AU2021215925B2 - Pyrrolo [2,3-b]pyridine-3-carboxamide compositions and methods for ameliorating hearing loss - Google Patents

Pyrrolo [2,3-b]pyridine-3-carboxamide compositions and methods for ameliorating hearing loss

Info

Publication number
AU2021215925B2
AU2021215925B2 AU2021215925A AU2021215925A AU2021215925B2 AU 2021215925 B2 AU2021215925 B2 AU 2021215925B2 AU 2021215925 A AU2021215925 A AU 2021215925A AU 2021215925 A AU2021215925 A AU 2021215925A AU 2021215925 B2 AU2021215925 B2 AU 2021215925B2
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AU
Australia
Prior art keywords
alkyl
mmol
ethyl
group
alkoxy
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
AU2021215925A
Other languages
English (en)
Other versions
AU2021215925A1 (en
Inventor
Leigh Ashley BAXT
John David Ginn
Ksenia GNEDEVA
A. James HUDSPETH
David John HUGGINS
Nathaniel KASTAN
Rui Liang
Nigel John LIVERTON
Peter T. Meinke
Robert Walter Myers
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Rockefeller University
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Rockefeller University
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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Publication date
Application filed by Rockefeller University filed Critical Rockefeller University
Publication of AU2021215925A1 publication Critical patent/AU2021215925A1/en
Application granted granted Critical
Publication of AU2021215925B2 publication Critical patent/AU2021215925B2/en
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/16—Otologicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
AU2021215925A 2020-02-05 2021-02-05 Pyrrolo [2,3-b]pyridine-3-carboxamide compositions and methods for ameliorating hearing loss Active AU2021215925B2 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US202062970425P 2020-02-05 2020-02-05
US62/970,425 2020-02-05
PCT/US2021/016848 WO2021158936A1 (en) 2020-02-05 2021-02-05 Pyrrolo [2,3-b]pyridine-3-carboxamide compositions and methods for ameliorating hearing loss

Publications (2)

Publication Number Publication Date
AU2021215925A1 AU2021215925A1 (en) 2022-09-08
AU2021215925B2 true AU2021215925B2 (en) 2026-04-09

Family

ID=77199407

Family Applications (1)

Application Number Title Priority Date Filing Date
AU2021215925A Active AU2021215925B2 (en) 2020-02-05 2021-02-05 Pyrrolo [2,3-b]pyridine-3-carboxamide compositions and methods for ameliorating hearing loss

Country Status (8)

Country Link
EP (1) EP4100008B1 (https=)
JP (1) JP7678595B2 (https=)
CN (1) CN115515579B (https=)
AU (1) AU2021215925B2 (https=)
CA (1) CA3170121A1 (https=)
ES (1) ES3025983T3 (https=)
MX (1) MX2022009572A (https=)
WO (1) WO2021158936A1 (https=)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2023015156A1 (en) * 2021-08-02 2023-02-09 Hudspeth A James Pyrrolopyridine-3- and 4-carboxamide compositions and methods for cellular proliferation
WO2024211621A1 (en) * 2023-04-04 2024-10-10 Children's Hospital Los Angeles Lats kinase inhibitor to treat retinal degeneration

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2018198077A2 (en) * 2017-04-28 2018-11-01 Novartis Ag 6-6 fused bicyclic heteroaryl compounds and their use as lats inhibitors

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2888848B1 (fr) * 2005-07-22 2007-09-28 Sanofi Aventis Sa Derives de n-(arylalkyl)-1h-pyrrrolopyridine-2-carboxamides, leur preparation et leur application en therapeutique
WO2007067537A1 (en) * 2005-12-07 2007-06-14 Osi Pharmaceuticals, Inc. Pyrrolopyridine kinase inhibiting compounds
PE20121126A1 (es) * 2006-12-21 2012-08-24 Plexxikon Inc Compuestos pirrolo [2,3-b] piridinas como moduladores de quinasa
TWI667233B (zh) * 2013-12-19 2019-08-01 德商拜耳製藥公司 新穎吲唑羧醯胺，其製備方法、含彼等之醫藥製劑及其製造醫藥之用途
GB201602854D0 (en) * 2016-02-18 2016-04-06 Mission Therapeutics Ltd Novel compounds

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2018198077A2 (en) * 2017-04-28 2018-11-01 Novartis Ag 6-6 fused bicyclic heteroaryl compounds and their use as lats inhibitors

Also Published As

Publication number Publication date
US20230137893A1 (en) 2023-05-04
WO2021158936A1 (en) 2021-08-12
AU2021215925A1 (en) 2022-09-08
EP4100008B1 (en) 2025-04-02
JP7678595B2 (ja) 2025-05-16
MX2022009572A (es) 2022-12-13
CA3170121A1 (en) 2021-08-12
EP4100008A4 (en) 2024-02-07
JP2023512823A (ja) 2023-03-29
EP4100008A1 (en) 2022-12-14
ES3025983T3 (en) 2025-06-10
CN115515579A (zh) 2022-12-23
CN115515579B (zh) 2025-09-30

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