CN109700895A - A kind of Chinese medicine composition for medical catheter - Google Patents
A kind of Chinese medicine composition for medical catheter Download PDFInfo
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- CN109700895A CN109700895A CN201910165514.5A CN201910165514A CN109700895A CN 109700895 A CN109700895 A CN 109700895A CN 201910165514 A CN201910165514 A CN 201910165514A CN 109700895 A CN109700895 A CN 109700895A
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Abstract
The present invention relates to the field of Chinese medicines, and in particular to a kind of Chinese medicine composition for medical catheter.A kind of Chinese medicine composition for medical catheter, including Magnolia cortex P.E, Japanese beauty-berry, Folium Isatidis extract, Baical Skullcap root P.E.Chinese medicine composition of the present invention for medical catheter has antibacterial bacteriostatic, hemostasis and anti-inflammation, the effect of calm analgesic, it is applied on prostate dilator, compared with conduit currently on the market, conduit not only can guarantee that effect is split in expansion, also act as the effect of hemostasis by compression, the compressing to external sphincter is released, it will not excessive damage external sphincter, the prevention urinary incontinence and big bleeding；In addition, conduit of the present invention can effectively avoid the addition because of foreign material, solidify blood in art, generate the harm of thrombus, and the franchise of size after water pocket free wxpansion and under natural conditions is little, so that the pain of patient be made to mitigate in the course of surgery.
Description
Technical field
The invention belongs to the field of Chinese medicines, more particularly it relates to a kind of Chinese medicine composition for medical catheter.
Background technique
Hyperplasia of prostate is the common disease of middle-aging male, so-called hyperplasia of prostate, mainly due to prostata tissue
Hyperplasia, cause its volume increase, and then squeeze around organ, cause urinary tract to become smaller and narrow, thus occur dysuria, urine
Frequently, the symptoms such as urination time length.Traditional therapeutic modality be prostata tissue is cut, but perform the operation to patient strike compared with
Greatly, and old human body and poor to the ability to bear of operation at heart, it is unwilling to undergo surgery.Treatment side more advanced at present
Formula is that prostate expands operation, and this treatment operation is by the way that prostate dilator is inserted into patient's prostatic urethra, benefit
It is treated with the full mode of sacculus water filling, this operation wound is small, and operating time is short, and safety coefficient is high, is that prostate is suffered from
The optimal selection of person.
But a large amount of blood can be speckled with after the generally existing prostate dilator use of prostate dilator at present, and
Patient after use is easy to appear thrombus；In addition, in practical applications, the water pocket of some prostate dilators occurs freely swollen
Size and franchise difference after swollen and under natural conditions is larger, to easily occur excessive prostate tearing or forefront during surgery
Gland tear(ing) strength is inadequate, not only makes the effect decline of operation, it is also possible to cause urine because non-prostatic urethra is excessively expanded
Control damage and urethral injury.
Summary of the invention
To solve the above-mentioned problems, first aspect of the present invention provides a kind of Chinese medicine composition for medical catheter,
Including Magnolia cortex P.E, Japanese beauty-berry, Folium Isatidis extract, Baical Skullcap root P.E.
As a kind of perferred technical scheme, the Magnolia cortex P.E, Japanese beauty-berry, Folium Isatidis extract, radix scutellariae mention
The weight ratio for taking object is (2-3): (1-2): (2-3): 1.
The second aspect of the present invention provides a kind of medical catheter, the coating containing above-mentioned Chinese medicine composition.
Third aspect of the present invention provides a kind of preparation method of medical catheter, and step includes:
(1) according to weight ratio, Chinese medicine composition and solvent are mixed；
(2) mesoporous silicon oxide is added in step (1), mixing 10-15 hours is then stirred under ultrasonic agitation；
(3) under static conditions, into the mixed system of step (2) by solvent volume ratio be 1:(2-5) amount addition go from
Sub- water, after standing 20-30 hours, mesoporous silicon oxide is taken out in filtering；
(4) after the mesoporous silicon oxide being obtained by filtration in step (3) being washed with deionized 3-4 times, deionization is added
In, it is weighed in coupling agent kh550 addition system by the amount of silica weight ratio 1.0%-2.5%, ball milling mixing uniformly obtains
Mixture, ball milling 0.5-1h, obtains improved silica；
(5) improved silica and acrylic emulsion that step (4) obtains are stirred, obtain mixed solution；It will mix
It closes solution to be coated on medical catheter, the medical catheter of the coating coated with Chinese medicine composition can be prepared after drying.
As a kind of perferred technical scheme, the weight ratio of solvent and Chinese medicine composition is (2.5- in the step (1)
3.5): 1；It is (70-80) that the solvent, which is according to the volume ratio of ethyl alcohol and n-butanol: (20-30) compounds obtained mixed solvent.
As a kind of perferred technical scheme, the partial size of step (2) the intermediary hole silica is 90 ± 20nm, mesoporous
Aperture is 1-10nm, pore volume > 0.5cm3/ g, specific surface area are > 500m2/g。
As a kind of perferred technical scheme, the weight ratio of step (2) the intermediary hole silica and Chinese medicine composition
For 1:(4-5).
As a kind of perferred technical scheme, the weight of step (4) the intermediary hole silica and the deionized water of addition
Amount is than being 1:(1.1-1.3).
As a kind of perferred technical scheme, in the step (5) improved silica and acrylic emulsion weight ratio
For 1:(0.6-1.3).
As a kind of perferred technical scheme, main pipe's material of medical catheter is TPU or PVC in the step (5)；Institute
It states and is additionally provided with preceding capsule and rear capsule on conduit, and the material of the preceding capsule and rear capsule is TPU or natural emulsion.
The utility model has the advantages that the Chinese medicine composition of the present invention for medical catheter has antibacterial bacteriostatic, hemostasis and anti-inflammation, town
Surely the effect relieved pain is applied on prostate dilator, and compared with conduit currently on the market, conduit can not only be protected
Card, which expands, splits effect, also acts as the effect of hemostasis by compression, releases the compressing to external sphincter, will not excessive damage external sphincter, in advance
The anti-urinary incontinence and big bleeding；In addition, conduit of the present invention can effectively avoid the addition because of foreign material, make blood in art
Solidification, generates the harm of thrombus, and the franchise of size after water pocket free wxpansion and under natural conditions is little, thus performing the operation
Mitigate the pain of patient in journey.
Detailed description of the invention
It, below will be to specific in order to illustrate more clearly of the specific embodiment of the invention or technical solution in the prior art
Embodiment or attached drawing needed to be used in the description of the prior art be briefly described, it should be apparent that, it is described below
Attached drawing is some embodiments of the present invention, for those of ordinary skill in the art, before not making the creative labor
It puts, is also possible to obtain other drawings based on these drawings.
Fig. 1: guide-tube structure schematic diagram
Fig. 2: conduit Section A-A cross-sectional view
The corresponding relationship of appended drawing reference and component of the present invention in Fig. 1, Fig. 2 are as follows:
1, seal wire, 2, flared joint, 3, main pipe, 4, filling liquid pipe, 5, flushing end connector, 6, convex, 7, rear capsule, 8,
Preceding capsule, 9, switch folder, 10, female Luer, 11, triple valve, 12, water injection pipe, 13, urethral catheterization chamber, 14, rear high pressure water blister cavities, 15, punching
Wash chamber, 16, preceding high pressure water blister cavities.
Specific embodiment
It is further clear, complete that the technical characteristic work in technical solution is provided to the present invention With reference to embodiment
Description, not to the limitation of its protection scope.
Word " preferred ", " preferred " in the present invention etc. refer to, can provide in some cases certain beneficial to effect
The embodiment of the present invention of fruit.However, other embodiments are also likely to be preferred under identical circumstances or in the case of other
's.In addition, do not imply that other embodiments are unavailable to the statement of one or more preferred embodiments, be also not intended to by
Other embodiments exclude except the scope of the present invention.
To solve the above-mentioned problems, first aspect of the present invention provides a kind of Chinese medicine composition for medical catheter,
Including Magnolia cortex P.E, Japanese beauty-berry, Folium Isatidis extract, Baical Skullcap root P.E.
As a kind of perferred technical scheme, the Magnolia cortex P.E, Japanese beauty-berry, Folium Isatidis extract, radix scutellariae mention
The weight ratio for taking object is (2-3): (1-2): (2-3): 1.
As a kind of preferred embodiment, the Magnolia cortex P.E, Japanese beauty-berry, Folium Isatidis extract, radix scutellariae
The ratio of extract is 2.5:1.5:2.5:1.
Magnolia cortex P.E
Cortex Magnoliae Officinalis (scientific name: Magnolia officinalis Rehd.et Wils.) extract source lily magnolia of the present invention
Section's plant Cortex Magnoliae Officinalis, the purple Piao of alias, purple oil Piao, warm Piao etc. within the scope of Cortex Magnoliae Officinalis botany are Magnoliaceae, magnolia, common to be
Cortex Magnoliae Officinalis.Effective component: honokiol, magnolol, magnolia bark total-phenol.Plant origin: Cortex Magnoliae Officinalis (Magnolia officinalis
Rehder et Wilson) effective component of antibacterial action in skin.For off-white powder crystallization, there is special, lasting flesh
Meat relexation and strong antibacterial action, can inhibit platelet aggregation.
Magnolia cortex P.E of the present invention is bought from Guangzhou Jingjing Biotechnology Co., Ltd.
Japanese beauty-berry
Callicarpa bodinieri Levl. (scientific name: Callicarpa bodinieri Levl.) extract source Verenaceae, purple of the present invention
Main component: pearl category machaka leaf contains amino acid, phenols, reducing substances, glycoside, condensed tannin, flavones and lactone.
The still microelements containing resinene, carbohydrate, hydroxy compounds and magnesium, calcium, iron etc..It can make local vasoconstriction, when shortening blood coagulation
Between and prothrombin time, effect is significantly inhibited to fibrinolytic system.
Japanese beauty-berry of the present invention is bought from Xi'an Bioisystech Co., Ltd, Tianrui.
Folium Isatidis extract
Of the present invention is brown (green) color powder, and taste is slightly sour, bitter, puckery, has and draws moist, effective component: indigo red, to golden yellow
Color staphylococcus, alpha streptococcus, diplococcus meningitidis, streptococcus pneumonia, micrococcus catarrhalis, typhoid bacillus, Escherichia coli, influenza
Bacillus, corynebacterium diphtheriae and shigella dysenteriae have certain inhibiting effect, to japanese encephalitis virus, mumps virus, influenza disease
Poison etc. also has inhibiting effect, has apparent inhibiting effect to inflammatory reaction caused by a variety of proinflammatory agents.
Folium Isatidis extract of the present invention is bought from Xi'an Qing Zhi Bioisystech Co., Ltd.
Baical Skullcap root P.E
Baical Skullcap root P.E of the present invention is flaxen powder made from the extracted drying of scutellaria；Gas is micro-, bitter.Including
There are scutelloside (baicalin), wogonoside (wogonoside), baicalein (baicalein) and wogonin (wogonin)
Deng.With extensive pharmacological action, such as anti-inflammatory, anti-oxidant, antitumor and immunological regulation, especially most with antibacterium/fungi effect
It is significant.
Baical Skullcap root P.E of the present invention is bought from Changsha Rui Ding Biotechnology Co., Ltd.
The second aspect of the present invention provides a kind of medical catheter, the coating containing above-mentioned Chinese medicine composition.
Fig. 1 is the structural schematic diagram of conduit of the present invention；Fig. 2 is conduit Section A-A cross-sectional view.
Preferably, as shown in Figure 2: chamber there are four setting on the conduit, respectively urethral catheterization chamber 13 rinse chamber 15, preceding high pressure
Water pocket chamber 16, rear high pressure water blister cavities 14.
Preferably, as shown in Figure 1 and Figure 2: preceding capsule 8, rear capsule 7, convex 6, preceding 8 He of capsule are additionally provided on the conduit
Capsule 7 is coated on the conduit main pipe 3 afterwards, and the preceding capsule 8 is located at the front end of the rear capsule 7, and the convex 6 is located at described
The tail end rear portion of capsule 7 afterwards；The preceding high pressure water blister cavities 16, rear high pressure water blister cavities 14 front end be opened on respectively the preceding capsule 8, after
In capsule 7.
It is further preferred that 3 end of main pipe is connected with flared joint 2, seal wire 1 is socketed on the inside of it, it is main
3 bottom of tube body be fixed with rinse chamber 15, preceding high pressure water blister cavities 16, rear high pressure water blister cavities 14 water injection pipe 12 on have switch folder 9 and
Female Luer 10 is socketed with triple valve 11 on the inside of female Luer 10.
In a preferred embodiment, the preceding capsule 8 passes through the triple valve 11 of preceding high pressure water blister cavities 16 blister cavities forward
In carry out water filling pressurization, it is described after capsule 7 by carrying out water filling pressurization in the triple valve 11 of rear high pressure water blister cavities 14 backward blister cavities.
In a preferred embodiment, for expanding membranous urethra and apex of prostate after 7 pressurized expansion of the rear capsule
Portion, for expanding prostatic part and bladder neck after preceding 8 pressurized expansion of capsule.
In a preferred embodiment, the convex 6 can touch in use.
In a preferred embodiment, the entrance for rinsing chamber 15 and rinsing chamber 15 by a connection of flushing pipe 4
It is exported with chamber is rinsed, the entrance and exit of the urethral catheterization chamber 13 directly penetrates through entire conduit.
In a preferred embodiment, above-mentioned Chinese medicine composition is coated on the conduit.
Third aspect of the present invention provides a kind of preparation method of medical catheter, and step includes:
(1) according to weight ratio, Chinese medicine composition and solvent are mixed；
(2) mesoporous silicon oxide is added in step (1), mixing 10-15 hours is then stirred under ultrasonic agitation；
(3) under static conditions, into the mixed system of step (2) by solvent volume ratio be 1:(2-5) amount addition go from
Sub- water, after standing 20-30 hours, mesoporous silicon oxide is taken out in filtering；
(4) after the mesoporous silicon oxide being obtained by filtration in step (3) being washed with deionized 3-4 times, deionization is added
In, it is weighed in coupling agent kh550 addition system by the amount of silica weight ratio 1.0%-2.5%, ball milling mixing uniformly obtains
Mixture, ball milling 0.5-1h, obtains improved silica；
(5) improved silica and acrylic emulsion that step (4) obtains are stirred, obtain mixed solution；It will mix
It closes solution to be coated on medical catheter, the medical catheter of the coating coated with Chinese medicine composition can be prepared after drying.
In a preferred embodiment, the weight ratio of solvent and Chinese medicine composition is (2.5- in the step (1)
3.5): 1；It is (70-80) that the solvent, which is according to the volume ratio of ethyl alcohol and n-butanol: (20-30) compounds obtained mixed solvent.
In a kind of preferred embodiment, the partial size of step (2) the intermediary hole silica is 90 ± 20nm, is situated between
Hole aperture is 1-10nm, pore volume > 0.5cm3/ g, specific surface area are > 500m2/g。
In a kind of preferred embodiment, the weight of step (2) the intermediary hole silica and Chinese medicine composition
Than for 1:(4-5).
The present invention selects specific mesoporous silicon oxide, traditional Chinese medicine ingredients is stably fixed in silica, while blood
It can be contacted again with traditional Chinese medicine ingredients, it, in this way can be residual to avoid traditional Chinese medicine ingredients so as to play the role of anti-inflammatory, hemostasis, analgesic
It stays in and forms allergic reaction in human body.
In a preferred embodiment, the weight of step (4) the intermediary hole silica and the deionized water of addition
Amount is than being 1:(1.1-1.3).
In a kind of preferred embodiment, the weight of improved silica and acrylic emulsion in the step (5)
Than for 1:(0.6-1.3).
In a kind of preferred embodiment, main pipe's material of medical catheter is TPU or PVC in the step (5).
Preceding capsule and rear capsule are additionally provided on the conduit, and the material of the preceding capsule and rear capsule is TPU or natural emulsion.
Still more preferably, a kind of preparation method of medical catheter, step include:
(1) according to the weight ratio (2.5-3.5) of solvent and Chinese medicine composition: 1, Chinese medicine composition and solvent are mixed；Its
In, it is (70-80) that the solvent, which is according to the volume ratio of ethyl alcohol and n-butanol: (20-30) compounds obtained mixed solvent；It is described
It is (2-3) that Chinese medicine composition, which is according to the weight ratio of Magnolia cortex P.E, Japanese beauty-berry, Folium Isatidis extract, Baical Skullcap root P.E:
(1-2): (2-3): the mixture that 1 compounding obtains；
(2) mesoporous silicon oxide is added in step (1), mixing 10-15 hours is then stirred under ultrasonic agitation,
Wherein, the weight ratio of the mesoporous silicon oxide and Chinese medicine composition is 1:(4-5)；The partial size of the mesoporous silicon oxide is 90
± 15nm, mesoporous pore size 3-4nm, pore volume > 0.5cm3/ g, specific surface area are > 500m2/g；
(3) under static conditions, into the mixed system of step (2) by solvent volume ratio be 1:(2-5) amount addition go from
Sub- water, after standing 20-30 hours, mesoporous silicon oxide is taken out in filtering；
(4) after the mesoporous silicon oxide being obtained by filtration in step (3) being washed with deionized 3-4 times, by mesoporous dioxy
The weight ratio of SiClx and the deionized water of addition is 1:(1.1-1.3) deionized water is added, by silica weight ratio 1.0%-
2.5% amount weighs in coupling agent kh550 addition system, and ball milling mixing uniformly obtains mixture, and ball milling 0.5-1h is modified
Silica；
(5) improved silica and acrylic emulsion that step (4) obtains are stirred, obtain mixed solution；It will mix
It closes solution to be coated on medical catheter, the medical catheter of the coating coated with Chinese medicine composition can be prepared after drying；Its
In, the weight ratio of improved silica and acrylic emulsion is 1:(0.6-1.3)；Main pipe's material of the medical catheter is
TPU or PVC.Preceding capsule and rear capsule are additionally provided on the conduit, and the material of the preceding capsule and rear capsule is TPU or natural emulsion.
The partial size of mesoporous silicon oxide of the present invention is 90 ± 15nm, mesoporous pore size 3-4nm, pore volume > 0.5cm3/
G, specific surface area are > 500m2/ g is bought from Shanghai Suo Fei biological medicine Science and Technology Ltd..
Acrylic emulsions of the present invention are medical type acrylic emulsion, and brand is Jin nation peak, model 0722.
Kh550 of the present invention is amido functional group silane, and chemical name is gamma-aminopropyl-triethoxy-silane.
PVC of the present invention is polyvinyl chloride, it is one of maximum plastic product of yield in the world, cheap, is answered
With extensive, suitable plasticizer is added in Corvic, can be made into a variety of hard, soft and transparent article.
TPU of the present invention is that the polymer in macromolecular main chain containing carbamate groups is known as polyurethane
Ester, abbreviation TPU.TPU points are polyester polyurethane and polyether polyurethane two major classes.Polyester-type is with diisocyanate and end hydroxyl
Base polyester is the polyurethane of raw material preparation.Polyether polyurethane is gathered using diisocyanate and end hydroxy polyether as prepared by raw material
Urethane.
In a preferred embodiment, the TPU material is super branched polyurethane material.
In a kind of preferred embodiment, it is super that the super branched polyurethane is that sulfonic group and/or carboxylic acid group block
Branched polyurethanes.
Still more preferably, the super branched polyurethane is the super branched polyurethane of carboxylic acid group's sealing end.
In a preferred embodiment, the super branched polyurethane of the sulfonic group and/or carboxylic acid group's sealing end is by polymerizeing
Monomer 2,3,4 is blocked using sulfonic group and/or carboxylic acid group after reacting with hyper-branched polyester (HBPs) and is prepared.
In a preferred embodiment, the hyper-branched polyester (HBPs) is prepared by the following method: being equipped with
In the three-necked flask of mechanical stirring, thermometer and spherical reflux condensing tube, ethylene glycol, N, bis- (2- hydroxyethyl) piperazines of N'- are added
DBTDL is added in piperazine and trimellitic anhydride, and under nitrogen protection, in 40 DEG C of pre-polymerization 8h, then heating is heated to 100 DEG C, vacuumizes
10h is reacted, until system acid value is lower than 30mgKOH/g, cooling obtains colorless and transparent solid, i.e. hyper-branched polyester (HBPs)；
Wherein, No. CAS of bis- (2- hydroxyethyl) piperazines of the N, N'- is 122-96-3；The DBTDL is tin dilaurate
Dibutyl tin, No. CAS is 77-58-7；The ethylene glycol, N, the molar ratio of bis- (2- hydroxyethyl) piperazines of N'-, trimellitic anhydride
For 4:2:3；The additional amount of the DBTDL is the 0.3% of total monomer weight.
In a preferred embodiment, the polymerized monomer 2 is prepared by the following method: protecting in nitrogen atmosphere
Under, IPDI and n,N-Dimethylformamide (DMF) are added into four-hole bottle, stirring shakes up, later by MPEG-1000, DBTDL with
And p-hydroxyanisole is dissolved into DMF, pours into dropping funel, and mixed liquor is slowly dropped in the four-hole bottle that stirred, oil
Bath control temperature keeps the temperature 3-4h, is titrated by di-n-butylamine and determine reaction end, obtain polymerized monomer 2 at 30 DEG C；
Wherein, the IPDI is isophorone diisocyanate, and No. CAS is 4098-71-9；The MPEG-1000 is poly-
Glycol monoethyl ether MPEG is bought from Nantong MICHAEL DRAKE Chemical Co., Ltd.；The DBTDL is dibutyl tin dilaurate, CAS
Number be 77-58-7；The molar ratio of described IPDI, MPEG-1000 are 1:1；The additional amount of the DBTDL is total monomer weight
0.1%；The concentration of the p-hydroxyanisole is 1000ppm.
In a preferred embodiment, the polymerized monomer 3 is prepared by the following method: protecting in nitrogen atmosphere
Under, trimethyl -1 is added into four-hole bottle, hexamethylene-diisocyanate and n,N-Dimethylformamide (DMF) stirring shake up, later
By 2- [2- (2- methoxy ethoxy) ethyoxyl]-ethyl alcohol, DBTDL and p-hydroxyanisole are dissolved into DMF, pour into dropping liquid
Mixed liquor is slowly dropped in the four-hole bottle that stirred by funnel, and oil bath controls temperature at 28 DEG C, keeps the temperature 3-4h, just by two
Butylamine, which titrates, determines reaction end, obtains polymerized monomer 3；
Wherein, the trimethyl -1, No. CAS of hexamethylene-diisocyanate are 15646-96-5；2- [2- (the 2- methoxy
Base oxethyl) ethyoxyl] No. CAS of-ethyl alcohol be 112-35-6；The DBTDL is dibutyl tin dilaurate, and No. CAS is 77-
58-7；Trimethyl-the hexamethylene diisocyanate, 2- [2- (2- methoxy ethoxy) ethyoxyl]-ethyl alcohol molar ratio be
1:1；The additional amount of the DBTDL is the 0.1% of total monomer weight；The concentration of the p-hydroxyanisole is 1000ppm.
In a preferred embodiment, the polymerized monomer 4 is prepared by the following method: protecting in nitrogen atmosphere
Under, 2,4- dioxo -1,3-, bis- azetidine -1,3-, bis- (hexa-methylene) diisocyanate and N, N- diformazan are added into four-hole bottle
Base formamide stirring shake up, later by fluoro- 4, the 6- dihydroxy-pyrimidine of 5- and the fluoro- 5- (hydroxyl of (1S, 2S, 3S, 5S) -3- amino -2-
Ylmethyl) cyclopentanol, DBTDL and p-hydroxyanisole are dissolved into DMF, pour into dropping funel, mixed liquor is slowly added dropwise
Into the four-hole bottle that stirred, oil bath controls temperature at 35 DEG C, keeps the temperature 3-4h, is titrated by di-n-butylamine and determines reaction end,
Obtain polymerized monomer 4；
Wherein, No. CAS of 2,4- dioxo -1,3- bis- azetidine -1,3- bis- (hexa-methylene) diisocyanate is
23501-81-7；No. CAS of the fluoro- 4,6- dihydroxy-pyrimidine of 5- is 106615-61-6；(1S, 2S, 3S, the 5S) -3- ammonia
No. CAS of base -2- fluoro- 5- (hydroxymethyl) cyclopentanol is 110289-08-2；Two azetidine -1 2,4- dioxo -1,3-,
3- bis- (hexa-methylene) diisocyanate, the fluoro- 4,6- dihydroxy-pyrimidine of 5-, the fluoro- 5- (hydroxyl of (1S, 2S, 3S, 5S) -3- amino -2-
Ylmethyl) cyclopentanol molar ratio be 3:2:4；The additional amount of the DBTDL is the 0.15% of total monomer weight；It is described to hydroxyl
The concentration of methyl phenyl ethers anisole is 1800ppm.
In a preferred embodiment, the super branched polyurethane is by polymerized monomer 2,3,4 and hyper-branched polyester
(HBPs) it being prepared, step includes: that the polymerized monomer 2,3,4 and hyper-branched polyester (HBPs) are added in there-necked flask, it
After DMF is added, mixing shakes up, temperature be 70 DEG C, nitrogen protection is flowed back under stirring with condenser pipe, keep the temperature 5h after be vigorously stirred, instead
After answering completely, obtained product is evaporated into solvent DMF by rotary evaporator at 55 DEG C of vacuum, it is thick to obtain super branched polyurethane
Product；
Wherein, the polymerized monomer 2,3,4 and the molar ratio of hyper-branched polyester (HBPs) are (1-1.5): (1-1.5): (1-
1.5): 1.
In a preferred embodiment, the following institute of preparation step of the super branched polyurethane of carboxylic acid group's sealing end
It states: p-methyl benzenesulfonic acid being added in the super branched polyurethane system of previous step preparation, then succinic anhydride is dissolved in N, N- diformazan
It in yl acetamide, is then slowly dropped in above-mentioned system, stirs, dripped in 0.5h, then in 80-90 when being added dropwise
3-4h is reacted at DEG C, the solvent being then evaporated under reduced pressure in removing system obtains the super branched polyurethane of carboxylic acid group's sealing end；
Wherein, the weight ratio of the p-methyl benzenesulfonic acid and super branched polyurethane is 1:(30-50)；The succinic anhydride and super
The molar ratio of branched polymer is (2-4): 1.
The super branched polyurethane for the sealing end that present inventor's discovery is prepared using the present invention is avoided that patient occurs
Situations such as thrombus, is blocked with sulfonic group/carboxylic acid group, and contains macrophage in blood, and the macrophage can generate oxygen
Free radical has certain redox ability, therefore the surface of super branched polyurethane can produce under the action of macrophage
Raw negative electrical charge.The measurement of cell electrophoresis shows that red blood cell, leucocyte and platelet surface all have negative electrical charge.Therefore meeting and gather
Urethane surface generates and bears mutually exclusive effect, will not be due to absorption, and material surface quickly forms protein adsorption layer, therefore leads
Cause thrombosis；But present invention selection specifically prepares monomer, its surface of the super branched polyurethane being prepared is because huge
Negative electrical charge is presented in the effect of phagocyte, but the micro phase separation structure of the super branched polyurethane is in electropositive, so as to keep away
Exempt to activate clotting of plasma program due to electronegativity；Using this effect mutually forced to do one's bidding between positive negativity, so that using this warp
, hardly there is situations such as allergy, thrombus in the patient of urethra prostate dilator.
Present inventor has found to use in the course of the study super branched polyurethane of the surface with sulfonic acid group can be with
Situations such as avoiding the occurrence of thrombus, but sulfonic acid group can be with the positive charge group inside branched polyurethanes because of polarity and positive negative electricity
Negativity so that between generate physical crosslinking connection, to generate more crystalline states, occur after free wxpansion and under natural conditions
Size and franchise difference it is larger, to easily occur excessive prostate tearing or prostate tearing journey in actual use operation
Degree not enough, it is unobvious to cause postoperative effect；Easily or the urethra of formation is unsmooth, so that patient is again by pain.Therefore, originally
Application preferably using carboxylic acid group sealing end super branched polyurethane, and using carboxylic acid group sealing end after, the docile property of centering medicine coating is more
It is good, it is that can stablize docile due to suitable polarity between carboxylic acid group and acrylic acid.
The present invention is specifically described below by embodiment, in addition, if without other explanations, it is raw materials used to be all
It is commercially available.
Embodiment
Embodiment 1
Embodiment 1 provides a kind of preparation method of medical catheter, and step includes:
(1) according to the weight ratio 3:1 of solvent and Chinese medicine composition, Chinese medicine composition and solvent are mixed；Wherein, described molten
It is mixed solvent that 75:22 is compounded that agent, which is according to the volume ratio of ethyl alcohol and n-butanol,；The Chinese medicine composition is according to thickness
Plain extract, Japanese beauty-berry, Folium Isatidis extract, Baical Skullcap root P.E weight ratio be that 2.5:1.5:2.5:1 is compounded
Mixture；
(2) mesoporous silicon oxide is added in step (1), mixing 12 hours is then stirred under ultrasonic agitation,
In, the weight ratio of the mesoporous silicon oxide and Chinese medicine composition is 1:4.5；The partial size of the mesoporous silicon oxide be 90 ±
15nm, mesoporous pore size 3-4nm, pore volume > 0.5cm3/ g, specific surface area are > 500m2/g；
(3) under static conditions, into the mixed system of step (2) by solvent volume than deionization is added for the amount of 1:3.5
Water, after standing 24 hours, mesoporous silicon oxide is taken out in filtering；
(4) after the mesoporous silicon oxide being obtained by filtration in step (3) being washed with deionized 4 times, by meso-porous titanium dioxide
The weight ratio of silicon and the deionized water of addition is that deionized water is added in 1:1.2, and the amount by silica weight than 2% weighs coupling
In agent kh550 addition system, ball milling mixing uniformly obtains mixture, and ball milling 0.5h obtains improved silica；
(5) improved silica and acrylic emulsion that step (4) obtains are stirred, obtain mixed solution；It will mix
It closes solution to be coated on medical catheter, the medical catheter of the coating coated with Chinese medicine composition can be prepared after drying；Its
In, the weight ratio of improved silica and acrylic emulsion is 1:1；Main pipe's material of the medical catheter is TPU.Before described
The material of capsule and rear capsule is natural emulsion.
The TPU is super branched polyurethane material；The super branched polyurethane is the super branched polyurethane of carboxylic acid group's sealing end,
It blocks and is prepared using carboxylic acid group after being reacted by polymerized monomer 2,3,4 with hyper-branched polyester (HBPs)；
The hyper-branched polyester (HBPs) is prepared by the following method: equipped with mechanical stirring, thermometer and spherical time
In the three-necked flask for flowing condenser pipe, ethylene glycol, N, bis- (2- hydroxyethyl) piperazines of N'- and trimellitic anhydride is added, is added
DBTDL, under nitrogen protection, in 40 DEG C of pre-polymerization 8h, then heating is heated to 100 DEG C, vacuumizes reaction 10h, until system acid
Value is lower than 30mgKOH/g, and cooling obtains colorless and transparent solid, i.e. hyper-branched polyester (HBPs)；
Wherein, No. CAS of bis- (2- hydroxyethyl) piperazines of the N, N'- is 122-96-3；The DBTDL is tin dilaurate
Dibutyl tin, No. CAS is 77-58-7；The ethylene glycol, N, the molar ratio of bis- (2- hydroxyethyl) piperazines of N'-, trimellitic anhydride
For 4:2:3；The additional amount of the DBTDL is the 0.3% of total monomer weight.
The polymerized monomer 2 is prepared by the following method: nitrogen atmosphere protection under, into four-hole bottle be added IPDI and
N,N-Dimethylformamide (DMF), stirring shakes up, and MPEG-1000, DBTDL and p-hydroxyanisole are dissolved into DMF later
In, dropping funel is poured into, mixed liquor is slowly dropped in the four-hole bottle that stirred, oil bath controls temperature at 30 DEG C, keeps the temperature 3-
4h is titrated by di-n-butylamine and determines reaction end, obtains polymerized monomer 2；
Wherein, the IPDI is isophorone diisocyanate, and No. CAS is 4098-71-9；The MPEG-1000 is poly-
Glycol monoethyl ether MPEG is bought from Nantong MICHAEL DRAKE Chemical Co., Ltd.；The DBTDL is dibutyl tin dilaurate, CAS
Number be 77-58-7；The molar ratio of described IPDI, MPEG-1000 are 1:1；The additional amount of the DBTDL is total monomer weight
0.1%；The concentration of the p-hydroxyanisole is 1000ppm.
The polymerized monomer 3 is prepared by the following method: under nitrogen atmosphere protection, front three being added into four-hole bottle
Base -1, hexamethylene-diisocyanate and n,N-Dimethylformamide (DMF) stirring shake up, later by 2- [2- (2- methoxyl group ethoxy
Base) ethyoxyl]-ethyl alcohol, DBTDL and p-hydroxyanisole are dissolved into DMF, pour into dropping funel, mixed liquor is slowly dripped
It is added in the four-hole bottle that stirred, oil bath controls temperature at 28 DEG C, keeps the temperature 3-4h, is titrated by di-n-butylamine and determines reaction eventually
Point obtains polymerized monomer 3；
Wherein, the trimethyl -1, No. CAS of hexamethylene-diisocyanate are 15646-96-5；2- [2- (the 2- methoxy
Base oxethyl) ethyoxyl] No. CAS of-ethyl alcohol be 112-35-6；The DBTDL is dibutyl tin dilaurate, and No. CAS is 77-
58-7；The hexamethylene diisocyanate, 2- [2- (2- methoxy ethoxy) ethyoxyl]-ethyl alcohol molar ratio be 1:1；It is described
The additional amount of DBTDL is the 0.1% of total monomer weight；The concentration of the p-hydroxyanisole is 1000ppm.
The polymerized monomer 4 is prepared by the following method: under nitrogen atmosphere protection, 2,4- bis- being added into four-hole bottle
Bis- azetidine -1,3- of oxo -1,3-, bis- (hexa-methylene) diisocyanate and n,N-Dimethylformamide stirring shake up, and later will
Fluoro- 4, the 6- dihydroxy-pyrimidine of 5- and (1S, 2S, 3S, 5S) -3- amino -2- fluoro- 5- (hydroxymethyl) cyclopentanol, DBTDL and
P-hydroxyanisole is dissolved into DMF, pours into dropping funel, and mixed liquor is slowly dropped in the four-hole bottle that stirred, oil bath
Temperature is controlled at 35 DEG C, keeps the temperature 3-4h, is titrated by di-n-butylamine and determines reaction end, obtain polymerized monomer 4；
Wherein, No. CAS of 2,4- dioxo -1,3- bis- azetidine -1,3- bis- (hexa-methylene) diisocyanate is
23501-81-7；No. CAS of the fluoro- 4,6- dihydroxy-pyrimidine of 5- is 106615-61-6；(1S, 2S, 3S, the 5S) -3- ammonia
No. CAS of base -2- fluoro- 5- (hydroxymethyl) cyclopentanol is 110289-08-2；Two azetidine -1 2,4- dioxo -1,3-,
3- bis- (hexa-methylene) diisocyanate, the fluoro- 4,6- dihydroxy-pyrimidine of 5-, the fluoro- 5- (hydroxyl of (1S, 2S, 3S, 5S) -3- amino -2-
Ylmethyl) cyclopentanol molar ratio be 3:2:4；The additional amount of the DBTDL is the 0.15% of total monomer weight；It is described to hydroxyl
The concentration of methyl phenyl ethers anisole is 1800ppm.
The super branched polyurethane is prepared by polymerized monomer 2,3,4 and hyper-branched polyester (HBPs), step include:
The polymerized monomer 2,3,4 and hyper-branched polyester (HBPs) are added in there-necked flask, DMF is added later, mixing shakes up, temperature 70
DEG C, nitrogen protection is flowed back under stirring with condenser pipe, is vigorously stirred after keeping the temperature 5h, after fully reacting, by obtained product in vacuum
55 DEG C evaporate solvent DMF by rotary evaporator, obtain super branched polyurethane crude product；
Wherein, the polymerized monomer 2,3,4 and the molar ratio of hyper-branched polyester (HBPs) are 1.2:1.2:1.5:1.
The preparation step of the super branched polyurethane of carboxylic acid group's sealing end is as described below: p-methyl benzenesulfonic acid is added to upper one
It walks in the super branched polyurethane system prepared, then succinic anhydride is dissolved in n,N-dimethylacetamide, then slowly drips it
It is added in above-mentioned system, is stirred when being added dropwise, dripped in 0.5h, 3-4h is then reacted at 80-90 DEG C, is then evaporated under reduced pressure
Solvent in removing system obtains the super branched polyurethane of carboxylic acid group's sealing end；
Wherein, the weight ratio of the p-methyl benzenesulfonic acid and super branched polyurethane is 1:42；The succinic anhydride and hyperbranched
The molar ratio of polymer is 3.5:1.
Embodiment 2
Embodiment 2 provides a kind of preparation method of medical catheter, and step includes:
(1) according to the weight ratio 3:1 of solvent and Chinese medicine composition, Chinese medicine composition and solvent are mixed；Wherein, described molten
It is mixed solvent that 75:22 is compounded that agent, which is according to the volume ratio of ethyl alcohol and n-butanol,；The Chinese medicine composition is according to thickness
Plain extract, Japanese beauty-berry, Folium Isatidis extract, Baical Skullcap root P.E weight ratio be that 2.5:1.5:2.5:1 is compounded
Mixture；
(2) mesoporous silicon oxide is added in step (1), mixing 12 hours is then stirred under ultrasonic agitation,
In, the weight ratio of the mesoporous silicon oxide and Chinese medicine composition is 1:4.5；The partial size of the mesoporous silicon oxide be 90 ±
15nm, mesoporous pore size 3-4nm, pore volume > 0.5cm3/ g, specific surface area are > 500m2/g；
(3) under static conditions, into the mixed system of step (2) by solvent volume than deionization is added for the amount of 1:3.5
Water, after standing 24 hours, mesoporous silicon oxide is taken out in filtering；
(4) after the mesoporous silicon oxide being obtained by filtration in step (3) being washed with deionized 4 times, by meso-porous titanium dioxide
The weight ratio of silicon and the deionized water of addition is that deionized water is added in 1:1.2, and the amount by silica weight than 2% weighs coupling
In agent kh550 addition system, ball milling mixing uniformly obtains mixture, and ball milling 0.5h obtains improved silica；
(5) improved silica and acrylic emulsion that step (4) obtains are stirred, obtain mixed solution；It will mix
It closes solution to be coated on medical catheter, the medical catheter of the coating coated with Chinese medicine composition can be prepared after drying；Its
In, the weight ratio of improved silica and acrylic emulsion is 1:1；Main pipe's material of the medical catheter is PVC.Before described
The material of capsule and rear capsule is natural emulsion.
Embodiment 3
Embodiment 3 provides a kind of preparation method of medical catheter, and step includes:
(1) according to the weight ratio 2.5:1 of solvent and Chinese medicine composition, Chinese medicine composition and solvent are mixed；Wherein, described
It is mixed solvent that 70:20 is compounded that solvent, which is according to the volume ratio of ethyl alcohol and n-butanol,；The Chinese medicine composition be according to
Magnolia cortex P.E, Japanese beauty-berry, Folium Isatidis extract, Baical Skullcap root P.E weight ratio be the mixing that compounds of 2:1:2:1
Object；
(2) mesoporous silicon oxide is added in step (1), mixing 12 hours is then stirred under ultrasonic agitation,
In, the weight ratio of the mesoporous silicon oxide and Chinese medicine composition is 1:4；The partial size of the mesoporous silicon oxide be 90 ±
15nm, mesoporous pore size 3-4nm, pore volume > 0.5cm3/ g, specific surface area are > 500m2/g；
(3) under static conditions, into the mixed system of step (2) by solvent volume than deionization is added for the amount of 1:3.5
Water, after standing 24 hours, mesoporous silicon oxide is taken out in filtering；
(4) after the mesoporous silicon oxide being obtained by filtration in step (3) being washed with deionized 4 times, by meso-porous titanium dioxide
The weight ratio of silicon and the deionized water of addition is that deionized water is added in 1:1.1, and the amount by silica weight than 1.0% weighs even
Join in agent kh550 addition system, ball milling mixing uniformly obtains mixture, and ball milling 0.5h obtains improved silica；
(5) improved silica and acrylic emulsion that step (4) obtains are stirred, obtain mixed solution；It will mix
It closes solution to be coated on medical catheter, the medical catheter of the coating coated with Chinese medicine composition can be prepared after drying；Its
In, the weight ratio of improved silica and acrylic emulsion is 1:0.6；Main pipe's material of the medical catheter is TPU.It is described
The material of preceding capsule and rear capsule is natural emulsion.
The TPU is super branched polyurethane material；The super branched polyurethane is the super branched polyurethane of carboxylic acid group's sealing end,
It blocks and is prepared using carboxylic acid group after being reacted by polymerized monomer 2,3,4 with hyper-branched polyester (HBPs)；
The preparation method is the same as that of Example 1 for the hyper-branched polyester (HBPs).
The preparation method is the same as that of Example 1 for the polymerized monomer 2.
The preparation method is the same as that of Example 1 for the polymerized monomer 3.
The preparation method is the same as that of Example 1 for the polymerized monomer 4.
The preparation method is the same as that of Example 1 for the super branched polyurethane, the difference is that: the polymerized monomer 2,3,4 with
The molar ratio of hyper-branched polyester (HBPs) is 1:1.5:1:1.
The preparation method is the same as that of Example 1 for the super branched polyurethane of carboxylic acid group's sealing end, the difference is that: the fourth two
The molar ratio of acid anhydrides and dissaving polymer is 2:1.
Embodiment 4
Embodiment 4 provides a kind of preparation method of medical catheter, and step includes:
(1) according to the weight ratio 3.5:1 of solvent and Chinese medicine composition, Chinese medicine composition and solvent are mixed；Wherein, described
It is mixed solvent that 80:30 is compounded that solvent, which is according to the volume ratio of ethyl alcohol and n-butanol,；The Chinese medicine composition be according to
Magnolia cortex P.E, Japanese beauty-berry, Folium Isatidis extract, Baical Skullcap root P.E weight ratio be the mixing that compounds of 3:2:3:1
Object；
(2) mesoporous silicon oxide is added in step (1), mixing 12 hours is then stirred under ultrasonic agitation,
In, the weight ratio of the mesoporous silicon oxide and Chinese medicine composition is 1:5；The partial size of the mesoporous silicon oxide be 90 ±
15nm, mesoporous pore size 3-4nm, pore volume > 0.5cm3/ g, specific surface area are > 500m2/g；
(3) under static conditions, into the mixed system of step (2) by solvent volume than deionization is added for the amount of 1:3.5
Water, after standing 24 hours, mesoporous silicon oxide is taken out in filtering；
(4) after the mesoporous silicon oxide being obtained by filtration in step (3) being washed with deionized 4 times, by meso-porous titanium dioxide
The weight ratio of silicon and the deionized water of addition is that deionized water is added in 1:1.3, and the amount by silica weight than 2.5% weighs even
Join in agent kh550 addition system, ball milling mixing uniformly obtains mixture, and ball milling 0.5h obtains improved silica；
(5) improved silica and acrylic emulsion that step (4) obtains are stirred, obtain mixed solution；It will mix
It closes solution to be coated on medical catheter, the medical catheter of the coating coated with Chinese medicine composition can be prepared after drying；Its
In, the weight ratio of improved silica and acrylic emulsion is 1:1.3；Main pipe's material of the medical catheter is TPU.It is described
The material of preceding capsule and rear capsule is natural emulsion.
The TPU is super branched polyurethane material；The super branched polyurethane is the super branched polyurethane of carboxylic acid group's sealing end,
It blocks and is prepared using carboxylic acid group after being reacted by polymerized monomer 2,3,4 with hyper-branched polyester (HBPs)；
The preparation method is the same as that of Example 1 for the hyper-branched polyester (HBPs).
The preparation method is the same as that of Example 1 for the polymerized monomer 2.
The preparation method is the same as that of Example 1 for the polymerized monomer 3.
The preparation method is the same as that of Example 1 for the polymerized monomer 4.
The preparation method is the same as that of Example 1 for the super branched polyurethane, the difference is that: the polymerized monomer 2,3,4 with
The molar ratio of hyper-branched polyester (HBPs) is 1.5:1.2:1.2:1.
The preparation method is the same as that of Example 1 for the super branched polyurethane of carboxylic acid group's sealing end, the difference is that: the fourth two
The molar ratio of acid anhydrides and dissaving polymer is 4:1.
Embodiment 5
Embodiment 5 provides a kind of preparation method of medical catheter, and step includes:
(1) according to the weight ratio 3:1 of solvent and Chinese medicine composition, Chinese medicine composition and solvent are mixed；Wherein, described molten
It is mixed solvent that 75:22 is compounded that agent, which is according to the volume ratio of ethyl alcohol and n-butanol,；The Chinese medicine composition is according to thickness
Plain extract, Japanese beauty-berry, Folium Isatidis extract, Baical Skullcap root P.E weight ratio be that 2.5:1.5:2.5:1 is compounded
Mixture；
(2) mesoporous silicon oxide is added in step (1), mixing 12 hours is then stirred under ultrasonic agitation,
In, the weight ratio of the mesoporous silicon oxide and Chinese medicine composition is 1:4.5；The partial size of the mesoporous silicon oxide be 90 ±
15nm, mesoporous pore size 3-4nm, pore volume > 0.5cm3/ g, specific surface area are > 500m2/g；
(3) under static conditions, into the mixed system of step (2) by solvent volume than deionization is added for the amount of 1:3.5
Water, after standing 24 hours, mesoporous silicon oxide is taken out in filtering；
(4) after the mesoporous silicon oxide being obtained by filtration in step (3) being washed with deionized 4 times, by meso-porous titanium dioxide
The weight ratio of silicon and the deionized water of addition is that deionized water is added in 1:1.2, and the amount by silica weight than 2% weighs coupling
In agent kh550 addition system, ball milling mixing uniformly obtains mixture, and ball milling 0.5h obtains improved silica；
(5) improved silica and acrylic emulsion that step (4) obtains are stirred, obtain mixed solution；It will mix
It closes solution to be coated on medical catheter, the medical catheter of the coating coated with Chinese medicine composition can be prepared after drying；Its
In, the weight ratio of improved silica and acrylic emulsion is 1:1；Main pipe's material of the medical catheter is TPU.Before described
The material of capsule and rear capsule is natural emulsion.
The TPU is super branched polyurethane material；The super branched polyurethane is by polymerized monomer 2,3,4 and hyperbranched poly
It is prepared after ester (HBPs) reaction using sealing end；
The preparation method is the same as that of Example 1 for the hyper-branched polyester (HBPs).
The preparation method is the same as that of Example 1 for the polymerized monomer 2.
The preparation method is the same as that of Example 1 for the polymerized monomer 3.
The preparation method is the same as that of Example 1 for the polymerized monomer 4.
The preparation method is the same as that of Example 1 for the super branched polyurethane.
The preparation method is the same as that of Example 1 for the super branched polyurethane of the sealing end, the difference is that: by the succinic anhydride
P-methyl benzenesulfonic acid acetic anhydride is replaced with, No. CAS is 26908-82-7.
Embodiment 6
Embodiment 6 provides a kind of preparation method of medical catheter, and step includes:
(1) according to the weight ratio 3:1 of solvent and Chinese medicine composition, Chinese medicine composition and solvent are mixed；Wherein, described molten
It is mixed solvent that 75:22 is compounded that agent, which is according to the volume ratio of ethyl alcohol and n-butanol,；The Chinese medicine composition is according to thickness
Plain extract, Japanese beauty-berry, Folium Isatidis extract, Baical Skullcap root P.E weight ratio be that 2.5:1.5:2.5:1 is compounded
Mixture；
(2) mesoporous silicon oxide is added in step (1), mixing 12 hours is then stirred under ultrasonic agitation,
In, the weight ratio of the mesoporous silicon oxide and Chinese medicine composition is 1:4.5；The partial size of the mesoporous silicon oxide be 90 ±
15nm, mesoporous pore size 3-4nm, pore volume > 0.5cm3/ g, specific surface area are > 500m2/g；
(3) under static conditions, into the mixed system of step (2) by solvent volume than deionization is added for the amount of 1:3.5
Water, after standing 24 hours, mesoporous silicon oxide is taken out in filtering；
(4) after the mesoporous silicon oxide being obtained by filtration in step (3) being washed with deionized 4 times, by meso-porous titanium dioxide
The weight ratio of silicon and the deionized water of addition is that deionized water is added in 1:1.2, and the amount by silica weight than 2% weighs coupling
In agent kh550 addition system, ball milling mixing uniformly obtains mixture, and ball milling 0.5h obtains improved silica；
(5) improved silica and acrylic emulsion that step (4) obtains are stirred, obtain mixed solution；It will mix
It closes solution to be coated on medical catheter, the medical catheter of the coating coated with Chinese medicine composition can be prepared after drying；Its
In, the weight ratio of improved silica and acrylic emulsion is 1:1；Main pipe's material of the medical catheter is TPU.Before described
The material of capsule and rear capsule is natural emulsion.
The TPU is super branched polyurethane material；The super branched polyurethane is that super branched polyurethane (is sealed without carboxylic acid group
End) it is prepared by polymerized monomer 2,3,4 and hyper-branched polyester (HBPs)；
The preparation method is the same as that of Example 1 for the hyper-branched polyester (HBPs).
The preparation method is the same as that of Example 1 for the polymerized monomer 2.
The preparation method is the same as that of Example 1 for the polymerized monomer 3.
The preparation method is the same as that of Example 1 for the polymerized monomer 4.
The preparation method is the same as that of Example 1 for the super branched polyurethane.
Embodiment 7
Embodiment 7 provides a kind of preparation method of medical catheter, and step includes:
(1) according to the weight ratio 3:1 of solvent and Chinese medicine composition, Chinese medicine composition and solvent are mixed；Wherein, described molten
It is mixed solvent that 75:22 is compounded that agent, which is according to the volume ratio of ethyl alcohol and n-butanol,；The Chinese medicine composition is according to thickness
Plain extract, Japanese beauty-berry, Folium Isatidis extract, Baical Skullcap root P.E weight ratio be that 2.5:1.5:2.5:1 is compounded
Mixture；
(2) mesoporous silicon oxide is added in step (1), mixing 12 hours is then stirred under ultrasonic agitation,
In, the weight ratio of the mesoporous silicon oxide and Chinese medicine composition is 1:4.5；The partial size of the mesoporous silicon oxide be 90 ±
15nm, mesoporous pore size 3-4nm, pore volume > 0.5cm3/ g, specific surface area are > 500m2/g；
(3) under static conditions, into the mixed system of step (2) by solvent volume than deionization is added for the amount of 1:3.5
Water, after standing 24 hours, mesoporous silicon oxide is taken out in filtering；
(4) after the mesoporous silicon oxide being obtained by filtration in step (3) being washed with deionized 4 times, by meso-porous titanium dioxide
The weight ratio of silicon and the deionized water of addition is that deionized water is added in 1:1.2, and the amount by silica weight than 2% weighs coupling
In agent kh550 addition system, ball milling mixing uniformly obtains mixture, and ball milling 0.5h obtains improved silica；
(5) improved silica and acrylic emulsion that step (4) obtains are stirred, obtain mixed solution；It will mix
It closes solution to be coated on medical catheter, the medical catheter of the coating coated with Chinese medicine composition can be prepared after drying；Its
In, the weight ratio of improved silica and acrylic emulsion is 1:1；Main pipe's material of the medical catheter is TPU.Before described
The material of capsule and rear capsule is natural emulsion.
The TPU is super branched polyurethane material；The super branched polyurethane is the super branched polyurethane of carboxylic acid group's sealing end,
It blocks and is prepared using carboxylic acid group after being reacted by polymerized monomer 2,3,4 with hyper-branched polyester (HBPs)；
The preparation method is the same as that of Example 1 for the hyper-branched polyester (HBPs).
The preparation method is the same as that of Example 1 for the polymerized monomer 2.
The preparation method is the same as that of Example 1 for the polymerized monomer 3.
The preparation method is the same as that of Example 1 for the polymerized monomer 4.
The preparation method is the same as that of Example 1 for the super branched polyurethane, the difference is that: the polymerized monomer 2,3,4 with
The molar ratio of hyper-branched polyester (HBPs) is 0.1:1.2:1.5:1.
The preparation method is the same as that of Example 1 for the super branched polyurethane of carboxylic acid group's sealing end.
Embodiment 8
Embodiment 8 provides a kind of preparation method of medical catheter, and step includes:
(1) according to the weight ratio 3:1 of solvent and Chinese medicine composition, Chinese medicine composition and solvent are mixed；Wherein, described molten
It is mixed solvent that 75:22 is compounded that agent, which is according to the volume ratio of ethyl alcohol and n-butanol,；The Chinese medicine composition is according to thickness
Plain extract, Japanese beauty-berry, Folium Isatidis extract, Baical Skullcap root P.E weight ratio be that 2.5:1.5:2.5:1 is compounded
Mixture；
(2) mesoporous silicon oxide is added in step (1), mixing 12 hours is then stirred under ultrasonic agitation,
In, the weight ratio of the mesoporous silicon oxide and Chinese medicine composition is 1:4.5；The partial size of the mesoporous silicon oxide be 90 ±
15nm, mesoporous pore size 3-4nm, pore volume > 0.5cm3/ g, specific surface area are > 500m2/g；
(3) under static conditions, into the mixed system of step (2) by solvent volume than deionization is added for the amount of 1:3.5
Water, after standing 24 hours, mesoporous silicon oxide is taken out in filtering；
(4) after the mesoporous silicon oxide being obtained by filtration in step (3) being washed with deionized 4 times, by meso-porous titanium dioxide
The weight ratio of silicon and the deionized water of addition is that deionized water is added in 1:1.2, and the amount by silica weight than 2% weighs coupling
In agent kh550 addition system, ball milling mixing uniformly obtains mixture, and ball milling 0.5h obtains improved silica；
(5) improved silica and acrylic emulsion that step (4) obtains are stirred, obtain mixed solution；It will mix
It closes solution to be coated on medical catheter, the medical catheter of the coating coated with Chinese medicine composition can be prepared after drying；Its
In, the weight ratio of improved silica and acrylic emulsion is 1:1；Main pipe's material of the medical catheter is TPU.Before described
The material of capsule and rear capsule is natural emulsion.
The TPU is super branched polyurethane material；The super branched polyurethane is the super branched polyurethane of carboxylic acid group's sealing end,
It blocks and is prepared using carboxylic acid group after being reacted by polymerized monomer 2,3,4 with hyper-branched polyester (HBPs)；
The preparation method is the same as that of Example 1 for the hyper-branched polyester (HBPs).
The preparation method is the same as that of Example 1 for the polymerized monomer 2.
The preparation method is the same as that of Example 1 for the polymerized monomer 3.
The preparation method is the same as that of Example 1 for the polymerized monomer 4.
The preparation method is the same as that of Example 1 for the super branched polyurethane, the difference is that: the polymerized monomer 2,3,4 with
The molar ratio of hyper-branched polyester (HBPs) is 1.2:0.1:1.5:1.
The preparation method is the same as that of Example 1 for the super branched polyurethane of carboxylic acid group's sealing end.
Embodiment 9
Embodiment 9 provides a kind of preparation method of medical catheter, and step includes:
(1) according to the weight ratio 3:1 of solvent and Chinese medicine composition, Chinese medicine composition and solvent are mixed；Wherein, described molten
It is mixed solvent that 75:22 is compounded that agent, which is according to the volume ratio of ethyl alcohol and n-butanol,；The Chinese medicine composition is according to thickness
Plain extract, Japanese beauty-berry, Folium Isatidis extract, Baical Skullcap root P.E weight ratio be that 2.5:1.5:2.5:1 is compounded
Mixture；
(2) mesoporous silicon oxide is added in step (1), mixing 12 hours is then stirred under ultrasonic agitation,
In, the weight ratio of the mesoporous silicon oxide and Chinese medicine composition is 1:4.5；The partial size of the mesoporous silicon oxide be 90 ±
15nm, mesoporous pore size 3-4nm, pore volume > 0.5cm3/ g, specific surface area are > 500m2/g；
(3) under static conditions, into the mixed system of step (2) by solvent volume than deionization is added for the amount of 1:3.5
Water, after standing 24 hours, mesoporous silicon oxide is taken out in filtering；
(4) after the mesoporous silicon oxide being obtained by filtration in step (3) being washed with deionized 4 times, by meso-porous titanium dioxide
The weight ratio of silicon and the deionized water of addition is that deionized water is added in 1:1.2, and the amount by silica weight than 2% weighs coupling
In agent kh550 addition system, ball milling mixing uniformly obtains mixture, and ball milling 0.5h obtains improved silica；
(5) improved silica and acrylic emulsion that step (4) obtains are stirred, obtain mixed solution；It will mix
It closes solution to be coated on medical catheter, the medical catheter of the coating coated with Chinese medicine composition can be prepared after drying；Its
In, the weight ratio of improved silica and acrylic emulsion is 1:1；Main pipe's material of the medical catheter is TPU.Before described
The material of capsule and rear capsule is natural emulsion.
The TPU is super branched polyurethane material；The super branched polyurethane is the super branched polyurethane of carboxylic acid group's sealing end,
It blocks and is prepared using carboxylic acid group after being reacted by polymerized monomer 2,3,4 with hyper-branched polyester (HBPs)；
The preparation method is the same as that of Example 1 for the hyper-branched polyester (HBPs).
The preparation method is the same as that of Example 1 for the polymerized monomer 2.
The preparation method is the same as that of Example 1 for the polymerized monomer 3.
The preparation method is the same as that of Example 1 for the polymerized monomer 4.
The preparation method is the same as that of Example 1 for the super branched polyurethane, the difference is that: the polymerized monomer 2,3,4 with
The molar ratio of hyper-branched polyester (HBPs) is 1.2:1.2:0.1:1.
The preparation method is the same as that of Example 1 for the super branched polyurethane of carboxylic acid group's sealing end.
Embodiment 10
Embodiment 10 provides a kind of preparation method of medical catheter, and step includes:
(1) according to the weight ratio 3:1 of solvent and Chinese medicine composition, Chinese medicine composition and solvent are mixed；Wherein, described molten
It is mixed solvent that 75:22 is compounded that agent, which is according to the volume ratio of ethyl alcohol and n-butanol,；The Chinese medicine composition is according to thickness
Plain extract, Japanese beauty-berry, Folium Isatidis extract, Baical Skullcap root P.E weight ratio be that 2.5:1.5:2.5:1 is compounded
Mixture；
(2) mesoporous silicon oxide is added in step (1), mixing 12 hours is then stirred under ultrasonic agitation,
In, the weight ratio of the mesoporous silicon oxide and Chinese medicine composition is 1:4.5；The partial size of the mesoporous silicon oxide be 20 ±
10nm, mesoporous pore size 3-4nm, pore volume 0.5cm3/ g, specific surface area 145-160m2/g；
(3) under static conditions, into the mixed system of step (2) by solvent volume than deionization is added for the amount of 1:3.5
Water, after standing 24 hours, mesoporous silicon oxide is taken out in filtering；
(4) after the mesoporous silicon oxide being obtained by filtration in step (3) being washed with deionized 4 times, by meso-porous titanium dioxide
The weight ratio of silicon and the deionized water of addition is that deionized water is added in 1:1.2, and the amount by silica weight than 2% weighs coupling
In agent kh550 addition system, ball milling mixing uniformly obtains mixture, and ball milling 0.5h obtains improved silica；
(5) improved silica and acrylic emulsion that step (4) obtains are stirred, obtain mixed solution；It will mix
It closes solution to be coated on medical catheter, the medical catheter of the coating coated with Chinese medicine composition can be prepared after drying；Its
In, the weight ratio of improved silica and acrylic emulsion is 1:1；Main pipe's material of the medical catheter is TPU.Before described
The material of capsule and rear capsule is natural emulsion.
The TPU is the same as embodiment 1.
Embodiment 11
Embodiment 11 provides a kind of preparation method of medical catheter, and step includes:
(1) according to the weight ratio 3:1 of solvent and Chinese medicine composition, Chinese medicine composition and solvent are mixed；Wherein, described molten
It is mixed solvent that 75:22 is compounded that agent, which is according to the volume ratio of ethyl alcohol and n-butanol,；The Chinese medicine composition is according to thickness
Plain extract, Japanese beauty-berry, Folium Isatidis extract, Baical Skullcap root P.E weight ratio be that 2.5:1.5:2.5:1 is compounded
Mixture；
(2) mesoporous silicon oxide is added in step (1), mixing 12 hours is then stirred under ultrasonic agitation,
In, the weight ratio of the mesoporous silicon oxide and Chinese medicine composition is 0.1:4.5；The partial size of the mesoporous silicon oxide be 90 ±
15nm, mesoporous pore size 3-4nm, pore volume > 0.5cm3/ g, specific surface area are > 500m2/g；
(3) under static conditions, into the mixed system of step (2) by solvent volume than deionization is added for the amount of 1:3.5
Water, after standing 24 hours, mesoporous silicon oxide is taken out in filtering；
(4) after the mesoporous silicon oxide being obtained by filtration in step (3) being washed with deionized 4 times, by meso-porous titanium dioxide
The weight ratio of silicon and the deionized water of addition is that deionized water is added in 1:1.2, and the amount by silica weight than 2% weighs coupling
In agent kh550 addition system, ball milling mixing uniformly obtains mixture, and ball milling 0.5h obtains improved silica；
(5) improved silica and acrylic emulsion that step (4) obtains are stirred, obtain mixed solution；It will mix
It closes solution to be coated on medical catheter, the medical catheter of the coating coated with Chinese medicine composition can be prepared after drying；Its
In, the weight ratio of improved silica and acrylic emulsion is 1:1；Main pipe's material of the medical catheter is TPU.Before described
The material of capsule and rear capsule is natural emulsion.
The TPU is the same as embodiment 1.
Embodiment 12
Embodiment 12 provides a kind of preparation method of medical catheter, and step includes:
(1) according to the weight ratio 3:1 of solvent and Chinese medicine composition, Chinese medicine composition and solvent are mixed；Wherein, described molten
It is mixed solvent that 75:22 is compounded that agent, which is according to the volume ratio of ethyl alcohol and n-butanol,；The Chinese medicine composition is according to thickness
Plain extract, Japanese beauty-berry, Folium Isatidis extract, Baical Skullcap root P.E weight ratio be that 2.5:1.5:2.5:1 is compounded
Mixture；
(2) mesoporous silicon oxide is added in step (1), mixing 12 hours is then stirred under ultrasonic agitation,
In, the weight ratio of the mesoporous silicon oxide and Chinese medicine composition is 1:4.5；The partial size of the mesoporous silicon oxide be 90 ±
15nm, mesoporous pore size 3-4nm, pore volume > 0.5cm3/ g, specific surface area are > 500m2/g；
(3) under static conditions, into the mixed system of step (2) by solvent volume than deionization is added for the amount of 1:3.5
Water, after standing 24 hours, mesoporous silicon oxide is taken out in filtering；
(4) after the mesoporous silicon oxide being obtained by filtration in step (3) being washed with deionized 4 times, by meso-porous titanium dioxide
The weight ratio of silicon and the deionized water of addition is that deionized water is added in 1:1.2, and the amount by silica weight than 2% weighs coupling
In agent kh550 addition system, ball milling mixing uniformly obtains mixture, and ball milling 0.5h obtains improved silica；
(5) improved silica and acrylic emulsion that step (4) obtains are stirred, obtain mixed solution；It will mix
It closes solution to be coated on medical catheter, the medical catheter of the coating coated with Chinese medicine composition can be prepared after drying；Its
In, the weight ratio of improved silica and acrylic emulsion is 1:0.1；Main pipe's material of the medical catheter is TPU.It is described
The material of preceding capsule and rear capsule is natural emulsion.
The TPU is the same as embodiment 1.
Performance evaluation
1, adhesive force tests test method: product is centered around in the cylinder that diameter is 10cm clockwise, is kept for 1 hour
Afterwards；On being centered around the cylinder that diameter is 10cm counterclockwise, kept for 1 hour；After so circulation 10 times, observe on medical catheter
Middle medicine coating fall off, remove situation, evaluation result is as follows: coating shedding area is more than or equal to 40%, is denoted as 1；It applies
Layer falls off area more than or equal to 20%, and less than 40%, is denoted as 2；Coating shedding area is more than or equal to 10%, and less than 20%,
It is denoted as 3；Coating shedding area is more than or equal to 5%, and less than 10%, is denoted as 4；Coating shedding area is denoted as 5 less than 5%.
2, the size measuring after free wxpansion:
Test method is surveyed when preceding intraluminal pressure in four steps described in application method is reached 0.25MPa using slide calliper rule
Size after measuring free wxpansion, every group of embodiment or comparative example measure five times；The water pocket specification used in test is 32 rule
Lattice, i.e. D2 are 32, L1 54mm, the franchise of L2 53mm, D2 be within ± 5mm it is qualified, the franchise of L1 and L2 are in ± 10mm
Within be qualified (D2, L1, L2 can refer to shown in Fig. 1).
3, maximum collapse diameter is tested:
Test method: the high pressure water pocket after using in a contracted state, using calliper to measure maximum gauge, every group of implementation
Example or comparative example are averaged after measuring five times, are denoted as D3, using shrinking percentage=∣ D3-D2 ∣/D2 shrinkage from mold dimensions, are shunk
Rate is qualification less than 30%.
Table 1
Claims (10)
1. a kind of Chinese medicine composition for medical catheter, which is characterized in that including Magnolia cortex P.E, Japanese beauty-berry, smalt
Leaf extract, Baical Skullcap root P.E.
2. Chinese medicine composition according to claim 1, which is characterized in that the Magnolia cortex P.E, Japanese beauty-berry, smalt
Leaf extract, Baical Skullcap root P.E weight ratio be (2-3): (1-2): (2-3): 1.
3. a kind of medical catheter, which is characterized in that the coating containing Chinese medicine composition as described in claim 1.
4. a kind of preparation method of medical catheter according to claim 3, which is characterized in that step includes:
(1) according to weight ratio, Chinese medicine composition and solvent are mixed；
(2) mesoporous silicon oxide is added in step (1), mixing 10-15 hours is then stirred under ultrasonic agitation；
(3) under static conditions, deionized water is added for the amount of 1:(2-5) by solvent volume ratio into the mixed system of step (2),
After standing 20-30 hours, mesoporous silicon oxide is taken out in filtering；
(4) it after the mesoporous silicon oxide being obtained by filtration in step (3) being washed with deionized 3-4 times, is added in deionization, presses
The amount of silica weight ratio 1.0%-2.5% weighs in coupling agent kh550 addition system, and ball milling mixing is uniformly mixed
Material, ball milling 0.5-1h obtain improved silica；
(5) improved silica and acrylic emulsion that step (4) obtains are stirred, obtain mixed solution；It will mix molten
Liquid is coated on medical catheter, and the medical catheter of the coating coated with Chinese medicine composition can be prepared after drying.
5. the preparation method of medical catheter according to claim 4, which is characterized in that solvent is in the step (1)
The weight ratio of drug composition is (2.5-3.5): 1；It is (70-80) that the solvent, which is according to the volume ratio of ethyl alcohol and n-butanol:
(20-30) compounds obtained mixed solvent.
6. the preparation method of medical catheter according to claim 4, which is characterized in that step (2) the intermediary hole dioxy
The partial size of SiClx is 90 ± 20nm, mesoporous pore size 1-10nm, pore volume > 0.5cm3/ g, specific surface area are > 500m2/g。
7. the preparation method of medical catheter according to claim 4, which is characterized in that step (2) the intermediary hole dioxy
SiClx and the weight ratio of Chinese medicine composition are 1:(4-5).
8. the preparation method of medical catheter according to claim 4, which is characterized in that step (4) the intermediary hole dioxy
The weight ratio of SiClx and the deionized water of addition is 1:(1.1-1.3).
9. the preparation method of medical catheter according to claim 4, which is characterized in that modified dioxy in the step (5)
SiClx and the weight ratio of acrylic emulsion are 1:(0.6-1.3).
10. the preparation method of medical catheter according to claim 4, which is characterized in that medical catheter in the step (5)
Main pipe's material be TPU or PVC；Preceding capsule and rear capsule are additionally provided on the conduit, and the material of the preceding capsule and rear capsule is TPU
Or natural emulsion.
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN115569240A (en) * | 2022-09-15 | 2023-01-06 | 辽宁垠艺生物科技股份有限公司 | Medicine coating plastic capsule and preparation method thereof |
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| CN101468108A (en) * | 2007-12-28 | 2009-07-01 | 天津市中宝制药有限公司 | Gel patch for treating chronic gastritis and method for preparing the same |
| CN102905735A (en) * | 2010-05-27 | 2013-01-30 | 汉莫堤克股份有限公司 | Medical product with particle-free coating releasing active substance |
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| CN115569240A (en) * | 2022-09-15 | 2023-01-06 | 辽宁垠艺生物科技股份有限公司 | Medicine coating plastic capsule and preparation method thereof |
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