RU2635529C1 - Preventative composition for children's teeth treatment - Google Patents

Abstract

FIELD: medicine.

SUBSTANCE: invention is a preventative composition for children's teeth treatment, contains synthetic thin-dispersed amorphous silicon dioxide, synthetic amorphous thin-dispersed silicon dioxide with 1-6 mcm particles, sorbitol/glycerin, sodium carboxymethyl cellulose, sodium benzoate, sodium myristoilsarcosinate and sodium methylcocoyltaurate, sodium saccharin, trisodium phosphate, combined product Polyplant baby, containing plant extracts: calendula, chamomile, mimosa and sweet violet and D-panthenol, carbomer, sodium fluoride, trilon b, aromatic composition, stainer - titanium dioxide and water, with components in the composition being in a specific ratio in wt %.

EFFECT: increased cleaning ability, without harming the tooth surface, and safety in case of accidental ingestion.

1 tbl, 1 dwg

Description

The invention relates to dentifrices for children.

Toothpaste is a complex system, which includes abrasive, moisturizing, binders, surface-active components, preservatives, flavors, water and biologically active substances. The ratio of these components determines the properties, purposes, mechanism of action and effectiveness of pastes. The main task when creating new toothpastes is an effective combination of biologically active components with preventive and anti-inflammatory activity, with their consumer properties, namely, a cleansing and deodorizing effect. One of the main tasks in the production of toothpastes is the development of complex-action toothpaste formulations that not only effectively clean the surface of the teeth, have a prophylactic effect on the tissues of the oral cavity and at the same time have a pleasant taste and smell, but also do not contain components that can ambiguously affect only on the organs of the oral cavity, but also with constant use on the human body as a whole, and especially on the children's body, given the likelihood of swallowing the paste.

There are a number of compositions intended for the care of children's teeth. The closest to the claimed prophylactic paste is the Parodontol toothpaste kids 3-7 popsicles containing abrasive - precipitated silica, a thickening agent - sodium carboxymethyl cellulose, a water-retaining substance - sorbitol, an acidity regulator - trisodium phosphate, anticaries, sodium fluoride components for maintaining gum health are sage and echinacea extracts, a sweetener is sodium saccharin, a foaming agent is sodium myristoyl sarcosinate and sodium methyl cocoyl taurate, and romatic composition and water.

Considering that a child after 2 years old can already brush his teeth independently, the urgent issue is to increase the cleansing ability of toothpaste, which would provide an increased effect of cleaning and polishing teeth at the same time, without harming the tooth surface.

The aim of the inventors was the creation of children's toothpaste with a soft cleansing system of increased efficiency, specially designed for children who have not yet learned to hold a toothbrush in their hands and thoroughly brush their teeth. But at the same time, this toothpaste should not cause harm to the enamel of milk teeth and carefully take care of the health of the entire oral cavity. It should also be safe in case of accidental ingestion, since not all children under six years old can rinse their mouth after brushing their teeth.

This goal is achieved by adding a number of components (see Appendix 1) - more modern technological products with improved consumer characteristics.

This composition combines cleansing components (a combination of two types of silicon dioxide), substances that strengthen tooth enamel (sodium fluoride in the amount allowed for children), components that effectively care for gums (complex preparation Polyplant baby care) and ultra-soft surface-active a substance that creates the optimal level of foam for children when brushing their teeth, as well as sodium carboxymethyl cellulose and sodium benzoate, auxiliary components, sorbitol and / and are used as water-retaining substances whether glycerin in the following ratios of components, wt.%:

Finely divided synthetic amorphous silica 14.00-25.00 Finely divided synthetic amorphous silica to enhance cleansing abilities with particles of 1-6 microns 1.00-3.00 Sorbitol / Glycerin 15.00-36.00 Sodium - Carboxymethyl Cellulose 0.80-1.70 Sodium benzoate 0.15-0.50 Titanium dioxide 0.20-0.40 Sodium Myristoyl Sacrosinate and Sodium 0.10-3.00 methyl cocoyl taurate (in terms of 100%) Sodium saccharin 0.02-0.30 Trisodium Phosphate 0.10-1.00 Complex drug Polyplant baby care 0.10-0.60 Carbomer 0.10-0.50 Trilon B 0.001-0.30 Aromatic composition 0.10-0.38 Sodium Fluoride 0,070-0,090 Water up to 100

As an abrasive material, synthetic finely dispersed amorphous silicon dioxide is used, which is due to its high cleaning and polishing effect. Due to its special structure, the product has low abrasiveness and high cleansing ability, specially designed for use in children's toothpastes.

Also, silicon dioxide is an additional, in addition to sodium carboxymethyl cellulose, thickener mixture.

In addition, special silica was added to the formulation to enhance the cleaning ability with a particle size of 1-6 microns, obtained using the latest technology, which allows to achieve a very dense distribution of particles, while providing increased tooth cleaning during the same brushing time. The smallest particle size polishes perfectly without scratches.

To compare the abrasive and polishing properties, we studied samples of children's toothpastes (prototype toothpaste "Parodontol" kids 3-7 popsicles and the claimed composition for treating teeth) in a specially equipped laboratory. The results of the experiment showed that the cleaning ability for the same time up to 2 times higher in the claimed composition than in the prototype.

A graphic image of a profile taken during profilometry is called a profilogram. The information obtained during the processing of profilograms allows you to make a qualitative and quantitative assessment of the roughness of the studied surfaces. In fig. 1, a comparative assessment of profilometry using a plastic plate of the two toothpastes studied in this patent was performed (Sample 1 - the claimed composition for treating teeth, Sample 2 - prototype toothpaste "Parodontol" kids 3-7 popsicles).

As a result of the study, a decrease in the “scratching” effect of the claimed composition for treating children's teeth was revealed compared with the prototype.

Sodium fluoride is used in the toothpaste formulation for an effective anti-caries effect. The main anti-caries effect of the fluoride ingredients of toothpastes is to reduce the permeability of enamel due to the formation of a surface protective layer on the tooth. This layer consists of calcium fluoride, which is also called “labile fluoride”, in contrast to “stable fluoride”, which settles firmly in the solid substance of the tooth. Labile fluoride continuously releases fluoride ions, and this increases until the pH value in the surface layers of carious enamel damage is normalized [2].

In order to achieve a preservative effect, sodium benzoate is used.

To give the toothpaste a bright white color in the inventive composition, titanium dioxide is used, which is better than other known substances for the intended purpose.

Carbomer is a polymer that is used to seal and stabilize an emulsion.

As plant additives, the modern complex preparation Polyplant baby care was used, containing 4 plant extracts with known preventive properties (extracts of calendula, chamomile, mimosa and aromatic violet) and D-panthenol. The content of D-panthenol allows you to strengthen the anti-inflammatory, regenerative and wound healing properties of herbal extracts. [2], [3], [4].

The formula of the claimed composition is designed to minimize the risk of allergic reactions, which is caused by a certain concentration of aromatic composition in the composition of the toothpaste.

The ingredients in this composition are selected taking into account the fact that children can swallow a small portion of toothpaste during brushing.

The compositions of preventive toothpaste for children for several examples are shown in table 1.

The inventive toothpaste is prepared as follows:

components in a prescription quantity are loaded into the stirred reactor: first glycerol and / or sorbitol, water, then sodium carboxymethyl cellulose, titanium dioxide, trilon B, sodium benzoate, trisodium phosphate, sodium saccharin, carbomer, sodium fluoride, and also the additive complex preparation Polyplant baby care, the reactor is sealed. After mixing, two types of silicon dioxide are added to the resulting mixture: synthetic finely dispersed amorphous silica and synthetic finely dispersed amorphous silica to enhance the cleaning ability with particles of 1-6 microns. The mass is homogenized, dispersed, evacuated and the aromatic composition, sodium myristoyl sacrosinate and sodium methyl cocoyl taurate are added. After pumping the resulting composition into the hopper of the tube filling machine, toothpaste is packaged in tubes.

The quality of the toothpaste must comply with the requirements of TP TS 009/2011 and GOST 7983-99.

In laboratory and semi-industrial conditions, studies were conducted that showed that going beyond the stated amounts of the components used in the direction of reduction will not allow you to get a toothpaste with the desired properties, and going beyond the claimed amounts of the components used in the direction of increasing concentrations leads to a deterioration in the consumer properties of the proposed composition.

Due to the optimal selection of components, a toothpaste tape is created that has high consumer properties: monolithic, plastic and well cut off.

The inventive composition was tested at the Central Research Institute of Dentistry and Oral and Maxillofacial Surgery TsNNIS and ChLH.

Tests showed the absence of a general toxic, irritating and sensitizing effect.

The test results of the claimed toothpaste for microbial purity showed a complete absence of bacteria, yeast and molds.

Literature

1. Dentistry for everyone. International Dental Review, A61K 7/16, 1998.

2. "Toothpastes." S.B. Ulitovsky. Man Publishing House, St. Petersburg, 2001

3. "Medicinal plants and beekeeping products used in dentistry." N.V. Kuryakina, O.A. Alekseeva, T.A. Tretyakova, V.G. Makarova. Medical Book Publishing House, 2000

4. "Medicines in dentistry." L.N. Maksimovskaya, P.I. Roshchina, Medicine Publishing House, 2000

Claims (2)

Preventive composition for treating children's teeth, containing synthetic finely dispersed amorphous silicon dioxide, synthetic finely dispersed amorphous silicon dioxide with particles of 1-6 microns, sorbitol / glycerin, sodium carboxymethyl cellulose, sodium benzoate, sodium myristoyl sarcosinate, sodium trisodium sulfate, sodium tri-sodium sulfate Polyplant baby containing plant extracts: calendula, chamomile, mimosa and fragrant violets and D-panthenol, carbomer, sodium fluoride, trilon B, aromatic composition, dye - titanium dioxide and water in the following ratios of components, wt.%: Finely dispersed synthetic amorphous silicon dioxide 15.00-25.00 Finely divided synthetic amorphous silicon dioxide with particles of 1-6 microns 1.00-3.00 Sorbitol / Glycerin 15.00 - 36.00 Sodium carboxymethyl cellulose 0.80 - 1.70 Sodium benzoate 0.15 - 0.50 Sodium myristoyl sarcosinate and sodium methyl cocoyl taurate 0.10 - 3.00 Sodium saccharin 0.02 - 0.30 Trisodium Phosphate 0.01 - 1.00 Complex drug Polyplant baby 0.10 - 0.60 Carbomer 0.10 - 0.50 Sodium fluoride 0.07 - 0.09 Trilon B 0.001-0.30 Aromatic composition 0.10 - 0.38 Dye - titanium dioxide 0.2 - 0.4 Water up to 100

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