CN1054526C

CN1054526C - "Dianxianningxiwan" pills-Chinese patent medicine for epilepsy

Info

Publication number: CN1054526C
Application number: CN96100072A
Authority: CN
Inventors: 谢志庆
Original assignee: Individual
Current assignee: Individual
Priority date: 1996-01-05
Filing date: 1996-01-05
Publication date: 2000-07-19
Anticipated expiration: 2016-01-05
Also published as: CN1134298A

Abstract

The present invention relates to a Chinese patent medicine for treating epilepsy, which is an oral Chinese patent medicine prepared from raw materials of traditional Chinese medicines, such as ginseng, human placenta, ophiopogon root, platycodon root, wolfberry bark, bupleurum root, baical skullcap root, calculus bovis, cinnabar, pearl, succinum, thinleaf milkwort root, tuckahoe, musk, gastrodia tuber, fineleaf schizonepeta herb, cicada slough, giant typhonium rhizome, hemlock parsley, etc., according to formula principles of invigorating the liver and the spleen, clearing heat for calming endogenous wind, treating convulsion, activating collaterals, tranquilizing the mind and quieting the spirit. The Chinese patent medicine has the advantages of small toxic or side effects and favorable clinical treating effects.

Description

The Chinese patent medicine of treatment epilepsy

The invention belongs to a kind of Chinese patent medicine for the treatment of epileptics.

Epilepsy is neural a kind of commonly encountered diseases, its cause of disease complexity, and outbreak repeatedly is difficult to radical cure, and doctor trained in Western medicine is many to take downern for a long time to the treatment of primary disease, and curative effect is not consolidated and is imprecise.The Chinese traditional treatment epilepsy is with a long history, to the formation of primary disease, cures house mostly and all thinks to be owing to incoordination of seven emotions, congenital factors, cerebral trauma, overwork or suffer from after its disease, form the imbalance of brain internal organs, the turbid retardance of expectorant, mechanism of qi is disorderly contrary, due to moving in the wind sun, and wherein haunt with the expectorant heresy is principal element, also has many doctors family to think, expectorant, wind, heat, shies in scar epilepsy disease and plays an important role, so heat clearing away is emphasized in medication in treatment, by expectorant, suppressing the hyperactive liver stops burning, and spasmolytic is only taken out.These medicines all have certain curative effect to the treatment epileptics, but await further to improve its clinical therapeutic efficacy.

The present invention aims to provide that a kind of toxic and side effects is little, the Chinese patent medicine of the treatment epileptics that can obtain better curative effect.

The technical scheme that realizes above-mentioned purpose is: raw material that Chinese patent medicine of the present invention adopts and weight proportion are (b is Unit Weight part)

Radix Ginseng 13-17b Placenta Hominis 10-14b 8-12b Radix Ophiopogonis Radix Platycodonis 5-7b

Cortex Lycii 6-8b Radix Bupleuri 7-9b Radix Scutellariae 10-14b Calculus Bovis 3-5b

Cinnabaris 8-12b Margarita 7-9b succinum 5-7b Radix Polygalae 7-9b

Poria 7-9b Moschus 0.5-1.5b Rhizoma Gastrodiae 7-9b Herba Schizonepetae 8-12b

Periostracum Cicadae 2-4b Radix Aconiti Coreani 2-4b Rhizoma Chuanxiong 10-14b

Above-mentioned materials of weight proportions is made oral Chinese patent medicine.

Also be added with following Chinese medicinal raw materials in the above-mentioned medicine:

Rhizoma Atractylodis Macrocephalae 8-12b Radix Glycyrrhizae 2-4b Fructus Aurantii 7-9b Massa Medicata Fermentata 6-8b

Concretio Silicea Bambusae 2-4b Chalcanthitum 5-7b Realgar 2-4b Arisaema Cum Bile 7-9b

Herba Ephedrae 2-4b Scorpio 10-14b Cornu Bubali 27-33b Radix Saposhnikoviae 2-4b

Fructus Gleditsiae Abnormalis 2-4b Herba Menthae 2-4b Borneolum Syntheticum 0.2-0.4b

It is considered herein that though the epilepsy clinical manifestation is complicated unusually, its pathogeny mainly is due to deficiency in origin and excess in superficiality, the mental disorder superinverse, so-called " deficiency in origin ", one be the natural endowment deficiency, one be the day after tomorrow taste lack of proper care.So-called " mark is real " promptly is the liver wind-phlegm-heat.Epilepsy causes from expectorant, and expectorant goes out from spleen, so insufficiency of the spleen expectorant volt is the major lesions basis of epilepsy syndrome.In addition, with the hot folder of fire rising folder is frightened mutually in the kidney much relations are arranged also, so the theory of Chinese medical science that basis " is controlled wind and controlled blood, blood sector-style earlier from going out ", the method for the endogenous wind stopping of invigorating blood circulation is used in attention.

Comprehensive above-mentioned reason, the present invention makes up a prescription according to the principles of formulating prescriptions of " invigorating liver and spleen, clearing heat for calming endogenous wind, active, the tranquillizing and allaying excitement of spasmolytic ".Aforementioned raw material of Chinese medicine can divide four classes:

1, tonification class-based on Radix Ginseng, Placenta Hominis, Radix Ophiopogonis, Radix Platycodonis etc.The rule of treatment of liver and kidney tonifying as treatment, reused Radix Ginseng, two kinds of tonics of Placenta Hominis especially, except that benefiting action, Radix Ginseng can also be regulated big mesencephalic centre, and Placenta Hominis contains polysaccharide body and hormone, can strengthen the human body resistance against diseases, nourishes blood, the smart effect of benefit.

2, clearing heat for calming endogenous wind class-comprise Cortex Lycii, Radix Bupleuri, Radix Scutellariae, Calculus Bovis, the pathogeny system of scar epilepsy is relevant with internal organs dysfunction, and in close relations with liver spleen heart kidney; as the hepatic and renal YIN deficiency, the kidney failing to nourish the liver, the prosperous fire-transformation of art; the extreme heat causing wind syndrome liver-wind stirring up internally occurs limbs then and twitches.So clearing heat for calming endogenous wind is the method for effecting a permanent cure really.Calculus Bovis in this type of medicine contains cholic acid, cholesterol etc., contains several amino acids and vitamin again, and pharmacological research has convulsion, refrigeration function, is the main medicine of controlling this disease; Cortex Lycii has heat clearing away, sedation, cooperates with Radix Bupleuri, Radix Scutellariae etc., and purging liver-fire is had obvious effect.

3, tranquillizing and allaying excitement class-based on Cinnabaris, Margarita, succinum, Radix Polygalae, Poria etc.Epilepsy is caused a disease by taking fright suddenly more than levying, and therefore, tranquillizing and allaying excitement system controls the essential product of epilepsy.

4, the active class of spasmolytic-based on Moschus, Rhizoma Gastrodiae, Herba Schizonepetae, Periostracum Cicadae, Scorpio, Radix Aconiti Coreani, Rhizoma Chuanxiong etc.Moschus contains muscone, and unconsciousness and delirium, convulsion with spasms are had inhibitory action, and Rhizoma Gastrodiae, Scorpio contain glycoside and biological alkali, experimental results show that epilepsy effectively, and Rhizoma Chuanxiong, Periostracum Cicadae are blood-activating and qi-promotings, the product of the wind spasmolytic of loosing.

More than four class medicines, interknit again, its pharmacological action complements each other, promote mutually.Prescription is reused tonics such as Radix Ginseng and Placenta Hominis especially, to improving the reparation of human body brain cell, improves autoimmune function, and very ideal effect is all arranged.Full side's compatibility is seen from the patient is whole, both takes stopgap measures, and effects a permanent cure again.Do not use Great Cold in the prescription, the product of big cold, do not use insect medicine yet, gentle, the safety of the property of medicine is not found any side effect in taking medicine, the patient is easy to acceptance.

This Chinese patent medicine once was used for the treatment of the thousands of examples of epileptic, had been 50 complete routine statistics of data logging since 92 years below:

1, in clinical data 50 examples, male 21 examples, women 29 examples; 12 examples below 20 years old, 21-30 year 18 examples, 31-40 year 9 examples, 11 examples more than 40 years old.

2, the whole patients of Therapeutic Method and curative effect are based on oral medicine, oral three times of every day, each ball.Inactive gradually other calm Western medicine in the medication process is with other decoction of the suitable adapted of other symptom.All add up curative effect two courses of treatment of patient's medication (after two months).

3, criterion of therapeutical effect is with reference to fixed standard judgement in November, 85 " first national epilepsy academic conference of Chinese Medical Association ".

4, curative effect statistics

	20 years old	21-30 year	31-40 year	More than 41 years old	Subtotal
	20 years old	21-30 year	31-40 year	More than 41 years old	Subtotal	The invalid total of recovery from illness improvement	5 7 0 12	6 11 1 18	4 4 1 9	4 5 2 11	19(38％) 27(54％) 4(4％) 50

By above statistics as can be known, this medicine is the highest to the effective percentage of patient below 30 years old, and is relatively poor to curative effect more than 41 years old.

In addition, this is organized among the 50 routine patients, has 32 examples to make EEG (electrocardiogram) examination, and electroencephalogram deviant 27 examples in 32 examples are transferred to normally or normal substantially by undesired with this medicine treatment back 21 routine electroencephalograms, and electroencephalogram improvement rate is 78%.

Model case

Lee, man, 26 years old, the workman lives the Xian City, Shanxi Province and builds worker office dormitory, first visit in October 12 in 93 year, readme is had a fever suddenly in June, 91, dementia occurs, obnubilation, be interrupted and occur the whole body twitch after several days, order is stayed obnubilation, continues about one minute, outbreak back general weakness is made EEG (electrocardiogram) examination to local hospital, examines to be slight electroencephalogram slow wave, show effect 5-6 every day, and the sample of nodding is twitched, and the outbreak in afternoon frequently.

Look into patient's pale tongue, white and thin fur, slippery and rapid pulse is examined and is the epilepsy partial seizure.Treat oral three times of every day, each ball with this medicine " Dianxianningxiwan " from October 14th, 93, check at the beginning of 11 months, mental symptom is greatly improved, and attack times has reduced to two days once, continues and takes this medicine 15 days, the patient does not reaccess, appetite is improved, and sleep is normal, and spirit is more preceding greatly to take a turn for the better, basic disease is more checked electroencephalogram and has been transferred to normally.So far not morbidity again, efficacy consolidation.

Therefore the present invention provides the oral Chinese patent medicine that a kind of toxic and side effects is little, curative effect is high for the treatment epileptics.

1 example of embodiment adopts following Chinese medicine raw materials by weight proportion (b is Unit Weight part)

Radix Ginseng 15b Placenta Hominis 12b 10b Radix Ophiopogonis Radix Platycodonis 6b

Cortex Lycii 7b Radix Bupleuri 8b Radix Scutellariae 12b Calculus Bovis 4b

Cinnabaris 10b Margarita 8b succinum 6b Radix Polygalae 8b

Poria 8b Moschus 1b Rhizoma Gastrodiae 8b Herba Schizonepetae 10b

Periostracum Cicadae 3b Radix Aconiti Coreani 3b Rhizoma Chuanxiong 12b

Rhizoma Atractylodis Macrocephalae 10b Radix Glycyrrhizae 3b Fructus Aurantii 8b Massa Medicata Fermentata 7b

Concretio Silicea Bambusae 3b Chalcanthitum 6b Realgar 3b Arisaema Cum Bile 8b

Herba Ephedrae 3b Scorpio 12b Cornu Bubali 30b Radix Saposhnikoviae 3b

Fructus Gleditsiae Abnormalis 3b Herba Menthae 3b Borneolum Syntheticum 0.3b

This example adds the Rhizoma Atractylodis Macrocephalae, Radix Glycyrrhizae, Fructus Aurantii, Massa Medicata Fermentata, Concretio Silicea Bambusae, Chalcanthitum, Realgar, Arisaema Cum Bile, Herba Ephedrae, Scorpio, Cornu Bubali, Radix Saposhnikoviae, Fructus Gleditsiae Abnormalis, Herba Menthae, Borneolum Syntheticum 15 flavor medicines in the medicines again at aforementioned 19 flavors, assists a ruler in governing a country further that aforementioned four class medicines performance invigorating liver and spleen, clearing heat for calming endogenous wind, spasmolytic are active, the drug effect of tranquillizing and allaying excitement.

Above-mentioned Chinese medicine raw materials by weight proportion is made the oral administration pills Chinese patent medicine.

Manufacture method is

1, takes by weighing raw material by aforementioned formula, screening, pulverize;

2, in medicated powder: the ratio of Mel=1: 1-1.2 adds Mel, makes the honeyed pill dosage form with conventional method, every ball 6g.

Instructions about how to take medicine:the adult obeys three times every day; each ball, and 30 days is a course of treatment.2 13b 14b 8b 7b 6b 9b 10b 5b 8b 9b 5b 9b 9b 1.5b 7b 12b 2b 4b 10b 8b 4b 7b 8b 2b 7b 2b 9b 2b 14b 27b 4b 2b 4b 0.2b3 17b 10b 12b 5b 8b 7b 14b 3b 12b 7b 7b 7b 7b 0.5b 9b 8b 4b 2b 14b 12b 2b 9b 6b 4b 5b 4b 7b 4b 10b 33b 2b 4b 2b 0.4b

Claims

1, the Chinese patent medicine of treatment epileptics is characterized in that this medicine adopts following Chinese medicine raw materials by weight proportion: