CN115501135A - Anti-aging effect composition and application thereof - Google Patents
Anti-aging effect composition and application thereof Download PDFInfo
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- CN115501135A CN115501135A CN202211280639.0A CN202211280639A CN115501135A CN 115501135 A CN115501135 A CN 115501135A CN 202211280639 A CN202211280639 A CN 202211280639A CN 115501135 A CN115501135 A CN 115501135A
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/73—Polysaccharides
- A61K8/735—Mucopolysaccharides, e.g. hyaluronic acid; Derivatives thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/34—Alcohols
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/64—Proteins; Peptides; Derivatives or degradation products thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/08—Anti-ageing preparations
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
- A61K2800/59—Mixtures
- A61K2800/592—Mixtures of compounds complementing their respective functions
- A61K2800/5922—At least two compounds being classified in the same subclass of A61K8/18
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Abstract
The invention discloses an anti-aging effect composition, which comprises bakuchiol: 0.1-2 parts; polypeptide: 0.001-0.5 parts; hyaluronic acid and salts thereof: 0.05 to 3 parts by mass. The invention can play a role in resisting wrinkles from different skin layers and HAs a synergistic function, wherein the long-acting anti-wrinkle and tightening effects of the bakuchiol are utilized to stimulate the generation of collagen I and collagen III, the physiological functions of inhibiting inflammatory reaction, clearing free radicals and the like of the hyaluronic acid and the salts thereof are utilized to be combined with the moisturizing and film-forming effects of HA, the skin elasticity can be enhanced, the skin can be tightened, and the effects of resisting wrinkles, diminishing inflammation, tendering skin and preventing aging are achieved. Besides the effects of wrinkle and firming, the composition has outstanding appearance of increasing the thickness of the epidermis, and can repair the skin barrier and improve the roughness of the skin. The composition is easy to formulate, easy to store and safe to use, and is suitable for skin care products or cosmetics with anti-aging functions.
Description
Technical Field
The invention relates to the technical field of daily chemicals, in particular to an anti-aging effect composition and application thereof.
Background
Skin aging refers to the aging damage of skin function, which reduces the protection ability and regulation ability of skin to human body, so that the skin can not adapt to the change of internal and external environment, and the change of overall appearance conditions such as color, luster, shape, texture, etc. appears. Aging of the skin is classified into intrinsic aging and extrinsic aging. Endogenous aging refers to the natural aging of the skin as it ages; it is manifested as whitening of the skin, fine wrinkles, decreased elasticity, skin laxity, etc. The most prominent cause of extrinsic aging is photoaging due to sun exposure; skin discoloration manifested as wrinkles, loose skin, roughness, yellowish or grayish yellow, telangiectasia, formation of pigmented spots, and the like.
From the perspective of composition, there are three major categories of proven effective mainstream ingredients, which are: 1. a class A; 2. peptides and peptides; 3. Polysaccharides. The vitamin A is a large family, is one of the earliest proven anti-aging and wrinkle-removing components, and has been a standard pole for wrinkle removal in the cosmetic field for many years. The common commercially available vitamin A acid components comprise vitamin A acid, vitamin A aldehyde, vitamin A alcohol, vitamin A acetate, vitamin A propionate, retinol retinoic acid ester, vitamin A palmitate, and hydroxy pinacolone retinoic acid ester.
The vitamin A plays a role in really playing a role in resisting aging by combining retinoic acid (retinoic acid) with retinoic acid receptors to inhibit ATP-1 transcription factors and inhibit cell classification and generation of metalloproteases. The composition has the main effects of promoting the proliferation and differentiation of the keratinocytes of the epidermal basal layer, improving the thickness of epidermal cells and enhancing the barrier and thickness of skin; promoting fibroblast growth, stimulating the synthesis of I-type and III-type procollagens, promoting the generation of glycosaminoglycan, accelerating metabolism, and effectively preventing and reducing fine wrinkles; regulating desquamation of keratinized keratinocyte, inhibiting sebum synthesis of sebaceous gland, and preventing and treating acne; repairing light damage caused by UV, reducing metalloprotease level activated by ultraviolet irradiation, reducing collagen breakage and decomposition, reducing damage to collagen fiber, and reducing pigmentation.
Retinoids have various disadvantages such as strong efficacy and irritation of tretinoin, and unstable raw materials, which cannot be directly used, and the use of tretinoin in cosmetics is prohibited in all countries of the world. Research institutes around the world have developed retinol (retinal), retinol (retinol), retinol esters (derivatives of retinol), which release tretinoin into the skin to act.
The vitamin A palmitate is obtained by esterifying retinol and palmitic acid, is relatively stable, but has low activity and weak efficacy, needs to be converted in vivo, and has relatively strong irritation. In addition, because of its own biochemical properties, retinoids cause a lot of troubles in the addition of skin care products (cosmetics), which results in increased production cost and processing difficulty of skin care products (cosmetics); for example, retinoids are easy to irritate the skin, cause allergy or even teratogenesis, molting, flushing, dry skin, easily trigger photochemical reaction, generate peroxide for sensitization, and cause great care for consumers when using the skin care products (cosmetics); it is easy to hydrolyze, easy to oxidize, difficult to make in the formulation, cause the making condition to be harsh, make the cost high; and because of its light instability, the package is required to be protected from light, and the use needs to be extinguished at night, and the storage and the use are troublesome.
Psoralea corylifolia from Chinese pharmacopoeia: the product is dried mature fruit of Psoralea corylifolia L. The functional indications are as follows: warming kidney and tonifying yang, receiving qi, and stopping diarrhea; can be used for treating sexual impotence, spermatorrhea, frequent micturition, psychroalgia of waist and knee, asthma due to kidney deficiency, and diarrhea before dawn; it is used externally to treat vitiligo and alopecia areata. Bakuchiol is a phenolic substance extracted from the herbaceous plant Bakuchiol, so that it is named. It is not rare that the plants are available in many regions in south China and are easy to artificially plant.
The volcano charts of the bakuchiol and the retinol show that the gene spectrum expressions of the two compounds are very similar, which shows that the functions are similar, and the bakuchiol is easy to be formulated and has no photochemical reaction, so that the bakuchiol has good prospect when being applied to anti-aging skin care products (cosmetics).
According to the structure of the skin, aging can be divided into different levels of aging:
epidermal senescence: basal layer active cell reduction, slow metabolism, incomplete epidermal barrier, and reduced keratinocyte metabolism;
dermal connecting layer: the dermal papilla is flattened and the connection strength is weakened;
aging of dermis: loss of collagen and sodium hyaluronate, fibroblast dysfunction;
aging of subcutaneous tissues: fat displacement, gland secretion reduction due to gravity.
According to the liberation directions of different levels:
the solution direction of epidermal aging is as follows: activating subbase layer cells, repairing barriers and promoting stratum corneum metabolism;
dermal connecting layer: the effect of the bridge particles is enhanced, and the real surface connection is enhanced;
aging of dermis: supplementing hyaluronic acid, supplementing collagen production promoting signals such as polypeptides, promoting cell renewal by autophagy, filling hyaluronic acid, and extending telomerase;
aging of subcutaneous tissues: fat filling, raising estrogen level, promoting skin gland metabolism.
Many anti-aging cosmetics exist in the market, but the anti-aging cosmetics generally have the problems of insufficient efficacy, short duration of efficacy, instability, only night use and the like.
Disclosure of Invention
The invention aims to make up the defects, disclose an anti-aging composition which is easy to formulate, easy to store and safe to use to the society, and is suitable for skin care products or cosmetics with anti-aging functions.
The technical scheme of the invention is realized as follows:
an anti-aging composition comprises
Bakuchiol: 0.1 to 2 parts;
polypeptide: 0.001 to 0.5 portion;
hyaluronic acid and salts thereof: 0.05 to 3 portions;
the parts are parts by mass.
As a refinement, the polypeptide comprises a polypeptide having a neurotransmission blocker.
Further, the polypeptide comprises one or more of acetyl hexapeptide-8, melittin, snake venom peptide (dipeptide diaminobutyryl benzylamide diacetate), and conopeptide (arginine/lysine polypeptide).
As an improvement, the polypeptide comprises a polypeptide capable of promoting the production of collagen and elastin.
Further, the polypeptide comprises one or more of palmitoyl tripeptide-1, palmitoyl pentapeptide-4 and palmitoyl tripeptide-5.
As an improvement, the polypeptide comprises a metal ionophore polypeptide.
Further, the polypeptide comprises a blue copper peptide.
The polypeptide of the metal ion carrier can stimulate collagen synthesis, enhance immunity and improve anti-aging effect.
As an improvement, the hyaluronic acid and the salts thereof are one or more of sodium hyaluronate, hydrolyzed sodium hyaluronate, acetylated sodium hyaluronate and sodium hyaluronate cross-linked polymer.
The application of an anti-aging composition is used in skin care products or cosmetics.
Compared with the prior art, the invention has the advantages that:
the invention adopts the combination of bakuchiol, polypeptide, hyaluronic acid and salts thereof, can play a role in resisting wrinkles from different skin layers, and has a synergistic function, wherein the long-acting anti-wrinkle and tightening effects of the bakuchiol are utilized to stimulate the generation of collagen I and collagen III, the polypeptide with different effects is combined to play a role in instant wrinkle removal and long-acting wrinkle removal, and the instant wrinkle removal utilizes a nerve transmission retardant to relax muscles, so that the wrinkle removal effect can be achieved within 5 min. The hyaluronic acid and the salt thereof are utilized to inhibit inflammatory reaction, remove free radicals and other physiological functions, and are combined with the moisturizing and film-forming effects of HA, so that the skin elasticity can be enhanced, the skin can be tightened, and the effects of resisting wrinkles, diminishing inflammation, tendering skin and preventing aging can be achieved. Besides the effects of wrinkle and firming, the composition provided by the invention is very prominent in the increase of the thickness of the epidermis, and can repair the skin barrier and improve the roughness of the skin. The composition is easy to prepare, easy to store and safe to use, and is suitable for skin care products or cosmetics with anti-aging functions.
Drawings
FIG. 1 is a comparison graph I of experimental results of the present invention;
FIG. 2 is a graph II comparing the experimental results of the present invention;
FIG. 3 is a comparison of the results of the experiments of the present invention;
FIG. 4 is a graph IV comparing the results of the experiments of the present invention;
FIG. 5 is a graph comparing the results of the experiment of the present invention.
Detailed Description
In order to make the present invention more comprehensible, the technical solutions of the present invention are further described below with reference to specific embodiments, but the present invention is not limited thereto.
The invention is described in further detail below:
an anti-aging composition comprises
Bakuchiol: 0.1 to 2 parts;
polypeptide: 0.001 to 0.5 portion;
hyaluronic acid and salts thereof: 0.05 to 3 portions; the parts are parts by mass.
Wherein the bakuchiol can exert long-acting anti-wrinkle and firming effects, and stimulate the generation of collagen I and collagen III to regulate the combination of retinol and metabolic genes; the bakuchiol is extracted from plants, or can be artificially synthesized.
The hyaluronic acid and the salt thereof are one or more of sodium hyaluronate, hydrolyzed sodium hyaluronate, acetylated sodium hyaluronate and sodium hyaluronate cross-linked polymer.
Sodium hyaluronate: has a chemical formula of (C) 14 H 20 NO 11 Na) n is an inherent component in human body, is a glucan aldehyde acid, has no species specificity, and is widely present in tissues and organs such as placenta, amniotic fluid, crystalline lens, articular cartilage, skin dermis and the like. Sodium hyaluronate is distributed in cytoplasm and intercellular substance, and can be used for treating cell contained thereinAnd the cell organs themselves play a lubricating and nourishing role. The traditional theory holds that the formation of wrinkles is related to the breakage or loss of collagen elastic fibers; modern medical research has found that another root cause of wrinkle formation is the alteration of the intercellular matrix, i.e. the reduction of the amorphous component "hyaluronic acid" between cells, while the cytoskeleton and elastic fibers are still present. Micro-face-lifting is to supplement lost intangible interstitial components to further change the metabolic environment of cells and the balance of water and ions, thereby increasing the viscoelasticity of the skin and achieving the face-lifting effect. In the composition, physiological functions of hyaluronic acid and salts thereof such as inhibiting inflammatory reaction and scavenging free radicals are utilized, and the composition is combined with the moisturizing and film-forming effects of HA, so that the composition can enhance the skin elasticity, tighten the skin and achieve the effects of resisting wrinkles, diminishing inflammation, tendering the skin and preventing aging.
In addition, the composition comprises polypeptides which mainly comprise the following three types:
the polypeptide with nerve transmission blocker comprises one or more of acetyl hexapeptide-8, melittin, snake venom peptide (dipeptide diaminobutyryl benzylamide diacetate), and conopeptide (arginine/lysine polypeptide).
The polypeptide capable of promoting collagen and elastin production comprises one or more of palmitoyl tripeptide-1, palmitoyl pentapeptide-4 and palmitoyl tripeptide-5.
Metal ionophore polypeptides, such as copper cyanamide.
The polypeptide of the metal ion carrier can stimulate collagen synthesis, enhance immunity and improve anti-aging effect.
The composition disclosed by the invention contains the combination of the bakuchiol, the polypeptide, the hyaluronic acid and the salts thereof, can play a role in resisting wrinkles from different skin layers, has a synergistic function, has remarkable effects on increasing the thickness of epidermis besides the effects of wrinkles and tightening, and can repair skin barriers and improve the roughness of the skin. The composition has the anti-aging effect, is easy to formulate, easy to store and safe to use, and is suitable for skin care products or cosmetics.
The following is a list of ingredients for 5 skin care or cosmetic examples containing the anti-aging effect composition and 1 comparative example.
Example 1:
example 2:
example 3:
example 4:
example 5:
comparative example a:
comparative example B:
the use effect comparison of example 5 with comparative examples a and B was performed (10 persons for each subject):
inclusion criteria for subjects:
healthy women, age: 25-45 years old;
asians (china);
the facial skin is dull, dark, rough and lack of elasticity;
randomly grading the visual score of fine lines under the eyes of one side to be 2-6 grades;
forehead fine line visual score grade 2-6;
the facial skin has no obvious skin damage, scars, hairs and the like;
the test can be well matched according to the requirements of the test scheme, and the life regularity can be maintained during the test.
Testing an instrument: skin V is suitable for beautifying.
Example 5, comparative example a, comparative example B were prepared as essence creams for testing, and facial skin test was performed as baselin using american skin V before use [ day 0 ].
The samples were treated blindly.
Instant wrinkle removing effect: after 5min after application, the skin condition was tested using skin care test chart V and the data was analyzed.
And (3) analysis of test results: as shown in fig. 1-3 (left panel before use, right panel after use), the subject applied right facial smear example 5, left facial smear comparative example B; from the test results, it can be seen that there is a reduction in the fine lines under both eyes, and the right side (application example 5) improves the fine lines under the eyes better than the left side (application comparative example B).
As shown in fig. 4 (left panel before use, right panel after use), subject right facial smear example 5, left facial smear comparative example a; as can be seen from the test results, the wrinkles on the right are reduced obviously, and the wrinkles on the left are not reduced and increased, which indicates that the immediate wrinkle removing effect of the right face (smearing example 5) is significantly better than that of the left face (smearing comparative example a).
Long-term anti-wrinkle effect: 3 groups are set, namely, a group of example 5, a group of comparative example A and a group of comparative example B, 5 persons in each group are tried for 7 days continuously, and the skin beautifying detection time point: baselin [ day 0 ], 7d. And performing data analysis according to the skin detection result.
The service cycle is as follows: face detection and analysis were performed on day 28, day 1, and day 7, respectively.
After 7 days of continuous morning and evening usage, example 5 is superior to comparative examples A and B in pore area, wrinkle volume-under-the-eye fine lines, wrinkle volume-lines of law, skin keratinous moisture, etc. As shown in FIG. 5, the effect before use is compared with that after 5,7 days of the use example.
The composition has superiority in anti-wrinkle, has instant wrinkle removing effect, and has long-acting anti-wrinkle effect. The long-acting anti-wrinkle effect is specifically solved according to skin aging of different layers, and a better anti-wrinkle effect is achieved.
It will be appreciated by persons skilled in the art that the embodiments of the invention described above and shown in the drawings are given by way of example only and are not limiting of the invention. The objects of the present invention have been fully and effectively accomplished. Any variations or modifications may be made to the embodiments of the invention without departing from the principles described.
Claims (9)
1. An anti-aging effect composition is characterized in that: comprises that
Bakuchiol: 0.1-2 parts;
polypeptide: 0.001 to 0.5 parts;
hyaluronic acid and salts thereof: 0.05 to 3 parts;
the parts are parts by mass.
2. The anti-aging composition as claimed in claim 1, wherein: the polypeptide comprises a polypeptide with a neurotransmission blocker.
3. The anti-aging composition as claimed in claim 2, wherein: the polypeptide comprises one or more of acetyl hexapeptide-8, melittin, snake venom peptide and conopeptide.
4. The anti-aging composition as claimed in claim 1, wherein: the polypeptide comprises a polypeptide capable of promoting collagen and elastin production.
5. The anti-aging composition according to claim 4, wherein: the polypeptide comprises one or more of palmitoyl tripeptide-1, palmitoyl pentapeptide-4 and palmitoyl tripeptide-5.
6. The anti-aging composition as claimed in claim 1, wherein: the polypeptide comprises a polypeptide of a metal ion carrier.
7. The anti-aging composition according to claim 6, wherein: the polypeptide comprises a copper-blue peptide.
8. The anti-aging composition as claimed in claim 1, wherein: the hyaluronic acid and the salts thereof are one or more of sodium hyaluronate, hydrolyzed sodium hyaluronate, acetylated sodium hyaluronate and sodium hyaluronate cross-linked polymer.
9. Use of an anti-ageing composition according to any one of claims 1 to 8, wherein: the anti-aging effect composition is used in skin care products or cosmetics.
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| CN116115540A (en) * | 2023-03-20 | 2023-05-16 | 广东雅丽洁精细化工有限公司 | Skin anti-aging composition, application and daily chemical product |
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