CN115591463A - Food toad worm liposome preparation facilities - Google Patents
Food toad worm liposome preparation facilities Download PDFInfo
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- CN115591463A CN115591463A CN202211353348.XA CN202211353348A CN115591463A CN 115591463 A CN115591463 A CN 115591463A CN 202211353348 A CN202211353348 A CN 202211353348A CN 115591463 A CN115591463 A CN 115591463A
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- 239000002502 liposome Substances 0.000 title claims abstract description 37
- 238000002360 preparation method Methods 0.000 title claims abstract description 16
- 235000013305 food Nutrition 0.000 title description 2
- 238000004108 freeze drying Methods 0.000 claims abstract description 40
- 238000003825 pressing Methods 0.000 claims abstract description 19
- 238000001914 filtration Methods 0.000 claims abstract description 16
- 238000005192 partition Methods 0.000 claims description 33
- 238000003756 stirring Methods 0.000 claims description 25
- 238000007789 sealing Methods 0.000 claims description 19
- 238000010009 beating Methods 0.000 claims description 16
- 238000010298 pulverizing process Methods 0.000 claims description 15
- 241001233242 Lontra Species 0.000 claims description 9
- 230000000149 penetrating effect Effects 0.000 claims description 7
- 239000003088 amphibian venom Substances 0.000 claims 1
- 239000002002 slurry Substances 0.000 abstract description 27
- 239000000725 suspension Substances 0.000 abstract description 10
- 239000002245 particle Substances 0.000 abstract description 5
- 238000000034 method Methods 0.000 abstract description 4
- 230000008569 process Effects 0.000 abstract description 4
- 230000007246 mechanism Effects 0.000 abstract description 2
- 238000004537 pulping Methods 0.000 description 13
- 206010073071 hepatocellular carcinoma Diseases 0.000 description 10
- 231100000844 hepatocellular carcinoma Toxicity 0.000 description 10
- 241000238631 Hexapoda Species 0.000 description 7
- 239000007788 liquid Substances 0.000 description 6
- 230000033001 locomotion Effects 0.000 description 6
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- MLDQJTXFUGDVEO-UHFFFAOYSA-N BAY-43-9006 Chemical compound C1=NC(C(=O)NC)=CC(OC=2C=CC(NC(=O)NC=3C=C(C(Cl)=CC=3)C(F)(F)F)=CC=2)=C1 MLDQJTXFUGDVEO-UHFFFAOYSA-N 0.000 description 5
- 239000005511 L01XE05 - Sorafenib Substances 0.000 description 5
- 201000007270 liver cancer Diseases 0.000 description 5
- 239000002994 raw material Substances 0.000 description 5
- 229960003787 sorafenib Drugs 0.000 description 5
- GVJHHUAWPYXKBD-UHFFFAOYSA-N (±)-α-Tocopherol Chemical compound OC1=C(C)C(C)=C2OC(CCCC(C)CCCC(C)CCCC(C)C)(C)CCC2=C1C GVJHHUAWPYXKBD-UHFFFAOYSA-N 0.000 description 4
- 230000008901 benefit Effects 0.000 description 4
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Images
Classifications
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
- B01F33/00—Other mixers; Mixing plants; Combinations of mixers
- B01F33/80—Mixing plants; Combinations of mixers
- B01F33/83—Mixing plants specially adapted for mixing in combination with disintegrating operations
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D33/00—Filters with filtering elements which move during the filtering operation
- B01D33/01—Filters with filtering elements which move during the filtering operation with translationally moving filtering elements, e.g. pistons
- B01D33/015—Filters with filtering elements which move during the filtering operation with translationally moving filtering elements, e.g. pistons with flat filtering elements
- B01D33/0158—Filters with filtering elements which move during the filtering operation with translationally moving filtering elements, e.g. pistons with flat filtering elements self-supporting
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D33/00—Filters with filtering elements which move during the filtering operation
- B01D33/35—Filters with filtering elements which move during the filtering operation with multiple filtering elements characterised by their mutual disposition
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
- B01F23/00—Mixing according to the phases to be mixed, e.g. dispersing or emulsifying
- B01F23/80—After-treatment of the mixture
- B01F23/804—Drying the mixture
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
- B01F35/00—Accessories for mixers; Auxiliary operations or auxiliary devices; Parts or details of general application
- B01F35/75—Discharge mechanisms
- B01F35/754—Discharge mechanisms characterised by the means for discharging the components from the mixer
- B01F35/75455—Discharge mechanisms characterised by the means for discharging the components from the mixer using a rotary discharge means, e.g. a screw beneath the receptacle
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
- B01F2101/00—Mixing characterised by the nature of the mixed materials or by the application field
- B01F2101/22—Mixing of ingredients for pharmaceutical or medical compositions
Landscapes
- Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Apparatus Associated With Microorganisms And Enzymes (AREA)
- Crushing And Grinding (AREA)
Abstract
The invention provides a toad eating liposome preparation device, which solves the problems of complicated operation process, more using tools and longer time consumption caused by manual operation during toad eating liposome preparation. Including the urceolus, the top surface middle part of urceolus runs through and fixed mounting has bottom open-ended crushing barrel, installs reducing mechanism in the crushing barrel, and the coaxial fixed mounting in inside of urceolus has the baffle that is located the crushing barrel below, and the internally mounted of urceolus has the filtration pressure device that is located between crushing barrel and the baffle, and freeze-drying device is installed to the bottom in the urceolus. The smashing device can thoroughly smash and pulp toad and cod roes which are placed in the smashing cylinder, the filtering and pressing device can fully filter the slurry, and the slurry can repeatedly pass through the filtering and pressing screen plate to obtain liposome suspension with small and uniform particle size; can carry out the freeze-drying to the inside liposome of freeze-drying inner tube through the freeze-drying pipe to smash the liposome after with the freeze-drying through a plurality of poles of smashing and be the likepowder back, get rid of from going out the feed cylinder.
Description
Technical Field
The invention relates to the technical field of toad feeding, in particular to a preparation device of toad feeding liposome.
Background
Primary liver cancer (primary liver cancer) is the fifth most common malignant tumor in the world, and the fourth of the causes of tumor-related death is about 84 ten thousand new cases each year, wherein hepatocellular carcinoma (HCC) is the histologic type (accounting for 75% -85%) and has the characteristics of high invasiveness and high mortality, the early liver cancer is mostly resected by surgery, but the recurrence rate of HCC is still as high as 70% in 5 years after the resection of liver cancer, most of the patients recur within 2 years after the surgery, unresectable hepatocellular carcinoma (HCC) patients usually receive the multi-kinase inhibitor sorafenib or mavatinib, however, the drug resistance and adverse reaction limit the survival benefit of the patients, in recent years, the immune therapy represented by Immune Checkpoint Inhibitors (ICIs) has been greatly progressed, while the heterogeneity of HCC biological behaviors causes only 25% of the patients to generate lasting therapeutic response, although other therapeutic modalities such as ablation therapy, transcatheter arterial embolization (TACE) also have been greatly progressed, but the survival rate of the HCC patients has been only 18% recurrences.
Sorafenib is a first-line medicine for advanced HCC, and can also treat hepatocellular carcinoma by inhibiting systemXc-to further cause GSH exhaustion to induce iron death, but only a part of liver cancer patients can benefit from the drug resistance, and as many fat-soluble active ingredients of the drugs are difficult to dissolve in water, the bioavailability is low, the effective blood concentration maintenance time is short, toxic and side effects are large, and a liposome drug delivery system has the advantages of slow release, targeting property and the like, and the good drug delivery effect is widely concerned by people.
At present, researches show that toad eating liposome prepared by taking costustoot, hawk, toad, cod roe and the like as main raw materials is combined with sorafenib to be used, so that the curative effect of sorafenib can be effectively improved, the drug resistance of hepatocellular carcinoma to sorafenib is improved, the recurrence rate is reduced, for the preparation of the toad eating liposome, firstly, the toad eating liposome and the cod roe are uniformly pulped to form slurry, then, the costustoot, hawk tea and the like are ground, sieved and extracted, are uniformly mixed with the slurry and then are sieved, and finally, the powder is freeze-dried.
Therefore, the invention provides a toad feeding liposome preparation device to solve the problems.
Disclosure of Invention
In order to overcome the defects of the prior art, the invention provides the toad-eating liposome preparation device, which effectively solves the problems of complicated operation process, more using tools and longer time consumption caused by manual operation during toad-eating liposome preparation.
A toad eating liposome preparation device comprises an outer cylinder, wherein a discharge cylinder is fixedly mounted at the bottom of the outer cylinder, a crushing cylinder which is positioned in the outer cylinder and is provided with an opening at the bottom is fixedly mounted in the middle of the top surface of the outer cylinder in a penetrating manner, a crushing device is mounted in the crushing cylinder, a partition plate which is positioned below the crushing cylinder is coaxially and fixedly mounted in the outer cylinder, a filter-pressing device which is positioned between the crushing cylinder and the partition plate is mounted in the outer cylinder, and a freeze-drying device is mounted at the bottom in the outer cylinder;
reducing mechanism, including running through the hob at reducing cylinder top surface middle part, it has two reciprocal helicla flutes that head and the tail both ends are linked together to open on the surface of hob, the top fixed mounting of reducing cylinder establishes the scroll cover in the hob outside, be fixed with the reciprocal round pin that is located reciprocal helicla flute on the medial surface of scroll cover, the coaxial fixed mounting in bottom of reducing cylinder medial surface has the top to open the direction ring that has the inclined plane to the axle center slope, the bottom fixed mounting of direction ring has crushing otter board, the bottom fixedly connected with of hob is located the reducing cylinder inside and with the sealed sliding fit's of medial surface of direction ring tapered plate, it has a plurality of crushing tanks, every to run through between the bottom surface of tapered plate and the top surface, every equal slidable mounting has crushing plate, every from top to bottom of crushing plate has crushing wheel, every the bottom of crushing plate all rotates the bottom of crushing wheel, every the bottom surface of tapered plate all opens the race that corresponds with the position of crushing tank, every all be connected with crushing extension spring between the top of crushing plate and the top surface of tapered plate, it has a plurality of beating holes to run through between the bottom surface of tapered plate and the top surface of tapered plate, and every beating rod is located the beating hole and the guide rod is all installs the guide plug is connected with the pulping plug on the beating plug of every beating, the beating rod outside the crushing spring is all install the beating.
Preferably, the top of the screw rod is coaxially and fixedly connected with a crushing gear, the top of the crushing barrel is fixedly provided with a crushing motor, and a long gear meshed with the crushing gear is coaxially and fixedly arranged on a rotating shaft of the crushing motor.
Preferably, the guide ring is provided with two cylinder grooves on the ground, the two cylinder grooves are fixedly provided with crushing cylinders, telescopic shafts of the two crushing cylinders are fixedly connected with the crushing sealing disc, the top surface of the crushing sealing disc is provided with a release plate groove with the same diameter as that of the crushing net plate, the release plate groove is internally provided with a release plate in a coaxial sliding manner, a release spring is fixedly connected between the release plate and the release plate groove, and the top surface of the release plate is provided with a plurality of radial release grooves penetrating through the outer side surface of the release plate.
Preferably, filter and press the device, include and run through the filter pressure bar of smashing otter board and smashing sealed dish with the coaxial fixed connection in bottom and the bottom of tapered plate, open at the bottom surface middle part of filter pressure bar has flexible groove, flexible inslot coaxial slidable mounting has the (mixing) shaft, flexible inslot fixed mounting have with (mixing) shaft fixed connection's stirring spring, fixed mounting has a plurality of puddlers of laminating with the top surface of baffle, every on the bottom lateral surface of puddler the equal a plurality of stirring teeth of fixedly connected with in top of puddler, fixed mounting has a plurality of fan-shaped filter pressure frames that set up with a plurality of puddlers are crisscross, every on the lateral surface of filter pressure bar bottom fan-shaped filter pressure frame's inside fixed mounting has filter pressure otter board.
Preferably, four long grooves penetrate between the top surface and the bottom surface of the partition plate, a cross plate located below the partition plate is installed in the outer barrel in a vertically sliding mode, and a sealing plug matched with the four long grooves is fixedly installed at the top of the cross plate.
Preferably, the middle part of the cross plate penetrates through and is fixedly provided with a partition plate cylinder, and a telescopic shaft of the partition plate cylinder is fixedly connected with the bottom of the partition plate.
Preferably, the freeze-drying device comprises a freeze-drying inner cylinder fixedly mounted at the bottom end in the outer cylinder, and a freeze-drying pipe is mounted between the inner side surface of the outer cylinder and the outer side surface of the freeze-drying inner cylinder.
Preferably, the top that goes out the feed cylinder upwards runs through the freeze-drying inner tube, and it has the discharge gate to open on its bottom closed and side, the bottom fixed mounting that goes out the feed cylinder smashes the motor, smash the coaxial fixed mounting in pivot of motor and have the ejection of compact auger that is located the feed cylinder inside, the coaxial fixedly connected with in top of ejection of compact auger is located the freeze-drying inner tube smash the axle, smash a plurality of poles of smashing of fixedly connected with, every on the lateral surface of axle smash the tooth is smashed to equal fixedly connected with a plurality of on the upper and lower side of smashing the pole.
According to the invention, the toad feeding insects and cod roes placed in the crushing cylinder can be thoroughly crushed and pulped through the crushing device, the crushing plates are driven to move circumferentially to turn over the toad feeding insects and cod roes through the rotation and up-and-down movement of the conical plates, the toad feeding insects and cod roes are crushed into slurry through the crushing wheels attached to the crushing net cylinder, and the slurry can be continuously sprayed upwards from the plurality of pulping holes when the conical plates move downwards, so that the pulping operation is realized; the slurry in the crushing cylinder can be quickly sprayed into the outer cylinder through the plurality of release grooves at the top of the release plates and is mixed with other raw materials in the outer cylinder, the mixture can be stirred and mixed through the plurality of stirring rods, the slurry can be fully filtered through the plurality of filter press net plates which continuously move up and down, and the slurry can obtain liposome suspension with small and uniform particle size after repeatedly passing through the filter press net plates; can carry out the freeze-drying to the inside liposome of freeze-drying inner tube through the freeze-drying pipe to smash the liposome after with the freeze-drying through a plurality of poles of smashing and be the likepowder back, get rid of from going out the feed cylinder.
Drawings
Fig. 1 is a perspective view of the present invention.
Fig. 2 is a schematic sectional perspective view of the present invention.
FIG. 3 is an enlarged view of the invention at A in FIG. 1.
Fig. 4 is an enlarged view of the invention at B in fig. 2.
Fig. 5 is an enlarged view of the invention at C in fig. 2.
FIG. 6 is a first schematic sectional perspective view of the crushing apparatus of the present invention.
FIG. 7 is a second schematic sectional perspective view of the comminution device of the present invention.
Figure 8 is a schematic cross-sectional plan view of a comminution device according to the invention.
Fig. 9 is an enlarged view of fig. 5 at D according to the present invention.
Fig. 10 is an enlarged view of fig. 8 at E according to the present invention.
Fig. 11 is an enlarged view of fig. 5 at F according to the present invention.
Fig. 12 is a perspective view of the filter press of the present invention.
Fig. 13 is a schematic sectional perspective view of a filter-press apparatus and a freeze-drying apparatus according to the present invention.
Fig. 14 is a schematic cross-sectional plan view of a filter-press apparatus and a freeze-drying apparatus according to the present invention.
Detailed Description
The foregoing and other aspects, features and advantages of the invention will be apparent from the following more particular description of embodiments of the invention, as illustrated in the accompanying drawings in which reference is made to figures 1 to 14. The structural contents mentioned in the following embodiments are all referred to the attached drawings of the specification.
Exemplary embodiments of the present invention will be described below with reference to the accompanying drawings.
The first embodiment of the invention is a toad eating liposome preparation device, which comprises an outer cylinder 1, wherein the bottom of the outer cylinder 1 is provided with supporting legs and can be placed on a table top or a ground for use, the bottom of the outer cylinder 1 is fixedly provided with a discharging cylinder 03, the middle part of the top surface of the outer cylinder 1 is penetrated and fixedly provided with a crushing cylinder 2 which is positioned in the outer cylinder 1 and is provided with an opening at the bottom, the tops of the outer cylinder 1 and the crushing cylinder 2 are respectively provided with a feeding hole, toad eating insects and cod roes, vitamin E and cholesterol can be added into the crushing cylinder 2, powder of other raw materials is added into the outer cylinder 1, the crushing cylinder 2 is internally provided with a crushing device, and the crushing device can crush and pulp the toad eating insects and cod roes in the crushing cylinder 2 into a slurry, a partition plate 01 positioned below the crushing barrel 2 is coaxially and fixedly arranged inside the outer barrel 1, the partition plate 01 divides the inside of the outer barrel 1 into an upper space and a lower space, a filtering and pressing device positioned between the crushing barrel 2 and the partition plate 01 is arranged inside the outer barrel 1, slurry after crushing and pulping treatment in the crushing barrel 2 can enter the space above the partition plate of the outer barrel 1, the slurry is mixed with other raw material powder through the filtering and pressing device and is repeatedly filtered to form liposome suspension with smaller and uniform particle size, a freeze-drying device is arranged at the bottom inside the outer barrel 1, the obtained liposome suspension is freeze-dried and crushed into powder through the freeze-drying device after reaching the bottom of the outer barrel 1, and the liposome freeze-dried into powder in the outer barrel 1 can be discharged from the discharge barrel 3;
the crushing device comprises a spiral rod 3 penetrating through the middle of the top surface of a crushing barrel 2, the spiral rod 3 can rotate at the top of the crushing barrel 2 and can also move up and down at the top, two reciprocating spiral grooves 4 communicated with the head end and the tail end respectively are formed in the outer surface of the spiral rod 3, a spiral sleeve 5 sleeved on the outer side of the spiral rod 3 is fixedly mounted at the top of the crushing barrel 2, a reciprocating pin 6 located in the reciprocating spiral groove 4 is fixed on the inner side surface of the spiral sleeve 5, through the matching of the reciprocating spiral groove 4 and the reciprocating pin 6, when the spiral rod 3 rotates, the spiral reciprocating groove 4 and the reciprocating pin 6 are in relative sliding fit, through the matching of the reciprocating spiral groove 4 and the reciprocating pin 6, the spiral rod can also reciprocate up and down at the top of the crushing barrel 2, and meanwhile, the rotation and the lifting motion of the spiral rod 3 at the top of the crushing barrel 2 are realized;
the coaxial fixed mounting in bottom of 2 medial surfaces of crushing barrel has the top to open the direction ring 7 that has the inclined plane to the axle center slope, the transversal right trapezoid shape that personally submits of direction ring 7, the bottom fixed mounting of direction ring 7 has crushing otter board 8, eat toad and cod roe and drop to crushing otter board 8 after getting into crushing barrel 2, the aperture of crushing otter board 8 is less than the particle diameter of cod roe, the bottom fixedly connected with of hob 3 is located crushing barrel 2 inside and with the sealed sliding fit's of medial surface taper plate 9 of direction ring 7, hob 3 rotates and can drive taper plate 9 and rotate and go up and down in crushing barrel 2 when going up and down, the sealed laminating of lateral surface of taper plate 9 and the medial surface of direction ring 7 to can reciprocate in direction ring 7, it has a plurality of crushing grooves 10 to run through between the bottom surface of taper plate 9 and the top surface, every it has crushing board 11 to all slide mounting from top to bottom in crushing groove 10 has crushing board 11, every the bottom of crushing board 11 all rotates and installs crushing wheel 12, every the bottom of crushing board 11 and every the equal rotating of crushing board 11 and the crushing conical surface of crushing board 10 is equipped with the corresponding position of the top surface of the equal pulping groove 16, the top surface of the crushing spring plug is connected with the top surface of the crushing board 15 of the crushing spring plug of the top surface of the equal pulping hole 16, 16 is equipped with the crushing board 17, the top surface of the crushing spring plug 17, the top surface of the crushing board 17 is equipped with the top surface of the crushing board 17, the equal punch 16 of the crushing board 17 is equipped with the top surface of the crushing spring plug of the crushing board 17, the equal movable plug of the top surface of the crushing board 17 is equipped with the top surface of the crushing board 17, the top surface of the crushing board 17 is equipped with the top surface of the equal punch 16, can block the slurry from passing through the crushing screen plate 8;
when in use, firstly, the screw rod 3 is rotated to drive the conical plate 9 to rotate and do lifting motion in the crushing cylinder 2, under the elastic force of the crushing tension springs 14, the crushing wheels 2 are always contacted with the top surface of the crushing screen plate 8, the conical plate 9 can drive the crushing plates 11 to move circumferentially and turn the toad pests and cod roes in the crushing cylinder 2, the crushing wheels 12 can roll circumferentially along the top surface of the crushing screen plate 8 so as to crush the toad pests and cod roes, when the conical plate 9 moves downwards, the distance between the top ends of the crushing plates 11 and the conical surface of the conical plate 9 is increased, the crushing tension springs 14 are lengthened, the crushing wheels 12 still roll circumferentially along the top surface of the crushing screen plate 8, meanwhile, when the conical plate 9 moves downwards, the toad pests and cod roes can also be crushed downwards, when the conical plate 9 moves into the guide circular ring 7, at the moment, the inside of the guide ring 7 is a closed space, the pressure of the inside slurry is increased, the slurry can enter a plurality of pulping holes 15 and upwards jack a plurality of pulping plugs 17, the slurry is sprayed to the upper part of the conical plate 9 from the tops of the plurality of pulping holes 15, when the conical plate 9 moves upwards to the upper part of the guide ring 7, the slurry flows to the inclined plane of the guide ring 7 along the conical surface of the conical plate 9 and flows to the inside of the guide ring 7 along the inclined plane of the guide ring, then the conical plate 9 continuously carries out the motion process, the toad eating insect and cod roe are fully crushed and rolled by the crushing plate 11 and the crushing wheel 12, and the high-pressure spraying and pulping operation is carried out on the slurry through the plurality of pulping holes 15, so that the mixed slurry of the toad eating insect and the cod roe can be more uniform, and the vitamin E and the cholesterol are added in the crushing cylinder 2 to be fully mixed with the slurry for pulping, after the beating is completed, the crushing seal disk 19 can be moved downward so that the slurry can flow onto the top surface of the crushing seal disk 9 through the crushing mesh plate 8 and flow up onto the top surface of the partition plate 01 inside the outer cylinder 1 from the top surface of the crushing seal disk 19, and then the filtration and freeze-drying processes are performed by the subsequent filtration and compression device and freeze-drying device.
Second embodiment, on the basis of first embodiment, the coaxial fixedly connected with in top of hob 3 smashes gear 20, smashes gear 20 and can drive hob 3 synchronous rotation when rotating to can reciprocate with hob 3 is synchronous, the top fixed mounting of crushing barrel 2 has crushing motor 21, and crushing motor 21 is connected with power supply and switch, coaxial fixed mounting has long gear 22 with crushing gear 20 meshing in the axis of rotation of crushing motor 21, smashes motor 21 and can drive crushing gear 20 when driving long gear 22 to rotate, thereby realizes hob 3's rotation, can drive crushing gear 20 along long gear 22's tooth axial displacement when hob 3 reciprocates for crushing gear 20 still can mesh with long gear and transmission when reciprocating, thereby realizes the rotation and the lift of conical disk 9.
In the third embodiment, on the basis of the first embodiment, two cylinder grooves are formed in the bottom surface of the guide ring 7, the two cylinder grooves are fixedly provided with the pulverizing cylinder 23, the pulverizing cylinder 23 is connected with the power supply and the switch, the telescopic shafts of the two pulverizing cylinders 23 are fixedly connected with the pulverizing sealing disc 19, the telescopic shafts of the two pulverizing cylinders 23 can drive the pulverizing sealing disc 19 to move downwards when being extended, so that the slurry can pass through the pulverizing mesh plate 8, the telescopic shafts of the two pulverizing cylinders 23 can drive the pulverizing sealing disc 19 to move upwards to block the pulverizing mesh plate 8 when being shortened, the top surface of the pulverizing sealing disc 19 is provided with a releasing plate groove 24 with the same diameter as that of the pulverizing mesh plate 8, a releasing plate 25 is coaxially and slidably mounted in the releasing plate groove 24, the diameter of the releasing plate 25 is the same as that of the pulverizing mesh plate 8, and a releasing spring 26 is fixedly connected between the releasing plate 25 and the releasing plate groove 24, the top surface of the releasing plate 25 is provided with a plurality of releasing grooves 52 which are radial and penetrate through the outer side surface, when the crushing sealing plate 19 is jointed with the bottom surface of the crushing screen plate 8, the top surface of the releasing plate 25 is also jointed with the bottom surface of the crushing screen plate 8 under the elastic force of the releasing spring 26, and the releasing spring 26 is in a completely compressed state, when slurry needs to move from the crushing cylinder 2 to the inner part of the outer cylinder 1, the crushing sealing plate 19 can be driven by two crushing cylinders 23 to move downwards, at the moment, the releasing spring 26 can be released and always pushes upwards the releasing plate 25 to be jointed with the bottom surface of the crushing screen plate 8, but when the conical disc 9 moves downwards in the guiding ring 7, the slurry generates pressure on the pulping plug 17 and the releasing plate 25, but because the releasing grooves 52 are arranged on the releasing plate 25, the slurry can pass through the screen plate 8 and then enter the releasing grooves 52, and squirting from the opening of a plurality of relief grooves 52 to the inside of urceolus 1, after the thick liquid in the crushing barrel 2 is totally squirted to the urceolus 1, can upwards remove crushing sealed dish 19 and reset, make the top surface of crushing sealed dish 19 laminate with the bottom surface of crushing otter board 8 again, release plate 25 enters into relief plate groove 24 again at this moment, the opening of a plurality of relief grooves 52 is then stopped up by the inner wall of relief plate groove 24, release spring 26 is then compressed completely, the top surface of release plate 25 laminates with the bottom surface of crushing otter board 8 at this moment, when conical plate 9 moves down and extrudes thick liquid, thick liquid can't be squirted from a plurality of relief grooves 52, thick liquid then can upwards push open a plurality of beating plugs 17 and carry out the beating operation, when needing to get rid of thick liquid, again can do the above-mentioned operation.
In the fourth embodiment, on the basis of the third embodiment, the filtering and pressing device includes a filtering and pressing rod 27 coaxially and fixedly connected with the bottom of the conical plate 9, and the bottom end of the filtering and pressing rod 27 penetrates through the crushing screen plate 8 and the crushing sealing disc 19, when the conical plate 9 rotates and goes up and down, the filtering and pressing rod 27 can be driven to rotate and go up and down in the outer cylinder 1, a telescopic groove 28 is formed in the middle of the bottom surface of the filtering and pressing rod 27, a stirring shaft 29 is coaxially and slidably installed in the telescopic groove 28, a stirring spring 30 fixedly connected with the stirring shaft 29 is fixedly installed in the telescopic groove 28, the bottom end of the stirring spring 30 of the stirring shaft 29 is always attached to the top surface of the partition plate 01 under the elastic force action of the stirring spring 30, when the filtering and pressing rod 27 rotates, the stirring shaft 29 can be driven to rotate, when the filtering and pressing rod 27 moves up and down, the stirring shaft 29 can axially slide relative to the stirring shaft 29, a plurality of stirring rods 31 attached to the top surface of the partition plate 01 are fixedly installed on the outer side surface of the bottom end of the stirring rod 29, every the equal a plurality of stirring teeth 32 of fixedly connected with in top of puddler 31, (mixing) shaft 29 can mix stirring slurry and other raw materials powder through a plurality of puddlers 31 and a plurality of stirring teeth 32 when rotating, fixed mounting has a plurality ofly and the crisscross fan-shaped filter press frame 33 that sets up of a plurality of puddlers 31 on the lateral surface of filter press pole 27 bottom, every the inside fixed mounting of fan-shaped filter press frame 33 has filter press net board 34, and filter press pole 27 can drive a plurality of fan-shaped filter press frames 33 and filter press net board 34 when the inside up-and-down motion of urceolus 1 and reciprocate for the slurry can pass through filter press net board 34 repeatedly, and filter press net board 34 adopts the stainless steel micropore filter, carries out filtration repeatedly to the slurry through filter press net board 34, thereby obtains the less and even liposome suspension of particle size.
In the fifth embodiment, on the basis of the fourth embodiment, four long grooves 35 penetrate through between the top surface and the bottom surface of the partition plate 01, a cross plate 36 located below the partition plate 01 is vertically slidably mounted in the outer cylinder 1, sealing plugs 37 matched with the four long grooves 35 are fixedly mounted at the top of the cross plate 36, the cross plate 36 can vertically slide below the partition plate 01, when the cross plate slides upwards, the four sealing plugs 37 can block the four long grooves 35, and when the cross plate slides downwards, the four sealing plugs 37 can open the four long grooves 35, so that liposomal suspension located above the partition plate 01 can flow into a space below the partition plate 01 through the four long grooves 35.
Sixth embodiment, on the basis of fifth embodiment, the partition cylinder 38 penetrates through and is fixedly installed in the middle of the cross plate 36, the telescopic shaft of the partition cylinder 38 is fixedly connected with the bottom of the partition 01, the partition cylinder 38 is connected with a power supply and a switch, and when the telescopic shaft of the partition cylinder 38 extends, the cross plate 36 can be driven to move downwards, and when the telescopic shaft of the partition cylinder 38 extends, the cross plate 36 can be driven to move upwards.
Seventh embodiment, on the basis of the first embodiment, the freeze-drying device includes a freeze-drying inner cylinder 39 fixedly installed at the bottom end inside the outer cylinder 1, the top edge of the freeze-drying inner cylinder 39 is fixedly connected with the inner wall of the outer cylinder 1 in a sealing manner through a flange, the liposome suspension passes through the four long grooves 35 and then reaches the interior of the freeze-drying inner cylinder 39, a freeze-drying tube 40 is installed between the inner side surface of the outer cylinder 1 and the outer side surface of the freeze-drying inner cylinder 39, and cold air or liquid nitrogen can be filled into the freeze-drying tube 40, so that the liposome suspension is freeze-dried.
Eight embodiment, on the basis of embodiment seven, go out the top of feed cylinder 03 and upwards run through freeze-drying inner tube 39, it has discharge gate 04 to open on its bottom is sealed and the side, installs the valve on the discharge gate 04, and the liposome suspension gets into freeze-drying inner tube 39 after, has some to get into in the feed cylinder 03 and by freeze-drying, the bottom fixed mounting who goes out feed cylinder 03 breaks motor 41, breaks motor 41 and is connected with power supply and switch, the coaxial fixed mounting of pivot that breaks motor 41 has a discharge auger 42 that is located feed cylinder 03 inside, can smash the liposome suspension in the feed cylinder 03 when discharge auger 42 rotates, the coaxial fixedly connected with in top of discharge auger 42 is located the axle 43 of smashing in freeze-drying inner tube 39, and discharge auger 42 can drive a plurality of pole 44 of smashing and smash the motion of tooth 45 when smashing axle 43 and rotating to smash the liposome after being powdered, finally can open the valve and arrange from discharge gate 04.
Claims (8)
1. A toad feeding liposome preparation device comprises an outer barrel (1), wherein a discharge barrel (03) is fixedly installed at the bottom of the outer barrel (1), and is characterized in that a crushing barrel (2) which is positioned in the outer barrel (1) and has an opening at the bottom is fixedly installed in the middle of the top surface of the outer barrel in a penetrating manner, a crushing device is installed in the crushing barrel (2), a partition plate (01) which is positioned below the crushing barrel (2) is coaxially and fixedly installed in the outer barrel (1), a pressure filtering device which is positioned between the crushing barrel (2) and the partition plate (01) is installed in the outer barrel (1), and a freeze-drying device is installed at the bottom in the outer barrel (1);
the smashing device comprises a screw rod (3) penetrating through the middle of the top surface of a smashing barrel (2), two reciprocating spiral grooves (4) communicated with the head end and the tail end are formed in the outer surface of the screw rod (3), a spiral sleeve (5) sleeved outside the screw rod (3) is fixedly arranged at the top of the smashing barrel (2), a reciprocating pin (6) located in the reciprocating spiral groove (4) is fixedly arranged on the inner side surface of the spiral sleeve (5), a guide circular ring (7) with an inclined surface inclined towards the axis is arranged at the top of the coaxial fixed mounting at the bottom of the inner side surface of the smashing barrel (2), a smashing screen plate (8) is fixedly arranged at the bottom of the guide circular ring (7), a smashing screen plate (11) is fixedly connected to the bottom of the screw rod (3) and is arranged inside the smashing barrel (2) in a sealing sliding fit manner with the inner side surface of the guide circular ring (7), a plurality of smashing grooves (10) penetrate between the bottom surface and the top surface of the conical plate (9), a smashing groove (11) is vertically and is provided with a smashing tension spring (13) and a smashing spring (12) is arranged between the top surface of the smashing groove (9), run through between the bottom surface of conical plate (9) and the top surface and have a plurality of beating holes (15), on the conical surface of conical plate (9) and be located the equal fixed mounting in the outside of every beating hole (15) have guide bar (16) two, per two slidable mounting has on guide bar (16) with beating hole (15) complex beating stopper (17), every all overlap on guide bar (16) and be equipped with beating spring (18) of being connected with beating stopper (17), slidable mounting has crushing sealed dish (19) about the bottom of smashing otter board (8).
2. The toad-eating liposome preparation device according to claim 1, wherein a crushing gear (20) is coaxially and fixedly connected to the top of the screw rod (3), a crushing motor (21) is fixedly installed on the top of the crushing cylinder (2), and a long gear (22) meshed with the crushing gear (20) is coaxially and fixedly installed on a rotating shaft of the crushing motor (21).
3. The toad feeding liposome preparation device according to claim 1, wherein the bottom surface of the guide ring (7) is provided with two cylinder grooves, the two cylinder grooves are fixedly provided with crushing cylinders (23), the telescopic shafts of the two crushing cylinders (23) are fixedly connected with the crushing sealing disc (19), the top surface of the crushing sealing disc (19) is provided with release plate grooves (24) with the same diameter as that of the crushing net plate (8), the release plate grooves (24) are coaxially and slidably provided with release plates (25), release springs (26) are fixedly connected between the release plates (25) and the release plate grooves (24), and the top surface of each release plate (25) is provided with a plurality of radial release grooves (52) penetrating through the outer side surface of the release plate.
4. The buformin-eating liposome preparation device as claimed in claim 3, wherein said filter-pressing device comprises a filter-pressing rod (27) which is coaxially and fixedly connected with the bottom of the conical plate (9) and has a bottom end penetrating through the pulverizing mesh plate (8) and the pulverizing sealing disc (19), a telescopic groove (28) is opened in the middle of the bottom surface of the filter-pressing rod (27), a stirring shaft (29) is coaxially and slidably mounted in the telescopic groove (28), a stirring spring (30) fixedly connected with the stirring shaft (29) is fixedly mounted in the telescopic groove (28), a plurality of stirring rods (31) attached to the top surface of the partition plate (01) are fixedly mounted on the outer side surface of the bottom end of the stirring rod (29), each stirring rod (31) is fixedly connected with a plurality of stirring teeth (32), a plurality of fan-shaped filter-pressing frames (33) staggered with the plurality of stirring rods (31) are fixedly mounted on the outer side surface of the bottom end of the filter-pressing rod (27), and a filter-pressing mesh plate (34) is fixedly mounted inside the fan-shaped filter-pressing frame (33).
5. The device for preparing toad-eating liposome according to claim 4, wherein four long grooves (35) penetrate through the top surface and the bottom surface of the partition plate (01), a cross plate (36) positioned below the partition plate (01) is vertically and slidably mounted in the outer cylinder (1), and sealing plugs (37) matched with the four long grooves (35) are fixedly mounted at the top of the cross plate (36).
6. The device for preparing the toad feeding liposome according to claim 5, wherein a partition cylinder (38) penetrates through and is fixedly installed in the middle of the cross plate (36), and a telescopic shaft of the partition cylinder (38) is fixedly connected with the bottom of the partition (01).
7. The toad-eating liposome preparation device according to claim 1, wherein the freeze-drying device comprises a freeze-drying inner cylinder (39) fixedly installed at the bottom end of the inner part of the outer cylinder (1), and a freeze-drying tube (40) is installed between the inner side surface of the outer cylinder (1) and the outer side surface of the freeze-drying inner cylinder (39).
8. The device for preparing the toad venom liposome according to claim 7, wherein the top of the discharge barrel (03) upwards penetrates through the freeze-drying inner barrel (39), the bottom of the discharge barrel (03) is sealed, the side of the bottom of the discharge barrel is provided with the discharge hole (04), the bottom of the discharge barrel (03) is fixedly mounted with the smashing motor (41), the coaxial fixed mounting of the rotating shaft of the smashing motor (41) is provided with the discharge auger (42) positioned in the discharge barrel (03), the coaxial fixedly connected with at the top of the discharge auger (42) is provided with the smashing shaft (43) in the freeze-drying inner barrel (39), the outer side surface of the smashing shaft (4) is provided with a plurality of smashing rods (44), and each of the upper side surface and the lower side surface of the smashing rods (44) is provided with a plurality of smashing teeth (45).
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| CN202211353348.XA CN115591463B (en) | 2022-11-01 | 2022-11-01 | Toad pest liposome preparation device |
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN116396857A (en) * | 2023-05-20 | 2023-07-07 | 广东圣蜜生物科技有限公司 | Enzymolysis device for extracting polypeptide skin care products and use method |
| CN116510390A (en) * | 2023-06-19 | 2023-08-01 | 山西省水利建筑工程局集团有限公司 | Drainage structure for tunnel construction and drainage method thereof |
Citations (25)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20050002275A1 (en) * | 2003-07-02 | 2005-01-06 | Spx Corporation | Axial-pumping impeller apparatus and method for magnetically-coupled mixer |
| US20090180933A1 (en) * | 2006-04-22 | 2009-07-16 | Bayer Technology Services Gmbh | Reactor |
| US20110253823A1 (en) * | 2009-08-20 | 2011-10-20 | Teoss Co., Ltd. | Raw silicon crusher |
| GB201217488D0 (en) * | 2012-09-28 | 2012-11-14 | Seward Ltd | Blender |
| US20140286714A1 (en) * | 2013-03-08 | 2014-09-25 | Xyleco, Inc. | Processing materials |
| CN108144530A (en) * | 2017-12-28 | 2018-06-12 | 天津鑫源广泰新材料科技有限公司 | A kind of solid-liquid chemical raw material blending tank |
| CN108311257A (en) * | 2018-02-05 | 2018-07-24 | 马奔腾 | A kind of oiliness compound preparation production raw material grinding system |
| CN208878674U (en) * | 2018-10-10 | 2019-05-21 | 南京芬钢环保科技有限公司 | It is a kind of for smelting the multiple stage crushing screening process system of steel slag |
| CN209188909U (en) * | 2018-09-30 | 2019-08-02 | 上海杏家医疗科技有限公司 | A kind of placenta freeze-drying milling device |
| CN209968487U (en) * | 2019-05-16 | 2020-01-21 | 江西红星变性淀粉有限公司 | Modified starch processing is with stoving reducing mechanism |
| CN110801915A (en) * | 2019-10-30 | 2020-02-18 | 刘效杨 | Stable kibbling reducing mechanism is used in traditional chinese medicine drink processing |
| CN210097470U (en) * | 2019-04-08 | 2020-02-21 | 北京航洋健康科技有限公司 | Soaking tank |
| JP2021030211A (en) * | 2019-08-16 | 2021-03-01 | 童浩 | Extraction equipment of ingredient of chinese herbal medicine |
| CN112547183A (en) * | 2020-11-13 | 2021-03-26 | 河南泓医药业有限公司 | Production device and production method of dried motherwort (freeze-dried) |
| CN212856039U (en) * | 2020-06-28 | 2021-04-02 | 合肥维你维喜生物科技有限公司 | Fruit mud processing reducing mechanism |
| CN112934088A (en) * | 2021-01-29 | 2021-06-11 | 安徽古之滕药业有限公司 | Probiotics is mixer for freeze-dried powder processing |
| CN214416301U (en) * | 2021-02-24 | 2021-10-19 | 土默特左旗蒙奥佳饲料有限责任公司 | Agitating unit for feed processing with control by temperature change function |
| CN113578497A (en) * | 2021-08-18 | 2021-11-02 | 重庆披荆斩棘科技有限公司 | Nutrient substance screening equipment and using method |
| CN113788234A (en) * | 2021-09-29 | 2021-12-14 | 深圳市晓帆宇科技有限公司 | Automatic three-dimensional warehousing system |
| CN215541468U (en) * | 2020-11-30 | 2022-01-18 | 张晴晴 | Civil engineering waste material processing apparatus for building with multistage crushing function |
| CN114289128A (en) * | 2021-12-27 | 2022-04-08 | 徐州智奇机械科技有限公司 | Thermal expansion cooling crack deformation type mining machinery crushing device |
| CN114377785A (en) * | 2021-12-30 | 2022-04-22 | 徐州优盛农业科技发展有限公司 | Environment-friendly wheat shredding device based on pretreatment |
| CN114669376A (en) * | 2022-03-24 | 2022-06-28 | 刘阿敏 | Traditional chinese medical science surgery medicine grinds filter equipment |
| CN115121320A (en) * | 2022-07-08 | 2022-09-30 | 石家庄市扬翔饲料有限公司 | Crushing apparatus and contain its production system |
| CN115228362A (en) * | 2022-07-21 | 2022-10-25 | 浙江科露宝食品有限公司 | Wet process mixing device for producing powdery food |
-
2022
- 2022-11-01 CN CN202211353348.XA patent/CN115591463B/en active Active
Patent Citations (25)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20050002275A1 (en) * | 2003-07-02 | 2005-01-06 | Spx Corporation | Axial-pumping impeller apparatus and method for magnetically-coupled mixer |
| US20090180933A1 (en) * | 2006-04-22 | 2009-07-16 | Bayer Technology Services Gmbh | Reactor |
| US20110253823A1 (en) * | 2009-08-20 | 2011-10-20 | Teoss Co., Ltd. | Raw silicon crusher |
| GB201217488D0 (en) * | 2012-09-28 | 2012-11-14 | Seward Ltd | Blender |
| US20140286714A1 (en) * | 2013-03-08 | 2014-09-25 | Xyleco, Inc. | Processing materials |
| CN108144530A (en) * | 2017-12-28 | 2018-06-12 | 天津鑫源广泰新材料科技有限公司 | A kind of solid-liquid chemical raw material blending tank |
| CN108311257A (en) * | 2018-02-05 | 2018-07-24 | 马奔腾 | A kind of oiliness compound preparation production raw material grinding system |
| CN209188909U (en) * | 2018-09-30 | 2019-08-02 | 上海杏家医疗科技有限公司 | A kind of placenta freeze-drying milling device |
| CN208878674U (en) * | 2018-10-10 | 2019-05-21 | 南京芬钢环保科技有限公司 | It is a kind of for smelting the multiple stage crushing screening process system of steel slag |
| CN210097470U (en) * | 2019-04-08 | 2020-02-21 | 北京航洋健康科技有限公司 | Soaking tank |
| CN209968487U (en) * | 2019-05-16 | 2020-01-21 | 江西红星变性淀粉有限公司 | Modified starch processing is with stoving reducing mechanism |
| JP2021030211A (en) * | 2019-08-16 | 2021-03-01 | 童浩 | Extraction equipment of ingredient of chinese herbal medicine |
| CN110801915A (en) * | 2019-10-30 | 2020-02-18 | 刘效杨 | Stable kibbling reducing mechanism is used in traditional chinese medicine drink processing |
| CN212856039U (en) * | 2020-06-28 | 2021-04-02 | 合肥维你维喜生物科技有限公司 | Fruit mud processing reducing mechanism |
| CN112547183A (en) * | 2020-11-13 | 2021-03-26 | 河南泓医药业有限公司 | Production device and production method of dried motherwort (freeze-dried) |
| CN215541468U (en) * | 2020-11-30 | 2022-01-18 | 张晴晴 | Civil engineering waste material processing apparatus for building with multistage crushing function |
| CN112934088A (en) * | 2021-01-29 | 2021-06-11 | 安徽古之滕药业有限公司 | Probiotics is mixer for freeze-dried powder processing |
| CN214416301U (en) * | 2021-02-24 | 2021-10-19 | 土默特左旗蒙奥佳饲料有限责任公司 | Agitating unit for feed processing with control by temperature change function |
| CN113578497A (en) * | 2021-08-18 | 2021-11-02 | 重庆披荆斩棘科技有限公司 | Nutrient substance screening equipment and using method |
| CN113788234A (en) * | 2021-09-29 | 2021-12-14 | 深圳市晓帆宇科技有限公司 | Automatic three-dimensional warehousing system |
| CN114289128A (en) * | 2021-12-27 | 2022-04-08 | 徐州智奇机械科技有限公司 | Thermal expansion cooling crack deformation type mining machinery crushing device |
| CN114377785A (en) * | 2021-12-30 | 2022-04-22 | 徐州优盛农业科技发展有限公司 | Environment-friendly wheat shredding device based on pretreatment |
| CN114669376A (en) * | 2022-03-24 | 2022-06-28 | 刘阿敏 | Traditional chinese medical science surgery medicine grinds filter equipment |
| CN115121320A (en) * | 2022-07-08 | 2022-09-30 | 石家庄市扬翔饲料有限公司 | Crushing apparatus and contain its production system |
| CN115228362A (en) * | 2022-07-21 | 2022-10-25 | 浙江科露宝食品有限公司 | Wet process mixing device for producing powdery food |
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN116396857A (en) * | 2023-05-20 | 2023-07-07 | 广东圣蜜生物科技有限公司 | Enzymolysis device for extracting polypeptide skin care products and use method |
| CN116396857B (en) * | 2023-05-20 | 2023-09-01 | 广东圣蜜生物科技有限公司 | Enzymolysis device for extracting polypeptide skin care products and use method |
| CN116510390A (en) * | 2023-06-19 | 2023-08-01 | 山西省水利建筑工程局集团有限公司 | Drainage structure for tunnel construction and drainage method thereof |
| CN116510390B (en) * | 2023-06-19 | 2023-09-12 | 山西省水利建筑工程局集团有限公司 | Drainage structure for tunnel construction and drainage method thereof |
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