistake in the aqueous solution of ethyl alcohol Gained filtrate is concentrated into paste and is freeze-dried sufficiently, obtains mixed extract by filter,
Mass ratio between smashed mixture and the aqueous solution of ethyl alcohol is 1:8,
In the aqueous solution of ethyl alcohol, the volume ratio of ethyl alcohol and water is 2:1；
(3) it is added in glycerine water solution and is dispersed with stirring after crushing mixed extract obtained in step (2) sufficiently Uniformly, wherein mass ratio between mixed extract and glycerine water solution is 1:3, in glycerine water solution, the volume of glycerol and water Than for 3:1.
Comparative example 1
Common aneurolepidium root is free of in raw material, remaining component and preparation process are with embodiment 1:
Prepare raw material includes: in parts by weight
32 parts of flower of Panax ginseng, 10 parts of fructus alpiniae oxyphyllae, 15 parts of purslane (all herbal medicine), 40 parts of dried peppermint leaf, 8 parts of honeysuckle, Cassia 13 parts, 6 parts of Radix Paeoniae Alba of son.
Comparative example 2
Flower of Panax ginseng is free of in raw material, remaining component and preparation process are with embodiment 1:
Prepare raw material includes: in parts by weight
40 parts of common aneurolepidium root, 10 parts of fructus alpiniae oxyphyllae, 15 parts of purslane (all herbal medicine), 40 parts of dried peppermint leaf, 8 parts of honeysuckle, Cassia 13 parts, 6 parts of Radix Paeoniae Alba of son.
Comparative example 3
Common aneurolepidium root and flower of Panax ginseng are free of in raw material, remaining component and preparation process are with embodiment 1:
Prepare raw material includes: in parts by weight
10 parts of fructus alpiniae oxyphyllae, 15 parts of purslane (all herbal medicine), 40 parts of dried peppermint leaf, 8 parts of honeysuckle, 13 parts of cassia seed, Radix Paeoniae Alba 6 Part.
Canker sore patient, which is diagnosed as, by 120 is divided into 6 groups, this 120 patients had canker sore medical history in the past, But without other systems disease, wherein male 60, women 60, the age between 25 to 50 one full year of life, every group of 20 people after grouping There is the portion of ulcer in the passive protective physical fitness, mouth between group and group about patient age, usually in (10 males, 10 women) Position, the size of ulcer surface, ulcer quantity etc. are distributed upper no significant difference in personnel amount, by the use for recording each patient Medicine situation and recovery situation carry out the comparison between each group, and during medication, each patient works as usual, learns The social activitieies such as habit,
The mixed liquor of first group of application above embodiments 1,
The mixed liquor of second group of application above embodiments 2,
The mixed liquor of the above comparative example 1 of third group application,
The mixed liquor of the 4th group of above comparative example 2 of application,
The mixed liquor of the 5th group of above comparative example 3 of application,
6th group does not carry out pharmaceutical intervention then, allows ulcer self-healing, therefore as a control group,
Patient in the first to five group is when feeling that it is (general to burst when feeling pain that feeling of pain initially occurs in ulcer spot Also can have red and swollen phenomenon around ulcer face) when start application mixed liquor, in order to avoid other possible infection, using clean Cotton swab picks suitable mixed liquor and is applied to oral ulcer surface and peripheral part (each patient is basic one on the relative usage of mixed liquor Cause), it is silent after coating, it does not gargle, drink water or feeds, until patient oneself fundamental sensation is less than also there are mixed liquor tastes in oral cavity Until road, daily three times (morning early after meal, after lunch, before sleeping) according to the operation topical application of drug, until ulcer wound surface heal substantially, Until without red and swollen, without pain, representing healing, (" relative usage " mentioned in this paragraph indicates: ulcer surface is big, then mixed liquor applies much It is some；Ulcer surface is small, then mixed liquor applies few),
Table 1 has recorded in each group, and patient occurs pain from initial feel to ulcer spot and feels ulcer recovery from illness institute's topical application of drug Number of the number within 6 times:
Table 1
First group Second group Third group 4th group 5th group
20 people 19 people 1 people 0 people 1 people
Table 2 has recorded in each group, and patient occurs pain from initial feel to ulcer spot and feels ulcer recovery from illness institute's topical application of drug Number of the number within 6~9 times:
Table 2
First group Second group Third group 4th group 5th group
0 people 1 people 1 people 1 people 0 people
Table 3 has recorded in each group, and patient occurs pain from initial feel to ulcer spot and feels ulcer recovery from illness institute's topical application of drug Number of the number within 9~12 times:
Table 3
First group Second group Third group 4th group 5th group
0 people 0 people 8 people 10 people 7 people
Table 4 has recorded in each group, and patient occurs pain from initial feel to ulcer spot and feels ulcer recovery from illness institute's topical application of drug Number of the number within 12~15 times:
Table 4
First group Second group Third group 4th group 5th group
0 people 0 people 9 people 8 people 11 people
Table 5 has recorded in the 6th group (control group), and patient occurs pain from initial feel to ulcer spot and feels ulcer certainly Patient numbers corresponding to number of days more experienced:
Table 5
1~4 day 5 days 6 days 7~8 days 9~11 days 13 days
0 people 2 people 5 people 9 people 3 people 1 people

Claims (9)

1. a kind of mixed liquor for being used to treat canker sore based on plant extracts, it is characterised in that: the system of the mixed liquor Include in parts by weight for raw material,
25~50 parts of common aneurolepidium root, 25~40 parts of flower of Panax ginseng, 7~15 parts of fructus alpiniae oxyphyllae, 10~20 parts of purslane, dried peppermint leaf 20~45 Part, 5~15 parts of honeysuckle, 8~20 parts of cassia seed, 5~10 parts of Radix Paeoniae Alba.
2. the mixed liquor for being used to treat canker sore based on plant extracts as described in claim 1, it is characterised in that: institute The raw material for preparing for stating mixed liquor includes in parts by weight,
36~40 parts of common aneurolepidium root, 30~32 parts of flower of Panax ginseng, 8~10 parts of fructus alpiniae oxyphyllae, 12~15 parts of purslane, 40 parts of dried peppermint leaf, gold 8~12 parts of honeysuckle flower, 13~16 parts of cassia seed, 6~10 parts of Radix Paeoniae Alba.
3. a kind of preparation of the mixed liquor for treating canker sore based on plant extracts as claimed in claim 1 or 2 Method, it is characterised in that: the preparation method is,
(1) each raw material is mixed sufficiently, then sufficiently cleans, is dry, crushes；
(2) smashed mixture in step (1) is added in the aqueous solution of ethyl alcohol and carries out circumfluence distillation, filtered, collected Filtrate is concentrated and dried the filtrate, obtains mixed extract；
(3) mixed extract obtained in step (2) is added in glycerine water solution and is uniformly dispersed, obtain the mixing Liquid.
4. the preparation method of the mixed liquor for treating canker sore based on plant extracts as claimed in claim 3, Be characterized in that: in step (1), the concrete operations of the drying are to be dried in vacuo at 70~75 DEG C abundant.
5. the preparation method of the mixed liquor for treating canker sore based on plant extracts as claimed in claim 3, Be characterized in that: in step (2), the mass ratio between smashed mixture and the aqueous solution of ethyl alcohol is 1:5~8.
6. the preparation method of the mixed liquor for treating canker sore based on plant extracts as claimed in claim 3, Be characterized in that: in step (2), circumfluence distillation duration is 45~70 minutes.
7. the preparation method of the mixed liquor for treating canker sore based on plant extracts as claimed in claim 3, Be characterized in that: in step (3), the mass ratio between mixed extract and glycerine water solution is 1:3~5.
8. the preparation method of the mixed liquor for treating canker sore based on plant extracts as claimed in claim 3, Be characterized in that: in glycerine water solution described in step (3), the volume ratio of glycerol and water is 2~3:1.
9. a kind of application of the mixed liquor for treating canker sore based on plant extracts as claimed in claim 1 or 2, It is characterized by: the application is external application, i.e., the mixed liquor is coated in the peripheral portion of oral ulcer surface and ulcer surface Position.
CN201810980788.5A 2018-08-27 2018-08-27 A kind of mixed liquor and preparation method thereof for being used to treat canker sore based on plant extracts Pending CN108969712A (en)

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Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN103340267A (en) * 2013-07-19 2013-10-09 苏州市天灵中药饮片有限公司 Chinese herbal medicine herba tea and preparation method thereof
CN103392887A (en) * 2013-08-19 2013-11-20 湖北神农本草中药饮片有限公司 Honeysuckle health care tea
CN105343816A (en) * 2015-11-06 2016-02-24 王方玉 Oral ulcer treating spray for pregnant women and preparation method of oral ulcer treating spray

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN103340267A (en) * 2013-07-19 2013-10-09 苏州市天灵中药饮片有限公司 Chinese herbal medicine herba tea and preparation method thereof
CN103392887A (en) * 2013-08-19 2013-11-20 湖北神农本草中药饮片有限公司 Honeysuckle health care tea
CN105343816A (en) * 2015-11-06 2016-02-24 王方玉 Oral ulcer treating spray for pregnant women and preparation method of oral ulcer treating spray

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Application publication date: 20181211