CN115414442A - Traditional Chinese medicine preparation for treating seborrheic alopecia and preparation method thereof - Google Patents

Abstract

The invention belongs to the technical field of traditional Chinese medicine compositions, and discloses a traditional Chinese medicine preparation for treating seborrheic alopecia and a preparation method thereof, wherein the preparation method of the traditional Chinese medicine preparation for treating seborrheic alopecia comprises the following steps: mixing Poria, radix Angelicae Dahuricae, semen euryales, bombyx Batryticatus, semen Persicae, rhizoma Bletillae, herba Artemisiae Scopariae, pollen Pini, semen Camelliae sinensis, semen astragali Complanati, and Margarita powder according to corresponding weight, cleaning the above mixture, and air drying; sieving Poria, radix Angelicae Dahuricae, semen euryales, bombyx Batryticatus, semen Persicae, rhizoma Bletillae, herba Artemisiae Scopariae, pollen Pini, semen Camelliae sinensis, semen astragali Complanati, and Margarita powder; after the sieving is finished, grinding the mixture; making rice flour into blank and wrapping with rice flour to obtain wine blank; rolling a layer of fine rice flour on the wine base, putting the wine base into the yeast chamber to promote the yeast propagation in the yeast base, and storing.

Description

Traditional Chinese medicine preparation for treating seborrheic alopecia and preparation method thereof

Technical Field

The invention belongs to the technical field of traditional Chinese medicine compositions, and particularly relates to a traditional Chinese medicine preparation for treating seborrheic alopecia and a preparation method thereof.

Background

At present, seborrheic alopecia is known as premature alopecia, male alopecia, diffuse alopecia, general alopecia and the like, and the diseases are related to heredity, androgenic factors and seborrhea. The symptoms are that the grease secretion of the scalp is excessive, and the hair has greasy feeling. The clinical manifestations are that the scalp fat of the patient overflows excessively, which causes the scalp to be greasy and moist, and the dust and the scurf are mixed, so the scalp is dirty without washing the head for a few days and gives off odor, especially when the temperature is high; scalp itching and inflammation are also accompanied sometimes, and seborrheic dermatitis is mainly caused by scalp dampness and bacterial reproductive infection. Initial stage of seborrheic alopecia: the hair is oily, the hair is not washed and becomes greasy one day, the alopecia symptom is not obvious at the moment, and the hair gradually becomes thick and soft. In the middle stage: the hair is oily, and the hair is not washed and becomes greasy every day, at the moment, the alopecia symptom is obvious. The hair begins to thin and soften significantly. And (3) later stage: the oil production of the scalp is multiplied and the scalp is greasy and shiny, at which time significant areas of local alopecia, such as the crown or forehead, have occurred. The hair is slender and not long, the tail is obviously pointed, only the hair is young like cover a roof with straw hair, and the stage is the final opportunity of treatment. And (3) in the late stage: the hair on the top of the head is not fresh, the subcutaneous muscle layer disappears or is replaced by the fat layer, the scalp tissue is converted into a hairy skin area, and the hair holes become pores. It can only be called cun-fa-sheng and not cun-cao-heng. Because most people can find extremely small fine sweats at a glance by using a magnifying glass. This time, termed "permanent alopecia", the soil scalp tissue on which it lives has become thoroughly and irreversibly damaged.

Through the above analysis, the problems and defects of the prior art are as follows:

(1) The skin does not retain moisture effectively, resulting in excessive fat spillage.

(2) The hair follicle is not nourished and loses the function of hair growth for a long time.

Disclosure of Invention

Aiming at the problems in the prior art, the invention provides a traditional Chinese medicine preparation for treating seborrheic alopecia and a preparation method thereof.

The invention is realized in such a way that a preparation method of a traditional Chinese medicine preparation for treating seborrheic alopecia comprises the following steps:

step one, mixing 30g of poria cocos, 15g of radix angelicae, 30g of semen euryales, 10g of white muscardine silkworm, 10g of peach kernel, 15g of bletilla striata, 10g of oriental wormwood, 20g of pine pollen, 10g of tea seeds, 10g of flatstem milkvetch seed and 6g of pearl powder according to corresponding weight, and cleaning and airing the mixture;

sieving a mixture of 30g of poria cocos, 15g of radix angelicae, 30g of semen euryales, 10g of white muscardine silkworm, 10g of peach kernel, 15g of bletilla striata, 10g of oriental wormwood, 20g of pine pollen, 10g of tea seeds, 10g of flatstem milkvetch seed and 6g of pearl powder by utilizing a sieve;

step three, grinding the mixture after the sieving is finished;

further, in the step one, the specific process of cleaning and airing the mixture comprises:

putting the medicine mixture into a cleaning and stirring device, and stirring by using a stirring shaft;

after stirring, the drug mixture is filtered by a filtering device and dispersed and dried.

Further, in the second step, the specific process of sieving the mixture is as follows:

and putting the mixture into a sieving device, and vibrating by using a vibrating motor to realize sieving of the mixture.

Further, the sieving device is a fine sieve with 180 meshes and is stored for later use.

The invention also aims to provide a traditional Chinese medicine preparation for treating seborrheic alopecia, which is prepared by the preparation method of the traditional Chinese medicine preparation for treating seborrheic alopecia, and the traditional Chinese medicine preparation for treating seborrheic alopecia is prepared from 30g of poria cocos, 15g of radix angelicae, 30g of semen euryales, 10g of white muscardine silkworm, 10g of peach kernels, 15g of bletilla striata, 10g of oriental wormwood, 20g of pine pollen, 10g of tea seeds, 10g of flatstem milkvetch seed and 6g of pearl powder in parts by weight.

In combination with the technical solutions and the technical problems to be solved, please analyze the advantages and positive effects of the technical solutions to be protected in the present invention from the following aspects:

as inventive supplementary proof of the claims of the present invention, also present several important aspects:

(1) The expected income and commercial value after the technical scheme of the invention is converted are as follows:

the technical scheme of the invention can greatly improve the trend of the patients with the lipid alopecia to be younger, and has optimistic commercial value and social benefit.

(2) The technical scheme of the invention fills the technical blank in the industry at home and abroad:

the invention fills the domestic technical blank, reduces the secretion of grease on the head from nourishing the skin on one hand, and solves the fundamental problem of hair growth from nourishing hair follicles on the other hand, thereby curing the seborrheic alopecia.

(3) The technical scheme of the invention solves the technical problems which are always desired to be solved but are not successful:

the invention solves the fundamental problem, starts from nourishing hair follicles, and promotes healthy hair growth.

(4) The technical scheme of the invention overcomes the technical prejudice that:

the technical prejudice is overcome: treating the symptoms and not the root cause. The invention is an original method for treating both principal and secondary aspect of disease.

Drawings

Fig. 1 is a flow chart of a preparation method of a traditional Chinese medicine preparation for treating seborrheic alopecia provided by the embodiment of the invention.

Detailed Description

In order to make the objects, technical solutions and advantages of the present invention more apparent, the present invention is further described in detail with reference to the following embodiments. It should be understood that the specific embodiments described herein are merely illustrative of the invention and are not intended to limit the invention.

This section is an explanatory embodiment expanding on the claims so as to fully understand how the present invention is embodied by those skilled in the art.

The traditional Chinese medicine preparation for treating seborrheic alopecia provided by the embodiment of the invention is prepared from 30g of poria cocos, 15g of radix angelicae, 30g of semen euryales, 10g of white muscardine silkworm, 10g of peach kernel, 15g of bletilla striata, 10g of oriental wormwood, 20g of pollen pini, 10g of tea seed, 10g of flastem milkvetch seed and 6g of pearl powder in parts by weight.

Poria [ pharmacological action ]

1. Pharmacological actions related to indications

(1) The diuretic effect is influenced by animal species, administration route, etc. To human: tuckahoe → healthy people have no obvious diuretic effect and have obvious diuretic effect on patients with renal and cardiac edema. Poria cocos hormone has a structure similar to aldosterone and its antagonists → antagonizing aldosterone activity.

(2) Immunoregulation pachyman → enhancement of body immune function. Fuling → improving the nonspecific immune function of the body. But inhibit lymphocyte transformation, antibody, spleen cell antibody production ability. The mechanism is as follows: inhibit the production of IL-2.

(3) Anti-cirrhosis pachymanol → reduction of collagen content in liver and increase of output of urinary hydroxyproline → promotion of collagen degradation in liver and promotion of reabsorption of fibrous tissue in liver.

(4) Effects on gastrointestinal function: relaxing intestinal canal, and resisting ulcer.

Root of Dahurian angelica (pharmacological action)

1. Radix Angelicae Dahuricae has exciting effect on central nervous system. Small amount of angelicin has exciting effect on animal medulla oblongata blood vessel motor center, respiratory center, vagus nerve and spinal cord, and can increase blood pressure, slow pulse, deepen respiration, and cause sialorrhea and emesis; the large amount of application can cause spasticity in intermittence and then paralysis of the whole body.

2. Radix Angelicae Dahuricae has antipyretic and analgesic effects.

3. The radix Angelicae Dahuricae has antiinflammatory and antibacterial effects. The angelica dahurica decoction has certain inhibition effect on various diseases and has obvious inhibition effect on L-type tuberculosis. The radix Angelicae Dahuricae has inhibitory effect on Epidermophyton floccosum and Paecilomyces gypseum in test tube, and the water leaching agent (1:3) also has inhibitory effect on Paecilomyces oendoni.

4. Radix Angelicae Dahuricae has effect of lowering blood pressure, and isoimperatorin and quince have effect of lowering blood pressure for cat, and the action time is maintained for 1.5 hr.

5. Radix Angelicae Dahuricae has photosensitivity, and the furanocoumarin compounds such as bergapten, xanthotoxin, isoimperatorin, etc. are "photoactive substances" and can be used for treating vitiligo.

6. Radix Angelicae Dahuricae has effects of activating sympathetic system hormone and inhibiting fat synthesis.

7. Radix Angelicae Dahuricae has hemostatic effect.

8. Radix Angelicae Dahuricae has certain effect on skin. The radix angelicae tincture is externally used and irradiated by long-wave ultraviolet rays with small dose, and has obvious inhibition effect on allergic contact dermatitis of guinea pig dinitrochlorobenzene.

9. Radix Angelicae Dahuricae has effects of inhibiting liver drug metabolism enzyme system, and radix Dianthi has effect of relieving asthma.

Gorgon fruit (pharmacological action)

1. Improving renal function: the gordon euryale seed mixture (gordon euryale seed, raw astragalus, epimedium herb, honeysuckle stem, largehead atractylodes rhizome, oriental waterplantain rhizome each 12g, plantain seed 15g, coix seed 30g, tree peony bark, raw rhubarb, chinese magnoliavine fruit each 10g and liquoric root 6 g) can obviously improve the concentration of creatinine (Scr), total Cholesterol (TC), hemoglobin (Hb), high-density lipoprotein (HDL), urea nitrogen (BUN), triglyceride (TG) and albumin (Alb) of a person with chronic renal insufficiency, and has obvious difference compared with a control group. The clinical application also shows that the gordon euryale seed has obvious proteinuria eliminating effect and can obviously reduce or convert the urine protein amount of patients with chronic nephritis into negative.

2. Antioxidation: the ethanol-chloroform (2: 1), water, 80% ethanol, 95% methanol, and n-butanol extracts of semen euryales all have antioxidant activity of different degrees. The gorgon fruit polysaccharide has the function of removing hydroxyl free radicals and superoxide anions, and the action intensity is increased along with the increase of the concentration of the polysaccharide.

3. Anti-myocardial ischemia effect: the gorgon fruit water extract has the function of improving the post-ischemic heart function and reducing the damage of cardiac ischemia reperfusion is probably related to that the active component glycolipid compound of the gorgon fruit can induce the expression of TRP-32 and thioredoxin-1.

4. Anti-fatigue effect: the gorgon euryale seed polysaccharide can obviously improve the weight bearing swimming time of mice, improve the energy metabolism of organisms, accelerate the decomposition and energy supply of liver glycogen, and reduce the decomposition of protein and nitrogen-containing compounds, thereby reducing the content of blood urea nitrogen and having the anti-fatigue effect.

5. The hypoglycemic effect: the gorgon fruit shell extract plays a certain role in inhibiting the expression of gene protein tyrosine phosphatase 1B gene related to regulating blood sugar, improves the smoothness of insulin signal transduction, can also promote the improvement of the expression level of insulin receptor substrate-1 and weaken the action of insulin resistance.

6. Other functions are as follows: the semen euryales polysaccharide has inhibitory effect on Staphylococcus aureus, saccharomyces cerevisiae, bacillus subtilis and Escherichia coli. The extracts of the gordon euryale seed, the ethyl acetate and the n-butyl alcohol can play roles in delaying senility and improving learning and memory capabilities. Selenium in gorgon fruit can also resist certain chemical carcinogens.

Bombyx Batryticatus (pharmacological action)

1. Anticonvulsant action: 2g/kg of 10 percent decoction is orally taken by mice, and has obvious effect of resisting convulsion caused by the nitric acid strychnine. A mixture (WUHUAZHUIFENG powder) prepared from Bombyx Batryticatus and periostracum Cicadae can reduce the number of mice with convulsion due to strychnine, pentazocine, cocaine, and nicotine. The artificial white muscardine silkworm decoction also has the function of resisting mouse convulsion caused by strychnine.

2. Hypnotic action: the alcohol-water extract has hypnotic effect on mice and rabbits, and the mice have hypnotic effect of 0.5g/20g orally and 0.25g/20g subcutaneously, which is about equal to 50mg/kg of phenobarbital subcutaneously.

3. Pharmacological action of the stiff pupa: the effect of the stiff pupae on the convulsion of mice caused by the nitric acid strychnine is obvious, and the result is consistent with that of the white muscardine silkworm. The medical | science education web searching and arrangement is not obvious in the aspect of reducing the death rate of the test group and the control group, but the results of the stiff silkworm and the white muscardine silkworm are consistent. The stiff silkworm in the two results collected and collated by the medical | science education network is slightly superior to the stiff silkworm. In addition, the pupa bombycis can inhibit mice sarcoma-180 (further determination is needed), and has an inhibitory effect on staphylococcus aureus, escherichia coli, pseudomonas aeruginosa and the like, but the effect is not obvious. Because the pupa bombycis is convenient to obtain, it can be used to replace Bombyx Batryticatus.

4. Pharmacological research of silkworm moths: the toxicity of the silkworm moth is very low. Has promoting effect on the weight increase of immature male mice, can obviously increase the weight of prostate-seminal vesicle and glandula preputiales of castrated mice and castrated rats, and shows that the male mice have androgen-like effect.

Peach kernel [ pharmacological action ]

1. The blood vessel resistance is reduced, the haemodynamics peach kernel extract is improved, the intravenous injection can obviously increase the rabbit brain blood flow and the dog femoral artery blood flow, and the blood vessel resistance is reduced; can obviously increase the flow of perfusion liquid to the ear blood vessels of the isolated rabbit and eliminate the vasoconstriction effect of norepinephrine.

2. The antithrombotic peach kernel can obviously prolong the bleeding time and the blood coagulation time of the mouse and has the anticoagulation effect. The peach kernel decoction can obviously inhibit in-vitro thrombosis when being orally taken by cocks. Peach kernel can inhibit platelet aggregation induced by ADP, and the effect is stronger than that of Chinese angelica, red peony root, red doctor's education net collection and arrangement flower, motherwort and other medicines, and is related to the increase of cAMP content in platelets.

3. The peach kernel containing liposome for relaxing bowel contains abundant fatty oil, can lubricate intestinal tract and is beneficial to defecation. It belongs to a lubricating cathartic.

4. The peach kernel extract for protecting liver and resisting liver cirrhosis can prevent lipid peroxidation damage of animals caused by alcohol, carbon tetrachloride and Fe2+ -cysteine. Can reduce the quantity of the hepatic collagen of the schistosomiasis liver cirrhosis rabbits, the fiber cell fusion and the fibrosis in a convergent area, and simultaneously has the prevention and treatment effect on experimental hepatic fibrosis. Amygdalin is considered as an anti-hepatic fibrosis component, and can increase hepatic blood flow and improve hepatic tissue collagenase activity, thereby promoting hepatic collagen catabolism.

5. The peach kernel water extract with the functions of resisting inflammation and relieving pain can obviously inhibit the writhing reaction of mice, and various organic solvent extracts also have the function of relieving pain. The peach kernel water extract has obvious inhibition effect on various experimental inflammations (foot sole edema caused by egg white, granuloma caused by carrageenan and auricle swelling caused by xylene). The anti-inflammatory component is thought to be amygdalin.

Bletilla striata (pharmacological action)

The efficacy of the transmitter is as follows: bletilla striata can enhance the activity of a third factor of blood platelet, obviously shorten the blood coagulation time and the prothrombin formation time, inhibit the activity of plasmin and have the hemostatic effect on local bleeding; animal experiments show that the rhizoma bletillae water extract has good hemostatic effect on external rhizoma bletillae such as parenchyma organ (liver, spleen) and muscle blood vessel hemorrhage.

2. Protecting gastric mucosa: 1% of bletilla striata decoction is filled into the stomach, and the injury of rat gastric mucosa caused by hydrochloric acid is protected; has therapeutic effect on experimental gastric and duodenal perforation of anesthetized dogs.

⒊ antibacterial, antifungal action: the rhizoma Bletillae ethanol extract has inhibitory effect on Staphylococcus aureus, bacillus subtilis, and human type tubercle bacillus; the water infusion has an inhibitory effect on Ostreatia ozolopsis; 3 biphenyl compounds and 2 dihydrophenanthrene compounds contained in the bletilla striata have inhibitory effects on staphylococcus aureus, bacillus subtilis, candida albicans ATCC1057 and trichophyton QM 248.

4. The anti-cancer and anti-cancer effects are as follows: the part of the mucilage of rhizoma bletillae (mainly comprising polysaccharide) is injected into the abdominal cavity to inhibit Wake's carcinoma (W256) of rat, cervical cancer (U14) of mouse and Ehrlich carcinoma of mouse; the bletilla striata injection has obvious inhibition effect on rat Dimethylamino Azobenzene (DAB) induced liver cancer.

Herba Artemisiae Scopariae [ pharmacological action ]

(1) The clinical application of cholagogic and animal experiments show that the capillary artemisia has obvious cholagogic and jaundice-removing effects. Herba Artemisiae Scopariae can obviously increase bile flow of cholelithiasis patient, reduce cholesterol content in bile, and prevent formation of cholesterol calculus. The compound preparation has the functions of promoting bile secretion and excretion for normal experimental animals and rats with liver injury caused by CCl 4. The effective components of herba Artemisiae Scopariae with choleretic effect mainly include herba Artemisiae Scopariae coumaric acid A, medicolegal education network collecting and sorting B and 6,7-dimethoxycoumarin, herba Artemisiae Scopariae chromone, herba Artemisiae Scopariae flavone, herba Artemisiae Scopariae diyne ketone, herba Artemisiae Scopariae alkynolide, chlorogenic acid, caffeic acid, p-hydroxyacetophenone, etc.

(2) The herba Artemisiae Scopariae decoction for protecting liver has protective effect on animal experimental liver injury caused by CCl4, and can reduce serum transaminase activity, and relieve hepatocyte swelling, ballooning change, lipogenesis and necrosis. Capillary artemisia chromone, 6,7-dimethoxy coumarin, capillary artemisia flavone and the like have the effect of protecting the liver. The mechanism of action of liver protection may be: inducing liver drug enzyme, enhancing liver detoxification function, protecting integrity of liver cell membrane, and promoting regeneration of liver cell.

(3) The anti-pathogenic microorganism artemisia capillaris has stronger anti-pathogenic microorganism effect and has obvious inhibition effect on staphylococcus aureus in vitro. Has certain inhibiting effect on dysentery bacillus, hemolytic streptococcus, diplococcus pneumoniae, diphtheria bacillus, bovine and human tubercle bacillus, escherichia coli, typhoid bacillus, pseudomonas aeruginosa, bacillus subtilis, pathogenic filament, and dermatophytes such as Aspergillus flavus and Aspergillus versicolor. The herba Artemisiae Scopariae antibacterial active ingredient mainly comprises capillone, p-hydroxyacetophenone and other volatile oil components.

(4) The herba Artemisiae Scopariae can reduce blood lipid and atherosclerosis, reduce serum cholesterol and beta-lipoprotein of animals with hyperlipemia, reduce cholesterol content in aortic wall, and relieve atherosclerotic plaque lesion.

(5) The antipyretic, analgesic and anti-inflammatory herba Artemisiae Scopariae has obvious antipyretic effect on rabbit body temperature increase caused by typhoid mixed vaccine, and 6,7-dimethylesculin in herba Artemisiae Scopariae has certain analgesic effect on mouse pain model caused by hot plate method and acetic acid writhing method, and has inhibitory effect on rat foot joint swelling degree caused by carrageenan.

Pollen Pini (pharmacological action)

(1) And (3) fatigue resistance: the pine pollen contains comprehensive and balanced nutrition, and can enhance physical strength and energy and recover fatigue comprehensively. Through some experiments, the pine pollen is beneficial to middle-aged and elderly people who are easy to fatigue or workers engaged in super-strong physical strength.

(2) And (3) delaying aging: pollen Pini contains a large amount of antioxidant components such as vitamin E, carotene and selenium, which can inhibit the peroxidation of lipid and protein in vivo, thereby delaying aging. And tests also show that: the frequent taking of the pine pollen can eliminate senile plaques and restore the youth activity of a human body, which is the reason that the pine pollen can lighten the body after being taken for a long time and prolong the life.

(3) And (3) beautifying: the pine pollen not only has unique physiological regulation function, but also has the special effects of promoting the metabolism of skin cells, delaying the aging of the skin cells, increasing the elasticity of the skin and enabling the skin to be white, ruddy and healthy, and is praised as 'edible cosmetics'.

(4) Relieving constipation: the pine pollen contains abundant and complete nutrients and has good treatment effect on constipation. For example, for constipation caused by dyspepsia and upper gastrointestinal diseases, the pine pollen has good curative effect on gastrointestinal dysfunction, so after the pine pollen is taken, the constipation can be immediately improved. For constipation caused by involuntary muscle spasm due to nervous tension, magnesium and vitamin B6 in pollen Pini have good tranquilizing effect on involuntary muscle, so that constipation can be eliminated naturally.

Tea seeds (pharmacological action)

1. The tea seed has the important effects of relieving swelling, alleviating pain, relieving swelling and alleviating pain, contains various medicinal components, can reduce the sensitivity of a human body to pain, can quickly relieve the swelling and pain symptoms of the human body, can take out the grease in the tea seeds to directly apply the grease to an affected part when people have adverse symptoms such as chronic eczema, dermatitis, eczema and the like at ordinary times, can relieve uncomfortable symptoms, can also treat burn and scald by using the grease in the tea seeds, and has a particularly good treatment effect.

2. The tea seeds have the effects of relaxing bowel, relaxing bowel and relaxing bowel, and have a certain benefit on maintaining the health of human intestinal tracts because the grease contained in the tea seeds has an obvious lubricating effect on the human intestinal tracts, can shorten the defecation time of human bodies and accelerate the discharge of garbage and toxins in the human bodies.

3. The wild tea seeds for preventing arteriosclerosis contain a lot of oleic acid, stearic acid, linoleic acid and other substances which are more than those of common vegetable oil, the wild tea seeds are pressed into oil and then fried with the pressed oil, so that the wild tea seeds have a great protection effect on heart vessels and can prevent arteriosclerosis. The old people preferably eat wild tea seed oil.

4. The wild tea seeds for moistening hair contain a lot of oleic acid, which can play a role in moistening hair, and meanwhile, the wild tea seeds contain a lot of linoleic acid and linoleic acid, which can maintain the growth of hair and have the function of preventing hair loss. Therefore, people with serious hair loss and baldness can take the wild tea seeds for hair care.

5. The wild tea seeds also have the beautifying effect because the content of vitamin E in the wild tea seeds is extremely high and is many times higher than that in common vegetable oil. Vitamin E is an antioxidant, and has skin caring effect. The skin can be made more elastic by eating the wild tea seeds frequently, and the wrinkles on the face can be eliminated.

6. The proportion of linoleic acid and linolenic acid contained in the wild tea seeds for regulating immunity is proper, the wild tea seeds conform to international standards, excessive unsaturated fatty acid oxidation in vivo cannot be caused, and the wild tea seeds have conditional effect on the immunologic function of a body. The wild tea seeds also contain a substance called squalene, which can play a role in resisting fatigue, and the fatigue can be eliminated and the aging of the body can be delayed when people eat the wild tea seeds.

Semen astragali Complanati [ pharmacological action ]

1. The water extract and alcohol extract of the white arrowhead goosefoot have the effect of reducing blood pressure of anesthetized animals. The quinoa has cholinesterase resisting activity, and can enhance cholinergic nerve function, and oral atropine can block its blood pressure lowering effect.

2. Has obvious effect of resisting myocardial ischemia on the heart and blood fat caused by the arrowhead saponins.

The total saponins of rhizoma Et radix Tribuli have effects in preventing deposition of lipid in artery, myocardium and liver, and increasing the ratio of lecithin to cholesterol. Reduce serum cholesterol and blood glucose levels.

3. The anti-aging effect of the total saponins of the arrowhead goosefoots can increase the weight of the liver and the thymus of the mouse, and obviously improve the deposition and accumulation of pigment particles in the spleen of the aged mouse. The oral liquid is continuously taken for 35 days, and has effects of inhibiting weight loss, spleen atrophy and thymus gland atrophy in mice subacute aging model caused by D-galactose. The arrowhead goosefoot saponin can prolong the swimming time of mice.

4. The semen production function of the white arrowhead goosefoot is that the main component of the white arrowhead goosefoot is the barksterol disaccharide glycoside which can promote the formation of sperms of male rats and enhance sexual reflex and libido.

5. Others are

(1) The arrowhead goosefoots have moderate diuretic effect and are related to the biological potassium salt contained in the goosefoots.

(2) The rhizoma Tribuli alkaloid and water soluble part can resist acetylcholine and inhibit small intestine movement.

(3) The extract of the white arrowhead gooseberry with antibacterial effect has the effect of inhibiting various respiratory tract pathogenic bacteria.

Pearl powder (pharmacological action)

1. Relieving uneasiness of mind and tranquilizing mind: the pearl powder has the effects of relieving palpitation and soothing nerves, and is used for treating the patient with fright;

2. clearing liver and improving vision: the pearl powder enters liver meridian to clear away fire heat of liver meridian;

3. detoxification and tissue regeneration: the pearl powder is used in time for treating knife wound, abrasion, burn and the like, and the hemostatic and anti-inflammatory effects are quick;

4. maintaining beauty and keeping young: the pearl powder contains various amino acids such as glycine, proline, cystine and the like, which is helpful for keeping skin elasticity and making skin whiter and ruddy. In addition, microelements such as copper, zinc, and manganese in Margarita powder can enhance skin antioxidant function and reduce melanin generation.

As shown in fig. 1, a preparation method of a traditional Chinese medicine preparation for treating seborrheic alopecia provided by the embodiment of the invention comprises the following steps:

s101: according to the corresponding weight, 30g of tuckahoe, 15g of angelica dahurica, 30g of gordon euryale seed, 10g of white muscardine silkworm, 10g of peach kernel, 15g of bletilla striata, 10g of oriental wormwood, 20g of pine pollen, 10g of tea seed, 10g of flatstem milkvetch seed and 6g of pearl powder are mixed, and the mixture is cleaned and dried.

S102: 30g of poria cocos, 15g of angelica dahurica, 30g of gordon euryale seed, 10g of white muscardine silkworm, 10g of peach seed, 15g of bletilla striata, 10g of oriental wormwood, 20g of pine pollen, 10g of tea seed, 10g of flatstem milkvetch seed and 6g of pearl powder are sieved by sieving.

S103: after the sieving is finished, grinding the mixture; and stored.

In S101 provided by the embodiment of the present invention, a specific process of cleaning and drying the mixture includes:

putting the medicine mixture into a cleaning and stirring device, and stirring by using a stirring shaft;

after stirring, the drug mixture is filtered by a filtering device and dispersed and dried.

In S102 provided by the embodiment of the present invention, the specific process of sieving the mixture is as follows:

and putting the mixture into a sieving device, and vibrating by using a vibrating motor to realize sieving of the mixture.

The sieving device is a fine sieve with 180 meshes and is stored for later use.

In order to prove the creativity and the technical value of the technical scheme of the invention, the part is the application example of the technical scheme of the claims on specific products or related technologies.

Case one: guo Mou, female, age 46, date of first visit 2018, 4 months and 6 days, symptoms: alopecia, pruritus, desquamation, greasy skin, thirst and restlessness. Treatment: decoction for clearing lung-heat and stomach-heat, for external use: 30g of poria cocos, 15g of angelica dahurica, 30g of gordon euryale seed, 10g of white muscardine silkworm, 10g of peach seed, 15g of bletilla striata, 10g of oriental wormwood, 20g of pine pollen, 10g of tea seed, 10g of flatstem milkvetch seed and 6g of pearl powder, and the external medicine is used for dissolving fat, exfoliating keratin, diminishing inflammation, relieving itching, dispelling dampness, detoxifying, clearing heat and cooling blood. The external and internal use of the medicine can cure the disease after 5 months, and all symptoms disappear.

Case two: jiang Mou, female, age 56, initial diagnosis date 2021, 7 months and 19 days, symptoms: dark yellow urine, preference for cold drink and fantod, erythema on the face, chest, axilla, groin and breast, desquamation, pachynsis, lichen deformation, scaling and scabbing. The patient is in a stomach-lung heat type, is treated by taking decoction for clearing lung-stomach heat and relieving itching, is orally taken, and is treated by processing 30g of poria cocos, 15g of angelica dahurica, 30g of gordon euryale seed, 10g of white muscardine silkworm, 10g of peach kernel, 15g of bletilla striata, 10g of oriental wormwood, 20g of pine pollen, 10g of tea seed, 10g of flatstem milkvetch seed and 6g of pearl powder for external use, and treating more than three months by using 30g of poria cocos, 15g of angelica dahurica, 30g of gordon euryale seed, 10g of white muscardine silkworm, 10g of peach kernel, 15g of bletilla striata, 10g of oriental wormwood, 20g of pine pollen, 10g of tea seed, 10g of flatstem milkvetch seed and 6g of pearl powder.

Case three: forest, male, 30 years old, initial diagnosis date of 2019, 10 months and 24 days, symptoms: alopecia, pimples, blisters, erosion, crusting on the forehead. The oral decoction is prepared from 30g of poria cocos, 15g of angelica dahurica, 30g of gordon euryale seed, 10g of white muscardine silkworm, 10g of peach kernel, 15g of bletilla striata, 10g of oriental wormwood, 20g of pine pollen, 10g of tea seed, 10g of flatstem milkvetch seed and 6g of pearl powder, and is externally used after being processed so as to treat a series of dermatitis symptoms caused by the obstruction of hair follicles and sebaceous glands and the change of the hair follicles.

The embodiment of the invention achieves some positive effects in the process of research and development or use, and has great advantages compared with the prior art, and the following contents are described by combining data, diagrams and the like in the test process.

Compared with the prior art, the implementation case has the advantages of four aspects:

diminishing inflammation, relieving itching, dissolving fat, removing cutin, and treating and controlling secondary infection.

Clean and moisten, rebuild healthy micro-ecology of hair follicles and promote hair growth.

Tightening skin, improving loose skin tension, and promoting skin metabolism.

Regulating acid-base balance of skin, and promoting healthy secretion of sebaceous gland.

The above description is only for the purpose of illustrating the present invention and the appended claims are not to be construed as limiting the scope of the invention, which is intended to cover all modifications, equivalents and improvements that are within the spirit and scope of the invention as defined by the appended claims.

Claims (10)

1. A preparation method of a traditional Chinese medicine preparation for treating seborrheic alopecia is characterized in that the preparation method of the traditional Chinese medicine preparation for treating the seborrheic alopecia comprises the following steps:

step one, mixing 30g of poria cocos, 15g of radix angelicae, 30g of semen euryales, 10g of white muscardine silkworm, 10g of peach kernel, 15g of bletilla striata, 10g of oriental wormwood, 20g of pine pollen, 10g of tea seeds, 10g of flatstem milkvetch seed and 6g of pearl powder according to corresponding weight, and cleaning and airing the mixture;

sieving a mixture of 30g of poria cocos, 15g of radix angelicae, 30g of semen euryales, 10g of white muscardine silkworm, 10g of peach kernel, 15g of bletilla striata, 10g of oriental wormwood, 20g of pine pollen, 10g of tea seeds, 10g of flatstem milkvetch seed and 6g of pearl powder by utilizing a sieve;

step three, grinding the mixture after the sieving is finished; making rice flour into blank and wrapping with rice flour to obtain wine blank; rolling a layer of fine rice flour on the wine base, putting the wine base into the yeast chamber to promote the yeast propagation in the yeast base, and storing.

2. The method for preparing a Chinese medicinal preparation for treating seborrheic alopecia as claimed in claim 1, wherein in the first step, the specific process of washing and drying the mixture comprises:

putting the medicine mixture into a cleaning and stirring device, and stirring by using a stirring shaft;

after stirring, the drug mixture is filtered by a filtering device and dispersed and dried.

3. The method for preparing a chinese medicinal preparation for the treatment of seborrheic alopecia as set forth in claim 1, wherein in the second step, the mixture is sieved by the following specific procedures:

and putting the mixture into a sieving device, and vibrating by using a vibrating motor to realize sieving of the mixture.

4. The method for preparing a Chinese medicinal preparation for treating seborrheic alopecia as recited in claim 3, wherein said sieving device is a 180-mesh fine sieve.

5. The method for preparing a chinese medicinal preparation for treating seborrheic alopecia as claimed in claim 1, wherein in said step two, the steps of making rice flour into a base and wrapping the rice flour with rice flour are as follows:

using 3/4 of rice flour as blank, using the rest 1/4 of rice flour as wrapping powder, wrapping the Chinese medicinal powder with 3% of the blank powder and 60% of water, and stirring.

6. The method for preparing a Chinese medicinal preparation for treating seborrheic alopecia as claimed in claim 1, wherein in the third step, the specific process of preparing the wine base comprises:

cutting the wine cake into 2 cm-sized grains, and sieving with a bamboo sieve to obtain wine blank.

7. The method for preparing a chinese medicinal preparation for treating seborrheic alopecia according to claim 1, wherein in the third step, rolling a layer of fine rice flour on the wine base comprises the following specific steps:

rolling a layer of fine rice flour outside the yeast blank, and controlling the water content of the wine blank to be 56%.

8. The method for preparing a Chinese medicinal preparation for treating seborrheic alopecia as claimed in claim 1, wherein in the third step, the wine base is put into the yeast chamber, and the specific process for promoting the propagation of yeast in the yeast base comprises:

the wine base is sent into a yeast chamber, and the room temperature is controlled within a certain range; after culturing for 20 hours, the mold hyphae grow vigorously, the product temperature is controlled to be 33-34 ℃, and the maximum temperature is not more than 37 ℃; after culturing for 24 hours, controlling the room temperature at 28-30 ℃ and keeping the product temperature below 35 ℃ for 24 hours in order to promote the yeast in the yeast blank to propagate; after 48 hours, the product temperature is reduced and the yeast is mature;

the control of the room temperature within a certain range in the 20-hour culture process specifically comprises the following steps: 28 to 31 ℃.

9. The method for preparing a Chinese medicinal preparation for treating seborrheic alopecia as claimed in claim 1, wherein the storage in the third step is specifically carried out as follows:

taking out the mature yeast, drying or sun-drying in a drying room, and storing for later use.

10. The traditional Chinese medicine preparation for treating seborrheic alopecia, which is prepared by the preparation method of the traditional Chinese medicine preparation for treating seborrheic alopecia according to any one of claims 1 to 9, is characterized by comprising, by weight, 30g of poria cocos, 15g of radix angelicae, 30g of semen euryales, 10g of white muscardine silkworm, 10g of peach kernels, 15g of bletilla striata, 10g of oriental wormwood, 20g of pine pollen, 10g of tea seeds, 10g of flastem milkvetch seed and 6g of pearl powder.

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