CN1748765A - Composition with catharsis and toxin expelling, fat reducing and weight reducing function and preparing method - Google Patents
Composition with catharsis and toxin expelling, fat reducing and weight reducing function and preparing method Download PDFInfo
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- CN1748765A CN1748765A CNA200410073958XA CN200410073958A CN1748765A CN 1748765 A CN1748765 A CN 1748765A CN A200410073958X A CNA200410073958X A CN A200410073958XA CN 200410073958 A CN200410073958 A CN 200410073958A CN 1748765 A CN1748765 A CN 1748765A
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Links
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Landscapes
- Medicines Containing Plant Substances (AREA)
Abstract
The Chinese medicine composition with functions of relaxing the bowels, expelling toxin, reducing fat and slimming is prepared with fleeceflower root, cassia seed, aloe, wolfberry fruit, donkey hide gelatin, ginseng and other material, and through different physical and chemical treatment based on the different physical and chemical properties of the components. The Chinese medicine composition is prepared into different clinically acceptable forms, and has unique recipe and obvious treating effect in clinical treatment of constipation.
Description
Technical field
The present invention relates to a kind of Chinese medicine composition with catharsis and toxin expelling, fat reducing and weight reducing function, particularly relating to a kind of is the medicine with catharsis and toxin expelling, fat reducing and weight reducing function that raw material is made with the vegetable Chinese herbal medicine.
Background technology
In the actual life, there is the constipation problem in ten philtrums with regard to a people is arranged.Constipation is said and is not really serious disease, but has a strong impact on people's quality of life, brings many worries to the people.Doctors are divided into constipation the three major types type usually: slow-remove type, outlet obstructed type and mixed type.The medicine of the treatment constipation of using clinically has at present: osmotic laxative, irritant laxative, emollient laxative, permeability caccagogue etc.It is magnesium sulfate that osmotic laxative is mainly represented medicine.But because it can not make colon tension force increase, so should not be used for the slow patient of those intestinal movements.Irritant laxative is because stimulate intestinal mucosa and the intestinal wall plexus nervorum, and may cause the large intestine myasthenia, forms drug dependence, thereby is mainly used in the stool incarceration and needs rapid relieving constipation person, unsuitable prolonged application.The main shortcoming of emollient laxative is that mouthfeel is poor, and a little less than the effect, prolonged application can cause fatsoluble vitamin malabsorption.The major defect of permeability caccagogue is to produce gas at the bacterial action bottom fermentation, causes senses of discomfort such as abdominal distention.
Chinese medicine has accumulated abundant clinical experience in the long periods of treatment practice.But do not have as yet so far and utilize state-of-the-art technology and in conjunction with the modern Chinese medicine of modern preparation process.
Summary of the invention
The purpose of this invention is to provide a kind of Chinese medicine composition with catharsis and toxin expelling, fat reducing and weight reducing function, it can treat constipation quickly and effectively, has reduced stimulation and other physiological damage to intestinal again greatly.
Another object of the present invention provides the preparation method of this Chinese medicine composition.
For achieving the above object, we with reference to modern pharmacological research achievement and former various proved recipes, go the poor essence of getting according to the understanding and the Therapeutic Principle of motherland's medical science to intestinal tract diseases such as constipation, by theory of Chinese medical science, have combined the new side of medicine of the present invention.
The raw material composition of preparation medicine of the present invention comprises as follows by weight:
Radix Polygoni Multiflori 25-400 part Semen Cassiae 30-500 part Aloe 30-600 part.
Fructus Lycii 30-150 part Colla Corii Asini 30-150 part Radix Ginseng 20-100 part
The raw material of preparation medicine of the present invention also contains the component of following weight ratio:
Fructus Aurantii Immaturus 50-200 part Rhizoma Atractylodis Macrocephalae 20-100 part
The raw material preferred weight proportioning of preparation medicine of the present invention is:
Radix Polygoni Multiflori 60-150 part Semen Cassiae 80-180 part Aloe 100-200 part
Fructus Lycii 30-100 part Colla Corii Asini 30-100 part Radix Ginseng 20-80 part
Fructus Aurantii Immaturus 80-150 part Rhizoma Atractylodis Macrocephalae 20-80 part
The optimum weight proportioning of above-mentioned raw materials is:
Radix Polygoni Multiflori 80-120 part Semen Cassiae 100-150 part Aloe 120-160 part
Fructus Lycii 50-80 part Colla Corii Asini 40-80 part Radix Ginseng 20-50 part
Fructus Aurantii Immaturus 80-120 part Rhizoma Atractylodis Macrocephalae 30-50 part
Fructus Aurantii Immaturus in the aforesaid prescription, the Rhizoma Atractylodis Macrocephalae can be used in the Radix Aucklandiae, the Pericarpium Citri Reticulatae simply or two flavors replace, and Colla Corii Asini can replace with Radix Angelicae Sinensis, among Radix Polygoni Multiflori, Semen Cassiae, the Aloe simply or multi-flavor can replace with Radix Et Rhizoma Rhei.
According to the preparation process of routine, above-mentioned raw materials can be prepared into clinical medicine dosage form commonly used, for example, pill, tablet, granule, oral liquid, capsule, unguentum, Emulsion, masticatory, injection etc.
Be preferably capsule, tablet, granule.
Its effective constituent determination method of above-mentioned solid dosage forms is:
(1) ginsenoside's assay method
The preparation of reference substance solution: precision takes by weighing the ginsenoside Rg
1, each is an amount of for the Re reference substance, add methanol and make respectively among every 1ml and contain the ginsenoside Rg
10.5mg, the solution of ginsenoside Re 0.4mg, product solution in contrast;
The preparation of need testing solution: get this product and pulverize, get about 1.0g, the accurate title, decide, and is dissolved in water, and filters, and with water-saturated n-butanol extraction 4 times, extract washes twice with caustic lye of soda, and n-butyl alcohol is put evaporate to dryness in the evaporating dish, and dissolve with methanol filters, promptly;
Chromatographic condition: with octadecylsilane chemically bonded silica is filler;
Volume ratio is that 99: 400 acetonitrile-0.05% phosphoric acid solution is a mobile phase;
Detect wavelength 203nm;
Algoscopy: accurate respectively reference substance solution and each 10 μ l of need testing solution of drawing, inject hplc determination.
(2) emodin assay method
The preparation of reference substance solution: precision takes by weighing emodin reference substance 5mg, puts in the 50ml measuring bottle, with dissolve with methanol and dilution, measures 1ml, puts in the 25ml measuring bottle, adds methanol to scale, makes the solution that contains emodin 4 μ g among every 1ml, in contrast product solution;
The preparation of need testing solution: get this product and pulverize, get about 1.0g, the accurate title, decide, be dissolved in water, filter evaporate to dryness, add dissolve with methanol, filter, fling to methanol, add 2.5mol/L sulfuric acid solution 10ml, supersound process 5 minutes adds chloroform 10ml again, reflux 1 hour, cooling is in the dislocation separatory funnel, use the minimum of chloroform washing container, incorporate in the separatory funnel, divide and get chloroform layer, sour water chloroform extraction, the combined chloroform layer, with anhydrous sodium sulfate dehydration, chloroform solution is flung to, and the residue precision adds methanol 10ml, dissolving, promptly.
Chromatographic condition: with octadecylsilane chemically bonded silica is filler;
Volume ratio is that 85: 15 methanol-0.1% phosphoric acid solution is a mobile phase;
Detect wavelength 254nm;
Algoscopy: accurate respectively reference substance solution and each 5 μ l of need testing solution of drawing, inject hplc determination.
Every gram contains in the thing admittedly and contains: the ginsenoside Rg
1With ginsenoside Re's total amount 0.08mg-1.5mg, emodin 1mg-100mg.
The preparation technology of preparation of the present invention is as follows:
Colla Corii Asini is worn into fine powder (crossing 80 mesh sieves) or molten, and is standby; Radix Ginseng, Radix Polygoni Multiflori, Semen Cassiae, Aloe are adopted alcohol extracting method, 40%-80% ethanol backwash 1-3 time, and each 1-3 hour, medicinal liquid filtered, reclaims ethanol, concentrates; Fructus Lycii, Fructus Aurantii Immaturus, the Rhizoma Atractylodis Macrocephalae add 5-10 times of water, soak 0.5-3 hour, decoct 1-3 hour, add 5-10 times of water again, decoct 1-3 hour; Merge decoction liquor, filter, be evaporated to medical material: water is about 1: 1-3: 1, transfer alcohol to 40%-85%, Cryoprecipitation 12-48 hour, filter, concentrating under reduced pressure becomes extractum and alcohol reflux extractum to merge or is dry, solution and right amount of auxiliary materials are made clinical receptible various dosage forms with the conventional formulation method after adding Colla Corii Asini powder or the molten, promptly.
Drug therapy constipation of the present invention has better curative effect.For showing the therapeutical effect of medicine of the present invention to constipation, we have done a large amount of experimentatioies, below experimental example be used to further specify the present invention.
Preparation pharmacodynamics of the present invention
1. preparation mouse small intestine propulsion trial of the present invention
Purpose: observe the influence of preparation of the present invention to the mouse small intestine fltting speed.
1.1 materials and methods
1.1.1 animal:
60 of Kunming mouses, male and female half and half, body weight 18～22g raises in advance and conformed in 3rd.Nanjing University of Traditional Chinese Medicine's animal center provides, the quality certification number: SYXK (Soviet Union) 2002-0053.
1.1.2 medicine:
Preparation of the present invention is provided by Shandong southern Shandong pharmaceutical Co. Ltd.
Cisapride Xian-Janssen Pharmaceutical Ltd. produces.
Active carbon (powder) China Medicine (Group) Shanghai Chemical Reagent Co., produces.
1.1.3 instrument:
Operating theater instruments, rule, glass plate etc.
1.1.4 medicine preparation:
Being subjected to the former medicine of reagent preparation of the present invention is yellowish-brown Chinese medicine dry powder, requirement according to dosage, get preparation dry powder of the present invention with 10% charcoal end aqueous solution dispose large, medium and small three dosage.Cisapride is configured to the medicinal liquid of 0.195mg/ml as positive drug with 10% charcoal end aqueous solution.Press the 10ml/kg gastric infusion, be that dosage is 5.38g crude drug/kg (heavy dose), 1.79g crude drug/kg (middle dosage) and 0.60g crude drug/kg (low dose), cisapride 1.95mg/kg is as positive drug control group, and blank group gives 10% charcoal end aqueous solution with volume.
1.1.5 experimental technique:
Get 60 of healthy Kunming mouses, male and female half and half, fasting 24 hours is divided into 6 groups at random, 10 every group (male and female half and half).With the charcoal end is mark, is respectively matched group and is mixed with 10% suspension with normal saline; Positive group cisapride is configured to the medicinal liquid of 1.95mg/kg (0.195mg/ml) and preparation of the present invention 0.60, three dosage groups of 1.79g, 5.38g crude drug/kg with the last aqueous solution of 10% charcoal.The reagent thing that is subjected to of each dosage group all disposes with the last suspension of 10% charcoal, and with the administration of 0.1ml/10g mouse stomach, cervical vertebra dislocation in 30 minutes is put to death behind the filling stomach.The taking-up gastrointestinal of cutting open the belly immediately is tiled on the glass plate, measures displacement and the small intestinal full intestinal (from pylorus to ileocecus) of charcoal end head end in intestinal tube, calculates and advances percentage rate.With the result of the test analysis that takes statistics, each administration group and normal control group are relatively organized a t check, judge to have or not significant difference.
1.2 experimental result
1.2.1 charcoal end propulsion trial the results are shown in Table 1.
Table 1 preparation of the present invention is to the propulsive influence in mouse small intestine charcoal end (x ± SD)
| Group | Dosage (g/kg) | Number of animals (only) | Propelling rate (%) |
| Blank group cisapride preparation of the present invention | 1.95(mg/kg) 5.38 | 10 10 10 | 48.170±5.818 68.043±8.259*** 71.449±7.538*** |
| 1.79 0.60 | 10 10 | 62.678±9.820*** 58.103±9.500* |
*0.05＜P＜0.01,
* *Compare with blank group P＜0.001
Table 1 as seen, preparation 0.60,1.79 of the present invention, 5.38g crude drug/kg all have facilitation to the small intestine movement of mice wriggling, and have significant difference (
*P＜0.05
*P＜0.01
* *P＜0.001).
We find under study for action: Fructus Aurantii Immaturus, the Rhizoma Atractylodis Macrocephalae replace the curative effect there was no significant difference with the Radix Aucklandiae, Pericarpium Citri Reticulatae.
2. preparation of the present invention is to the influence of constipation model mice intestinal propulsion
Purpose: observe the influence of preparation of the present invention to constipation model mice intestinal propulsion speed.
2.1 materials and methods
2.1.1 animal:
60 of Kunming mouses, the male and female dual-purpose, body weight 18～22g raises in advance and conformed in 3rd.Nanjing University of Traditional Chinese Medicine's animal center provides, the quality certification number: SYXK (Soviet Union) 2002-0053.
2.1.2 medicine:
Preparation of the present invention is provided by Shandong southern Shandong pharmaceutical Co. Ltd.
Cisapride Xian-Janssen Pharmaceutical Ltd. produces.
Active carbon (powder) China Medicine (Group) Shanghai Chemical Reagent Co., produces.
Compound diphenoxylate Changzhou Kang Pu pharmaceutcal corporation, Ltd produce (former state-run Wujin pharmaceutical factory)
2.1.3 instrument:
Operating theater instruments, rule, glass plate etc.
2.1.4 medicine preparation:
Being subjected to the former medicine of reagent preparation of the present invention is yellowish-brown Chinese medicine dry powder, and requirement is according to dosage got the charcoal end aqueous solution medicinal liquid of preparation dry powder 3 usefulness 10% of the present invention, as large, medium and small dosage.Cisapride is configured to 0.195mg/ml with 10% charcoal end aqueous solution, press the 10ml/kg gastric infusion, and cisapride 1.95mg/kg is as the test positive drug control group, and blank group gives 10% the last aqueous solution of charcoal with volume.Modeling recurrence due to taking drug side diphenoxylate (2.5mg/ sheet) is configured to 2.5mg/ml, gets 50 and is formulated into 50ml with normal saline, presses the 10ml/kg gastric infusion, and promptly dosage is 0.025g/kg..
2.1.5 experimental technique :]
Get 60 of mices, male and female half and half, be divided into 6 groups at random, every group 10 (male and female half and half), that preparation of the present invention is established is little, in, big 3 dosage groups, be respectively 5.38,1.79,0.60g crude drug/kg dosage, establish the positive matched group of cisapride 1.95g/kg simultaneously, blank group, model group all give 10% charcoal end suspension, more than each group all irritate stomach and give mice by 10ml/kg.Each treated animal fasting 24h (freely drinking water) before the experiment, on-test,, model group, positive group and 3 dosage groups of preparation of the present invention all give compound diphenoxylate by 20mg/kg, and the blank group gives the equal-volume distilled water.Give 10% the charcoal myrrh thing suspension of containing of corresponding dosage behind the 30min respectively by 10ml/kg.Take off cervical vertebra behind the 30min and put to death animal, open the abdominal cavity and separate mesentery, clip upper end is the intestinal tube to ileocecus from pylorus, lower end, place on the glass plate, gently small intestinal is pulled into straight line, measuring intestinal tube length is " small intestinal total length ", is " prepared Chinese ink propelling length " from pylorus to prepared Chinese ink forward position, prepared Chinese ink propelling rate between the calculating group.Result of the test is learned processing by statistics, the results are shown in Table 2
2.2 experimental result
Table 2. preparation of the present invention is to the influence of mice with constipation intestinal propulsion (x ± SD)
| Group | Dosage (g/kg) | Number of animals (only) | Propelling rate (%) |
| Blank group model group cisapride preparation of the present invention | 1.95(mg/kg) 5.38 1.79 0.60 | 10 10 10 10 10 10 | 48.069±2.840 27.633±8.667### 44.488±6.514*** 46.47±10.279*** 40.528±12.950* 31.896±9.3.67 |
Compare with blank group ###P＜0.001,
*P＜0.05
*P＜0.01
* *Compare with model group P＜0.001
By table 2 as seen, preparation 1.79 of the present invention, 5.38g crude drug/kg dosage group have the effect of obvious promotion constipation model mice small intestinal peristalsis, and have significant difference (
*P＜0.05
*P＜0.01
* *P＜0.001), do not observe the effect (P＞0.05) of preparation 0.60g crude drug/kg of the present invention to constipation model mice small intestinal peristalsis
We find under study for action: Colla Corii Asini replaces curative effect constant with Radix Angelicae Sinensis.
3. preparation of the present invention is to the test of constipation model mice muck counting
Purpose: observe preparation of the present invention to the influence of defecation grain number, weight and the frequency of defecation required time and different time sections first of constipation model mice.
3.1 test material:
3.1.1 animal:
60 of Kunming mouses, male and female half and half, body weight 18～22g raises in advance and conformed in 3rd.Nanjing University of Traditional Chinese Medicine's animal center provides, the quality certification number: SYXK (Soviet Union) 2002-0053.
3.1.2 be subjected to the reagent thing:
Preparation of the present invention is provided by Shandong southern Shandong pharmaceutical Co. Ltd.
Cisapride Xian-Janssen Pharmaceutical Ltd. produces.
Active carbon (powder) China Medicine (Group) Shanghai Chemical Reagent Co., produces.
Compound diphenoxylate Changzhou Kang Pu pharmaceutcal corporation, Ltd produce (former state-run Wujin pharmaceutical factory).
3.1.3 instrument:
Mice metabolic cage etc.
3.1.3 medicine preparation:
Being subjected to the former medicine of reagent preparation of the present invention is yellowish-brown Chinese medicine dry powder, and requirement is according to dosage got preparation dry powder of the present invention and joined large, medium and small dosage with 10% charcoal end aqueous solution.Cisapride is configured to 0.195mg/ml with 10% charcoal end aqueous solution, press the 10ml/kg gastric infusion, and cisapride 1.95g/kg is as the test positive drug control group, and blank group gives 10% the last aqueous solution of charcoal with volume.Modeling recurrence due to taking drug side diphenoxylate (2.5mg/ sheet) is configured to 2.5mg/ml, gets 50 and is formulated into 50ml with normal saline, presses the 10ml/kg gastric infusion, and promptly dosage is 0.025g/kg..
3.1.4 experimental technique:
Get 60 of mices, grouping and the same 2.1.5 of medication, each treated animal fasting 12h (freely drinking water) before the experiment, on-test, model group, positive group and preparation of the present invention 5.38,1.79,0.60g crude drug/kg3 dosage group, by 20mg/kg respectively per os give the mice compound diphenoxylate, the blank group gives the equal-volume distilled water.Behind the 30min, respectively three dosage groups of positive group and preparation of the present invention are irritated stomach by 10ml/kg and give mice and contain 10% charcoal myrrh thing suspension.Model group and blank group all give isopyknic charcoal end aqueous solution of 10% that contains, 6 treated animals are all put into mice metabolic cage list cage and are observed, normal drinking-water, discharging melena first with mice is standard, write down every animal defecation required time first, and observe 2h, 4h, 6h, 8h mice accumulative total defecation grain number and defecation weight (weight in wet base) respectively, calculate stool.Result of the test is learned processing by statistics.
3.2 experimental result:
Result of the test sees Table 3
Table 3. preparation of the present invention is to constipation model mice muck counting test (x ± SD)
| Group | Dosage g/kg | Defecation time (min) first | 2h | 4h | ||||
| Defecation grain number (grain) | Defecation weight (g) | Stool (grain/h) | Defecation grain number (grain) | Defecation weight (g) | Stool (grain/h) | |||
| Blank group model group cisapride preparation of the present invention | 1.95 it is (mg/kg) large, medium and small | 22.4±15.23 288.7±95.08### 102.9±31.71*** 107.2±25.60*** 135.9±50.91*** 210.9±107.6 | 3.0±1.15 0.0±0.0### 1.8±1.14*** 1.3±1.25** 0.7±1.06 0.3±0.67 | 0.168±0.053 0.000±0.000### 0.043±0.026*** 0.027±0.027* 0.015±0.021 0.006±0.013 | 1.5±0.58 0.0±0.00### 0.90±0.57*** 0.65±0.63** 0.35±0.53 0.15±0.33 | 4.8±0.92 0.3±0.48### 1.4±0.97** 2.9±0.99*** 1.7±1.06** 0.8±0.788 | 0.24±0.043 0.006±0.01### 0.029±0.020** 0.052±0.020*** 0.033±0.02** 0.016±0.015 | 1.2±0.23 0.075±0.12### 0.80±0.31*** 0.725±0.25*** 0.425±0.26** 0.200±0.19 |
The influence that continuous table 3 preparation of the present invention is counted constipation model mice feces (x ± SD)
| Group | Dosage (g/kg) | Defecation time (min) first | 6h | 8h | ||||
| Defecation grain number (grain) | Defecation weight (g) | Stool (grain/h) | Defecation grain number (grain) | Defecation weight (g) | Stool (grain/h) | |||
| Blank group model group cisapride preparation of the present invention | 1.95 it is (mg/kg) large, medium and small | 22.4±15.23 288.7±95.08### 102.9±31.71*** 107.2±25.60*** 135.9±50.91*** 210.9±107.6 | 6.3±1.42 0.7±0.48### 4.4±1.51*** 4.1±1.44*** 2.6±1.505** 1.6± 0.516** | 0.28±0.047 0.015±0.010### 0.098±0.029*** 0.073±0.025*** 0.051±0.029** 0.03±0.010** | 1.05±0.24 0.116±0.080### 0.730±0.25*** 0.68±0.24*** 0.433±0.25** 1.6±0.51** | 7.9±1.911 0.9±0.56### 5.2±1.13*** 5.0±1.24*** 3.1±1.370*** 2.1±0.73*** | 0.32±0.058 0.020±0.014### 0.11±0.024*** 0.091±0.03*** 0.621±0.027*** 0.044±0.016** | 0.99±0.24 0.113±0.071### 0.65±0.14*** 0.63±0.15*** 0.387±0.171*** 0.262±0.09*** |
Compare with blank group ###P＜0.001
*P＜0.05
*P＜0.01
* *Compare with model group P＜0.001
By table 3 as seen, observe preparation 1.79 of the present invention, 5.38g crude drug/kg can shorten the constipation model mice first defecation time and have significant difference (
* *P＜0.001), do not observe preparation 0.60g crude drug/kg of the present invention significant difference (P＞0.05) is arranged.Each time point after preparation 5.38g crude drug of the present invention/kg administration; 1.79g after crude drug/kg administration 4,6,8 hours; 0.60 after crude drug/kg administration 8 hours to constipation model mice defecation grain number, defecation weight and frequency; 0.60g 6 hours stool all have significant difference after crude drug/kg administration; (
*P＜0.05
*P＜0.01
* *P＜0.001), do not observe after preparation 1.79g crude drug of the present invention/kg administration 2 hours; 0.60g after crude drug/kg administration 2,4 hours to constipation model mice defecation grain number, defecation weight and frequency; 0.60g constipation model mice defecation grain number and weight had significant difference (P＞0.05) in 6 hours after crude drug/kg administration.
We find in the research: with among Radix Polygoni Multiflori, Semen Cassiae, the Aloe simply or multi-flavor replace curative effect constant with Radix Et Rhizoma Rhei.
4. preparation of the present invention is to the influence of the phenol red content of rat stomach enteral
4.1 test material and method:
4.1.1 animal:
40 of SD rats, the male and female dual-purpose, body weight 180～220g raises in advance and conformed in 3rd.Nanjing University of Traditional Chinese Medicine's animal center provides, the quality certification number: SYXK (Soviet Union) 2002-0053.
4.1.2 medicine:
1. preparation of the present invention is provided by Shandong southern Shandong pharmaceutical Co. Ltd
2. cisapride Xian-Janssen Pharmaceutical Ltd. produces
3. phenol red Shanghai reagent three factories
4. sodium hydroxide Shanghai reagent four factories
5. pilot plant of barium hydroxide Shanghai Chemistry High School
6. barium sulfate Shanghai development chemical reagent work
4.1.3 instrument:
1. electronic balance, Shanghai balance equipment factory
2. centrifuge Germany
3. Spctiamax190 U.S. MD company
4.1.4 medicine configuration:
Being subjected to the former medicine of reagent preparation of the present invention is yellowish-brown Chinese medicine dry powder, and requirement is according to dosage got dry powder and joined heavy dose, middle dosage, low dose with distilled water.Cisapride is configured to the medicinal liquid of 0.135mg/ml as positive drug.Press the 10ml/kg gastric infusion, be that dosage is 3.73g crude drug/kg (heavy dose), 1.24g crude drug/kg (middle dosage) and 0.41g crude drug/kg (low dose), cisapride 1.35mg/kg is as the test positive drug control group, and blank group gives the normal saline with volume.Phenol red dextrin: the ratio heating furnishing dextrin that adds 1g flour with 10% phenol red liquid in every 15ml.Phenol red solution: accurately dispose the 1.0mg% phenol red solution, respectively split 10 pipes from 0～9ml, add 0.1%NaOH then successively and make each pipe capacity reach 10ml, fully mix with the degree of passing of 1ml.
4.1.5 experimental technique:
Get 50 of SD rats, male and female half and half, be divided into four groups at random, every group 10 (male and female half and half) after 48 hours, begin experiment on an empty stomach, be subjected to reagent thing group: 0.41,1.24 and 3.73g crude drug/kg, positive drug group cisapride 1.35mg/kg, matched group gives the normal saline with volume, irritates stomach with 10ml/kg respectively and gives rat.1.5h after the administration, oral phenol red paste 1ml/100g respectively.The sacrificed by decapitation animal opens abdomen along ventrimeson behind the 30min, connects to prick cardia, pylorus and ileocecus, free then stomach, small intestinal.Little intestinal segment is divided into 6 sections, cuts off successively, and with the distilled water flushing content, last standardize solution is 6ml, then adds the Ba (OH) of 0.15nmol/l in each pipe respectively
22ml fully mixed the back static 3～5 minutes, respectively added 2ml 5%ZnSO again
2After firmly shaking up, with the centrifugal 10min of 3000r/min, respectively get and ask liquid 4ml, add 10%NaOH0.5ml, mix back photometry density value, contrast phenol red standard curve, check in the enteral phenol red content of each section, thereby can push away the row function situation by quantitative judgement rat small intestine, push away the amplitude of variation of function to show gastrointestinal row.By mensuration, and push away the indication of changes of function as gastrointestinal row with it to phenol red residual quantity in different group animal stomaches, the intestinal.
4.2 experimental result:
Result of the test sees Table 4
Table 4. medicine is to the influence of the phenol red content of rat stomach enteral
| Group | Dosage (g/kg) | Mus number (only) | Intestinal phenol red concentration (mg/ml) | |||||
| The I section | The II section | The III section | The IV section | The V section | The VI section | |||
| Blank Cisapride preparation of the present invention preparation of the present invention preparation of the present invention | 1.35(mg/kg) 3.73 1.24 0.41 | 10 10 10 10 10 | 2.662±0.339 1.978±0.155*** 1.924±0.166*** 1.907±0.195*** 1.982±0.384*** | 2.524±0.323 2.055±0.221** 1.975±0.226** 1.989±0.159** 2.036±0.397* | 2.154±0.325 2.568±0.340* 2.617±0.384** 2.499±0.394* 2.139±0.376 | 2.093±0.232 2.770±0.496** 3.132±0.844** 2.728±0.671* 2.602±1.246 | 1.968±0.219 2.816±0.406*** 2.723±0.748* 2.266±0.299* 2.076±0.455 | 1.843±0.148 2.500±0.504** 2.143±0.286* 2.128±0.0.289* 2.060±0.579 |
Administration group and blank group are relatively
*P＜0.05
*P＜0.01
* *P＜0.001
Above result shows, preparation 3.73g of the present invention, 1.24g crude drug/kg dosage group phenol red content of each intestinal segment and blank group more all have significant difference (
*P＜0.05
*P＜0.01
* *P＜0.001), 0.41g crude drug/kg dosage group is organized with blank at I, II intestinal segment relatively significant difference (
*P＜0.05
* *P＜0.001), thus can quantitatively judge preparation of the present invention pushes away row function to rat small intestine obvious facilitation is arranged.
5. preparation of the present invention is to the influence of the stripped ileum of rabbit
Observe contraction frequency and the amplitude influence of medicine to the spontaneous activity of rabbit duodenum.
5.1 test material and method:
5.1.1 animal:
Japan large ear rabbit, body weight 4～6kg raises in advance and conformed in 3rd.Nanjing University of Traditional Chinese Medicine's animal center provides, the quality certification number: SYXK (Soviet Union) 2002-0053.
5.1.2 medicine:
1. preparation of the present invention is by being provided by Shandong southern Shandong pharmaceutical Co. Ltd.
2. cisapride Xian-Janssen Pharmaceutical Ltd. produces.
3. atropine sulfate Nantong pharmaceutical factory.
Other reagent are chemical pure commercially available product.
5.1.3 instrument:
1. PowerLab Australia AD instrument company
2. microsyringe
3. centrifuge
5.1.4 medicine preparation:
Requirement according to dosage; get preparation dry powder of the present invention (1g crude drug/0.29g dry powder) 2.5g with distilled water diluting to 20ml (8.62g crude drug/ml); the centrifuging and taking supernatant is heavy dose of; therefrom get 8ml with distilled water diluting to 24ml (2.87g crude drug/ml); therefrom get 10ml; with distilled water diluting to 30ml (0.96g crude drug/ml), therefrom get 10ml, with distilled water diluting to 30ml (0.32g crude drug/ml); 10ul adds bath, and final concentration is respectively: 5.747 * 10
-3, 1.916 * 10
-3, 6.385 * 10
-4, 2.128 * 10
-4G/ml.
5.1.5 experimental technique:
Get body weight and be the Japan large ear rabbit of (1000 ± 100) g, male and female all can, after water 24h is can't help in fasting, take off cervical vertebra and put to death.Cut open the belly, cut off mesentery with operating scissors and take out ileum, place plate, soft flushing several, two ends are pricked with toe-in.The ileum that will exsomatize hangs in the Magnus' bath that fills Kreb ' sShi liquid, and an end ties up on the L type breather, is fixed, and supplies with to contain 5%CO
2Oxygen, the other end is fixed on the pressure transducer, preset the load 1g, 37.5 ℃ of bath temperature are stablized 1h, trace with MacLab.After treating that the spontaneous rhythm and pace of moving things recovers, trace baseline, (final concentration is 6.7 * 10 to give the atropine sulfate solution of the fresh configuration of an amount of concentration
-7), trace the intestinal tube shrinkage curve, trace end after, Kreb ' s liquid flushing 2～3 times, each 5min at interval; After treating that the spontaneous rhythm and pace of moving things recovers, give the certain density reagent thing that is subjected to, the shrinkage curve of the same mensuration atropine sulfate is measured the contraction height that adds behind the histamine, calculates the amplitude slip.
5.1.6 experimental result:
Table 5. preparation of the present invention is to the exsomatize influence (n=6 of x ± SD) of ileum of rabbit
| Group | Formulation concentrations of the present invention (the g crude drug/ml) | The amplitude slip | Suppression ratio (%) |
| Atropine atropine+cisapride atropine+preparation of the present invention | 6.7×10 -7 2.5× 10 -3(mg/ml) 5.747×10 -3 1.916×10 -3 6.385×10 -4 2.128×10 -4 | 40.71±18.27 6.46±2.35 ** 8.44±8.21 ** 13.14±7.63 ** 15.57±11.81 * 23.65±11.71 | -- 84.1 79.3 67.7 61.8 41.9 |
Compare with the atropine group
*, p＜O.05,
*P＜O.01 compare with the atropine group
The result shows that preparation of the present invention all can strengthen the shrinkage amplitude of intestinal smooth muscle spontaneous activity by the antagonism atropine, and the result adopts paired t-test before and after the administration, and difference has significance (＜0.01).But contraction frequency there is not influence (P＞0.05).Point out preparation 5.747 * 10 of the present invention
-3, 1.916 * 10
-3, 6.385 * 10
-4All can excited gastrointestinal smooth muscle.
Following embodiment is further openly the present invention, need to prove that these embodiment only for optimal way of the present invention, do not limit the scope of protection of present invention.
Embodiment 1
600 parts of 500 portions of Aloes of 25 parts of Semen Cassiaes of Radix Polygoni Multiflori
100 parts of 150 parts of Radix Ginsengs of 150 parts of Colla Corii Asini of Fructus Lycii
Above Six-element medicine, Colla Corii Asini are worn into fine powder (crossing 80 mesh sieves), and be standby; Radix Ginseng, Radix Polygoni Multiflori, Semen Cassiae, Aloe are adopted alcohol extracting method; Add medical material 10+8 and doubly measure 50% ethanol backwash 2 times, each 1.5 hours; Fructus Lycii adds 8 times of water, steeps 1 hour, decocts 1.5 hours, adds 6 times of water again, decocts 1.5 hours; Merge decoction liquor, filter, be evaporated to medical material: water is about 2: 1, merges with backwash liquid, transfers alcohol to 60%, Cryoprecipitation 24 hours, and sucking filtration, concentrating under reduced pressure becomes extractum, adds Colla Corii Asini powder and right amount of auxiliary materials system granule, drying, the system granule, packing promptly gets granule.
Its effective constituent determination method:
Ginsenoside's assay method
The preparation of reference substance solution: precision takes by weighing the ginsenoside Rg
1, each is an amount of for the Re reference substance, add methanol and make respectively among every 1ml and contain the ginsenoside Rg
10.5mg, the solution of ginsenoside Re 0.4mg, product solution in contrast;
The preparation of need testing solution: get this product content and pulverize, get about 1.0g, the accurate title, decide, and is dissolved in water, and filters, and with water-saturated n-butanol extraction 4 times, extract washes twice with caustic lye of soda, and n-butyl alcohol is put evaporate to dryness in the evaporating dish, and dissolve with methanol filters, promptly;
Chromatographic condition: with octadecylsilane chemically bonded silica is filler;
Volume ratio is that 99: 400 acetonitrile-0.05% phosphoric acid solution is a mobile phase;
Detect wavelength 203nm;
Algoscopy: accurate respectively reference substance solution and each 10 μ l of need testing solution of drawing, inject hplc determination.
The emodin assay method
The preparation of reference substance solution: precision takes by weighing emodin reference substance 5mg, puts in the 50ml measuring bottle, with dissolve with methanol and dilution, measures 1ml, puts in the 25ml measuring bottle, adds methanol to scale, makes the solution that contains emodin 4 μ g among every 1ml, in contrast product solution;
The preparation of need testing solution: get this product content and pulverize, get about 1.0g, the accurate title, decide, be dissolved in water, filter evaporate to dryness, add dissolve with methanol, filter, fling to methanol, add 2.5mol/L sulfuric acid solution 10ml, supersound process 5 minutes adds chloroform 10ml again, reflux 1 hour, cooling is in the dislocation separatory funnel, use the minimum of chloroform washing container, incorporate in the separatory funnel, divide and get chloroform layer, sour water chloroform extraction, the combined chloroform layer, with anhydrous sodium sulfate dehydration, chloroform solution is flung to, and the residue precision adds methanol 10ml, dissolving, promptly.
Chromatographic condition: with octadecylsilane chemically bonded silica is filler;
Volume ratio is that 85: 15 methanol-0.1% phosphoric acid solution is a mobile phase;
Detect wavelength 254nm;
Algoscopy: accurate respectively reference substance solution and each 5 μ l of need testing solution of drawing, inject hplc determination.
Measurement result, every gram contains in the thing admittedly and contains: the ginsenoside Rg
1With ginsenoside Re's total amount 1.0mg, emodin 50mg.
Embodiment 2
600 parts of 30 portions of Aloes of 400 parts of Semen Cassiaes of Radix Polygoni Multiflori
100 parts of 150 parts of Radix Ginsengs of 150 parts of Colla Corii Asini of Fructus Lycii
Colla Corii Asini is worn into fine powder (crossing 80 mesh sieves), and is standby; Radix Ginseng, Radix Polygoni Multiflori, Semen Cassiae, Aloe are adopted alcohol extracting method, 40% ethanol backwash 1 time, and each 3 hours, medicinal liquid filtered, reclaims ethanol, concentrates; Fructus Lycii adds 5 times of water, soaks 0.5 hour, decocts 1 hour, adds 5 times of water again, decocts 1 hour; Merge decoction liquor, filter, be evaporated to medical material: water is about 3: 1; transfer alcohol to 40%; Cryoprecipitation 48 hours filters, and concentrating under reduced pressure becomes extractum and alcohol reflux extractum to merge; dry; above-mentioned fine powder adds Colla Corii Asini powder and an amount of dextrin, Icing Sugar system soft material, and granulator is granulated, drying; packing promptly gets granule.
Effective constituent determination method: the same
Measurement result, every gram contains in the thing admittedly and contains: the ginsenoside Rg
1With ginsenoside Re's total amount 1.5mg, emodin 1mg.
Embodiment 3
30 parts of 500 portions of Aloes of 400 parts of Semen Cassiaes of Radix Polygoni Multiflori
100 parts of 150 parts of Radix Ginsengs of 150 parts of Colla Corii Asini of Fructus Lycii
Colla Corii Asini is worn into fine powder (crossing 80 mesh sieves), and is standby; Radix Ginseng, Radix Polygoni Multiflori, Semen Cassiae, Aloe are adopted alcohol extracting method, 80% ethanol backwash 3 times, and each 2 hours, medicinal liquid filtered, reclaims ethanol, concentrates; Fructus Lycii, add 10 times of water, soaked 3 hours, decocted 1.5 hours, add 10 times of water again, decocted 3 hours; Merge decoction liquor, filter, be evaporated to medical material: water is about 1: 1, transfers alcohol to 85%, and Cryoprecipitation 12 hours filters, and concentrating under reduced pressure becomes extractum and alcohol reflux extractum to merge, and drying adds the Colla Corii Asini powder and adds right amount of auxiliary materials system granule, and the fill capsule promptly gets capsule.
Effective constituent determination method: the same
Measurement result, every gram contains in the thing admittedly and contains: the ginsenoside Rg
1With ginsenoside Re's total amount 1.0mg, emodin 25mg.
Embodiment 4
600 parts of 500 portions of Aloes of 400 parts of Semen Cassiaes of Radix Polygoni Multiflori
100 parts of 150 parts of Radix Ginsengs of 30 parts of Colla Corii Asini of Fructus Lycii
Colla Corii Asini is worn into fine powder (crossing 80 mesh sieves), and is standby; Radix Ginseng, Radix Polygoni Multiflori, Semen Cassiae, Aloe are adopted alcohol extracting method, 50% ethanol backwash 2 times, and each 2 hours, medicinal liquid filtered, reclaims ethanol, concentrates; Fructus Lycii adds 6 times of water, soaks 2.5 hours, decocts 2 hours, adds 5 times of water again, decocts 2.5 hours; Merge decoction liquor, filter, be evaporated to medical material: water is about 1.5: 1, transfers alcohol to 50%, and Cryoprecipitation 36 hours filters, and concentrating under reduced pressure becomes extractum and alcohol reflux extractum to merge, and drying adds the Colla Corii Asini powder, right amount of auxiliary materials system granule, and tabletting promptly gets tablet.
Effective constituent determination method: the same
Measurement result, every gram contains in the thing admittedly and contains: the ginsenoside Rg
1With ginsenoside Re's total amount 0.1mg, emodin 75mg.
Embodiment 5
600 parts of 500 portions of Aloes of 400 parts of Semen Cassiaes of Radix Polygoni Multiflori
100 parts of 30 parts of Radix Ginsengs of 150 parts of Colla Corii Asini of Fructus Lycii
Colla Corii Asini is worn into fine powder (crossing 80 mesh sieves) or molten, and is standby; Radix Ginseng, Radix Polygoni Multiflori, Semen Cassiae, Aloe are adopted alcohol extracting method, 55% ethanol backwash 3 times, and each 1 hour, medicinal liquid filtered, reclaims ethanol, concentrates; Fructus Lycii adds 8 times of water, soaks 0.5 hour, decocts 3 hours, adds 6 times of water again, decocts 2 hours; Merge decoction liquor, filter, be evaporated to medical material: water is about 2.5: 1, transfers alcohol to 55%, and Cryoprecipitation 48 hours filters, and concentrating under reduced pressure becomes extractum and alcohol reflux extractum to merge, and drying adds Colla Corii Asini powder and appropriate amount of starch, and the general ball of making promptly gets pill.
Effective constituent determination method: the same
Measurement result, every gram contains in the thing admittedly and contains: the ginsenoside Rg
1With ginsenoside Re's total amount 0.3mg, emodin 15mg.
Embodiment 6
600 parts of 500 portions of Aloes of 400 parts of Semen Cassiaes of Radix Polygoni Multiflori
20 parts of 150 parts of Radix Ginsengs of 150 parts of Colla Corii Asini of Fructus Lycii
Colla Corii Asini is worn into fine powder (crossing 80 mesh sieves), and is standby; Radix Ginseng, Radix Polygoni Multiflori, Semen Cassiae, Aloe are adopted alcohol extracting method, 60% ethanol backwash 2 times, and each 2.5 hours, medicinal liquid filtered, reclaims ethanol, concentrates; 10 times of water of Fructus Lycii soaked 3 hours, decocted 1 hour, added 8 times of water again, decocted 1 hour; Merge decoction liquor, filter, be evaporated to medical material: water is about 3: 1, transfers alcohol to 60%, and Cryoprecipitation 48 hours filters, and concentrating under reduced pressure becomes extractum and alcohol reflux extractum to merge, and drying is gone into the Colla Corii Asini powder, and mixing sieves, and promptly gets powder.
Effective constituent determination method: the same
Measurement result, every gram contains in the thing admittedly and contains: the ginsenoside Rg
1With ginsenoside Re's total amount 0.08mg, emodin 65mg.
Embodiment 7
600 parts of 500 portions of Aloes of 25 parts of Semen Cassiaes of Radix Polygoni Multiflori
100 parts of 150 parts of Radix Ginsengs of 150 parts of Colla Corii Asini of Fructus Lycii
100 parts of 200 parts of Rhizoma Atractylodis Macrocephalaes of Fructus Aurantii Immaturus
The Colla Corii Asini molten, standby; Radix Ginseng, Radix Polygoni Multiflori, Semen Cassiae, Aloe are adopted alcohol extracting method, 65% ethanol backwash 2 times, and each 1.5 hours, medicinal liquid filtered, reclaims ethanol, concentrates; Fructus Lycii, Fructus Aurantii Immaturus, the Rhizoma Atractylodis Macrocephalae add 9 times of water, soak 1.5 hours, decoct 2 hours, add 7 times of water again, decoct 1.5 hours; Merge decoction liquor, filter, be evaporated to medical material: water is about 3: 1, transfers alcohol to 75%, Cryoprecipitation 48 hours filters, and concentrating under reduced pressure becomes extractum and alcohol reflux extractum to merge, solution after the adding Colla Corii Asini powder molten, add 10 times of water gagings, stir, Cryoprecipitation 48 hours filters, filtrate concentrates, and to regulating PH to 8, adds 0.1% active carbon, heated and boiled 30 minutes, filter, add to the full amount of water for injection, filter fine straining, the embedding sterilization, check promptly gets injection.
Embodiment 8
600 parts of 30 portions of Aloes of 400 parts of Semen Cassiaes of Radix Polygoni Multiflori
100 parts of 3150 parts of Radix Ginsengs of 150 parts of Colla Corii Asini of Fructus Lycii
100 parts of 200 parts of Rhizoma Atractylodis Macrocephalaes of Fructus Aurantii Immaturus
The Colla Corii Asini molten, standby; Radix Ginseng, Radix Polygoni Multiflori, Semen Cassiae, Aloe are adopted alcohol extracting method, 70% ethanol backwash 2 times, and each 2 hours, medicinal liquid filtered, reclaims ethanol, concentrates; Fructus Lycii, Fructus Aurantii Immaturus, the Rhizoma Atractylodis Macrocephalae add 8 times of water, soak 1.5 hours, decoct 2.5 hours, add 5 times of water again, decoct 2 hours; Merge decoction liquor, filter, be evaporated to medical material: water is about 2: 1, transfers alcohol to 80%, Cryoprecipitation 48 hours filters, and concentrating under reduced pressure becomes extractum and alcohol reflux extractum to merge solution after the adding Colla Corii Asini molten, adds 10 times of water, stir, Cryoprecipitation 48 hours filters, and filtrate concentrates, to regulating PH to 4, add 0.1% active carbon, heated and boiled 30 minutes is filtered, add to the full amount of water for injection, filter fine straining, lyophilization is aseptic subpackaged, and check promptly gets the powder pin.
Embodiment 10
30 parts of 500 portions of Aloes of 400 parts of Semen Cassiaes of Radix Polygoni Multiflori
100 parts of 150 parts of Radix Ginsengs of 150 parts of Colla Corii Asini of Fructus Lycii
100 parts of 200 parts of Rhizoma Atractylodis Macrocephalaes of Fructus Aurantii Immaturus
The Colla Corii Asini molten, standby; Radix Ginseng, Radix Polygoni Multiflori, Semen Cassiae, Aloe are adopted alcohol extracting method, 75% ethanol backwash 2 times, and each 1.5 hours, medicinal liquid filtered, reclaims ethanol, concentrates; Fructus Lycii, Fructus Aurantii Immaturus, the Rhizoma Atractylodis Macrocephalae add 8 times of water, soak 2.5 hours, decoct 2 hours, add 6 times of water again, decoct 1.5 hours; Merge decoction liquor, filter, be evaporated to medical material: water is about 3: 1, transfers alcohol to 85%, Cryoprecipitation 48 hours filters, and concentrating under reduced pressure becomes extractum and alcohol reflux extractum to merge solution after the adding Colla Corii Asini powder molten, adds 10 times of water, Cryoprecipitation 48 hours filters, and filtrate concentrates, to regulating PH to 7, add 0.1% active carbon, heated and boiled 30 minutes, filter, add to the full amount of water for injection, filter, fine straining, the embedding sterilizing test promptly gets and infuses.
Embodiment 11
600 parts of 500 portions of Aloes of 400 parts of Semen Cassiaes of Radix Polygoni Multiflori
100 parts of 150 parts of Radix Ginsengs of 30 parts of Colla Corii Asini of Fructus Lycii
100 parts of 200 parts of Rhizoma Atractylodis Macrocephalaes of Fructus Aurantii Immaturus
The Colla Corii Asini molten, standby; Radix Ginseng, Radix Polygoni Multiflori, Semen Cassiae, Aloe are adopted alcohol extracting method, 80% ethanol backwash 2 times, and each 2 hours, medicinal liquid filtered, reclaims ethanol, concentrates; Fructus Lycii, Fructus Aurantii Immaturus, the Rhizoma Atractylodis Macrocephalae add 10 times of water, soak 0.5 hour, decoct 2 hours, add 8 times of water again, decoct 1.5 hours; Merge decoction liquor, filter, be evaporated to medical material: water is about 3: 1, transfers alcohol to 65%, and Cryoprecipitation 36 hours filters, and concentrating under reduced pressure becomes extractum and alcohol reflux extractum to merge to add solution after the Colla Corii Asini powder molten to add the ethanol of normal concentration, stirs, and filtration promptly gets tincture.
Embodiment 12
600 parts of 500 portions of Aloes of 400 parts of Semen Cassiaes of Radix Polygoni Multiflori
100 parts of 30 parts of Radix Ginsengs of 150 parts of Colla Corii Asini of Fructus Lycii
100 parts of 200 parts of Rhizoma Atractylodis Macrocephalaes of Fructus Aurantii Immaturus
Colla Corii Asini is worn into fine powder (crossing 80 mesh sieves), and is standby; Radix Ginseng, Radix Polygoni Multiflori, Semen Cassiae, Aloe are adopted alcohol extracting method, 60% ethanol backwash 2 times, and each 1.5 hours, medicinal liquid filtered, reclaims ethanol, concentrates; Fructus Lycii, Fructus Aurantii Immaturus, the Rhizoma Atractylodis Macrocephalae add 8 times of water, soak 1 hour, decoct 3 hours, add 6 times of water again, decoct 3 hours; Merge decoction liquor, filter, be evaporated to medical material: water is about 1: 1, transfer alcohol to 80%, Cryoprecipitation 48 hours filters, concentrating under reduced pressure becomes extractum and alcohol reflux extractum to merge, and drying adds Colla Corii Asini powder mixing, with the substrate heating and melting, add dry medicated powder, mixing, impouring scribbles in the bolt mould of releasing agent, cooling is taken out, and promptly gets suppository.
Embodiment 13
600 parts of 500 portions of Aloes of 400 parts of Semen Cassiaes of Radix Polygoni Multiflori
20 parts of 150 parts of Radix Ginsengs of 150 parts of Colla Corii Asini of Fructus Lycii
100 parts of 200 parts of Rhizoma Atractylodis Macrocephalaes of Fructus Aurantii Immaturus
The Colla Corii Asini molten, standby; Radix Ginseng, Radix Polygoni Multiflori, Semen Cassiae, Aloe are adopted alcohol extracting method, 50% ethanol backwash 2 times, and each 2 o'clock, medicinal liquid filtered, reclaims ethanol, concentrates; Fructus Lycii, Fructus Aurantii Immaturus, the Rhizoma Atractylodis Macrocephalae add 10 times of water, soak 2 hours, decoct 2 hours, add 8 times of water again, decoct 2 hours; Merge decoction liquor, filter, be evaporated to medical material: water is about 2: 1, transfers alcohol to 50%, Cryoprecipitation 12 hours filters, and concentrating under reduced pressure becomes extractum and alcohol reflux extractum to merge solution after the adding Colla Corii Asini powder molten, it is an amount of to add water, filters, and other gets sucrose and adds an amount of heated and boiled of water, dissolving is filtered, and concentrates and makes syrup, with above-mentioned concentrated solution mixing, boil, put cold, add antiseptic and essence, thin up promptly gets syrup.
Embodiment 14
600 parts of 500 portions of Aloes of 400 parts of Semen Cassiaes of Radix Polygoni Multiflori
100 parts of 150 parts of Radix Ginsengs of 150 parts of Colla Corii Asini of Fructus Lycii
100 parts of 50 parts of Rhizoma Atractylodis Macrocephalaes of Fructus Aurantii Immaturus
The Colla Corii Asini molten, standby; Radix Ginseng, Radix Polygoni Multiflori, Semen Cassiae, Aloe are adopted alcohol extracting method, 55% ethanol backwash 2 times, and each 1.5 hours, medicinal liquid filtered, reclaims ethanol, concentrates; Fructus Lycii, Fructus Aurantii Immaturus, the Rhizoma Atractylodis Macrocephalae add 8 times of water, soak 1 hour, decoct 1.5 hours, add 6 times of water again, decoct 1.5 hours; Merge decoction liquor, filter, be evaporated to medical material: water is about 3: 1, transfers alcohol to 65%, Cryoprecipitation 48 hours, filter, concentrating under reduced pressure becomes extractum and alcohol reflux extractum to merge to add solution after the Colla Corii Asini molten, and it is an amount of to add water, and filtration adds water system full dose, filter, fill, sterilization promptly gets mixture.
Embodiment 15
600 parts of 500 portions of Aloes of 400 parts of Semen Cassiaes of Radix Polygoni Multiflori
100 parts of 150 parts of Radix Ginsengs of 150 parts of Colla Corii Asini of Fructus Lycii
20 parts of 200 parts of Rhizoma Atractylodis Macrocephalaes of Fructus Aurantii Immaturus
Colla Corii Asini is worn into fine powder (crossing 80 mesh sieves), and is standby; Radix Ginseng, Radix Polygoni Multiflori, Semen Cassiae, Aloe are adopted alcohol extracting method, 60% ethanol backwash 2 times, and each 1.5 hours, medicinal liquid filtered, reclaims ethanol, concentrates; Fructus Lycii, Fructus Aurantii Immaturus, the Rhizoma Atractylodis Macrocephalae add 8 times of water, soak 2.5 hours, decoct 2 hours, add 6 times of water again, decoct 2 hours; Merge decoction liquor; filter, be evaporated to medical material: water is about 3: 1, transfers alcohol to 55%; Cryoprecipitation 12 hours; filter, concentrating under reduced pressure becomes extractum and alcohol reflux extractum to merge drying; add Colla Corii Asini powder mixing; above-mentioned fine powder adds an amount of dextrin, magnesium stearate, stevioside, mixing, with dry granulation mechanism grain, promptly.
Embodiment 16
200 parts of 180 portions of Aloes of 60 parts of Semen Cassiaes of Radix Polygoni Multiflori
80 parts of 100 parts of Radix Ginsengs of 100 parts of Colla Corii Asini of Fructus Lycii
80 parts of 150 parts of Rhizoma Atractylodis Macrocephalaes of Fructus Aurantii Immaturus.
Colla Corii Asini is worn into fine powder (crossing 80 mesh sieves), and is standby; Radix Ginseng, Radix Polygoni Multiflori, Semen Cassiae, Aloe are adopted alcohol extracting method, 60% ethanol backwash 2 times, and each 1.5 hours, medicinal liquid filtered, reclaims ethanol, concentrates; Fructus Lycii, Fructus Aurantii Immaturus, the Rhizoma Atractylodis Macrocephalae add 8 times of water, soak 2.5 hours, decoct 2 hours, add 6 times of water again, decoct 2 hours; Merge decoction liquor; filter, be evaporated to medical material: water is about 3: 1, transfers alcohol to 55%; Cryoprecipitation 12 hours; filter, concentrating under reduced pressure becomes extractum and alcohol reflux extractum to merge drying; add Colla Corii Asini powder mixing; above-mentioned fine powder adds an amount of dextrin, magnesium stearate, stevioside, mixing, with dry granulation mechanism grain, promptly.
Embodiment 17
200 parts of 80 portions of Aloes of 150 parts of Semen Cassiaes of Radix Polygoni Multiflori
80 parts of 100 parts of Radix Ginsengs of 100 parts of Colla Corii Asini of Fructus Lycii
80 parts of 150 parts of Rhizoma Atractylodis Macrocephalaes of Fructus Aurantii Immaturus.
Colla Corii Asini is worn into fine powder (crossing 80 mesh sieves), and is standby; Radix Ginseng, Radix Polygoni Multiflori, Semen Cassiae, Aloe are adopted alcohol extracting method, 60% ethanol backwash 2 times, and each 1.5 hours, medicinal liquid filtered, reclaims ethanol, concentrates; Fructus Lycii, Fructus Aurantii Immaturus, the Rhizoma Atractylodis Macrocephalae add 8 times of water, soak 2.5 hours, decoct 2 hours, add 6 times of water again, decoct 2 hours; Merge decoction liquor, filter, be evaporated to medical material: water is about 3: 1; transfer alcohol to 55%, Cryoprecipitation 12 hours filters; concentrating under reduced pressure becomes extractum and alcohol reflux extractum to merge; drying adds Colla Corii Asini powder mixing, and above-mentioned fine powder adds an amount of dextrin, Icing Sugar system soft material; granulator is granulated; drying, packing promptly gets granule.
Embodiment 18
100 parts of 180 portions of Aloes of 150 parts of Semen Cassiaes of Radix Polygoni Multiflori
80 parts of 100 parts of Radix Ginsengs of 100 parts of Colla Corii Asini of Fructus Lycii
80 parts of 150 parts of Rhizoma Atractylodis Macrocephalaes of Fructus Aurantii Immaturus.
Colla Corii Asini is worn into fine powder (crossing 80 mesh sieves), and is standby; Radix Ginseng, Radix Polygoni Multiflori, Semen Cassiae, Aloe are adopted alcohol extracting method, 60% ethanol backwash 2 times, and each 2.5 hours, medicinal liquid filtered, reclaims ethanol, concentrates; 10 times of water of Fructus Lycii soaked 3 hours, decocted 1 hour, added 8 times of water again, decocted 1 hour; Merge decoction liquor, filter, be evaporated to medical material: water is about 1: 1, transfers alcohol to 60%, Cryoprecipitation 48 hours, filter, concentrating under reduced pressure becomes extractum and alcohol reflux extractum to merge, and drying adds Colla Corii Asini powder dextrin mixing, the ethanol system soft material with 65%, the system granule, drying, packing, promptly.
Embodiment 19
200 parts of 180 portions of Aloes of 150 parts of Semen Cassiaes of Radix Polygoni Multiflori
80 parts of 100 parts of Radix Ginsengs of 30 parts of Colla Corii Asini of Fructus Lycii
80 parts of 150 parts of Rhizoma Atractylodis Macrocephalaes of Fructus Aurantii Immaturus.
Colla Corii Asini is worn into fine powder (crossing 80 mesh sieves), and is standby; Radix Ginseng, Radix Polygoni Multiflori, Semen Cassiae, Aloe are adopted alcohol extracting method, 60% ethanol backwash 2 times, and each 2.5 hours, medicinal liquid filtered, reclaims ethanol, concentrates; 10 times of water of Fructus Lycii soaked 3 hours, decocted 1 hour, added 8 times of water again, decocted 1 hour; Merge decoction liquor, filter, be evaporated to medical material: water is about 1: 1, transfers alcohol to 60%, Cryoprecipitation 48 hours, filter, concentrating under reduced pressure becomes extractum and alcohol reflux extractum to merge, and drying adds Colla Corii Asini powder dextrin mixing, the ethanol system soft material with 65%, the system granule, drying, encapsulated, packing, promptly.
Embodiment 20
200 parts of 180 portions of Aloes of 150 parts of Semen Cassiaes of Radix Polygoni Multiflori
80 parts of 30 parts of Radix Ginsengs of 100 parts of Colla Corii Asini of Fructus Lycii
80 parts of 150 parts of Rhizoma Atractylodis Macrocephalaes of Fructus Aurantii Immaturus.
Colla Corii Asini is worn into fine powder (crossing 80 mesh sieves), and is standby; Radix Ginseng, Radix Polygoni Multiflori, Semen Cassiae, Aloe are adopted alcohol extracting method, 60% ethanol backwash 2 times, and each 1.5 hours, medicinal liquid filtered, reclaims ethanol, concentrates; Fructus Lycii, Fructus Aurantii Immaturus, the Rhizoma Atractylodis Macrocephalae add 8 times of water, soak 2.5 hours, decoct 2 hours, add 6 times of water again, decoct 2 hours; Merge decoction liquor, filter, be evaporated to medical material: water is about 3: 1; transfer alcohol to 55%, Cryoprecipitation 12 hours filters; concentrating under reduced pressure becomes extractum and alcohol reflux extractum to merge; drying adds Colla Corii Asini powder mixing, and above-mentioned fine powder adds an amount of dextrin, magnesium stearate, stevioside, mixing; with dry granulation mechanism grain; encapsulated, packing, promptly.
Embodiment 21
200 parts of 180 portions of Aloes of 150 parts of Semen Cassiaes of Radix Polygoni Multiflori
20 parts of 100 parts of Radix Ginsengs of 100 parts of Colla Corii Asini of Fructus Lycii
80 parts of 150 parts of Rhizoma Atractylodis Macrocephalaes of Fructus Aurantii Immaturus.Colla Corii Asini is worn into fine powder (crossing 80 mesh sieves), and is standby; Radix Ginseng, Radix Polygoni Multiflori, Semen Cassiae, Aloe are adopted alcohol extracting method, 60% ethanol backwash 2 times, and each 1.5 hours, medicinal liquid filtered, reclaims ethanol, concentrates; Fructus Lycii, Fructus Aurantii Immaturus, the Rhizoma Atractylodis Macrocephalae add 8 times of water, soak 2.5 hours, decoct 2 hours, add 6 times of water again, decoct 2 hours; Merge decoction liquor, filter, be evaporated to medical material: water is about 3: 1; transfer alcohol to 55%, Cryoprecipitation 12 hours filters; concentrating under reduced pressure becomes extractum and alcohol reflux extractum to merge; drying adds Colla Corii Asini powder mixing, and above-mentioned fine powder adds an amount of dextrin, magnesium stearate, stevioside, mixing; with dry granulation mechanism grain; encapsulated, packing, promptly.
Embodiment 22
200 parts of 180 portions of Aloes of 150 parts of Semen Cassiaes of Radix Polygoni Multiflori
80 parts of 100 parts of Radix Ginsengs of 100 parts of Colla Corii Asini of Fructus Lycii
80 parts of 80 parts of Rhizoma Atractylodis Macrocephalaes of Fructus Aurantii Immaturus.
Colla Corii Asini is worn into fine powder (crossing 80 mesh sieves), and is standby; Radix Ginseng, Radix Polygoni Multiflori, Semen Cassiae, Aloe are adopted alcohol extracting method, 60% ethanol backwash 2 times, and each 1.5 hours, medicinal liquid filtered, reclaims ethanol, concentrates; Fructus Lycii, Fructus Aurantii Immaturus, the Rhizoma Atractylodis Macrocephalae add 8 times of water, soak 2.5 hours, decoct 2 hours, add 6 times of water again, decoct 2 hours; Merge decoction liquor, filter, be evaporated to medical material: water is about 0.8: 1; transfer alcohol to 55%, Cryoprecipitation 12 hours filters; concentrating under reduced pressure becomes extractum and alcohol reflux extractum to merge; drying adds Colla Corii Asini powder mixing, and above-mentioned fine powder adds an amount of dextrin, magnesium stearate, stevioside, mixing; with dry granulation mechanism grain; encapsulated, packing, promptly.
Embodiment 23
200 parts of 180 portions of Aloes of 150 parts of Semen Cassiaes of Radix Polygoni Multiflori
80 parts of 100 parts of Radix Ginsengs of 100 parts of Colla Corii Asini of Fructus Lycii
20 parts of 150 parts of Rhizoma Atractylodis Macrocephalaes of Fructus Aurantii Immaturus.
Colla Corii Asini is worn into fine powder (crossing 80 mesh sieves), and is standby; Radix Ginseng, Radix Polygoni Multiflori, Semen Cassiae, Aloe are adopted alcohol extracting method, 60% ethanol backwash 2 times, and each 1.5 hours, medicinal liquid filtered, reclaims ethanol, concentrates; Fructus Lycii, Fructus Aurantii Immaturus, the Rhizoma Atractylodis Macrocephalae add 8 times of water, soak 2.5 hours, decoct 2 hours, add 6 times of water again, decoct 2 hours; Merge decoction liquor, filter, be evaporated to medical material: water is about 1: 1; transfer alcohol to 55%, Cryoprecipitation 12 hours filters; concentrating under reduced pressure becomes extractum and alcohol reflux extractum to merge; drying adds Colla Corii Asini powder mixing, and above-mentioned fine powder adds an amount of dextrin, magnesium stearate, stevioside, mixing; with dry granulation mechanism grain; encapsulated, packing, promptly.
Embodiment 24
160 parts of 150 portions of Aloes of 80 parts of Semen Cassiaes of Radix Polygoni Multiflori
50 parts of 80 parts of Radix Ginsengs of 80 parts of Colla Corii Asini of Fructus Lycii
50 parts of 120 parts of Rhizoma Atractylodis Macrocephalaes of Fructus Aurantii Immaturus.
Colla Corii Asini is worn into fine powder (crossing 80 mesh sieves), and is standby; Radix Ginseng, Radix Polygoni Multiflori, Semen Cassiae, Aloe are adopted alcohol extracting method, 60% ethanol backwash 2 times, and each 1.5 hours, medicinal liquid filtered, reclaims ethanol, concentrates; Fructus Lycii, Fructus Aurantii Immaturus, the Rhizoma Atractylodis Macrocephalae add 8 times of water, soak 2.5 hours, decoct 2 hours, add 6 times of water again, decoct 2 hours; Merge decoction liquor, filter, be evaporated to medical material: water is about 1: 1; transfer alcohol to 55%, Cryoprecipitation 12 hours filters; concentrating under reduced pressure becomes extractum and alcohol reflux extractum to merge; drying adds Colla Corii Asini powder mixing, and above-mentioned fine powder adds an amount of dextrin, magnesium stearate, stevioside, mixing; with dry granulation mechanism grain; encapsulated, packing, promptly.
Embodiment 25
160 parts of 100 portions of Aloes of 120 parts of Semen Cassiaes of Radix Polygoni Multiflori
50 parts of 80 parts of Radix Ginsengs of 80 parts of Colla Corii Asini of Fructus Lycii
50 parts of 120 parts of Rhizoma Atractylodis Macrocephalaes of Fructus Aurantii Immaturus.
Colla Corii Asini is worn into fine powder (crossing 80 mesh sieves), and is standby; Radix Ginseng, Radix Polygoni Multiflori, Semen Cassiae, Aloe are adopted alcohol extracting method, 60% ethanol backwash 2 times, and each 1.5 hours, medicinal liquid filtered, reclaims ethanol, concentrates; Fructus Lycii, Fructus Aurantii Immaturus, the Rhizoma Atractylodis Macrocephalae add 8 times of water, soak 2.5 hours, decoct 2 hours, add 6 times of water again, decoct 2 hours; Merge decoction liquor, filter, be evaporated to medical material: water is about 1: 1; transfer alcohol to 55%, Cryoprecipitation 12 hours filters; concentrating under reduced pressure becomes extractum and alcohol reflux extractum to merge; drying adds Colla Corii Asini powder mixing, and above-mentioned fine powder adds an amount of dextrin, magnesium stearate, stevioside, mixing; with dry granulation mechanism grain; encapsulated, packing, promptly.
Embodiment 26
160 parts of 150 portions of Aloes of 120 parts of Semen Cassiaes of Radix Polygoni Multiflori
50 parts of 40 parts of Radix Ginsengs of 80 parts of Colla Corii Asini of Fructus Lycii
50 parts of 120 parts of Rhizoma Atractylodis Macrocephalaes of Fructus Aurantii Immaturus.
Colla Corii Asini is worn into fine powder (crossing 80 mesh sieves), and is standby; Radix Ginseng, Radix Polygoni Multiflori, Semen Cassiae, Aloe are adopted alcohol extracting method, 60% ethanol backwash 2 times, and each 1.5 hours, medicinal liquid filtered, reclaims ethanol, concentrates; Fructus Lycii, Fructus Aurantii Immaturus, the Rhizoma Atractylodis Macrocephalae add 8 times of water, soak 2.5 hours, decoct 2 hours, add 6 times of water again, decoct 2 hours; Merge decoction liquor, filter, be evaporated to medical material: water is about 1: 1; transfer alcohol to 55%, Cryoprecipitation 12 hours filters; concentrating under reduced pressure becomes extractum and alcohol reflux extractum to merge; drying adds Colla Corii Asini powder mixing, and above-mentioned fine powder adds an amount of dextrin, magnesium stearate, stevioside, mixing; with dry granulation mechanism grain; encapsulated, packing, promptly.
Embodiment 27
160 parts of 150 portions of Aloes of 120 parts of Semen Cassiaes of Radix Polygoni Multiflori
20 parts of 80 parts of Radix Ginsengs of Fructus Lycii 80 Colla Corii Asini
50 parts of 120 parts of Rhizoma Atractylodis Macrocephalaes of Fructus Aurantii Immaturus.
Colla Corii Asini is worn into fine powder (crossing 80 mesh sieves), and is standby; Radix Ginseng, Radix Polygoni Multiflori, Semen Cassiae, Aloe are adopted alcohol extracting method, 60% ethanol backwash 2 times, and each 1.5 hours, medicinal liquid filtered, reclaims ethanol, concentrates; Fructus Lycii, Fructus Aurantii Immaturus, the Rhizoma Atractylodis Macrocephalae add 8 times of water, soak 2.5 hours, decoct 2 hours, add 6 times of water again, decoct 2 hours; Merge decoction liquor, filter, be evaporated to medical material: water is about 1: 1; transfer alcohol to 55%, Cryoprecipitation 12 hours filters; concentrating under reduced pressure becomes extractum and alcohol reflux extractum to merge; drying adds Colla Corii Asini powder mixing, and above-mentioned fine powder adds an amount of dextrin, magnesium stearate, stevioside, mixing; with dry granulation mechanism grain; encapsulated, packing, promptly.
Embodiment 28
160 parts of 150 portions of Aloes of 120 parts of Semen Cassiaes of Radix Polygoni Multiflori
50 parts of 80 parts of Radix Ginsengs of 80 parts of Colla Corii Asini of Fructus Lycii
30 parts of 120 parts of Rhizoma Atractylodis Macrocephalaes of Fructus Aurantii Immaturus
Colla Corii Asini is worn into fine powder (crossing 80 mesh sieves), and is standby; Radix Ginseng, Radix Polygoni Multiflori, Semen Cassiae, Aloe are adopted alcohol extracting method, 60% ethanol backwash 2 times, and each 1.5 hours, medicinal liquid filtered, reclaims ethanol, concentrates; Fructus Lycii, Fructus Aurantii Immaturus, the Rhizoma Atractylodis Macrocephalae add 8 times of water, soak 2.5 hours, decoct 2 hours, add 6 times of water again, decoct 2 hours; Merge decoction liquor, filter, be evaporated to medical material: water is about 1: 1; transfer alcohol to 55%, Cryoprecipitation 12 hours filters; concentrating under reduced pressure becomes extractum and alcohol reflux extractum to merge; drying adds Colla Corii Asini powder mixing, and above-mentioned fine powder adds an amount of dextrin, magnesium stearate, stevioside, mixing; with dry granulation mechanism grain; encapsulated, packing, promptly.
Embodiment 29
130 parts of 120 portions of Aloes of 100 parts of Semen Cassiaes of Radix Polygoni Multiflori
30 parts of 60 parts of Radix Ginsengs of 65 parts of Colla Corii Asini of Fructus Lycii
90 parts of the Radix Aucklandiae
The Radix Aucklandiae adds 8 times of water gagings, soaked 2 hours, and vapor distillation 5 hours, it is standby to collect volatile oil, and Colla Corii Asini is worn into fine powder (crossing 80 mesh sieves), and is standby; Radix Ginseng, Radix Polygoni Multiflori, Semen Cassiae, Aloe are adopted alcohol extracting method, 60% ethanol backwash 2 times, and each 1.5 hours, medicinal liquid filtered, reclaims ethanol, concentrates; The Fructus Lycii and the Radix Aucklandiae are carried oil back medicinal residues and are added 8 times of water, soak 2.5 hours, decoct 2 hours, add 6 times of water again, decoct 2 hours; Merge decoction liquor, filter, be evaporated to medical material: water is about 1: 1; transfer alcohol to 55%, Cryoprecipitation 12 hours filters; concentrating under reduced pressure becomes extractum and alcohol reflux extractum to merge; drying adds Colla Corii Asini powder mixing, and above-mentioned fine powder adds an amount of dextrin, magnesium stearate, stevioside, mixing; with dry granulation mechanism grain; encapsulated, packing, promptly.
Embodiment 30
130 parts of 120 portions of Aloes of 100 parts of Semen Cassiaes of Radix Polygoni Multiflori
30 parts of 60 parts of Radix Ginsengs of 65 parts of Colla Corii Asini of Fructus Lycii
30 parts of 90 parts of Rhizoma Atractylodis Macrocephalaes of the Radix Aucklandiae
The Radix Aucklandiae adds 8 times of water gagings, soaked 2 hours, and vapor distillation 5 hours, it is standby to collect volatile oil, and Colla Corii Asini is worn into fine powder (crossing 80 mesh sieves), and is standby; Radix Ginseng, Radix Polygoni Multiflori, Semen Cassiae, Aloe are adopted alcohol extracting method, 60% ethanol backwash 2 times, and each 1.5 hours, medicinal liquid filtered, reclaims ethanol, concentrates; Fructus Lycii, the Rhizoma Atractylodis Macrocephalae and the Radix Aucklandiae are carried oil back medicinal residues and are added 8 times of water, soak 2.5 hours, decoct 2 hours, add 6 times of water again, decoct 2 hours; Merge decoction liquor, filter, be evaporated to medical material: water is about 1: 1; transfer alcohol to 55%, Cryoprecipitation 12 hours filters; concentrating under reduced pressure becomes extractum and alcohol reflux extractum to merge; drying adds Colla Corii Asini powder mixing, and above-mentioned fine powder adds an amount of dextrin, magnesium stearate, stevioside, mixing; be used for legal system grain mechanism grain; encapsulated, packing, promptly.
Embodiment 31
130 parts of 120 portions of Aloes of 100 parts of Semen Cassiaes of Radix Polygoni Multiflori
30 parts of 60 parts of Radix Ginsengs of 65 parts of Colla Corii Asini of Fructus Lycii
30 parts of 120 parts of Radix Aucklandiae of Fructus Aurantii Immaturus
The Radix Aucklandiae adds 8 times of water gagings, soaked 2 hours, and vapor distillation 5 hours, it is standby to collect volatile oil, and Colla Corii Asini is worn into fine powder (crossing 80 mesh sieves), and is standby; Radix Ginseng, Radix Polygoni Multiflori, Semen Cassiae, Aloe are adopted alcohol extracting method, 60% ethanol backwash 2 times, and each 1.5 hours, medicinal liquid filtered, reclaims ethanol, concentrates; Fructus Lycii, the Rhizoma Atractylodis Macrocephalae and the Radix Aucklandiae are carried oil back medicinal residues and are added 8 times of water, soak 2.5 hours, decoct 2 hours, add 6 times of water again, decoct 2 hours; Merge decoction liquor, filter, be evaporated to medical material: water is about 1: 1; transfer alcohol to 55%, Cryoprecipitation 12 hours filters; concentrating under reduced pressure becomes extractum and alcohol reflux extractum to merge; drying adds Colla Corii Asini powder mixing, and above-mentioned fine powder adds an amount of dextrin, magnesium stearate, stevioside, mixing; with dry granulation mechanism grain; encapsulated, packing, promptly.
Embodiment 32
160 parts of 150 portions of Aloes of 120 parts of Semen Cassiaes of Radix Polygoni Multiflori
50 parts of 80 parts of Radix Ginsengs of 80 parts of Radix Angelicae Sinensis of Fructus Lycii
30 parts of 120 parts of Rhizoma Atractylodis Macrocephalaes of Fructus Aurantii Immaturus
Radix Angelicae Sinensis adds 8 times of water gagings, soaked 2 hours, and vapor distillation 5 hours, it is standby to collect volatile oil; Radix Ginseng, Radix Polygoni Multiflori, Semen Cassiae, Aloe are adopted alcohol extracting method, 60% ethanol backwash 2 times, and each 1.5 hours, medicinal liquid filtered, reclaims ethanol, concentrates; Fructus Lycii, Fructus Aurantii Immaturus, the Rhizoma Atractylodis Macrocephalae and Radix Angelicae Sinensis are carried oil back medicinal residues and are added 8 times of water, soak 2.5 hours, decoct 2 hours, add 6 times of water again, decoct 2 hours; Merge decoction liquor, filter, be evaporated to medical material: water is about 1: 1; transfer alcohol to 55%, Cryoprecipitation 12 hours filters; concentrating under reduced pressure becomes extractum and alcohol reflux extractum to merge; drying adds Colla Corii Asini powder mixing, and above-mentioned fine powder adds an amount of dextrin, magnesium stearate, stevioside, mixing; with dry granulation mechanism grain; encapsulated, packing, promptly.
Embodiment 33
160 parts of 150 portions of Aloes of 120 parts of Semen Cassiaes of Radix Et Rhizoma Rhei
50 parts of 80 parts of Radix Ginsengs of 80 parts of Colla Corii Asini of Fructus Lycii
30 parts of 120 parts of Rhizoma Atractylodis Macrocephalaes of Fructus Aurantii Immaturus
Colla Corii Asini is worn into fine powder (crossing 80 mesh sieves), and is standby; Radix Ginseng, Radix Et Rhizoma Rhei, Semen Cassiae, Aloe are adopted alcohol extracting method, 60% ethanol backwash 2 times, and each 1.5 hours, medicinal liquid filtered, reclaims ethanol, concentrates; Fructus Lycii, Fructus Aurantii Immaturus, the Rhizoma Atractylodis Macrocephalae add 8 times of water, soak 2.5 hours, decoct 2 hours, add 6 times of water again, decoct 2 hours; Merge decoction liquor, filter, be evaporated to medical material: water is about 1: 1; transfer alcohol to 55%, Cryoprecipitation 12 hours filters; concentrating under reduced pressure becomes extractum and alcohol reflux extractum to merge; drying adds Colla Corii Asini powder mixing, and above-mentioned fine powder adds an amount of dextrin, magnesium stearate, stevioside, mixing; with dry granulation mechanism grain; encapsulated, packing, promptly
Embodiment 34
160 parts of 150 portions of Aloes of 120 parts of Radix Et Rhizoma Rhei of Radix Polygoni Multiflori
50 parts of 80 parts of Radix Ginsengs of 80 parts of Colla Corii Asini of Fructus Lycii
30 parts of 120 parts of Rhizoma Atractylodis Macrocephalaes of Fructus Aurantii Immaturus
Colla Corii Asini is worn into fine powder (crossing 80 mesh sieves), and is standby; Radix Ginseng, Radix Polygoni Multiflori, Radix Et Rhizoma Rhei, Aloe are adopted alcohol extracting method, 60% ethanol backwash 2 times, and each 1.5 hours, medicinal liquid filtered, reclaims ethanol, concentrates; Fructus Lycii, Fructus Aurantii Immaturus, the Rhizoma Atractylodis Macrocephalae add 8 times of water, soak 2.5 hours, decoct 2 hours, add 6 times of water again, decoct 2 hours; Merge decoction liquor, filter, be evaporated to medical material: water is about 1: 1; transfer alcohol to 55%, Cryoprecipitation 12 hours filters; concentrating under reduced pressure becomes extractum and alcohol reflux extractum to merge; drying adds Colla Corii Asini powder mixing, and above-mentioned fine powder adds an amount of dextrin, magnesium stearate, stevioside, mixing; with dry granulation mechanism grain; encapsulated, packing, promptly.
Embodiment 35
160 parts of 150 parts of Radix Et Rhizoma Rhei of 120 parts of Semen Cassiaes of Radix Polygoni Multiflori
50 parts of 80 parts of Radix Ginsengs of 80 parts of Colla Corii Asini of Fructus Lycii
30 parts of 120 parts of Rhizoma Atractylodis Macrocephalaes of Fructus Aurantii Immaturus
Colla Corii Asini is worn into fine powder (crossing 80 mesh sieves), and is standby; Radix Ginseng, Radix Polygoni Multiflori, Semen Cassiae, Radix Et Rhizoma Rhei adopt alcohol extracting method, 60% ethanol backwash 2 times, and each 1.5 hours, medicinal liquid filtered, reclaims ethanol, concentrates; Fructus Lycii, Fructus Aurantii Immaturus, the Rhizoma Atractylodis Macrocephalae add 8 times of water, soak 2.5 hours, decoct 2 hours, add 6 times of water again, decoct 2 hours; Merge decoction liquor, filter, be evaporated to medical material: water is about 1: 1; transfer alcohol to 55%, Cryoprecipitation 12 hours filters; concentrating under reduced pressure becomes extractum and alcohol reflux extractum to merge; drying adds Colla Corii Asini powder mixing, and above-mentioned fine powder adds an amount of dextrin, magnesium stearate, stevioside, mixing; with dry granulation mechanism grain; encapsulated, packing, promptly.
Embodiment 36
160 parts of 30 portions of Aloes of 120 parts of Rhizoma Atractylodis Macrocephalaes of Radix Et Rhizoma Rhei
50 parts of 80 parts of Radix Ginsengs of 80 parts of Colla Corii Asini of Fructus Lycii
120 parts of Fructus Aurantii Immaturuss
Colla Corii Asini is worn into fine powder (crossing 80 mesh sieves), and is standby; Radix Ginseng, Radix Et Rhizoma Rhei, Aloe are adopted alcohol extracting method, 60% ethanol backwash 2 times, and each 1.5 hours, medicinal liquid filtered, reclaims ethanol, concentrates; Fructus Lycii, Fructus Aurantii Immaturus, the Rhizoma Atractylodis Macrocephalae add 8 times of water, soak 2.5 hours, decoct 2 hours, add 6 times of water again, decoct 2 hours; Merge decoction liquor, filter, be evaporated to medical material: water is about 1: 1; transfer alcohol to 55%, Cryoprecipitation 12 hours filters; concentrating under reduced pressure becomes extractum and alcohol reflux extractum to merge; drying adds Colla Corii Asini powder mixing, and above-mentioned fine powder adds an amount of dextrin, magnesium stearate, stevioside, mixing; with dry granulation mechanism grain; encapsulated, packing, promptly.
Embodiment 37
30 parts of 150 parts of Rhizoma Atractylodis Macrocephalaes of 120 parts of Radix Et Rhizoma Rhei of Radix Polygoni Multiflori
50 parts of 80 parts of Radix Ginsengs of 80 parts of Colla Corii Asini of Fructus Lycii
120 parts of Fructus Aurantii Immaturuss
Colla Corii Asini is worn into fine powder (crossing 80 mesh sieves), and is standby; Radix Ginseng, Radix Polygoni Multiflori, Radix Et Rhizoma Rhei adopt alcohol extracting method, 60% ethanol backwash 2 times, and each 1.5 hours, medicinal liquid filtered, reclaims ethanol, concentrates; Fructus Lycii, Fructus Aurantii Immaturus, the Rhizoma Atractylodis Macrocephalae add 8 times of water, soak 2.5 hours, decoct 2 hours, add 6 times of water again, decoct 2 hours; Merge decoction liquor, filter, be evaporated to medical material: water is about 1: 1; transfer alcohol to 55%, Cryoprecipitation 12 hours filters; concentrating under reduced pressure becomes extractum and alcohol reflux extractum to merge; drying adds Colla Corii Asini powder mixing, and above-mentioned fine powder adds an amount of dextrin, magnesium stearate, stevioside, mixing; with dry granulation mechanism grain; encapsulated, packing, promptly.
Embodiment 38
30 parts of 150 parts of Rhizoma Atractylodis Macrocephalaes of 120 parts of Semen Cassiaes of Radix Et Rhizoma Rhei
50 parts of 80 parts of Radix Ginsengs of 80 parts of Colla Corii Asini of Fructus Lycii
120 parts of Fructus Aurantii Immaturuss
Colla Corii Asini is worn into fine powder (crossing 80 mesh sieves), and is standby; Radix Ginseng, Semen Cassiae, Radix Et Rhizoma Rhei adopt alcohol extracting method, 60% ethanol backwash 2 times, and each 1.5 hours, medicinal liquid filtered, reclaims ethanol, concentrates; Fructus Lycii, Fructus Aurantii Immaturus, the Rhizoma Atractylodis Macrocephalae add 8 times of water, soak 2.5 hours, decoct 2 hours, add 6 times of water again, decoct 2 hours; Merge decoction liquor, filter, be evaporated to medical material: water is about 1: 1; transfer alcohol to 55%, Cryoprecipitation 12 hours filters; concentrating under reduced pressure becomes extractum and alcohol reflux extractum to merge; drying adds Colla Corii Asini powder mixing, and above-mentioned fine powder adds an amount of dextrin, magnesium stearate, stevioside, mixing; with dry granulation mechanism grain; encapsulated, packing, promptly.
Embodiment 39
30 parts of 120 parts of Rhizoma Atractylodis Macrocephalaes of 120 parts of Fructus Aurantii Immaturuss of Radix Et Rhizoma Rhei
50 parts of 80 parts of Radix Ginsengs of 80 parts of Colla Corii Asini of Fructus Lycii
Colla Corii Asini is worn into fine powder (crossing 80 mesh sieves), and is standby; Radix Ginseng, Semen Cassiae, Radix Et Rhizoma Rhei adopt alcohol extracting method, 60% ethanol backwash 2 times, and each 1.5 hours, medicinal liquid filtered, reclaims ethanol, concentrates; Fructus Lycii, Fructus Aurantii Immaturus, the Rhizoma Atractylodis Macrocephalae add 8 times of water, soak 2.5 hours, decoct 2 hours, add 6 times of water again, decoct 2 hours; Merge decoction liquor, filter, be evaporated to medical material: water is about 1: 1; transfer alcohol to 55%, Cryoprecipitation 12 hours filters; concentrating under reduced pressure becomes extractum and alcohol reflux extractum to merge; drying adds Colla Corii Asini powder mixing, and above-mentioned fine powder adds an amount of dextrin, magnesium stearate, stevioside, mixing; with dry granulation mechanism grain; encapsulated, packing, promptly.
Claims (10)
1, a kind of Chinese medicine composition with catharsis and toxin expelling, fat reducing and weight reducing function is characterized in that it is to be made by the raw material that comprises following weight parts:
Radix Polygoni Multiflori 25-400 part Semen Cassiae 30-500 part Aloe 30-600 part
Fructus Lycii 30-150 part Colla Corii Asini 30-150 part Radix Ginseng 20-100 part.
2, compositions according to claim 1 is characterized in that it also comprises:
Fructus Aurantii Immaturus 50-200 part Rhizoma Atractylodis Macrocephalae 20-100 part.
3, compositions according to claim 2 is characterized in that said raw material weight ratio is:
Radix Polygoni Multiflori 60-150 part Semen Cassiae 80-180 part Aloe 100-200 part
Fructus Lycii 30-100 part Colla Corii Asini 30-100 part Radix Ginseng 20-80 part
Fructus Aurantii Immaturus 80-150 part Rhizoma Atractylodis Macrocephalae 20-80 part.
4, compositions according to claim 3 is characterized in that said raw material weight ratio is:
Radix Polygoni Multiflori 80-120 part Semen Cassiae 100-150 part Aloe 120-160 part
Fructus Lycii 50-80 part Colla Corii Asini 40-80 part Radix Ginseng 20-50 part
Fructus Aurantii Immaturus 80-120 part Rhizoma Atractylodis Macrocephalae 30-50 part.
5, Chinese medicine composition according to claim 5 is characterized in that wherein Fructus Aurantii Immaturus, the Rhizoma Atractylodis Macrocephalae can be used in the Radix Aucklandiae, the Pericarpium Citri Reticulatae simply or two flavors replace, and Colla Corii Asini can replace with Radix Angelicae Sinensis, among Radix Polygoni Multiflori, Semen Cassiae, the Aloe simply or multi-flavor can replace with Radix Et Rhizoma Rhei.
6,, it is characterized in that the made dosage form of this Chinese medicine composition is any receptible dosage form clinically according to the described Chinese medicine composition of claim 1-5.
7,, it is characterized in that the said dosage form of this medicine is capsule, tablet, granule according to the described Chinese medicine composition of claim 6.
8, according to the described preparation of claim 7, it is characterized in that its every gram contains in the thing admittedly contains: the ginsenoside Rg
1With ginsenoside Re's total amount 0.08mg-1.5mg, emodin 1mg-100mg.
9,, it is characterized in that its effective constituent determination method is according to the described preparation of claim 8:
(1) ginsenoside's assay method
The preparation of reference substance solution: precision takes by weighing the ginsenoside Rg
1, each is an amount of for the Re reference substance, add methanol and make respectively among every 1ml and contain the ginsenoside Rg
10.5mg, the solution of ginsenoside Re 0.4mg, product solution in contrast;
The preparation of need testing solution: get this product and pulverize, get about 1.0g, the accurate title, decide, and is dissolved in water, and filters, and with water-saturated n-butanol extraction 4 times, extract washes twice with caustic lye of soda, and n-butyl alcohol is put evaporate to dryness in the evaporating dish, and dissolve with methanol filters, promptly;
Chromatographic condition: with octadecylsilane chemically bonded silica is filler;
Volume ratio is that 99: 400 acetonitrile-0.05% phosphoric acid solution is a mobile phase;
Detect wavelength 203nm;
Algoscopy: accurate respectively reference substance solution and each 10 μ l of need testing solution of drawing, inject hplc determination.
(2) emodin assay method
The preparation of reference substance solution: precision takes by weighing emodin reference substance 5mg, puts in the 50ml measuring bottle, with dissolve with methanol and dilution, measures 1ml, puts in the 25ml measuring bottle, adds methanol to scale, makes the solution that contains emodin 4 μ g among every 1ml, in contrast product solution;
The preparation of need testing solution: get this product and pulverize, get about 1.0g, the accurate title, decide, be dissolved in water, filter evaporate to dryness, add dissolve with methanol, filter, fling to methanol, add 2.5mol/L sulfuric acid solution 10ml, supersound process 5 minutes adds chloroform 10ml again, reflux 1 hour, cooling is in the dislocation separatory funnel, use the minimum of chloroform washing container, incorporate in the separatory funnel, divide and get chloroform layer, sour water chloroform extraction, the combined chloroform layer, with anhydrous sodium sulfate dehydration, chloroform solution is flung to, and the residue precision adds methanol 10ml, dissolving, promptly.
Chromatographic condition: with octadecylsilane chemically bonded silica is filler;
Volume ratio is that 85: 15 methanol-0.1% phosphoric acid solution is a mobile phase;
Detect wavelength 254nm;
Algoscopy: accurate respectively reference substance solution and each 5 μ l of need testing solution of drawing, inject hplc determination.
10, according to the described Chinese medicine composition of claim 1-8, it is characterized in that it prepares according to following method: Colla Corii Asini is worn into fine powder (crossing 80 mesh sieves) or molten, and is standby; Radix Ginseng, Radix Polygoni Multiflori, Semen Cassiae, Aloe are adopted alcohol extracting method, 40%-80% ethanol backwash 1-3 time, and each 1-3 hour, medicinal liquid filtered, reclaims ethanol, concentrates; Fructus Lycii, Fructus Aurantii Immaturus, the Rhizoma Atractylodis Macrocephalae add 5-10 times of water, soak 0.5-3 hour, decoct 1-3 hour, add 5-10 times of water again, decoct 1-3 hour; Merge decoction liquor, filter, be evaporated to medical material: water is about 1: 1-3: 1, transfer alcohol to 40%-85%, Cryoprecipitation 12-48 hour, filter, concentrating under reduced pressure becomes extractum and alcohol reflux extractum to merge or is dry, solution and right amount of auxiliary materials are made clinical receptible various dosage forms with the conventional formulation method after adding Colla Corii Asini powder or the molten, promptly.
Priority Applications (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNB200410073958XA CN100453105C (en) | 2004-09-17 | 2004-09-17 | Composition with catharsis and toxin expelling, fat reducing and weight reducing function and preparing method |
| HK06108624.1A HK1088236A1 (en) | 2004-09-17 | 2006-08-03 | A composition for promoting defecation to expelling toxin and losing weight and reducing blood fat and the preparation method thereof |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNB200410073958XA CN100453105C (en) | 2004-09-17 | 2004-09-17 | Composition with catharsis and toxin expelling, fat reducing and weight reducing function and preparing method |
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| CN1748765A true CN1748765A (en) | 2006-03-22 |
| CN100453105C CN100453105C (en) | 2009-01-21 |
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| HK (1) | HK1088236A1 (en) |
Cited By (25)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101537160B (en) * | 2009-04-29 | 2011-01-05 | 田均 | Health product for toxicant elimination and beauty maintenance |
| CN101537108B (en) * | 2009-04-08 | 2011-12-21 | 杨泗兴 | Composition with functions of defaecation and detoxification, skin care and freckle dispelling, and preparation method thereof |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN111298005A (en) * | 2018-11-23 | 2020-06-19 | 鲁南制药集团股份有限公司 | Use of 'Jiehui Tongbiang' capsule and its preparing process |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1335142A (en) * | 2000-07-26 | 2002-02-13 | 雷学军 | Weight reducing water containing natural medicinal component and its prepn |
| CN1159047C (en) * | 2002-01-18 | 2004-07-28 | 北京大学 | Active components of Chinese-medicinal medicine with weight-losing and hypolipemic actions and its relative medicine |
-
2004
- 2004-09-17 CN CNB200410073958XA patent/CN100453105C/en not_active Expired - Lifetime
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Cited By (35)
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| CN101537108B (en) * | 2009-04-08 | 2011-12-21 | 杨泗兴 | Composition with functions of defaecation and detoxification, skin care and freckle dispelling, and preparation method thereof |
| CN101537160B (en) * | 2009-04-29 | 2011-01-05 | 田均 | Health product for toxicant elimination and beauty maintenance |
| CN102526436A (en) * | 2012-02-16 | 2012-07-04 | 朱剑萍 | Slimming capsule and preparation method and application thereof |
| CN102641364A (en) * | 2012-05-08 | 2012-08-22 | 鲍旭刚 | Drug for treating constipation and preparation method thereof |
| CN103784819A (en) * | 2013-05-31 | 2014-05-14 | 吕汉 | Chinese medicinal weight-reducing prescription |
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| CN106124685B (en) * | 2016-06-10 | 2017-05-10 | 鲁南厚普制药有限公司 | Quality detection method of fallopia multiflora (thunb.) harald-aloe constipation relieving capsules |
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| CN111297974A (en) * | 2018-11-23 | 2020-06-19 | 鲁南制药集团股份有限公司 | Application of traditional Chinese medicine composition in preparation of medicine for treating food stagnation |
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| CN113304135A (en) * | 2020-02-27 | 2021-08-27 | 鲁南制药集团股份有限公司 | Composition for treating diabetic gastroparesis and application thereof |
| CN113304135B (en) * | 2020-02-27 | 2022-11-04 | 鲁南制药集团股份有限公司 | Composition for treating diabetic gastroparesis and application thereof |
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| CN111249381A (en) * | 2020-03-28 | 2020-06-09 | 鲁南制药集团股份有限公司 | Application of composition in preparation of medicine for preventing and treating constipation |
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| CN111568988A (en) * | 2020-06-24 | 2020-08-25 | 鲁南制药集团股份有限公司 | Preparation method of fleece-flower root and aloe cathartic preparation |
| CN113995801A (en) * | 2020-07-28 | 2022-02-01 | 山东新时代药业有限公司 | Medical application of aloe capsule for relaxing bowels |
| CN113995801B (en) * | 2020-07-28 | 2024-06-07 | 山东新时代药业有限公司 | Medical application of polygonum multiflorum and aloe cathartic capsules |
| CN114432390A (en) * | 2020-10-20 | 2022-05-06 | 鲁南制药集团股份有限公司 | Application of traditional Chinese medicine composition in treatment of fatty liver |
| CN113577206A (en) * | 2021-07-22 | 2021-11-02 | 滨州市人民医院 | Preparation method of ginsenoside slimming agent |
Also Published As
| Publication number | Publication date |
|---|---|
| CN100453105C (en) | 2009-01-21 |
| HK1088236A1 (en) | 2006-11-03 |
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