CN1045535C

CN1045535C - Xifengdingjian pill capable of calming endopathic wind and alleviating epilepsy

Info

Publication number: CN1045535C
Application number: CN92113385A
Authority: CN
Inventors: 高永汉
Original assignee: Individual
Current assignee: Individual
Priority date: 1992-11-23
Filing date: 1992-11-23
Publication date: 1999-10-13
Anticipated expiration: 2007-11-23
Also published as: CN1087266A

Abstract

The present invention discloses a pill capable of calming endopathic wind and alleviating epilepsy for treating epilepsy, which belongs to a Chinese patent medicine for treating epilepsy. The pill is prepared from the medicines of 4.76% of bile arisaema, 1.93% of gastrodia tuber, 4.76% of processed pinellia tuber, 4.76% of earthworm, 4.76% of slender dutchmanspipe root, 4.76% of cablin patchouli herb, 4.76% of dried tangerine peel, 3.81% of tabasheer, 4.76% of chiese eaglewood wood, 4.76% of Sichuan fritillary bulb, 2.38% of raw rhubarb, 7.14% of calcined chlorite schist, 1.43% of alum, 5.72% of scorpion, 4.76% of uncaria, 2.38% of grassleaf sweetflag rhizome, 4.76% of pumice, 7.14% of borneol, 4.76% of amber powder, 2.86% of ginger juice, 3.33% of pharbitis seed, 4.76% of white peony root apharbitis seed and 4.76% of bupleurum root. After being cleaned, selected and processed, the medicines are mixed proportionally and pulverized into powder; then, the powder is sieved, stir-fried with honey and prepared into the pill.

Description

Xifengdingjian pill capable of calming endopathic wind and alleviating epilepsy

The present invention relates to a kind of manufacture method for the treatment of the pill of epileptics, belong to the manufacture method of the Chinese patent medicine for the treatment of epileptics.

At present the treatment epileptics is main is to take medicines such as Western medicine phenytoin Sodium, carbamazepine, mainly is to be used for calmly decide epilepsy and mitigate the disease can not effect a radical cure, and cures the back and easily recurs.

The objective of the invention is to overcome the deficiencies in the prior art part and provide a kind of safety range big, no side effects, late result is good, is difficult for a kind of manufacture method for the treatment of the pill of epileptics of recurrence after the drug withdrawal.

The object of the present invention is achieved like this: each percentage composition (weight) is respectively Arisaema Cum Bile 4.66-4.86%, Rhizoma Gastrodiae, 1.83-2.03%, Rhizoma Pinelliae Preparatum 4.76-4.81%, Pheretima 4.66-4.86%, Radix Aristolochiae 4.66-4.86%, Herba Pogostemonis 4.66-4.86%, Pericarpium Citri Reticulatae 4.66-4.86%, Concretio Silicea Bambusae 3.713.91%, Lignum Aquilariae Resinatum 4.66-4.86%, Bulbus Fritillariae Cirrhosae 4.66-4.86%, Radix Et Rhizoma Rhei 2.33-2.43%, forge Lapis Chloriti 7.04-7.24%, Alumen 1.33-1.53%, Scorpio 5.60-5.77%, Ramulus Uncariae Cum Uncis 4.66-4.86%, Rhizoma Acori Graminei 2.28-2.48%, Pumex 4.66-4.86%, Borneolum Syntheticum 7.04-7.24%, Succinum powder 4.66-4.86%, Sucus Zingberis 2.76-2.96%, Semen Pharbitidis 3.28-3.38%, Radix Paeoniae Alba 4.66-4.86%, Radix Bupleuri 4.66-4.86%, earlier with each flavor medicine after cleaning the roguing big gun and processing, press as above mixed, pulverize, sieve (100 mesh sieve), add in powder then that honey is mixed into sticking together of soft or hard appropriateness in the refining, in the refining close addition be medicated powder 1-1.4 doubly, stick together through branch, operations such as rubbing pelleting make finished product, and every ball weighs 9 grams.

The best proportioning (weight) of each component: Arisaema Cum Bile 4.76%, Rhizoma Gastrodiae 1.93%, Rhizoma Pinelliae Preparatum 4.76%, Pheretima 4.76%, Radix Aristolochiae 4.76%, Herba Pogostemonis 4.76%, Pericarpium Citri Reticulatae 4.76%, Concretio Silicea Bambusae 3.81%, Lignum Aquilariae Resinatum 4.76%, Bulbus Fritillariae Cirrhosae 4.76%, Radix Et Rhizoma Rhei 2.38% is forged Lapis Chloriti 7.14%, Alumen 1.43%, Scorpio 5.72%, Ramulus Uncariae Cum Uncis 4.76%, Rhizoma Acori Graminei 2.38%, Pumex 4.76%, Borneolum Syntheticum 7.14%, Succinum powder 4.76%, Sucus Zingberis 2.86%, Semen Pharbitidis 3.33%, the Radix Paeoniae Alba 4.76%, Radix Bupleuri 4.76%

The pharmacology of institute of the present invention foundation is blood circulation promoting and blood stasis dispelling, sensiblely decides epilepsy.

The present invention compares background technology and has the following advantages:

1. confirm that through animal experiment this medicine safety range is big, has no side effect; 2. administrated method is simple; 3. perpetual good effect does not recur after the drug withdrawal; 4. the curative effect height according to random sampling, is taken in patient's 189 examples of Xifengdingjian pill capable of calming endopathic wind and alleviating epilepsy, and except that 5 routine seizure frequency no changes, 184 routine onset times the shortest were 10 days, and are the longest 120 days.Remarkable efficient 651% among the 189 routine patients, effective percentage 32.3%, inefficiency 2.6%, total effective rate is 97.4%, does the electroencephalogram contrast before and after the treatment of this group, electroencephalogram change rate reaches 73.7%, by statistics Analysis of X ²=26.03, P＜0.001 reaches significant difference.

Be described in further detail below in conjunction with embodiment:

Embodiment 1:

Pharmaceutical formulation:

Arisaema Cum Bile 4.76 grams, Rhizoma Gastrodiae 1.93 grams, method half is 4.76 grams again, Pheretima 4.76 grams, Radix Aristolochiae 4.76 grams, Herba Pogostemonis 4.76 grams, Pericarpium Citri Reticulatae 4.76 grams, Concretio Silicea Bambusae 3.81 grams, Lignum Aquilariae Resinatum 4.76 grams, Bulbus Fritillariae Cirrhosae 4.76 grams, Radix Et Rhizoma Rhei 2.38 grams are forged Lapis Chloriti 7.14 grams, Alumen 1.43 grams, Scorpio 5.72 grams, Ramulus Uncariae Cum Uncis 4.76 grams, Rhizoma Acori Graminei 2.38 grams, Pumex 4.76 grams, Borneolum Syntheticum 7.14 grams, Succinum powder 4.76 grams, Sucus Zingberis 2.86 grams, Semen Pharbitidis 3.33 grams, the Radix Paeoniae Alba 4.76 grams, Radix Bupleuri 4.76 grams.

Above-mentioned respectively distinguish the flavor of medicine through clean remove the impurity big gun and process after, be broken into fine powder by as above weight mixed powder, cross 100 mesh sieve mixings, in medicated powder, add in the refining of 100-140 gram closely then, be mixed into sticking together of soft or hard appropriateness, stick together through branch, operations such as rubbing, pelleting are promptly made.

The instructions of taking of this medicine and consumption: take with boiled water after meal, every day 2 times, each 2 balls, 18 grams, or follow the doctor's advice.

Embodiment 2:

Model case:

Li Shunqi, man, 35 years old, epileptics grand mal 1 year 03 months, the patient be on January 21st, 1984 head in construction pounded fracture, after the row operation of opening cranium of total institute of Tangshan Kailuan Mining Affairs Bureau, recovery from illness in 4 months is left hospital, and goes home to faint suddenly in back 20 days, syncope, two fixed staring upward, gnathospasma, slobbering, tic of the limbs, urinary incontinence, alleviate after about 1 hour, memoryless afterwards, being admitted to hospital once more is diagnosed as traumatic epilepsy, treats not feel any better in one month and leave hospital.Successively go Beijing, the treatment of Tianjin various big hospital, diphenylhydantoin oral suspension sodium, carbamazepine can not control of seizures.Be epilepsy grand mal during paresthesia epilepsy, show effect 2-3 every day, puckery with headache, weak, numb limbs and tense tendons, purplish tongue, white and thin fur, stringy and thready pulse.The electroencephalogram prompting: a light moderate is unusual, and the patient came to go to a doctor on October 3rd, 1985, was diagnosed as epilepsy, take this ball to it, every day 2 times, each 18, taking medicine after meal advises it to reduce the Western medicine consumption gradually, withdraws after 30 days, treat and show effect altogether 2 times during 60 days, clothes control of seizures after 120 days, spirit is good, the appetite sleep is normal, treat check electroencephalogram prompting after 180 days, roughly normal, drug withdrawal is observed.On June 12nd, 1992 followed up a case by regular visits at last and has stopped showing effect 6 years 04 months.

Claims

1. manufacture method for the treatment of the pill of epileptics, it is characterized in that connecing Arisaema Cum Bile 4.66-4.86%, Rhizoma Gastrodiae, 1.83-2.03%, Rhizoma Pinelliae Preparatum 4.76-4.81%, Pheretima 4.66-4.86%, Radix Aristolochiae 4.66-4.86%, Herba Pogostemonis 4.664.86%, Pericarpium Citri Reticulatae 4.66-4.86%, Concretio Silicea Bambusae 3.71-3.91%, Lignum Aquilariae Resinatum 4.66-4.86%, Bulbus Fritillariae Cirrhosae 4.66-4.86%, Radix Et Rhizoma Rhei 2.33-2.43%, forge Lapis Chloriti 7.047.24%, Alumen 1.33-1.53%, Scorpio 5.60-5.77%, Ramulus Uncariae Cum Uncis 4.66-4.86%, Rhizoma Acori Graminei 2.28-2.48%, Pumex 4.66-4.86%, Borneolum Syntheticum 7.04-7.24%, Succinum powder 4.66-4.86%, Sucus Zingberis 2.76-2.96%, Semen Pharbitidis 3.283.38%, Radix Paeoniae Alba 4.66-4.86%, the weight ratio of Radix Bupleuri 4.66-4.86% takes by weighing mixed powder and is broken into fine powder, cross 100 mesh sieve mixings, add in the 1-1.4 refining doubly of medicated powder weight closely then in medicated powder, be mixed into and stick together, branch sticks together, rubbing, pelleting.