CN115515579B - 吡咯并[2,3-b]吡啶-3-甲酰胺组合物和改善听力损失的方法 - Google Patents

吡咯并[2,3-b]吡啶-3-甲酰胺组合物和改善听力损失的方法

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Publication number
CN115515579B
CN115515579B CN202180019399.6A CN202180019399A CN115515579B CN 115515579 B CN115515579 B CN 115515579B CN 202180019399 A CN202180019399 A CN 202180019399A CN 115515579 B CN115515579 B CN 115515579B
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China
Prior art keywords
ethyl
mixture
stirred
give
carbamate
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CN202180019399.6A
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English (en)
Chinese (zh)
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CN115515579A (zh
Inventor
K·格内德瓦
A·J·哈德斯佩斯
N·卡斯坦
R·梁
P·T·美因克
D·J·哈金斯
N·J·利弗顿
L·A·百特
J·D·吉恩
R·W·迈尔斯
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Rockefeller University
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Rockefeller University
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/16—Otologicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
CN202180019399.6A 2020-02-05 2021-02-05 吡咯并[2,3-b]吡啶-3-甲酰胺组合物和改善听力损失的方法 Active CN115515579B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US202062970425P 2020-02-05 2020-02-05
US62/970,425 2020-02-05
PCT/US2021/016848 WO2021158936A1 (en) 2020-02-05 2021-02-05 Pyrrolo [2,3-b]pyridine-3-carboxamide compositions and methods for ameliorating hearing loss

Publications (2)

Publication Number Publication Date
CN115515579A CN115515579A (zh) 2022-12-23
CN115515579B true CN115515579B (zh) 2025-09-30

Family

ID=77199407

Family Applications (1)

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CN202180019399.6A Active CN115515579B (zh) 2020-02-05 2021-02-05 吡咯并[2,3-b]吡啶-3-甲酰胺组合物和改善听力损失的方法

Country Status (8)

Country Link
EP (1) EP4100008B1 (https=)
JP (1) JP7678595B2 (https=)
CN (1) CN115515579B (https=)
AU (1) AU2021215925B2 (https=)
CA (1) CA3170121A1 (https=)
ES (1) ES3025983T3 (https=)
MX (1) MX2022009572A (https=)
WO (1) WO2021158936A1 (https=)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2023015156A1 (en) * 2021-08-02 2023-02-09 Hudspeth A James Pyrrolopyridine-3- and 4-carboxamide compositions and methods for cellular proliferation
WO2024211621A1 (en) * 2023-04-04 2024-10-10 Children's Hospital Los Angeles Lats kinase inhibitor to treat retinal degeneration

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2888848B1 (fr) * 2005-07-22 2007-09-28 Sanofi Aventis Sa Derives de n-(arylalkyl)-1h-pyrrrolopyridine-2-carboxamides, leur preparation et leur application en therapeutique
WO2007067537A1 (en) * 2005-12-07 2007-06-14 Osi Pharmaceuticals, Inc. Pyrrolopyridine kinase inhibiting compounds
PE20121126A1 (es) * 2006-12-21 2012-08-24 Plexxikon Inc Compuestos pirrolo [2,3-b] piridinas como moduladores de quinasa
TWI667233B (zh) * 2013-12-19 2019-08-01 德商拜耳製藥公司 新穎吲唑羧醯胺，其製備方法、含彼等之醫藥製劑及其製造醫藥之用途
GB201602854D0 (en) * 2016-02-18 2016-04-06 Mission Therapeutics Ltd Novel compounds
JOP20190257A1 (ar) 2017-04-28 2019-10-28 Novartis Ag مركبات أريل غير متجانسة ثنائية الحلقة مندمجة 6-6 واستخدامها كمثبطات lats

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
Small-molecule inhibition of Lats kinases promotes Yap-dependent proliferation in postmitotic mammalian tissues;Nathaniel Kastan等;《bioRxiv》;20200416;1-42 *

Also Published As

Publication number Publication date
US20230137893A1 (en) 2023-05-04
WO2021158936A1 (en) 2021-08-12
AU2021215925A1 (en) 2022-09-08
EP4100008B1 (en) 2025-04-02
JP7678595B2 (ja) 2025-05-16
MX2022009572A (es) 2022-12-13
CA3170121A1 (en) 2021-08-12
EP4100008A4 (en) 2024-02-07
JP2023512823A (ja) 2023-03-29
AU2021215925B2 (en) 2026-04-09
EP4100008A1 (en) 2022-12-14
ES3025983T3 (en) 2025-06-10
CN115515579A (zh) 2022-12-23

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