CN111773174A

CN111773174A - Yuling repairing cream and preparation method thereof

Info

Publication number: CN111773174A
Application number: CN202010768530.6A
Authority: CN
Inventors: 陈辉
Original assignee: Guangzhou Lize Cosmetics Co ltd
Current assignee: Guangzhou Lize Cosmetics Co ltd
Priority date: 2020-08-03
Filing date: 2020-08-03
Publication date: 2020-10-16
Anticipated expiration: 2040-08-03
Also published as: CN111773174B

Abstract

The invention relates to the field of skin care products, in particular to an age-defending repair cream and a preparation method thereof, and the age-defending repair cream mainly comprises the following components in percentage by mass: 0.5 to 1.5 percent of yeast fermentation product filtrate; 0.1 to 1 percent of buddleja officinalis extract; 1% -2% of phytosterol oleate; 0.8% -1.2% of hydrogenated lecithin; 1% -2% of glycerol stearate citrate; 2% -3% of polyglycerol-3-methylglucose distearate; 0.05 to 0.15 percent of sodium lauroyl lactylate; the balance of solvent; the total mass percentage is 100 percent. The invention has the effect of better anti-aging of the product.

Description

Yuling repairing cream and preparation method thereof

Technical Field

The invention relates to the technical field of skin care products, in particular to an age-defending repair cream and a preparation method thereof.

Background

At present, when people age gradually, the water loss of skin is accelerated, the elasticity of the skin is reduced, wrinkles gradually increase, and aging characteristics are more and more obvious, but along with the improvement of the attention of people to self maintenance, people mostly want to delay aging steps, and therefore people pay more and more attention to resisting aging.

The photoaging reaction, the saccharification reaction, the oxidation reaction, the metabolism slowing and the like are important reasons of skin aging, the skin aging is the result of comprehensive reflection in all aspects, and if the skin aging is only performed from one side, the anti-aging effect is difficult to reflect, the existing skin care product is usually adjusted from all aspects through matching and combining of components with different efficacies, so that the anti-aging effect is better, and the requirements of consumers are met.

The above prior art solutions have the following drawbacks:

however, in order to reduce the irritation of chemical synthetic raw materials to the skin, high-grade skin care products generally adopt various plant extracts as raw materials, and through the combination of plant extracts with different efficacies, the skin care products have different anti-aging effects, but when the components with different efficacies are mixed and matched, the generated effects are not always ideal, and the situations of mutual inhibition or mutual offset exist, so that the anti-aging effect of the product is not perfect, therefore, fewer products with better anti-aging effect are sold in the market, and an improvement space is provided.

Disclosure of Invention

Aiming at the defects in the prior art, the invention aims to provide an age-defending repair cream which has the effect of enabling the product to have better anti-aging effect.

In view of the defects of the prior art, the second purpose of the invention is to provide a preparation method of the imperial service cream, which has the effect that the effective components of each component are not easily damaged.

The above object of the present invention is achieved by the following technical solutions:

the anti-aging repair cream mainly comprises the following components in percentage by mass:

0.5 to 1.5 percent of yeast fermentation product filtrate;

0.1 to 1 percent of buddleja officinalis extract;

1% -2% of phytosterol oleate;

0.8% -1.2% of hydrogenated lecithin;

1% -2% of glycerol stearate citrate;

2% -3% of polyglycerol-3-methylglucose distearate;

0.05 to 0.15 percent of sodium lauroyl lactylate;

the balance of solvent;

the total mass percentage is 100 percent.

By adopting the technical scheme, the yeast fermentation product filtrate is added, contains main components of amino acid, nucleic acid, nucleotide, vitamin and mineral substance which are rich in natural moisturizing factors, is easy to be absorbed by the skin, helps the skin to retain moisture, enables the skin to recover elasticity, can promote metabolism, improves the synthesis speed of protein, can improve the oxidation resistance of the skin, and delays skin aging;

the flos Buddlejae extract can protect the integrity of skin barrier, resist ultraviolet and blue light to cause skin to generate free radicals, and contains abundant flavonoid compounds, so that the generation of free radicals can be reduced, and the oxidation resistance can be improved;

by adding the phytosterol oleate, the phytosterol oleate has certain oxidation resistance, can help skin retain moisture, promote skin metabolism, maintain skin elasticity and delay skin aging;

by adding the hydrogenated lecithin, the glycerol stearate citrate, the polyglycerol-3-methyl glucose distearate and the sodium lauroyl lactylate, the interfacial tension is reduced, so that the dissolving and dispersing effects of the components in a solvent are better, the components are mixed more uniformly, and the stable performance of the product efficacy is facilitated.

The product is enabled to resist aging in different aspects by adding the phytosterol oleate, the yeast fermentation product filtrate and the buddleja officinalis extract, the phytosterol oleate can also better relieve the inhibition effect between the yeast fermentation product and the buddleja officinalis extract, the yeast fermentation product filtrate and the buddleja officinalis extract are promoted to better exert respective effects, the effects are better after the phytosterol oleate, the yeast fermentation product filtrate and the buddleja officinalis extract are matched for use, and the anti-aging effect of the product is better.

The present invention in a preferred example may be further configured to: the Imperial age repairing cream also comprises the following components in percentage by mass:

0.2 to 0.8 percent of chinaroot greenbrier herb-lactone;

the hypecoum vulgare callus culture filtrate is 0.1-0.3%.

By adopting the technical scheme, the clitocybe lactone is added, so that the water loss can be prevented, irregular skin textures can be reduced, and the metabolism of the skin is accelerated, so that the skin is easy to keep a healthy state;

by adding the hypecoum vulgare callus culture filtrate, the hypecoum vulgare callus culture filtrate can effectively remove free radicals, has excellent oxidation resistance, accelerates the growth factor of vascular endothelium and the healing stage, activates the proliferation of fibroblast and the growth of collagen, effectively preserves moisture, effectively resists the damage of pollution in daily life to skin, can also inhibit the synthesis of melanin and control the migration of the melanin, and has better whitening effect.

3% -5% of squalane;

0.1 to 0.3 percent of bisabolol.

By adopting the technical scheme, squalane is added, is a component existing in the body, has particularly good skin-friendly property, can form a layer of breathable protective film on the surface layer of the skin, plays the effects of moisturizing and moistening the skin, can accelerate metabolism, increases the permeability of other components, and helps other effective components to be better absorbed;

by adding the bisabolol, the bisabolol has good antibacterial and anti-inflammatory effects, and can effectively reduce the level of the proinflammatory factor interleukin IL-1lalpha, thereby preventing and repairing keratinocyte inflammation, accelerating the healing of skin wounds, promoting metabolism and delaying skin aging.

The present invention in a preferred example may be further configured to: the ingredients of the age-defending repair cream also comprise the following ingredients in percentage by mass:

2.28% -6.93% of a skin conditioner;

the skin conditioner is one or more of p-hydroxyacetophenone, 1-methylhydantoin-2-imide, acetylated sodium hyaluronate, ceramide 1, ceramide 3, ceramide 6II, phytosphingosine, cholesterol, cyanocobalamine, glycerophosphoinositide choline salt, caprylhydroxamic acid and glyceryl caprylate.

By adopting the technical scheme, the p-hydroxyacetophenone is added, so that the p-hydroxyacetophenone can effectively remove the oxidation free radicals, has a good antioxidant effect, can calm and relieve, reduces the stimulation of the external environment to the skin, has a good antiseptic effect, is mild, is not easy to stimulate the skin, and can effectively prolong the service life of the product;

by adding 1-methylhydantoin-2-imide and 1-methylhydantoin-2-imide, the skin can be helped to improve metabolism, the capillary permeability is enhanced, and epidermal cell groups are helped to be renewed, so that excessive keratinization of skin cells is reduced, and the cells are rich in elasticity;

by adding the sodium acetylhyaluronate, the sodium acetylhyaluronate has better capacity of resisting hyaluronidase, so that the loss of hyaluronic acid in the skin is reduced, the skin is helped to lock water, the expression of thioredoxin can be obviously improved, the generation amount of free radicals is reduced, and the antioxidant effect is better;

the skin lipid membrane can be repaired by adding the ceramide 1, so that the skin barrier is relatively stable, the water loss is reduced, and the moisturizing effect is achieved;

by adding the ceramide 3, the ceramide 3 can help the skin to lock moisture, so that the dry and damaged skin can be repaired, and the moisture of the skin is not easy to lose;

by adding the ceramide 6II, the ceramide 6II can help the stratum corneum of the skin to metabolize rapidly, so that the stratum corneum is prevented from accumulating, and the skin is smoother;

by adding phytosphingosine, the phytosphingosine is beneficial to promoting the generation of ceramide in the skin, so that the moisture of the skin is well kept, and the skin becomes moist and tender;

by adding cholesterol, the cholesterol has good permeability, can keep surface moisture, promote skin metabolism, inhibit skin inflammation, and prevent erythema solare and skin aging;

by adding cyanocobalamine, the cyanocobalamine can strengthen blood vessels, relieve inflammation and improve skin premature senility caused by the inflammation;

by adding glycerophosphoinositide choline salt which is a high-activity component extracted from sunflower, the damage of chemical substances to the skin can be resisted, and the generation of allergic inflammation can be prevented;

by adding the caprylyl hydroximic acid, the effect of the caprylyl hydroximic acid on inhibiting bacteria is better, the effect of the caprylyl hydroximic acid on inhibiting bacteria is not easily influenced, and the bacteriostatic effect can be exerted more stably;

by adding the glyceryl caprylate, the carbon chain of the glyceryl caprylate is easy to permeate and adsorb on the lipid part of human skin, so that the skin barrier can be well protected.

The present invention in a preferred example may be further configured to: the skin conditioner comprises the following components in percentage by mass:

by adopting the technical scheme, the components are matched in a specific proportion, so that the skin care effect is better after the components are added, the moisturizing and anti-inflammatory effects on the skin are better, and the skin is kept healthy better.

8% -14.5% of an emollient;

the emollient is one or more of olive fruit unsaponifiable matter, isononyl isononanoate and polydimethylsiloxane.

By adopting the technical scheme, the olive fruit unsaponifiable matter is added, so that the olive fruit unsaponifiable matter can repair skin injury and remove free radicals, and has a good antioxidant effect;

by adding isononyl isononanoate, the isononyl isononanoate has better esterification effect but does not generate greasy feeling, so that the skin can be kept moist;

by adding the polydimethylsiloxane, the polydimethylsiloxane can form a protective film with better waterproof performance, is not easy to generate greasy feeling, and has better glossiness.

The present invention in a preferred example may be further configured to: the emollient is composed of the following components in percentage by mass:

3% -7% of olive fruit unsaponifiable matter;

4% -6% of isononyl isononanoate;

1 to 1.5 percent of polydimethylsiloxane.

By adopting the technical scheme, the components are matched in a specific proportion, so that the effect of moistening the skin by the emollient is better, the scaly skin is better reduced, the appearance of the skin is improved, and the skin is smoother and softer.

0.8 to 1.2 percent of antioxidant.

By adopting the technical scheme, the antioxidant is added, so that the antioxidant can effectively remove free radicals, ensure the physiological function and metabolism of cells and help to delay skin aging;

the antioxidant can adopt tocopherol, astaxanthin, coenzyme Q10, grape polyphenol and the like, and the antioxidant has a good antioxidant effect by adopting the tocopherol, the astaxanthin, the coenzyme Q10 and the grape polyphenol, so that the skin aging delaying effect is good, the components are mild, and the irritation to facial skin is not easy to cause.

The present invention in a preferred example may be further configured to: the preparation method of the Imperial age repairing cream comprises the following steps:

step 1), mixing hydrogenated lecithin and a solvent, heating to 83-88 ℃, and stirring until the hydrogenated lecithin is completely dissolved to obtain a first mixture;

step 2), mixing and heating glycerol stearate citrate, polyglycerol-3-methyl glucose distearate and phytosterol oleate, and stirring until the polyglycerol-3-methyl glucose distearate, the glycerol stearate citrate and the phytosterol oleate are completely dissolved to obtain a second premix;

step 3), uniformly mixing the second pre-mixture and the first mixture to obtain a second mixture;

step 4), adding sodium lauroyl lactylate into the second mixture, uniformly stirring, and keeping the temperature at 83-88 ℃ for 28-32 minutes to obtain a third mixture;

and 5) cooling the third mixture to 40 ℃ or below, adding the yeast fermentation product filtrate and the buddleja officinalis extract into the third mixture, and uniformly stirring to obtain the imperial-age repair cream.

By adopting the technical scheme, the hydrogenated lecithin is mixed with the solvent, then the mixture is heated to 83-88 ℃, and the mixture is stirred until the hydrogenated lecithin is completely dissolved, so that the hydrogenated lecithin is uniformly dispersed in the solvent, and the emulsification effect of the hydrogenated lecithin on the solvent is better;

the glycerol stearate citrate, the polyglycerol-3-methyl glucose distearate and the phytosterol oleate are mixed and heated, and stirred until the polyglycerol-3-methyl glucose distearate, the glycerol stearate citrate and the phytosterol oleate are completely dissolved, so that the compatibility among the polyglycerol-3-methyl glucose distearate, the glycerol stearate citrate and the phytosterol oleate is better, and the mixing effect after dissolution is better;

by uniformly mixing the second pre-mixture and the first mixture, the interfacial tension of each component in a solvent is further reduced after the hydrogenated lecithin, the polyglycerol-3 methyl glucose distearate and the glycerol stearate citrate are mixed, so that the mixing effect of each component is better;

by adding the sodium lauroyl lactylate into the second mixture and uniformly stirring, the interfacial tension between each component in the second mixture and the solvent is further reduced, each component is further dispersed, and the mixing effect is better;

keeping the temperature at 83-88 ℃ for 28-32 minutes to ensure that the air in the second mixture is discharged through molecular heat movement under the stirring action, so that the air content in the second mixture is reduced, and the influence of the air on the dispersion of each component is reduced;

the third mixture is cooled to 40 ℃ or below, then the yeast fermentation product filtrate and the buddleja officinalis extract are added into the third mixture, and the mixture is uniformly stirred, so that the active ingredients in the yeast fermentation product filtrate and the buddleja officinalis extract are not easily damaged by high temperature, and the complete activity of the yeast fermentation product filtrate and the buddleja officinalis extract is kept, and the yeast fermentation product filtrate and the buddleja officinalis extract are favorable for exerting respective effects.

The present invention in a preferred example may be further configured to: in the step 1), glycerol, 1, 3-propylene glycol, creatine, p-hydroxyacetophenone, 1-methylhydantoin-2-imide and hyaluronic acid are also added into a solvent, heated to 83-88 ℃, and stirred until all the components are completely dissolved;

in the step 2), adding angular squalane, polydimethylsiloxane, olive fruit unsaponifiable matter, meadowfoam-lactone, isononyl isononanoate and antioxidant into glycerol stearate, citric acid ester, polyglycerol-3-methyl glucose distearate and phytosterol oleate, and stirring until the mixture is completely dissolved;

in the step 4), adding ceramide 1, ceramide 3, ceramide 6II, phytosphingosine and cholesterol into the second mixture, uniformly stirring, keeping the temperature at 83-88 ℃ for 28-32 minutes, reducing the temperature to 68-72 ℃, then adding bisabolol, and uniformly stirring to obtain a third mixture;

in the step 5), hydrolyzed hyaluronic acid, hypecoum vulgare callus culture filtrate, glycerophosphoinositide choline salt, cyanocobalamine, caprylyl hydroximic acid and glycerol caprylate are also added into the third mixture and stirred uniformly.

By adopting the technical scheme, the solvent is also added with glycerol, 1, 3-propylene glycol, creatine, p-hydroxyacetophenone, 1-methylhydantoin-2-imide, hyaluronic acid and hydrogenated lecithin, so that the interfacial tension of each component in the solvent is reduced, the solubility of each component in the solvent is increased, and the mixing effect of the components is better;

the preparation method comprises the following steps of adding angular squalane, polydimethylsiloxane, olive fruit unsaponifiable matter, meadowfoam-lactone, isononyl isononanoate and an antioxidant into glycerol stearate citrate, polyglycerol-3-methyl glucose distearate and phytosterol oleate, and stirring until the components are completely dissolved, wherein the compatibility of the components is better, so that the mixing effect of the components after mixing and dissolving is better;

adding ceramide 1, ceramide 3, ceramide 6II, phytosphingosine and cholesterol into the second mixture, and uniformly stirring, wherein the interfacial tension of each substance and the solvent is further reduced by the sodium lauroyl lactylate, so that the dissolving effect of each substance in the second mixture is better;

the temperature is reduced to 68-72 ℃, then the bisabolol is added and stirred uniformly, so that the solubility of the bisabolol in the second mixture is better, and the active ingredients of the bisabolol are not easy to damage due to the reduction of the temperature;

the hydrolyzed hyaluronic acid, the hypecoum vulgare callus culture filtrate, the glycerophosphoinositide choline salt, the cyanocobalamine, the caprylyl hydroximic acid and the glycerol caprylate are also added into the third mixture and are uniformly stirred, so that the active ingredients of the components are not easily damaged, and the components can better exert respective effects.

In summary, the invention includes at least one of the following beneficial technical effects:

1. the product has anti-aging effects in different aspects by adding the phytosterol oleate, the yeast fermentation product filtrate and the buddleja officinalis extract, and the phytosterol oleate can also better relieve the inhibition effect between the yeast fermentation product and the buddleja officinalis extract, so that the anti-aging effect of the product is better;

2. by adding the chinaroot lily-lactone and the hypsizygus marmoreus callus culture filtrate, water loss can be prevented, fibroblast proliferation and collagen growth can be activated, moisture can be effectively preserved, and the skin damage caused by pollution in daily life can be effectively resisted;

3. by adding the antioxidant, the antioxidant can effectively eliminate free radicals, ensure the physiological function and metabolism of cells and help to delay skin aging;

4. the skin moistening effect of the emollient is better through the specific proportion of the unsaponifiable matter, isononyl isononanoate and polydimethylsiloxane, so that the scaly skin is better reduced, the appearance of the skin is improved, and the skin is smoother and softer.

Drawings

FIG. 1 is a schematic flow diagram illustrating a method of making an anti-aging treatment cream according to the present invention.

Detailed Description

The present invention will be described in further detail with reference to the accompanying drawings.

In the following examples and comparative examples, the information on the source of each raw material is shown in Table 1.

TABLE 1

Examples 1 to 3

The anti-aging repair cream comprises the following components

The yeast fermentation product filtrate, the buddleja officinalis extract, phytosterol oleate, hydrogenated lecithin, glycerol stearate citrate, polyglycerol-3-methyl glucose distearate, sodium lauroyl lactylate and a solvent.

The solvent is water.

In examples 1-3, the amounts (in Kg) of each component added are specified in Table 2

TABLE 2

Referring to fig. 1, the preparation method of the Imperial age repairing cream of examples 1-3 includes the following steps:

step 1), adding hydrogenated lecithin and water into a first stirring kettle at a rotating speed of 60r/min, heating to 85 ℃ while stirring, and continuously stirring until the hydrogenated lecithin is completely dissolved to obtain a first mixture;

step 2), putting the glycerol stearate citrate, the polyglycerol-3-methyl glucose distearate and the phytosterol oleate into a second stirring kettle at a rotation speed of 120r/min, heating while stirring until the polyglycerol-3-methyl glucose distearate, the glycerol stearate citrate and the phytosterol oleate are completely dissolved, and discharging into a container to obtain a second premix; (ii) a

Step 3), adding the second pre-mixture into the first mixture, stirring for 3min at the rotating speed of 60r/min, and uniformly mixing to obtain a second mixture;

step 4), adding sodium lauroyl lactylate into the second mixture, stirring at the rotating speed of 60r/min for 3min, uniformly stirring, and keeping the temperature at 85 ℃ for 30min to obtain a third mixture;

and 5) cooling the third mixture to 40 ℃ or below, adding the yeast fermentation product filtrate and the buddleja officinalis extract into the third mixture, stirring at the rotating speed of 60r/min for 3min, and uniformly stirring to obtain the imperial-age repair cream.

Example 4

Compared with example 2, the difference is only that:

in step 1), water was mixed with hydrogenated lecithin and heated to 88 ℃.

In step 4), the temperature is maintained at 88 ℃ for 32min, and then the temperature is reduced to 72 ℃.

In step 5), the third mixture was cooled to 39 ℃.

Example 5

Compared with example 2, the difference is only that:

in step 1), water was mixed with hydrogenated lecithin and heated to 83 ℃.

In step 4), the temperature is maintained at 83 ℃ for 28min, and then the temperature is reduced to 68 ℃.

In step 5), the third mixture was cooled to 38 ℃.

Examples 6 to 8

Compared with example 2, the difference is only that:

the ingredients of the Imperial age repairing cream also comprise:

potentilla chinensis lactone and hypsizygus marmoreus callus culture filtrate

In examples 6 to 8, the amounts (in Kg) of the respective components added are specified in Table 3

TABLE 3

The chinaroot greenbrier lactone is put into a second stirring kettle together with the glycerol stearate citrate, the polyglycerol-3-methyl glucose distearate and the phytosterol oleate in the step 2), and is stirred uniformly.

Adding the hypecoum vulgare callus culture filtrate, the yeast fermentation product filtrate and the buddleja officinalis extract into the third mixture in the step 5), and uniformly stirring.

Examples 9 to 11

Compared with example 2, the difference is only that:

the ingredients of the Imperial age repairing cream also comprise:

squalane, bisabolol.

In examples 9 to 11, the amounts (in Kg) of the respective components added are specified in Table 4

TABLE 4

And (3) adding squalane, glycerol stearate, citric acid ester, polyglycerol-3-methyl glucose distearate and phytosterol oleate into a second stirring kettle in the step 2), and uniformly stirring.

Preserving heat of bisabolol at 85 ℃ for 30min in the step 4), cooling to 70 ℃, adding, stirring at a rotation speed of 60r/min for 3min, and mixing uniformly to obtain a third mixture.

Examples 12 to 14

Compared with example 2, the difference is only that:

the ingredients of the Imperial age repairing cream also comprise:

a skin conditioner.

In examples 12 to 14, the amounts (in Kg) of the respective components added are specified in Table 5

TABLE 5

P-hydroxyacetophenone, 1-methylhydantoin-2-imide and acetylated hyaluronic acid are added into the first stirring kettle together with hydrogenated lecithin and water in the step 2) and stirred until completely dissolved.

Ceramide 1, ceramide 3, ceramide 6II, phytosphingosine and cholesterol are added into the second mixture together with the sodium lauroyl lactylate in the step 4), and the mixture is stirred uniformly.

Cyanocobalamin, glycerophosphoinositide choline salt, caprylhydroxamic acid and glyceryl caprylate are added into the third mixture together with the yeast fermentation product filtrate and the buddleja officinalis extract in the step 5) and stirred uniformly.

Examples 15 to 17

Compared with example 2, the difference is only that:

the ingredients of the Imperial age repairing cream also comprise:

an emollient.

The emollient is the compound of olive fruit unsaponifiable matter, isononyl isononanoate and polydimethylsiloxane.

In examples 15 to 17, the amounts (in Kg) of the respective components added are specified in Table 6

TABLE 6

The olive fruit unsaponifiable matter, the polydimethylsiloxane and the isononyl isononanoate are put into a second stirring kettle together with the glycerol stearate citrate, the polyglycerol-3-methyl glucose distearate and the phytosterol oleate in the step 2) and are stirred uniformly.

Examples 18 to 20

Compared with example 2, the difference is only that:

the ingredients of the Imperial age repairing cream also comprise:

an antioxidant.

The antioxidant is tocopherol.

In examples 18 to 20, the amounts (in Kg) of the respective components added are specified in Table 7

TABLE 7

The tocopherol, the glycerol stearate citrate, the polyglycerol-3-methyl glucose distearate and the phytosterol oleate are put into a second stirring kettle together in the step 2) and are stirred uniformly.

Examples 21 to 23

Compared with example 2, the difference is only that:

the ingredients of the Imperial age repairing cream also comprise:

a humectant.

The humectant is a compound of glycerol, 1, 3-propylene glycol, creatine, hydrolyzed hyaluronic acid and 1, 2-pentanediol.

In examples 21 to 23, the amounts (in Kg) of the respective components added are specified in Table 8

TABLE 8

The glycerol, the 1, 3-propylene glycol and the creatine are put into a second stirring kettle together with the hydrogenated lecithin in the step 1) and are stirred uniformly.

Adding hydrolyzed hyaluronic acid and 1, 2-pentanediol into the third mixture in step 5), and mixing with yeast fermentation product filtrate and flos Buddlejae extract, and stirring.

Examples 24 to 26

Compared with example 2, the difference is only that:

the ingredients of the Imperial age repairing cream also comprise:

chelating agent, thickening agent, preservative and essence.

The chelating agent is EDTA disodium;

the thickening agent is a compound of acryloyl dimethyl ammonium taurate/VP copolymer, cetostearyl alcohol, carbomer and xanthan gum;

the preservative is the compound of methylparaben and ethylparaben.

In examples 24 to 26, the amounts (in Kg) of the respective components charged are shown in Table 9

TABLE 9

Disodium EDTA and the acryloyl dimethyl ammonium taurate/VP copolymer are put into a second stirring kettle together with the hydrogenated lecithin in the step 1) and stirred uniformly.

The cetearyl alcohol, the glyceryl stearate citrate, the polyglyceryl-3-methylglucose distearate and the phytosterol oleate are put into a second stirring kettle together in the step 2) and stirred uniformly.

Methyl hydroxybenzoate, ethylparaben, carbomer and xanthan gum are added into the second mixture in the step 4) together with the sodium lauroyl lactylate, and are stirred uniformly.

Adding the essence, the yeast fermentation product filtrate and the buddleja officinalis extract into the third mixture in the step 5), and uniformly stirring.

Examples 27 to 29

Compared with example 2, the difference is only that:

the ingredients of the Imperial age repairing cream also comprise:

potentilla chinensis lactone, hypsizygus marmoreus callus culture filtrate, squalane, bisabolol, skin conditioner, emollient, antioxidant, humectant, chelating agent, thickener, antiseptic, and essence.

The skin conditioner is one or more of p-hydroxyacetophenone, 1-methylhydantoin-2-imide, acetylated sodium hyaluronate, ceramide 1, ceramide 3, ceramide 6II, phytosphingosine, cholesterol, cyanocobalamine, glycerophosphoinositide choline salt, caprylyl hydroximic acid and glyceryl caprylate;

the emollient is one or more of olive fruit unsaponifiable matter, isononyl isononanoate and polydimethylsiloxane;

the antioxidant is tocopherol;

the humectant is a compound of glycerol, 1, 3-propylene glycol, creatine, hydrolyzed hyaluronic acid and 1, 2-pentanediol;

the chelating agent is EDTA disodium;

the preservative is the compound of methylparaben and ethylparaben.

In examples 27-29, the amounts (in Kg) of each component charged are specified in Table 10

Watch 10

Glycerin, 1, 3-propylene glycol, creatine, disodium EDTA, and an acryloyl dimethyl taurate/VP copolymer are put into the second stirring vessel together with the hydrogenated lecithin in step 1), and stirred uniformly.

The method comprises the following steps of putting the chinaroot-lactone, squalane, p-hydroxyacetophenone, 1-methylhydantoin-2-imide, acetylated hyaluronic acid, olive unsaponifiable matter, polydimethylsiloxane, isononyl isononanoate, tocopherol and cetostearyl alcohol in the step 2) and glycerol stearate, citric acid ester, polyglycerol-3 methyl glucose distearate and phytosterol oleate into a second stirring kettle, and uniformly stirring.

Ceramide 1, ceramide 3, ceramide 6II, phytosphingosine, cholesterol, methylparaben, ethylparaben, carbomer and xanthan gum are added into the second mixture together with sodium lauroyl lactylate in the step 4), the mixture is uniformly stirred, the temperature of bisabolol is kept at 85 ℃ for 30min, the temperature is reduced to 70 ℃, the mixture is added, the rotating speed is 60r/min, the mixture is stirred for 3min, and the mixture is uniformly mixed to obtain a third mixture.

Adding the hypecoum culture filtrate, cyanocobalamine, glycerophosphoinositide choline salt, caprylyl hydroximic acid, glycerol caprylate, hydrolyzed hyaluronic acid, 1, 2-pentanediol and essence in the step 5), the yeast fermentation product filtrate and the buddleja officinalis extract into the third mixture, and uniformly stirring.

Comparative example 1

Compared with example 2, the difference is only that:

in the step 2), the yeast fermentation product filtrate, the buddleja officinalis extract and the phytosterol oleate are replaced by the same amount of water.

Comparative example 2

Compared with example 2, the difference is only that:

in the step 2), the buddleja officinalis extract and the phytosterol oleate are replaced by the same amount of water.

Comparative example 3

Compared with example 2, the difference is only that:

in the step 2), the yeast fermentation product filtrate and the phytosterol oleate are replaced by equal amount of water.

Comparative example 4

Compared with example 2, the difference is only that:

in the step 2), the yeast fermentation product filtrate and the buddleja officinalis extract are replaced by the same amount of water.

Comparative example 5

Compared with example 2, the difference is only that:

in the step 2), the yeast fermentation product filtrate is replaced by equal amount of water.

Comparative example 6

Compared with example 2, the difference is only that:

in step 2), the same amount of water is used to replace the extract of the buddleja officinalis.

Comparative example 7

Compared with example 2, the difference is only that:

in the step 2), the phytosterol oleate is replaced by the same amount of water.

Experiment 1

XTT is a tetrazole nitrogen derivative, can be degraded and reduced into water-soluble brown yellow formazan products by mitochondrial dehydrogenase in living cells, and the generation amount of the formazan is positively correlated with the activity of cell mitochondria, so that the XTT method can be used for detecting the activity of the mitochondria so as to react the metabolic capability of the cells.

Inoculating human immortalized keratinocyte (HaCaT) cells in a limiting keratinocyte serum-free medium (DK-SFM) at 37 deg.C in CO₂Culturing in a constant temperature incubator with volume fraction of 5% for 5 days until cells are fused, and changing culture solution every other day. For the experiment, the cell culture bottle was taken out, the HaCaT cells were digested with trypsin for 4min, and then the cells were inoculated and incubated with 96-well plates for 24h, 200 μ L of the anti-aging cream prepared in each example and comparative example with a solid content of 0.1mg/mL diluted with DK-SFM medium was added to each well, and the measurement was performed after 48h in the incubator. XTT was dissolved in a 0.2mg/mL solution by preheating at 60 ℃ and the cell culture medium in a 96-well plate was removed, XTT/PMS (200:1) (PMS means phenazine methosulfate) was added to each well, followed by incubation at 37 ℃ for 2h and measurement of the absorbance OD at a wavelength of 450nm on a microplate reader according to the absorbance 0D measured in comparative example 1₀As a reference value, the ratio of mitochondrial activity to OD/0D was obtained by dividing the absorbance of each example or each comparative example by the absorbance of comparative example 1 and multiplying by 100%₀The absorbance 0D of comparative example 1 was subtracted from the absorbance OD of each example or each comparative example by calculation₀The boosted value is obtained, and the boosted value is divided by the light absorption value 0D of each example or each comparative example and multiplied by 100%, so that the boosting ratio is obtained.

Experiment 2

DPPH radical scavenging Rate experiment

Taking 1, 1-diphenyl-2-picrylhydrazine (DPPH) -anhydrous methanol solution with the concentration of 3mL0.0178mmol/L, adding 3mL of solution to be detected prepared from Yu-Ning repair cream prepared in each example and comparative example, uniformly mixing, immediately measuring the absorbance at the wavelength of 517nm, wherein the absorbance is marked as A1, then measuring the absorbance after storing in dark for 30min at 37 ℃, and is marked as A2, the blank control group is prepared by only adding DPPH-anhydrous methanol solution, the absorbance is marked as A3, and the DPPH free radical scavenging rate is calculated according to the following formula: DPPH free radical clearance (%) [1- (a1-a2)/A3] × 100%, and an average of three measurements was taken.

Experiment 3

The test method comprises the following steps: 180 adult female volunteers, aged between 30-40 years, were divided into 36 groups of 5 individuals each. Each imperial repair cream prepared in each example and comparative example was applied to the face after cleansing the face every morning and evening, and the value of the skin moisture loss in the cheek region was measured using a Tewameter TM300 after 1 day, 1 week and 2 weeks of continuous use, and the skin moisture loss was measured in a state where the skin was dry and without sweat at an ambient temperature of 21 ℃ and an ambient humidity of 50%. The percutaneous water loss well reflects the integrity of the skin barrier function, the percutaneous water loss value is improved, which indicates that the skin water diffusion is increased, and conversely, the percutaneous water loss value is reduced, which indicates that the skin barrier is repaired.

The data from experiments 1-3 are detailed in Table 11

TABLE 11

According to the data in the table 11, the imperial age repair cream prepared by each example meets the standard and has better quality.

According to the comparison of the data of comparative example 2 and comparative example 1 in table 11, after the yeast fermentation product filtrate is added, the mitochondrial activity is improved compared with the free radical clearance rate, and the yeast fermentation product filtrate is proved to have the effect of accelerating metabolism and scavenging free radicals, and the percutaneous water loss is gradually reduced, and the yeast fermentation product filtrate is proved to have a better skin barrier repairing effect, so that the moisture loss of the skin is reduced, the moisturizing capability is improved, and the anti-aging effect is better.

According to the comparison of the data of comparative example 3 and comparative example 1 in table 11, the radical scavenging rate is obviously increased after the buddleja officinalis extract is added, and the buddleja officinalis extract is proved to have better capacity of scavenging radicals, and the percutaneous water loss is slightly reduced, which indicates that the buddleja officinalis extract has no obvious effect of repairing the skin barrier and has certain anti-aging effect.

According to the comparison of the data of comparative example 4 and comparative example 1 in table 11, after the phytosterol oleate is added, the mitochondrial activity is higher than that of the free radical clearance, and the results prove that the phytosterol oleate has certain effects of accelerating metabolism and improving the free radical clearance, and the transdermal water emission is reduced, so that the phytosterol oleate can repair skin barriers to a certain extent, enhance the skin moisturizing capability and have certain anti-aging effect.

As can be seen from comparison of the data in Table 11 in comparative example 5 and comparative example 3, the radical scavenging rate was significantly improved and the skin moisture loss was reduced to some extent by adding phytosterol oleate, which demonstrates that the combination of phytosterol oleate and the extract of Buddleja officinalis exhibited better antioxidant effect, increased skin moisturizing ability and improved anti-aging effect.

According to the comparison of the data of comparative example 6 and comparative example 2 in table 11, after the phytosterol oleate is added, the mitochondrial activity ratio is obviously improved, which proves that the metabolism speed is accelerated, the free radical clearance is improved to a certain degree, which proves that the antioxidant effect is enhanced to a certain degree, the percutaneous water loss is gradually reduced, the skin moisturizing capability is enhanced, and the anti-aging effect is better.

As can be seen from comparison of the data in table 11 in comparative example 7 and comparative example 2, after the buddleja officinalis extract was added, the mitochondrial activity was decreased, the metabolism was slowed, the transdermal water loss was increased, it was proved that the skin barrier could not be well repaired, the water loss of the skin was still fast, it was proved that the buddleja officinalis extract had an inhibitory effect on the metabolism of the yeast fermentation product filtrate and the barrier for repairing the skin, so that the anti-aging effect was deteriorated.

As can be seen from comparison of the data of comparative example 7 and comparative example 3 in table 11, the radical scavenging rate did not change significantly and the change of the transdermal water loss was small with the increase of time after the yeast fermentation product filtrate was added, demonstrating that the yeast fermentation product filtrate has an inhibitory effect on the improvement of the radical scavenging rate and the barrier repairing effect of the buddleja officinalis extract, so that the anti-aging effect was poor.

As can be seen from comparison of the data of example 2 and comparative example 7 in table 11, by adding phytosterol oleate, the mitochondrial activity ratio and the radical scavenging rate are increased, the speed of metabolism and the antioxidant effect are proved to be better, the moisture loss through skin is reduced, the skin barrier is proved to be better repaired, the moisturizing capability of the skin is enhanced, the phytosterol oleate relieves the inhibition effect of the yeast fermentation product and the buddleja officinalis extract on the aspects of metabolism and skin barrier repair, the radical scavenging rate effect is further improved, the antioxidant effect is better, and the multiple anti-aging effect is better.

As can be seen from comparison of the data in example 2 and comparative example 6 in table 11, the radical scavenging rate was significantly improved by adding the buddleja officinalis extract, which proves that the antioxidant effect was further enhanced, the skin moisture loss was alleviated to some extent, and the buddleja officinalis extract was proved to have a better skin barrier repair effect and a better multiple anti-aging effect.

According to the comparison of the data of example 2 and comparative example 5 in table 11, the addition of the yeast fermentation product filtrate significantly increases the radical scavenging rate, and proves that the antioxidant effect is enhanced, and the transdermal water loss is significantly reduced, which indicates that the skin barrier is better repaired, and the multiple anti-aging effect is more significant.

As can be seen from the comparison of the data of examples 4 and 5 with example 2 in table 11, the mixing of the composition at a specific temperature and the retention for a specific time at a specific temperature makes the components of the imperial age repairing cream more uniformly mixed, thereby making the effect of the imperial age repairing cream more stable.

According to comparison of the data of examples 6-8 and example 2 in table 11, the addition of the clidanactone and hypsizygus marmoreus callus culture filtrate further accelerates the metabolism rate, enhances the radical clearance rate, remarkably repairs the skin barrier, enhances the skin moisturizing ability, and easily maintains the skin in a better state, thereby achieving a better multiple anti-aging effect.

As can be seen from a comparison of the data in Table 11 in examples 9-11 with example 2, the addition of squalane and bisabolol reduced the loss of moisture through the skin, and resulted in better skin barrier repair and multiple anti-aging effects.

As can be seen from a comparison of the data in Table 11 for examples 12-14 with example 2, the metabolism and the radical clearance are further enhanced and the skin barrier is better repaired by adding the skin conditioner, resulting in a further improvement of the multiple anti-aging effect.

As can be seen from a comparison of the data in Table 11 for examples 15-17 with example 2, the incorporation of emollients results in a reduction in the loss of moisture through the skin, a reduction in the loss of moisture from the skin, an increase in the moisturizing ability of the skin, and a greater multiple anti-aging effect.

As can be seen from comparison of the data of examples 18 to 20 with example 2 in Table 11, the radical scavenging rate is significantly improved by adding the antioxidant, so that the antioxidant effect is better, and thus the multiple antiaging effect is better.

As can be seen from comparison of the data in Table 11 for examples 21-23 with example 2, the skin moisture is not easily lost by the addition of moisturizers, resulting in better skin moisturizing ability and anti-aging effect.

The embodiments of the present invention are preferred embodiments of the present invention, and the scope of the present invention is not limited by these embodiments, so: all equivalent changes made according to the structure, shape and principle of the invention are covered by the protection scope of the invention.

Claims

1. The age-defending repair cream is characterized in that: the paint mainly comprises the following components in percentage by mass:

0.5 to 1.5 percent of yeast fermentation product filtrate;

0.1 to 1 percent of buddleja officinalis extract;

1% -2% of phytosterol oleate;

0.8% -1.2% of hydrogenated lecithin;

1% -2% of glycerol stearate citrate;

2% -3% of polyglycerol-3-methylglucose distearate;

0.05 to 0.15 percent of sodium lauroyl lactylate;

the balance of solvent;

the total mass percentage is 100 percent.

2. The imperial age repair cream of claim 1, wherein: the Imperial age repairing cream also comprises the following components in percentage by mass:

0.2 to 0.8 percent of chinaroot greenbrier herb-lactone;

the hypecoum vulgare callus culture filtrate is 0.08-0.12%.

3. The imperial age repair cream of claim 1, wherein: the Imperial age repairing cream also comprises the following components in percentage by mass:

3% -5% of squalane;

0.1 to 0.3 percent of bisabolol.

4. The imperial age repair cream of claim 1, wherein: the Imperial age repairing cream also comprises the following components in percentage by mass:

2.28% -6.92% of a skin conditioner;

5. The imperial age repair cream of claim 4, wherein: the skin conditioner comprises the following components in percentage by mass:

0.1 to 0.5 percent of p-hydroxyacetophenone;

0.1 to 0.3 percent of acetylated sodium hyaluronate;

10.08% -0.12% of ceramide;

30.4% -0.8% of ceramide;

0.3 to 0.7 percent of ceramide 6 II;

phytosphingosine 0.1% -0.5%;

0.2% -0.6% of cholesterol;

cyanocobalamin 0.2% -0.7%;

0.1% -0.7% of glycerophosphoinositide choline salt;

0.1% -0.3% of caprylyl hydroximic acid;

0.1% -0.2% of glycerol caprylate;

0.5 to 1.5 percent of 1-methylhydantoin-2-imide.

6. The imperial age repair cream of claim 1, wherein: the Imperial age repairing cream also comprises the following components in percentage by mass:

8% -14.5% of an emollient;

7. The imperial age repair cream of claim 6, wherein: the emollient is composed of the following components in percentage by mass:

3% -7% of olive fruit unsaponifiable matter;

4% -6% of isononyl isononanoate;

1 to 1.5 percent of polydimethylsiloxane.

8. The imperial age repair cream of claim 1, wherein: the Imperial age repairing cream also comprises the following components in percentage by mass:

0.8 to 1.2 percent of antioxidant.

9. A method of preparing the Imperial age-correcting cream of claim 1, wherein the method comprises the steps of: the preparation method of the Imperial age repairing cream comprises the following steps:

10. The method of preparing an imperial age repair cream according to claim 9, wherein: in the step 1), glycerol, 1, 3-propylene glycol, creatine, p-hydroxyacetophenone, 1-methylhydantoin-2-imide and hyaluronic acid are also added into a solvent, heated to 83-88 ℃, and stirred until all the components are completely dissolved;