CN115531484A - 一种用于治疗IgA肾病的中药组合物及其制备方法 - Google Patents
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Abstract
本发明提供了一种用于治疗IgA肾病的中药组合物及其制备方法,属于中药组合物技术领域。本发明所述中药组合物包括生地、黄芪、石莲子、党参、地骨皮、麦冬、车前子、茯苓、黄芩、猪苓、益母草、柴胡、白花蛇舌草、半枝莲、青风藤、鬼箭羽、炙甘草。本发明还提供了该中药组合物的制备方法,包括:按所述原料配比称取原料药,加水煎煮,过滤得到药液。本发明提供的组合物药性平和、清心火、益气阴,无毒副作用,可有效减少血尿、蛋白尿及药物不良反应,用于慢性肾小球肾炎(IgA肾病)的治疗。
Description
技术领域
本发明属于中药组合物技术领域,尤其涉及一种用于治疗IgA肾病的中药组合物及其制备方法。
背景技术
IgA肾病,又称为系膜增生性IgA肾病,其特征性的改变是免疫球蛋白IgA广泛沉积于肾小球的系膜区,部分患者会伴有IgG和IgM的沉积,是常见的原发性肾小球疾病。IgA肾病的临床表现形式多样,可以发生于不同的人群,表现为肉眼血尿、镜下血尿及蛋白尿、肾病综合征、急性肾衰、慢性肾衰及高血压等。
现代医学对于IgA肾病大多采用ACEI/ARB、激素以及免疫抑制药物、抗感染、利尿等方案治疗,但疗效欠佳。对于快速进展型IgA肾病,常给予激素和免疫抑制剂治疗为主,但激素和免疫抑制剂存在毒副作用,而且并不改善病人的预后;对于24h尿蛋白>0.5g者,常以ACEI/ARB类药物为主;对于单纯性血尿者仅以对症治疗为主,缺乏有效手段。中医认为上述药物可耗气伤阴、易引起肝肾损伤等方面的毒副作用。尤其糖皮质激素及免疫抑制剂,长期应用,“下丘脑-垂体-肾上腺皮质”轴被反馈抑制,出现免疫力降低、感染、库欣综合征等各种副作用和并发症,临床常表现为经常汗出、乏力口干、五心烦热等气阴两虚证候。
IgA肾病多归属于中医领域中“水肿”、“尿血”、“腰痛”、“肾风”等范畴。本虚标实是其基本病机,临床上多见本病表现为脏腑虚损,尤以脾肾亏虚为主,水湿、湿热、风邪、瘀血等为病变之标,为虚实夹杂之证。通过多中心流行病学调查,随着病理损伤加重,中医证型由脾肺气虚证、气阴两虚证,转化为肝肾阴虚证、脾肾阳虚证,气阴两虚证是最常见的证型,也是IgA肾病从低危向高危发展的关键拐点。
因此,如何从中医领域出发,寻找到一种有效治疗IgA肾病气阴两虚证的有效中药方剂成为本领域需要解决的一个技术问题。
发明内容
有鉴于此,本发明的目的在于提供一种用于治疗IgA肾病的气阴两虚证的中药组合物及其制备方法,对IgA肾病及其相关并发症具有显著的治疗效果。
为了实现上述发明目的,本发明提供了以下技术方案:
本发明提供了一种用于治疗IgA肾病的中药组合物,所述中药组合物按质量份数计,包括:生地黄15~25份、黄芪25~35份、石莲子15~25份、党参25~35份、地骨皮10~20份、麦冬15~25份、车前子15~25份、茯苓10~20份、黄芩10~15份、猪苓15~25份、益母草25~35份、柴胡5~15份、白花蛇舌草25~35份、半枝莲10~20份、青风藤10~20份、鬼箭羽10~20份、炙甘草3~10份。
优选的,所述中药组合物按质量份数计,包括:生地黄18~22份、黄芪28~32份、石莲子18~23份、党参27~32份、地骨皮13~18份、麦冬18~22份、车前子18~23份、茯苓13~17份、黄芩11~13份、猪苓18~23份、益母草28~32份、柴胡8~12份、白花蛇舌草28~31份、半枝莲12~16份、青风藤12~17份、鬼箭羽13~17份、炙甘草4~7份。
优选的,所述中药组合物按质量份数计,包括:生地20份、黄芪30份、石莲子20份、党参30份、地骨皮15份、麦冬20份、车前子20份、茯苓15份、黄芩12份、猪苓20份、益母草30份、柴胡10份、白花蛇舌草30份、半枝莲15份、青风藤15份、鬼箭羽15份、炙甘草5份。
本发明还提供了上述中药组合物的制备方法,包括以下步骤:按所述原料配比称取原料药,加水煎煮,过滤得到药液。
优选的,所述加水量为原料药质量的6~10倍。
优选的,加水煎煮2~3次,每次煎煮1~2h。
优选的,药液浓缩至相对密度为1.20~1.25的清膏,加入辅料制成相应的中药复方剂型。
优选的,所述中药复方剂型包括颗粒剂、丸剂、膏剂、片剂。
本发明还提供了上述中药组合物在IgA肾病及其相关并发症制药中的应用。
本发明还提供了上述中药组合物在IgA肾病气阴两虚证制药中的应用。
本发明的有益效果:
本发明以中医理论为指导,以确凿的临床实践为基础,以现代科学研究方法为手段,以益气养阴,通络利湿为治则,用于IgA肾病的治疗。
本发明提供的中药组合物能够补肾涩精,益气阴,利湿浊,祛风通络,可有效减少血尿、蛋白尿及药物不良反应。本发明提供的中药组合物药性温平,不冷不热,常服清心养神,秘精补虚,滋润肠胃,调顺血,可用于IgA肾病的治疗。与同类药物比较,本发明组方中医理论依据充分,药性平和,配伍严谨,药效学物质清楚,临床疗效显著,在三个月内均能取得良好的疗效。
具体实施方式
本发明提供了一种用于治疗IgA肾病的中药组合物,所述中药组合物按质量份数计,包括:生地黄15~25份、黄芪25~35份、石莲子15~25份、党参25~35份、地骨皮10~20份、麦冬15~25份、车前子15~25份、茯苓10~20份、黄芩10~15份、猪苓15~25份、益母草25~35份、柴胡5~15份、白花蛇舌草25~35份、半枝莲10~20份、青风藤10~20份、鬼箭羽10~20份、炙甘草3~10份。
优选的,所述中药组合物按质量份数计,包括:生地黄18~22份、黄芪28~32份、石莲子18~23份、党参27~32份、地骨皮13~18份、麦冬18~22份、车前子18~23份、茯苓13~17份、黄芩11~13份、猪苓18~23份、益母草28~32份、柴胡8~12份、白花蛇舌草28~31份、半枝莲12~16份、青风藤12~17份、鬼箭羽13~17份、炙甘草4~7份。
更优选的,所述中药组合物按质量份数计,包括:生地黄20份、黄芪30份、石莲子20份、党参30份、地骨皮15份、麦冬20份、车前子20份、茯苓15份、黄芩12份、猪苓20份、益母草30份、柴胡10份、白花蛇舌草30份、半枝莲15份、青风藤15份、鬼箭羽15份、炙甘草5份。
本发明提供中药组方中主要药物介绍如下:
生地黄,为玄参科地黄属植物地黄的新鲜或干燥块根。具有清热凉血,养阴生津的功效。主治热入营血,舌绛烦渴,斑疹吐衄,阴虚内热,骨蒸劳热,津伤口渴,内热消渴,肠燥便秘。
黄芪,为豆科黄芪属植物蒙古黄或膜荚黄芪的根。具有健脾补中,升阳举陷,益卫固表,利尿,托毒生肌的功效。主治脾气虚证,肺气虚证,气虚自汗证,气血亏虚,疮疡难溃难腐,或溃久难敛等。
石莲子,为睡莲科植物莲的老熟的果实。具有清湿热,开胃进食,清心宁神,涩精止泄之功效。常用于噤口痢,呕吐不食,心烦失眠,遗精,尿浊,带下。
党参,为桔梗科党参属植物党参、素花党参或川党参的根。具有补脾益肺,生津养血的功效。主治脾胃虚弱,肺虚喘咳,津伤口渴,血虚体弱等。
地骨皮,为茄科枸杞属植物枸杞或宁夏枸杞的干燥根皮。具有凉血除蒸,清肺降火的功效。主治阴虚发热、盗汗骨蒸,肺热咳嗽,血热出血等。
麦冬,百合科沿阶草属多年生常绿草本植物。具有生津解渴、润肺止咳的功效。主治肺燥干咳、阴虚痨嗽、喉痹咽痛、津伤口渴、内热消渴、心烦失眠、肠燥便秘等症。
车前子,为车前科车前属植物车前或平车前的干燥成熟种子。具有清热利尿,渗湿止泻,明目,祛痰的功效。主治小便不利,淋浊带下,水肿胀满,暑湿泻痢,目赤障翳,痰热咳喘。
茯苓,为多孔菌科卧孔属真菌茯苓的干燥菌核。具有利水消肿,渗湿,健脾,宁心的功效。主治水肿,痰饮,脾虚泄泻,心悸,失眠。
黄芩,为唇形科黄芩属植物黄芩的干燥根。具有清热燥湿,泻火解毒,止血,安胎的功效。主治湿温,暑湿,胸闷呕恶,湿热痞满,黄疸泻痢,肺热咳嗽,高热烦渴,血热吐衄,胎动不安。
猪苓,为多孔菌科多孔菌属真菌猪苓的干燥菌核。具有利水消肿,渗湿的功效。主治水肿,小便不利,脚气,泄泻,淋浊,带下等。
益母草,为唇形科益母草属植物益母草的新鲜或干燥地上部分。具有活血调经,利尿消肿,清热解毒的功效。主治月经不调,痛经经闭,恶露不尽,水肿尿少,疮疡肿毒。
柴胡,为伞形科柴胡属植物柴胡或狭叶柴胡的干燥根。具有解表退热,疏肝解郁,升举阳气的功效。主治表证发热,少阳证,肝郁气滞,气虚下陷,脏器脱垂,退热截疟。
白花蛇舌草,为茜草科耳草属植物白花蛇舌草的全草。具有清热解毒,利湿通淋的功效。主治痈肿疮毒,咽喉肿痛,毒蛇咬伤,热淋涩痛。
半枝莲,为唇形科植物半枝莲的全草。具有清热解毒,散瘀止血,利尿消肿的功效。主治热毒痈肿,咽喉疼痛,肺痈,肠痈,瘰疬,毒蛇咬伤,跌打损伤,吐血,衄血,血淋,水肿,腹水及癌症。
青风藤,为防己科防己属植物青藤和毛青藤的干燥藤茎。具有祛风湿,通经络,利小便的功效。用于风湿痹痛,关节肿胀,麻痹瘙痒。
鬼箭羽,为卫矛科植物卫矛的具翅状物枝条或翅状附属物。具有破血通经,解毒消肿,杀虫之功效。用于症瘕结块,心腹疼痛,闭经,痛经,崩中漏下,产后瘀滞腹痛,恶露不下,疝气,历节痹痛,疮肿,跌打伤痛,虫积腹痛,烫火伤,毒蛇咬伤。
炙甘草,为甘草的一种炮制品,是甘草加炼蜜炒制而成,同样具有补、泻、缓、和的作用,但是炙甘草的应用多取其补、缓、和的特点,益气的作用强于甘草。
在本发明所述方剂中,遵从君臣佐使的用药规律,本方剂中以黄芪和生地黄益气养阴为君药;党参补气升阳,莲子养脾阴,清心火,地骨皮,麦冬滋阴,此四味药共为臣药;柴胡、黄芩既能疏散肝胆之郁热,又能清上焦心肺之热,肺热清则清肃下行;白花蛇舌草、半枝莲清热解毒;青风藤、鬼箭羽,益母草祛风通络,共为佐药;茯苓,猪苓,车前子,清利湿热,使热邪从小便而解,炙甘草甘缓和中共为使药。
本发明还提供了上述中药组合物的制备方法,所述制备方法包括以下步骤:按所述原料配比称取原料药,加水煎煮,过滤得到药液。
本发明按照上述原料配比分别称取原料药,加6~10倍质量的水,使原料药完全浸泡在水中。优选的,本发明加水量为原料药7~9倍,更优选为8倍。优选的,本发明的水为凉白开水或纯净水。
本发明对原料药和水直接进行煎煮。本发明所述煎煮条件为:加水煎煮2~3次,每次煎煮1~2h。作为一种可选的实施方式,本发明在自然压力下,加水煎煮1.5小时,过滤得到药液,药渣采用上述煎煮步骤重复煎煮1~2次,煎液滤过,合并滤液,即为所得药液。
本发明将所得药液浓缩至相对密度为1.20~1.25(60℃)的清膏,加入辅料制成相应的中药复方剂型。本发明对具体的中药剂型不做限定,所述剂型包括但不限于颗粒剂、丸剂、膏剂、片剂。
作为一种可选的实施方式,本发明将上述中药组合物制备得到颗粒剂:在所得清膏中加入适量辅料,制成软材,过14目筛,制成湿颗粒,干燥,整粒,制成颗粒剂成品。
本发明制备的中药复方药剂具有益气养阴,通络利湿功效。
本发明所述适应症:用于气阴两虚所致倦怠乏力、少气懒言、腰膝酸软、头晕心悸、食少纳差、口干舌燥、五心烦热、自汗、盗汗,舌淡或淡红,质胖大边有齿痕,少苔偏干,脉沉细或细数而无力等;慢性肾炎、肾病综合征、尿路感染、蛋白尿见上述证候者。
本发明所述中药组合物用法用量为:口服,1次15g,一日2次。30天一个疗程(具体可根据临床情况改变)。
本发明还提供了上述中药组合物在IgA肾病及其相关并发症制药中的应用。本发明还提供了上述中药组合物在IgA肾病气阴两虚证制药中的应用经多年临床观察治疗,不同病因症状的IgA肾病患者有效率可达95%以上,具有显著疗效。
下面结合实施例对本发明提供的技术方案进行详细的说明,但是不能把它们理解为对本发明保护范围的限定。
实施例1
一种治疗IgA肾病的中药组合物,所述中药组合物按重量份计,为:生地黄20g、黄芪30g、石莲子20g、党参30g、地骨皮15g、麦冬20g、车前子20g、茯苓15g、黄芩12g、猪苓20g、益母草30g、柴胡10g、白花蛇舌草30g、半枝莲15g、青风藤15g、鬼箭羽15g、炙甘草5g。
按照上述原料配比分别称取原料药,加8倍量水,自然压力下,煎煮3次,每次1.5小时,煎液滤过,合并滤液,浓缩至相对密度为1.20~1.25(60℃)的清膏,加入适量淀粉:糊精(1:1)作为辅料,制成软材,过14目筛,制成湿颗粒,干燥,整粒,制成颗粒剂成品。
实施例2
一种治疗IgA肾病的中药组合物,所述中药组合物按重量份计,为:生地黄18g、黄芪28g、石莲子19g、党参29g、地骨皮16g、麦冬19g、车前子18g、茯苓19g、黄芩13g、猪苓17g、益母草28g、柴胡11g、白花蛇舌草31g、半枝莲14g、青风藤13g、鬼箭羽16g、炙甘草4g。
按照上述原料配比分别称取原料药,加9倍量水,自然压力下,煎煮2次,每次2小时,煎液滤过,合并滤液,浓缩至相对密度为1.20~1.25(60℃)的清膏,加入适量淀粉:糊精(1:1)作为辅料,制成软材,过14目筛,制成湿颗粒,干燥,整粒,制成颗粒剂成品。
实施例3
一种治疗IgA肾病的中药组合物,所述中药组合物按重量份计,为:生地黄22g、黄芪25g、石莲子20g、党参31g、地骨皮14g、麦冬20g、车前子21g、茯苓15g、黄芩13g、猪苓20g、益母草31g、柴胡9g、白花蛇舌草30g、半枝莲16g、青风藤15g、鬼箭羽15g、炙甘草3g。
按照上述原料配比分别称取原料药,加7倍量水,自然压力下,煎煮3次,每次2小时,煎液滤过,合并滤液,浓缩至相对密度为1.20~1.25(60℃)的清膏,加入适量淀粉:糊精(1:1)作为辅料,制成软材,过14目筛,制成湿颗粒,干燥,整粒,制成颗粒剂成品。
实施例4
一种治疗IgA肾病的中药组合物,所述中药组合物按重量份计,为:生地黄21g、黄芪30g、石莲子20g、党参30g、地骨皮16g、麦冬21g、车前子20g、茯苓14g、黄芩12g、猪苓21g、益母草29g、柴胡10g、白花蛇舌草31g、半枝莲18g、青风藤16g、鬼箭羽16g、炙甘草8g。
制备方法同实施例1。
实施例5
一种治疗IgA肾病的中药组合物,所述中药组合物按重量份计,为:生地黄20g、黄芪30g、石莲子16g、党参25g、地骨皮10g、麦冬16g、车前子21g、茯苓14g、黄芩15g、猪苓15g、益母草26g、柴胡10g、白花蛇舌草30g、半枝莲10g、青风藤10g、鬼箭羽11g、炙甘草7g。
制备方法同实施例1。
实施例6
在本实施例中,采用实施例1制备得到的颗粒剂进行临床实验。
1、疾病诊断
参照《肾脏病学》:肾脏病理免疫荧光明确IgA或以IgA为主的免疫复合物在肾小球系膜区弥漫沉积;临床表现为畸形红细胞为主的血尿,可伴或不伴不同程度的蛋白尿、高血压、肾功能损害;排除继发性因素。
2、中医证候诊断标准:(参照《中药新药临床研究指导原则》)。《IgA肾病西医诊断和中医辨证分型的实践指南》
主症:气短乏力,盗汗、自汗,腰膝酸软,手足心热。
次症:口干、神疲。
舌脉:舌淡或淡红,质胖大边有齿痕,少苔偏干,脉沉细或细数而无力。
3、纳入标准
(1)经肾穿刺活检明确诊断为IgA肾病且无新月体形成,24小时尿蛋白定量<3.5g,并且eGFR(肾小球滤过率)≥30ml/min/1.73m2;
(2)规范采集了中医证候信息,并符合气阴两虚证;
(3)自愿参加本项研究,并签署知情同意书。
4、排除标准
(1)开始治疗时已进展至终末期肾病的患者;
(2)合并糖尿病、类风湿关节炎、干燥综合症、慢性病毒性肝炎、血管炎肾损害、狼疮性肾炎等系统性疾病的患者;
(3)已知对研究用药所含成分过敏者,或过敏体质患者;
(4)合并有严重的呼吸、消化、血液系统等原发疾病以及目前并发感染及精神病者,合并充血性心功能衰竭I-IV级者;或者发现恶性肿瘤患者及妊娠、哺乳者;6个月内有恶性高血压、心肌梗死、脑血管意外和糖尿病酮症酸中毒等危急重症病史者;
(5)临床研究者认为参与临床研究的被试者不能配合观察时。
5、研究方法
根据纳排标准入组患者,按照随机数字表分为中药组及对照组,两组均给予基础治疗。基础治疗包括低盐低脂优质蛋白饮食,优质蛋白摄入量约0.8g/kg/d。应用超过6个月足量ACEI治疗。合并其他情况:伴有难以纠正的高血压者在ACEI基础上,加用CCB类药物。中药组除基础治疗外,给予本发明实施例1制剂治疗,口服,1次15g,一日2次。评估疗效性评价指标,包括中医证侯积分量表,并检查肾功、24小时尿蛋白定量、尿常规,估算肾小球滤过率,进行统计分析;评估安全性评价指标,包括血常规、肝功、肾功等,并统计分析。
6、疗效标准
6.1、中医证候疗效标准:参照中华人民共和国卫生部2002年制定颁布的《中药新药临床研究指导原则(试行)》。计算公式采用尼莫地平法。
计算公式:[〔治疗前积分-治疗后积分〕÷治疗前积分]×100%;
(1)临床痊愈:症状、体征消失或基本消失,证候积分减少≥95%;
(2)显效:症状、体征明显改善,证候积分减少≥70%;
(3)有效:症状、体征均有好转,证候积分减少≥30%;
(4)无效:症状、体征均无明显改善,甚或加重,证候积分减少<30%。
6.2、疾病综合疗效评价标准:(参考2007年制定的《IgA肾病的诊断、辨证分型和疗效评定(试行方案)》拟定的标准疗效评定标准)
(1)完全缓解:中医症候积分减少≥95%,尿沉渣镜检红细胞数<0.8万/ml或≤3个/高倍视野,24小时尿蛋白定量≤0.3g,肾功能正常;
(2)显效:中医症候积分减少≥70%,<95%,尿沉渣镜检红细胞数较前减少≥50%,24小时尿蛋白定量较前减少≥50%,肾功能正常;
(3)有效:中医症候积分减少≥30%,<70%,尿沉渣镜检红细胞数较前减少≥5%,<50%,24小时尿蛋白定量较前减少≥25%,<50%,肾功能正常;
(4)无效:中医症候积分减少<30%以及上述实验室指标均无明显改善或反加重者。
6.3、观察指标:
(1)中医证候积分方法:评分标准见表1。治疗前及结束时各观察记录一次。
表1症状评分标准
表中舌脉用于协助判断证型及兼夹证,不参与评分。
(2)其他观察指标:
人口学信息:性别、年龄、长期生活的地域、饮食、个人史、IgA肾病病史等。
体格检查信息:身高、体重、血压等指标。
安全性指标:观察治疗前后血常规、肝功、心电图等。
对中药组和对照组治疗90天后的治疗效果进行统计,见表2~6。
表2两组IgA肾病患者疗效及总有效率比较
注:与对照组比较,#P<0.01
由表2可见,与对照组比较,中药组总有效率显著增高,有统计学意义(P<0.01)
注:与对照组比较,#P<0.01
由表3可见,两组患者治疗后主要症状积分、次要症状积分均下降。经治疗后,与对照组比较,中药组主要症状、次要症状量化积分下降明显,有统计学意义(P<0.05)。
注:与治疗前比较,#P<0.05;与对照组比较,▲P<0.05
由表4可见,与治疗前比较,治疗后两组患者24小时尿蛋白定量、尿红细胞计数下降,有统计学意义(P<0.05)。治疗后,与对照组比较,中药组24小时尿蛋白定量、尿红细胞计数下降明显,有统计学意义(P<0.05)。
注:与治疗前比较,#P<0.05
注:与治疗前比较,#P<0.05
由表5、表6可见:与治疗前比较,治疗后对照组及中药组肾功能明显改善,肾小球滤过率升高,有统计学意义(P<0.05)。治疗后,与对照组比较,中药组肾功能、肾小球滤过率无明显差异。
实施例7
本实施例提供了典型病例,进一步说明本发明的疗效。
周某某,男,58岁,2021年02月20日初诊。主诉:间断双眼睑水肿7年,加重伴双下肢水肿1个月。现病史:患者7年前无明显诱因出现双眼睑水肿,每于劳累后发作,休息后可自行缓解,故未系统诊疗。1个月余前无明显诱因出现双眼睑水肿加重,伴双下肢水肿,水肿程度不对称,遂就诊于白城中心医院,查尿常规示:蛋白+3,隐血+3,红细胞计数179/u1,白细胞计数73/u1,肝功能示:总蛋白53g/L,白蛋白23g/L,肾功能示:125umo1/L,诊断为“肾病综合征”,口服中药及静点改善循环、利尿消肿药物治疗(具体不详),12天后复查相关理化检查示:尿常规:蛋白+2,潜血+3,红细胞计数316/ul,白细胞计数40/ul,肝功能示:白蛋白27g/L,肾功能示:169umol/L,为求中医药系统诊疗,就诊于我院。
现症:双眼脸及双下肢水肿,腰痛,偶有乏力,手足心热,尿频,夜尿2-3次,大便秘结,3-5天1行,纳眠可,时有右下肢麻木。既往史:有高血压病史1月余,血压最高达170/90mmHg;甲状腺功能减退症病史1月余;查体:舌质淡,苔白腻,脉沉滑,血压173/90mmHg。辅助检查:尿常规:尿蛋白+4,隐血+3,尿红细胞计数474.6/ul,尿红细胞85.4/HPF;血尿定位:非均一型红细胞70%;尿微量白蛋白9653mg/L;24小时尿蛋白15.65g,24小时尿量3.7L;肝功能:白蛋白25.4g/L;血脂:总胆固醇7.1mmol/L,甘油三酯2.7mmol/L;肾功:尿素氮11.5mmol/L,血肌酐141umol/L。肾穿病理:增生硬化型IgA肾病(Lee分级Ⅴ级)。
中医诊断:水肿病、气阴两虚证,西医诊断:IgA肾病。
治则:益气养阴、清热化湿。
方用:实施例1制备得到的颗粒剂,口服,一次15g,一日2次。
服用60日,二诊症见:双下肢水肿好转,仍乏力,手足心热好转,查体:舌淡红,苔白腻,脉沉。辅助检查:尿常规:尿蛋白+3,隐血+3,红细胞计数106/ul,红细胞(高倍视野)19.1/HPF;尿微量白蛋白3034.97mg/L;肾功:尿素氮9.9mmol/L,血肌酐104umol/L。
服用90日,三诊症见:患者眼睑及双下肢无浮肿,无乏力。查体:舌淡红,苔薄白,脉沉。辅助检查:尿常规:尿蛋白+3,隐血+3,红细胞计数192.9/ul,红细胞(高倍视野)34.7/HPF;尿微量白蛋白2477.89mg/L;肾功:尿素氮10.4mmol/L,血肌酐103umol/L。
继续服用半年后,复查尿常规:蛋白+2,隐血+1,红细胞6.7/HPF;尿微量白蛋白1318.79mg/L;生化:白蛋白35.1g/L,血肌酐111umol/L。
以上所述仅是本发明的优选实施方式,应当指出,对于本技术领域的普通技术人员来说,在不脱离本发明原理的前提下,还可以做出若干改进和润饰,这些改进和润饰也应视为本发明的保护范围。
Claims (10)
1.一种用于治疗IgA肾病的中药组合物,其特征在于,所述中药组合物按质量份数计,包括:生地黄15~25份、黄芪25~35份、石莲子15~25份、党参25~35份、地骨皮10~20份、麦冬15~25份、车前子15~25份、茯苓10~20份、黄芩10~15份、猪苓15~25份、益母草25~35份、柴胡5~15份、白花蛇舌草25~35份、半枝莲10~20份、青风藤10~20份、鬼箭羽10~20份、炙甘草3~10份。
2.根据权利要求1所述的中药组合物,其特征在于,所述中药组合物按质量份数计,包括:生地黄18~22份、黄芪28~32份、石莲子18~23份、党参27~32份、地骨皮13~18份、麦冬18~22份、车前子18~23份、茯苓13~17份、黄芩11~13份、猪苓18~23份、益母草28~32份、柴胡8~12份、白花蛇舌草28~31份、半枝莲12~16份、青风藤12~17份、鬼箭羽13~17份、炙甘草4~7份。
3.根据权利要求1所述的中药组合物,其特征在于,所述中药组合物按质量份数计,包括:生地20份、黄芪30份、石莲子20份、党参30份、地骨皮15份、麦冬20份、车前子20份、茯苓15份、黄芩12份、猪苓20份、益母草30份、柴胡10份、白花蛇舌草30份、半枝莲15份、青风藤15份、鬼箭羽15份、炙甘草5份。
4.权利要求1~3任意一项所述的中药组合物的制备方法,其特征在于,包括以下步骤:按所述原料配比称取原料药,加水煎煮,过滤得到药液。
5.根据权利要求4所述的制备方法,其特征在于,所述加水量为原料药质量的6~10倍。
6.根据权利要求4所述的制备方法,其特征在于,加水煎煮2~3次,每次煎煮1~2h。
7.根据权利要求4所述的制备方法,其特征在于,药液浓缩至相对密度为1.20~1.25的清膏,加入辅料制成相应的中药复方剂型。
8.根据权利要求7所述的制备方法,其特征在于,所述中药复方剂型包括颗粒剂、丸剂、膏剂、片剂。
9.权利要求1~3任意一项所述的中药组合物在IgA肾病及其相关并发症制药中的应用。
10.权利要求1~3任意一项所述的中药组合物在IgA肾病气阴两虚证制药中的应用。
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