KR20080089059A - An extraction method of ginseng ingredients and ginseng liquor having ingredients manufactured by using the same - Google Patents

Abstract

An extraction method of the effective ingredients of ginseng, and medicinal ginseng wine prepared by the method are provided to extract the effective ingredients of ginseng without destroying or transforming their molecules by using ultrasonic waves. An extraction method of the effective ingredients of ginseng comprises the steps of: preparing ginseng(S1); stirring the ginseng with a solvent in an indirect ultrasonic wave extractor placed at a fixed distance apart from a vibrator to extract the effective ingredients of ginseng at room temperature(S2); filtering the extract to obtain a liquid containing the effective ingredients of ginseng(S3); and diluting the liquid(S4). In the step (S2), the solvent is one selected from distilled water and ethanol. Medicinal ginseng wine comprises the effective ingredients extracted by the method.

Description

Extraction method of ginseng active ingredient and ginseng medicine prepared by this method {An extraction method of ginseng ingredients and ginseng liquor having ingredients manufactured by using the same}

1 is a flow chart illustrating a method of extracting ginseng active ingredient using ultrasonic waves according to the present invention.

2 and 3 are a cross-sectional view and a plan view showing a ginseng active ingredient extraction apparatus using ultrasonic waves according to an embodiment of the present invention.

4 and 5 are a cross-sectional view and a plan view showing a ginseng active ingredient extracting apparatus using ultrasonic waves according to another embodiment of the present invention.

The present invention relates to a method for extracting ginseng active ingredient and ginseng medicine prepared by the method, and more particularly, to a method for extracting ginseng active ingredient using ultrasonic waves and ginseng medicine prepared by the method.

Many researches have been made on the main ingredients and pharmacological effects of ginseng, and as scientifically its effect has been spotlighted as a health food. The effects of herbal ginseng known to this day are to strengthen the mind and body, improve the weak physical strength, improve stamina and recover the fatigue, and promote the production of blood in the body, which promotes blood circulation and functions of each organ. And improves development.

In addition, it strengthens the heart function and helps to relieve nervous breakdowns, neuroses, stress, etc., and has a great effect on the treatment of diabetes by strengthening the spleen function, and by reinforcing the respiratory function, it has an excellent effect on the prevention and treatment of respiratory diseases. have.

In addition, it enhances gastrointestinal function, promotes food consumption, and is effective in the treatment and prevention of gastrointestinal disorders, and makes skin clean and resistant to boils.

The main active ingredient of ginseng having such efficacy is known as a total of about 30 kinds of saponin components called ginsenosides. Glycosides of ginseng saponins include panaxadiol, panaxtriol, β-cytosterol, and oleanolic acid, and the fragrance inherent to panaxen, polyacetylene, which is toxic to any heterologous cell. Compounds and the like are known, and peptides are also effective in diabetes by acting like insulin. Ginseng stems and leaves contain flavonoids such as camphorol, tripolim and panacenoid. Vitamins include B complex, nicotinic acid, pantothenic acid, folic acid, and biotin, and trace inorganic elements include manganese, copper, vanadium, cobalt, arsenic, germanium, phosphorus, aluminum, nickel, etc., which are aged through germanium cytotoxicity. It has the effect of promoting the transformation of cells into neoplastic cells and also has anti-cancer effects. It was found that the enzyme components include amylase and phenolase enzyme, and other red ginseng contained maltol, which has antioxidant activity, and 21 kinds of amino acids and 24 kinds of free fatty acids.

Various methods are known for extracting the active ingredient of such ginseng.

First, there is usually a method of extracting hot water under high temperature and high pressure, purifying it, and then diluting it with necessary additives such as distilled water or ethanol. Korean Patent No. 517128 "Method of Extracting Active Ingredients from Ginseng and Red Ginseng" discloses a method of extracting several active ingredients in a continuous process by sequentially using extraction solvents of water, ethanol and petroleum ethanol and changing extraction conditions. have. However, the method of extracting hot water under high temperature and high pressure causes the protein molecules to be destroyed or modified in the process and thus it is impossible to extract the fresh natural active substance.

Second, there is a method of pulverizing ginseng and dissolving it in distilled water or an organic solvent and then purifying it. However, this method takes a long time of at least 18 hours to 36 hours extraction time, there is a problem in that to extract the ginseng repeatedly or to use a large amount of raw materials in order to obtain the desired active ingredient in the natural state.

Third, there is a method of directly irradiating the ginseng with the solvent and purifying it. Korean Patent Registration Publication No. 92-8357, "Extraction method of ginseng extract" discloses a method of effectively extracting the active ingredient of ginseng using an ultrasonic extractor from the finely ground ginseng root. In this way, the method of directly irradiating ginseng with ultrasonic solvent and purifying it is very efficient, so it is easy to extract the active ingredient, but nano-sized fine metal particles are present in the extracted active ingredient, which is dangerous to the human body. There is a necessity for a post-treatment method so that this is not possible. In other words, a large economic cost is required to separate the minute harmful substances and active ingredients.

In order to solve the problems of the prior art as described above, the present invention provides a method for extracting ginseng active ingredient and ginseng medicine prepared by the method does not need to modify the active ingredient of ginseng at room temperature and does not require a separate chemical post-treatment process It aims to do it.

In order to achieve the above object, the method of extracting ginseng active ingredient of the present invention prepares ginseng raw material, stirs the raw material together with a solvent in an indirect ultrasonic extraction device spaced a predetermined distance from the vibrator, and the ginseng active ingredient at room temperature. After extracting from the ginseng active ingredient is extracted through a filtration process through a filter device to obtain a solution containing the ginseng active ingredient.

In the present invention, the solvent is preferably any one selected from distilled water or spirits.

In the present invention, the method may further include diluting the solution containing the active ingredient.

In the present invention, the indirect ultrasonic extraction apparatus is an extraction tank for receiving the extraction object and the extraction solvent, a vibrating portion disposed to extend up and down in the central portion of the extraction tank, a predetermined distance from the vibration portion and separated from the extraction object and the vibration portion It may be composed of an ultrasonic transmission material impregnated in the extraction tank and filled in the space in the transmission plate including the transmission plate and the vibration unit for transmitting the ultrasonic wave generated in the vibration unit to the extraction object.

In the present invention, the indirect ultrasonic extraction apparatus is an extraction tank for receiving the extraction object and the extraction solvent, a vibration unit disposed to surround the outside of the extraction tank, a predetermined distance from the vibration unit and arranged to separate the extraction object and the vibration unit It may be composed of a transmission tube for transmitting the ultrasonic wave generated in the eastern part to the extraction object, and the ultrasonic transmission material filled in the space in the transmission plate including the vibration unit.

Ginseng medicine of the present invention includes an active ingredient extracted by the above-described ultrasonic extraction method.

The above objects, features and advantages will become more apparent from the following detailed description taken in conjunction with the accompanying drawings. Hereinafter, exemplary embodiments of the present invention will be described in detail with reference to the accompanying drawings.

1 is a flow chart illustrating a method of extracting ginseng active ingredient using ultrasonic waves according to the present invention.

First, the ginseng raw material is pretreated (S1). In the case of using dried raw materials, the dried raw materials are finely crushed in a washing machine or a ball mill after washing and drying. In case of using a moisture-containing raw material, it is cut finely by dipping in distilled water or alcohol to prevent oxidation.

Next, after the pretreatment, the raw material is stirred with a solvent such as distilled water or alcohol in an ultrasonic extraction apparatus to extract the active ingredient from ginseng at room temperature (S2). Ultrasonic extraction is carried out at room temperature, the temperature range is 10 to 20 degrees Celsius, it is generally most effective to extract between 20 to 30 degrees Celsius. The weight ratio between solvent and raw materials ranges from 8: 2 to 2: 8, and the optimum conditions vary depending on the raw materials.

Next, a solution in which the active ingredient is dissolved is taken through a filtration step of passing the resultant from which the active ingredient is extracted (S3).

Next, a dilution process for diluting the solution containing the active ingredient as necessary finally (S4).

2 and 3 are a cross-sectional view and a plan view showing an active ingredient extracting apparatus using ultrasonic waves according to an embodiment of the present invention.

Referring to FIGS. 2 and 3, an extraction tank 100 surrounded by a shell 112 and covered with an upper lid 110 is formed. Inlet (108) and the outlet (Outlet, 111) is disposed in the extraction tank 100, the extraction object and the extraction solvent may be introduced or discharged. A vibration part 103 is disposed to be impregnated so as to extend up and down at a central portion in the extraction tank 100 accommodating the extraction object and the extraction solvent, and the extraction tank 100 spaced apart from the vibration part 103 by a predetermined distance. The transmitting part (109) is arranged to be separated from the space of). The vibrator 103 is connected to the upper plate 110 through the transmission plate 109 and the connector 102. The transmission plate 109 transmits the ultrasonic waves generated by the vibrator 103 to the extraction object, and includes an ultrasonic transfer material 107 filled in the space in the transmission plate 109 including the vibrator 103. do. Ultrasonic delivery material 107 is a liquid material with good electrical conductivity of the ultrasound is possible, preferably in terms of ease of use and cost, it is preferable to use a medium that can extract the most extracts efficiently. In addition, the portion containing the extraction target of the extraction tank 100 may be configured to further include one or two or more impellers (Impeller, 105) driven by the stirring device (Agitater, 104) such as a motor. Through this, the material movement in the extraction tank 100 can be made more active, and the extraction of the object to be extracted can be made easier. In addition, a baffle plate 106 may be installed at the lower portion of the extraction tank 100 so that the irradiation of the ultrasonic waves is evenly performed on all the extraction objects. The impeller 105 may be applied to a shape used for a well-known extraction device or agitator, and the arrangement of the impeller 105 located on each axis may be in any form, and preferably, the impeller 105 connected to two shafts. Can be arranged to be parallel to each other. The vibrator 103 may use an ultrasonic generator vibrator applied to a known ultrasonic extraction device, and the vibrator 103 is connected to and driven by an oscillator 101 to generate ultrasonic waves.

The permeable plate 109 impregnated in the extraction vessel 100, which is a feature of the present invention, performs two functions together. First, the extraction tank 100 is separated into two spaces by being spaced apart at regular intervals from the vibration unit 103 in the vibration space. Therefore, the extraction tank 100 is separated into a portion containing the extract object and a portion containing the ultrasonic wave transmission material, each part is separated from the impossible movement of the material, the extract object and the vibrator 103 is substantially in contact with It does not occur. On the other hand, the ultrasonic wave generated from the vibrator 103 is transmitted to the transmission plate 109 through the ultrasonic transfer material 107 and to the extraction object through the transmission plate 109. The transmissive plate 109 is preferably thin enough to sufficiently reduce the output of the ultrasonic wave. That is, it may be an inert thin plate having a thickness of 0.2 to 0.5 mm, and is preferably a thin plate made of an inert material with an ultrasonic transfer material or an extraction solvent.

4 and 5 are a cross-sectional view and a plan view showing an active ingredient extracting apparatus using ultrasonic waves according to another embodiment of the present invention.

4 and 5, a jacket shell 212 is connected to a connector 213. A connector is formed to accommodate an extraction tank. The extraction tank 200 covered with the upper lid 210 is formed in the space formed by the outer shell 212. Inlet (not shown) and the outlet (Outlet, 211) is disposed in the extraction tank 200 may be the extraction object and the extraction solvent is introduced or discharged. A vibration panel 203 is disposed surrounding the outside of the extraction tank 200 for receiving the extraction object and the extraction solvent, and a vibrator 202 is connected to the vibration unit 203. A transmitting drum 209 is disposed to be separated from the space of the extraction tank 200 at a predetermined distance from the vibrator 203. The transmission cylinder 209 includes an ultrasonic transfer material 207 filled in a space in the transmission cylinder 209 for transmitting the ultrasonic wave generated from the vibrator 203 to the extraction object. Vibration absorbers 208 may be disposed at upper and lower ends of the transmission cylinder 209, respectively. The transmission tube 209 may allow the ultrasonic transfer material 207 to enter or exit in the direction of the arrow. The ultrasonic transfer material 207 may be any liquid material having good conductivity of ultrasonic waves, and preferably, a medium capable of efficiently extracting the extract material most efficiently in terms of ease of use and cost. In addition, the central portion of the portion containing the extraction target of the extraction tank 200 may be configured to further include an impeller (205) driven by an agitation device (204) such as a motor. Through this, the material movement in the extraction tank 200 can be made more active, and the extraction of the object to be extracted can be made easier. In addition, a baffle plate 206 may be installed in the lower portion of the extraction tank 200 so that the irradiation of the ultrasonic waves is evenly performed on all the extraction objects. The vibrator 203 may use an ultrasonic generator vibrator 202 applied to a known ultrasonic extraction device, and the vibrator 203 is connected to and driven by a generator 201 to generate ultrasonic waves.

The transmission cylinder 209 surrounding the extraction vessel 200 which is a feature of the present invention performs two functions together. First, the extraction tank 200 is separated into two spaces by being spaced apart at regular intervals from the vibration unit 203 in the vibration space. Therefore, the extraction tank 200 is separated into a portion containing the extract object and the portion containing the ultrasonic wave transmission material 207, each part is isolated to be impossible to move the material, the extract object and the vibrating portion 203 is Substantial contact does not occur. On the other hand, the ultrasonic wave generated from the vibrator 203 is transmitted to the transmission cylinder 209 through the ultrasonic transmission material 207 and to the extraction object through the transmission cylinder 209. Transmissive cylinder 209 is preferably thin enough to reduce the output of the ultrasonic wave sufficiently. That is, it may be an inert thin plate having a thickness of 0.2 to 0.5 mm, and is preferably a thin plate made of an inert material with an ultrasonic transfer material or an extraction solvent.

Thus, the present invention can extract the active ingredient of ginseng, ginseng medicine can be prepared when using alcohol as a solvent.

Table 1 shows the amount of natural saponin (crude saponin) measured after recovering the alcohol after preparing the medicine by time at room temperature using the red ginseng according to the embodiment as a raw material (10g).

Manufacturing time (HRs) 2 4 6 8 Saponin wt 193.20 mg / g 198.13 mg / g 204.50 mg / g 206.48 mg / g

Table 2 shows the amount of ginsenosides measured under the same conditions for the same raw material.

Manufacturing time (HRs) 2 4 6 8 Ginsenoside wt 100.05mg / g 125.03mg / g 135.03mg / g 148.61 mg / g

Table 3 shows the types and amounts of polysaccharides measured under the same conditions for the same raw materials.

Manufacturing time (HRs) 2 4 6 8 Rhamnose 0.01mg / g 0.04 mg / g 0.32mg / g 0.35mg / g Xylose 0.01mg / g 0.15mg / g 0.18 mg / g 0.19mg / g Fructose 5.25mg / g 8.72mg / g 12.92mg / g 17.79 mg / g Glucose 2.53mg / g 3.78mg / g 12.55mg / g 19.4mg / g Sucrose 91.52mg / g 80.67mg / g 72.90 mg / g 71.71mg / g Maltose 32.17 mg / g 26.85mg / g 10.33 mg / g 12.00mg / g

The present invention described above is not limited to the above-described drawings and detailed description, and various modifications and changes made by those skilled in the art without departing from the spirit and scope of the present invention described in the claims below. Of course, it is also included within the scope of the present invention.

As described above, the present invention can proceed to the extraction process at room temperature to extract the active ingredient of ginseng without molecular breakdown or modification of the active ingredient of ginseng.

In addition to the saponins, various effective ingredients of ginseng such as polysaccharides and polyacetylene having excellent pharmacological effects can be effectively obtained simultaneously.

In addition, since the vibrator and ginseng, which is an extract object, do not directly contact in the ultrasonic extraction process, nano-sized metal impurities are not included in the ultrasonic wave, and thus no additional chemical post-treatment is performed.

In addition, the ginseng active ingredient according to the present invention contains a variety of active ingredients in a natural state, it is possible to manufacture a therapeutic medicine high productivity and economical.

Claims (6)

Preparing ginseng raw materials; Extracting the ginseng active ingredient from the raw material at room temperature by stirring the raw material with a solvent in an indirect ultrasonic extraction apparatus spaced apart from the vibrator by a predetermined distance; And Method of extracting the ginseng active ingredient comprising the step of obtaining a solution containing the ginseng active ingredient through a filtration step of passing the resultant extracted the ginseng active ingredient through a filter device. The method of claim 1, The solvent is an extract method of the ginseng active ingredient, characterized in that any one selected from distilled water or spirits. The method of claim 1, Method of extracting ginseng active ingredient, characterized in that it further comprises the step of diluting the solution containing the active ingredient. The method of claim 1, The indirect ultrasonic extraction device, An extraction tank accommodating an extraction object and an extraction solvent; Vibration unit disposed to extend up and down in the central portion of the extraction tank; A transmission plate spaced apart from the vibrating unit by a predetermined distance and impregnated in the extraction tank so as to separate the extract object from the vibrating unit, and transmitting ultrasonic waves generated from the vibrating unit to the extract object; And Extracting method of the ginseng active ingredient, characterized in that it comprises an ultrasonic delivery material filled in the space in the transmission plate including the vibration. The method of claim 1, The indirect ultrasonic extraction device, An extraction tank accommodating an extraction object and an extraction solvent; A vibrator arranged to surround the outside of the extraction tank; A transmission tube spaced apart from the vibrating unit by a predetermined distance and separated from the extracting object and the vibrating unit, and transmitting an ultrasonic wave generated from the vibrating unit to the extracting object; And Extracting method of the ginseng active ingredient, characterized in that it comprises an ultrasonic delivery material filled in the space in the transmission plate including the vibration. Ginseng medicine containing an active ingredient extracted by the ultrasonic extraction method according to any one of claims 1 to 5.

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