CN115645342A - Composition with anti-hair loss effect and application of composition in preparation of anti-hair loss shampoo - Google Patents
Composition with anti-hair loss effect and application of composition in preparation of anti-hair loss shampoo Download PDFInfo
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- CN115645342A CN115645342A CN202211321027.1A CN202211321027A CN115645342A CN 115645342 A CN115645342 A CN 115645342A CN 202211321027 A CN202211321027 A CN 202211321027A CN 115645342 A CN115645342 A CN 115645342A
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- 239000000203 mixture Substances 0.000 title claims abstract description 42
- 239000002453 shampoo Substances 0.000 title claims description 16
- 230000000694 effects Effects 0.000 title abstract description 16
- 230000003656 anti-hair-loss Effects 0.000 title abstract description 12
- 238000002360 preparation method Methods 0.000 title description 28
- 201000004384 Alopecia Diseases 0.000 claims abstract description 44
- 231100000360 alopecia Toxicity 0.000 claims abstract description 44
- 239000002994 raw material Substances 0.000 claims abstract description 18
- 241000830535 Ligustrum lucidum Species 0.000 claims abstract description 13
- 240000001341 Reynoutria japonica Species 0.000 claims abstract description 13
- 235000018167 Reynoutria japonica Nutrition 0.000 claims abstract description 13
- 241000304195 Salvia miltiorrhiza Species 0.000 claims abstract description 13
- 235000011135 Salvia miltiorrhiza Nutrition 0.000 claims abstract description 13
- 241000234314 Zingiber Species 0.000 claims abstract description 13
- 235000006886 Zingiber officinale Nutrition 0.000 claims abstract description 13
- 235000013399 edible fruits Nutrition 0.000 claims abstract description 13
- 235000008397 ginger Nutrition 0.000 claims abstract description 13
- 239000000654 additive Substances 0.000 claims abstract description 5
- 230000000996 additive effect Effects 0.000 claims abstract description 5
- 238000002156 mixing Methods 0.000 claims description 55
- 230000003405 preventing effect Effects 0.000 claims description 35
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 32
- 238000005360 mashing Methods 0.000 claims description 14
- 238000005406 washing Methods 0.000 claims description 14
- 238000009835 boiling Methods 0.000 claims description 7
- 239000000706 filtrate Substances 0.000 claims description 7
- 238000001914 filtration Methods 0.000 claims description 7
- 239000002671 adjuvant Substances 0.000 claims 1
- 239000004519 grease Substances 0.000 abstract description 5
- XYJRXVWERLGGKC-UHFFFAOYSA-D pentacalcium;hydroxide;triphosphate Chemical class [OH-].[Ca+2].[Ca+2].[Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O XYJRXVWERLGGKC-UHFFFAOYSA-D 0.000 description 56
- 238000003756 stirring Methods 0.000 description 42
- 229920001661 Chitosan Polymers 0.000 description 39
- 239000003795 chemical substances by application Substances 0.000 description 32
- 239000000047 product Substances 0.000 description 30
- 229910052588 hydroxylapatite Inorganic materials 0.000 description 19
- KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 description 18
- NBIIXXVUZAFLBC-UHFFFAOYSA-N Phosphoric acid Chemical compound OP(O)(O)=O NBIIXXVUZAFLBC-UHFFFAOYSA-N 0.000 description 16
- 230000000149 penetrating effect Effects 0.000 description 16
- 210000004209 hair Anatomy 0.000 description 13
- 239000000243 solution Substances 0.000 description 13
- IXPNQXFRVYWDDI-UHFFFAOYSA-N 1-methyl-2,4-dioxo-1,3-diazinane-5-carboximidamide Chemical compound CN1CC(C(N)=N)C(=O)NC1=O IXPNQXFRVYWDDI-UHFFFAOYSA-N 0.000 description 12
- 235000010413 sodium alginate Nutrition 0.000 description 12
- 239000000661 sodium alginate Substances 0.000 description 12
- 229940005550 sodium alginate Drugs 0.000 description 12
- 239000000080 wetting agent Substances 0.000 description 12
- 125000002349 hydroxyamino group Chemical group [H]ON([H])[*] 0.000 description 9
- 229910052708 sodium Inorganic materials 0.000 description 9
- 239000011734 sodium Substances 0.000 description 9
- -1 sodium alkyl sulfonate Chemical class 0.000 description 9
- 229910000147 aluminium phosphate Inorganic materials 0.000 description 8
- 239000007853 buffer solution Substances 0.000 description 8
- 230000000052 comparative effect Effects 0.000 description 8
- VFKZECOCJCGZQK-UHFFFAOYSA-M 3-hydroxypropyl(trimethyl)azanium;chloride Chemical compound [Cl-].C[N+](C)(C)CCCO VFKZECOCJCGZQK-UHFFFAOYSA-M 0.000 description 6
- 229920002907 Guar gum Polymers 0.000 description 6
- 241000209094 Oryza Species 0.000 description 6
- 235000007164 Oryza sativa Nutrition 0.000 description 6
- 239000006087 Silane Coupling Agent Substances 0.000 description 6
- GMMUMXYUVFRBFV-UHFFFAOYSA-N dodecane;2-methyloxirane;oxirane Chemical compound C1CO1.CC1CO1.CCCCCCCCCCCC GMMUMXYUVFRBFV-UHFFFAOYSA-N 0.000 description 6
- 235000010417 guar gum Nutrition 0.000 description 6
- 239000000665 guar gum Substances 0.000 description 6
- 229960002154 guar gum Drugs 0.000 description 6
- 230000006872 improvement Effects 0.000 description 6
- 229940088640 ppg-25-laureth-25 Drugs 0.000 description 6
- 235000009566 rice Nutrition 0.000 description 6
- 210000004761 scalp Anatomy 0.000 description 6
- 230000028327 secretion Effects 0.000 description 5
- 238000006243 chemical reaction Methods 0.000 description 4
- 239000003974 emollient agent Substances 0.000 description 4
- 239000008055 phosphate buffer solution Substances 0.000 description 4
- 230000008859 change Effects 0.000 description 3
- 238000004140 cleaning Methods 0.000 description 3
- 210000003780 hair follicle Anatomy 0.000 description 3
- 238000000034 method Methods 0.000 description 3
- 230000002265 prevention Effects 0.000 description 3
- 210000002374 sebum Anatomy 0.000 description 3
- 238000012360 testing method Methods 0.000 description 3
- 230000003778 catagen phase Effects 0.000 description 2
- 230000003203 everyday effect Effects 0.000 description 2
- 239000006260 foam Substances 0.000 description 2
- 230000036632 reaction speed Effects 0.000 description 2
- WRIDQFICGBMAFQ-UHFFFAOYSA-N (E)-8-Octadecenoic acid Natural products CCCCCCCCCC=CCCCCCCC(O)=O WRIDQFICGBMAFQ-UHFFFAOYSA-N 0.000 description 1
- LQJBNNIYVWPHFW-UHFFFAOYSA-N 20:1omega9c fatty acid Natural products CCCCCCCCCCC=CCCCCCCCC(O)=O LQJBNNIYVWPHFW-UHFFFAOYSA-N 0.000 description 1
- QSBYPNXLFMSGKH-UHFFFAOYSA-N 9-Heptadecensaeure Natural products CCCCCCCC=CCCCCCCCC(O)=O QSBYPNXLFMSGKH-UHFFFAOYSA-N 0.000 description 1
- 208000001840 Dandruff Diseases 0.000 description 1
- OYHQOLUKZRVURQ-HZJYTTRNSA-N Linoleic acid Chemical compound CCCCC\C=C/C\C=C/CCCCCCCC(O)=O OYHQOLUKZRVURQ-HZJYTTRNSA-N 0.000 description 1
- ZQPPMHVWECSIRJ-UHFFFAOYSA-N Oleic acid Natural products CCCCCCCCC=CCCCCCCCC(O)=O ZQPPMHVWECSIRJ-UHFFFAOYSA-N 0.000 description 1
- 239000005642 Oleic acid Substances 0.000 description 1
- 239000002253 acid Substances 0.000 description 1
- 230000009471 action Effects 0.000 description 1
- 230000003698 anagen phase Effects 0.000 description 1
- 239000012752 auxiliary agent Substances 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 230000007547 defect Effects 0.000 description 1
- 238000004043 dyeing Methods 0.000 description 1
- 238000005516 engineering process Methods 0.000 description 1
- 230000012010 growth Effects 0.000 description 1
- 230000002401 inhibitory effect Effects 0.000 description 1
- QXJSBBXBKPUZAA-UHFFFAOYSA-N isooleic acid Natural products CCCCCCCC=CCCCCCCCCC(O)=O QXJSBBXBKPUZAA-UHFFFAOYSA-N 0.000 description 1
- OYHQOLUKZRVURQ-IXWMQOLASA-N linoleic acid Natural products CCCCC\C=C/C\C=C\CCCCCCCC(O)=O OYHQOLUKZRVURQ-IXWMQOLASA-N 0.000 description 1
- 235000020778 linoleic acid Nutrition 0.000 description 1
- ZQPPMHVWECSIRJ-KTKRTIGZSA-N oleic acid Chemical compound CCCCCCCC\C=C/CCCCCCCC(O)=O ZQPPMHVWECSIRJ-KTKRTIGZSA-N 0.000 description 1
- 210000003491 skin Anatomy 0.000 description 1
- 239000004094 surface-active agent Substances 0.000 description 1
- 208000024891 symptom Diseases 0.000 description 1
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- 230000003797 telogen phase Effects 0.000 description 1
- 231100000331 toxic Toxicity 0.000 description 1
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Classifications
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Landscapes
- Cosmetics (AREA)
Abstract
The invention discloses a composition with an anti-hair loss effect, which comprises the following raw materials in parts by weight: 3-6 parts of glossy privet fruit, 2-5 parts of cacumen biotae, 2-5 parts of ginger, 1-3 parts of fleece-flower root, 1-3 parts of salvia miltiorrhiza and 4-5 parts of auxiliary additive. The invention takes glossy privet fruit, cacumen biotae, ginger, fleece-flower root and salvia miltiorrhiza as raw materials, the raw materials are matched with one another, and the composition prepared by combining the raw materials can inhibit the generation of grease, obviously improve the alopecia efficiency and improve the use efficiency of the product.
Description
Technical Field
The invention relates to the technical field of alopecia prevention, and particularly relates to a composition with an alopecia prevention effect and application of the composition in preparation of anti-hair loss shampoo.
Background
Alopecia refers to the phenomenon of hair falling off the scalp. The hair which is normally shed is the hair in the catagen and the telogen, and the hair which enters the catagen and the hair which newly enters the anagen are constantly in dynamic balance; the shampoo is a hair care product with the functions of removing dandruff, treating oil, dyeing hair and the like. Shampoo contains a plurality of components, and the combined action of the components can play a role in cleaning scalp and hair. The most effective component of a shampoo is a surfactant which is used for cleaning hair and scalp, and when the shampoo is mixed with water, foam is generated, but the foam is not much reflected by the cleaning capability.
The scalp of seborrheic alopecia has excessive grease secretion, excessive sebum secretion is accumulated around hair follicles, even hair follicle holes are pressed or blocked, so that normal growth of the hairs is hindered, and in addition, oleic acid, linoleic acid and the like in the sebum secretion have toxic effect on the hair follicles when the amount of the sebum secretion is excessive; however, the existing shampoo can not inhibit the secretion of scalp grease, influence and reduce the anti-hair loss effect, and further improvement treatment is needed on the basis of the effect.
Disclosure of Invention
In view of the defects of the prior art, the invention aims to provide a composition with an anti-hair loss effect and application thereof in preparing anti-hair loss shampoo, so as to solve the problems in the background technology.
The technical scheme adopted by the invention for solving the technical problem is as follows:
the invention provides a composition with an anti-hair loss effect, which comprises the following raw materials in parts by weight:
3-6 parts of glossy privet fruit, 2-5 parts of cacumen biotae, 2-5 parts of ginger, 1-3 parts of fleece-flower root, 1-3 parts of salvia miltiorrhiza and 4-5 parts of auxiliary additive.
Preferably, the composition with the alopecia preventing effect comprises the following raw materials in parts by weight:
3-6 parts of glossy privet fruit, 2-5 parts of cacumen biotae, 2-5 parts of ginger, 1-3 parts of fleece-flower root, 1-3 parts of salvia miltiorrhiza and 4.5 parts of auxiliary additive.
Preferably, the auxiliary agent comprises the following raw materials in parts by weight: 3-5 parts of modified hydroxyapatite and 10-20 parts of chitosan penetrating agent; the preparation method of the modified hydroxyapatite comprises the following steps:
s01: putting hydroxyapatite into water with the weight of 4-7 times of that of the hydroxyapatite, and uniformly mixing the hydroxyapatite and the water for later use;
s02: adding 2-4 parts of hydroxy amino acid into 10-20 parts of phosphoric acid buffer solution, then adding 2-5 parts of silane coupling agent KH560 and 1-3 parts of sodium alkyl sulfonate, and fully mixing to obtain a treating agent;
s03: and adding the treating agent into the product S01, mixing according to the weight ratio of 1.
The inventor of the invention finds that the product is not added with the modified hydroxyapatite and the chitosan penetrating agent, the oil change rate of the product has a remarkable variation trend, meanwhile, the treating agent in the preparation of the modified hydroxyapatite is not added with the sodium alkylsulfonate and is not added with the hydroxy amino acid, the modified hydroxyapatite is replaced by the hydroxyapatite, the performance of the product has a variation trend, the modified hydroxyapatite and the chitosan penetrating agent in the product cooperate to enhance the effect, and the performance of the product is improved and optimized together; meanwhile, the preparation method of the modified hydroxyapatite has the most obvious improvement effect only by adopting the method of the invention.
Preferably, the pH value of the phosphoric acid buffer solution is 6.0-6.5.
Preferably, the rotation speed of the stirring reaction is 500-1000r/min, the stirring time is 20-30min, and the stirring temperature is 55-65 ℃.
Preferably, the preparation method of the chitosan penetrating agent comprises the following steps:
s11: adding 5-10 parts of chitosan into 10-20 parts of sodium alginate solution, stirring uniformly, then adding citric acid, and adjusting the pH value to 5.5;
s12: mixing 2-5 parts of PPG-25-laureth-25 and 1-3 parts of guar gum hydroxypropyl trimethyl ammonium chloride, adding into 5-10 parts of rice washing water, blending and mixing;
s13: and adding the product of S12 into S11, and stirring and mixing fully to obtain the chitosan wetting agent.
Preferably, the mass fraction of the sodium alginate solution is 20-25%.
Preferably, the rotation speed of the S13 for stirring and mixing fully is 1000-1500r/min, and the stirring time is 20-30min.
Preferably, the preparation method of the composition for preventing alopecia comprises the following steps: washing fructus Ligustri Lucidi, folium Platycladi, rhizoma Zingiberis recens, polygoni Multiflori radix, and Saviae Miltiorrhizae radix with water, draining, mashing in a mashing machine, adding 5-10 times of water, boiling with slow fire for 1-2 hr, filtering to remove residue, and mixing the filtrate with modified hydroxyapatite and chitosan penetrating agent to obtain composition with alopecia preventing effect.
The invention also provides application of the composition with the anti-hair loss effect in preparing the anti-hair loss shampoo.
Compared with the prior art, the invention has the following beneficial effects:
the invention takes glossy privet fruit, cacumen biotae, ginger, fleece-flower root and salvia miltiorrhiza as raw materials, the raw materials are matched with each other, the synergistic effect is realized by adding modified hydroxyapatite and chitosan penetrating agent, and the composition prepared by combining the raw materials has the advantages of inhibiting the generation of grease, obviously improving the alopecia efficiency and improving the use efficiency of the product.
Detailed Description
The technical solutions in the embodiments of the present invention are clearly and completely described below with reference to specific embodiments, and it is obvious that the described embodiments are only a part of the embodiments of the present invention, and not all embodiments. All other embodiments, which can be derived by a person skilled in the art from the embodiments given herein without making any creative effort, shall fall within the protection scope of the present invention.
The composition with the alopecia preventing effect comprises the following raw materials in parts by weight:
3-6 parts of glossy privet fruit, 2-5 parts of cacumen biotae, 2-5 parts of ginger, 1-3 parts of fleece-flower root, 1-3 parts of salvia miltiorrhiza, 3-5 parts of modified hydroxyapatite and 10-20 parts of chitosan penetrating agent.
The composition with the alopecia preventing effect comprises the following raw materials in parts by weight:
3-6 parts of glossy privet fruit, 2-5 parts of cacumen biotae, 2-5 parts of ginger, 1-3 parts of fleece-flower root, 1-3 parts of salvia miltiorrhiza, 3-5 parts of modified hydroxyapatite and 10-20 parts of chitosan penetrating agent.
The preparation method of the modified hydroxyapatite of the embodiment comprises the following steps:
s01: putting the hydroxyapatite into water with the weight 4-7 times of that of the hydroxyapatite, and uniformly mixing the hydroxyapatite and the water for later use;
s02: adding 2-4 parts of hydroxy amino acid into 10-20 parts of phosphoric acid buffer solution, then adding 2-5 parts of silane coupling agent KH560 and 1-3 parts of sodium alkyl sulfonate, and fully mixing to obtain a treating agent;
s03: and (3) adding the treating agent into the S01 product, mixing according to the weight ratio of 1.
The pH of the phosphoric acid buffer solution of this example was 6.0 to 6.5.
The stirring reaction of the embodiment has the rotation speed of 500-1000r/min, the stirring time of 20-30min and the stirring temperature of 55-65 ℃.
The preparation method of the chitosan penetrating agent of the embodiment comprises the following steps:
s11: adding 5-10 parts of chitosan into 10-20 parts of sodium alginate solution, stirring uniformly, then adding citric acid, and adjusting the pH value to 5.5;
s12: mixing 2-5 parts of PPG-25-laureth-25 and 1-3 parts of guar gum hydroxypropyl trimethyl ammonium chloride, adding into 5-10 parts of rice washing water, blending and mixing;
s13: and adding the product of S12 into S11, and stirring and mixing fully to obtain the chitosan wetting agent.
The mass fraction of the sodium alginate solution in this example is 20-25%.
In the embodiment, the rotation speed of the S13 for stirring and mixing is 1000-1500r/min, and the stirring time is 20-30min.
The preparation method of the composition with the alopecia preventing effect comprises the following steps: washing fructus Ligustri Lucidi, folium Platycladi, rhizoma Zingiberis recens, polygoni Multiflori radix, and Saviae Miltiorrhizae radix with water, draining, mashing in a mashing machine, adding 5-10 times of water, boiling with slow fire for 1-2 hr, filtering to remove residue, and mixing the filtrate with modified hydroxyapatite and chitosan penetrating agent to obtain composition with alopecia preventing effect.
The composition with the alopecia preventing effect is applied to preparing the alopecia preventing shampoo.
Example 1.
The composition with the alopecia preventing effect comprises the following raw materials in parts by weight:
3 parts of glossy privet fruit, 2 parts of cacumen biotae, 2 parts of ginger, 1 part of fleece-flower root, 1 part of salvia miltiorrhiza, 3 parts of modified hydroxyapatite and 10 parts of chitosan wetting agent.
The preparation method of the modified hydroxyapatite of the embodiment comprises the following steps:
s01: putting hydroxyapatite into water with the weight of 4 times, and uniformly mixing for later use;
s02: adding 2 parts of hydroxy amino acid into 10 parts of phosphoric acid buffer solution, then adding 2 parts of silane coupling agent KH560 and 1 part of sodium alkyl sulfonate, and fully mixing to obtain a treating agent;
s03: and adding the treating agent into the product S01, mixing according to the weight ratio of 1.
The pH of the phosphate buffer solution of this example was 6.0.
The stirring reaction speed in this example was 500r/min, the stirring time was 20min, and the stirring temperature was 55 ℃.
The preparation method of the chitosan penetrating agent of the embodiment comprises the following steps:
s11: adding 5 parts of chitosan into 10 parts of sodium alginate solution, stirring uniformly, then adding citric acid, and adjusting the pH value to 5.5;
s12: mixing 2 parts of PPG-25-laureth-25 and 1 part of guar gum hydroxypropyl trimethyl ammonium chloride, adding into 5 parts of rice washing water, blending and mixing;
s13: and adding the product of S12 into S11, and stirring and mixing fully to obtain the chitosan wetting agent.
The mass fraction of the sodium alginate solution in this example was 20%.
In the embodiment, the rotation speed for fully stirring and mixing S13 is 1000r/min, and the stirring time is 20min.
The preparation method of the composition with the alopecia preventing effect comprises the following steps: washing fructus Ligustri Lucidi, folium Platycladi, rhizoma Zingiberis recens, polygoni Multiflori radix, and Saviae Miltiorrhizae radix with water, draining, mashing in a mashing machine, adding 5 times of water, boiling with slow fire for 1 hr, filtering to remove residue, and mixing the filtrate with modified hydroxyapatite and chitosan penetrating agent to obtain the composition with alopecia preventing effect.
The composition with the alopecia preventing effect is applied to preparing the alopecia preventing shampoo.
Example 2.
The composition with the alopecia preventing effect comprises the following raw materials in parts by weight:
6 parts of glossy privet fruit, 5 parts of cacumen biotae, 5 parts of ginger, 3 parts of fleece-flower root, 3 parts of salvia miltiorrhiza, 5 parts of modified hydroxyapatite and 20 parts of chitosan wetting agent.
The preparation method of the modified hydroxyapatite of the embodiment comprises the following steps:
s01: putting hydroxyapatite into water with the weight 7 times of that of the hydroxyapatite, and uniformly mixing the hydroxyapatite and the water for later use;
s02: adding 4 parts of hydroxy amino acid into 20 parts of phosphoric acid buffer solution, then adding 5 parts of silane coupling agent KH560 and 3 parts of sodium alkyl sulfonate, and fully mixing to obtain a treating agent;
s03: and adding the treating agent into the product S01, mixing according to the weight ratio of 1.
The pH of the phosphate buffer solution of this example was 6.5.
In the present example, the rotation speed of the stirring reaction was 1000r/min, the stirring time was 30min, and the stirring temperature was 65 ℃.
The preparation method of the chitosan emollient of this example is as follows:
s11: adding 10 parts of chitosan into 20 parts of sodium alginate solution, stirring uniformly, then adding citric acid, and adjusting the pH value to 5.5;
s12: mixing 5 parts of PPG-25-laureth-25 and 3 parts of guar gum hydroxypropyl trimethyl ammonium chloride, adding into 10 parts of rice washing water, and blending and mixing;
s13: and adding the product of S12 into S11, and stirring and mixing fully to obtain the chitosan wetting agent.
The mass fraction of the sodium alginate solution in this example was 25%.
In the present example, the rotation speed of the stirring and mixing in S13 is 1500r/min, and the stirring time is 30min.
The preparation method of the composition with the alopecia preventing effect comprises the following steps: washing fructus Ligustri Lucidi, folium Platycladi, rhizoma Zingiberis recens, polygoni Multiflori radix, and Saviae Miltiorrhizae radix with water, draining, mashing in a mashing machine, adding 10 times of water, boiling with slow fire for 2 hr, filtering to remove residue, and mixing the filtrate with modified hydroxyapatite and chitosan penetrating agent to obtain composition with alopecia preventing effect.
The composition with the alopecia preventing effect is applied to preparing the alopecia preventing shampoo.
Example 3.
The composition with the alopecia prevention effect comprises the following raw materials in parts by weight:
3-6 parts of glossy privet fruit, 2-5 parts of cacumen biotae, 2-5 parts of ginger, 1-3 parts of fleece-flower root, 1-3 parts of salvia miltiorrhiza, 3-5 parts of modified hydroxyapatite and 10-20 parts of chitosan penetrating agent.
The preparation method of the modified hydroxyapatite of the embodiment comprises the following steps:
s01: putting hydroxyapatite into water with the weight 5.5 times of that of the hydroxyapatite, and uniformly mixing the hydroxyapatite and the water for later use;
s02: adding 3 parts of hydroxy amino acid into 15 parts of phosphoric acid buffer solution, then adding 3.5 parts of silane coupling agent KH560 and 2 parts of sodium alkyl sulfonate, and fully mixing to obtain a treating agent;
s03: and adding the treating agent into the product S01, mixing according to the weight ratio of 1.
The pH of the phosphate buffer solution of this example was 6.35.
The stirring reaction speed in this example is 750r/min, the stirring time is 25min, and the stirring temperature is 60 ℃.
The preparation method of the chitosan emollient of this example is as follows:
s11: adding 7.5 parts of chitosan into 15 parts of sodium alginate solution, stirring uniformly, then adding citric acid, and adjusting the pH value to 5.5;
s12: mixing 3.5 parts of PPG-25-laureth-25 with 2 parts of guar gum hydroxypropyl trimethyl ammonium chloride, adding into 7.5 parts of rice washing water, blending and mixing;
s13: and adding the product of S12 into S11, and stirring and mixing fully to obtain the chitosan wetting agent.
The mass fraction of the sodium alginate solution in this example was 22.5%.
In the embodiment, the rotation speed of the S13 for stirring and mixing is 1250r/min, and the stirring time is 25min.
The preparation method of the composition with the alopecia preventing effect comprises the following steps: washing fructus Ligustri Lucidi, folium Platycladi, rhizoma Zingiberis recens, polygoni Multiflori radix, and Saviae Miltiorrhizae radix with water, draining, mashing in a mashing machine, adding 7.5 times of water, boiling with slow fire for 1.5 hr, filtering to remove residue, and mixing the filtrate with modified hydroxyapatite and chitosan penetrating agent to obtain composition with alopecia preventing effect.
The composition with the alopecia preventing effect is applied to preparing the alopecia preventing shampoo.
Example 4.
The composition with the alopecia preventing effect comprises the following raw materials in parts by weight:
4 parts of glossy privet fruit, 3 parts of cacumen biotae, 3 parts of ginger, 2 parts of fleece-flower root, 2 parts of salvia miltiorrhiza, 4 parts of modified hydroxyapatite and 12 parts of chitosan penetrating agent.
The preparation method of the modified hydroxyapatite of the embodiment comprises the following steps:
s01: putting hydroxyapatite into water with the weight 5 times that of the hydroxyapatite, and uniformly mixing the hydroxyapatite and the water for later use;
s02: adding 3 parts of hydroxy amino acid into 2 parts of phosphoric acid buffer solution, then adding 3 parts of silane coupling agent KH560 and 2 parts of sodium alkyl sulfonate, and fully mixing to obtain a treating agent;
s03: and adding the treating agent into the product S01, mixing according to the weight ratio of 1.
The pH of the phosphate buffer solution of this example was 6.25.
The rotation speed of the stirring reaction in this example was 600r/min, the stirring time was 22min, and the stirring temperature was 57 ℃.
The preparation method of the chitosan emollient of this example is as follows:
s11: adding 6 parts of chitosan into 12 parts of sodium alginate solution, stirring uniformly, then adding citric acid, and adjusting the pH value to 5.5;
s12: mixing 3 parts of PPG-25-laureth-25 and 1.2 parts of guar gum hydroxypropyl trimethyl ammonium chloride, adding into 6 parts of rice washing water, blending and mixing;
s13: and adding the product of S12 into S11, and stirring and mixing fully to obtain the chitosan wetting agent.
The mass fraction of the sodium alginate solution in this example was 22%.
In the embodiment, the rotation speed for fully stirring and mixing S13 is 1200r/min, and the stirring time is 22min.
The preparation method of the composition with the alopecia preventing effect comprises the following steps: washing fructus Ligustri Lucidi, folium Platycladi, rhizoma Zingiberis recens, polygoni Multiflori radix, and Saviae Miltiorrhizae radix with water, draining, mashing in a mashing machine, adding 6 times of water, boiling with slow fire for 1.2 hr, filtering to remove residue, and mixing the filtrate with modified hydroxyapatite and chitosan emollient to obtain the composition with alopecia preventing effect.
The composition with the alopecia preventing effect is applied to preparing the alopecia preventing shampoo.
Comparative example 1.
In contrast to example 3, no modified hydroxyapatite was added.
Comparative example 2.
The difference from example 3 is that the treating agent in the preparation of the modified hydroxyapatite is not added with sodium alkyl sulfonate.
Comparative example 3.
The difference from example 3 is that no hydroxyamino acid was added to the treating agent in the preparation of modified hydroxyapatite.
Comparative example 4.
The difference from example 3 is that the modified hydroxyapatite is replaced by hydroxyapatite.
Comparative example 5.
Unlike example 3, no chitosan rinse was added.
Respectively testing the oil content of scalp by a tester with a grease tester Sebumeter SM815, recording as data of D0, washing hair once a day by adopting the product, testing the oil content of skin for 60 days, and recording the data;
oil content change rate = { (oil content after use of product-oil content before use of product)/oil content before use of product } × 100%
The performance of the products of examples 1-4 and comparative examples 1-5 were tested as follows:
as can be seen from comparative examples 1-5, examples 1-4;
the product of the invention is not added with modified hydroxyapatite and chitosan wetting agent, the oil change rate of the product has obvious variation trend, meanwhile, the treating agent in the preparation of the modified hydroxyapatite is not added with sodium alkylsulfonate and is not added with hydroxy amino acid, the modified hydroxyapatite is replaced by hydroxyapatite, the performance of the product has variation trend, the modified hydroxyapatite and the chitosan wetting agent in the product cooperate to increase the efficiency, and the performance of the product is improved and optimized together; meanwhile, the preparation method of the modified hydroxyapatite has the most obvious improvement effect only by adopting the method of the invention.
Selecting volunteers with seborrheic alopecia symptoms of more than 100 alopecia everyday to participate in the test, using the corresponding product for 1 time at fixed time in a unified guidance mode every day according to the following table mode, collecting fallen hairs and recording the using time of the following table to obtain an average integer;
as can be seen from examples 1-4 and comparative examples 1-5, the modified hydroxyapatite and chitosan wetting agent are not added, the improvement effect of the number of fallen off is not obvious after the product is used for 0-60 days, only the modified hydroxyapatite and the chitosan wetting agent are cooperated, the improvement efficiency is most obvious, meanwhile, the preparation methods of the modified hydroxyapatite are different, the hair treatment effect is different, and the improvement effect is most obvious only by adopting the method provided by the invention.
It will be evident to those skilled in the art that the invention is not limited to the details of the foregoing illustrative embodiments, and that the present invention may be embodied in other specific forms without departing from the spirit or essential attributes thereof. The present embodiments are therefore to be considered in all respects as illustrative and not restrictive, the scope of the invention being indicated by the appended claims rather than by the foregoing description, and all changes which come within the meaning and range of equivalency of the claims are therefore intended to be embraced therein.
Furthermore, it should be understood that although the present specification describes embodiments, not every embodiment includes only a single embodiment, and such description is for clarity purposes only, and it is to be understood that all embodiments may be combined as appropriate by one of ordinary skill in the art to form other embodiments as will be apparent to those of skill in the art from the description herein.
Claims (4)
1. The composition with the alopecia preventing effect is characterized by comprising the following raw materials in parts by weight:
3-6 parts of glossy privet fruit, 2-5 parts of cacumen biotae, 2-5 parts of ginger, 1-3 parts of fleece-flower root, 1-3 parts of salvia miltiorrhiza and 4-5 parts of auxiliary additive.
2. The composition with the alopecia preventing effect as claimed in claim 1, is characterized by comprising the following raw materials in parts by weight:
3-6 parts of glossy privet fruit, 2-5 parts of cacumen biotae, 2-5 parts of ginger, 1-3 parts of fleece-flower root, 1-3 parts of salvia miltiorrhiza and 4.5 parts of auxiliary additive.
3. The composition with alopecia preventing effect according to claim 1, wherein the composition with alopecia preventing effect is prepared by the following steps: washing fructus Ligustri Lucidi, folium Platycladi, rhizoma Zingiberis recens, polygoni Multiflori radix, and Saviae Miltiorrhizae radix with water, draining, mashing in a mashing machine, adding 5-10 times of water, boiling with slow fire for 1-2 hr, filtering to remove residue, and mixing the filtrate with auxiliary adjuvants to obtain composition with alopecia preventing effect.
4. Use of the composition having alopecia preventing effect according to any one of claims 1 to 3 for preparing a shampoo for preventing alopecia.
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Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6495174B1 (en) * | 2001-02-21 | 2002-12-17 | Sarfaraz K. Niazi | Herbal composition for the treatment of alopecia |
| CN103933508A (en) * | 2014-04-01 | 2014-07-23 | 邓林生 | Hair regenerator of sharing chills and fever medicines and preparation method thereof |
| CN106421922A (en) * | 2016-10-09 | 2017-02-22 | 太原理工大学 | Modified hydroxyapatite/carbon nanotube/polyetheretherketon composite material and preparation method thereof |
| CN110302351A (en) * | 2019-08-15 | 2019-10-08 | 广州楚颜化妆品有限公司 | Anticreep oil-control educates hair and smears cream liquid and preparation method thereof |
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2022
- 2022-10-26 CN CN202211321027.1A patent/CN115645342B/en active Active
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|---|---|---|---|---|
| US6495174B1 (en) * | 2001-02-21 | 2002-12-17 | Sarfaraz K. Niazi | Herbal composition for the treatment of alopecia |
| CN103933508A (en) * | 2014-04-01 | 2014-07-23 | 邓林生 | Hair regenerator of sharing chills and fever medicines and preparation method thereof |
| CN106421922A (en) * | 2016-10-09 | 2017-02-22 | 太原理工大学 | Modified hydroxyapatite/carbon nanotube/polyetheretherketon composite material and preparation method thereof |
| CN110302351A (en) * | 2019-08-15 | 2019-10-08 | 广州楚颜化妆品有限公司 | Anticreep oil-control educates hair and smears cream liquid and preparation method thereof |
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| 万红新: "中药治疗脂溢性脱发１００例", 《中国中医药现代远程教育》, vol. 11, no. 5, pages 25 - 26 * |
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