CN115624508A - Skin care composition and preparation method and application thereof - Google Patents
Skin care composition and preparation method and application thereof Download PDFInfo
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- CN115624508A CN115624508A CN202211334243.XA CN202211334243A CN115624508A CN 115624508 A CN115624508 A CN 115624508A CN 202211334243 A CN202211334243 A CN 202211334243A CN 115624508 A CN115624508 A CN 115624508A
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- extract
- skin care
- care composition
- menthol
- weight
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- 239000000203 mixture Substances 0.000 title claims abstract description 94
- 238000002360 preparation method Methods 0.000 title abstract description 13
- 239000000284 extract Substances 0.000 claims abstract description 119
- NOOLISFMXDJSKH-UTLUCORTSA-N (+)-Neomenthol Chemical class CC(C)[C@@H]1CC[C@@H](C)C[C@@H]1O NOOLISFMXDJSKH-UTLUCORTSA-N 0.000 claims abstract description 56
- 241000512259 Ascophyllum nodosum Species 0.000 claims abstract description 32
- WRIDQFICGBMAFQ-UHFFFAOYSA-N (E)-8-Octadecenoic acid Natural products CCCCCCCCCC=CCCCCCCC(O)=O WRIDQFICGBMAFQ-UHFFFAOYSA-N 0.000 claims abstract description 23
- LQJBNNIYVWPHFW-UHFFFAOYSA-N 20:1omega9c fatty acid Natural products CCCCCCCCCCC=CCCCCCCCC(O)=O LQJBNNIYVWPHFW-UHFFFAOYSA-N 0.000 claims abstract description 23
- QSBYPNXLFMSGKH-UHFFFAOYSA-N 9-Heptadecensaeure Natural products CCCCCCCC=CCCCCCCCC(O)=O QSBYPNXLFMSGKH-UHFFFAOYSA-N 0.000 claims abstract description 23
- 239000005642 Oleic acid Substances 0.000 claims abstract description 23
- ZQPPMHVWECSIRJ-UHFFFAOYSA-N Oleic acid Natural products CCCCCCCCC=CCCCCCCCC(O)=O ZQPPMHVWECSIRJ-UHFFFAOYSA-N 0.000 claims abstract description 23
- QXJSBBXBKPUZAA-UHFFFAOYSA-N isooleic acid Natural products CCCCCCCC=CCCCCCCCCC(O)=O QXJSBBXBKPUZAA-UHFFFAOYSA-N 0.000 claims abstract description 23
- ZQPPMHVWECSIRJ-KTKRTIGZSA-N oleic acid Chemical compound CCCCCCCC\C=C/CCCCCCCC(O)=O ZQPPMHVWECSIRJ-KTKRTIGZSA-N 0.000 claims abstract description 23
- 240000007474 Aloe arborescens Species 0.000 claims abstract description 16
- 235000004509 Aloe arborescens Nutrition 0.000 claims abstract description 16
- 241000167854 Bourreria succulenta Species 0.000 claims abstract description 16
- 235000019693 cherries Nutrition 0.000 claims abstract description 16
- 241000167550 Centella Species 0.000 claims abstract description 11
- 229940059958 centella asiatica extract Drugs 0.000 claims abstract description 5
- DNIAPMSPPWPWGF-UHFFFAOYSA-N Propylene glycol Chemical compound CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 claims description 30
- HEDRZPFGACZZDS-UHFFFAOYSA-N Chloroform Chemical compound ClC(Cl)Cl HEDRZPFGACZZDS-UHFFFAOYSA-N 0.000 claims description 26
- 229960001701 chloroform Drugs 0.000 claims description 25
- 239000000243 solution Substances 0.000 claims description 23
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 claims description 22
- BWZVCCNYKMEVEX-UHFFFAOYSA-N 2,4,6-Trimethylpyridine Chemical compound CC1=CC(C)=NC(C)=C1 BWZVCCNYKMEVEX-UHFFFAOYSA-N 0.000 claims description 20
- POJWUDADGALRAB-UHFFFAOYSA-N allantoin Chemical compound NC(=O)NC1NC(=O)NC1=O POJWUDADGALRAB-UHFFFAOYSA-N 0.000 claims description 20
- MGNCLNQXLYJVJD-UHFFFAOYSA-N cyanuric chloride Chemical compound ClC1=NC(Cl)=NC(Cl)=N1 MGNCLNQXLYJVJD-UHFFFAOYSA-N 0.000 claims description 20
- NOOLISFMXDJSKH-UHFFFAOYSA-N DL-menthol Natural products CC(C)C1CCC(C)CC1O NOOLISFMXDJSKH-UHFFFAOYSA-N 0.000 claims description 19
- 229940041616 menthol Drugs 0.000 claims description 19
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 19
- 239000002738 chelating agent Substances 0.000 claims description 14
- 239000003755 preservative agent Substances 0.000 claims description 14
- 230000002335 preservative effect Effects 0.000 claims description 14
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- 238000000034 method Methods 0.000 claims description 11
- POJWUDADGALRAB-PVQJCKRUSA-N Allantoin Natural products NC(=O)N[C@@H]1NC(=O)NC1=O POJWUDADGALRAB-PVQJCKRUSA-N 0.000 claims description 10
- SNPLKNRPJHDVJA-ZETCQYMHSA-N D-panthenol Chemical compound OCC(C)(C)[C@@H](O)C(=O)NCCCO SNPLKNRPJHDVJA-ZETCQYMHSA-N 0.000 claims description 10
- 229920002385 Sodium hyaluronate Polymers 0.000 claims description 10
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- 239000011259 mixed solution Substances 0.000 claims description 10
- 229940101267 panthenol Drugs 0.000 claims description 10
- 235000020957 pantothenol Nutrition 0.000 claims description 10
- 239000011619 pantothenol Substances 0.000 claims description 10
- 229940010747 sodium hyaluronate Drugs 0.000 claims description 10
- YWIVKILSMZOHHF-QJZPQSOGSA-N sodium;(2s,3s,4s,5r,6r)-6-[(2s,3r,4r,5s,6r)-3-acetamido-2-[(2s,3s,4r,5r,6r)-6-[(2r,3r,4r,5s,6r)-3-acetamido-2,5-dihydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-2-carboxy-4,5-dihydroxyoxan-3-yl]oxy-5-hydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-3,4,5-trihydroxyoxane-2- Chemical compound [Na+].CC(=O)N[C@H]1[C@H](O)O[C@H](CO)[C@@H](O)[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@H](O[C@H]2[C@@H]([C@@H](O[C@H]3[C@@H]([C@@H](O)[C@H](O)[C@H](O3)C(O)=O)O)[C@H](O)[C@@H](CO)O2)NC(C)=O)[C@@H](C(O)=O)O1 YWIVKILSMZOHHF-QJZPQSOGSA-N 0.000 claims description 10
- 238000003756 stirring Methods 0.000 claims description 10
- 229960005150 glycerol Drugs 0.000 claims description 8
- 229960004063 propylene glycol Drugs 0.000 claims description 8
- DFPAKSUCGFBDDF-UHFFFAOYSA-N Nicotinamide Chemical compound NC(=O)C1=CC=CN=C1 DFPAKSUCGFBDDF-UHFFFAOYSA-N 0.000 claims description 7
- 238000002156 mixing Methods 0.000 claims description 6
- 239000011570 nicotinamide Substances 0.000 claims description 6
- 229960003966 nicotinamide Drugs 0.000 claims description 6
- 235000005152 nicotinamide Nutrition 0.000 claims description 6
- 239000000230 xanthan gum Substances 0.000 claims description 5
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- 235000010493 xanthan gum Nutrition 0.000 claims description 5
- ZGTMUACCHSMWAC-UHFFFAOYSA-L EDTA disodium salt (anhydrous) Chemical compound [Na+].[Na+].OC(=O)CN(CC([O-])=O)CCN(CC(O)=O)CC([O-])=O ZGTMUACCHSMWAC-UHFFFAOYSA-L 0.000 claims description 4
- 239000004909 Moisturizer Substances 0.000 claims description 4
- DFPAKSUCGFBDDF-ZQBYOMGUSA-N [14c]-nicotinamide Chemical compound N[14C](=O)C1=CC=CN=C1 DFPAKSUCGFBDDF-ZQBYOMGUSA-N 0.000 claims description 4
- WPYMKLBDIGXBTP-UHFFFAOYSA-N benzoic acid Chemical compound OC(=O)C1=CC=CC=C1 WPYMKLBDIGXBTP-UHFFFAOYSA-N 0.000 claims description 4
- 230000001333 moisturizer Effects 0.000 claims description 4
- 230000008439 repair process Effects 0.000 claims description 4
- QCDWFXQBSFUVSP-UHFFFAOYSA-N 2-phenoxyethanol Chemical compound OCCOC1=CC=CC=C1 QCDWFXQBSFUVSP-UHFFFAOYSA-N 0.000 claims description 3
- 239000003109 Disodium ethylene diamine tetraacetate Substances 0.000 claims description 3
- 235000019301 disodium ethylene diamine tetraacetate Nutrition 0.000 claims description 3
- BEFDCLMNVWHSGT-UHFFFAOYSA-N ethenylcyclopentane Chemical compound C=CC1CCCC1 BEFDCLMNVWHSGT-UHFFFAOYSA-N 0.000 claims description 3
- 238000003760 magnetic stirring Methods 0.000 claims description 3
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- 238000007254 oxidation reaction Methods 0.000 claims description 3
- 229960005323 phenoxyethanol Drugs 0.000 claims description 3
- WVDDGKGOMKODPV-ZQBYOMGUSA-N phenyl(114C)methanol Chemical compound O[14CH2]C1=CC=CC=C1 WVDDGKGOMKODPV-ZQBYOMGUSA-N 0.000 claims description 3
- 235000010199 sorbic acid Nutrition 0.000 claims description 3
- 239000004334 sorbic acid Substances 0.000 claims description 3
- 229940075582 sorbic acid Drugs 0.000 claims description 3
- 239000005711 Benzoic acid Substances 0.000 claims description 2
- 230000004888 barrier function Effects 0.000 claims description 2
- 235000010233 benzoic acid Nutrition 0.000 claims description 2
- 229960004365 benzoic acid Drugs 0.000 claims description 2
- 238000004090 dissolution Methods 0.000 claims description 2
- 238000004519 manufacturing process Methods 0.000 claims 1
- 230000000694 effects Effects 0.000 abstract description 21
- 230000003020 moisturizing effect Effects 0.000 abstract description 12
- 238000010521 absorption reaction Methods 0.000 abstract description 11
- 230000008591 skin barrier function Effects 0.000 abstract description 7
- 230000003078 antioxidant effect Effects 0.000 abstract description 6
- 230000002195 synergetic effect Effects 0.000 abstract description 6
- 235000016709 nutrition Nutrition 0.000 abstract description 4
- 230000035764 nutrition Effects 0.000 abstract description 4
- 210000003491 skin Anatomy 0.000 description 104
- 230000000052 comparative effect Effects 0.000 description 48
- HHEAADYXPMHMCT-UHFFFAOYSA-N dpph Chemical compound [O-][N+](=O)C1=CC([N+](=O)[O-])=CC([N+]([O-])=O)=C1[N]N(C=1C=CC=CC=1)C1=CC=CC=C1 HHEAADYXPMHMCT-UHFFFAOYSA-N 0.000 description 10
- 210000004027 cell Anatomy 0.000 description 9
- 238000005303 weighing Methods 0.000 description 9
- 230000014759 maintenance of location Effects 0.000 description 8
- AUHZEENZYGFFBQ-UHFFFAOYSA-N 1,3,5-Me3C6H3 Natural products CC1=CC(C)=CC(C)=C1 AUHZEENZYGFFBQ-UHFFFAOYSA-N 0.000 description 6
- 239000011521 glass Substances 0.000 description 6
- GFYHSKONPJXCDE-UHFFFAOYSA-N sym-collidine Natural products CC1=CN=C(C)C(C)=C1 GFYHSKONPJXCDE-UHFFFAOYSA-N 0.000 description 6
- 241000699670 Mus sp. Species 0.000 description 5
- 230000001965 increasing effect Effects 0.000 description 5
- 150000002632 lipids Chemical class 0.000 description 5
- 230000002829 reductive effect Effects 0.000 description 5
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 4
- 238000004458 analytical method Methods 0.000 description 4
- 230000001737 promoting effect Effects 0.000 description 4
- 206010061218 Inflammation Diseases 0.000 description 3
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- 150000003254 radicals Chemical class 0.000 description 3
- 238000012360 testing method Methods 0.000 description 3
- 241000894006 Bacteria Species 0.000 description 2
- 241001474374 Blennius Species 0.000 description 2
- 102000008186 Collagen Human genes 0.000 description 2
- 108010035532 Collagen Proteins 0.000 description 2
- 230000000844 anti-bacterial effect Effects 0.000 description 2
- 230000008901 benefit Effects 0.000 description 2
- 239000003153 chemical reaction reagent Substances 0.000 description 2
- HVYWMOMLDIMFJA-DPAQBDIFSA-N cholesterol Chemical compound C1C=C2C[C@@H](O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H]([C@H](C)CCCC(C)C)[C@@]1(C)CC2 HVYWMOMLDIMFJA-DPAQBDIFSA-N 0.000 description 2
- 229920001436 collagen Polymers 0.000 description 2
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- 238000009792 diffusion process Methods 0.000 description 2
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- 150000004676 glycans Chemical class 0.000 description 2
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- 238000006467 substitution reaction Methods 0.000 description 2
- BDOYKFSQFYNPKF-UHFFFAOYSA-N 2-[2-[bis(carboxymethyl)amino]ethyl-(carboxymethyl)amino]acetic acid;sodium Chemical compound [Na].[Na].OC(=O)CN(CC(O)=O)CCN(CC(O)=O)CC(O)=O BDOYKFSQFYNPKF-UHFFFAOYSA-N 0.000 description 1
- KWIUHFFTVRNATP-UHFFFAOYSA-N Betaine Natural products C[N+](C)(C)CC([O-])=O KWIUHFFTVRNATP-UHFFFAOYSA-N 0.000 description 1
- VEXZGXHMUGYJMC-UHFFFAOYSA-M Chloride anion Chemical compound [Cl-] VEXZGXHMUGYJMC-UHFFFAOYSA-M 0.000 description 1
- 229920000832 Cutin Polymers 0.000 description 1
- FBPFZTCFMRRESA-KVTDHHQDSA-N D-Mannitol Chemical compound OC[C@@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-KVTDHHQDSA-N 0.000 description 1
- 102000016942 Elastin Human genes 0.000 description 1
- 108010014258 Elastin Proteins 0.000 description 1
- 102000004190 Enzymes Human genes 0.000 description 1
- 108090000790 Enzymes Proteins 0.000 description 1
- 102000009123 Fibrin Human genes 0.000 description 1
- 108010073385 Fibrin Proteins 0.000 description 1
- BWGVNKXGVNDBDI-UHFFFAOYSA-N Fibrin monomer Chemical compound CNC(=O)CNC(=O)CN BWGVNKXGVNDBDI-UHFFFAOYSA-N 0.000 description 1
- 206010020751 Hypersensitivity Diseases 0.000 description 1
- 238000012449 Kunming mouse Methods 0.000 description 1
- 229930195725 Mannitol Natural products 0.000 description 1
- KWIUHFFTVRNATP-UHFFFAOYSA-O N,N,N-trimethylglycinium Chemical compound C[N+](C)(C)CC(O)=O KWIUHFFTVRNATP-UHFFFAOYSA-O 0.000 description 1
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 1
- 239000004480 active ingredient Substances 0.000 description 1
- 208000026935 allergic disease Diseases 0.000 description 1
- 230000007815 allergy Effects 0.000 description 1
- 235000001014 amino acid Nutrition 0.000 description 1
- 150000001413 amino acids Chemical class 0.000 description 1
- 230000003064 anti-oxidating effect Effects 0.000 description 1
- 230000000259 anti-tumor effect Effects 0.000 description 1
- 239000003146 anticoagulant agent Substances 0.000 description 1
- 229940127219 anticoagulant drug Drugs 0.000 description 1
- 239000003963 antioxidant agent Substances 0.000 description 1
- 238000003556 assay Methods 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 229960003237 betaine Drugs 0.000 description 1
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- 238000004364 calculation method Methods 0.000 description 1
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- 235000012000 cholesterol Nutrition 0.000 description 1
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- 229920002549 elastin Polymers 0.000 description 1
- 230000007613 environmental effect Effects 0.000 description 1
- 238000002474 experimental method Methods 0.000 description 1
- 229950003499 fibrin Drugs 0.000 description 1
- 229910052739 hydrogen Inorganic materials 0.000 description 1
- 239000001257 hydrogen Substances 0.000 description 1
- -1 hydrogen tripolyphosphate Chemical class 0.000 description 1
- 230000036737 immune function Effects 0.000 description 1
- 230000036039 immunity Effects 0.000 description 1
- 230000001771 impaired effect Effects 0.000 description 1
- 230000006872 improvement Effects 0.000 description 1
- 230000001939 inductive effect Effects 0.000 description 1
- 229910052500 inorganic mineral Inorganic materials 0.000 description 1
- 230000031700 light absorption Effects 0.000 description 1
- 239000000594 mannitol Substances 0.000 description 1
- 235000010355 mannitol Nutrition 0.000 description 1
- 239000011707 mineral Substances 0.000 description 1
- 235000010755 mineral Nutrition 0.000 description 1
- 239000013642 negative control Substances 0.000 description 1
- 229930195732 phytohormone Natural products 0.000 description 1
- 230000008569 process Effects 0.000 description 1
- 238000012545 processing Methods 0.000 description 1
- 230000001681 protective effect Effects 0.000 description 1
- 102000004169 proteins and genes Human genes 0.000 description 1
- 108090000623 proteins and genes Proteins 0.000 description 1
- 230000004223 radioprotective effect Effects 0.000 description 1
- 230000009467 reduction Effects 0.000 description 1
- 230000008929 regeneration Effects 0.000 description 1
- 238000011069 regeneration method Methods 0.000 description 1
- 230000001105 regulatory effect Effects 0.000 description 1
- 210000002374 sebum Anatomy 0.000 description 1
- 230000028327 secretion Effects 0.000 description 1
- 238000000926 separation method Methods 0.000 description 1
- 210000004927 skin cell Anatomy 0.000 description 1
- 230000037394 skin elasticity Effects 0.000 description 1
- 235000019832 sodium triphosphate Nutrition 0.000 description 1
- 238000005507 spraying Methods 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 238000003786 synthesis reaction Methods 0.000 description 1
- 230000002194 synthesizing effect Effects 0.000 description 1
- 230000002936 tranquilizing effect Effects 0.000 description 1
- 235000013343 vitamin Nutrition 0.000 description 1
- 239000011782 vitamin Substances 0.000 description 1
- 229940088594 vitamin Drugs 0.000 description 1
- 229930003231 vitamin Natural products 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
- A61K8/9706—Algae
- A61K8/9711—Phaeophycota or Phaeophyta [brown algae], e.g. Fucus
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/34—Alcohols
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/36—Carboxylic acids; Salts or anhydrides thereof
- A61K8/361—Carboxylic acids having more than seven carbon atoms in an unbroken chain; Salts or anhydrides thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
- A61K8/9783—Angiosperms [Magnoliophyta]
- A61K8/9789—Magnoliopsida [dicotyledons]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
- A61K8/9783—Angiosperms [Magnoliophyta]
- A61K8/9794—Liliopsida [monocotyledons]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/08—Anti-ageing preparations
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
- A61K2800/59—Mixtures
- A61K2800/592—Mixtures of compounds complementing their respective functions
- A61K2800/5922—At least two compounds being classified in the same subclass of A61K8/18
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Birds (AREA)
- Biotechnology (AREA)
- Engineering & Computer Science (AREA)
- Mycology (AREA)
- Microbiology (AREA)
- Botany (AREA)
- Dermatology (AREA)
- Emergency Medicine (AREA)
- Gerontology & Geriatric Medicine (AREA)
- Cosmetics (AREA)
Abstract
The application discloses a skin care composition and a preparation method and application thereof, wherein the skin care composition comprises the following components of kelp extract, fig extract, aloe arborescens extract, cherry extract, centella asiatica extract, modified menthol and oleic acid; the weight ratio of the kelp extract to the fig extract to the aloe arborescens extract to the cherry extract to the centella extract is (18-22): (2-3): (0.3-0.8): (4-6): (0.4-0.7). According to the application, the kelp extract, the fig extract, the aloe arborescens extract, the cherry extract and the centella extract are compounded according to a specific proportion, so that the skin state can be effectively improved, the skin is endowed with strong moisturizing and antioxidant effects, and the nutrition repairing effect is achieved, so that the damaged skin barrier can be quickly and effectively repaired; meanwhile, the synergistic effect of the modified menthol and the oleic acid can effectively promote percutaneous absorption and improve the absorption effect of the effective components.
Description
Technical Field
The application relates to a skin care composition and a preparation method and application thereof, belonging to the technical field of skin care products.
Background
The herba Zosterae Marinae extract is rich in seaweed polysaccharide, mannitol, amino acids, vitamins, minerals, phytohormone, betaine, etc., and has antioxidant, anticoagulant, antitumor, antibacterial, blood sugar lowering, and radioprotective effects. The seaweed polysaccharide rich in the kelp extract can form a unique protective film on the cell surface, and protein molecules are effectively protected from being denatured and inactivated, so that the life process and biological characteristics of a living body are maintained. The unique functional characteristic is an important component of skin care products for keeping cell activity and moisturizing.
However, there are problems in using the kelp extract in skin care products. When the skin care product containing the kelp extract is used, the skin care product cannot be kept on the surface of the skin for a long time due to the influence of the temperature, humidity and the like of the surrounding environment, so that the absorption effect of the active ingredients in the kelp extract is poor, and the effect of the skin care product is reduced accordingly.
Disclosure of Invention
In order to solve the problems, the skin care composition and the preparation method and the application thereof are provided, the kelp extract, the fig extract, the aloe arborescens extract, the cherry extract and the centella extract are compounded according to a specific proportion, so that the skin state can be effectively improved, the skin is endowed with strong moisturizing and antioxidant effects, and the skin care composition has the function of nutrition restoration, so that the damaged skin barrier can be quickly and effectively restored; meanwhile, the synergistic effect of the modified menthol and the oleic acid can effectively promote percutaneous absorption and improve the absorption effect of the effective components.
According to one aspect of the present application, there is provided a skin care composition comprising the following components: kelp extract, fig extract, aloe arborescens extract, cherry extract, centella asiatica extract, modified menthol and oleic acid;
the weight ratio of the kelp extract to the fig extract to the aloe arborescens extract to the cherry extract to the centella extract is (18-22): (2-3): (0.3-0.8): (4-6): (0.4-0.7);
the modified menthol is prepared by the following method:
(1) Measuring cyanuric chloride and 2,4, 6-trimethyl pyridine to a round-bottom flask, adding chloroform, and dissolving cyanuric chloride to obtain a first solution;
(2) Measuring trichloromethane and menthol, completely dissolving the menthol by the trichloromethane, and standing for 15-20 min at 0 ℃ in an ice bath to obtain a second solution;
(3) And dropwise adding the first solution into the second solution at a constant speed, and reacting for 6-8 h under magnetic stirring at 15-25 ℃ to obtain the modified menthol.
Alternatively, in step (1), the molar ratio of cyanuric chloride to 2,4, 6-trimethylpyridine is 1: (4.5-5.5);
the weight ratio of the cyanuric chloride to the trichloromethane is (0.24-0.26): 1;
in the step (2), the weight ratio of the menthol to the trichloromethane is (0.12-0.14): 1.
optionally, the skin care composition further comprises a humectant, a preservative, a chelating agent, and a thickener.
Optionally, the humectant comprises one or more of glycerin, panthenol, sodium hyaluronate, niacinamide, propylene glycol, and allantoin;
the preservative comprises one or more of benzyl alcohol, benzoic acid, sorbic acid and phenoxyethanol;
the chelating agent comprises disodium ethylene diamine tetraacetate;
the thickener comprises xanthan gum.
Optionally, the moisturizer consists of glycerin, panthenol, sodium hyaluronate, niacinamide, propylene glycol, and allantoin; the weight ratio of the glycerol to the panthenol to the sodium hyaluronate to the nicotinamide to the propylene glycol to the allantoin is (4-6): (0.15 to 0.25): (0.03-0.08): (0.4-0.6): (1.5-2.5): (0.04-0.06).
Optionally, the weight of the preservative is 0.7-0.8% of the weight of the kelp extract;
the weight of the chelating agent is 0.13 to 0.18 percent of the mass of the kelp extract;
the weight of the thickening agent is 1.2-1.4% of the weight of the kelp extract.
According to another aspect of the present application, there is also provided a method of preparing the above skin care composition, comprising the steps of:
(1) Dissolving the kelp extract, the fig extract, the aloe arborescens extract, the cherry extract and the centella extract in water according to the weight ratio, and fully mixing to obtain a mixed solution;
(2) Adding modified menthol and oleic acid into the mixed solution obtained in the step (1), and uniformly stirring;
(3) And finally, sequentially adding the humectant, the preservative, the chelating agent and the thickening agent, and stirring for full dissolution to obtain the skin care composition.
Optionally, the weight of the water in the step (1) is 2-3 times of the sum of the weights of the extracts in the step (1).
Optionally, the weight of the modified menthol is 2-3% of the weight sum of the extracts, and the weight of the oleic acid is 1.3-1.8% of the weight sum of the extracts.
According to one aspect of the application, the application of the skin care composition or the skin care composition prepared by the preparation method in skin moisturizing, antioxidation and barrier repair is further provided.
Benefits of the present application include, but are not limited to:
1. according to the application, the kelp extract, the fig extract, the aloe arborescens extract, the cherry extract and the centella extract are compounded according to a specific proportion, so that the skin state can be effectively improved, the skin is endowed with strong moisturizing and antioxidant effects, and the nutrition repairing effect is achieved, so that the damaged skin barrier can be quickly and effectively repaired; meanwhile, the synergistic effect of the modified menthol and the oleic acid can effectively promote percutaneous absorption and improve the absorption effect of the effective components.
2. Modified menthol is adopted in the application, menthol and tripolyhydrogen chloride with multiple substitution positions are utilized to carry out nucleophilic substitution reaction, modified menthol is obtained, the modified menthol can promote diffusion of effective components on the horny layer on the one hand, fluidity of lipid among horny layer cells is increased, a polarity channel of the horny layer is opened, effective components are effectively promoted to be distributed to enter the horny layer, meanwhile, the modified menthol has certain antibacterial property, skin state can be effectively improved, and certain anti-inflammation and tranquilizing effects are achieved.
3. By adding the kelp extract, the immune function of cells can be effectively enhanced, and the effects of resisting inflammation, inducing cell activity, resisting free radicals, preserving moisture, inhibiting bacteria and the like are achieved; the fig extract can remove redundant cutin, so that the skin is smooth and lubricated; the aloe arborescens extract has various biological activities, has the effects of promoting the growth of fibrin, inhibiting elastin, synthesizing collagen and removing free radicals, has the effect of promoting the synthesis of cholesterol, is beneficial to changing the composition of sebum, reducing gloss and increasing the softness and moisture of skin, and also has the effects of resisting bacteria, diminishing inflammation and preserving moisture; the cherry extract can balance cortical secretion, help activate cells and beautify skin; the centella asiatica extract can promote skin collagen regeneration, enhance cell basal layer cell activity, keep skin elasticity and compactness, has the functions of resisting oxidation, inhibiting free radical activity and regulating skin immunity, can activate skin cells, resists allergy and protects skin from being damaged by the outside; the 5 extracts have synergistic effect, can effectively improve the skin state, endow the skin with strong moisturizing and antioxidant effects, have the function of nutrition restoration, and quickly and effectively restore the damaged skin barrier.
4. Modified menthol and oleic acid synergism are adopted in the application, so that the skin care composition has a good effect of promoting percutaneous absorption, menthol and hydrogen tripolyphosphate with multiple substitution positions are utilized to perform nucleophilic substitution reaction, modified menthol is obtained, the modified menthol can promote the diffusion of effective components in the horny layer on the one hand, the fluidity of lipid among horny layer cells is increased, a polar channel of the horny layer is opened, the effective components are effectively promoted to be distributed into the horny layer, oleic acid is used for decomposing a compact structure of the lipid of the horny layer, the fluidity of the lipid is increased, the resistance of the skin is reduced, and the lamellar regional layer separation of the lipid of the horny layer is increased, the two synergism are realized, so that the skin care composition has a good effect of promoting percutaneous absorption, and the absorption effect of the effective components is improved.
5. The preparation method of the skin care composition provided by the application has the advantages of simple steps, strong operability, environmental protection, no pollution, good completeness and repeatability and capability of realizing large-scale industrial continuous production.
Detailed Description
The present application will be described in detail with reference to examples, but the present application is not limited to these examples.
Unless defined otherwise, all technical and scientific terms used herein have the same meaning as commonly understood by one of ordinary skill in the art. The reagents or starting materials used in the present invention can be purchased from conventional sources, and unless otherwise specified, the reagents or starting materials used in the present invention can be used in a conventional manner in the art or in accordance with the product specification. In addition, any methods and materials similar or equivalent to those described herein can be used in the methods of the present invention. The preferred methods and materials described in this patent are for illustrative purposes only.
Example 1 skin Care composition 1#
Preparation of modified menthol No. 1
(1) Cyanuric chloride and 2,4, 6-collidine are weighed into a round-bottomed flask, and the molar ratio of the cyanuric chloride to the 2,4, 6-collidine is 1:4.5, adding trichloromethane, wherein the weight ratio of cyanuric chloride to trichloromethane is (0.24): 1, dissolving cyanuric chloride to obtain a first solution;
(2) Weighing trichloromethane and menthol, wherein the weight ratio of the menthol to the trichloromethane is 0.12:1, completely dissolving menthol by using trichloromethane, and standing for 15min at the temperature of 0 ℃ in an ice bath to obtain a second solution;
(3) Dropwise adding the first solution into the second solution at constant speed, and magnetically stirring at 15 deg.C for 6 hr to obtain modified menthol No. 1.
Preparation of skin care composition # 1
(1) According to the weight ratio of the kelp extract to the fig extract to the aloe arborescens extract to the cherry extract to the centella extract of 18:2:0.3:4:0.4 weighing each extract, dissolving in water, wherein the weight of the water is 2 times of the sum of the weight of each extract, and fully mixing to obtain a mixed solution;
(2) Adding modified menthol and oleic acid into the mixed solution obtained in the step (1), wherein the weight of the modified menthol is 2% of the sum of the weight of the extracts, and the weight of the oleic acid is 1.3% of the sum of the weight of the extracts, and uniformly stirring;
(3) Finally, sequentially adding a humectant into the mixture, wherein the weight ratio of glycerin, panthenol, sodium hyaluronate, nicotinamide, propylene glycol and allantoin in the humectant is 4:0.15:0.03:0.4:1.5:0.04 wt% of preservative benzyl alcohol, chelating agent disodium edetate and thickener xanthan gum, the weight of preservative is 0.7 wt% of herba Zosterae Marinae extract, the weight of chelating agent is 0.13 wt% of herba Zosterae Marinae extract, and the weight of thickener is 1.2 wt% of herba Zosterae Marinae extract, stirring and dissolving completely to obtain skin care composition # 1.
Example 2 skin care composition 2#
Preparation of modified menthol No. 2
(1) Cyanuric chloride and 2,4, 6-collidine are weighed into a round-bottomed flask, and the molar ratio of the cyanuric chloride to the 2,4, 6-collidine is 1:5.5, adding trichloromethane, wherein the weight ratio of cyanuric chloride to trichloromethane is 0.26:1, dissolving cyanuric chloride to obtain a first solution;
(2) Weighing trichloromethane and menthol, wherein the weight ratio of the menthol to the trichloromethane is 0.14:1, dissolving menthol completely by trichloromethane, and standing for 20min at 0 ℃ in an ice bath to obtain a second solution;
(3) Dropwise adding the first solution into the second solution at constant speed, and magnetically stirring at 25 deg.C for reaction for 8 hr to obtain modified menthol No. 2.
Preparation of skin care composition No. 2
(1) According to the weight ratio of the kelp extract to the fig extract to the aloe arborescens extract to the cherry extract to the centella extract of 22:3:0.8:6:0.7 weighing each extract, dissolving in water, wherein the weight of the water is 3 times of the sum of the weight of each extract, and fully mixing to obtain a mixed solution;
(2) Adding modified menthol and oleic acid into the mixed solution obtained in the step (1), wherein the weight of the modified menthol is 3 percent of the sum of the weight of the extracts, and the weight of the oleic acid is 1.8 percent of the sum of the weight of the extracts, and uniformly stirring;
(3) Finally, sequentially adding a humectant into the mixture, wherein the weight ratio of glycerin, panthenol, sodium hyaluronate, nicotinamide, propylene glycol and allantoin in the humectant is 6:0.25:0.08:0.6:2.5:0.06 percent of phenoxyethanol serving as a preservative, disodium ethylenediamine tetraacetate serving as a chelating agent and xanthan gum serving as a thickening agent, wherein the weight of the preservative is 0.8 percent of the weight of the kelp extract, the weight of the chelating agent is 0.18 percent of the weight of the kelp extract, and the weight of the thickening agent is 1.4 percent of the weight of the kelp extract, and the components are stirred and fully dissolved to obtain the skin care composition No. 2.
Example 3 skin Care composition 3#
Preparation of modified menthol No. 3
(1) Cyanuric chloride and 2,4, 6-collidine are weighed into a round-bottomed flask, and the molar ratio of the cyanuric chloride to the 2,4, 6-collidine is 1: and 5, adding trichloromethane, wherein the weight ratio of cyanuric chloride to trichloromethane is (0.25): 1, dissolving cyanuric chloride to obtain a first solution;
(2) Weighing trichloromethane and menthol, wherein the weight ratio of the menthol to the trichloromethane is 0.13:1, dissolving menthol completely by trichloromethane, and standing for 20min at 0 ℃ in an ice bath to obtain a second solution;
(3) And dropwise adding the first solution into the second solution at a constant speed, and reacting for 7 hours at 20 ℃ under magnetic stirring to obtain the modified menthol.
Preparation of skin care composition # 3
(1) According to the weight ratio of the kelp extract, the fig extract, the aloe arborescens extract, the cherry extract and the centella extract of 20:3:0.5:5:0.5 weighing each extract, dissolving in water, wherein the weight of the water is 3 times of the sum of the weight of each extract, and fully mixing to obtain a mixed solution;
(2) Adding modified menthol and oleic acid into the mixed solution obtained in the step (1), wherein the weight of the modified menthol is 2.5 percent of the weight sum of the extracts, and the weight of the oleic acid is 1.5 percent of the weight sum of the extracts, and uniformly stirring;
(3) And finally, sequentially adding a humectant, wherein the weight ratio of glycerin, panthenol, sodium hyaluronate, nicotinamide, propylene glycol and allantoin in the humectant is 5:0.2:0.05:0.5:2:0.05, preservative sorbic acid, chelating agent disodium ethylene diamine tetraacetic acid and thickening agent xanthan gum, wherein the weight of the preservative is 0.75 percent of that of the kelp extract, the weight of the chelating agent is 0.15 percent of that of the kelp extract, and the weight of the thickening agent is 1.3 percent of that of the kelp extract, and the components are stirred and fully dissolved to obtain the skin care composition No. 3.
Comparative example 1 comparative skin care composition 1#
Comparative example 1 differs from example 3 in that the menthol used was unmodified conventional menthol, the rest being the same.
Comparative example 2 comparative skin care composition 2#
Comparative example 2 differs from example 3 in that oleic acid is not included and the remainder are the same.
Comparative example 3 comparative skin care composition No. 3
Comparative example 3 differs from example 3 in that the weight ratio of kelp extract, fig extract, aloe arborescens extract, cherry extract, centella asiatica extract was 30:1:1:10:1, the rest are the same.
Comparative example 4 comparative skin care composition 4#
Comparative example 4 differs from example 3 in that the weight ratio of glycerin, panthenol, sodium hyaluronate, niacinamide, propylene glycol, allantoin is 8:0.5:0.1:0.2:3:0.1, the rest being the same.
Comparative example 5 comparative skin care composition 5#
Comparative example 5 differs from example 3 in that the weight ratio of modified menthol to oleic acid was 1:1, the rest are the same.
Experimental example 1 moisture retention test
8 glass plates with proper size are selected, a layer of medical breathable adhesive tape is pasted on the glass plates, and the glass plates are placed indoors overnight to enable the quality of the glass plates to be stable. Respectively weighing 0.5g of skin care composition No. 1-3 and comparative skin care composition No. 1-5, uniformly coating on an adhesive tape on a glass plate, recording the initial weight, respectively placing the glass plate in a drier for placing hygroscopic chemical substances, weighing and recording the mass of each sample after 48h, comparing the mass difference before and after placement, calculating the moisture retention rate W (%), and respectively carrying out 5 parts of parallel experiments on examples 1-3 and comparative examples 1-5.
W(％)＝M 2 /M 1 X 100% of formula (I) M 1 Is the sample mass before placement; m is a group of 2 The moisture retention rate was calculated for the mass of the sample after placement.
TABLE 1 moisturizing Properties of skin care compositions # 1-3 and comparative skin care compositions # 1-5
| Group of | Moisture retention rate 1 | Moisture retention rate 2 | Moisture retention rate 3 | Moisture retention rate 4 | Moisture retention rate 5 | Average |
| Skin care composition 1# | 87.6％ | 87.4％ | 87.6％ | 87.5％ | 87.5％ | 87.52％ |
| Skin care composition No. 2 | 87.7％ | 87.9％ | 87.5％ | 87.8％ | 87.8％ | 87.76％ |
| Skin care composition No. 3 | 87.4％ | 87.6％ | 86.9％ | 87.4％ | 87.5％ | 87.36％ |
| Comparative skin care composition # 1 | 86.6％ | 86.4％ | 86.2％ | 86.3％ | 86.3％ | 86.36％ |
| Comparative skin care composition No. 2# | 85.9％ | 85.7％ | 86.1％ | 86.2％ | 85.9％ | 85.96％ |
| Comparative skin Care composition No. 3 | 55.3％ | 55.2％ | 54.7％ | 55.1％ | 54.9％ | 55.04％ |
| Comparative skin care composition No. 4# | 61.3％ | 61.5％ | 61.2％ | 61.2％ | 61.4％ | 61.32％ |
| Comparative skin care composition No. 5# | 85.2％ | 85.2％ | 85.3％ | 85.4％ | 85.1％ | 85.24％ |
As can be seen from the data in table 1, the moisturizing rates of the comparative skin care composition # 3 and the comparative skin care composition # 4 are greatly reduced compared with those of the skin care compositions # 1 to # 3, and the analysis reason is that the ratio range of the extracts adopted by the comparative skin care composition # 3 is not within the range of the application, so that the synergistic effect among the components is weakened, the moisturizing performance is obviously reduced, and the specific ratio range of the extracts of the application has better moisturizing performance; the ratio of the humectant components used in comparative skin care composition # 4 was changed, resulting in a reduction in the moisturizing effect of comparative skin care composition # 4, indicating that the best moisturizing effect can be achieved at the particular ratio of the humectant components of the present application.
Experimental example 2 test for repairing skin Barrier
Taking 45 healthy female Kunming mice, weighing 25 +/-2 g, dividing the mice into 9 groups, 8 experimental groups and 1 blank group, unhairing the back of each group of 5 mice, cleaning the unhaired mice by normal saline, sticking the skin on the unhaired mice by a strong adhesive tape for 4 times, 2 times every day for 2 consecutive days, starting from the 3 rd day, not processing the blank group at the damaged parts of the mice, and respectively spraying the experimental groups with skin care compositions 1# to 3# and comparative skin care compositions 1# to 5# for 2 times every day. Percutaneous water loss (TEWL) was measured for 7 consecutive days, day 8.
| Group of | Transdermal water content (TEWL)/g.m -2 ·h -1 |
| Skin care composition 1# | 19.32±3.5 |
| Skin care composition No. 2 | 19.35±3.6 |
| Skin care composition No. 3 | 19.32±3.5 |
| Comparative skin Care composition No. 1 | 21.1±4.1 |
| Comparative skin Care composition No. 2 | 21.3±4.3 |
| Comparative skin care composition No. 3# | 29.6±7.9 |
| Comparative skin care composition No. 4# | 27.9±4.7 |
| Comparative skin care composition No. 5# | 22.3±3.7 |
| Blank group | 37.2±8.2 |
As can be seen from the data in the table above, the skin care composition No. 1-3 has lower percutaneous moisture loss, which indicates that the damaged skin sprayed with the skin care composition No. 1-3 has better skin barrier repair, while the percutaneous moisture loss is the highest compared with the skin care composition No. 3, and the analysis reason is that the proportion relation of the components of each extract is changed, so that the synergistic effect between the components is weakened, and the effect of repairing the skin barrier is reduced. The comparative skin care composition # 1, the comparative skin care composition # 2 and the comparative skin care composition # 5 also have higher percutaneous water loss, and the analysis reason is that the comparative skin care composition # 1 adopts unmodified menthol, and the comparative skin care composition # 2 does not contain oleic acid, and the comparative skin care composition # 5 changes the proportional relationship between the modified menthol and the oleic acid, so that the absorption effect of the skin care product is poor, and the repair effect on the damaged skin is further influenced.
Experimental example 3 Oxidation resistance test
Preparing 0.2mmol/L DPPH with 95% ethanol, mixing 100uL of skin care composition No. 1-3 and comparative skin care composition No. 1-5 with 100uL of DPPH solution in 96-well enzyme-labeled plate, reacting at room temperature in the dark for 30min, and measuring the light absorption value A1 at 517nm. 100uL of deionized water was reacted with 100uL of DPPH solution instead of 100uL of 95% ethanol to obtain a blank control group (A0), and 100uL of DPPH solution was reacted with 100uL of deionized water to obtain a negative control group (A2). The DPPH clearance calculation formula is as follows: DPPH clearance (%) = (A2-A1)/(A2-A0) × 100%, the results are shown in the table below.
| Group of | DPPH clearance (%) |
| Skin care composition 1# | 98.5±6.2 |
| Skin care composition No. 2 | 98.6±6.0 |
| Skin care composition No. 3 | 98.3±6.1 |
| Comparative skin care composition # 1 | 97.9±4.5 |
| Comparative skin Care composition No. 2 | 98.1±4.4 |
| Comparative skin care composition No. 3# | 78.6±6.6 |
| Comparative skin care composition No. 4# | 95.3±5.2 |
| Comparative skin care composition No. 5# | 94.9±6.1 |
As can be seen from the data in the above table, the skin care compositions 1# to 3# have the highest DPPH clearance, while the comparative skin care compositions 1# to 5# have different decreases in DPPH clearance than the skin care compositions 1# to 3# and the analysis reason is that the results are influenced to some extent by changing the proportional relationship of the extracts, the proportional relationship of the moisturizers and the proportional relationship of the modified menthol and the oleic acid. Wherein the comparative skin care composition No. 3 had the lowest DPPH clearance, and the assay reason is that it changed the ratio of the extracts, impaired the synergy between the components, resulting in the lowest antioxidant effect.
The above description is only an example of the present application, and the protection scope of the present application is not limited by these specific examples, but is defined by the claims of the present application. Various modifications and changes may occur to those skilled in the art to which the present application pertains. Any modification, equivalent replacement, improvement and the like made within the technical idea and principle of the present application should be included in the protection scope of the present application.
Claims (10)
1. A skin care composition comprising the following components: kelp extract, fig extract, aloe arborescens extract, cherry extract, centella asiatica extract, modified menthol and oleic acid;
the weight ratio of the kelp extract, the fig extract, the aloe arborescens extract, the cherry extract and the centella extract is (18-22): (2-3): (0.3-0.8): (4-6): (0.4 to 0.7);
the modified menthol is prepared by the following method:
(1) Measuring cyanuric chloride and 2,4, 6-trimethylpyridine into a round-bottom flask, adding trichloromethane, and dissolving the cyanuric chloride to obtain a first solution;
(2) Measuring trichloromethane and menthol, completely dissolving the menthol by the trichloromethane, and standing for 15-20 min at 0 ℃ in an ice bath to obtain a second solution;
(3) And dropwise adding the first solution into the second solution at a constant speed, and reacting for 6-8 h at 15-25 ℃ by magnetic stirring to obtain the modified menthol.
2. The skin care composition according to claim 1, wherein in step (1), the molar ratio of cyanuric chloride to 2,4, 6-trimethylpyridine is 1: (4.5-5.5);
the weight ratio of the cyanuric chloride to the trichloromethane is (0.24-0.26): 1;
in the step (2), the weight ratio of the menthol to the trichloromethane is (0.12-0.14): 1.
3. the skin care composition of claim 1, further comprising a humectant, a preservative, a chelating agent, and a thickener.
4. The skin care composition of claim 3 wherein the moisturizer comprises one or more of glycerin, panthenol, sodium hyaluronate, niacinamide, propylene glycol, allantoin;
the preservative comprises one or more of benzyl alcohol, benzoic acid, sorbic acid and phenoxyethanol;
the chelating agent comprises disodium ethylene diamine tetraacetate;
the thickener comprises xanthan gum.
5. The skin care composition of claim 4 wherein the moisturizer consists of glycerin, panthenol, sodium hyaluronate, niacinamide, propylene glycol, and allantoin; the weight ratio of the glycerol, the panthenol, the sodium hyaluronate, the nicotinamide, the propylene glycol and the allantoin is (4-6): (0.15-0.25): (0.03-0.08): (0.4-0.6): (1.5-2.5): (0.04-0.06).
6. The skin care composition according to claim 4, wherein the preservative is present in an amount of 0.7% to 0.8% by weight of the kelp extract;
the weight of the chelating agent is 0.13 to 0.18 percent of the mass of the kelp extract;
the weight of the thickening agent is 1.2-1.4% of the weight of the kelp extract.
7. A method of preparing a skin care composition according to any one of claims 1 to 6, comprising the steps of:
(1) Dissolving the kelp extract, the fig extract, the aloe arborescens extract, the cherry extract and the centella extract in water according to the weight ratio, and fully mixing to obtain a mixed solution;
(2) Adding modified menthol and oleic acid into the mixed solution obtained in the step (1), and uniformly stirring;
(3) And finally, sequentially adding the humectant, the preservative, the chelating agent and the thickening agent, and stirring for full dissolution to obtain the skin care composition.
8. The method according to claim 7, wherein the weight of the water in the step (1) is 2 to 3 times of the sum of the weights of the extracts in the step (1).
9. The method according to claim 7, wherein the weight of the modified menthol is 2 to 3% of the sum of the respective extracts, and the weight of the oleic acid is 1.3 to 1.8% of the sum of the respective extracts.
10. Use of a skin care composition according to any of claims 1 to 6 or a skin care composition prepared by the method of manufacture according to any of claims 7 to 9 for skin moisturization, oxidation resistance and barrier repair.
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| CN110522658A (en) * | 2019-09-23 | 2019-12-03 | 周璇 | A kind of antiallergic remediation composition and preparation method thereof |
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| CN109554150A (en) * | 2018-10-15 | 2019-04-02 | 哈尔滨工业大学无锡新材料研究院 | A kind of degradable super biological bonding agent of UV and preparation method thereof |
| CN110522658A (en) * | 2019-09-23 | 2019-12-03 | 周璇 | A kind of antiallergic remediation composition and preparation method thereof |
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