CN115605576A - 生物样本图像采集装置及基因测序仪 - Google Patents

生物样本图像采集装置及基因测序仪 Download PDF

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Publication number
CN115605576A
CN115605576A CN202080090989.3A CN202080090989A CN115605576A CN 115605576 A CN115605576 A CN 115605576A CN 202080090989 A CN202080090989 A CN 202080090989A CN 115605576 A CN115605576 A CN 115605576A
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biological sample
movable
movable platforms
platforms
objective lenses
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王忠海
邢楚填
蒋健君
姜鹤鸣
张永卫
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BGI Shenzhen Co Ltd
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BGI Shenzhen Co Ltd
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    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/64—Fluorescence; Phosphorescence
    • G01N21/645—Specially adapted constructive features of fluorimeters
    • G01N21/6456—Spatial resolved fluorescence measurements; Imaging
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/64—Fluorescence; Phosphorescence
    • G01N21/6428—Measuring fluorescence of fluorescent products of reactions or of fluorochrome labelled reactive substances, e.g. measuring quenching effects, using measuring "optrodes"
    • G—PHYSICS
    • G02—OPTICS
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    • C12M41/00—Means for regulation, monitoring, measurement or control, e.g. flow regulation
    • C12M41/30—Means for regulation, monitoring, measurement or control, e.g. flow regulation of concentration
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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6869—Methods for sequencing
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    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
    • G01N15/10—Investigating individual particles
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    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/64—Fluorescence; Phosphorescence
    • G01N21/645—Specially adapted constructive features of fluorimeters
    • G01N2021/6463—Optics
    • G01N2021/6478—Special lenses
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/64—Fluorescence; Phosphorescence
    • G01N21/645—Specially adapted constructive features of fluorimeters
    • G01N21/6452—Individual samples arranged in a regular 2D-array, e.g. multiwell plates
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/64—Fluorescence; Phosphorescence
    • G01N21/645—Specially adapted constructive features of fluorimeters
    • G01N21/6456—Spatial resolved fluorescence measurements; Imaging
    • G01N21/6458—Fluorescence microscopy
    • G—PHYSICS
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    • G01N2201/00—Features of devices classified in G01N21/00
    • G01N2201/06—Illumination; Optics
    • G01N2201/061—Sources
    • G01N2201/06113—Coherent sources; lasers
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2201/00—Features of devices classified in G01N21/00
    • G01N2201/06—Illumination; Optics
    • G01N2201/063—Illuminating optical parts
    • G01N2201/0636—Reflectors
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2201/00—Features of devices classified in G01N21/00
    • G01N2201/06—Illumination; Optics
    • G01N2201/063—Illuminating optical parts
    • G01N2201/0638—Refractive parts

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  • Microscoopes, Condenser (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)

Abstract

一种生物样本图像采集装置(100)包括支撑件(30)及光学成像组件(50)，所述生物样本图像采集装置(100)还包括：多个活动平台(40)，活动地连接于所述支撑件(30)上，用于放置生物样本(20)并带动所述生物样本(20)运动，所述多个活动平台(40)阵列排布于所述支撑件(30)上，所述多个活动平台(40)可相对支撑件(30)运动并在运动时作用于所述支撑件(30)的作用力可相互抵消，以避免活动平台(40)运动带给所述支撑件(30)和所述生物样本(20)震动，所述光学成像组件(50)在所述多个活动平台(40)相对所述阵列中心同向同速运动时采集所述活动平台(40)上的生物样本(20)的图像。本申请还提供了一种包括上述生物样本图像采集装置(100)的基因测序仪。

Description

PCT国内申请，说明书已公开。

Claims (10)

  1. PCT国内申请，权利要求书已公开。
CN202080090989.3A 2020-06-10 2020-06-10 生物样本图像采集装置及基因测序仪 Pending CN115605576A (zh)

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Application Number Priority Date Filing Date Title
PCT/CN2020/095446 WO2021248380A1 (zh) 2020-06-10 2020-06-10 生物样本图像采集装置及基因测序仪

Publications (1)

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CN115605576A true CN115605576A (zh) 2023-01-13

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US (1) US20230113336A1 (zh)
EP (1) EP4166642A4 (zh)
JP (1) JP7422251B2 (zh)
CN (1) CN115605576A (zh)
WO (1) WO2021248380A1 (zh)

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* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS6235212A (ja) * 1985-08-09 1987-02-16 Nippon Kogaku Kk <Nikon> 観察装置
JPH0541194A (ja) * 1991-08-02 1993-02-19 Sumitomo Electric Ind Ltd 観察装置
JPH0990233A (ja) * 1995-09-26 1997-04-04 Sony Corp 顕微鏡
EP0951054B1 (en) * 1996-11-28 2008-08-13 Nikon Corporation Aligner and method for exposure
TW448487B (en) * 1997-11-22 2001-08-01 Nippon Kogaku Kk Exposure apparatus, exposure method and manufacturing method of device
JP4146952B2 (ja) * 1999-01-11 2008-09-10 キヤノン株式会社 露光装置およびデバイス製造方法
JP2005032812A (ja) 2003-07-08 2005-02-03 Nikon Corp ステージ装置及び露光装置
JP2006085235A (ja) 2004-09-14 2006-03-30 Agilent Technol Inc 移動型操作装置および移動型操作装置を制御するための方法
US20060110764A1 (en) * 2004-10-25 2006-05-25 Tom Tang Large-scale parallelized DNA sequencing
US20170022558A1 (en) * 2007-10-30 2017-01-26 Complete Genomics, Inc. Integrated system for nucleic acid sequence and analysis
CN201097108Y (zh) * 2007-11-14 2008-08-06 上海微电子装备有限公司 平衡减振精密定位装置
JP2010276831A (ja) 2009-05-28 2010-12-09 Nikon Corp 顕微鏡システム
JP4954321B2 (ja) 2010-08-18 2012-06-13 キヤノン株式会社 顕微鏡
CN105861293B (zh) * 2016-04-06 2017-11-07 深圳市瀚海基因生物科技有限公司 单分子基因测序仪
NL2018855B1 (en) * 2017-05-05 2018-11-14 Illumina Inc Laser line illuminator for high throughput sequencing
CN110487795B (zh) * 2019-10-21 2020-02-07 湖南莱博赛医用机器人有限公司 具有两个载物台的细胞分析设备及控制方法

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WO2021248380A1 (zh) 2021-12-16
EP4166642A4 (en) 2024-03-13
JP7422251B2 (ja) 2024-01-25
EP4166642A1 (en) 2023-04-19
JP2023530641A (ja) 2023-07-19
US20230113336A1 (en) 2023-04-13

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