CN104490869A - Application of atractylenolide-III derivative in preparation of platelet aggregation resisting drug and platelet aggregation resisting drug - Google Patents
Application of atractylenolide-III derivative in preparation of platelet aggregation resisting drug and platelet aggregation resisting drug Download PDFInfo
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- A61K31/33—Heterocyclic compounds
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Abstract
The present invention relates to a kind of medicament for resisting platelet aggregation, including III derivative of atractylodes lactone as shown in structural formula 1:
The invention further relates to application of III derivative of atractylodes lactone in the drug for preparing platelet aggregation-against. It is simple that the present invention provides a kind of composition, and the drug with platelet aggregation-against generated by the effective component extracts of the effective component of natural medicinal raw material or its medicinal raw material, with good effect, have no toxic side effect, be not likely to produce tolerance, and it is convenient to take be generally applicable to by platelet aggregation rate it is excessively high caused by blood viscousness and the problems such as thrombus.
Description
Technical field
The present invention relates to a kind of field of medicaments, particularly relate to the medicine and application of preparing atractylenolideⅢ derivant antiplatelet aggregation.
Background technology
Modern medicine is thought, the formation of thrombosis and platelet aggregation rate is too high certain contact.
Thrombosis starts from local clotting mechanism, after the thrombosis of hyperfunction endarterium surface, thrombosis cover by the endotheliocyte of hypertrophy, and the platelet be incorporated in arterial wall thrombosis and leukocyte disintegrate and disengage lipid and other active substances, form atheromatous plaque gradually.The latter thinks that primary disease starts from Artery injury platelet activating factor (PAF) and increases, and platelet adheres at this place assembles then, fibrin deposition occurs subsequently and forms microthrombus.Some active substances are disengaged after platelet aggregation, wherein TXA2. (thromboxaneA2, TXA2) prostacyclin (prostacycline of blood vessel wall synthesis can be resisted, what PGI2) have makes platelet disaggregation and angiectatic effect, and promotes platelet to assemble further and vasoconstriction; Platelet derived growth factor (platelet derived growth factor) can stimulate the hyperplasia of smooth muscle shrink and vacillate to inner membrance; 5-hydroxy tryptamine and fiber mother cell growth factor (fibroblast growth factor) can stimulate fibroblast smooth muscle cell and endotheli ocytosis epinephrine and adenosine diphosphate (ADP) that platelet can be impelled to assemble further: factor Ⅷ makes platelet adhere to further; Platelet factor 4 (platelet factor 4) can make vasoconstriction; Plasminogen activator inhibitor (PAI) makes the dissolving of thrombosis be suppressed these materials endotheliocyte to be damaged further thus under causing LDL to enter inner membrance and inner membrance; Make mononuclear cell be gathered in inner membrance and develop into foam cell; Make smooth muscle cell proliferation move into inner membrance and engulf lipid; And make endothelial cell proliferation all be conducive to atherosis formation.
Blood coagulation system and anticoagulation system is there is in blood of human body.Under normal circumstances, the two remains dynamic equilibrium to ensure blood proper flow in the blood vessel, also thrombosis can not be formed, under special circumstances, as blood vessel has sclerosis, narrow equivalent damage cold weather, in the situations such as excessive sweating, hypopiesia, shortage drinking-water, slow blood flow, pachyemia thickness can be made, cause coagulation function hyperfunction or anticoagulating activity when weakening, then can break this balance, people is in " easy bolt state ".Thrombotic disease can occur in blood vessel Anywhere, thrombosis is along with blood is at intravascular flow, if stopped in cerebral artery vessel, the circulation hindering cerebral arteries normal blood is exactly cerebral thrombosis, thus cause cerebral infarction outbreak, if plug the coronary artery of heart, then can bring out myocardial infarction, in addition, lower limb arterial thrombus deep vein thrombosis of lower extremity and pulmonary infarction etc. is also had.
Thrombosis, great majority there will be serious symptoms once falling ill, as the aphasia hemiplegia of cerebral infarction; The violent pareordia angor of myocardial infarction; Lung blocks the symptom such as violent chest pain, dyspnea, spitting of blood caused; Have a pain in the leg bitterly as lower limb formation thrombosis then can cause two, or occur coolness and intermittent claudication etc.The CR Critical heart, cerebral infarction and lung infraction also can cause sudden death.But sometimes also can non-evident sympton, as common deep venous thrombosis of lower limbs, only have the swollen discomfort of shank acid, a lot of patient thinks tired or catches a cold, and takes exception to, thus easily misses best occasion for the treatment.Particularly regrettably, a lot of doctor is also easily mistaken diagnosis to this, until when there is typical lower limbs edema, not only can bring difficulty to treatment, also easily leave sequela.
AtractylenolideⅢ (atractylodes lactone 3), another name atractyloide III, English name Atractylenolide-III, molecular formula C
15h
20o
3, molecular weight: 248.32, its structural formula is as follows
AtractylenolideⅢ derives from the extract of feverfew Rhizoma Atractylodis Macrocephalae Atractylodes macrocephala Koidz. dry root.In the research of prior art, atractylenolideⅢ has antiinflammatory, antineoplastic action, and this composition also has the function regulating gastrointestinal motility and promote absorption of nutrient ingredients.
Summary of the invention
The object of the invention is to solve the deficiencies in the prior art, provide a kind of composition simple, and the medicine with antiplatelet aggregation of extract combination by the effective ingredient of natural medicinal raw material or the effective ingredient of its medicinal raw material.This medicine has good effect, has no side effect, and not easily produces drug resistance, taking convenience, is generally applicable to by the too high problem such as hyperlipidemia and thrombosis caused of platelet aggregation rate.
The present invention first aspect is to provide a kind of medicine of antiplatelet aggregation, comprises the atractylenolideⅢ derivant as shown in structural formula 1:
The medicine of antiplatelet aggregation of the present invention, preferably, described dosage form can be any one or a few in gastrointestinal administration dosage form, injecting medicine-feeding form, respiratory tract administration dosage form, percutaneous drug delivery dosage form, mucosa delivery dosage form, cavity/canal drug administration dosage form.
The medicine of antiplatelet aggregation of the present invention, preferably, described through gastrointestinal administration dosage form be selected from powder, tablet, granule, capsule, solution, Emulsion, suspensoid any one or a few.
The medicine of antiplatelet aggregation of the present invention, preferably, injecting medicine-feeding form be selected from intravenous injection, intramuscular injection, subcutaneous injection, intradermal injection and intracavitary administration any one or a few.
The medicine of antiplatelet aggregation of the present invention, preferably, described respiratory tract administration dosage form be selected from spray, aerosol, powder spray any one or a few.
The medicine of antiplatelet aggregation of the present invention, preferably, described percutaneous drug delivery dosage form be selected from solution, lotion, liniment, ointment, plaster, paste, patch any one or a few.
The medicine of antiplatelet aggregation of the present invention, preferably, described R1 be selected from substituents any one: hydrogen; The alkyl of the C1-C10 of straight chain or branching.
The medicine of antiplatelet aggregation of the present invention, preferably, described R2 be selected from substituents any one: hydrogen; The alkyl of the C1-C10 of straight chain or branching.
The medicine of antiplatelet aggregation of the present invention, preferably, the alkyl of described C1-C10 is more preferably the alkyl of C1-C8, be more preferably the alkyl of C1-C6, as methyl, ethyl, n-pro-pyl, isopropyl, normal-butyl, isobutyl group, the tert-butyl group, n-pentyl, isopentyl, n-hexyl, isohesyl.
Wherein, described alkyl can be straight chained alkyl or branched-alkyl, is more preferably straight chained alkyl.
The medicine of antiplatelet aggregation of the present invention, preferably, also comprises the second active component.
The medicine of antiplatelet aggregation of the present invention, preferably, the second active component be have in the Chinese medicine of antiplatelet aggregation and Western medicine any one or a few.
The medicine of antiplatelet aggregation of the present invention, preferably, described second active component to be selected from heparin, warfarin, aspirin, dipyridamole, prostacyclin, Ticlopidine, persantin, fenflumizole, sulfinpyrazone any one or a few.
The medicine of antiplatelet aggregation of the present invention, preferably, described second active component is selected from chuanxiong, Flos Carthami, Radix Paeoniae Rubra, Oletum Trogopterori, BOHUANG, Radix Angelicae Sinensis, ferulic acid, Rhizoma Chuanxiong, ligustrazine, Radix Salviae Miltiorrhizae, danshensu, Radix Curcumae essence, Radix Paeoniae Rubra 801, in compound ginseng-astragalus, Herba Artemisiae Anomalae, Rhizoma Sparganii, Radix Angelicae Pubescentis, Radix Glycyrrhizae Preparata, Pollen Typhae, Fructus Evodiae, Bulbus Allii, Bulbus Allii Cepae, Radix Curcumae, Herba Leonuri, Auricularia, Radix Puerariae, Radix Notoginseng, Caulis Spatholobi, Sanguis Draxonis, Radix Ilicis Pubescentis, Folium Ginkgo, Herba Erigerontis, kadsurenone any one or a few.
The medicine of antiplatelet aggregation of the present invention, preferably, mixes described medicine with described pharmaceutically acceptable adjuvant.
The medicine of antiplatelet aggregation of the present invention, preferably, described adjuvant is selected from solvent, propellant, solubilizing agent, cosolvent, emulsifying agent, coloring agent, adhesive, disintegrating agent, filler, lubricant, wetting agent, osmotic pressure regulator, stabilizing agent, fluidizer, correctives, antiseptic, suspending agent, coating material, aromatic, anti-adhesive, integrated agent, penetration enhancer, pH value regulator, buffer agent, plasticizer, surfactant, foaming agent, defoamer, thickening agent, inclusion agents, wetting agent, absorbent, diluent, flocculating agent and deflocculant, filter aid, release blocker in any one or a few.
The present invention second aspect is to provide the application of a kind of atractylenolideⅢ derivant in the medicine preparing antiplatelet aggregation, preferably, for the preparation of the medicine of the relevant disease of the too high initiation of antiplatelet aggregation rate.
Wherein, shown in described atractylenolideⅢ derivant structural formula 1 described above.
The application of atractylenolideⅢ derivant in the medicine preparing antiplatelet aggregation, preferably, for the preparation of the medicine of control hyperlipidemia, heart infarction, cerebral infarction.
Beneficial effect of the present invention:
The invention provides a kind of composition simple, and the medicine with the too high initiation relevant disease for the treatment of agglutinate rate of blood platelet generated by the extract of the effective ingredient of natural medicinal raw material or the effective ingredient of its medicinal raw material, and the preparation method of medicine and purposes, there is good effect, have no side effect, not easily produce drug resistance, taking convenience, can generally be applicable to by the too high related disorder patients caused of platelet aggregation rate.
The invention provides a kind for the treatment of by the medicine of the relevant disease of the too high initiation of platelet aggregation rate and Preparation method and use, its medicine is the extract of effective ingredient, take without the need to decocting, be easy to carry after being prepared into tablet, capsule, pill, granule, oral liquid, be convenient to preserve, and take easily, do not find any side effect when normal dose is taken.
The invention provides a kind for the treatment of by the medicine of the relevant disease of the too high initiation of platelet aggregation rate and Preparation method and use, there is the good property taken into account, except having good curative effect to the relevant disease of the too high initiation of the platelet aggregation rate such as hyperlipidemia, thrombosis, also have antiinflammatory, antitumor and there is the function regulating gastrointestinal function and promote absorption of nutrient ingredients.
Accompanying drawing explanation
Fig. 1 is atractylenolideⅢ antiplatelet aggregation experimental result;
Fig. 2 is the impact that atractylenolideⅢ is sprawled platelet;
The experimental result of Western blotting of Fig. 3 for testing described in Fig. 1;
The experimental result of Western blotting of Fig. 4 for testing described in Fig. 1
Fig. 5 is the contrast and experiment of atractylenolideⅢ and aspirin antiplatelet aggregation in vitro.
Detailed description of the invention
Below in conjunction with embodiment, technical scheme of the present invention is described in further detail.
When R1, R2 are methyl, be atractylenolideⅢ, its structural formula is
The present invention is verified below by concrete pharmacy test:
One, test material prepares
AtractylenolideⅢ, is dissolved in DMSO.
Two, experimental verification process
1. platelet aggregation test
(1) prepare platelet: the high concentration thrombocyte plasma in people source, preparation platelet count is 3 × 10
8/ mL, is placed in 37 DEG C of water-baths.
(2) the Concentraton gradient of atractylenolideⅢ compound: in 300uL platelet, the final concentration of compound is respectively 0.1 μm, 0.5 μm, 1 μm, 5 μm, 10 μm.
Experiment starts front compound and hatch 3min in platelet, arranges resting, DMSO in contrast in experiment.Use thrombin as stimulant.Obtained by platelet aggregation instrument and assemble curve and aggregation rate.
Experimental technique document:
Weng Z,Li D,Zhang L,et al.PTEN regulates collagen-induced platelet activation.Blood.2010；116(14):2579-2581.
Liu J,Jackson CW,Gruppo RA,Jennings LK,Gartner TK.The beta3suunit of the integrin alphallbbeta3regulates alphaIIb-mediated outside-in signaling.Blood.2005；105(11):4345-4352.
(3) experimental result (see accompanying drawing 1):
Show from above experimental result: atractylenolideⅢ has inhibitory action to platelet aggregation, and the atractylenolideⅢ inhibitory action of high concentration is obvious.
2. platelet sprawls experiment
(1) prepare platelet: the same, preparation platelet is 3 × 10
7/ mL.
(2) the Concentraton gradient of atractylenolideⅢ compound: in every 100uL platelet, the final concentration of compound is respectively 1 μM, 5 μMs, 10 μMs.Compound hatches 3min in platelet.The platelet that drug treating is crossed is layered on (40 μ g/mL) on fibrin.By fluorescent antibody phalloidin, at 100X oil, Microscopic observation is hematoblastic sprawls situation.
Experimental technique document:
Chen X,Zhang Y,Wang Y,et al.PDK1regulates platelet activation and arterial thrombosis.Blood.2013；121(18):3718-3726.
(3) experimental result (see accompanying drawing 2): illustrate that atractylenolideⅢ has sprawled impact to platelet.
③Western blotting
After curve is assembled in acquisition, collect blood platelet albumen sample (2 × SDS loading protein lysate), detected the phosphorylation level of correlation molecule by Western blotting.
Experimental result (see accompanying drawing 3, accompanying drawing 4) is as follows:
By the phosphorylation level of the correlation molecule of western blooting detection signal path, when PI3K/Akt signal path is activated, then Akt molecule generation phosphorylation activation, thus the enzyme, kinases, transcription factor etc. (as GSK3) in downstream are activated, platelet activation finally can be made to assemble, if and the phosphorylation level of Akt molecule is higher, then platelet aggregation degree is higher.Experimental result shows: atractylenolideⅢ affects the phosphorylation level of Akt molecule, and the impact of its concentration change on Akt molecule phosphorylation level is consistent with on the impact of platelet aggregation degree.
4. aspirin In Vitro Anti platelet aggregation test
(1) prepare platelet: the same, preparation platelet is 3 × 10
8/ mL;
(2) aspirin is dissolved in dehydrated alcohol, being diluted to concentration is 50mmol/L, uses thrombin
Stimulant stimulates, and observes platelet aggregation situation.
Experimental result (see accompanying drawing 5) is as follows:
In the experiment in vitro of the same terms, aspirin thombin stimulate under, concentration up to still unrestraint effect during 150uM, and atractylenolideⅢ test in vitro in low concentration (10uM) namely have anticoagulant effect.
Be described in detail specific embodiments of the invention above, but it is just as example, the present invention is not restricted to specific embodiment described above.To those skilled in the art, any equivalent modifications that the present invention is carried out and substituting also all among category of the present invention.Therefore, equalization conversion done without departing from the spirit and scope of the invention and amendment, all should contain within the scope of the invention.
Claims (10)
1. a medicine for antiplatelet aggregation, is characterized in that, comprises the atractylenolideⅢ derivant as shown in structural formula 1:
Wherein, described R1, R2 are separately selected from any one in substituents: hydrogen; The alkyl of the C1-C10 of straight or branched.
2. the medicine of a kind of antiplatelet aggregation according to claim 1, it is characterized in that, R1 and R2 is respectively methyl.
3. the medicine of a kind of antiplatelet aggregation according to claim 1, it is characterized in that, described dosage form be selected from gastrointestinal administration dosage form, injecting medicine-feeding form, respiratory tract administration dosage form, percutaneous drug delivery dosage form, mucosa delivery dosage form, cavity/canal drug administration dosage form any one or a few.
4. the medicine of a kind of antiplatelet aggregation according to claim 1, is characterized in that, also comprises the second active component, the second active component be have in the Chinese medicine of antiplatelet aggregation and Western medicine any one or a few.
5. the medicine of a kind of antiplatelet aggregation according to claim 4, it is characterized in that, described Western medicine be selected from heparin, warfarin, aspirin, dipyridamole, prostacyclin, Ticlopidine, persantin, fenflumizole, sulfinpyrazone any one or a few.
6. the medicine of a kind of antiplatelet aggregation according to claim 4, it is characterized in that, described Chinese medicine is selected from Rhizoma Chuanxiong, Flos Carthami, Radix Paeoniae Rubra, Oletum Trogopterori, BOHUANG, Radix Angelicae Sinensis, ferulic acid, Rhizoma Chuanxiong, ligustrazine, Radix Salviae Miltiorrhizae, danshensu, Radix Curcumae essence, in compound ginseng-astragalus, Herba Artemisiae Anomalae, Rhizoma Sparganii, Radix Angelicae Pubescentis, Radix Glycyrrhizae Preparata, Pollen Typhae, Fructus Evodiae, Bulbus Allii, Bulbus Allii Cepae, Radix Curcumae, Herba Leonuri, Auricularia, Radix Puerariae, Radix Notoginseng, Caulis Spatholobi, Sanguis Draxonis, Radix Ilicis Pubescentis, Folium Ginkgo, Herba Erigerontis, kadsurenone any one or a few.
7. the medicine of a kind of antiplatelet aggregation according to claim 1, is characterized in that, also comprises and mixing with described pharmaceutically acceptable adjuvant.
8. the medicine of a kind of antiplatelet aggregation according to claim 7, it is characterized in that, described adjuvant is selected from solvent, propellant, solubilizing agent, cosolvent, emulsifying agent, coloring agent, adhesive, disintegrating agent, filler, lubricant, wetting agent, osmotic pressure regulator, stabilizing agent, fluidizer, correctives, antiseptic, suspending agent, coating material, aromatic, anti-adhesive, integrated agent, penetration enhancer, pH value regulator, buffer agent, plasticizer, surfactant, foaming agent, defoamer, thickening agent, inclusion agents, wetting agent, absorbent, diluent, flocculating agent and deflocculant, filter aid, release blocker in any one or a few.
9. the application of atractylenolideⅢ derivant in the medicine preparing antiplatelet aggregation shown in structural formula 1,
Wherein, described R1, R2 are separately selected from any one in substituents: hydrogen; The alkyl of the C1-C10 of straight or branched.
10. application according to claim 9, is characterized in that, for the preparation of the medicine of control hyperlipidemia, pulmonary infarction, heart infarction, cerebral infarction.
Priority Applications (6)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201410752500.0A CN104490869B (en) | 2014-12-09 | 2014-12-09 | III derivative of atractylodes lactone is in the drug for preparing application and anti-platelet aggregation in anti-platelet aggregation drug |
| PCT/CN2015/076743 WO2016090800A1 (en) | 2014-12-09 | 2015-04-16 | Application of atractylenolide compound or derivative thereof and anti-platelet aggregation drug |
| US14/908,089 US9642832B2 (en) | 2014-12-09 | 2015-04-16 | Use of atractylenolide compound or its derivatives and a medicament for inhibiting platelet aggregation |
| EP15868066.0A EP3231422B1 (en) | 2014-12-09 | 2015-04-16 | Application of atractylenolide compound or derivative thereof and anti-platelet aggregation drug |
| CN201580067226.6A CN107106538A (en) | 2014-12-09 | 2015-04-16 | The application of atractylodes lactone class compound or derivatives thereof and anti-platelet aggregation medicine |
| JP2017549568A JP2018507907A (en) | 2014-12-09 | 2015-04-16 | Application of atractylenolide compound or derivative thereof and platelet aggregation inhibitor |
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| CN201410752500.0A CN104490869B (en) | 2014-12-09 | 2014-12-09 | III derivative of atractylodes lactone is in the drug for preparing application and anti-platelet aggregation in anti-platelet aggregation drug |
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| CN104490869A true CN104490869A (en) | 2015-04-08 |
| CN104490869B CN104490869B (en) | 2019-05-31 |
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2016090800A1 (en) * | 2014-12-09 | 2016-06-16 | 上海交通大学医学院附属第三人民医院 | Application of atractylenolide compound or derivative thereof and anti-platelet aggregation drug |
| CN110507650A (en) * | 2019-10-12 | 2019-11-29 | 郑州大学第一附属医院 | Application of the Rhizoma Atractylodis Macrocephalae lactams in terms of preparing antithrombotic reagent |
| CN110638755A (en) * | 2019-10-29 | 2020-01-03 | 江苏盈科生物制药有限公司 | Propofol medium-long chain fat emulsion and preparation method thereof |
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| CN102133222A (en) * | 2011-01-14 | 2011-07-27 | 广东药学院 | Compound Chinese medicine extract preventing arteriosclerosis and preparation method thereof |
| JP2013234177A (en) * | 2012-04-12 | 2013-11-21 | Kracie Seiyaku Kk | Cell death-inhibiting composition |
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Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102133222A (en) * | 2011-01-14 | 2011-07-27 | 广东药学院 | Compound Chinese medicine extract preventing arteriosclerosis and preparation method thereof |
| JP2013234177A (en) * | 2012-04-12 | 2013-11-21 | Kracie Seiyaku Kk | Cell death-inhibiting composition |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2016090800A1 (en) * | 2014-12-09 | 2016-06-16 | 上海交通大学医学院附属第三人民医院 | Application of atractylenolide compound or derivative thereof and anti-platelet aggregation drug |
| CN110507650A (en) * | 2019-10-12 | 2019-11-29 | 郑州大学第一附属医院 | Application of the Rhizoma Atractylodis Macrocephalae lactams in terms of preparing antithrombotic reagent |
| CN110638755A (en) * | 2019-10-29 | 2020-01-03 | 江苏盈科生物制药有限公司 | Propofol medium-long chain fat emulsion and preparation method thereof |
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