CN115463185A - Massage oil for relieving pain and preparation method thereof - Google Patents
Massage oil for relieving pain and preparation method thereof Download PDFInfo
- Publication number
- CN115463185A CN115463185A CN202111437448.6A CN202111437448A CN115463185A CN 115463185 A CN115463185 A CN 115463185A CN 202111437448 A CN202111437448 A CN 202111437448A CN 115463185 A CN115463185 A CN 115463185A
- Authority
- CN
- China
- Prior art keywords
- parts
- oil
- essential oil
- traditional chinese
- chinese medicine
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 208000002193 Pain Diseases 0.000 title claims abstract description 85
- 238000002360 preparation method Methods 0.000 title claims abstract description 33
- 239000000341 volatile oil Substances 0.000 claims abstract description 131
- 239000000203 mixture Substances 0.000 claims abstract description 117
- 239000000284 extract Substances 0.000 claims abstract description 116
- 239000003814 drug Substances 0.000 claims abstract description 92
- 239000003921 oil Substances 0.000 claims abstract description 80
- 239000000654 additive Substances 0.000 claims abstract description 53
- 230000000996 additive effect Effects 0.000 claims abstract description 53
- 239000003906 humectant Substances 0.000 claims abstract description 50
- 239000002904 solvent Substances 0.000 claims abstract description 46
- 238000010438 heat treatment Methods 0.000 claims abstract description 37
- 238000003756 stirring Methods 0.000 claims abstract description 34
- 239000002994 raw material Substances 0.000 claims abstract description 28
- 238000010992 reflux Methods 0.000 claims abstract description 24
- 238000002156 mixing Methods 0.000 claims abstract description 15
- 235000019198 oils Nutrition 0.000 claims description 77
- 238000006243 chemical reaction Methods 0.000 claims description 44
- 150000001875 compounds Chemical class 0.000 claims description 38
- 108090000623 proteins and genes Proteins 0.000 claims description 37
- 102000004169 proteins and genes Human genes 0.000 claims description 37
- 235000021307 Triticum Nutrition 0.000 claims description 36
- 239000010466 nut oil Substances 0.000 claims description 29
- 229940092665 tea leaf extract Drugs 0.000 claims description 29
- 235000004347 Perilla Nutrition 0.000 claims description 24
- 244000124853 Perilla frutescens Species 0.000 claims description 24
- 239000010480 babassu oil Substances 0.000 claims description 24
- 239000004475 Arginine Substances 0.000 claims description 23
- PMMYEEVYMWASQN-DMTCNVIQSA-N Hydroxyproline Chemical compound O[C@H]1CN[C@H](C(O)=O)C1 PMMYEEVYMWASQN-DMTCNVIQSA-N 0.000 claims description 23
- ODKSFYDXXFIFQN-BYPYZUCNSA-P L-argininium(2+) Chemical compound NC(=[NH2+])NCCC[C@H]([NH3+])C(O)=O ODKSFYDXXFIFQN-BYPYZUCNSA-P 0.000 claims description 23
- 235000018330 Macadamia integrifolia Nutrition 0.000 claims description 23
- 235000003800 Macadamia tetraphylla Nutrition 0.000 claims description 23
- 240000000912 Macadamia tetraphylla Species 0.000 claims description 23
- 229960003121 arginine Drugs 0.000 claims description 23
- ODKSFYDXXFIFQN-UHFFFAOYSA-N arginine Natural products OC(=O)C(N)CCCNC(N)=N ODKSFYDXXFIFQN-UHFFFAOYSA-N 0.000 claims description 23
- PMMYEEVYMWASQN-UHFFFAOYSA-N dl-hydroxyproline Natural products OC1C[NH2+]C(C([O-])=O)C1 PMMYEEVYMWASQN-UHFFFAOYSA-N 0.000 claims description 23
- 229960002591 hydroxyproline Drugs 0.000 claims description 23
- FGMPLJWBKKVCDB-UHFFFAOYSA-N trans-L-hydroxy-proline Natural products ON1CCCC1C(O)=O FGMPLJWBKKVCDB-UHFFFAOYSA-N 0.000 claims description 23
- 235000008227 Illicium verum Nutrition 0.000 claims description 21
- 240000007232 Illicium verum Species 0.000 claims description 21
- 241000304195 Salvia miltiorrhiza Species 0.000 claims description 15
- 235000009051 Ambrosia paniculata var. peruviana Nutrition 0.000 claims description 14
- 235000003097 Artemisia absinthium Nutrition 0.000 claims description 14
- 240000001851 Artemisia dracunculus Species 0.000 claims description 14
- 235000017731 Artemisia dracunculus ssp. dracunculus Nutrition 0.000 claims description 14
- 235000003261 Artemisia vulgaris Nutrition 0.000 claims description 14
- 241000112528 Ligusticum striatum Species 0.000 claims description 14
- 244000131316 Panax pseudoginseng Species 0.000 claims description 14
- 235000003181 Panax pseudoginseng Nutrition 0.000 claims description 14
- 235000011135 Salvia miltiorrhiza Nutrition 0.000 claims description 14
- 239000001138 artemisia absinthium Substances 0.000 claims description 14
- KDYFGRWQOYBRFD-UHFFFAOYSA-N succinic acid Chemical compound OC(=O)CCC(O)=O KDYFGRWQOYBRFD-UHFFFAOYSA-N 0.000 claims description 14
- 244000018716 Impatiens biflora Species 0.000 claims description 13
- 235000015912 Impatiens biflora Nutrition 0.000 claims description 13
- 235000005155 Tanacetum balsamita Nutrition 0.000 claims description 13
- 238000001035 drying Methods 0.000 claims description 13
- 238000005303 weighing Methods 0.000 claims description 12
- 238000001816 cooling Methods 0.000 claims description 11
- 238000001914 filtration Methods 0.000 claims description 11
- 230000001954 sterilising effect Effects 0.000 claims description 11
- 238000004659 sterilization and disinfection Methods 0.000 claims description 8
- 230000003020 moisturizing effect Effects 0.000 claims description 5
- 244000144725 Amygdalus communis Species 0.000 claims description 4
- 235000011437 Amygdalus communis Nutrition 0.000 claims description 4
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 claims description 4
- DHMQDGOQFOQNFH-UHFFFAOYSA-N Glycine Chemical compound NCC(O)=O DHMQDGOQFOQNFH-UHFFFAOYSA-N 0.000 claims description 4
- DATAGRPVKZEWHA-YFKPBYRVSA-N N(5)-ethyl-L-glutamine Chemical compound CCNC(=O)CC[C@H]([NH3+])C([O-])=O DATAGRPVKZEWHA-YFKPBYRVSA-N 0.000 claims description 4
- 239000003795 chemical substances by application Substances 0.000 claims description 4
- 240000003538 Chamaemelum nobile Species 0.000 claims description 2
- 235000007866 Chamaemelum nobile Nutrition 0.000 claims description 2
- 241000195493 Cryptophyta Species 0.000 claims description 2
- 241000555682 Forsythia x intermedia Species 0.000 claims description 2
- 239000006000 Garlic extract Substances 0.000 claims description 2
- 239000004471 Glycine Substances 0.000 claims description 2
- 244000308760 Helichrysum petiolatum Species 0.000 claims description 2
- 229920000057 Mannan Polymers 0.000 claims description 2
- 235000007232 Matricaria chamomilla Nutrition 0.000 claims description 2
- 244000179970 Monarda didyma Species 0.000 claims description 2
- 235000010672 Monarda didyma Nutrition 0.000 claims description 2
- 235000011203 Origanum Nutrition 0.000 claims description 2
- 240000000783 Origanum majorana Species 0.000 claims description 2
- 235000008184 Piper nigrum Nutrition 0.000 claims description 2
- 244000203593 Piper nigrum Species 0.000 claims description 2
- 240000000513 Santalum album Species 0.000 claims description 2
- 235000008632 Santalum album Nutrition 0.000 claims description 2
- 235000016639 Syzygium aromaticum Nutrition 0.000 claims description 2
- 244000223014 Syzygium aromaticum Species 0.000 claims description 2
- 235000020224 almond Nutrition 0.000 claims description 2
- 239000008168 almond oil Substances 0.000 claims description 2
- 235000021302 avocado oil Nutrition 0.000 claims description 2
- 239000008163 avocado oil Substances 0.000 claims description 2
- 235000013614 black pepper Nutrition 0.000 claims description 2
- 235000020706 garlic extract Nutrition 0.000 claims description 2
- 229940107131 ginseng root Drugs 0.000 claims description 2
- 235000011187 glycerol Nutrition 0.000 claims description 2
- 239000008169 grapeseed oil Substances 0.000 claims description 2
- 235000010987 pectin Nutrition 0.000 claims description 2
- 229920001277 pectin Polymers 0.000 claims description 2
- 239000001814 pectin Substances 0.000 claims description 2
- 239000010664 perilla essential oil Substances 0.000 claims description 2
- -1 phytosterol Substances 0.000 claims description 2
- 229940026510 theanine Drugs 0.000 claims description 2
- 244000098338 Triticum aestivum Species 0.000 claims 2
- 241001672694 Citrus reticulata Species 0.000 claims 1
- 244000246386 Mentha pulegium Species 0.000 claims 1
- 235000016257 Mentha pulegium Nutrition 0.000 claims 1
- 235000004357 Mentha x piperita Nutrition 0.000 claims 1
- 239000004909 Moisturizer Substances 0.000 claims 1
- 229940024606 amino acid Drugs 0.000 claims 1
- 150000001413 amino acids Chemical class 0.000 claims 1
- 241000411851 herbal medicine Species 0.000 claims 1
- 235000001050 hortel pimenta Nutrition 0.000 claims 1
- 238000000034 method Methods 0.000 claims 1
- 230000001333 moisturizer Effects 0.000 claims 1
- 230000014759 maintenance of location Effects 0.000 abstract description 8
- 230000007721 medicinal effect Effects 0.000 abstract description 8
- 241000894006 Bacteria Species 0.000 abstract description 4
- 229940126680 traditional chinese medicines Drugs 0.000 abstract description 2
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 47
- 241000209140 Triticum Species 0.000 description 34
- 239000011259 mixed solution Substances 0.000 description 20
- 239000000243 solution Substances 0.000 description 16
- 239000000126 substance Substances 0.000 description 16
- 210000003491 skin Anatomy 0.000 description 15
- 230000000052 comparative effect Effects 0.000 description 14
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 13
- 230000000694 effects Effects 0.000 description 11
- 230000003647 oxidation Effects 0.000 description 11
- 238000007254 oxidation reaction Methods 0.000 description 11
- 241001122767 Theaceae Species 0.000 description 9
- 238000005516 engineering process Methods 0.000 description 6
- 239000000463 material Substances 0.000 description 6
- 235000019488 nut oil Nutrition 0.000 description 6
- 230000008961 swelling Effects 0.000 description 6
- 240000007436 Cananga odorata Species 0.000 description 4
- 102000008186 Collagen Human genes 0.000 description 4
- 108010035532 Collagen Proteins 0.000 description 4
- 229920001436 collagen Polymers 0.000 description 4
- 230000002195 synergetic effect Effects 0.000 description 4
- 206010049816 Muscle tightness Diseases 0.000 description 3
- 230000017531 blood circulation Effects 0.000 description 3
- 230000001737 promoting effect Effects 0.000 description 3
- 208000024891 symptom Diseases 0.000 description 3
- GVJHHUAWPYXKBD-UHFFFAOYSA-N (±)-α-Tocopherol Chemical compound OC1=C(C)C(C)=C2OC(CCCC(C)CCCC(C)CCCC(C)C)(C)CCC2=C1C GVJHHUAWPYXKBD-UHFFFAOYSA-N 0.000 description 2
- 241000208340 Araliaceae Species 0.000 description 2
- 208000006820 Arthralgia Diseases 0.000 description 2
- 240000009023 Myrrhis odorata Species 0.000 description 2
- 235000007265 Myrrhis odorata Nutrition 0.000 description 2
- 235000012550 Pimpinella anisum Nutrition 0.000 description 2
- 206010038743 Restlessness Diseases 0.000 description 2
- XCPQUQHBVVXMRQ-UHFFFAOYSA-N alpha-Fenchene Natural products C1CC2C(=C)CC1C2(C)C XCPQUQHBVVXMRQ-UHFFFAOYSA-N 0.000 description 2
- SESFRYSPDFLNCH-UHFFFAOYSA-N benzyl benzoate Chemical compound C=1C=CC=CC=1C(=O)OCC1=CC=CC=C1 SESFRYSPDFLNCH-UHFFFAOYSA-N 0.000 description 2
- 239000008280 blood Substances 0.000 description 2
- 210000004369 blood Anatomy 0.000 description 2
- 238000009395 breeding Methods 0.000 description 2
- 230000001488 breeding effect Effects 0.000 description 2
- CRPUJAZIXJMDBK-UHFFFAOYSA-N camphene Chemical compound C1CC2C(=C)C(C)(C)C1C2 CRPUJAZIXJMDBK-UHFFFAOYSA-N 0.000 description 2
- 230000006866 deterioration Effects 0.000 description 2
- POULHZVOKOAJMA-UHFFFAOYSA-N dodecanoic acid Chemical compound CCCCCCCCCCCC(O)=O POULHZVOKOAJMA-UHFFFAOYSA-N 0.000 description 2
- 230000001976 improved effect Effects 0.000 description 2
- CDOSHBSSFJOMGT-UHFFFAOYSA-N linalool Chemical compound CC(C)=CCCC(C)(O)C=C CDOSHBSSFJOMGT-UHFFFAOYSA-N 0.000 description 2
- 235000010446 mineral oil Nutrition 0.000 description 2
- 239000002480 mineral oil Substances 0.000 description 2
- ZRSNZINYAWTAHE-UHFFFAOYSA-N p-methoxybenzaldehyde Chemical compound COC1=CC=C(C=O)C=C1 ZRSNZINYAWTAHE-UHFFFAOYSA-N 0.000 description 2
- RUMOYJJNUMEFDD-UHFFFAOYSA-N perillyl aldehyde Chemical compound CC(=C)C1CCC(C=O)=CC1 RUMOYJJNUMEFDD-UHFFFAOYSA-N 0.000 description 2
- 230000002040 relaxant effect Effects 0.000 description 2
- 230000000472 traumatic effect Effects 0.000 description 2
- GRWFGVWFFZKLTI-UHFFFAOYSA-N α-pinene Chemical compound CC1=CCC2C(C)(C)C1C2 GRWFGVWFFZKLTI-UHFFFAOYSA-N 0.000 description 2
- NPNUFJAVOOONJE-ZIAGYGMSSA-N β-(E)-Caryophyllene Chemical compound C1CC(C)=CCCC(=C)[C@H]2CC(C)(C)[C@@H]21 NPNUFJAVOOONJE-ZIAGYGMSSA-N 0.000 description 2
- WTARULDDTDQWMU-RKDXNWHRSA-N (+)-β-pinene Chemical compound C1[C@H]2C(C)(C)[C@@H]1CCC2=C WTARULDDTDQWMU-RKDXNWHRSA-N 0.000 description 1
- WMBWREPUVVBILR-WIYYLYMNSA-N (-)-Epigallocatechin-3-o-gallate Chemical compound O([C@@H]1CC2=C(O)C=C(C=C2O[C@@H]1C=1C=C(O)C(O)=C(O)C=1)O)C(=O)C1=CC(O)=C(O)C(O)=C1 WMBWREPUVVBILR-WIYYLYMNSA-N 0.000 description 1
- WTARULDDTDQWMU-IUCAKERBSA-N (-)-Nopinene Natural products C1[C@@H]2C(C)(C)[C@H]1CCC2=C WTARULDDTDQWMU-IUCAKERBSA-N 0.000 description 1
- 239000001490 (3R)-3,7-dimethylocta-1,6-dien-3-ol Substances 0.000 description 1
- CDOSHBSSFJOMGT-JTQLQIEISA-N (R)-linalool Natural products CC(C)=CCC[C@@](C)(O)C=C CDOSHBSSFJOMGT-JTQLQIEISA-N 0.000 description 1
- GRWFGVWFFZKLTI-IUCAKERBSA-N 1S,5S-(-)-alpha-Pinene Natural products CC1=CC[C@@H]2C(C)(C)[C@H]1C2 GRWFGVWFFZKLTI-IUCAKERBSA-N 0.000 description 1
- HIQIXEFWDLTDED-UHFFFAOYSA-N 4-hydroxy-1-piperidin-4-ylpyrrolidin-2-one Chemical compound O=C1CC(O)CN1C1CCNCC1 HIQIXEFWDLTDED-UHFFFAOYSA-N 0.000 description 1
- 208000004998 Abdominal Pain Diseases 0.000 description 1
- 235000013073 Acorus gramineus Nutrition 0.000 description 1
- 244000001632 Acorus gramineus Species 0.000 description 1
- 201000000736 Amenorrhea Diseases 0.000 description 1
- 206010001928 Amenorrhoea Diseases 0.000 description 1
- 241000208173 Apiaceae Species 0.000 description 1
- 241001435059 Artemisia argyi Species 0.000 description 1
- 235000010894 Artemisia argyi Nutrition 0.000 description 1
- 241000092668 Artemisia capillaris Species 0.000 description 1
- 235000008658 Artemisia capillaris Nutrition 0.000 description 1
- 241000208838 Asteraceae Species 0.000 description 1
- 241000255789 Bombyx mori Species 0.000 description 1
- XMWRBQBLMFGWIX-UHFFFAOYSA-N C60 fullerene Chemical compound C12=C3C(C4=C56)=C7C8=C5C5=C9C%10=C6C6=C4C1=C1C4=C6C6=C%10C%10=C9C9=C%11C5=C8C5=C8C7=C3C3=C7C2=C1C1=C2C4=C6C4=C%10C6=C9C9=C%11C5=C5C8=C3C3=C7C1=C1C2=C4C6=C2C9=C5C3=C12 XMWRBQBLMFGWIX-UHFFFAOYSA-N 0.000 description 1
- 235000007571 Cananga odorata Nutrition 0.000 description 1
- WTEVQBCEXWBHNA-UHFFFAOYSA-N Citral Natural products CC(C)=CCCC(C)=CC=O WTEVQBCEXWBHNA-UHFFFAOYSA-N 0.000 description 1
- 235000015655 Crocus sativus Nutrition 0.000 description 1
- 244000124209 Crocus sativus Species 0.000 description 1
- LEVWYRKDKASIDU-QWWZWVQMSA-N D-cystine Chemical compound OC(=O)[C@H](N)CSSC[C@@H](N)C(O)=O LEVWYRKDKASIDU-QWWZWVQMSA-N 0.000 description 1
- 208000005171 Dysmenorrhea Diseases 0.000 description 1
- 206010013935 Dysmenorrhoea Diseases 0.000 description 1
- 241000196324 Embryophyta Species 0.000 description 1
- 241000208421 Ericaceae Species 0.000 description 1
- 235000014066 European mistletoe Nutrition 0.000 description 1
- 241000220485 Fabaceae Species 0.000 description 1
- WMBWREPUVVBILR-UHFFFAOYSA-N GCG Natural products C=1C(O)=C(O)C(O)=CC=1C1OC2=CC(O)=CC(O)=C2CC1OC(=O)C1=CC(O)=C(O)C(O)=C1 WMBWREPUVVBILR-UHFFFAOYSA-N 0.000 description 1
- 241000287828 Gallus gallus Species 0.000 description 1
- 241000735588 Gaultheria Species 0.000 description 1
- 235000006200 Glycyrrhiza glabra Nutrition 0.000 description 1
- 244000303040 Glycyrrhiza glabra Species 0.000 description 1
- 206010019233 Headaches Diseases 0.000 description 1
- 208000032843 Hemorrhage Diseases 0.000 description 1
- 206010062717 Increased upper airway secretion Diseases 0.000 description 1
- 241000207923 Lamiaceae Species 0.000 description 1
- 239000005639 Lauric acid Substances 0.000 description 1
- 241000244365 Ligusticum sinense Species 0.000 description 1
- 241001481296 Malus spectabilis Species 0.000 description 1
- 208000037093 Menstruation Disturbances Diseases 0.000 description 1
- 206010027339 Menstruation irregular Diseases 0.000 description 1
- 235000006679 Mentha X verticillata Nutrition 0.000 description 1
- 235000002899 Mentha suaveolens Nutrition 0.000 description 1
- 235000001636 Mentha x rotundifolia Nutrition 0.000 description 1
- 241000180649 Panax notoginseng Species 0.000 description 1
- 235000003143 Panax notoginseng Nutrition 0.000 description 1
- 241000222640 Polyporus Species 0.000 description 1
- PXRCIOIWVGAZEP-UHFFFAOYSA-N Primaeres Camphenhydrat Natural products C1CC2C(O)(C)C(C)(C)C1C2 PXRCIOIWVGAZEP-UHFFFAOYSA-N 0.000 description 1
- 102000004079 Prolyl Hydroxylases Human genes 0.000 description 1
- 108010043005 Prolyl Hydroxylases Proteins 0.000 description 1
- 208000003251 Pruritus Diseases 0.000 description 1
- WTARULDDTDQWMU-UHFFFAOYSA-N Pseudopinene Natural products C1C2C(C)(C)C1CCC2=C WTARULDDTDQWMU-UHFFFAOYSA-N 0.000 description 1
- 208000001431 Psychomotor Agitation Diseases 0.000 description 1
- 208000025747 Rheumatic disease Diseases 0.000 description 1
- 244000152640 Rhipsalis cassutha Species 0.000 description 1
- 235000012300 Rhipsalis cassutha Nutrition 0.000 description 1
- 240000000528 Ricinus communis Species 0.000 description 1
- 235000004443 Ricinus communis Nutrition 0.000 description 1
- 241000612118 Samolus valerandi Species 0.000 description 1
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 description 1
- 208000013738 Sleep Initiation and Maintenance disease Diseases 0.000 description 1
- 208000005392 Spasm Diseases 0.000 description 1
- 235000021355 Stearic acid Nutrition 0.000 description 1
- 206010053476 Traumatic haemorrhage Diseases 0.000 description 1
- 235000007212 Verbena X moechina Moldenke Nutrition 0.000 description 1
- 240000001519 Verbena officinalis Species 0.000 description 1
- 235000001594 Verbena polystachya Kunth Nutrition 0.000 description 1
- 235000007200 Verbena x perriana Moldenke Nutrition 0.000 description 1
- 235000002270 Verbena x stuprosa Moldenke Nutrition 0.000 description 1
- 241000219873 Vicia Species 0.000 description 1
- 241001659769 Vicia amoena Species 0.000 description 1
- 241000700605 Viruses Species 0.000 description 1
- 229930003427 Vitamin E Natural products 0.000 description 1
- 208000027418 Wounds and injury Diseases 0.000 description 1
- 230000003187 abdominal effect Effects 0.000 description 1
- 238000010521 absorption reaction Methods 0.000 description 1
- 238000009825 accumulation Methods 0.000 description 1
- 230000003213 activating effect Effects 0.000 description 1
- 238000001467 acupuncture Methods 0.000 description 1
- 150000001298 alcohols Chemical class 0.000 description 1
- 229930013930 alkaloid Natural products 0.000 description 1
- 150000003797 alkaloid derivatives Chemical class 0.000 description 1
- MVNCAPSFBDBCGF-UHFFFAOYSA-N alpha-pinene Natural products CC1=CCC23C1CC2C3(C)C MVNCAPSFBDBCGF-UHFFFAOYSA-N 0.000 description 1
- 231100000540 amenorrhea Toxicity 0.000 description 1
- 230000000844 anti-bacterial effect Effects 0.000 description 1
- 230000003110 anti-inflammatory effect Effects 0.000 description 1
- 230000001390 anti-relaxing effect Effects 0.000 description 1
- 239000003963 antioxidant agent Substances 0.000 description 1
- 235000006708 antioxidants Nutrition 0.000 description 1
- 230000036528 appetite Effects 0.000 description 1
- 235000019789 appetite Nutrition 0.000 description 1
- 125000000637 arginyl group Chemical group N[C@@H](CCCNC(N)=N)C(=O)* 0.000 description 1
- 230000001580 bacterial effect Effects 0.000 description 1
- 230000004888 barrier function Effects 0.000 description 1
- 239000002199 base oil Substances 0.000 description 1
- 239000011324 bead Substances 0.000 description 1
- 229960002903 benzyl benzoate Drugs 0.000 description 1
- NPNUFJAVOOONJE-UHFFFAOYSA-N beta-cariophyllene Natural products C1CC(C)=CCCC(=C)C2CC(C)(C)C21 NPNUFJAVOOONJE-UHFFFAOYSA-N 0.000 description 1
- 229930006722 beta-pinene Natural products 0.000 description 1
- 230000004071 biological effect Effects 0.000 description 1
- 230000015572 biosynthetic process Effects 0.000 description 1
- 230000000740 bleeding effect Effects 0.000 description 1
- 210000004204 blood vessel Anatomy 0.000 description 1
- 210000000988 bone and bone Anatomy 0.000 description 1
- 229930006739 camphene Natural products 0.000 description 1
- ZYPYEBYNXWUCEA-UHFFFAOYSA-N camphenilone Natural products C1CC2C(=O)C(C)(C)C1C2 ZYPYEBYNXWUCEA-UHFFFAOYSA-N 0.000 description 1
- NPNUFJAVOOONJE-UONOGXRCSA-N caryophyllene Natural products C1CC(C)=CCCC(=C)[C@@H]2CC(C)(C)[C@@H]21 NPNUFJAVOOONJE-UONOGXRCSA-N 0.000 description 1
- 230000009920 chelation Effects 0.000 description 1
- 230000004087 circulation Effects 0.000 description 1
- 229940043350 citral Drugs 0.000 description 1
- 235000009508 confectionery Nutrition 0.000 description 1
- 238000004132 cross linking Methods 0.000 description 1
- 229960003067 cystine Drugs 0.000 description 1
- 230000006378 damage Effects 0.000 description 1
- 239000008367 deionised water Substances 0.000 description 1
- 229910021641 deionized water Inorganic materials 0.000 description 1
- 210000004207 dermis Anatomy 0.000 description 1
- 230000003467 diminishing effect Effects 0.000 description 1
- 210000004177 elastic tissue Anatomy 0.000 description 1
- 229940030275 epigallocatechin gallate Drugs 0.000 description 1
- 210000002919 epithelial cell Anatomy 0.000 description 1
- 239000000835 fiber Substances 0.000 description 1
- 210000002950 fibroblast Anatomy 0.000 description 1
- 229910003472 fullerene Inorganic materials 0.000 description 1
- LCWMKIHBLJLORW-UHFFFAOYSA-N gamma-carene Natural products C1CC(=C)CC2C(C)(C)C21 LCWMKIHBLJLORW-UHFFFAOYSA-N 0.000 description 1
- WIGCFUFOHFEKBI-UHFFFAOYSA-N gamma-tocopherol Natural products CC(C)CCCC(C)CCCC(C)CCCC1CCC2C(C)C(O)C(C)C(C)C2O1 WIGCFUFOHFEKBI-UHFFFAOYSA-N 0.000 description 1
- WTEVQBCEXWBHNA-JXMROGBWSA-N geranial Chemical compound CC(C)=CCC\C(C)=C\C=O WTEVQBCEXWBHNA-JXMROGBWSA-N 0.000 description 1
- LPLVUJXQOOQHMX-QWBHMCJMSA-N glycyrrhizinic acid Chemical compound O([C@@H]1[C@@H](O)[C@H](O)[C@H](O[C@@H]1O[C@@H]1C([C@H]2[C@]([C@@H]3[C@@]([C@@]4(CC[C@@]5(C)CC[C@@](C)(C[C@H]5C4=CC3=O)C(O)=O)C)(C)CC2)(C)CC1)(C)C)C(O)=O)[C@@H]1O[C@H](C(O)=O)[C@@H](O)[C@H](O)[C@H]1O LPLVUJXQOOQHMX-QWBHMCJMSA-N 0.000 description 1
- 231100000869 headache Toxicity 0.000 description 1
- 230000006698 induction Effects 0.000 description 1
- 230000001939 inductive effect Effects 0.000 description 1
- 208000014674 injury Diseases 0.000 description 1
- 206010022437 insomnia Diseases 0.000 description 1
- 229930007744 linalool Natural products 0.000 description 1
- 235000011477 liquorice Nutrition 0.000 description 1
- 230000004060 metabolic process Effects 0.000 description 1
- 229910021645 metal ion Inorganic materials 0.000 description 1
- 210000003205 muscle Anatomy 0.000 description 1
- QIQXTHQIDYTFRH-UHFFFAOYSA-N octadecanoic acid Chemical compound CCCCCCCCCCCCCCCCCC(O)=O QIQXTHQIDYTFRH-UHFFFAOYSA-N 0.000 description 1
- OQCDKBAXFALNLD-UHFFFAOYSA-N octadecanoic acid Natural products CCCCCCCC(C)CCCCCCCCC(O)=O OQCDKBAXFALNLD-UHFFFAOYSA-N 0.000 description 1
- 239000004006 olive oil Substances 0.000 description 1
- 235000008390 olive oil Nutrition 0.000 description 1
- 208000026435 phlegm Diseases 0.000 description 1
- 238000000554 physical therapy Methods 0.000 description 1
- 239000000049 pigment Substances 0.000 description 1
- 150000008442 polyphenolic compounds Chemical class 0.000 description 1
- 235000013824 polyphenols Nutrition 0.000 description 1
- 230000001047 pyretic effect Effects 0.000 description 1
- 239000001397 quillaja saponaria molina bark Substances 0.000 description 1
- 238000007670 refining Methods 0.000 description 1
- 230000000552 rheumatic effect Effects 0.000 description 1
- 229930182490 saponin Natural products 0.000 description 1
- 150000007949 saponins Chemical class 0.000 description 1
- USDOQCCMRDNVAH-UHFFFAOYSA-N sigma-cadinene Natural products C1C=C(C)CC2C(C(C)C)CC=C(C)C21 USDOQCCMRDNVAH-UHFFFAOYSA-N 0.000 description 1
- 239000000741 silica gel Substances 0.000 description 1
- 229910002027 silica gel Inorganic materials 0.000 description 1
- 230000008591 skin barrier function Effects 0.000 description 1
- 210000004927 skin cell Anatomy 0.000 description 1
- 239000010676 star anise oil Substances 0.000 description 1
- 239000008117 stearic acid Substances 0.000 description 1
- 230000004936 stimulating effect Effects 0.000 description 1
- 238000003860 storage Methods 0.000 description 1
- 230000008093 supporting effect Effects 0.000 description 1
- 238000003786 synthesis reaction Methods 0.000 description 1
- 210000002435 tendon Anatomy 0.000 description 1
- TUNFSRHWOTWDNC-HKGQFRNVSA-N tetradecanoic acid Chemical compound CCCCCCCCCCCCC[14C](O)=O TUNFSRHWOTWDNC-HKGQFRNVSA-N 0.000 description 1
- 210000001519 tissue Anatomy 0.000 description 1
- 235000019165 vitamin E Nutrition 0.000 description 1
- 229940046009 vitamin E Drugs 0.000 description 1
- 239000011709 vitamin E Substances 0.000 description 1
- USDOQCCMRDNVAH-KKUMJFAQSA-N β-cadinene Chemical compound C1C=C(C)C[C@H]2[C@H](C(C)C)CC=C(C)[C@@H]21 USDOQCCMRDNVAH-KKUMJFAQSA-N 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
- A61K36/282—Artemisia, e.g. wormwood or sagebrush
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/23—Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
- A61K36/236—Ligusticum (licorice-root)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/25—Araliaceae (Ginseng family), e.g. ivy, aralia, schefflera or tetrapanax
- A61K36/258—Panax (ginseng)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/47—Euphorbiaceae (Spurge family), e.g. Ricinus (castorbean)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/53—Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
- A61K36/537—Salvia (sage)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/888—Araceae (Arum family), e.g. caladium, calla lily or skunk cabbage
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/16—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing nitrogen, e.g. nitro-, nitroso-, azo-compounds, nitriles, cyanates
- A61K47/18—Amines; Amides; Ureas; Quaternary ammonium compounds; Amino acids; Oligopeptides having up to five amino acids
- A61K47/183—Amino acids, e.g. glycine, EDTA or aspartame
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/42—Proteins; Polypeptides; Degradation products thereof; Derivatives thereof, e.g. albumin, gelatin or zein
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0014—Skin, i.e. galenical aspects of topical compositions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
Landscapes
- Health & Medical Sciences (AREA)
- Natural Medicines & Medicinal Plants (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Botany (AREA)
- Mycology (AREA)
- Microbiology (AREA)
- Medical Informatics (AREA)
- Biotechnology (AREA)
- Alternative & Traditional Medicine (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Dermatology (AREA)
- Inorganic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Medicines Containing Plant Substances (AREA)
Abstract
The invention belongs to the technical field of traditional Chinese medicines, has an IPC classification number of A61K36, and particularly relates to massage oil for relieving pain and a preparation method thereof. The raw materials for preparing the massage oil for relieving pain comprise, by weight: 37-65 parts of traditional Chinese medicine extract, 50-80 parts of essential oil composition, 1-2 parts of humectant, 0.6-1 part of additive and 74-130 parts of solvent. The preparation method comprises the following steps: the massage oil for relieving pain is prepared by adding a solvent, heating and refluxing to prepare a traditional Chinese medicine extract, fully stirring, homogenizing and mixing the traditional Chinese medicine extract and the essential oil composition, then adding a humectant and an additive, fully stirring, heating and mixing, and has the medicinal effects of being difficult to oxidize, good in stability, good in moisture retention, difficult to breed bacteria and deteriorate and capable of effectively relieving pain.
Description
Technical Field
The invention belongs to the technical field of traditional Chinese medicines, has an IPC classification number of A61K36, and particularly relates to massage oil for relieving pain and a preparation method thereof.
Background
The traditional Chinese medicine massage is a physical therapy, can dredge stasis and block channels and collaterals, quickens blood circulation, further promotes body metabolism, has the curative effects of relieving muscle tension and relieving body pain, presses bulges of local parts of a body caused by injury through proper acupoint massage, and reduces or eliminates the bulges through stroking and rubbing, thereby relieving swelling and pain.
The massage oil is coated on the body part needing to be massaged, the fingers, the palm, the elbows or other parts of the limbs are used for exerting force, and the massage oil is gradually pressed on the part or the acupuncture points to be massaged from light to heavy, so that the essential oil enters skin cells through massage and then enters blood vessels and tissues of the whole body to achieve the effects of relaxing tendons and collaterals, relaxing muscles and relieving fatigue and pressure.
Patent CN111821222A discloses agilawood massage oil and a preparation method thereof, wherein the preparation raw materials comprise mineral oil, olive oil, GTCC, fullerene, isopropyl myristate, stearic acid, essence oil and the like, the prepared agilawood massage oil has the effects of fresh smell, good use comfort, good skin fitting property and the like, but the mineral oil contained in the preparation raw materials can increase skin burden and has poor absorption.
Patent CN113230331A discloses a massage oil for relieving wandering pain and a preparation method thereof, the preparation raw materials of the massage oil comprise rhizoma cibotii, mistletoe, silkworm excrement, folium Photiniae, malus spectabilis, castor bean root, rhizoma ligustici wallichii, herba lycopi, caulis aristolochiae, polyporus artemisia capillaris, verbena, radix stephaniae tetrandrae, radix gentianae macrophyllae, chicken bone essence, liquorice and the like, and the massage oil has the effects of dispelling wind and promoting qi, promoting blood circulation and removing obstruction in channels, relieving swelling and relieving pain and the like, but the preparation raw materials of the massage oil only comprise traditional Chinese medicine extracts and base oil components, and are single in component, poor in stability of essential oil and short in storage time.
Disclosure of Invention
In order to solve the above problems, a first aspect of the present invention provides a massage oil for alleviating pain, which is prepared from the following raw materials in parts by weight: 37-65 parts of traditional Chinese medicine extract, 50-80 parts of essential oil composition, 1-2 parts of humectant, 0.6-1 part of additive and 74-130 parts of solvent.
As a preferable technical scheme, the traditional Chinese medicine extract comprises the following preparation raw materials in parts by weight: 10-15 parts of wormwood, 2-5 parts of pseudo-ginseng, 5-10 parts of Ligusticum wallichii, 5-10 parts of Salvia miltiorrhiza, 10-15 parts of garden balsam stem and 5-10 parts of rhizoma acori graminei, wherein the wormwood is dried leaves of Artemisia argyi Levl. Et Vant. Of Compositae, the pseudo-ginseng is dried roots and rhizomes of Panax notoginseng (Burk.) F.H.Chen of Araliaceae, the Ligusticum wallichii is dried rhizomes of Ligusticum chuanxiong Chuanxiong Hort. Of Umbelliferae, the Salvia miltiorrhiza is dried roots and rhizomes of Salvia miltiorrhiza Salvia millitrophic Bunge. Of Labiatae, the garden balsam stem is a whole plant of Vicia amoena Fisch. Of Vicia and dried rhizomes of white bead of Califolia Schwanella of Ericaceae, and the rhizome of Acorus gramineus of Leguminosae is dried whole plant Gaultheria galbana of Araliaceae;
as a preferred technical scheme, the essential oil composition is one or a compound of helichrysum essential oil, mint essential oil, perilla essential oil, marjoram essential oil, clove essential oil, black pepper essential oil, orange essential oil, sandalwood essential oil, bergamot essential oil, chamomile essential oil, orange flower essential oil, ylang-ylang essential oil, star anise essential oil, almond kernel oil, sweet almond oil, glycerin, avocado oil, babassu oil, grape seed oil and macadamia nut oil; as a more preferable technical scheme, the essential oil composition is a compound of star anise essential oil, ylang essential oil, babassu oil and macadamia nut oil, and the mass ratio of the essential oil composition to the macadamia nut oil is 0.7-0.9:0.3-0.5:18-25:22-31;
as a preferable technical scheme, the humectant is one or a compound of ginseng root extract, algae extract, phytosterol, glycine, hydrolyzed wheat protein, arginine, theanine and hydroxyproline;
as a more preferable technical scheme, the moisturizing agent is a compound of hydrolyzed wheat protein, hydroxyproline and arginine, and the mass ratio of the moisturizing agent to the hydrolyzed wheat protein is 1.2-1.4:0.2-0.5:0.3-0.5;
as a preferred technical scheme, the additive is one of or the compound of forsythia extract, perilla leaf extract, garlic extract pectin, mannan and tea extract;
as a more preferable technical scheme, the additive is a compound of perilla leaf extract and tea leaf extract, and the mass ratio of the additive to the tea leaf extract is 0.3-0.5:0.7-0.9.
As a preferred technical scheme, the solvent is a mixed solution of water and ethanol, and the mass ratio of the mixed solution is 1:0.8.
the second aspect of the invention provides a preparation method of massage oil for relieving pain, which comprises the following steps:
(1) The preparation method of the traditional Chinese medicine extract comprises the following steps: weighing 37-65 parts of traditional Chinese medicine extract, placing in a heating reflux device, adding in a solvent, heating and refluxing at the temperature of 60-70 ℃ for 3-4 h, filtering to obtain traditional Chinese medicine extract, and drying in a dryer at the temperature of 50-60 ℃ for 2-2.5 h;
(2) Adding the essential oil composition and the traditional Chinese medicine extract into a reaction kettle, and uniformly stirring at 50-55 ℃ for 15-20 min to fully homogenize and mix the essential oil composition and the traditional Chinese medicine extract to obtain a mixture a for later use;
(3) Adding the humectant and the additive into the mixture a in the reaction kettle in the step (2), stirring, heating and mixing at the stirring temperature of 80-85 ℃ for 20-30 min, cooling the reaction kettle to 25-30 ℃ to prepare a mixture b, taking out the mixture b in the reaction kettle, and performing sterilization treatment to prepare the massage oil for relieving pain.
Advantageous effects
(1) The massage oil for relieving pain is prepared by mixing the traditional Chinese medicine extract, the solvent, the essential oil composition, the humectant and the additive, and has the medicinal effects of difficult oxidation, good stability, good moisture retention, difficult breeding of bacteria and deterioration and effective pain relief.
(2) The medicinal effect of the prepared massage oil for relieving pain can be improved by adding the traditional Chinese medicine extract, and particularly when the traditional Chinese medicine extract is wormwood, pseudo-ginseng, ligusticum wallichii, salvia miltiorrhiza, garden balsam stem and rhizoma acori graminei, the prepared massage oil for relieving pain can be applied to affected parts to effectively relieve body pain through massage. The reasons can be that the wormwood is pungent, bitter and warm in nature, has the effects of dispelling cold, relieving pain, relieving skin itch and the like, the pseudo-ginseng is sweet, slightly bitter and warm in nature, has the effects of dissipating blood stasis, stopping bleeding, diminishing swelling, relieving pain and the like, can treat symptoms such as traumatic bleeding, thoracoabdominal pain, traumatic swelling and pain and the like, the ligusticum wallichii is pungent and warm in nature, has the effects of activating blood circulation, promoting the circulation of qi, dispelling wind, relieving pain and the like, can relieve symptoms such as abdominal pain, chest and hypochondrium pricking pain, traumatic swelling pain, headache, rheumatic arthralgia and the like, and the salvia miltiorrhiza is bitter in nature and slightly cold in nature, has the medicinal effects of removing blood stasis, relieving pain, clearing heart, relieving restlessness and the like, can be used for irregular menstruation, amenorrhea, dysmenorrhea, symptom accumulation, chest and abdominal pricking pain, pyretic arthralgia, sore and sore swelling pain, vexation and insomnia; the Chinese medicinal composition has the medicinal effects of resolving dampness, stimulating appetite, inducing resuscitation, eliminating phlegm, refreshing mind and benefiting intelligence, and can effectively relieve body pain through synergistic effect after the medicaments are combined.
(3) The invention can further improve the medicinal efficacy and the oxidation stability of the massage oil for relieving pain by adding the essential oil composition, particularly the essential oil composition is the compound of star anise essential oil, ylang essential oil, babassu oil and macadamia nut oil, and the mass ratio of the essential oil composition is 0.7-0.9:0.3-0.5:18-25:22-31, the massage oil for relieving pain has excellent medicinal effect and oxidation stability, and may be prepared by enriching the anise essential oil with substances such as alpha-pinene, anisaldehyde, beta-pinene, camphene, linalool, cis-and trans-anisyl alcohols, crocus sativus, acetoanisol and the like, and can relieve muscle tension and prevent spasm or pain, enriching the ylang essential oil with substances such as beta-caryophyllene, cadinene, benzyl benzoate, alpha-humulus and the like, has anti-inflammatory and relaxing effects, can relieve local body pain caused by fatigue, and relax muscle tension, enriching the babassu oil with vitamin E, lauric acid and myristic acid, can inhibit the oxidation of the effective components of the essential oil and moisten skin, and containing a large amount of antioxidants, removes hydroxyl radicals and superoxide anion radicals, has synergistic effect between the essential oil composition and the traditional Chinese medicine composition, and active components in the essential oil composition can fully diffuse into the traditional Chinese medicine composition molecules, and can effectively inhibit the oxidation of the traditional Chinese medicine effective components, so that the prepared massage oil has excellent medicinal effect of relieving pain. In addition, the essential oil composition and the additive are compounded by perilla leaf extract and tea extract, and the mass ratio of the essential oil composition to the additive is 0.3-0.5:0.7-0.9, the synergistic effect is achieved, the physicochemical stability of the prepared pain relieving massage oil can be effectively maintained, and the medicinal efficacy of the massage oil can be further maintained, the perilla leaf extract is rich in perillaldehyde and citral and has a broad-spectrum antibacterial effect, the tea leaf extract is rich in tea polyphenol, tea pigment, alkaloid, tea saponin and epigallocatechin gallate and has the effects of resisting bacteria, viruses and the like, the bacteria in the prepared pain relieving massage oil can be effectively eliminated, the synergistic effect of the essential oil composition is achieved, the physicochemical stability of the massage oil can be effectively maintained, the effective components of the massage oil are not easy to deteriorate, and the medicinal efficacy of the massage oil can be further maintained.
(4) The massage oil for relieving pain has good moisture retention by adding the humectant, and particularly, the humectant is a compound of hydrolyzed wheat protein, hydroxyproline and arginine, and the mass ratio of the humectant to the total weight of the massage oil is 1.2-1.4:0.2-0.5:0.3-0.5, the prepared massage oil for relieving pain has excellent moisture retention, probably because hydrolyzed wheat protein contains rich cystine, and has the effects of moisturizing, softening and refining skin and moistening skin, hydroxyproline can prevent macromolecular crosslinking in the skin due to the action of free radicals, so that the activity of crosslinked proline hydroxylase is reduced, the content of hydroxyproline is inhibited from being reduced, the synthesis of collagen is promoted, the collagen peptide bonds and the elastic net for supporting the skin are prevented from being broken, the skin barrier is strengthened, the skin is kept moist and smooth, arginine forms the minimum unit of protein, can completely penetrate epithelial cells and directly reach fibroblasts in the dermis layer to play a role, the massage oil has biological activity, the skin quality is obviously improved, the barrier function of the skin is not influenced, and after the hydrolyzed wheat protein, the hydroxyproline and the arginine are compounded, excessive divalent metal ions in the skin can be effectively inhibited from reacting with collagen in the skin, so that the collagen fibers and the elastic fibers in the skin have enough chelation and moisture to keep the skin.
(5) The massage oil for relieving pain is prepared by adding a solvent, heating and refluxing to prepare a traditional Chinese medicine extract, fully stirring and homogenizing the traditional Chinese medicine extract and the essential oil composition, then adding a humectant and an additive, fully stirring, heating and mixing, and has the medicinal effects of difficult oxidation, good stability, good moisture retention, difficult bacterial breeding and deterioration and effective pain relief.
Detailed Description
Example 1
Embodiment 1 provides a massage oil for relieving pain, which is prepared from the following raw materials in parts by weight: 37 parts of traditional Chinese medicine extract, 50 parts of essential oil composition, 1 part of humectant, 0.6 part of additive and 74 parts of solvent.
The traditional Chinese medicine extract is prepared from the following raw materials in parts by weight: 10 parts of wormwood, 2 parts of pseudo-ginseng, 5 parts of ligusticum wallichii, 5 parts of salvia miltiorrhiza, 10 parts of garden balsam stem and 5 parts of rhizoma acori graminei;
the essential oil composition is a compound of star anise essential oil, ylang essential oil, babassu oil and macadamia nut oil, and the mass ratio of the essential oil composition to the macadamia nut oil is 0.7:0.3:18:22, star anise essential oil CAS number 8007-70-3, purchased from shanghai source leaf biotechnology limited, ylang essential oil CAS number 8006-81-3, purchased from zhong new materials limited, jiang west, babassu oil CAS number 91078-92-1, purchased from shanghai dingfen chemical technology limited, australian nut oil CAS number 129811-19-4, purchased from siebol quan chemical (shanghai) limited;
the humectant is a compound of hydrolyzed wheat protein, hydroxyproline and arginine, and the mass ratio of the humectant to the hydrolyzed wheat protein is 1.2:0.2:0.3, hydrolyzed wheat protein CAS number 70084-87-6, from Fushan dao qi Biotech Co., ltd, hydroxyproline CAS number 618-27-9, from Shanghai Merlin Biotech Co., ltd, arginine CAS number 74-79-3, from Shaanxi Chengming Biotech Co., ltd;
the additive is a compound of perilla leaf extract and tea leaf extract, and the mass ratio of the additive to the tea leaf extract is 0.3:0.7, the CAS number of the perilla leaf extract is 90082-51-2, purchased from Rigiett Biotechnology Limited in Shenzhen, the CAS number of the tea leaf extract is 144207-58-9, purchased from Changshajar Zhen Biotechnology Limited;
the solvent is a mixed solution of water and ethanol, and the mass ratio of the mixed solution to the solvent is 1:0.8, ethanol CAS number 64-17-5, available from Shanghai Allantin Biotechnology Ltd.
The second aspect of the invention provides a preparation method of massage oil for relieving pain, which comprises the following steps:
(1) The preparation method of the traditional Chinese medicine extract comprises the following steps: weighing 37 parts of the traditional Chinese medicine extract, placing the traditional Chinese medicine extract in a heating reflux device, adding a solvent, heating and refluxing at the temperature of 60 ℃ for 3 hours, filtering to obtain a traditional Chinese medicine extracting solution, placing the traditional Chinese medicine extracting solution in a dryer for drying at the temperature of 50 ℃ for 2 hours;
(2) Adding the essential oil composition and the Chinese medicinal extract into a reaction kettle, and stirring uniformly at 50 deg.C for 15min to obtain mixture a;
(3) And (3) adding the humectant and the additive into the mixture a in the reaction kettle in the step (2), stirring, heating and mixing, wherein the stirring temperature is 80 ℃, the stirring time is 20min, then cooling the reaction kettle to 25 ℃, preparing a mixture b, taking out the mixture b from the reaction kettle, and sterilizing to prepare the massage oil for relieving pain.
Example 2
Embodiment 2 provides a massage oil for relieving pain, which is prepared from the following raw materials in parts by weight: 65 parts of traditional Chinese medicine extract, 80 parts of essential oil composition, 2 parts of humectant, 1 part of additive and 130 parts of solvent.
The traditional Chinese medicine extract is prepared from the following raw materials in parts by weight: 10-15 parts of wormwood, 2-5 parts of pseudo-ginseng, 5-10 parts of ligusticum wallichii, 5-10 parts of salvia miltiorrhiza, 10-15 parts of garden balsam stem and 5-10 parts of rhizoma acori graminei;
the essential oil composition is a compound of star anise essential oil, ylang-ylang essential oil, babassu oil and macadamia nut oil, and the mass ratio of the essential oil composition to the macadamia nut oil is 0.9:0.5:25:31, anise star anise oil CAS number 8007-70-3, from shanghai yuan leaf biotechnology limited, ylang oil CAS number 8006-81-3, from zhonghuan new materials limited in jiang west, babassu oil CAS number 91078-92-1, from shanghai dingfen chemical technology limited, macadamia nut oil CAS number 129811-19-4, from shanbai total chemistry (shanghai) limited;
the humectant is a compound of hydrolyzed wheat protein, hydroxyproline and arginine, and the mass ratio of the humectant to the hydrolyzed wheat protein is 1.4:0.5:0.5, hydrolyzed wheat protein CAS number 70084-87-6, from Fushan dao qi Biotech Co., ltd, hydroxyproline CAS number 618-27-9, from Shanghai Michelin Biochemical technology Co., ltd, arginine CAS number 74-79-3, from Shaanxi Chengming Biotechnology Co., ltd;
the additive is a compound of perilla leaf extract and tea leaf extract, and the mass ratio of the additive to the tea leaf extract is 0.5:0.9, the CAS number of the perilla leaf extract is 90082-51-2, purchased from Rigiett biotechnology limited of Shenzhen city, the CAS number of the tea leaf extract is 144207-58-9, purchased from Changshajar Zhen biotechnology limited;
the solvent is a mixed solution of water and ethanol, and the mass ratio of the mixed solution to the solvent is 1:0.8, ethanol CAS number 64-17-5, available from Shanghai Allantin Biotechnology Ltd.
The second aspect of the invention provides a preparation method of massage oil for relieving pain, which comprises the following steps:
(1) The preparation method of the traditional Chinese medicine extract comprises the following steps: weighing 65 parts of the traditional Chinese medicine extract, placing the traditional Chinese medicine extract in a heating reflux device, adding a solvent, heating and refluxing at the temperature of 70 ℃ for 4 hours, filtering to obtain a traditional Chinese medicine extracting solution, placing the traditional Chinese medicine extracting solution in a drier for drying at the temperature of 60 ℃ for 2.5 hours;
(2) Adding the essential oil composition and the Chinese medicinal extract into a reaction kettle, and stirring uniformly at 55 deg.C for 20min to obtain mixture a;
(3) Adding the humectant and the additive into the mixture a in the reaction kettle in the step (2), stirring, heating and mixing, wherein the stirring temperature is 85 ℃, the stirring time is 30min, then cooling the reaction kettle to 30 ℃, preparing a mixture b, taking out the mixture b in the reaction kettle, and performing sterilization treatment to prepare the mixture A for relieving pain
Example 3
Embodiment 3 provides a massage oil for relieving pain, which is prepared from the following raw materials in parts by weight: 50 parts of traditional Chinese medicine extract, 70 parts of essential oil composition, 1.5 parts of humectant, 0.8 part of additive and 100 parts of solvent.
The traditional Chinese medicine extract is prepared from the following raw materials in parts by weight: 12 parts of wormwood, 3 parts of pseudo-ginseng, 8 parts of ligusticum wallichii, 8 parts of salvia miltiorrhiza, 12 parts of garden balsam stem and 7 parts of rhizoma acori graminei;
the essential oil composition is a compound of star anise essential oil, ylang essential oil, babassu oil and macadamia nut oil, and the mass ratio of the essential oil composition to the macadamia nut oil is 0.8:0.4:20:28, the star anise essential oil CAS number is 8007-70-3, purchased from Shanghai leaf Biotechnology Co., ltd, the ylang essential oil CAS number is 8006-81-3, purchased from Jiangxi Zhongzhong New Material Co., ltd, the babassu oil CAS number is 91078-92-1, purchased from Shanghai Dingfen chemical technology Co., ltd, the Australian nut oil CAS number is 129811-19-4, and purchased from Shibaiquan chemical (Shanghai) Co., ltd;
the humectant is a compound of hydrolyzed wheat protein, hydroxyproline and arginine, and the mass ratio of the humectant to the hydrolyzed wheat protein is 1.3:0.4:0.4, hydrolyzed wheat protein CAS number 70084-87-6, from Fushan dao qi Biotech Co., ltd, hydroxyproline CAS number 618-27-9, from Shanghai Merlin Biotech Co., ltd, arginine CAS number 74-79-3, from Shaanxi Chengming Biotech Co., ltd;
the additive is a compound of perilla leaf extract and tea leaf extract, and the mass ratio of the additive to the tea leaf extract is 0.4:0.8, the CAS number of the perilla leaf extract is 90082-51-2, purchased from Rigiett Biotech Co., ltd, shenzhen, the CAS number of the tea leaf extract is 144207-58-9, purchased from Changshajar Zhen Biotech Co., ltd. .
The solvent is a mixed solution of water and ethanol, and the mass ratio of the mixed solution to the solvent is 1:0.8, ethanol CAS number 64-17-5, available from Shanghai Allantin Biotechnology Ltd.
The second aspect of the invention provides a preparation method of massage oil for relieving pain, which comprises the following steps:
(1) The preparation method of the traditional Chinese medicine extract comprises the following steps: weighing 50 parts of the traditional Chinese medicine extract, placing in a heating reflux device, adding a solvent, heating and refluxing at the temperature of 65 ℃ for 3.5 hours, filtering to obtain a traditional Chinese medicine extract, and placing the traditional Chinese medicine extract in a dryer for drying at the temperature of 55 ℃ for 2.2 hours;
(2) Adding the essential oil composition and the Chinese medicinal extract into a reaction kettle, and stirring uniformly at 52 deg.C for 18min to obtain mixture a;
(3) Adding the humectant and the additive into the mixture a in the reaction kettle in the step (2), stirring, heating and mixing at 82 ℃ for 25min, cooling the reaction kettle to 28 ℃ to obtain a mixture b, taking out the mixture b from the reaction kettle, and sterilizing to obtain the massage oil for relieving pain.
Comparative example 1
Comparative example 1 provides a massage oil for relieving pain, which is prepared from the following raw materials in parts by weight: 65 parts of traditional Chinese medicine extract, 80 parts of essential oil composition, 2 parts of humectant, 1 part of additive and 130 parts of solvent.
The traditional Chinese medicine extract is prepared from the following raw materials in parts by weight: 10-15 parts of wormwood, 2-5 parts of pseudo-ginseng, 5-10 parts of ligusticum wallichii, 5-10 parts of salvia miltiorrhiza, 10-15 parts of garden balsam stem and 5-10 parts of rhizoma acori graminei;
the essential oil composition is a compound of star anise essential oil and cananga odorata essential oil, and the mass ratio of the essential oil composition to the essential oil composition is 25:31, the star anise essential oil CAS number is 8007-70-3, purchased from Shanghai Yuye Biotech Co., ltd, and the ylang essential oil CAS number is 8006-81-3, purchased from Jiangxi Zhongzhong New materials Co., ltd;
the humectant is a compound of hydrolyzed wheat protein, hydroxyproline and arginine, and the mass ratio of the humectant to the hydrolyzed wheat protein is 1.4:0.5:0.5, hydrolyzed wheat protein CAS number 70084-87-6, from Fushan dao qi Biotech Co., ltd, hydroxyproline CAS number 618-27-9, from Shanghai Michelin Biochemical technology Co., ltd, arginine CAS number 74-79-3, from Shaanxi Chengming Biotechnology Co., ltd;
the additive is a compound of perilla leaf extract and tea leaf extract, and the mass ratio of the additive to the tea leaf extract is 0.5:0.9, the CAS number of the perilla leaf extract is 90082-51-2, purchased from Rigiett biotechnology limited of Shenzhen city, the CAS number of the tea leaf extract is 144207-58-9, purchased from Changshajar Zhen biotechnology limited;
the solvent is a mixed solution of water and ethanol, and the mass ratio of the mixed solution to the solvent is 1:0.8, ethanol CAS number 64-17-5, available from Shanghai Allantin Biotechnology Ltd.
The second aspect of the invention provides a preparation method of massage oil for relieving pain, which comprises the following steps:
(1) The preparation method of the traditional Chinese medicine extract comprises the following steps: weighing 65 parts of the traditional Chinese medicine extract, placing the traditional Chinese medicine extract in a heating reflux device, adding a solvent, heating and refluxing at the temperature of 70 ℃ for 4 hours, filtering to obtain a traditional Chinese medicine extracting solution, placing the traditional Chinese medicine extracting solution in a drier for drying at the temperature of 60 ℃ for 2.5 hours;
(2) Adding the essential oil composition and the Chinese medicinal extract into a reaction kettle, and stirring uniformly at 55 deg.C for 20min to obtain mixture a;
(3) Adding the humectant and the additive into the mixture a in the reaction kettle in the step (2), stirring, heating and mixing at 85 ℃ for 30min, cooling the reaction kettle to 30 ℃ to obtain a mixture b, taking out the mixture b from the reaction kettle, and performing sterilization treatment to obtain the massage oil for relieving pain.
Comparative example 2
Comparative example 2 provides a massage oil for relieving pain, which is prepared from the following raw materials in parts by weight: 65 parts of traditional Chinese medicine extract, 80 parts of essential oil composition, 2 parts of humectant, 1 part of additive and 130 parts of solvent.
The traditional Chinese medicine extract is prepared from the following raw materials in parts by weight: 10-15 parts of wormwood, 2-5 parts of pseudo-ginseng, 5-10 parts of ligusticum wallichii, 5-10 parts of salvia miltiorrhiza, 10-15 parts of garden balsam stem and 5-10 parts of rhizoma acori graminei;
the essential oil composition is babassu oil, the CAS number of the babassu oil is 91078-92-1, and the babassu oil is purchased from Shanghainefin chemical technology Co., ltd;
the humectant is a compound of hydrolyzed wheat protein, hydroxyproline and arginine, and the mass ratio of the humectant to the hydrolyzed wheat protein is 1.4:0.5:0.5, hydrolyzed wheat protein CAS number 70084-87-6, from Fushan dao qi Biotech Co., ltd, hydroxyproline CAS number 618-27-9, from Shanghai Michelin Biochemical technology Co., ltd, arginine CAS number 74-79-3, from Shaanxi Chengming Biotechnology Co., ltd;
the additive is a compound of perilla leaf extract and tea leaf extract, and the mass ratio of the additive to the tea leaf extract is 0.5:0.9, the CAS number of the perilla leaf extract is 90082-51-2, purchased from Rigiett biotechnology limited of Shenzhen city, the CAS number of the tea leaf extract is 144207-58-9, purchased from Changshajar Zhen biotechnology limited;
the solvent is a mixed solution of water and ethanol, and the mass ratio of the mixed solution to the solvent is 1:0.8, ethanol CAS number 64-17-5, available from Shanghai Allantin Biotechnology Ltd.
The second aspect of the invention provides a preparation method of massage oil for relieving pain, which comprises the following steps:
(1) The preparation method of the traditional Chinese medicine extract comprises the following steps: weighing 65 parts of the traditional Chinese medicine extract, placing the traditional Chinese medicine extract in a heating reflux device, adding a solvent, heating and refluxing at the temperature of 70 ℃ for 4 hours, filtering to obtain a traditional Chinese medicine extracting solution, placing the traditional Chinese medicine extracting solution in a drier for drying at the temperature of 60 ℃ for 2.5 hours;
(2) Adding the essential oil composition and the Chinese medicinal extract into a reaction kettle, and stirring uniformly at 55 deg.C for 20min to obtain mixture a;
(3) Adding the humectant and the additive into the mixture a in the reaction kettle in the step (2), stirring, heating and mixing at 85 ℃ for 30min, cooling the reaction kettle to 30 ℃ to obtain a mixture b, taking out the mixture b from the reaction kettle, and performing sterilization treatment to obtain the massage oil for relieving pain.
Comparative example 3
Comparative example 3 provides a massage oil for relieving pain, which is prepared from the following raw materials in parts by weight: 65 parts of traditional Chinese medicine extract, 80 parts of essential oil composition, 2 parts of humectant, 1 part of additive and 130 parts of solvent.
The traditional Chinese medicine extract is prepared from the following raw materials in parts by weight: 10-15 parts of wormwood, 2-5 parts of pseudo-ginseng, 5-10 parts of ligusticum wallichii, 5-10 parts of salvia miltiorrhiza, 10-15 parts of garden balsam stem and 5-10 parts of rhizoma acori graminei;
the essential oil composition is a compound of star anise essential oil, ylang essential oil, babassu oil and macadamia nut oil, and the mass ratio of the essential oil composition to the macadamia nut oil is 0.7:0.1:10:15, star anise essential oil CAS number 8007-70-3, purchased from shanghai source leaf biotechnology limited, ylang essential oil CAS number 8006-81-3, purchased from zhong new materials limited, jiang west, babassu oil CAS number 91078-92-1, purchased from shanghai dingfen chemical technology limited, australian nut oil CAS number 129811-19-4, purchased from siebol quan chemical (shanghai) limited;
the humectant is a compound of hydrolyzed wheat protein, hydroxyproline and arginine, and the mass ratio of the humectant to the hydrolyzed wheat protein is 1.4:0.5:0.5, hydrolyzed wheat protein CAS number 70084-87-6, from Virginia Virginiana Biotechnology Co., ltd, hydroxyproline CAS number 618-27-9, from Shanghai Michelin Biochemical technology Co., ltd, arginine CAS number 74-79-3, from Shaanxi Chengming Biotechnology Co., ltd;
the additive is a compound of perilla leaf extract and tea extract, and the mass ratio of the additive to the tea extract is 0.5:0.9, the CAS number of the perilla leaf extract is 90082-51-2, purchased from Rigiett biotechnology limited of Shenzhen city, the CAS number of the tea leaf extract is 144207-58-9, purchased from Changshajar Zhen biotechnology limited;
the solvent is a mixed solution of water and ethanol, and the mass ratio of the mixed solution to the solvent is 1:0.8, ethanol CAS number 64-17-5, available from Shanghai Allantin Biotechnology Ltd.
The second aspect of the invention provides a preparation method of massage oil for relieving pain, which comprises the following steps:
(1) The preparation method of the traditional Chinese medicine extract comprises the following steps: weighing 65 parts of the traditional Chinese medicine extract, placing the traditional Chinese medicine extract in a heating reflux device, adding a solvent, heating reflux temperature is 70 ℃, heating reflux time is 4 hours, filtering to obtain a traditional Chinese medicine extracting solution, placing the traditional Chinese medicine extracting solution in a dryer for drying, drying temperature is 60 ℃, and drying time is 2.5 hours;
(2) Adding the essential oil composition and the Chinese medicinal extract into a reaction kettle, and stirring uniformly at 55 deg.C for 20min to obtain mixture a;
(3) Adding the humectant and the additive into the mixture a in the reaction kettle in the step (2), stirring, heating and mixing at 85 ℃ for 30min, cooling the reaction kettle to 30 ℃ to obtain a mixture b, taking out the mixture b from the reaction kettle, and performing sterilization treatment to obtain the massage oil for relieving pain.
Comparative example 4
Comparative example 4 provides a massage oil for relieving pain, which is prepared from the following raw materials in parts by weight: 65 parts of traditional Chinese medicine extract, 80 parts of essential oil composition, 2 parts of humectant, 1 part of additive and 130 parts of solvent.
The traditional Chinese medicine extract is prepared from the following raw materials in parts by weight: 10-15 parts of wormwood, 2-5 parts of pseudo-ginseng, 5-10 parts of ligusticum wallichii, 5-10 parts of salvia miltiorrhiza, 10-15 parts of garden balsam stem and 5-10 parts of rhizoma acori graminei;
the essential oil composition is a compound of star anise essential oil, ylang essential oil, babassu oil and macadamia nut oil, and the mass ratio of the essential oil composition to the macadamia nut oil is 0.9:0.5:25:31, star anise essential oil CAS number 8007-70-3, purchased from shanghai source leaf biotechnology limited, ylang essential oil CAS number 8006-81-3, purchased from zhong new materials limited, jiang west, babassu oil CAS number 91078-92-1, purchased from shanghai dingfen chemical technology limited, australian nut oil CAS number 129811-19-4, purchased from siebol quan chemical (shanghai) limited;
the humectant is hydrolyzed wheat protein, the CAS number of the hydrolyzed wheat protein is 70084-87-6, and the hydrolyzed wheat protein is purchased from Fushan dao qi Biotech limited;
the additive is a compound of perilla leaf extract and tea leaf extract, and the mass ratio of the additive to the tea leaf extract is 0.5:0.9, the CAS number of the perilla leaf extract is 90082-51-2, purchased from Rigiett biotechnology limited of Shenzhen city, the CAS number of the tea leaf extract is 144207-58-9, purchased from Changshajar Zhen biotechnology limited;
the solvent is a mixed solution of water and ethanol, and the mass ratio of the mixed solution to the solvent is 1:0.8, ethanol CAS number 64-17-5, available from Shanghai Allantin Biotechnology Ltd.
The second aspect of the invention provides a preparation method of massage oil for relieving pain, which comprises the following steps:
(1) The preparation method of the traditional Chinese medicine extract comprises the following steps: weighing 65 parts of the traditional Chinese medicine extract, placing the traditional Chinese medicine extract in a heating reflux device, adding a solvent, heating and refluxing at the temperature of 70 ℃ for 4 hours, filtering to obtain a traditional Chinese medicine extracting solution, placing the traditional Chinese medicine extracting solution in a drier for drying at the temperature of 60 ℃ for 2.5 hours;
(2) Adding the essential oil composition and the traditional Chinese medicine extract into a reaction kettle, and stirring uniformly at 55 ℃ for 20min to fully homogenize and mix the essential oil composition and the traditional Chinese medicine extract to obtain a mixture a for later use;
(3) Adding the humectant and the additive into the mixture a in the reaction kettle in the step (2), stirring, heating and mixing at 85 ℃ for 30min, cooling the reaction kettle to 30 ℃ to obtain a mixture b, taking out the mixture b from the reaction kettle, and performing sterilization treatment to obtain the massage oil for relieving pain.
Comparative example 5
Comparative example 5 provides a massage oil for relieving pain, which is prepared from the following raw materials in parts by weight: 65 parts of traditional Chinese medicine extract, 80 parts of essential oil composition, 2 parts of humectant, 1 part of additive and 130 parts of solvent.
The traditional Chinese medicine extract is prepared from the following raw materials in parts by weight: 10-15 parts of wormwood, 2-5 parts of pseudo-ginseng, 5-10 parts of ligusticum wallichii, 5-10 parts of salvia miltiorrhiza, 10-15 parts of garden balsam stem and 5-10 parts of rhizoma acori graminei;
the essential oil composition is a compound of star anise essential oil, ylang essential oil, babassu oil and macadamia nut oil, and the mass ratio of the essential oil composition to the macadamia nut oil is 0.9:0.5:25:31, star anise essential oil CAS number 8007-70-3, purchased from shanghai source leaf biotechnology limited, ylang essential oil CAS number 8006-81-3, purchased from zhong new materials limited, jiang west, babassu oil CAS number 91078-92-1, purchased from shanghai dingfen chemical technology limited, australian nut oil CAS number 129811-19-4, purchased from siebol quan chemical (shanghai) limited;
the humectant is a compound of hydrolyzed wheat protein and arginine, and the mass ratio of the humectant to the hydrolyzed wheat protein is 1.4:0.5, hydrolyzed wheat protein CAS number 70084-87-6, from Foshan dao qi biotech Co., ltd, arginine CAS number 74-79-3, from Shaanxi morning Ming biotech Co., ltd;
the additive is a compound of perilla leaf extract and tea extract, and the mass ratio of the additive to the tea extract is 0.5:0.9, the CAS number of the perilla leaf extract is 90082-51-2, purchased from Rigiett biotechnology limited of Shenzhen city, the CAS number of the tea leaf extract is 144207-58-9, purchased from Changshajar Zhen biotechnology limited;
the solvent is a mixed solution of water and ethanol, and the mass ratio of the mixed solution to the solvent is 1:0.8, ethanol CAS number 64-17-5, available from Shanghai Allantin Biotechnology Ltd.
The second aspect of the invention provides a preparation method of massage oil for relieving pain, which comprises the following steps:
(1) The preparation method of the traditional Chinese medicine extract comprises the following steps: weighing 65 parts of the traditional Chinese medicine extract, placing the traditional Chinese medicine extract in a heating reflux device, adding a solvent, heating and refluxing at the temperature of 70 ℃ for 4 hours, filtering to obtain a traditional Chinese medicine extracting solution, placing the traditional Chinese medicine extracting solution in a drier for drying at the temperature of 60 ℃ for 2.5 hours;
(2) Adding the essential oil composition and the Chinese medicinal extract into a reaction kettle, and stirring uniformly at 55 deg.C for 20min to obtain mixture a;
(3) And (3) adding the humectant and the additive into the mixture a in the reaction kettle in the step (2), stirring, heating and mixing, wherein the stirring temperature is 85 ℃, the stirring time is 30min, then cooling the reaction kettle to 30 ℃, preparing a mixture b, taking out the mixture b from the reaction kettle, and sterilizing to prepare the massage oil for relieving pain.
Comparative example 6
Comparative example 6 provides a massage oil for relieving pain, which is prepared from the following raw materials in parts by weight: 65 parts of traditional Chinese medicine extract, 80 parts of essential oil composition, 2 parts of humectant, 1 part of additive and 130 parts of solvent.
The traditional Chinese medicine extract is prepared from the following raw materials in parts by weight: 10-15 parts of wormwood, 2-5 parts of pseudo-ginseng, 5-10 parts of ligusticum wallichii, 5-10 parts of salvia miltiorrhiza, 10-15 parts of garden balsam stem and 5-10 parts of rhizoma acori graminei;
the essential oil composition is a compound of star anise essential oil, ylang-ylang essential oil, babassu oil and macadamia nut oil, and the mass ratio of the essential oil composition to the macadamia nut oil is 0.9:0.5:25:31, star anise essential oil CAS number 8007-70-3, purchased from shanghai source leaf biotechnology limited, ylang essential oil CAS number 8006-81-3, purchased from zhong new materials limited, jiang west, babassu oil CAS number 91078-92-1, purchased from shanghai dingfen chemical technology limited, australian nut oil CAS number 129811-19-4, purchased from siebol quan chemical (shanghai) limited;
the humectant is a compound of hydrolyzed wheat protein, hydroxyproline and arginine, and the mass ratio of the humectant to the hydrolyzed wheat protein is 1.2:0.1:0.1, hydrolyzed wheat protein CAS number 70084-87-6, from Fushan dao qi Biotech Co., ltd, hydroxyproline CAS number 618-27-9, from Shanghai Merlin Biotech Co., ltd, arginine CAS number 74-79-3, from Shaanxi Chengming Biotech Co., ltd;
the additive is a compound of perilla leaf extract and tea leaf extract, and the mass ratio of the additive to the tea leaf extract is 0.5:0.9, the CAS number of the perilla leaf extract is 90082-51-2, purchased from Rigiett biotechnology limited of Shenzhen city, the CAS number of the tea leaf extract is 144207-58-9, purchased from Changshajar Zhen biotechnology limited;
the solvent is a mixed solution of water and ethanol, and the mass ratio of the mixed solution to the solvent is 1:0.8, ethanol CAS number 64-17-5, available from Shanghai Allantin Biotechnology Ltd.
The second aspect of the invention provides a preparation method of massage oil for relieving pain, which comprises the following steps:
(1) The preparation method of the traditional Chinese medicine extract comprises the following steps: weighing 65 parts of traditional Chinese medicine extract, placing in a solvent, heating and refluxing at the temperature of 70 ℃ for 4 hours, filtering to obtain a traditional Chinese medicine extracting solution, and placing the traditional Chinese medicine extracting solution into a dryer for drying at the temperature of 60 ℃ for 2.5 hours;
(2) Adding the essential oil composition and the Chinese medicinal extract into a reaction kettle, and stirring uniformly at 55 deg.C for 20min to obtain mixture a;
(3) Adding the humectant and the additive into the mixture a in the reaction kettle in the step (2), stirring, heating and mixing at 85 ℃ for 30min, cooling the reaction kettle to 30 ℃ to obtain a mixture b, taking out the mixture b from the reaction kettle, and performing sterilization treatment to obtain the massage oil for relieving pain.
And (3) performance testing:
1: moisture retention
The massage oil for relieving pain prepared in examples 1 to 3 and comparative examples 4 to 6 is respectively placed in an open weighing bottle, deionized water with the weight of 15 percent of the sample is added, the mixture is placed in a drier with dry silica gel, and after the mixture is placed for 8 hours, 18 hours, 28 hours and 40 hours, the formula is passed: moisture retention rate (%) = H 2 /H 1 *100％，H 1 For the mass of water added, H 2 After standing for 1h, the remaining water in the bottle was weighed. The calculation results are shown in table 1:
the result shows that the humectant is a compound of hydrolyzed wheat protein, hydroxyproline and arginine, and the mass ratio of the humectant is (1.2-1.4): 0.2-0.5:0.3 to 0.5, the obtained massage oil for relieving pain has excellent moisture retention.
2. Oxidation resistance
The oxidation induction time of the pain relieving massage oil obtained in examples 1 to 3 and comparative examples 1 to 3 was measured at 110 ℃, 120 ℃, 130 ℃, 140 ℃ using a fat oxidation stability measuring instrument (Switzerland 743 type) and the shelf life of the obtained pain relieving massage oil was derived, and the oxidation resistance temperature results of the obtained pain relieving massage oil are shown in Table 2.
The essential oil composition is a compound of star anise essential oil, ylang essential oil, babassu oil and macadamia nut oil, and the mass ratio of the essential oil composition to the macadamia nut oil is 0.7-0.9:0.3-0.5:18-25:22-31, the prepared massage oil for relieving pain has excellent oxidation resistance and stability.
Claims (10)
1. The massage oil for relieving pain is characterized by comprising the following raw materials in parts by weight: 37-65 parts of traditional Chinese medicine extract, 50-80 parts of essential oil composition, 1-2 parts of humectant, 0.6-1 part of additive and 74-130 parts of solvent.
2. The massage oil for relieving pain of claim 1, wherein the raw materials comprise, by weight: 65 parts of traditional Chinese medicine extract, 80 parts of essential oil composition, 2 parts of humectant, 1 part of additive and 130 parts of solvent.
3. The massage oil for relieving pain as claimed in claim 1 or 2, wherein the Chinese herbal medicine extract is prepared from the following raw materials in parts by weight: 10-15 parts of wormwood, 2-5 parts of pseudo-ginseng, 5-10 parts of ligusticum wallichii, 5-10 parts of salvia miltiorrhiza, 10-15 parts of garden balsam stem and 5-10 parts of rhizoma acori graminei.
4. The massage oil for relieving pain as claimed in claim 1, wherein the essential oil composition is one or more of helichrysum essential oil, peppermint essential oil, perilla essential oil, marjoram essential oil, clove essential oil, black pepper essential oil, mandarin essential oil, sandalwood essential oil, bergamot essential oil, chamomile essential oil, orange flower essential oil, ylang essential oil, star anise essential oil, almond kernel oil, sweet almond oil, glycerin, avocado oil, babassu oil, grape seed oil, macadamia nut oil.
5. The massage oil for relieving pain as claimed in claim 4, wherein the essential oil composition is a compound of star anise essential oil, ylang essential oil, babassu oil and macadamia nut oil, and the mass ratio of the essential oil composition to the compound is 0.7-0.9:0.3-0.5:18-25:22-31.
6. The massage oil for relieving pain as claimed in claim 1, wherein the moisturizer is one or a combination of ginseng root extract, algae extract, phytosterol, glycine, hydrolyzed wheat protein, arginine, theanine and hydroxyproline.
7. The massage oil for relieving pain of claim 6, wherein the moisturizing agent is a compound of hydrolyzed wheat protein, hydroxyproline and arginine, and the mass ratio of the moisturizing agent to the amino acid is 1.2-1.4:0.2-0.5:0.3-0.5.
8. The massage oil for relieving pain as claimed in claim 1, wherein the additive is one or a combination of forsythia extract, perilla leaf extract, garlic extract pectin, mannan, and tea leaf extract.
9. The massage oil for relieving pain as claimed in claim 2, 3 or 5, wherein the additive is a combination of perilla leaf extract and tea leaf extract, and the mass ratio of the additive to the tea leaf extract is 0.3-0.5:0.7-0.9.
10. A method for preparing a massage oil for relieving pain according to any one of claims 1 to 9, comprising the steps of:
(1) The preparation method of the traditional Chinese medicine extract comprises the following steps: weighing 37-65 parts of traditional Chinese medicine extract, placing in a heating reflux device, adding a solvent, heating and refluxing at the temperature of 60-70 ℃ for 3-4 h, filtering to obtain a traditional Chinese medicine extract, and drying the traditional Chinese medicine extract in a dryer at the temperature of 50-60 ℃ for 2-2.5 h;
(2) Adding the essential oil composition and the traditional Chinese medicine extract into a reaction kettle, and uniformly stirring at 50-55 ℃ for 15-20 min to fully homogenize and mix the essential oil composition and the traditional Chinese medicine extract to obtain a mixture a for later use;
(3) Adding the humectant and the additive into the mixture a in the reaction kettle in the step (2), stirring, heating and mixing at the stirring temperature of 80-85 ℃ for 20-30 min, cooling the reaction kettle to 25-30 ℃ to prepare a mixture b, taking out the mixture b in the reaction kettle, and performing sterilization treatment to prepare the massage oil for relieving pain.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202111437448.6A CN115463185A (en) | 2021-11-29 | 2021-11-29 | Massage oil for relieving pain and preparation method thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202111437448.6A CN115463185A (en) | 2021-11-29 | 2021-11-29 | Massage oil for relieving pain and preparation method thereof |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN115463185A true CN115463185A (en) | 2022-12-13 |
Family
ID=84364804
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN202111437448.6A Pending CN115463185A (en) | 2021-11-29 | 2021-11-29 | Massage oil for relieving pain and preparation method thereof |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN115463185A (en) |
Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102988463A (en) * | 2012-12-27 | 2013-03-27 | 马培洪 | Fumigation medicament for treating cervical spondylosis |
| CN107334823A (en) * | 2017-05-31 | 2017-11-10 | 赵健 | One kind analgesic eliminating impediment essential oil and preparation method thereof |
| CN109260322A (en) * | 2018-09-27 | 2019-01-25 | 郭心畅 | Plants essential oil |
| CN112472661A (en) * | 2020-12-11 | 2021-03-12 | 云南苏旺润生物医药有限公司 | Cannabidiol massage oil composition and preparation method and application thereof |
| CN113230331A (en) * | 2021-05-30 | 2021-08-10 | 李立义 | Massage oil for relieving wandering pain and preparation method thereof |
-
2021
- 2021-11-29 CN CN202111437448.6A patent/CN115463185A/en active Pending
Patent Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102988463A (en) * | 2012-12-27 | 2013-03-27 | 马培洪 | Fumigation medicament for treating cervical spondylosis |
| CN107334823A (en) * | 2017-05-31 | 2017-11-10 | 赵健 | One kind analgesic eliminating impediment essential oil and preparation method thereof |
| CN109260322A (en) * | 2018-09-27 | 2019-01-25 | 郭心畅 | Plants essential oil |
| CN112472661A (en) * | 2020-12-11 | 2021-03-12 | 云南苏旺润生物医药有限公司 | Cannabidiol massage oil composition and preparation method and application thereof |
| CN113230331A (en) * | 2021-05-30 | 2021-08-10 | 李立义 | Massage oil for relieving wandering pain and preparation method thereof |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN107737041A (en) | A kind of novel skin antiallergic maintenance composition, skin repair frost and preparation method thereof | |
| CN103479775B (en) | Scraping liniment and preparation method thereof | |
| CN107536774B (en) | Traditional Chinese medicine hair blackening and moistening agent and preparation method thereof | |
| CN110314226A (en) | Whitening spot-removing, topical agent of anti-acne and preparation method thereof | |
| CN109364207A (en) | A kind of composition and preparation method and the application for the treatment of and alleviation acne | |
| CN111110617A (en) | Skin care product prepared from Chinese medicinal extract and its preparation method | |
| CN106074778B (en) | Traditional Chinese medicine composition for treating leucoderma and preparation thereof | |
| CN115463185A (en) | Massage oil for relieving pain and preparation method thereof | |
| CN105748374A (en) | Traditional Chinese medicine toner with effect of tendering and caring skin | |
| CN111840416A (en) | Marrow-washing bone-setting liquid | |
| CN102085241A (en) | Chinese medicinal composition for fumigation treatment of skin diseases | |
| CN110559418B (en) | Traditional Chinese medicine composition with alopecia prevention effect and extract and application thereof | |
| CN108567831B (en) | Traditional Chinese medicine patch, preparation method and application thereof | |
| CN112294891A (en) | Externally-applied traditional Chinese medicine composition for treating allergic rhinitis and preparation method and application thereof | |
| CN111202835A (en) | Vinasse traditional Chinese medicine bag for treating rheumatic arthralgia, lumbar muscle strain and joint injury | |
| CN110856708A (en) | Facial mask liquid and preparation method thereof | |
| CN114469845B (en) | External preparation using wasp needle liquid and preparation method thereof | |
| CN115463205A (en) | Traditional Chinese medicine composition with hair blackening, hair growing and hair caring effects, traditional Chinese medicine preparation, and preparation method and application thereof | |
| CN110403988B (en) | A Chinese medicinal ointment with effects of promoting blood circulation and removing blood stasis, and its preparation method | |
| CN108686092A (en) | Eliminate the Chinese medicinal aqua and preparation method thereof of scar | |
| CN114788854B (en) | Traditional Chinese medicine composition and preparation method and application thereof | |
| CN115779021B (en) | Snake medicinal oil for radiotherapy protection and preparation method thereof | |
| CN116327866B (en) | She mud moxibustion wind-damp-dispelling physiotherapy prescription technology | |
| CN114762719B (en) | Traditional Chinese medicine composition for relaxing tendons and activating collaterals and preparation method thereof | |
| CN106692746A (en) | Externally used energy oil for improving hypomenorrhea and light menses, and preparation method thereof |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PB01 | Publication | ||
| PB01 | Publication | ||
| SE01 | Entry into force of request for substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| RJ01 | Rejection of invention patent application after publication |
Application publication date: 20221213 |
|
| RJ01 | Rejection of invention patent application after publication |