CN115607638A - Traditional Chinese medicine composition for infantile indigestion with food retention and preparation method thereof - Google Patents
Traditional Chinese medicine composition for infantile indigestion with food retention and preparation method thereof Download PDFInfo
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Abstract
The invention provides a traditional Chinese medicine composition for infantile indigestion with food retention and a preparation method thereof, relating to the technical field of traditional Chinese medicines, and the traditional Chinese medicine composition for infantile indigestion with food retention comprises the following raw materials: eugenol, fructus Hordei Germinatus, mume fructus, fructus oryzae Germinatus, dioscin, allantoin, quercetin, hyperoside, oligomeric procyanidin, hesperidin, nobiletin, and hesperetin. The traditional Chinese medicine composition has accurate dosage of each component, and can safely and effectively treat infantile indigestion with food retention.
Description
Technical Field
The invention relates to the technical field of traditional Chinese medicines, and in particular relates to a traditional Chinese medicine composition for treating infantile indigestion with food retention and a preparation method thereof.
Background
Food stagnation in children is also called accumulation stagnation, is a syndrome of spleen and stomach, is usually seen in children of all ages, especially infants, has no obvious symptoms in early stage, and most of the diseases directly show typical symptoms, such as abdominal discomfort, abdominal pain, heartburn or anorexia. Unlike indigestion caused mainly by stomach power deficiency, the principal drug for infantile indigestion is retained in the intestines and stomach due to excessive intake of food, thereby damaging the intestines and stomach to cause gastrointestinal diseases. In the treatment of infantile indigestion with food retention, the common treatment method comprises the adjustment of life style and eating habits or the medicine intervention treatment, wherein the medicine treatment comprises the administration of prokinetic drugs, antacid drugs and acid inhibitor drugs or drugs for eradicating Hp infection, and the dialectical treatment by using traditional Chinese medicines (plus or minus spleen-tonifying pills, plus or minus health-preserving pills and the like) is supplemented with the methods of massage, acupuncture, spine-pinching and the like.
Among a plurality of treatment methods aiming at infantile indigestion with food retention, the traditional Chinese medicine is safe in treatment, has small side effect, does not damage gastrointestinal tracts, and is widely applied and researched. For example: the literature is as follows: liu 32766, wei, comprehensive nursing experience of traditional Chinese medicine for treating infantile indigestion, 2016 (1) and 1, which disclose a traditional Chinese medicine treatment method using 10g of endothelium corneum gigeriae galli, 10g of medicated leaven, 10g of malt, 10g of scorched hawthorn fruit, 6g of radish seed, 6g of dried orange peel, 12g of poria cocos, 6g of pinellia ternate, 6g of fried fructus aurantii and 6g of costustoot. As further documented: the four-grinding decoction (combined spicebush root, areca seed, costus root and bitter orange) is adopted to treat the infantile indigestion, and the prescription is suitable for abdominal distension, abdominal pain, crying uneasiness, anorexia, diarrhea or constipation caused by infantile indigestion and functional dyspepsia of children. Also, the article refers to the use of Simotang oral liquid in combination with anti-hepatitis-jaundice particles, live clostridium butyricum powder or pills for treating other disorders (e.g. neonatal jaundice, malnutrition or gastrointestinal dysfunction).
The existing commercial related products such as the children's stomach invigorating oral liquid comprise clove, hawthorn, malt, rice sprout, dark plum and the like as main components, can invigorate the spleen and nourish the stomach, regulate qi and promote digestion, and can be used for treating anorexia, abdominal distension, eructation and abdominal pain caused by infantile anorexia and indigestion. The related patent CN1857414A discloses that clove is used for extracting clove volatile oil, and then 300 parts of Chinese yam, 360 parts of hawthorn, 300 parts of malt, 125 parts of dried orange peel, 180 parts of dark plum, 300 parts of rice sprout and the like are matched with the extracted herb residue, and the extracted herb residue is extracted and filtered together to obtain a filtrate, and the filtrate is mixed with clove volatile oil to obtain the medicine with the functions of strengthening spleen, benefiting stomach, eliminating stagnation and enhancing appetite.
However, the current research mainly aims at the compatibility of clove and other medicines, or the extraction of volatile oil of clove, and the further combination of other medicines, so as to obtain a product with curative effect on infantile indigestion with food retention, or aim at the combined use of related traditional Chinese medicine preparation and other medicines to treat other diseases. However, the research on other related medicines and extracts thereof is not deeply carried out, so the research is still blank, but the treatment means with more pertinence, safety and better effect is still needed for the infantile indigestion. In order to solve the problems, relevant research is carried out, and therefore a more targeted composition with excellent effect is required to be found for treating infantile indigestion.
Disclosure of Invention
The invention provides a traditional Chinese medicine composition for treating infantile indigestion with food retention and a preparation method thereof, aiming at the problems in the prior art, the composition has accurate dosage of each component, and can safely and effectively treat infantile indigestion with food retention.
In order to achieve the purpose, the technical scheme adopted by the invention is as follows:
the invention provides a traditional Chinese medicine composition for infantile indigestion with food retention, which comprises the following raw materials: eugenol, fructus Hordei Germinatus, mume fructus, fructus oryzae Germinatus, dioscin, allantoin, quercetin, hyperoside, oligomeric procyanidin, hesperidin, nobiletin, and hesperetin.
Further, the traditional Chinese medicine composition comprises the following raw materials in parts by weight: 60-68 parts of eugenol, 8800-9100 parts of malt, 5300-5500 parts of smoked plum, 8800-9100 parts of rice sprout, 0.2-0.8 part of dioscin, 22-24.5 parts of allantoin, 0.2-0.6 part of quercetin, 1.2-1.5 parts of hyperoside, 100-118 parts of oligomeric proanthocyanidin, 36-40 parts of hesperidin, 9-9.8 parts of nobiletin and 5.5-5.8 parts of hesperetin.
Preferably, the traditional Chinese medicine composition comprises the following raw materials in parts by weight: 66 parts of eugenol, 9000 parts of malt, 5400 parts of dark plum fruit, 9000 parts of rice sprout, 0.55 part of dioscin, 22.5 parts of allantoin, 0.54 part of quercetin, 1.35 parts of hyperin, 108 parts of oligomeric proanthocyanidin, 37.5 parts of hesperidin, 9.37 parts of nobiletin and 5.62 parts of hesperetin.
Further, the weight ratio of the allantoin to the nobiletin is 22-24.5.
Preferably, the weight ratio of allantoin to nobiletin is 22.5.
Further, the invention provides a preparation method of the traditional Chinese medicine composition, which comprises the following steps:
(1) Mixing fructus Hordei Germinatus, mume fructus, and fructus oryzae Germinatus, adding water, extracting, and concentrating to obtain fluid extract;
(2) Adding eugenol, dioscin, allantoin, quercetin, hyperoside, oligomeric procyanidin, hesperidin, nobiletin, and hesperetin into the fluid extract, and mixing.
Further, the water-adding extraction in the step (1) specifically comprises: adding 8-10 times of water, decocting for 1-2 hr, filtering to obtain extractive solution A and residue, adding 5-6 times of water, decocting for 2 hr, filtering to obtain extractive solution B, and mixing extractive solutions A and B.
Preferably, the water-adding extraction in the step (1) specifically comprises: adding 9 times of water, decocting for 2 hr, filtering to obtain extractive solution A and residue, adding 5 times of water, decocting for 2 hr, filtering to obtain extractive solution B, and mixing extractive solutions A and B.
Furthermore, the traditional Chinese medicine composition provided by the invention can be applied to preparation of medicines for treating infantile indigestion with food retention.
Furthermore, the invention also provides a medicine for treating infantile indigestion with food retention, the traditional Chinese medicine composition and medically usable auxiliary materials.
Further, the dosage form of the medicine comprises tablets, capsules, granules, paste, liquid, pills or suspension.
Preferably, the dosage form of the medicament is a liquid.
The technical effects obtained by the invention are as follows:
the invention further develops and utilizes the medicine on the basis of the original children Jianweining oral liquid, and the specific traditional Chinese medicine raw materials comprise malt, dark plum, rice sprout and the like, and are matched with medicinal materials such as clove, chinese yam and the like to extract and compound active ingredients. The dosage is controlled more accurately by utilizing the synergistic effect of the active ingredients, and the pharmaceutical effect is exerted.
The research of the invention finds that the components of the traditional Chinese medicine composition are mutually assisted, particularly the synergistic effect of allantoin and nobiletin is most obvious, the finally obtained traditional Chinese medicine composition can be used for treating infantile indigestion with food retention, and the composition can be used for preparing various preparations by matching with other auxiliary materials, and has better effect and safety compared with the traditional Chinese medicine formula.
Detailed Description
The following embodiments of the present invention are provided by way of specific examples, and other advantages and effects of the present invention will be readily apparent to those skilled in the art from the disclosure herein. The invention is capable of other and different embodiments and of being practiced or of being carried out in various ways, and its several details are capable of modification in various respects, all without departing from the spirit and scope of the present invention.
Before the present embodiments are further described, it is to be understood that the scope of the invention is not limited to the particular embodiments described below; it is also to be understood that the terminology used in the examples herein is for the purpose of describing particular embodiments only, and is not intended to limit the scope of the present invention.
When numerical ranges are given in the examples, it is understood that both endpoints of each of the numerical ranges and any number between the two endpoints are optional unless otherwise specified in the invention. Unless defined otherwise, all technical and scientific terms used herein have the same meaning as commonly understood by one of ordinary skill in the art to which this invention belongs.
It should be noted that the raw materials used in the present invention are all common commercial products, and thus the sources thereof are not particularly limited.
Example 1
A traditional Chinese medicine composition for infantile indigestion with food retention comprises the following raw materials in parts by weight: 60 parts of eugenol, 8800 parts of malt, 5300 parts of smoked plum, 8800 parts of rice sprout, 0.2 parts of dioscin, 22 parts of allantoin, 0.2 parts of quercetin, 1.2 parts of hyperoside, 100 parts of oligomeric procyanidine, 36 parts of hesperidin, 9 parts of nobiletin and 5.5 parts of hesperetin. The preparation method of the traditional Chinese medicine composition comprises the following steps: (1) Mixing malt, dark plum and rice sprout, adding 8 times of water, decocting for 1h, filtering to obtain an extract A and dregs, adding 5 times of water into dregs, decocting for 2h, filtering to obtain an extract B, mixing the extract A and the extract B, and concentrating to obtain a clear paste with a relative density of 1.2 (50 ℃); (2) Adding eugenol, dioscin, allantoin, quercetin, hyperoside, oligomeric procyanidin, hesperidin, nobiletin, and hesperetin into the fluid extract, and mixing.
Example 2
A traditional Chinese medicine composition for infantile indigestion with food retention comprises the following raw materials in parts by weight: 68 parts of eugenol, 9100 parts of malt, 5500 parts of dark plum fruit, 9100 parts of rice sprout, 0.8 part of dioscin, 24.5 parts of allantoin, 0.6 part of quercetin, 1.5 parts of hyperin, 118 parts of oligomeric proanthocyanidin, 40 parts of hesperidin, 9.8 parts of nobiletin and 5.8 parts of hesperetin. The preparation method of the traditional Chinese medicine composition comprises the following steps: (1) Mixing malt, smoked plum and rice sprout, adding water with the volume 10 times of that of the medicinal materials, decocting for 2 hours, filtering to obtain an extracting solution A and decoction dregs, adding water with the volume 6 times of that of the decoction dregs, decocting for 2 hours, filtering to obtain an extracting solution B, combining the extracting solution A and the extracting solution B, and concentrating to obtain a clear paste with the relative density of 1.2 (50 ℃); (2) Adding eugenol, dioscin, allantoin, quercetin, hyperoside, oligomeric procyanidin, hesperidin, nobiletin, and hesperetin into the fluid extract, and mixing.
Example 3
A traditional Chinese medicine composition for infantile indigestion with food retention comprises the following raw materials in parts by weight: 66 parts of eugenol, 9000 parts of malt, 5400 parts of dark plum fruit, 9000 parts of rice sprout, 0.55 part of dioscin, 22.5 parts of allantoin, 0.54 part of quercetin, 1.35 parts of hyperin, 108 parts of oligomeric proanthocyanidin, 37.5 parts of hesperidin, 9.37 parts of nobiletin and 5.62 parts of hesperetin. The preparation method of the traditional Chinese medicine composition specifically comprises the following steps: (1) Mixing malt, dark plum and rice sprout, adding 9 times of water, decocting for 2h, filtering to obtain extract A and dregs, adding 5 times of water, decocting for 2h, filtering to obtain extract B, mixing extract A and extract B, and concentrating to obtain fluid extract with relative density of 1.2 (50 deg.C); (2) Adding eugenol, dioscin, allantoin, quercetin, hyperoside, oligomeric procyanidin, hesperidin, nobiletin, and hesperetin into the fluid extract, and mixing.
Comparative example 1
A traditional Chinese medicine composition for infantile indigestion with food retention comprises the following raw materials in parts by weight: 60 parts of eugenol, 8800 parts of malt, 5300 parts of smoked plum, 8800 parts of rice sprout, 0.2 parts of dioscin, 0.2 parts of quercetin, 1.2 parts of hyperin, 100 parts of oligomeric procyanidin, 36 parts of hesperidin, 31 parts of nobiletin and 5.5 parts of hesperetin. The preparation method of the traditional Chinese medicine composition comprises the following steps: (1) Mixing malt, dark plum and rice sprout, adding 8 times of water, decocting for 1h, filtering to obtain an extract A and dregs, adding 5 times of water into dregs, decocting for 2h, filtering to obtain an extract B, mixing the extract A and the extract B, and concentrating to obtain a clear paste with a relative density of 1.2 (50 ℃); (2) Adding eugenol, dioscin, quercetin, hyperoside, oligomeric procyanidin, hesperidin, nobiletin, and hesperetin into the fluid extract, and mixing.
That is, it is different from example 1 only in that allantoin is replaced with an equal amount of nobiletin.
Comparative example 2
A traditional Chinese medicine composition for infantile indigestion with food retention comprises the following raw materials in parts by weight: 60 parts of eugenol, 8800 parts of malt, 5300 parts of smoked plum, 8800 parts of rice sprout, 0.2 parts of dioscin, 31 parts of allantoin, 0.2 parts of quercetin, 1.2 parts of hyperoside, 100 parts of oligomeric procyanidine, 36 parts of hesperidin and 5.5 parts of hesperetin. The preparation method of the traditional Chinese medicine composition comprises the following steps: (1) Mixing malt, dark plum and rice sprout, adding 8 times of water, decocting for 1h, filtering to obtain an extract A and dregs, adding 5 times of water into dregs, decocting for 2h, filtering to obtain an extract B, mixing the extract A and the extract B, and concentrating to obtain a clear paste with a relative density of 1.2 (50 ℃); (2) Adding eugenol, dioscin, allantoin, quercetin, hyperoside, oligomeric procyanidin, hesperidin, and hesperetin into the fluid extract, and mixing.
That is, it is different from example 1 only in that nobiletin was replaced with allantoin in an equal amount.
Comparative example 3
A traditional Chinese medicine composition for infantile indigestion with food retention comprises the following raw materials in parts by weight: 60 parts of eugenol, 8800 parts of malt, 5300 parts of smoked plum, 8800 parts of rice sprout, 0.2 parts of dioscin, 22 parts of crotch-stopping element, 0.2 parts of quercetin, 1.2 parts of hyperin, 100 parts of oligomeric proanthocyanidin, 36 parts of hesperidin, 9 parts of ursolic acid and 5.5 parts of hesperetin. The preparation method of the traditional Chinese medicine composition specifically comprises the following steps: (1) Mixing malt, dark plum and rice sprout, adding 8 times of water, decocting for 1h, filtering to obtain an extract A and dregs, adding 5 times of water into dregs, decocting for 2h, filtering to obtain an extract B, mixing the extract A and the extract B, and concentrating to obtain a clear paste with a relative density of 1.2 (50 ℃); (2) Adding eugenol, dioscin, zhi su, quercetin, hyperoside, oligomeric procyanidin, hesperidin, ursolic acid, and hesperetin into the fluid extract, and mixing.
Namely, the only difference from example 1 is that allantoin and nobiletin were replaced with equivalent amounts of crotch-inhibiting substance and ursolic acid, respectively.
Evaluation of Effect
The pharmacodynamic experimental study of the traditional Chinese medicine composition for treating infantile indigestion with food retention is carried out, the physiological influence of the traditional Chinese medicine composition on the gastrointestinal motility and gastric secretion of rats and the body quality, abdominal circumference, food intake and stool output of rats is observed, and the treatment effect of the traditional Chinese medicine composition on indigestion with food retention, anorexia and functional dyspepsia is evaluated.
1. Effect on gastrointestinal motility in young rats
1. Experimental Material
1.1 Experimental animals
Weaning (3 weeks old) SD young rats, male, SPF grade, body weight 60-70g; each squirrel cage is hung with an identity card with information such as project numbers, experimental groups, names of experimenters, animal species, sexes and the like, and the tail root of the rat is marked with a line;
the young rats are raised in an animal room at the raising temperature of 23 +/-2 ℃, the relative humidity of 40-70 percent and 12-hour light and shade alternation; animals are raised in 5 cages each time, and padding is replaced twice each week; feeding SPF rat growth and reproduction feed in the adaptation period (3 days); water for experimental animals is filtered by autoclaving; the animals used in the experiment will remain healthy; animals ingest and drink water freely during the experiment;
1.2 Experimental drugs
The tested drugs are: the Chinese medicinal composition (source: jilin Huakang pharmaceutical industry Co., ltd.) in each example of the invention;
positive drug: jianweining oral liquid for children (source: jilin Huakang pharmaceutical industry GmbH; national Standard B20020507; specification: 10 ml/count);
blank control: sterilizing water for injection;
1.3 Experimental reagents
Sodium carboxymethylcellulose (CMC-Na) (viscosity: 800-1200mpa.s, USP grade; specification: 500 g/bottle);
2. experimental methods
2.1 Experimental groups and dosing regimens
2.1.1 basis for dose selection
Clinical dosage: the children's stomachic oral liquid is 10ml (containing 16g crude drug) once, 3 times a day;
the high dose and the low dose of the rat are respectively increased and decreased by 2 times by taking 50g crude drug/kg as a medium dose;
2.1.2 grouping
After the adaptation period, 110 rats with good health condition are selected and divided into 11 groups according to a random digital table method, wherein each group comprises 10 rats, and the rats are respectively a blank control group, a model control group, a positive control group, a comparative example 1-3 group and an example 1-3 group;
2.1.3 preparation of medicinal liquid
The traditional Chinese medicine composition in each embodiment of the invention comprises the following components: the composition of example 3 was administered by gavage at 1mL/100g, wherein the composition was administered in three dose groups of 100g crude drug/kg (large dose), 50g crude drug/kg (medium dose) and 25g crude drug/kg (small dose) at 0.5% CMC-Na, and the remaining examples were administered in the medium dose group, stored at 4 ℃ and mixed before use every day;
oral liquid for invigorating stomach of children: taking an appropriate amount of the extract for invigorating stomach of children, preparing with 0.5% CMC-Na, preserving at 4 deg.C, and mixing well before use every day;
2.2 Molding
Except the blank control group, the other groups adopt a method of chronic restraint stress, excessive fatigue and diet loss to mold, namely an FD model; placing the model-making rat in a binding box to bind for 3h every morning, swimming for 10min in the afternoon, fasting every other day, feeding enough food every other day, and clamping tail to irritate the rat every other day for 30min for 3 weeks; observing general conditions of animals every day, including hair color, mental state, emotional response, defecation and urination 1 time, and measuring the food intake and body weight of the animals 1 time per week;
2.3 preparation of a nutritional semisolid paste
Mixing 16g of milk powder, 10g of sodium carboxymethylcellulose, 8g of sugar, 8g of starch, 6g of activated carbon and 300ml of sterilized water for injection, and uniformly stirring to prepare black semisolid paste;
2.4 gastric emptying Rate, intestinal Pushing Rate
Selecting 110 experimental animals on day 8, dividing into 11 groups according to weight and food intake, each group containing 10 animals, respectively administering solvent control, positive control drug or test substance according to group, 1 time per day, and continuously adding into the group14 days; overnight fasting is performed on night at day 21, solvent control, positive control drug or test substance is respectively administered to all animals on day 22, carbon powder-containing nutritional paste is administered after 1.5h, and excessive CO is inhaled after 30min 2 Performing deep anesthesia and sacrifice, opening the abdominal cavity, ligating the cardia and the pylorus, picking up stomach tissue, weighing the full weight (S1) and the net weight (S2) of the stomach, and calculating the gastric emptying rate; surgically removing the tissues of the small intestine from the pylorus to the caecum, measuring the total length (L1) and the carbon dust advancing length (L2), photographing, and calculating the advancing rate of the small intestine;
the calculation formula of the gastric emptying rate and the small intestine propulsion rate is as follows:
gastric emptying rate = (mass of 1- (S1-S2)/nutritious semisolid paste) × 100%
Small intestine propulsion = carbon-tip propulsion length/total length × 100%
2.5 gastric secretion measurement
Taking out the content in the stomach, centrifuging the content and recording the total amount of gastric juice; taking 1mL of centrifuged supernatant, adding 1 drop of phenol red indicator, carrying out neutralization titration by using 20mmol/L NaOH, recording the consumed NaOH solution amount, and finally calculating the total acidity and the total acid discharge amount;
the total acidity and total acid output are calculated as follows:
total acidity (mmol/L) = NaOH volume used for titration x 2%
Total acid output (mmol/L) = total acidity x amount of gastric acid per hour
2.6 statistics of data
Statistical analysis is carried out on experimental data by adopting SPSS22.0 software, the measured data is represented by Mean value plus or minus standard deviation (Mean plus or minus SD), the difference between groups is analyzed by adopting one-factor variance, and the difference p is less than 0.05 and is significance difference;
3. results of the experiment
TABLE 1 Effect on gastric emptying Rate, small intestine Propulsion Rate
* Comparison with model group: p is less than 0.05; * Comparison with model group: p is less than 0.01;
■ Compared with the children's stomachic oral liquid group: p is less than 0.05; ■ 9632comparing with children's oral liquid: p is less than 0.01;
# comparison with comparative example 1: p is less than 0.05; # compared to comparative example 1: p is less than 0.01;
comparison with comparative example 2: p <0.05, O > compared with comparative example 2: p is less than 0.01;
● Comparison with comparative example 3: p <0.05, \9679; \9679forcomparison with comparative example 3: p is less than 0.01;
TABLE 2 Effect on gastric secretion amount
* Comparison with model group: p is less than 0.05; * Comparison with model group: p is less than 0.01;
■ Compared with the children's stomachic oral liquid group: p is less than 0.05; ■ 9632comparing with children's oral liquid: p is less than 0.01;
# comparison with comparative example 1: p is less than 0.05; # compared to comparative example 1: p is less than 0.01;
comparison with comparative example 2: p <0.05, O > compared to comparative example 2: p is less than 0.01;
● Comparison with comparative example 3: p <0.05, \9679, comparison with comparative example 3: p is less than 0.01.
2. Physiological Activity test in rats
The purpose is as follows: observing the influence of the traditional Chinese medicine composition on the rat body quality, abdominal circumference, food intake and defecation amount;
1 materials and drugs
1.1 Experimental animals:
previously feeding for three days to adapt to the environment;
1.2 Experimental drugs:
the tested drugs are: the Chinese medicinal composition (source: jilin Huakang pharmaceutical industry Co., ltd.) in each example of the invention;
positive drugs: oral liquid for invigorating stomach of children (source: jilin Huakang pharmaceutical industry GmbH, inc.; national Standard B20020507; specification: 10 ml/count);
blank control: sterilizing water for injection;
1.3, preparing the medicine:
the traditional Chinese medicine composition in each embodiment of the invention comprises the following components: the composition of example 3 was administered by gavage at 1mL/100g, wherein the composition was administered in three dose groups of 100g crude drug/kg (large dose), 50g crude drug/kg (medium dose) and 25g crude drug/kg (small dose) at 0.5% CMC-Na, and the remaining examples were administered in the medium dose group, stored at 4 ℃ and mixed before use every day;
oral liquid for invigorating stomach of children: taking an appropriate amount of the extract for invigorating stomach of children, preparing with 0.5% of CMC-Na, preserving at 4 deg.C, and mixing well before use every day;
2 modeling, grouping and administering
2.1, molding: feeding common feed to the blank group, feeding self-made high-protein and high-heat feed (biscuit made by mixing dried meat floss, bean flour, flour and milk powder) to the model group rat, and freely drinking water for 7 days continuously; recording the body mass and abdominal circumference of each group of rats and the average food intake and excrement amount of each rat in the current day after the model building is successful;
2.2 grouping: after the model building is successful, the rats are randomly divided into a model group, a positive drug control group, an example 1-3 group and a comparative example 1-3 group, wherein each group comprises 10 rats; taking another 10 rats in the blank group as a blank control group;
2.3 administration: the blank control group was fed with normal feed, and the remaining rats were fed with high protein, high calorie feed;
the preparation is administrated by gastric administration according to 1mL/100g, three dose groups of a positive drug control group and the preparation of the invention are respectively infused with corresponding liquid medicines, a blank control group and a model group are administrated with distilled water with the same volume once a day for 7 days, and the body mass and abdominal circumference of each group of rats and the average food intake and defecation amount of each rat in the day are recorded before the last administration;
3. results of the experiment
TABLE 3 influence on rat body quality, abdominal circumference, appetite and stool volume
* Comparison with model group: p is less than 0.05; * Comparison with model groups: p is less than 0.01;
■ Compared with the children's stomachic oral liquid group: p is less than 0.05; ■ 9632comparing with children's oral liquid: p is less than 0.01;
# comparison with comparative example 1: p is less than 0.05; # compared to comparative example 1: p is less than 0.01;
comparison with comparative example 2: p <0.05, O > compared with comparative example 2: p is less than 0.01;
● Comparison with comparative example 3: p <0.05, \9679, comparison with comparative example 3: p is less than 0.01.
Finally, it should be noted that the above-mentioned contents are only used for illustrating the technical solutions of the present invention, and not for limiting the protection scope of the present invention, and that the simple modifications or equivalent substitutions of the technical solutions of the present invention by those of ordinary skill in the art can be made without departing from the spirit and scope of the technical solutions of the present invention.
Claims (10)
1. A traditional Chinese medicine composition for infantile indigestion with food retention is characterized in that: the raw materials consist of the following components: eugenol, fructus Hordei Germinatus, mume fructus, fructus oryzae Germinatus, dioscin, allantoin, quercetin, hyperoside, oligomeric procyanidin, hesperidin, nobiletin, and hesperetin.
2. The traditional Chinese medicine composition according to claim 1, wherein: the raw materials comprise the following components in parts by weight: 60-68 parts of eugenol, 8800-9100 parts of malt, 5300-5500 parts of smoked plum, 8800-9100 parts of rice sprout, 0.2-0.8 part of dioscin, 22-24.5 parts of allantoin, 0.2-0.6 part of quercetin, 1.2-1.5 parts of hyperoside, 100-118 parts of oligomeric proanthocyanidin, 36-40 parts of hesperidin, 9-9.8 parts of nobiletin and 5.5-5.8 parts of hesperetin.
3. The traditional Chinese medicine composition according to claim 1, characterized in that: the raw materials comprise the following components in parts by weight: 66 parts of eugenol, 9000 parts of malt, 5400 parts of dark plum fruit, 9000 parts of rice sprout, 0.55 part of dioscin, 22.5 parts of allantoin, 0.54 part of quercetin, 1.35 parts of hyperin, 108 parts of oligomeric proanthocyanidin, 37.5 parts of hesperidin, 9.37 parts of nobiletin and 5.62 parts of hesperetin.
4. The traditional Chinese medicine composition according to claim 1, characterized in that: the weight ratio of the allantoin to the nobiletin is 22-24.5.
5. The traditional Chinese medicine composition according to claim 1, characterized in that: the weight ratio of the allantoin to the nobiletin is 22.5.
6. The method for preparing a Chinese medicinal composition according to any one of claims 1 to 5, which comprises the following steps: the method comprises the following steps:
(1) Mixing fructus Hordei Germinatus, mume fructus, and fructus oryzae Germinatus, adding water, extracting, and concentrating to obtain fluid extract;
(2) Adding eugenol, dioscin, allantoin, quercetin, hyperoside, oligomeric procyanidin, hesperidin, nobiletin, and hesperetin into the fluid extract, and mixing.
7. The method of claim 6, wherein: the water-adding extraction in the step (1) specifically comprises the following steps: adding 8-10 times of water, decocting for 1-2 hr, filtering to obtain extractive solution A and residue, adding 5-6 times of water, decocting for 2 hr, filtering to obtain extractive solution B, and mixing extractive solutions A and B.
8. Use of the Chinese medicinal composition of any one of claims 1-5 in the preparation of a medicament for infantile indigestion with food retention.
9. A medicine for treating infantile indigestion with food retention is characterized in that: comprises the traditional Chinese medicine composition of any one of claims 1 to 5 and medically usable auxiliary materials.
10. The medicament of claim 9, wherein: the dosage form of the medicine comprises tablets, capsules, granules, paste, liquid, pills or suspension.
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