CN111297974A - Application of traditional Chinese medicine composition in preparation of medicine for treating food stagnation - Google Patents
Application of traditional Chinese medicine composition in preparation of medicine for treating food stagnation Download PDFInfo
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Abstract
The invention belongs to the technical field of traditional Chinese medicines, and particularly relates to application of a traditional Chinese medicine composition in preparation of a medicine for treating food stagnation. The traditional Chinese medicine composition has the effects of promoting digestion, removing food stagnation, invigorating stomach and tonifying spleen, and can effectively treat food stagnation, and clinical tests prove that the effective rate of the traditional Chinese medicine composition for treating food stagnation is more than 95%.
Description
Technical Field
The invention relates to a new application of a traditional Chinese medicine composition, in particular to an application of a traditional Chinese medicine composition in preparing a medicine for treating food stagnation, and belongs to the technical field of traditional Chinese medicines.
Background
Food stagnation, abbreviated as food stagnation, is one of nine kinds of food stagnation, which means food stagnation can not be digested and becomes accumulated for a long time. The disease is mostly seen in people with improper diet, spleen and stomach damage and spleen and stomach weakness, and is mainly caused by overeating, diet stagnation, weakness in transportation, fat, sweet, thick and greasy or spicy food, dampness and heat generated in brewing, gastrointestinal or sexual intercourse, uncooked food, cold dampness, internal retention of cold and dampness and middle yang damage; the pathogenesis of disorder of food reception and transformation, food stagnation, dysfunction of transportation and transformation, disharmony between the stomach and the intestine and stomach-qi deficiency. The clinical manifestations are abdominal fullness and distention, pain and tenderness, eructation and acid regurgitation, anorexia and nausea, pain and desire to purge, pain reduction after purging, constipation, thick and greasy tongue coating, slippery pulse, and severe cases may cause functional dyspepsia, functional constipation, etc.
Food stagnation can be relieved by stopping eating once or twice, and the patients can be cured by taking the treatment prescription for a long time. At present, the treatment of the food stagnation syndrome is mainly based on the traditional Chinese medicine treatment, the western medicine treatment can only temporarily treat actual symptoms, and the recurrence rate of the symptoms is high after the medicine is stopped, for example, the microecological preparation can promote the normal flora colonization of the intestinal tract of children suffering from food stagnation and recover the gastrointestinal function, but can only temporarily solve the symptoms, and the symptoms recur for a long time after the medicine is stopped. The traditional Chinese medicine is mainly used for treating the syndrome of food stagnation by adopting a digestion-promoting and stomach-harmonizing method, but the digestion-promoting and stagnation-removing medicines are mostly cold and cool traditional Chinese medicines and often hurt the spleen and stomach, so that the traditional Chinese medicine is used for treating diseases in clinical application and cannot remove the stagnation of the spleen and stomach, and some stomach-harmonizing medicines are added while the digestion-promoting and stagnation-removing medicines are used for constantly protecting the spleen and stomach to eliminate pathogenic factors without damaging the body resistance.
Chinese invention patent CN100453105C discloses a composition with functions of relaxing bowels, expelling toxin, losing weight and reducing fat and a preparation method thereof, and the product 'Hui Tong jiao Nang' prepared by the Chinese patent is approved to be on the market and can effectively treat functional constipation clinically.
In the Chinese patent medicine products on the market at present, fewer medicines for treating food stagnation are available, most medicines are used for treating the food stagnation when gastrointestinal diseases are treated, and for patients with the food stagnation, the medicines are low in selectivity and inconvenient to take.
Disclosure of Invention
In order to solve the technical problems, the invention discloses application of a traditional Chinese medicine composition in preparing a medicine for treating food stagnation. It is to be noted that the application of the Chinese medicinal composition is a new application developed on the basis of the Chinese patent of invention CN 100453105C.
The Chinese medicinal composition is mainly prepared from fructus Aurantii Immaturus, Atractylodis rhizoma, Ginseng radix, fructus Lycii, colla Corii Asini, and optionally Polygoni Multiflori radix, semen Cassiae, and Aloe.
The traditional Chinese medicine composition comprises immature bitter orange, bighead atractylodes rhizome, ginseng, medlar, donkey-hide gelatin, polygonum multiflorum, cassia seed and aloe in parts by weight:
50-200 parts of immature bitter orange, 20-100 parts of largehead atractylodes rhizome and 20-100 parts of ginseng
30-150 donkey-hide gelatin of medlar, 30-150 fleece-flower root, 25-400
30-500 parts of cassia seed, 30-600 parts of aloe;
preferably, the traditional Chinese medicine composition comprises immature bitter orange, bighead atractylodes rhizome, ginseng, wolfberry fruit, donkey-hide gelatin, polygonum multiflorum, cassia seed and aloe in parts by weight:
immature bitter orange 80-150, bighead atractylodes rhizome 20-80, ginseng 20-80
30-100 donkey-hide gelatin of medlar, 30-100 fleece-flower root, 60-150
80-180 parts of cassia seed, 100 parts of aloe and 200 parts of aloe;
preferably, the traditional Chinese medicine composition comprises immature bitter orange, bighead atractylodes rhizome, ginseng, wolfberry fruit, donkey-hide gelatin, polygonum multiflorum, cassia seed and aloe in parts by weight:
80-120 parts of immature bitter orange, 30-50 parts of bighead atractylodes rhizome and 20-50 parts of ginseng
50-80 donkey-hide gelatin of medlar, 40-80 fleece-flower root, 80-120
100 cassia seeds, 150 aloe, 120 aloe, 160;
preferably, the traditional Chinese medicine composition comprises immature bitter orange, bighead atractylodes rhizome, ginseng, wolfberry fruit, donkey-hide gelatin, polygonum multiflorum, cassia seed and aloe in parts by weight:
immature bitter orange 90 bighead atractylodes rhizome 50 ginseng 40
Wolfberry fruit 60 donkey-hide gelatin 50 fleece-flower root 80
Cassia seed 100 aloe 120
The traditional Chinese medicine composition comprises the following components:
the immature bitter orange enters spleen and stomach channels, breaks qi and removes food retention, eliminates phlegm and disperses abdominal mass, specially controls qi descending, is good at breaking stagnant qi, removing food retention and removing abdominal mass and is used for treating diseases of stagnant qi stagnation and qi obstruction with abdominal mass and distending pain and food retention and abdominal mass retention, or diseases of warm air and intestine and stomach damp-heat retention; bighead atractylodes rhizome, rhizoma Atractylodis Macrocephalae, as the essential herb for invigorating spleen, has the actions of invigorating spleen and stomach, tonifying qi, drying dampness and inducing diuresis. The combination of the two medicines has the effects of strengthening the spleen, activating qi, tonifying and eliminating, and eliminating both the effects of tonifying and eliminating, is used for treating abdominal distension and fullness and indigestion accumulation, and is a monarch medicine in the formula.
According to the traditional Chinese medicine, the liver depression is not comfortable, and the qi of the middle-jiao is not smooth, so that the food is stagnated due to the qi depression; qi stagnation may cause disorder of the spleen and stomach and food stagnation. The medlar and the donkey-hide gelatin both enter liver and kidney channels, nourish liver and kidney, enrich blood, nourish yin, moisten dryness, tonify liver and also tonify spleen, and are ministerial drugs in the formula.
Polygoni Multiflori radix enters liver, heart and kidney meridians; semen Cassiae enters liver and large intestine meridians; aloe enters liver, stomach and large intestine meridians, and has the actions of clearing heat, purging fire, moistening intestine and purging stomach, so it is used as adjuvant drug in the recipe for both syndrome of damp-heat accumulation in stomach and intestine.
Ginseng radix enters spleen, lung, heart and kidney meridians. It is a guiding drug in the recipe to tonify primordial qi, tonify spleen and lung, promote fluid production and nourish blood, and to harmonize the effects of the drugs.
In the traditional Chinese medicine formula, the monarch, minister, assistant and guide medicines are scientific in compatibility, digestion is promoted, stagnation is removed, spleen and qi are strengthened and qi are benefited, spleen and stomach are strengthened, and the traditional Chinese medicine has a remarkable curative effect on food stagnation clinically.
The traditional Chinese medicine composition can be prepared into oral pharmaceutical preparations, and the oral preparations are pills, granules, capsules, tablets or oral liquid; preferably, the oral formulation is a capsule.
The preparation method of the traditional Chinese medicine composition comprises the following steps:
(1) taking the donkey-hide gelatin with the prescription amount, grinding into fine powder, and sieving with a 80-mesh sieve or melting into a donkey-hide gelatin solution for later use;
(2) mixing the ginseng, the tuber fleeceflower root, the cassia seed and the aloe according to the prescription amount, adding 40-80% (volume fraction) of ethanol, extracting for 1-3 times by reflux by an alcohol extraction method, extracting for 1-3 hours each time, filtering the extracting solution, recovering the ethanol, and concentrating to obtain an extract for later use;
(3) mixing fructus Lycii, Atractylodis rhizoma and fructus Aurantii Immaturus according to prescription amount, adding 5-10 times of water, soaking for 0.5-3 hr, decocting for 1-3 hr, and separating the decoction; adding 5-10 times of water into the residue, decocting for 1-3 hr, and separating the decoction; mixing decoctions, and filtering to obtain filtrate;
(4) concentrating the filtrate obtained in the step (3) under reduced pressure until the ratio of the medicinal materials to water is 1-3: 1, adjusting the alcohol to 40-85% (volume fraction), performing cold precipitation for 12-48 hours, filtering, and concentrating the filtrate into an extract for later use;
(5) and (3) mixing or drying the extract obtained in the step (2) and the extract obtained in the step (4), adding the donkey-hide gelatin fine powder or the melted donkey-hide gelatin solution prepared in the step (1), and uniformly mixing to obtain the traditional Chinese medicine composition.
Compared with the prior art, the invention has the following unexpected technical effects:
1) the traditional Chinese medicine composition is an effective prescription for treating food stagnation, and animal experiments show that the traditional Chinese medicine composition can remarkably accelerate the gastric emptying and small intestine propelling speeds of mice; the abdominal circumference of the treated rat is reduced, the food intake is increased, the stool volume is increased, and the physiological activity is obviously improved.
2) Clinical tests show that the traditional Chinese medicine composition can effectively treat food stagnation caused by improper diet and weakness of spleen and stomach of patients, and the total effective rate is 100%.
3) The traditional Chinese medicine composition has the advantages of promoting digestion and removing food stagnation, strengthening spleen and replenishing qi, and tonifying spleen and harmonizing stomach, has comprehensive effects and high treatment effective rate, and has wide market prospect.
DETAILED DESCRIPTION OF EMBODIMENT (S) OF INVENTION
The following experiments are provided to illustrate that the traditional Chinese medicine composition of the invention has the efficacy of treating food stagnation, it should be noted that the medicines used in the following experiments are the preferred embodiments of the invention, and other prescription medicines of the invention can achieve similar experimental effects.
First, pharmacodynamic test of the preparation of the invention
Experimental example 1 gastric emptying test in mice
The purpose is as follows: the effect of the traditional Chinese medicine composition on the gastric emptying speed of mice is observed.
1 materials and drugs
1.1 Experimental animals:
the method comprises the following steps that male SPF-level mice weigh 18-22 g, the weight is provided by a food and drug inspection and detection center in Jining City, and the license number of experimental animals is as follows: SYXK (Lu) 20170006, previously raised for three days to acclimate.
1.2 Experimental drugs:
1) the traditional Chinese medicine composition obtained in embodiment 5 of the invention.
2) Mosapride citrate tablets (5 mg/tablet) trade name: kuaili, Lunanfibrate pharmaceuticals, Inc., manufactured under batch number 20170802.
1.3, preparing the medicine:
1) the traditional Chinese medicine composition in example 5 is prepared into three dose groups of 5.38g crude drugs/kg (large dose), 1.79g crude drugs/kg (medium dose) and 0.60g crude drugs/kg (small dose) according to the gastric lavage administration of 10 mL/kg;
2) the drug is administrated by gastric lavage with 10mL/kg, and is prepared into 1.95mg/kg as a positive drug control group.
2, modeling, grouping and administration:
2.1, molding: the blank group of mice was fed with normal feed, the model group of mice was fed with self-made high protein and high heat feed (the feed is biscuits made by mixing dried meat floss, bean flour, flour and milk powder), and each group of mice had free drinking water for 7 days continuously.
2.2 grouping: taking 50 mice after successful model building, randomly dividing the mice into a model group, a positive drug control group (namely a fast-acting group) and three dose groups of the invention, wherein the total number of the three dose groups is 5, and each group contains 10 mice; another blank group of 10 mice was used as a blank control group.
2.3 administration: the placebo group was still fed with normal feed and the remaining mice were still fed with high protein, high calorie feed.
The medicine is administrated by intragastric administration according to 0.1mL/10g, corresponding liquid medicines are respectively infused into a positive medicine control group and three dose groups of the invention, and distilled water with the same volume is administrated into a blank control group and a model group. The mice in each group were fasted once a day for 7 days 18h before the last dose without water deprivation.
3 results of the experiment
3.1 examination index last administration or filling with distilled water for 1h, gavage administration to each group of mice 0.1% methyl orange solution 0.2mL, 20min later, cervical spine removal to sacrifice mice, laparotomy to take off stomach, fully washing gastric contents in a small beaker with distilled water, pouring into a centrifuge tube, centrifuging at 3000r/min for 5min, taking supernatant, adding distilled water to 10mL, using UV-3100 UV visible spectrophotometer to color comparison at 420nm wavelength, measuring absorbance, and taking optical density of methyl orange in stomach. And adding 0.2mL of 0.1% methyl orange solution into 10mL of distilled water, shaking uniformly, measuring the absorbance, taking the absorbance as the base number of methyl orange, and calculating the residual rate.
3.2 results of the experiment
The preparation (0.60g, 1.79g and 5.38g crude drug/kg dose) of the invention has significant promotion effect on gastric emptying of mice with dyspepsia, and compared with a model group, the preparation has significant difference or very significant difference (*P＜0.05，#P＜0.01)。
TABLE 1 Effect of the formulations of the invention on gastric emptying propulsion in mice
Note: in comparison with the set of models,*P＜0.05，#P＜0.01。
experimental example 2 mouse intestinal Propulsion test
The purpose is as follows: the influence of the traditional Chinese medicine composition on the small intestine propulsion speed of the mice with spleen deficiency and stagnation is observed.
1 materials and drugs
1.1 Experimental animals:
the method comprises the following steps that male SPF-level mice weigh 18-22 g, the weight is provided by a food and drug inspection and detection center in Jining City, and the license number of experimental animals is as follows: SYXK (Lu) 20170006, previously raised for three days to acclimate.
1.2 Experimental drugs:
1) the traditional Chinese medicine composition obtained in embodiment 5 of the invention.
2) Mosapride citrate tablets (5 mg/tablet) trade name: kuaili, Lunanfibrate pharmaceuticals, Inc., manufactured under batch number 20170802.
1.3, preparing the medicine:
1) the traditional Chinese medicine composition in example 5 is prepared into three dose groups of 5.38g crude drugs/kg (large dose), 1.79g crude drugs/kg (medium dose) and 0.60g crude drugs/kg (small dose) according to the gastric lavage administration of 10 mL/kg;
2) the drug is administrated by gastric lavage with 10mL/kg, and is prepared into 1.95mg/kg as a positive drug control group.
2, modeling, grouping and administration:
2.1, molding: feeding a blank group of mice with common feeding, feeding a model group of mice with self-made high-protein and high-heat feed (the feed is biscuits made by mixing dried meat floss, bean flour, flour and milk powder), and simultaneously feeding ice milk with 1ml/10g, wherein each group of mice can drink water for 7 days continuously.
2.2 grouping: taking 50 mice after successful model building, randomly dividing the mice into a model group, a positive drug control group (namely a fast-acting group) and three dose groups of the invention, wherein the total number of the three dose groups is 5, and each group contains 10 mice; another blank group of 10 mice was used as a blank control group.
2.3 administration: the placebo group was still fed with normal feed and the remaining mice were still fed with high protein, high calorie feed.
The medicine is administrated by gastric perfusion according to 10mL/kg, corresponding liquid medicines are respectively infused into a positive control (fast acting) group and three dose groups of the medicine, and distilled water with the same volume is administrated into a blank control group and a model group. The mice in each group were fasted once a day for 7 days 18h before the last dose without water deprivation.
3 results of the experiment
3.1 detection indexes after the last administration or the filling of distilled water for 1h, the mice of each group are subjected to intragastric administration and administration of 0.2mL/10g of freshly prepared 5% carbon powder suspension, the cervical vertebrae are removed after 10min to kill the mice, the small intestines are quickly taken out, mesentery is gently stripped and laid flat, the distance between the total length of the small intestines (taking the pylorus of the stomach as a starting point and the ileocecal part as an end point) and the distance between the carbon powder suspension and the end of the small intestines from the pyloric sphincter is measured, and the small intestine propulsion rate is calculated.
3.2 results of the experiment
The preparation (0.60g, 1.79g and 5.38g crude drugs/kg) of the invention has significant promotion effect on the small intestine propulsion of the mice with dyspepsia, and has significant difference or very significant difference compared with a model group ((*P＜0.05，#P＜0.01)。
TABLE 2 thisEffect of the inventive formulations on gastric emptying propulsion in mice
Note: in comparison with the set of models,*P＜0.05，#P＜0.01。
experimental example 3 physiological Activity test in rats
The purpose is as follows: the influence of the traditional Chinese medicine composition on the body quality, abdominal circumference, food intake and defecation amount of the rat is observed.
1 materials and drugs
1.1 Experimental animals:
the weight of a male SD rat is 180-220 g, the weight is provided by a food and drug inspection and detection center in Jining City, and the license number of an experimental animal is as follows: SYXK (Lu) 20170006, previously raised for three days to acclimate.
1.2 Experimental drugs:
1) the traditional Chinese medicine composition obtained in embodiment 5 of the invention.
2) Mosapride citrate tablets (5 mg/tablet) trade name: kuaili, Lunanfibrate pharmaceuticals, Inc., manufactured under batch number 20170502.
1.3, preparing the medicine:
1) the traditional Chinese medicine composition in example 5 is prepared into three dose groups of 5.38g crude drugs/kg (large dose), 1.79g crude drugs/kg (medium dose) and 0.60g crude drugs/kg (small dose) according to the gastric lavage administration of 10 mL/kg;
2) the drug is administrated by gastric lavage with 10mL/kg, and is prepared into 1.34mg/kg as a positive drug control group.
2 modeling, grouping and administering
2.1, molding: the blank group is fed with common feed, the model group rat is fed with self-made high-protein and high-heat feed (the feed is biscuits made by mixing dried meat floss, bean flour, flour and milk powder), and each group drinks water freely for 7 days continuously. After the model building is successful, the body mass, abdominal circumference, average food intake and excrement amount of each rat in the current day are recorded.
2.2 grouping: after the model building is successful, the rats are randomly divided into a model group, a positive drug control group (namely a fast acting group) and three dose groups, wherein the number of the dose groups is 5, and each group contains 10 rats; another blank group of 10 rats was used as a blank control group.
2.3 administration: the placebo group was still fed with normal feed and the remaining rats were still fed with high protein, high calorie feed.
The medicine is administrated by gastric perfusion according to 10mL/kg, three dose groups of a positive medicine control group and the preparation of the invention are respectively infused with corresponding liquid medicine, a blank control group and a model group are administrated with distilled water with the same volume once a day for 7 days, and the body mass, the abdominal circumference and the average food intake and the excrement amount of each rat on the day are recorded before the last administration.
3 results of the experiment
The preparation of the invention (three doses of 0.60g, 1.79g and 5.38g crude drugs/kg) has good regulating effect on the physiological activities of rats with food retention, can obviously increase the food intake, relieve the abdominal distension symptom and improve the defecation amount, has significant difference or extremely significant difference (P is less than 0.05,#P＜0.01)。
TABLE 3 Effect of the formulations of the invention on the physiological Activity of rats
Note: 1.2, 3 respectively representing the test conditions before molding, after molding and after medicine application;
compared with the model natural recovery group,*P＜0.05，#P＜0.01。
secondly, the preparation of the invention has typical cases of food stagnation
1 case of disease
Through diagnosis, 15 patients with the confirmed disease condition of food stagnation are aged 50-70 years, and the disease condition has no significant difference (P is more than 0.05).
2 diagnostic criteria
The clinical manifestations of abdominal distention, belching, sour and rancidness, nausea and vomiting, uncomfortable defecation, thick and greasy tongue coating and slippery pulse are that no organic diseases are seen through physical examination, blood biochemistry and digestive tract endoscopy.
3 therapeutic agents
The capsule obtained in example 5 of the present invention.
4 standard of therapeutic effect
The effect is shown: the symptoms disappear, and the normal state is checked;
improvement: the symptoms and signs are obviously relieved;
and (4) invalidation: no obvious change in symptoms and signs.
5 results of the test
After 2 days of treatment, the therapeutic effect is shown in table 4.
TABLE 4 therapeutic Effect of the treatment group and the observation group
| Show effect | Improvement of life | Invalidation | Total effective rate (%) |
| 14 | 1 | 0 | 100 |
The effective rate of the patient after treatment reaches 100%, the patient has no clinical symptoms, the condition of the patient with serious stagnation is obviously improved, and the patient does not relapse in a short period after the treatment.
The results prove that the traditional Chinese medicine composition can effectively treat food stagnation clinically and improve clinical symptoms of patients, the illness state of the patients does not relapse within a short time, and the medication compliance of the patients is good.
Third, detailed description of the invention
The following examples are preferred embodiments of the present invention and do not limit the scope of the invention as claimed.
Example 1
The prescription is as follows:
immature bitter orange 200 parts by weight, bighead atractylodes rhizome 20 parts by weight, ginseng 100 parts by weight
30 parts of medlar, 150 parts of donkey-hide gelatin, 25 parts of fleece-flower root
500 parts by weight of cassia seed and 30 parts by weight of aloe.
The preparation method of the traditional Chinese medicine composition comprises the following steps:
(1) melting the prescription amount of the donkey-hide gelatin into a donkey-hide gelatin solution for later use;
(2) mixing Ginseng radix, Polygoni Multiflori radix, semen Cassiae and Aloe, extracting with ethanol under reflux for 3 times (1 hr each time) and 40% (volume fraction) ethanol, filtering extractive solution, recovering ethanol, and concentrating to obtain extract;
(3) mixing fructus Lycii, Atractylodis rhizoma and fructus Aurantii Immaturus according to prescription amount, adding 10 times (by weight) of water, soaking for 0.5 hr, decocting for 2 hr, and separating the decoction; adding 5 times (by mass) of water into the medicine residues, decocting for 1 hour, and separating the decoction; mixing decoctions, and filtering to obtain filtrate;
(4) concentrating the filtrate obtained in the step (3) under reduced pressure until the ratio of the medicinal materials to water is 3: 1, adjusting the alcohol to 40% (volume fraction), performing cold precipitation for 48 hours, filtering, and concentrating the filtrate into an extract for later use;
(5) and (3) mixing the extract obtained in the step (2) and the extract obtained in the step (4), adding the melted donkey-hide gelatin solution obtained in the step (1), and uniformly mixing to obtain the traditional Chinese medicine composition.
Making into tablet by conventional method.
Example 2
The prescription is as follows:
50 parts of immature bitter orange, 100 parts of largehead atractylodes rhizome and 20 parts of ginseng
150 parts of medlar, 30 parts of donkey-hide gelatin, 400 parts of fleece-flower root
30 parts of cassia seed, 600 parts of aloe.
The preparation method of the traditional Chinese medicine composition comprises the following steps:
(1) grinding colla Corii Asini into fine powder, sieving with 80 mesh sieve;
(2) mixing Ginseng radix, Polygoni Multiflori radix, semen Cassiae and Aloe, extracting with ethanol under reflux for 3 hr for 1 time and 80% (volume fraction) ethanol, filtering the extractive solution, recovering ethanol, and concentrating to obtain extract;
(3) mixing wolfberry fruit, bighead atractylodes rhizome and immature bitter orange according to the prescription amount, adding 5 times (by mass) of water, soaking for 3 hours, decocting for 1 hour, and separating the decoction; adding 5 times (by mass) of water into the medicine residues, decocting for 1 hour, and separating the decoction; mixing decoctions, and filtering to obtain filtrate;
(4) concentrating the filtrate obtained in the step (3) under reduced pressure until the ratio of the medicinal materials to water is 3: 1, adjusting the alcohol to 85% (volume fraction), performing cold precipitation for 12 hours, filtering, and concentrating the filtrate into an extract for later use;
(5) and (3) drying the extract obtained in the step (2) and the extract obtained in the step (4), adding the sieved donkey-hide gelatin fine powder prepared in the step (1), and uniformly mixing to obtain the traditional Chinese medicine composition.
Making into syrup according to conventional syrup preparation method.
Example 3
The prescription is as follows:
immature bitter orange 150 parts by weight of bighead atractylodes rhizome 20 parts by weight of ginseng 20 parts by weight
100 parts of medlar, 30 parts of donkey-hide gelatin, 150 parts of fleece-flower root
80 parts of cassia seed, 200 parts of aloe.
The preparation method of the traditional Chinese medicine composition comprises the following steps:
(1) melting the prescription amount of the donkey-hide gelatin into a donkey-hide gelatin solution for later use;
(2) mixing the ginseng, the tuber fleeceflower root, the cassia seed and the aloe according to the prescription amount, adding 40-80% (volume fraction) of ethanol, extracting for 1-3 times by reflux by an alcohol extraction method, extracting for 1-3 hours each time, filtering the extracting solution, recovering the ethanol, and concentrating to obtain an extract for later use;
(3) mixing fructus Lycii, Atractylodis rhizoma and fructus Aurantii Immaturus according to prescription amount, adding 5-10 times (by mass) of water, soaking for 0.5-3 hr, decocting for 1-3 hr, and separating decoction; adding 5-10 times (by mass) of water into the residue, decocting for 1-3 hr, and separating the decoction; mixing decoctions, and filtering to obtain filtrate;
(4) concentrating the filtrate obtained in the step (3) under reduced pressure until the ratio of the medicinal materials to water is 2: 1, adjusting the alcohol to 40-85% (volume fraction), performing cold precipitation for 36 hours, filtering, and concentrating the filtrate into an extract for later use;
(5) and (3) mixing or drying the extract obtained in the step (2) and the extract obtained in the step (4), adding the melted donkey-hide gelatin solution prepared in the step (1), and uniformly mixing to obtain the traditional Chinese medicine composition.
Making into granule according to conventional granule preparation process.
Example 4
The prescription is as follows:
80 parts by weight of immature bitter orange, 80 parts by weight of largehead atractylodes rhizome and 80 parts by weight of ginseng
30 parts of medlar, 100 parts of donkey-hide gelatin, 60 parts of tuber fleeceflower root
180 parts of cassia seed and 100 parts of aloe.
The preparation method of the traditional Chinese medicine composition comprises the following steps:
(1) grinding colla Corii Asini into fine powder, sieving with 80 mesh sieve;
(2) mixing Ginseng radix, Polygoni Multiflori radix, semen Cassiae and Aloe, extracting with ethanol under reflux for 3 times (1 hr each time) with 60% (volume fraction) ethanol, filtering extractive solution, recovering ethanol, and concentrating to obtain extract;
(3) mixing wolfberry fruit, bighead atractylodes rhizome and immature bitter orange according to the prescription amount, adding 7 times (by mass) of water, soaking for 1 hour, decocting for 3 hours, and separating the decoction; adding 5 times (by mass) of water into the medicine residues, decocting for 2 hours, and separating decoction; mixing decoctions, and filtering to obtain filtrate;
(4) concentrating the filtrate obtained in the step (3) under reduced pressure until the ratio of the medicinal materials to water is 2: 1, adjusting the alcohol to 50% (volume fraction), performing cold precipitation for 24 hours, filtering, and concentrating the filtrate into an extract for later use;
(5) and (3) drying the extract obtained in the step (2) and the extract obtained in the step (4), adding the sieved donkey-hide gelatin fine powder prepared in the step (1), and uniformly mixing to obtain the traditional Chinese medicine composition.
Making into pill according to conventional pill preparation process.
Example 5
The prescription is as follows:
immature bitter orange 90 parts by weight, bighead atractylodes rhizome 50 parts by weight, ginseng 40 parts by weight
60 parts of medlar, 50 parts of donkey-hide gelatin, 80 parts of fleece-flower root
100 parts by weight of cassia seed and 120 parts by weight of aloe.
The preparation method of the traditional Chinese medicine composition comprises the following steps:
(1) melting the prescription amount of the donkey-hide gelatin into a donkey-hide gelatin solution for later use;
(2) mixing Ginseng radix, Polygoni Multiflori radix, semen Cassiae and Aloe, extracting with 60% (volume fraction) ethanol under reflux for 2 times (2 hr each time), filtering extractive solution, recovering ethanol, and concentrating to obtain extract;
(3) mixing medlar, largehead atractylodes rhizome and immature bitter orange according to the prescription amount, adding 8 times (by mass) of water, soaking for 2 hours, decocting for 2 hours, and separating decoction; adding 5 times (by mass) of water into the medicine residues, decocting for 2 hours, and separating decoction; mixing decoctions, and filtering to obtain filtrate;
(4) concentrating the filtrate obtained in the step (3) under reduced pressure until the ratio of the medicinal materials to water is 2: 1, adjusting the alcohol to 60% (volume fraction), performing cold precipitation for 20 hours, filtering, and concentrating the filtrate into an extract for later use;
(5) and (3) mixing the extract obtained in the step (2) and the extract obtained in the step (4), adding the melted donkey-hide gelatin solution obtained in the step (1), and uniformly mixing to obtain the traditional Chinese medicine composition.
Making into capsule by conventional method.
Example 6
The prescription is as follows:
80 parts of immature bitter orange, 50 parts of largehead atractylodes rhizome and 20 parts of ginseng
80 parts of medlar, 40 parts of donkey-hide gelatin, 120 parts of fleece-flower root
100 parts of cassia seed, 160 parts of aloe.
The preparation method of the traditional Chinese medicine composition comprises the following steps:
(1) grinding colla Corii Asini into fine powder, sieving with 80 mesh sieve;
(2) mixing Ginseng radix, Polygoni Multiflori radix, semen Cassiae and Aloe, extracting with ethanol under reflux for 3 hr for 3 times, filtering extractive solution, recovering ethanol, and concentrating to obtain extract;
(3) mixing fructus Lycii, Atractylodis rhizoma and fructus Aurantii Immaturus according to prescription amount, adding 6 times (by weight) of water, soaking for 0.5 hr, decocting for 3 hr, and separating the decoction; adding 8 times (by mass) of water into the decoction dregs, decocting for 1 hour, and separating the decoction; mixing decoctions, and filtering to obtain filtrate;
(4) concentrating the filtrate obtained in the step (3) under reduced pressure until the ratio of the medicinal materials to water is 1: 1, adjusting the alcohol to 50% (volume fraction), performing cold precipitation for 24 hours, filtering, and concentrating the filtrate into an extract for later use;
(5) and (3) drying the extract obtained in the step (2) and the extract obtained in the step (4), adding the sieved donkey-hide gelatin fine powder prepared in the step (1), and uniformly mixing to obtain the traditional Chinese medicine composition.
Making into capsule by conventional method.
Example 7
The prescription is as follows:
120 parts of immature bitter orange, 30 parts of white atractylodes rhizome and 50 parts of ginseng
50 parts of medlar, 80 parts of donkey-hide gelatin, 80 parts of tuber fleeceflower root
150 parts of cassia seed, 120 parts of aloe.
The preparation method of the traditional Chinese medicine composition comprises the following steps:
(1) grinding colla Corii Asini into fine powder, sieving with 80 mesh sieve;
(2) mixing Ginseng radix, Polygoni Multiflori radix, semen Cassiae and Aloe, extracting with ethanol under reflux for 3 times (1 hr each time) with 60% (volume fraction) ethanol, filtering extractive solution, recovering ethanol, and concentrating to obtain extract;
(3) mixing wolfberry fruit, bighead atractylodes rhizome and immature bitter orange according to the prescription amount, adding 5 times (by mass) of water, soaking for 3 hours, decocting for 2 hours, and separating the decoction; adding 8 times (by mass) of water into the decoction dregs, decocting for 1 hour, and separating the decoction; mixing decoctions, and filtering to obtain filtrate;
(4) concentrating the filtrate obtained in the step (3) under reduced pressure until the ratio of the medicinal materials to water is 2: 1, adjusting the alcohol to 70% (volume fraction), performing cold precipitation for 12 hours, filtering, and concentrating the filtrate into an extract for later use;
(5) and (3) drying the extract obtained in the step (2) and the extract obtained in the step (4), adding the sieved donkey-hide gelatin fine powder prepared in the step (1), and uniformly mixing to obtain the traditional Chinese medicine composition.
Making into oral liquid by conventional method.
Claims (8)
1. A Chinese medicinal composition for treating food stagnation is prepared from fructus Aurantii Immaturus, Atractylodis rhizoma, Ginseng radix, fructus Lycii, and colla Corii Asini.
2. The use of claim 1, wherein the Chinese medicinal composition further comprises polygonum multiflorum, cassia seed and aloe.
3. The use of claim 2, wherein the Chinese medicinal composition comprises immature bitter orange, largehead atractylodes rhizome, ginseng, medlar, donkey-hide gelatin, tuber fleeceflower root, cassia seed and aloe in parts by weight:
50-200 parts of immature bitter orange, 20-100 parts of largehead atractylodes rhizome and 20-100 parts of ginseng
30-150 donkey-hide gelatin of medlar, 30-150 fleece-flower root, 25-400
30-500 parts of cassia seed and 30-600 parts of aloe.
4. The use of claim 3, wherein the Chinese medicinal composition comprises immature bitter orange, largehead atractylodes rhizome, ginseng, medlar, donkey-hide gelatin, tuber fleeceflower root, cassia seed and aloe in parts by weight:
immature bitter orange 80-150, bighead atractylodes rhizome 20-80, ginseng 20-80
30-100 donkey-hide gelatin of medlar, 30-100 fleece-flower root, 60-150
80-180 parts of cassia seed, 100 parts of aloe and 200 parts of aloe.
5. The use of claim 4, wherein the Chinese medicinal composition comprises immature bitter orange, largehead atractylodes rhizome, ginseng, medlar, donkey-hide gelatin, tuber fleeceflower root, cassia seed and aloe in parts by weight:
80-120 parts of immature bitter orange, 30-50 parts of bighead atractylodes rhizome and 20-50 parts of ginseng
50-80 donkey-hide gelatin of medlar, 40-80 fleece-flower root, 80-120
Cassia seed 100-.
6. The use of claim 5, wherein the Chinese medicinal composition comprises immature bitter orange, largehead atractylodes rhizome, ginseng, medlar, donkey-hide gelatin, tuber fleeceflower root, cassia seed and aloe in parts by weight:
immature bitter orange 90 bighead atractylodes rhizome 50 ginseng 40
Wolfberry fruit 60 donkey-hide gelatin 50 fleece-flower root 80
Cassia seed 100 aloe 120.
7. The use according to any one of claims 1 to 6, wherein the traditional Chinese medicine composition is an oral preparation, preferably the oral preparation is a pill, a granule, a capsule, a tablet, a syrup or an oral liquid; further preferably, the oral formulation is a capsule.
8. The use according to any one of claims 1 to 6, wherein the food stagnation is caused by improper diet, damage to the spleen and stomach, and/or weakness of the spleen and stomach.
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN113332373A (en) * | 2021-07-14 | 2021-09-03 | 鲁南制药集团股份有限公司 | Application of aloe cathartic preparation in preparing medicine for treating vomiting |
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| CN1748765A (en) * | 2004-09-17 | 2006-03-22 | 鲁南制药集团股份有限公司 | Composition with catharsis and toxin expelling, fat reducing and weight reducing function and preparing method |
| CN111388587A (en) * | 2018-12-30 | 2020-07-10 | 鲁南制药集团股份有限公司 | Traditional Chinese medicine composition for preparing medicine for treating functional dyspepsia |
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| CN1748765A (en) * | 2004-09-17 | 2006-03-22 | 鲁南制药集团股份有限公司 | Composition with catharsis and toxin expelling, fat reducing and weight reducing function and preparing method |
| CN111388587A (en) * | 2018-12-30 | 2020-07-10 | 鲁南制药集团股份有限公司 | Traditional Chinese medicine composition for preparing medicine for treating functional dyspepsia |
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| CN113332373A (en) * | 2021-07-14 | 2021-09-03 | 鲁南制药集团股份有限公司 | Application of aloe cathartic preparation in preparing medicine for treating vomiting |
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