CN115337248A

CN115337248A - Formula and preparation method of toothpaste for remineralizing enamel

Info

Publication number: CN115337248A
Application number: CN202210919294.2A
Authority: CN
Inventors: 张亚南
Original assignee: Henan Ciren Biotechnology Research Institute Co ltd
Current assignee: Henan Ciren Biotechnology Research Institute Co ltd
Priority date: 2022-08-01
Filing date: 2022-08-01
Publication date: 2022-11-15

Abstract

The invention discloses a formula of toothpaste for remineralizing tooth enamel and a preparation method thereof, the preparation method of the toothpaste for remineralizing tooth enamel comprises the steps of sucking polyethylene glycol, sorbitol and xylitol into a glue making pot, adding xanthan gum, fully wetting, then adding water and other water-soluble additives under high-speed stirring, then continuously stirring, storing for later use after the glue is uniform and transparent and has no particles, putting the prepared glue into a kneader, adding silicon dioxide, sodium lauroyl sarcosinate, cripple carrageenan, propolis, trichlorogalactose, sodium pyrophosphate, potassium sorbate, sodium benzoate, menthol, hydroxyapatite, dextranase and essence, kneading uniformly to form paste, sending the kneaded paste into a colloid mill for grinding, further homogenizing and dispersing aggregation groups of the colloid under mechanical shearing, uniformly distributing various particles in the paste and the like.

Description

Formula and preparation method of toothpaste for remineralizing enamel

Technical Field

The invention relates to the technical field of toothpaste production, in particular to a formula and a preparation method of toothpaste for remineralizing enamel.

Background

The deciduous teeth begin to sprout in 6-7 months after birth of a human, and the development of the deciduous dentition is completed in 3-6 years old, namely the deciduous dentition stage is in 6-6 months old. The 6-12 year old is the stage of mixed dentition, wherein the deciduous teeth are fallen off and the permanent teeth are erupted in turn until all the deciduous teeth are replaced.

At this stage, both deciduous teeth and permanent teeth exist in the oral cavity, which is the main growth and development period of the jaw and dental arch of children and the key period for establishing the permanent tooth jaw. Compared with permanent tooth decay, the primary tooth decay has the characteristics of early onset, wide range, fast development speed, unobvious subjective symptoms and the like.

The main relevant factors of susceptibility of deciduous teeth to caries are: the number of times a child eats a sweet food per day and the intensity of oral cleansing. In the daytime, children frequently eat the food, the food is soft food, the food is strong in viscosity and high in sugar content, the soil is rich in bacteria, bacterial plaque is easily formed, a large amount of bacteria ingest sugar in saliva to decompose the sugar to generate acid, the acidity of the saliva is increased after eating, the saliva is in an acidic state for a long time after eating for many times, and the decayed tooth is more easily suffered than eating the same amount of food for one time. The children have long sleep time, the oral cavity is in a static state, the saliva secretion is less, the self-cleaning effect is poor, the bacterial reproduction is facilitated, and the probability of caries is increased.

The existing toothpaste has a cleaning effect, but does not make corresponding improvement on the different day and night oral cavity environments of children.

Disclosure of Invention

This section is for the purpose of summarizing some aspects of embodiments of the invention and to briefly introduce some preferred embodiments. In this section, as well as in the abstract and title of the application, simplifications or omissions may be made to avoid obscuring the purpose of the section, the abstract and the title, and such simplifications or omissions are not intended to limit the scope of the invention.

The present invention has been made in view of the above and/or other problems with existing toothpastes.

Therefore, the invention aims to provide a formula of toothpaste for remineralizing enamel and a preparation method thereof, which are completely suitable for children, maintain the oral microecological balance, balance the oral pH value, prevent decayed teeth and strengthen teeth.

To solve the above technical problem, according to an aspect of the present invention, the present invention provides the following technical solutions:

the formula of the toothpaste for remineralizing enamel comprises the following components in percentage by mass:

sorbitol: 58-62wt%, polyethylene glycol: 4-6wt%, silica: 14-16wt%, CMC:0.6-0.8wt%, xanthan gum: 0.2-0.4wt%, sodium lauroyl sarcosinate: 0.8-1.2wt%, carrageen crispa: 0.9-1.1wt%, propolis: 2-4wt%, trichlorogalactose: 0.24 to 0.26wt%, sodium pyrophosphate: 0.2-0.4wt%, potassium sorbate: 0.09-0.11wt%, sodium benzoate: 0.19-0.22wt%, menthol: 0.09-0.12wt%, xylitol: 1.8-2.2wt%, hydroxyapatite: 0.09-0.12wt%, dextran enzyme: 0.06-0.08wt%, essence: 0.5-0.7wt% and the balance of water.

As a preferable scheme of the toothpaste formula for remineralizing tooth enamel, the preferable scheme comprises the following components in percentage by mass: sorbitol: 60wt%, polyethylene glycol: 5wt%, silica: 15wt%, CMC:0.7wt%, xanthan gum: 0.3wt%, sodium lauroyl sarcosinate: 1wt%, chondrus crispus: 1wt%, propolis: 3wt%, trichlorogalactose: 0.25wt%, sodium pyrophosphate: 0.3wt%, potassium sorbate: 0.1wt%, sodium benzoate: 0.2wt%, menthol: 0.1wt%, xylitol: 2wt%, hydroxyapatite: 0.1wt%, dextranase: 0.07wt%, essence: 0.6wt% and the balance water.

A preparation method of a toothpaste formula for remineralizing enamel comprises the following specific steps:

s1, sucking 4-6wt% of polyethylene glycol, 58-62wt% of sorbitol and 1.8-2.2wt% of xylitol into a glue making pot, adding 0.6-0.8wt% of CMC and 0.2-0.4wt% of xanthan gum for fully wetting, then adding water and other water-soluble additives under the condition of high-speed stirring, then continuously stirring until the glue is uniform and transparent and has no granules, and storing for standby;

s2, putting the glue prepared in the step S1 into a kneader, adding 14-16wt% of silicon dioxide, 0.8-1.2wt% of sodium lauroyl sarcosinate, 0.9-1.1wt% of wrinkled giant-wave carrageen, 2-4wt% of propolis, 0.24-0.26wt% of trichlorogalactose, 0.2-0.4wt% of sodium pyrophosphate, 0.09-0.11wt% of potassium sorbate, 0.19-0.22wt% of sodium benzoate, 0.09-0.12wt% of menthol, 0.09-0.12wt% of hydroxyapatite, 0.06-0.08wt% of dextranase and 0.5-0.7wt% of essence, and kneading uniformly to form a paste;

s3, feeding the kneaded paste body into a colloid mill for grinding, and further homogenizing and dispersing the aggregation groups of the colloid under mechanical shearing to uniformly distribute various particles in the paste body;

and S4, filling and packaging the paste ground in the step S3 after vacuum degassing treatment.

As a preferable embodiment of the preparation method of the enamel remineralization toothpaste formulation according to the present invention, in step S1, the specific steps of storing for later use are as follows: injecting into a glue storage tank, and standing for a period of time to further homogenize the mucus.

As a preferable embodiment of the preparation method of the enamel remineralization toothpaste formulation according to the present invention, in the step S3, the kneaded paste is fed into a colloid mill by a gear pump or a reciprocating pump.

Compared with the prior art, the invention has the following beneficial effects: the formula and the preparation method of the toothpaste capable of remineralizing the dental enamel are completely suitable for children, maintain the micro-ecological balance of the oral cavity, balance the pH value of the oral cavity, prevent decayed teeth and solidify teeth, and relieve the pungent taste in the toothpaste by adding sweet oranges and other sweetening agents, so that the children are prevented from resisting the toothpaste.

Drawings

In order to more clearly illustrate the technical solutions of the embodiments of the present invention, the present invention will be described in detail below with reference to the accompanying drawings and detailed embodiments, and it is obvious that the drawings in the following description are only some embodiments of the present invention, and it is obvious for those skilled in the art to obtain other drawings without inventive exercise. Wherein:

fig. 1 is a flow chart of a method of preparing an enamel remineralization toothpaste formulation of the present invention.

Detailed Description

In order to make the aforementioned objects, features and advantages of the present invention comprehensible, embodiments accompanied with figures are described in detail below.

Next, the present invention is described in detail with reference to the drawings, and in the detailed description of the embodiments of the present invention, the cross-sectional view illustrating the structure of the device is not enlarged partially in general scale for the convenience of illustration, and the drawings are only exemplary, which should not limit the scope of the present invention. In addition, the three-dimensional dimensions of length, width and depth should be included in the actual fabrication.

In order to make the objects, technical solutions and advantages of the present invention more apparent, embodiments of the present invention will be described in detail with reference to the accompanying drawings.

The invention provides a formula of toothpaste for remineralizing enamel and a preparation method thereof, which are completely suitable for children, maintain the micro-ecological balance of the oral cavity, balance the pH value of the oral cavity, prevent decayed teeth and strengthen teeth.

The formula of the toothpaste for remineralizing enamel comprises sorbitol: 58-62wt%, polyethylene glycol: 4-6wt%, silica: 14-16wt%, CMC:0.6-0.8wt%, xanthan gum: 0.2-0.4wt%, sodium lauroyl sarcosinate: 0.8-1.2wt%, carrageen crispa: 0.9-1.1wt%, propolis: 2-4wt%, trichlorogalactose: 0.24 to 0.26wt%, sodium pyrophosphate: 0.2-0.4wt%, potassium sorbate: 0.09-0.11wt%, sodium benzoate: 0.19-0.22wt%, menthol: 0.09-0.12wt%, xylitol: 1.8-2.2wt%, hydroxyapatite: 0.09-0.12wt%, dextran enzyme: 0.06-0.08wt%, essence: 0.5-0.7wt% and the balance of water.

Specifically, the composite material comprises the following components in percentage by mass: sorbitol: 60wt%, polyethylene glycol: 5wt%, silica: 15wt%, CMC:0.7wt%, xanthan gum: 0.3wt%, sodium lauroyl sarcosinate: 1wt%, chondrus crispus: 1wt%, propolis: 3wt%, trichlorogalactose: 0.25wt%, sodium pyrophosphate: 0.3wt%, potassium sorbate: 0.1wt%, sodium benzoate: 0.2wt%, menthol: 0.1wt%, xylitol: 2wt%, hydroxyapatite: 0.1wt%, dextranase: 0.07wt%, essence: 0.6wt% and the balance water.

Example 1

Weighing sorbitol: 58wt%, polyethylene glycol: 4wt%, silica: 14wt%, CMC:0.6wt%, xanthan gum: 0.2wt%, sodium lauroyl sarcosinate: 0.8wt%, chondrus crispus: 0.9wt%, propolis: 2wt%, trichlorogalactose: 0.24wt%, sodium pyrophosphate: 0.2wt%, potassium sorbate: 0.09wt%, sodium benzoate: 0.19wt%, menthol: 0.09wt%, xylitol: 1.8wt%, hydroxyapatite: 0.09wt%, dextranase: 0.06wt%, essence: 0.5wt%, balance water.

S1, sucking 4wt% of polyethylene glycol, 58wt% of sorbitol and 1.8wt% of xylitol into a glue making pot, adding 0.6wt% of CMC and 0.2wt% of xanthan gum for fully wetting, then adding water and other water-soluble additives under high-speed stirring, then continuing stirring, and after the glue is uniform and transparent and has no particles, putting the glue into a glue storage tank for a period of time to further homogenize the viscose;

s2, putting the glue prepared in the step S1 into a kneader, adding 14wt% of silicon dioxide, 0.8-1.2wt% of sodium lauroyl sarcosine, 0.9wt% of crinkle carrageenan, 2wt% of propolis, 0.24wt% of trichlorogalactose, 0.2wt% of sodium pyrophosphate, 0.09wt% of potassium sorbate, 0.19wt% of sodium benzoate, 0.09wt% of menthol, 0.09wt% of hydroxyapatite, 0.06wt% of dextranase and 0.5wt% of essence, and kneading uniformly to form a paste;

s3, feeding the kneaded paste body into a colloid mill through a gear pump or a reciprocating pump for grinding, and further homogenizing and dispersing the aggregation groups of the colloid under mechanical shearing to uniformly distribute various particles in the paste body;

and S4, carrying out vacuum degassing treatment on the paste ground in the step S3, and then filling and packaging.

Example 2

Weighing sorbitol: 60wt%, polyethylene glycol: 5wt%, silica: 15wt%, CMC:0.7wt%, xanthan gum: 0.3wt%, sodium lauroyl sarcosinate: 1wt%, chondrus crispus: 1wt%, propolis: 3wt%, trichlorogalactose: 0.25wt%, sodium pyrophosphate: 0.3wt%, potassium sorbate: 0.1wt%, sodium benzoate: 0.2wt%, menthol: 0.1wt%, xylitol: 2wt%, hydroxyapatite: 0.1wt%, dextranase: 0.07wt%, essence: 0.6wt% and the balance water.

S1, sucking 5wt% of polyethylene glycol, 60wt% of sorbitol and 2wt% of xylitol into a glue making pot, adding 0.7wt% of CMC and 0.3wt% of xanthan gum for fully wetting, then adding water and other water-soluble additives under high-speed stirring, continuing stirring, and after the glue is uniform and transparent and has no particles, putting the glue into a glue storage tank for a period of time to further homogenize the viscose;

s2, putting the glue prepared in the step S1 into a kneader, adding 15wt% of silicon dioxide, 1wt% of sodium lauroyl sarcosinate, 1wt% of crinkle carrageenan, 3wt% of propolis, 0.25wt% of trichlorogalactose, 0.3wt% of sodium pyrophosphate, 0.1wt% of potassium sorbate, 0.2wt% of sodium benzoate, 0.1wt% of menthol, 0.1wt% of hydroxyapatite, 0.07wt% of dextranase and 0.6wt% of essence, and kneading uniformly to form a paste;

Example 3

Weighing sorbitol: 62wt%, polyethylene glycol: 6wt%, silica: 16wt%, CMC:0.8wt%, xanthan gum: 0.4wt%, sodium lauroyl sarcosinate: 1.2wt%, chondrus crispus: 1.1wt%, propolis: 4wt%, trichlorogalactose: 0.26wt%, sodium pyrophosphate: 0.4wt%, potassium sorbate: 0.11wt%, sodium benzoate: 0.22wt%, menthol: 0.12wt%, xylitol: 2.2wt%, hydroxyapatite: 0.12wt%, dextranase: 0.08wt%, essence: 0.7wt%, and the balance water.

S1, sucking 6wt% of polyethylene glycol, 62wt% of sorbitol and 2.2wt% of xylitol into a glue making pot, adding 0.8wt% of CMC and 0.4t% of xanthan gum for fully wetting, then adding water and other water-soluble additives under high-speed stirring, then continuing stirring, and after the glue is uniform and transparent and has no particles, putting the glue into a glue storage tank for a period of time to further homogenize the viscose;

s2, putting the glue prepared in the step S1 into a kneader, adding 16wt% of silicon dioxide, 1.2wt% of sodium lauroyl sarcosinate, 1.1wt% of crinkle carrageenan, 4wt% of propolis, 0.26wt% of trichlorogalactose, 0.4wt% of sodium pyrophosphate, 0.11wt% of potassium sorbate, 0.22wt% of sodium benzoate, 0.12wt% of menthol, 0.12wt% of hydroxyapatite, 0.08wt% of dextranase and 0.7wt% of essence, and kneading uniformly to form a paste;

While the invention has been described with reference to an embodiment, various modifications may be made and equivalents may be substituted for elements thereof without departing from the scope of the invention. In particular, the various features of the disclosed embodiments of this invention can be used in any combination as long as there is no structural conflict, and the combination is not exhaustively described in this specification merely for the sake of brevity and resource savings. Therefore, it is intended that the invention not be limited to the particular embodiments disclosed, but that the invention will include all embodiments falling within the scope of the appended claims.

Claims

1. The formula of the toothpaste for remineralizing enamel is characterized by comprising the following components in percentage by mass:

2. The enamel remineralizing toothpaste formulation according to claim 1, comprising, in mass proportions: sorbitol: 60wt%, polyethylene glycol: 5wt%, silica: 15wt%, CMC:0.7wt%, xanthan gum: 0.3wt%, sodium lauroyl sarcosinate: 1wt%, chondrus crispus: 1wt%, propolis: 3wt%, trichlorogalactose: 0.25wt%, sodium pyrophosphate: 0.3wt%, potassium sorbate: 0.1wt%, sodium benzoate: 0.2wt%, menthol: 0.1wt%, xylitol: 2wt%, hydroxyapatite: 0.1wt%, dextranase: 0.07wt%, essence: 0.6wt% and the balance water.

3. A method of preparing an enamel remineralizing toothpaste formulation according to any one of claims 1-2 comprising the steps of:

s1, sucking 4-6wt% of polyethylene glycol, 58-62wt% of sorbitol and 1.8-2.2wt% of xylitol into a glue making pot, adding 0.6-0.8wt% of CMC and 0.2-0.4wt% of xanthan gum for fully wetting, then adding water and other water-soluble additives under high-speed stirring, continuing stirring, and storing for later use after the glue is uniform and transparent and has no particles;

s2, putting the glue prepared in the step S1 into a kneader, adding 14-16wt% of silicon dioxide, 0.8-1.2wt% of sodium lauroyl sarcosinate, 0.9-1.1wt% of crinkle carrageenan, 2-4wt% of propolis, 0.24-0.26wt% of trichlorogalactose, 0.2-0.4wt% of sodium pyrophosphate, 0.09-0.11wt% of potassium sorbate, 0.19-0.22wt% of sodium benzoate, 0.09-0.12wt% of menthol, 0.09-0.12wt% of hydroxyapatite, 0.06-0.08wt% of dextranase and 0.5-0.7wt% of essence, and kneading uniformly to form a paste;

4. The method of preparing an enamel remineralizing dentifrice formulation according to claim 3, wherein said step S1, storing for use, comprises the steps of: and (5) injecting the mixture into a glue storage tank for a period of time to further homogenize the mucus.

5. The method for preparing an enamel remineralizing dentifrice formulation according to claim 3, wherein the kneaded paste of step S3 is fed into a colloid mill by a gear pump or a reciprocating pump.