CN115461081A - 美容用微针阵列 - Google Patents
美容用微针阵列 Download PDFInfo
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- CN115461081A CN115461081A CN202180031977.8A CN202180031977A CN115461081A CN 115461081 A CN115461081 A CN 115461081A CN 202180031977 A CN202180031977 A CN 202180031977A CN 115461081 A CN115461081 A CN 115461081A
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- Prior art keywords
- microneedle
- fat
- agent
- acid
- formulation
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Abstract
本发明提供一种具有脂肪溶解作用的有价物质的新的施用方法。提供含有脂肪分解剂、脂肪溶解剂或脂肪代谢促进剂的任意1种以上、以脂肪减少和/或局部瘦身和/或皮肤拉紧为目的的微针制剂、以及包含以水溶性高分子作为基剂、并含有选自脂酶、磷脂酰胆碱及脱氧胆酸中的1种以上的微针阵列的微针制剂。
Description
技术领域
本发明涉及一种以分解、溶解皮下的脂肪为目的的微针阵列。具体而言,涉及含有属于有价成分的脂肪溶解剂等作为主成分的微针的技术领域。
背景技术
脂肪的皮下蓄积与脂肪细胞的功能障碍有关联,所蓄积的甘油三酯在酶作用下被分解,并被再分解为脂肪酸、甘油和/或甘油酯。基于各种理由,在脂肪细胞中发生甘油三酯的蓄积,产生脂肪的皮下蓄积。其结果是体重过重,成为治疗上、美容上的问题。
对于该皮下的脂肪蓄积、肥胖中的呈现出过度的脂肪层的肥胖,采取将除去脂肪的皮下蓄积的组合物直接向皮下注入的方法。其中,使用以Sanofi公司(Sanofi-Aventis)的保脂妥(Lipostabil)为代表的磷脂酰胆碱制剂(专利文献1、2)。另一方面,还已知有脱氧胆酸的皮下注射。但是,存在有手术时的疼痛、皮肤肿胀等从安全性的方面考虑被视为问题的状况,可以说是风险高的方法。另外,在注射的情况下,必须对一定面积将注射针在皮下摆动地注入。此外,因注入的液体的不均而使脂肪溶解的情况变动,产生皮肤的凹凸。
现有技术文献
专利文献
专利文献1:日本特表2007-509085号公报
专利文献2:日本特表2007-515439号公报
发明内容
发明所要解决的课题
本发明的目的在于,提供具有脂肪溶解作用的有价物质的新的施用方法。
用于解决课题的手段
微针贯穿妨碍脂肪溶解剂的吸收的角质层,可以期待易于将脂肪溶解剂向皮下组织扩散的效果。特别是溶解肥胖部位的皮下脂肪,实现局部瘦身、眼袋的减少、小脸线条。另外,能够期待通过溶解松弛部分的皮下脂肪而带来的拉紧效果。微针贴片与注射不同,能够实现1次粘贴中的大面积的护理。由于目前为止完全不存在以脂肪溶解为目的的微针制剂,因此完全没有关于将上述的有价物质微针化时的有价物质的浓度、皮肤应用的频度等的见解,如何操作来确保有价物质的组合、制剂的稳定性及皮肤移行性成为重要课题。本发明人等成功地解决了此种课题,制造出含有具有脂肪溶解作用的有价物质的微针制剂,从而完成了本发明。
本发明如下所示。
〔1〕一种微针制剂,其含有脂肪分解剂、脂肪溶解剂或脂肪代谢促进剂的任意1种以上,以脂肪减少和/或局部瘦身和/或皮肤拉紧为目的。
〔2〕一种微针制剂,其含有0.1质量%以上的选自脂肪分解剂、脂肪溶解剂及脂肪代谢促进剂中的1种以上的对于脂肪减少发挥作用的成分,且以脂肪减少和/或局部瘦身和/或皮肤拉紧为目的。
〔3〕根据〔1〕或〔2〕中记载的微针制剂,其中,脂肪分解剂为脂酶。
〔4〕根据〔3〕中记载的微针制剂,其中,含有脂酶与Mg盐及Ca盐。
〔5〕根据〔1〕或〔2〕中记载的微针制剂,其中,脂肪溶解剂为选自磷脂酰胆碱、三磷酸腺苷及其钠盐以及脱氧胆酸中的1种以上。
〔6〕根据〔1〕或〔2〕中记载的微针制剂,其中,脂肪代谢促进剂为选自氨基酸、左旋肉碱、肌醇、辣椒素及咖啡因中的1种以上。
〔7〕根据〔6〕中记载的微针制剂,其中,氨基酸为选自酪氨酸、丝氨酸、苏氨酸、苯丙氨酸、色氨酸、异亮氨酸、赖氨酸、精氨酸、甜菜碱、组氨酸、谷氨酸、甘氨酸及半胱氨酸中的1种以上。
〔8〕根据〔1〕~〔7〕中任一项记载的微针制剂,其为针长度50~350μm且插入到表皮的微针制剂。
〔9〕根据〔1〕~〔7〕中任一项记载的微针制剂,其为针长度351~1000μm且插入到真皮的微针制剂。
〔10〕根据〔1〕~〔9〕中任一项记载的微针制剂,其包含以水溶性高分子作为基剂、并含有选自脂酶、磷脂酰胆碱及脱氧胆酸中的1种以上的微针阵列。
〔11〕根据〔1〕~〔9〕中任一项记载的微针制剂,其包含以水溶性高分子作为基剂、并含有选自脂酶、磷脂酰胆碱、脱氧胆酸、酪氨酸、左旋肉碱及咖啡因中的1种以上的微针阵列。
〔12〕根据〔1〕~〔11〕中任一项记载的微针制剂,其中,脂肪溶解剂包含磷脂酰胆碱及脱氧胆酸的组合。
〔13〕根据〔1〕~〔12〕中任一项记载的微针制剂,其中,还含有酶发酵植物提取物。
〔14〕根据〔1〕~〔13〕中任一项记载的微针制剂,其中,在微针的与针林立的面相反一侧的面具有在一面具有粘合层的支承体膜。
〔15〕根据〔14〕中记载的微针制剂,其中,上述微针制剂包含溶解型微针阵列,上述粘合层以与该微针阵列中的浓度相同或在其以下的浓度含有与该溶解型微针阵列中含有的脂肪分解剂、脂肪溶解剂或脂肪代谢促进剂相同的成分。
〔16〕根据〔1〕~〔15〕中任一项记载的微针制剂,其为眼袋缩小用。
发明效果
根据本发明,能够容易并且均匀地溶解皮下脂肪。
附图说明
图1是表示本发明的微针阵列的制造方法的一例的剖视图。
图2A是试验例2的使用前的眼睑下部的照片。
图2B是试验例2的使用后的眼睑下部的照片。
图3是表示试验例3的皮下脂肪的厚度的变化的曲线图。
具体实施方式
微针制剂(微针阵列)
是包含在厚度10~200μm的基板上林立着高度50~1000μm的圆锥形火山状或金字塔状、针状的微针的微针阵列的制剂。
在将微针制剂插入到表皮的情况下,针长度优选为50~350μm。
在将微针制剂插入到真皮的情况下,针长度优选为351~1000μm。
微针在基剂中溶解或以悬浮状态分散着有价物质。或者,也可以将有价物质涂布于针前端。
本发明的微针制剂中,作为有价物质含有脂肪分解剂、脂肪溶解剂或脂肪代谢促进剂的任意1种以上。有价物质是对于脂肪减少发挥作用的成分,在微针制剂中含有0.1质量%以上。本发明的微针制剂可以出于脂肪减少和/或局部瘦身和/或皮肤拉紧的目的合适地使用。对于有价物质的含量,为了促进皮下脂肪的分解、溶解或代谢,优选为0.1~100质量%,更优选为0.2~80质量%。此外每平方厘米的有价物质的量优选为1μg~1000mg。
通过在微针阵列中在具有脂肪分解、溶解、脂肪代谢促进作用的有价物质的基础上,还并用脂肪燃烧的促进成分、促进从脂肪细胞中的脂肪分解排出的成分、皮肤拉紧成分等,可以提高脂肪分解、溶解效果。
作为脂肪分解剂,有脂酶之类的脂肪分解酶、胰高血糖素、肾上腺素、去甲肾上腺素、饥饿素、生长激素、睾酮、皮质醇之类的激素。另外,与护理部位及目的匹配地并用作为蛋白质分解酶的蛋白酶、作为胶原蛋白分解酶的胶原蛋白酶、作为透明质酸分解酶的透明质酸酶、以及从蔬菜、水果、海藻中发酵提取的酶发酵植物提取物等也是有效的。
脂肪分解剂优选为脂酶。在使用脂酶的情况下,可以共存脂酶的稳定化剂。例如,可以举出甘油、甘氨酸、巯基乙醇、Triton X-100、Triton N-101、脱氧胆酸、Mg2+离子、Ca2+离子、BSA、盐类等。Mg2+离子及Ca2+离子可以以盐的形式共存。
作为脂肪溶解剂,可以举出磷脂酰胆碱、黑角藻提取物、酪氨酸、三磷酸腺苷及其钠盐、欧洲七叶树提取物、核桃、甲基丙二醇、甘露糖醛酸甲基硅醇、翁草提取物、蓝堇、脱氧胆酸、鹅脱氧胆酸等。此外还可以举出黄嘌呤衍生物(咖啡因、茶碱、可可碱、黄嘌呤、氨茶碱、胆碱茶碱、二羟丙茶碱、羟丙茶碱及胆茶碱等)、青葛藤(木防己)提取物、洋蓟提取物、大葛藤(防己)提取物、莪术(Curcuma zedoaria)提取物、蓝堇提取物、桔梗(Platycodongrandiflorus、桔梗根)提取物、常春藤提取物、胡椒(Piper nigrum)提取物、单穗升麻根提取物、积雪草提取物、栀子果实提取物、欧烟堇(日文:フマリア·オイキナス)提取物、草莓叶提取物等。
脂肪溶解剂优选为选自磷脂酰胆碱、三磷酸腺苷及其钠盐以及脱氧胆酸中的1种以上。其中,由磷脂酰胆碱和脱氧胆酸的组合形成的脂肪溶解剂还会提高磷脂酰胆碱的稳定性,因而更加优选。
作为脂肪代谢促进剂,可以举出酪氨酸、丝氨酸、苏氨酸、苯丙氨酸、色氨酸、异亮氨酸、赖氨酸、精氨酸、甜菜碱、组氨酸、谷氨酸、甘氨酸、半胱氨酸等氨基酸、作为脂肪燃烧的促进成分的左旋肉碱、肌醇、辣椒素、咖啡因、辅酶Q10、儿茶素等。
脂肪代谢促进剂优选为选自氨基酸、左旋肉碱、肌醇、辣椒素及咖啡因中的1种以上,氨基酸也优选从上述当中使用1种以上。
对于本发明的微针阵列,就非溶解型微针而言,利用注射成型、压制成型等制造微针阵列并在针的前端涂布有价物质并使之干燥而使用。作为基剂,PGA(聚乙醇酸)、PLGA(聚乳酸-乙醇酸共聚物)、PET(聚对苯二甲酸乙二醇酯)、聚乙烯等塑料对于成型而言是便利的。
本发明中更优选溶解型微针阵列。作为基剂适合为水溶性或生物降解性高分子物质,例如为透明质酸钠、透明质酸低聚物及其衍生物、硫酸软骨素钠、羟丙基纤维素、蛋白聚糖、明胶、聚乙烯基吡咯烷酮、水解胶原蛋白、羧甲基纤维素、聚乙烯醇、葡聚糖、糊精等。使有价物质溶解于基剂中是简单明了的操作,然而也可以涂布于针前端。
上述的有价物质和基剂是本发明中的必需成分,然而并不限定其他皮肤有价物质的添加。例如,可以举出色素沉着抑制剂、保湿剂、代谢活化剂、抗氧化剂、活性氧清除剂、自由基清除剂等。
色素沉着抑制剂
本发明中可以添加色素沉着抑制剂。作为色素沉着抑制剂的具体例,可以举出对氨基苯甲酸衍生物、水杨酸衍生物、苯磺酰胺衍生物、咪唑衍生物、萘衍生物、羟基邻氨基苯甲酸或其盐以及它们的衍生物、邻氨基苯甲酸衍生物、香豆素衍生物、尿囊素衍生物、烟酸衍生物、抗坏血酸或其盐以及它们的衍生物、生育酚或其盐以及它们的衍生物、生育三烯酚或其盐以及它们的衍生物、曲酸或其衍生物、二苯酮(Oxybenzone)、二苯甲酮、愈创奥、紫草素、黄芩苷或其盐以及它们的衍生物、黄芩素或其盐以及它们的衍生物、小檗碱或其盐以及它们的衍生物、芹菜素或其盐以及它们的衍生物、木犀草素或其盐以及它们的衍生物、山奈酚或其盐以及它们的衍生物、槲皮素或其盐以及它们的衍生物、槲皮苷或其盐以及它们的衍生物、异槲皮苷或其盐以及它们的衍生物、芦丁或其盐以及它们的衍生物、杨梅黄酮或其盐以及它们的衍生物、柚皮素或其盐以及它们的衍生物、橙皮苷或其盐以及它们的衍生物、谷胱甘肽或其盐以及它们的衍生物、鞣花酸或其盐以及它们的衍生物等。
保湿剂
在本发明中可以添加保湿剂。作为保湿剂的具体例,可以举出榅桲籽、琼脂或其衍生物、酪蛋白、葡萄糖、半乳糖、甘露糖、木糖、果糖、麦芽糖、异麦芽糖、纤维二糖、龙胆二糖、海藻糖、Pillarose(日文:ピラロ一ス)、1,3-丁二醇、甘油、丙二醇、聚乙二醇、二丙二醇、1,2-戊二醇、1,5-戊二醇、1,2-己二醇、1,6-己二醇、甘露醇及山梨醇、1,2-丙二醇、1,3-丙二醇、聚丙二醇、1,2-丁二醇、1,3-丁二醇、1,4-丁二醇、戊二醇、己二醇、1,3-戊二醇、1,4-戊二醇、赤藓醇、季戊四醇、二季戊四醇、木糖醇、麦芽糖醇、肌醇、泛醇或其衍生物、糊精、明胶、果胶、淀粉、角叉菜胶、羧甲基甲壳素或壳聚糖、壳聚糖盐、硫酸化甲壳素或壳聚糖、磷酸化甲壳素或壳聚糖、海藻酸或其盐、透明质酸或其盐、硫酸软骨素或其盐、β-1,3-葡聚糖、β-1,4-葡聚糖、β-1,6-葡聚糖、葡萄糖胺、肝素、乙基纤维素、甲基纤维素、羧甲基纤维素、羧乙基纤维素、羧乙基纤维素钠、羟乙基纤维素、羟丙基纤维素、硝基纤维素、晶体纤维素、羟丙基甲基纤维素、聚乙烯醇、聚乙烯基甲基醚、聚乙烯基吡咯烷酮、聚丙烯酸盐、羧基乙烯基聚合物、硫酸皮肤素、硫酸角质素等水溶性高分子类、吡咯烷酮羧酸或其盐、聚谷氨酸或其盐、天然保湿因子中含有的吡咯烷酮羧酸、尿素、尿刊酸、甜菜碱、乳酸钠、天冬氨酸、谷氨酸、异亮氨酸、组氨酸、苯丙氨酸、苏氨酸、丝氨酸、缬氨酸、脯氨酸、甘氨酸、丙氨酸、赖氨酸、精氨酸、神经酰胺1、神经酰胺2、神经酰胺3、神经酰胺4、神经酰胺5、神经酰胺6II、神经酰胺9等神经酰胺类等。
代谢活化剂
本发明中可以添加代谢活化剂。作为代谢活化剂的具体例,可以举出维生素A组:视黄醇或其盐以及它们的衍生物、视黄醛或其盐以及它们的衍生物、脱氢视黄醛或其盐以及它们的衍生物、视黄酸或其盐以及它们的衍生物、胡萝卜素或其盐以及它们的衍生物、番茄红素或其盐以及它们的衍生物、
维生素B组:硫胺素或其盐以及它们的衍生物、核黄素或其盐以及它们的衍生物、吡哆醇或其盐以及它们的衍生物、吡哆醛或其盐以及它们的衍生物、氰钴胺或其盐以及它们的衍生物、叶酸或其盐以及它们的衍生物、烟酸或其盐以及它们的衍生物、泛酸或其盐以及它们的衍生物、生物素或其盐以及它们的衍生物、胆碱或其盐以及它们的衍生物、肌醇或其盐以及它们的衍生物、
维生素C组:抗坏血酸或其盐以及它们的衍生物、
维生素D组:麦角钙化醇或其盐以及它们的衍生物、胆钙化醇及其盐以及它们的衍生物、
维生素E组等:生育酚或其盐以及它们的衍生物、生育三烯酚或其盐以及它们的衍生物、泛醌或其盐以及它们的衍生物、亚油酸或其盐以及它们的衍生物、亚麻酸或其盐以及它们的衍生物、花生四烯酸或其盐以及它们的衍生物等、肉毒碱或其盐以及它们的衍生物、阿魏酸或其盐以及它们的衍生物、γ-谷维素或其盐以及它们的衍生物、
维生素P组:芦丁或其盐以及它们的衍生物、橙皮苷或其盐以及它们的衍生物、氨基酸类及其他:缬氨酸、亮氨酸、异亮氨酸、苏氨酸、蛋氨酸、苯丙氨酸、色氨酸、赖氨酸、甘氨酸、丙氨酸、天冬氨酸、谷氨酸、丝氨酸、半胱氨酸、胱氨酸、酪氨酸、脯氨酸、羟基脯氨酸、天冬氨酸、谷氨酸、羟基赖氨酸、精氨酸、鸟氨酸、组氨酸或其衍生物等、它们的硫酸盐、磷酸盐、硝酸盐、柠檬酸盐、或吡咯烷酮羧酸等氨基酸衍生物等氨基酸类、乙醇酸、柠檬酸、苹果酸、酒石酸、乳酸、琥珀酸等α-羟基酸类、2-羟基羧酸类、多羟基羧酸或羟基多羧酸类、乳糖酸、感光素301号、桧木醇、泛酸或其衍生物、尿囊素、三甲基甘氨酸、蛋白聚糖等。
抗氧化剂
本发明中可以添加抗氧化剂。作为抗氧化剂的具体例,可以举出抗坏血酸或其盐以及它们的衍生物、生育酚或其盐以及它们的衍生物、生育三烯酚或其盐以及它们的衍生物、丁基羟基甲苯(BHT)、丁基羟基茴香醚(BHA)、辅酶Qn(n=7~10)、吡咯并喹啉醌、没食子酸丙酯、芝麻酚、类胡萝卜素类等。
活性氧清除剂、自由基清除剂
本发明中可以添加活性氧清除剂、自由基清除剂。作为活性氧清除剂、自由基清除剂的具体例,可以举出超氧化物歧化酶、过氧化氢酶、谷胱甘肽过氧化物酶、胆红素、槲皮素、槲皮苷、儿茶素、儿茶素衍生物、芦丁或其衍生物、没食子酸或其盐以及它们的衍生物、姜黄素或其盐以及它们的衍生物、转铁蛋白、铜蓝蛋白、辅酶Qn(n=7~10)、尿酸、胆红素、金属硫蛋白等。
本发明中可以在上述的构成成分以外还添加通常在化妆品、医药品等皮肤外用剂中使用的成分。包含选自水性成分、油性成分、植物提取物、动物提取物、粉末、表面活性剂、油剂、醇、pH调节剂、防腐剂、增稠剂、色素、香料等中的1种以上的成分,它们是基剂的一部分,并且由于其对于皮肤的效果(例如皮肤拉紧作用),也可以作为有价物质发挥作用。
本发明的微针阵列的制造方法没有特别限定,只要利用以往公知的任意的方法制造即可,例如可以举出如下的方法,即,在穿设有微针的形状的模具中,流延在包含上述水溶性高分子物质的基剂的水溶液或悬浮液中溶解或悬浮有价物质、并根据需要加入了其他的成分的原料水溶液,干燥后进行剥离。剥离后,裁割为贴片的形状,也可以利用粘合性支承体进行加衬。
上述为溶解型微针阵列的制法。本发明的微针阵列不仅在溶解型微针阵列中有效,在涂布型微针阵列中也有效。涂布型微针阵列的制法为,预先利用注射成型、压制成型等制成微针阵列,在其针尖涂布有价物质及基剂的混合物并使之干燥。
由微针阵列形成的贴片(微针贴片)的大小为0.5~300cm2。若小于0.5cm2,则效果受到限定,难以发挥有效性。若大于300cm2,则易于在覆盖身体表面时在密合性方面产生问题。在覆盖大的身体表面时,只要使用多个300cm2以下的微针贴片即可。针长度适合为50~1000μm。使50~350μm的微针作用于表皮。该长度以上的长度的微针还会作用于真皮。
为了将微针贴片稳定地应用于皮肤并保持于皮肤,虽然并非必须,然而更优选在贴片的背面具有粘合性支承体。此处,所谓“背面”,是指微针的与林立着针的面相反一侧的面。粘合性支承体是在一面具有粘合层的支承体膜。
作为本发明的粘合层,可以使用包含市售的粘合剂的粘合性片。可以使用橡胶系粘合剂、硅酮系粘合剂等,然而若考虑与皮肤的密合性和向支承体膜的附着性,则优选丙烯酸系粘合剂。具体而言,为丙烯酸烷基酯的共聚物以及以丙烯酸烷基酯为主的与丙烯酸、丙烯酰胺、乙酸乙烯酯等的共聚物。在这些粘合剂中为了改善皮肤粘合性可以添加肉豆蔻酸异丙酯或棕榈酸异丙酯之类的增塑剂。粘合层的厚度期望为10μm以上且300μm以下。具体而言,可以合适地使用HiPAS(注册商标)粘合剂(丙烯酸酯、考司美德制药(株)制)、MASCOS10(商品名)粘合剂(丙烯酸酯、考司美德制药(株)制)。
本发明的作为有价物质的脂肪溶解剂多使用低分子化合物,该情况下,即使在微针中含有,在长期保存期间脂肪溶解剂也会在粘合层中扩散,其结果是有微针中的脂肪溶解剂含量减少的情况。同样的现象也适用于所使用的脂肪分解剂及脂肪代谢促进剂。为了防止该现象,从保存稳定性的方面出发有效的做法是,在粘合剂中也含有与浸渗于微针的有价物质相同的物质,由此来防止向粘合剂中的扩散。脂肪溶解剂、脂肪分解剂、或脂肪代谢促进剂在粘合剂中的浓度期望与在微针阵列中的浓度相同或在其以下。
将本发明的微针制剂、微针阵列、或微针贴片应用于想要除去脂肪的皮肤。应用部位为全部皮肤,没有特别限定。对于应用片数,根据想要除去脂肪的面积来设定应用片数。1次的应用时间为1秒~24小时左右,在多次应用的情况下,以0~1天的间隔应用是有效的。如下的操作也是有效的,即,将微针阵列应用于皮肤后立即从阵列背后供给水,由此使皮肤中的微针前端瞬间地溶解而促进有价物质向皮肤的吸收。此种应用尤其在美容院等中是有效的应用方法。
利用本发明,能够实现身体的所期望的部位的局部瘦身。尤其是在脸部的应用易于发挥效果。例如,在应用于眼睑下部的情况下,可以获得眼睑下部的膨胀(眼袋)的缩小效果。
实施例
以下,对本发明利用下述实施例进一步详细说明。这些实施例是单纯地用于具体说明本发明的例子,本发明的范围并不限定于这些实施例。
实施例1
微针阵列的制作
图1是表示本发明的微针阵列的制造方法的一例的剖视图。图中,1是在利用对感光性树脂进行光照射的光刻法形成圆锥形火山型的微针图案后、通过进行电铸加工而转印了圆锥形火山型的微针图案的形成有圆锥形火山型的微针形成用凹部11的铸模。2是流延于微针形成用凹部11的微针原料液。
微针形成用凹部11是根部的直径为0.6mm、尖端直径为0.02mm、深度为0.2mm的圆锥形火山型,以0.8mm间隔排列成格子状。
在室温下在水100质量份中溶解有透明质酸(Kikkoman Biochemifa制、商品名“FCH-SU”)4质量份和脂酶(和光纯药制、商品名“Lipase AK Amano”)0.1质量份的水溶液中添加溶解于乙醇+甘油中的磷脂酰胆碱(和光纯药)和脱氧胆酸(和光纯药),分别达到0.2质量份和0.8质量份,将所得的水溶液(微针原料液)流延在铸模1上,使水溶液中的水分蒸发后,从铸模1剥离并冲裁为椭圆形(10×50mm、短径×长径)。
带有保护粘合带的微针阵列的制作
将椭圆形的微针阵列(10×50mm、短径×长径)安放在做成圆角的长方形(16×60mm)的带有支承体的粘合带的中央部,由此得到本发明的带有保护粘合带的微针阵列。
试验例1体外(In vitro)试验
在纵横2cm厚度1cm的牛油的上表面平面中央部,密合实施例1中制作的无支承体的微针阵列。从滴管向微针阵列中央部滴下40mg的水,促进微针阵列的溶解。观察在室温放置20小时后的牛油上表面。滴下了水的中央部凹陷成透镜状,凹坑的深度在最深部约为1mm。本现象是因为,因配合在微针中的油脂分解、溶解成分而生成牛油的分解成分,或者因与溶解成分的相互作用而生成牛油可溶成分,这些生成物在牛油内扩散到内部,其结果是,产生透镜状的凹坑。
比较试验例1
除了在试验例1中所密合的微针阵列仅由透明质酸形成以外,实施完全同样的试验。室温20小时后牛油上表面完全没有变化。
试验例2体内(In vivo)试验
在成人男性志愿者的右眼睑下部,在就寝前粘贴除了不含有脂酶以外利用与实施例1同样的方法制作的微针阵列,第二天早上剥下。实施4天(共计4次)的进行同样的粘贴的试验。在左眼睑下部没有进行任何粘贴。将试验前后的眼睑下部的照片表示于图2A及图2B中。显而易见,与左眼睑下部相比,右眼睑下部的膨胀(眼袋)缩小。
实施例2
试验用微针阵列及保护粘合带的制作
利用与实施例1同样的方法制作出微针阵列。阵列的主要组成为,相对于微针阵列的质量100质量份,透明质酸为72质量份,磷脂酰胆碱为5质量份,脱氧胆酸钠为15质量份,水解胶原蛋白为5质量份。将制作出的微针阵列与实施例1同样地冲裁为椭圆形后用于试验。
在带有支承体的粘合带中使用橡胶系作为粘合剂,为了防止磷脂酰胆碱及脱氧胆酸钠从阵列向粘合剂的迁移,在粘合剂中也含有磷脂酰胆碱及脱氧胆酸钠。具体而言,粘合剂(100质量份)在包含苯乙烯-异戊二烯树脂、增粘树脂以及油的基本组合物中,含有磷脂酰胆碱及脱氧胆酸钠各1质量份。与实施例1同样地得到的带有保护粘合带的微针阵列为与实施例1同样的形状。
试验例3
在成人女性志愿者3名的脸颊部,在就寝前粘贴实施例2的带有保护粘合带的微针阵列,第二天早上剥下。实施2周进行3次/周的同样的粘贴的试验,评价本微针阵列的有效性。使用皮下脂肪厚度计SR-803((株)Tanita)测定出试验前后的微针阵列粘贴部位的皮下脂肪厚度。将结果表示于表1及图3中。皮下脂肪厚度的测定原理如下所示。即,脂肪基本上不导电,然而肌肉、皮内水分为导电性的,从而是通过测定脸颊部的导电性来评价皮下脂肪的厚度的方法。表1及图3中,以使用前的皮下脂肪厚度为100,表示出使用后的值。显而易见,利用本微针阵列的粘贴,脸颊部皮下脂肪减少。
[表1]
脸颊的皮下脂肪厚度的变化
如以上的有效性试验所示,本微针阵列对于皮下脂肪的减少显示出定量的效果。具有此种效能的微针及其他粘贴剂此前为止完全不存在。
附图标记说明
1 铸模,2 微针原料液,11 微针形成用凹部。
Claims (16)
1.一种微针制剂,其含有脂肪分解剂、脂肪溶解剂或脂肪代谢促进剂的任意1种以上,且以脂肪减少和/或局部瘦身和/或皮肤拉紧为目的。
2.一种微针制剂,其含有0.1质量%以上的选自脂肪分解剂、脂肪溶解剂及脂肪代谢促进剂中的1种以上的对于脂肪减少发挥作用的成分,且以脂肪减少和/或局部瘦身和/或皮肤拉紧为目的。
3.根据权利要求1或2所述的微针制剂,其中,
脂肪分解剂为脂酶。
4.根据权利要求3所述的微针制剂,其中,
含有脂酶与Mg盐及Ca盐。
5.根据权利要求1或2所述的微针制剂,其中,
脂肪溶解剂为选自磷脂酰胆碱、三磷酸腺苷及其钠盐以及脱氧胆酸中的1种以上。
6.根据权利要求1或2所述的微针制剂,其中,
脂肪代谢促进剂为选自氨基酸、左旋肉碱、肌醇、辣椒素及咖啡因中的1种以上。
7.根据权利要求6所述的微针制剂,其中,
氨基酸为选自酪氨酸、丝氨酸、苏氨酸、苯丙氨酸、色氨酸、异亮氨酸、赖氨酸、精氨酸、甜菜碱、组氨酸、谷氨酸、甘氨酸及半胱氨酸中的1种以上。
8.根据权利要求1~7中任一项所述的微针制剂,其为针长度50μm~350μm且插入到表皮的微针制剂。
9.根据权利要求1~7中任一项所述的微针制剂,其为针长度351μm~1000μm且插入到真皮的微针制剂。
10.根据权利要求1~9中任一项所述的微针制剂,其包含以水溶性高分子作为基剂、并含有选自脂酶、磷脂酰胆碱及脱氧胆酸中的1种以上的微针阵列。
11.根据权利要求1~9中任一项所述的微针制剂,其包含以水溶性高分子作为基剂、并含有选自脂酶、磷脂酰胆碱、脱氧胆酸、酪氨酸、左旋肉碱及咖啡因中的1种以上的微针阵列。
12.根据权利要求1~11中任一项所述的微针制剂,其中,
脂肪溶解剂包含磷脂酰胆碱及脱氧胆酸的组合。
13.根据权利要求1~12中任一项所述的微针制剂,其中,
还含有酶发酵植物提取物。
14.根据权利要求1~13中任一项所述的微针制剂,其中,
在微针的与林立着针的面相反一侧的面具有在一面具有粘合层的支承体膜。
15.根据权利要求14所述的微针制剂,其中,
所述微针制剂包含溶解型微针阵列,
所述粘合层以与所述微针阵列中的浓度相同或在其以下的浓度含有与所述溶解型微针阵列中含有的脂肪分解剂、脂肪溶解剂或脂肪代谢促进剂相同的成分。
16.根据权利要求1~15中任一项所述的微针制剂,其为眼袋缩小用。
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Citations (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2014003002A1 (ja) * | 2012-06-27 | 2014-01-03 | コスメディ製薬株式会社 | マイクロニードルパッチの保護離型シート |
KR101806074B1 (ko) * | 2017-05-26 | 2017-12-07 | 유승민 | 지방분해용 조성물 |
CN109568567A (zh) * | 2019-01-15 | 2019-04-05 | 武汉德丽福生物科技有限公司 | 一种微针减肥贴片及其制备方法 |
CN110302082A (zh) * | 2018-03-27 | 2019-10-08 | 上海同柏生物科技有限公司 | 用于减少身体脂肪沉积的技术及组合物制剂与应用 |
CN110974891A (zh) * | 2019-12-23 | 2020-04-10 | 广州新济薇娜生物科技有限公司 | 用于减肥的微针贴片及其制备方法 |
Family Cites Families (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE10349979B4 (de) | 2003-10-24 | 2006-05-18 | Sanofi-Aventis Deutschland Gmbh | Medikamentöse gezielte lokale Lipolyse |
DE10361067A1 (de) | 2003-12-22 | 2005-07-14 | Aventis Pharma Deutschland Gmbh | Medikamentöse Lipolyse von Fettansammlungen |
EP2485738A4 (en) * | 2009-10-09 | 2015-04-01 | Atheronova Operations Inc | COMPOSITIONS AND METHOD FOR THE TREATMENT OF ADIPOSITAS |
-
2021
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- 2021-05-28 JP JP2021090218A patent/JP2021186680A/ja active Pending
- 2021-05-28 AU AU2021283320A patent/AU2021283320A1/en active Pending
- 2021-05-28 CA CA3180442A patent/CA3180442A1/en active Pending
- 2021-05-28 CN CN202180031977.8A patent/CN115461081A/zh active Pending
- 2021-05-28 WO PCT/JP2021/020330 patent/WO2021246301A1/ja unknown
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Patent Citations (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2014003002A1 (ja) * | 2012-06-27 | 2014-01-03 | コスメディ製薬株式会社 | マイクロニードルパッチの保護離型シート |
KR101806074B1 (ko) * | 2017-05-26 | 2017-12-07 | 유승민 | 지방분해용 조성물 |
CN110302082A (zh) * | 2018-03-27 | 2019-10-08 | 上海同柏生物科技有限公司 | 用于减少身体脂肪沉积的技术及组合物制剂与应用 |
CN109568567A (zh) * | 2019-01-15 | 2019-04-05 | 武汉德丽福生物科技有限公司 | 一种微针减肥贴片及其制备方法 |
CN110974891A (zh) * | 2019-12-23 | 2020-04-10 | 广州新济薇娜生物科技有限公司 | 用于减肥的微针贴片及其制备方法 |
Non-Patent Citations (3)
Title |
---|
ANITA DANGOL等: "Anti-obesity effect of a novel caffeine-loaded dissolving microneedle patch in high-fat diet-induced obese C57BL/6J mice", 《JOURNAL OF CONTROLLED RELEASE》, vol. 265, pages 41 - 47, XP085302575, DOI: 10.1016/j.jconrel.2017.03.400 * |
SUNG-MIN AN等: "Intracutaneous delivery of gelatins induces lipolysis and suppresses lipogenesis of adipocytes", 《ACTA BIOMATERIALI》, vol. 67, pages 238, XP085385454, DOI: 10.1016/j.actbio.2017.11.050 * |
孟胜男等: "《药剂学》", vol. 1, 上海科学技术出版社, pages: 320 * |
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