CN115569240A - Medicine coating plastic capsule and preparation method thereof - Google Patents

Medicine coating plastic capsule and preparation method thereof Download PDF

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Publication number
CN115569240A
CN115569240A CN202211123005.4A CN202211123005A CN115569240A CN 115569240 A CN115569240 A CN 115569240A CN 202211123005 A CN202211123005 A CN 202211123005A CN 115569240 A CN115569240 A CN 115569240A
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China
Prior art keywords
coating
plastic bag
solvent
traditional chinese
chinese medicine
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CN202211123005.4A
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Inventor
董何彦
胡义平
丁涵滢
吴松
董鹏辉
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Liaoning Yinyi Biotechnology Co ltd
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Liaoning Yinyi Biotechnology Co ltd
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Priority to CN202211123005.4A priority Critical patent/CN115569240A/en
Publication of CN115569240A publication Critical patent/CN115569240A/en
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L29/00—Materials for catheters, medical tubing, cannulae, or endoscopes or for coating catheters
    • A61L29/14—Materials characterised by their function or physical properties, e.g. lubricating compositions
    • A61L29/16—Biologically active materials, e.g. therapeutic substances
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7028—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages
    • A61K31/7034—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin
    • A61K31/704—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin attached to a condensed carbocyclic ring system, e.g. sennosides, thiocolchicosides, escin, daunorubicin
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
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    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7048—Compounds having saccharide radicals and heterocyclic rings having oxygen as a ring hetero atom, e.g. leucoglucosan, hesperidin, erythromycin, nystatin, digitoxin or digoxin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/16—Ginkgophyta, e.g. Ginkgoaceae (Ginkgo family)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/23—Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
    • A61K36/236—Ligusticum (licorice-root)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/25—Araliaceae (Ginseng family), e.g. ivy, aralia, schefflera or tetrapanax
    • A61K36/258—Panax (ginseng)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
    • A61K36/286—Carthamus (distaff thistle)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
    • A61K36/481—Astragalus (milkvetch)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/53—Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
    • A61K36/537—Salvia (sage)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/55—Protease inhibitors
    • A61K38/57—Protease inhibitors from animals; from humans
    • A61K38/58—Protease inhibitors from animals; from humans from leeches, e.g. hirudin, eglin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L29/00—Materials for catheters, medical tubing, cannulae, or endoscopes or for coating catheters
    • A61L29/005—Ingredients of undetermined constitution or reaction products thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
    • A61L2300/42—Anti-thrombotic agents, anticoagulants, anti-platelet agents

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Abstract

A plastic bag with a drug coating comprises a plastic bag and a drug coating coated on the plastic bag, wherein the drug coating is a traditional Chinese medicine coating and comprises one or two of traditional Chinese medicine extracts. When the coating component is one of the components, the content ratio is 0.5 micrograms to 100 micrograms per square millimeter of plastic capsule area. When the coating comprises two components, the mass ratio of the two components is 1 to 1. The invention adopts the traditional Chinese medicine components to prepare the coating, the coating is coated on the plastic bag and then released to the local part of the blood vessel, can exert multiple effects of anticoagulation, antiplatelet and the like, does not need to take duplex antiplatelet medicaments for a long time while dredging the blood vessel, and has small toxicity risk to the local part of the blood vessel or the nervous system. The preparation method can enhance the adhesiveness of the surface of the plastic bag to the traditional Chinese medicine components, adjust the existence state and the adhesion state of the traditional Chinese medicine coating on the surface of the plastic bag, and is beneficial to the better play of the medicine coating on the surface of the plastic bag.

Description

Medicine coating plastic capsule and preparation method thereof
Technical Field
The invention relates to a medical plastic bag and a process thereof, in particular to a drug coating plastic bag and a preparation method thereof, belonging to the field of medical instruments.
Background
The drug-coated plastic capsule is an effective treatment means for vascular stenosis or occlusive diseases, and is increasingly applied in clinic. The traditional medicine coating plastic capsules all use paclitaxel and derivatives thereof and rapamycin and derivatives thereof as active medicine ingredients of the medicine coating. The paclitaxel medicine coating and the rapamycin coating can only solve the single problem of cell hyperproliferation, but can not solve multiple problems of anticoagulation, platelet resistance, blood fat reduction, blood pressure reduction, blood vessel elasticity regulation and the like. The paclitaxel medicine coating plastic capsule and the rapamycin medicine coating plastic capsule need to take the duplex antiplatelet medicine for a long time after the treatment, thereby increasing the burden and the bleeding risk of patients. Also, paclitaxel-based drug coatings and rapamycin-based coatings present the risk of vascular local toxicity and nervous system toxicity.
Disclosure of Invention
In order to solve the technical problems, the invention provides a drug coating plastic capsule and a preparation method thereof, and the adopted technical scheme is as follows:
a medicinal coating plastic bag comprises a plastic bag and a medicinal coating coated on the plastic bag, wherein the medicinal coating is a Chinese medicinal coating comprising one or two of folium Ginkgo extract, saviae Miltiorrhizae radix extract, notoginseng radix extract, flavonoid glycoside, saponin, hirudin, ginseng radix extract, radix astragali extract, rhizoma Ligustici Chuanxiong extract, and Carthami flos extract. When the coating component is one of the components, the content ratio is 0.5 micrograms to 100 micrograms per square millimeter of plastic capsule area. When the coating comprises two components, the mass ratio of the two components is 1 to 1.
The folium Ginkgo extract is ginkgetin glycoside and terpene lactone; the terpene lactone refers to bilobalide and bilobalide.
The Saviae Miltiorrhizae radix extract refers to tanshinone, salvianolic acid, protocatechualdehyde, tanshinol, tanshinoic acid, and salvianolic acid.
The Notoginseng radix extract refers to Notoginseng radix total saponin and ginsenoside.
The rhizoma Ligustici Chuanxiong extract is ligustrazine.
The Carthami flos extract refers to Carthami flos flavone, carthami flos yellow, and Carthami flos phenol glycoside.
A preparation method of a medicine coating plastic capsule comprises the following steps:
step (1), immersing the plastic bag into a first solvent at the temperature of 0-20 ℃ for 30-240 minutes; through the steps, the surface of the plastic bag is subjected to the first solvent treatment, so that the adhesion of the surface of the plastic bag to the traditional Chinese medicine component is enhanced. The surface characteristics of the plastic capsule after solvent treatment can be adjusted by adjusting the temperature and time, which is beneficial to adjusting the adhesiveness of the traditional Chinese medicine components on the surface of the plastic capsule.
Dissolving the traditional Chinese medicine components in a first solvent, coating the solution on a plastic bag, fumigating the plastic bag in the atmosphere of the first solvent for 30-240 minutes, and then waiting for the coating to dry; through the steps, the traditional Chinese medicine components on the surface of the plastic bag are subjected to post-treatment, the existence state and the adhesion state of the traditional Chinese medicine coating on the surface of the plastic bag are adjusted, and the drug effect is exerted more efficiently.
Mixing the first solvent and the second solvent to obtain a mixed solvent, dissolving the traditional Chinese medicine components in the mixed solvent, coating the mixed solvent on a plastic bag, fumigating the plastic bag in the mixed solvent atmosphere for 30-240 minutes, and waiting for the coating to be dried; through the steps, the traditional Chinese medicine components on the surface of the plastic bag are subjected to post-treatment, the existing state and the adhesion state of the traditional Chinese medicine coating on the surface of the plastic bag are adjusted, and the drug effect is exerted more effectively.
Dissolving the traditional Chinese medicine components in the step (4) in a second solvent, coating the solution on a plastic bag, fumigating the plastic bag in the atmosphere of the second solvent for 30-240 minutes, and then waiting for the coating to dry. Through the steps, the traditional Chinese medicine components on the surface of the plastic bag are subjected to post-treatment, the existence state and the adhesion state of the traditional Chinese medicine coating on the surface of the plastic bag are adjusted, and the drug effect is exerted more efficiently.
The first solvent and the second solvent are respectively one or more of water, acetonitrile, acetic acid, isopropanol, tetrahydrofuran, ethyl acetate, chloroform, dichloromethane, ethanol, dimethyl sulfoxide, polyethylene glycol, N-dimethylformamide, acetone, N-butanol, methanol, methyl formate, diethyl ether and cyclohexane.
Compared with the prior art, the invention has the beneficial effects that: the invention is different from the traditional paclitaxel and derivatives thereof or rapamycin and derivatives thereof micromolecule chemical drug coating, uses traditional Chinese medicine components to prepare the coating, coats the coating on a plastic bag, and releases the coating to the local part of a blood vessel, so that multiple effects of anticoagulation, antiplatelet, blood fat reduction, blood pressure reduction, blood vessel elasticity regulation and the like can be exerted, the blood vessel is dredged without strengthening anticoagulation and antithrombotic, a duplex antiplatelet drug is not needed to be taken for a long time, and the toxicity risk to the local part of the blood vessel or a nervous system is small. The preparation method can enhance the adhesiveness of the surface of the plastic bag to the traditional Chinese medicine components, adjust the existence state and the adhesion state of the traditional Chinese medicine coating on the surface of the plastic bag, realize the uniform, firm and stable adhesion of the traditional Chinese medicine coating on the surface of the plastic bag, and is beneficial to the better play of the medicine coating on the surface of the plastic bag. The traditional Chinese medicine coating is implemented together with a preparation method, and the anticoagulation capability can be effectively enhanced.
Detailed Description
The technical solutions of the present invention are described clearly and completely below, and it is obvious that what is described is only one embodiment of the present invention, not all embodiments. All other embodiments, which can be obtained by a person skilled in the art without inventive step based on the embodiments of the present invention, are within the scope of protection of the present invention.
Example 1
A medicinal coating plastic bag is coated on the plastic bag, and the medicinal coating is a Chinese medicinal coating comprising one or two of folium Ginkgo extract, saviae Miltiorrhizae radix extract, notoginseng radix extract, flavonoid glycoside, saponin, hirudin, hirudo peptide, ginseng radix extract, radix astragali extract, rhizoma Ligustici Chuanxiong extract, and Carthami flos extract. When the coating component is one of the components, the content ratio is 0.5 micrograms to 100 micrograms per square millimeter of plastic bag area. When the coating comprises two components, the mass ratio of the two components is 1 to 1.
Example 2
The plastic capsule with the medicine coating is coated on the plastic capsule, the medicine coating is a traditional Chinese medicine coating, the medicine coating comprises leech peptide, and the content ratio is 0.5 microgram per square millimeter of the area of the plastic capsule.
Example 3
The plastic capsule with the drug coating is coated on the plastic capsule, the drug coating is a traditional Chinese medicine coating, the traditional Chinese medicine coating comprises hirudin, and the content ratio is 100 micrograms per square millimeter of the area of the plastic capsule.
Example 4
A plastic bag with a drug coating is characterized in that the drug coating is coated on the plastic bag, the drug coating is a paclitaxel coating, the paclitaxel coating contains paclitaxel, and the content of the paclitaxel is 3 mug-mm 2 。
Example 5
Partial thromboplastin time of the drug coating plastic capsules prepared in the examples 2, 3 and 4 is tested respectively, and the anticoagulant property of the drug coating is judged. Longer partial thromboplastin times indicate greater anticoagulant capacity. Partial thromboplastin times of the drug-coated plastic capsules prepared in example 2, example 3 and example 4 were measured to be 312 seconds, 526 seconds and 154 seconds, respectively, indicating that the anticoagulation ability of the traditional Chinese medicine-coated plastic capsules prepared in example 2 and example 3 was greatly enhanced compared with that of example 4.
Example 6
A preparation method of a medicine coating plastic capsule comprises the following steps:
soaking a plastic bag into a water solvent at the temperature of 0 ℃ for 30 minutes; through the steps, the surface of the plastic bag is subjected to hydrosolvent treatment, so that the adhesiveness of the surface of the plastic bag to the traditional Chinese medicine components is enhanced.
Dissolving the traditional Chinese medicine components in an aqueous solvent, coating the aqueous solvent on a plastic bag, fumigating the plastic bag in the aqueous solvent for 30 minutes, and then waiting for the coating to dry; through the steps, the traditional Chinese medicine components on the surface of the plastic bag are subjected to post-treatment, the existence state and the adhesion state of the traditional Chinese medicine coating on the surface of the plastic bag are adjusted, and the drug effect is exerted more efficiently.
Mixing the aqueous solvent and the acetonitrile solvent to obtain a mixed solvent, dissolving the traditional Chinese medicine components in the mixed solvent, coating the mixed solvent on a plastic bag, fumigating the plastic bag in the mixed solvent atmosphere for 30 minutes, and then waiting for the coating to dry; through the steps, the traditional Chinese medicine components on the surface of the plastic bag are subjected to post-treatment, the existence state and the adhesion state of the traditional Chinese medicine coating on the surface of the plastic bag are adjusted, and the drug effect is exerted more efficiently.
And (4) dissolving the traditional Chinese medicine components in the acetonitrile solvent, coating the acetonitrile solvent onto the plastic bag, fumigating the plastic bag in the acetonitrile solvent atmosphere for 30 minutes, and waiting for the coating to dry. Through the steps, the traditional Chinese medicine components on the surface of the plastic bag are subjected to post-treatment, the existence state and the adhesion state of the traditional Chinese medicine coating on the surface of the plastic bag are adjusted, and the drug effect is exerted more efficiently.
Example 7
A preparation method of a drug-coated plastic capsule comprises the following steps:
step (1), immersing the plastic bag into an ethanol solvent at 10 ℃ for 120 minutes; the surface of the plastic bag is treated by ethanol solvent, so that the adhesiveness of the surface of the plastic bag to the traditional Chinese medicine components is enhanced.
Dissolving the traditional Chinese medicine components in an ethanol solvent, coating the ethanol solvent on a plastic bag, fumigating the plastic bag in the ethanol solvent atmosphere for 120 minutes, and then waiting for the coating to dry; through the steps, the traditional Chinese medicine components on the surface of the plastic bag are subjected to post-treatment, the existence state and the adhesion state of the traditional Chinese medicine coating on the surface of the plastic bag are adjusted, and the drug effect is exerted more efficiently.
Step (3) taking an ethanol solvent as a mixed solvent, dissolving the traditional Chinese medicine components in the mixed solvent, coating the mixed solvent on a plastic bag, fumigating the plastic bag in the mixed solvent atmosphere for 120 minutes, and then waiting for the coating to dry; through the steps, the traditional Chinese medicine components on the surface of the plastic bag are subjected to post-treatment, the existence state and the adhesion state of the traditional Chinese medicine coating on the surface of the plastic bag are adjusted, and the drug effect is exerted more efficiently.
And (5) dissolving the traditional Chinese medicine components in the ethanol solvent, coating the ethanol solvent onto the plastic bag, fumigating the plastic bag in the ethanol solvent atmosphere for 120 minutes, and then waiting for the coating to dry. Through the steps, the traditional Chinese medicine components on the surface of the plastic bag are subjected to post-treatment, the existence state and the adhesion state of the traditional Chinese medicine coating on the surface of the plastic bag are adjusted, and the drug effect is exerted more efficiently.
Example 8
A preparation method of a drug-coated plastic capsule comprises the following steps:
step (1), immersing the plastic capsule into an ether solvent at the temperature of 20 ℃ for 240 minutes; the surface of the plastic capsule is treated by ether solvent to enhance the adhesiveness of the surface of the plastic capsule to the traditional Chinese medicine.
Dissolving the traditional Chinese medicine components in an ether solvent, coating the solution on a plastic bag, fumigating the plastic bag in the ether solvent for 240 minutes, and then waiting for the coating to dry; through the steps, the traditional Chinese medicine components on the surface of the plastic bag are subjected to post-treatment, the existing state and the adhesion state of the traditional Chinese medicine coating on the surface of the plastic bag are adjusted, and the drug effect is exerted more effectively.
Mixing an ether solvent and a cyclohexane solvent to obtain a mixed solvent, dissolving the traditional Chinese medicine components in the mixed solvent, coating the mixed solvent on a plastic bag, fumigating the plastic bag in the mixed solvent atmosphere for 240 minutes, and then waiting for the coating to dry; through the steps, the traditional Chinese medicine components on the surface of the plastic bag are subjected to post-treatment, the existing state and the adhesion state of the traditional Chinese medicine coating on the surface of the plastic bag are adjusted, and the drug effect is exerted more effectively.
And (5) dissolving the traditional Chinese medicine components in the cyclohexane solvent, coating the solution on a plastic bag, fumigating the plastic bag in the cyclohexane solvent atmosphere for 240 minutes, and then waiting for the coating to dry. Through the steps, the traditional Chinese medicine components on the surface of the plastic bag are subjected to post-treatment, the existing state and the adhesion state of the traditional Chinese medicine coating on the surface of the plastic bag are adjusted, and the drug effect is exerted more effectively.
Example 9
A medicine coating plastic capsule, the medicine coating coats on plastic capsule, the medicine coating is a Chinese medicine coating, its ingredient is extract of folium Ginkgo and radix Salviae Miltiorrhizae extract, the mass ratio between two kinds of ingredients is 1, the total content is 50 microgram per square millimeter of plastic capsule area.
Example 10
A medicine coating plastic bag, the medicine coating is coated on the plastic bag, the medicine coating is a traditional Chinese medicine coating, the medicine coating comprises notoginseng extract and flavonoid glycoside extract, the mass ratio of the two components is 1.
Example 11
A medicine coating plastic capsule, the medicine coating is coated on the plastic capsule, the medicine coating is a traditional Chinese medicine coating, the medicine coating comprises the components of ligusticum wallichii extract and safflower extract, the mass ratio of the two components is 1.
The above description is only for the purpose of illustrating the preferred embodiments of the present invention and is not to be construed as limiting the invention, and any modifications, equivalents, improvements and the like that fall within the spirit and principle of the present invention are intended to be included therein.

Claims (8)

1. A medicine coating plastic bag comprises a plastic bag and a medicine coating coated on the plastic bag, and is characterized in that the medicine coating is a traditional Chinese medicine coating, and the medicine coating comprises one or two of ginkgo leaf extract, salvia miltiorrhiza extract, panax notoginseng extract, flavonoid glycoside, saponin, hirudin, leech peptide, ginseng extract, astragalus extract, ligusticum wallichii extract and safflower extract; when the coating component is one of the components, the content ratio is 0.5 micrograms to 100 micrograms per square millimeter of plastic capsule area; when the coating comprises two components, the mass ratio of the two components is 1 to 1.
2. The drug-coated plastic pouch of claim 1, wherein the ginkgo biloba extract is ginkgetin glycoside, terpene lactone; the terpene lactone refers to bilobalide and bilobalide.
3. The drug-coated plastic capsule of claim 1, wherein the radix salviae miltiorrhizae extract is tanshinone, salvianolic acid, protocatechuic aldehyde, tanshinol, danshenic acid, or salvianolate.
4. The plastic capsule as claimed in claim 1, wherein the Panax notoginseng extract is selected from Panax notoginseng saponins and ginsenoside.
5. The drug-coated plastic capsule of claim 1, wherein said chuanxiong rhizome extract is ligustrazine.
6. The drug-coated plastic capsule of claim 1, wherein the safflower extract is safflower flavone, safflower yellow, safflower phenolic glycoside.
7. A preparation method of a medicine coating plastic capsule is characterized by comprising the following steps:
step (1) immersing the plastic capsule in a first solvent at a temperature of 0-20 ℃ for 30-240 minutes;
dissolving the traditional Chinese medicine components in a first solvent, coating the solution on a plastic bag, fumigating the plastic bag in the first solvent for 30-240 minutes, and waiting for the coating to dry;
mixing the first solvent and the second solvent to obtain a mixed solvent, dissolving the traditional Chinese medicine components in the mixed solvent, coating the mixed solvent on a plastic bag, fumigating the plastic bag in the mixed solvent atmosphere for 30-240 minutes, and then waiting for the coating to dry;
dissolving the traditional Chinese medicine ingredients in the step (4) in a second solvent, coating the solution on a plastic bag, fumigating the plastic bag in the atmosphere of the second solvent for 30-240 minutes, and then waiting for the coating to dry.
8. The method for preparing a drug-coated plastic capsule according to claim 7, wherein the first solvent and the second solvent are one or more of water, acetonitrile, acetic acid, isopropanol, tetrahydrofuran, ethyl acetate, chloroform, dichloromethane, ethanol, dimethyl sulfoxide, polyethylene glycol, N-dimethylformamide, acetone, N-butanol, methanol, methyl formate, diethyl ether and cyclohexane.
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