CN106619187A - Composition for preventing dental calculus and application - Google Patents
Composition for preventing dental calculus and application Download PDFInfo
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- CN106619187A CN106619187A CN201710054789.2A CN201710054789A CN106619187A CN 106619187 A CN106619187 A CN 106619187A CN 201710054789 A CN201710054789 A CN 201710054789A CN 106619187 A CN106619187 A CN 106619187A
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- dental calculus
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- phosphate
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
- A61K8/24—Phosphorous; Compounds thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
- A61K8/20—Halogens; Compounds thereof
- A61K8/21—Fluorides; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/36—Carboxylic acids; Salts or anhydrides thereof
- A61K8/365—Hydroxycarboxylic acids; Ketocarboxylic acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/55—Phosphorus compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/64—Proteins; Peptides; Derivatives or degradation products thereof
- A61K8/66—Enzymes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/81—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds obtained by reactions involving only carbon-to-carbon unsaturated bonds
- A61K8/8164—Compositions of homopolymers or copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and at least one being terminated by a carboxyl radical, and containing at least one other carboxyl radical in the molecule, or of salts, anhydrides, esters, amides, imides or nitriles thereof; Compositions of derivatives of such polymers, e.g. poly (methyl vinyl ether-co-maleic anhydride)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q11/00—Preparations for care of the teeth, of the oral cavity or of dentures; Dentifrices, e.g. toothpastes; Mouth rinses
Abstract
The invention discloses a composition for preventing and application. The composition consists of the following components in parts by weight: 0.5 to 4 parts of phosphate, 0.05 to 0.3 parts of fluoride, 0.1 to 1.5 parts of PVM/MA copolymer, 0.3 to 1.5 parts of zinc citrate, 0.5 to 1.5 parts of sodium phytate and 0.01 to 0.2 part of alpha-dextranase. The composition disclosed by the invention can safely and effectively inhibit the generation of the dental calculus on the premise of protecting tooth health and maintain the health and attractiveness of teeth. The composition disclosed by the invention is applied to an oral cavity care product, can effectively prevent the formation of the dental calculus, and maintain oral cavity health.
Description
Technical field
The present invention relates to oral care techniques, and in particular to it is a kind of can effectively pre- dental calculus preventing composition and its application.
Background technology
Calculus dentalis is to cause the main local factor of periodontal disease, and is widely present in population of China.Calculus dentalis is main
It is the result of bacterial plaque mineralising, mineral matter mainly accumulates lenticular calcium phosphate group by different densities, different shape and different surfaces
Into.According to typical dental calculus constituent analysis, the main component in its inorganic matter is calcium phosphate 75.97%, magnesium phosphate 3.77%, calcium carbonate
3.17%, organic matter and moisture account for 17.09%.
At present the method for cleaning oral cavity calculus dentalis is periodically to arrive dental professional clinic to carry out mechanical removal, but because expensive
And the factor such as consumption habit is difficult popularization.Therefore, removed by non-model control cleaning agent-chemicals and suppress calculus dentalis always
It is interesting issue.At present, the research of the chemicals for suppressing calculus dentalis to be formed focuses mostly on phosphate, zinc salt.
Compared with the method that frictional property cleans tartar, calculus dentalis more safely, effectively is removed using chemicals, always
With important researching value.Patent CN101330900A discloses the oral care composition comprising zinc and phytic acid,
Prevent and control some oral conditions.Patent CN101690699A discloses a kind of teeth-cleaning whitening toothpaste composition, comprising phytic acid
Salt, pyrophosphate, nitrate and mono-fluor phosphate, by the compounding of each component, synergy functions of whitening teeth.Calcium phosphate is from saliva
In to be precipitated out be calcification balance based in oral cavity.The same dentine of phosphate material, enamel and calculus dentalis have very strong
Key and power, are the removal effect for improving dental surface calculus dentalis, and prior art generally adopts single or compounded combination high-load
Calculus dentalis crystal growth inhibitor, but its remove calculus dentalis effect it is also to be further improved.Simultaneously, although in the work of people
Because normal Physiological effect will not cause enamel decalcification in body tissue, but the phosphate anion presence of high-load makes tooth demineralization
Risk.In addition, for other calculus dentalis inhibitor such as zinc citrates and sodium phytate, high-load zinc citrate can cause in formula
The problem that mouthfeel is bad and system stability is poor.Sodium phytate is applied in toothpaste system, need to consider its compatibility, and sodium phytate is used
Measure that little effect is bad, high-load sodium phytate is excessive to oral cavity mucosa irritation in formula and can cause the unstable problem of system.
The content of the invention
The purpose of the present invention is for the deficiencies in the prior art, there is provided a kind of combination for being capable of safe and effective pre- dental calculus preventing
Thing.
It is a further object to provide the composition of above-mentioned pre- dental calculus preventing is in oral care product is prepared
Using.
The above-mentioned purpose of the present invention is achieved by following scheme：
A kind of composition of pre- dental calculus preventing, the formula of said composition is grouped into by each group of following parts by weight：
The formula of the composition of above-mentioned pre- dental calculus preventing, is preferably grouped into by each group of following parts by weight：
In the composite formula of above-mentioned pre- dental calculus preventing, phosphate is in pyrophosphate, polyphosphate or metaphosphate
Any one or two or more arbitrary proportion mixing；The phosphate is preferably tetrapotassium pyrophosphate, pyrophosphoric acid four
The mixing of any one or two or more arbitrary proportion in sodium, sodium tripolyphosphate or calgon；The phosphoric acid
Salt is more preferably the mixture of tetrapotassium pyrophosphate and sodium tripolyphosphate, tetrapotassium pyrophosphate and sodium tripolyphosphate in the mixture
Weight ratio be tetrapotassium pyrophosphate：Sodium tripolyphosphate=1:4～2:1, the proportion can effectively ensure that tetrapotassium pyrophosphate and three
Polyphosphate sodium plays to greatest extent synergy, it is ensured that the stability of formula, and can reduces cost.
The present inventor has found under study for action, and using fluoride and Gantrez AN-119 phosphatase in oral cavity can be effectively suppressed
Activity, so as to extending phosphate local concentration in the oral cavity, extending its release or the time spread, during formula is improve then
Phosphatic pre- dental calculus preventing effect, having reached strengthens the purpose of calculus dentalis effect；The Gantrez AN-119 is vinyl first
The abbreviation of ether and copolymer-maleic anhydride.
In the composite formula of above-mentioned pre- dental calculus preventing, fluoride is appointing in sodium fluoride, ammonium fluoride or sodium monofluorophosphate
Meaning is a kind of；The fluoride is preferably sodium fluoride.
Biological enzyme formulation can suppress in the oral cavity the breeding of harmful bacteria in oral cavity, eliminate the bacterial plaque of dental surface, prevent
The formation of tartar.The present inventor's research finds that the activity of biology enzyme is very big by the composition influence of toothpaste, keeps within a certain period of time
The stability of higher activity or product it is critical that, so the selection of biological enzyme formulation must take into and composite formula
The collocation of other compositions.Therefore, the present inventor selects α-dextranase other components of arranging in pairs or groups to form this after research
Bright composite formula, is not only able to keep the high activity of α-dextranase, and does not affect the efficacy exertion of other components.
α-the dextranase is capable of achieving the present invention using commercially available prod.
The composition of above-mentioned pre- dental calculus preventing can arrange in pairs or groups acceptable carrier component system on oral cavity well-known in the art
For into oral care product；The carrier component is surfactant, wetting agent, thickener, spices, chelating agent, preservative, rubs
Liniment or sweetener etc.；The oral care product is the common dosage forms such as toothpaste, mouthwash, tooth powder or mouthwass.
The composition of above-mentioned pre- dental calculus preventing when other carrier components of arranging in pairs or groups prepare oral care product, tie by the prevention tooth
The consumption of stone composition is 1.5～8%, preferably the 4～6% of oral care product gross weight.
Compared with prior art, the present invention has the advantages that：
1. the present invention is by calculus dentalis inhibitor phosphate salt material, fluoride, Gantrez AN-119, zinc citrate, sodium phytate
It is combined with α-dextranase, and by optimizing each component consumption so that each component realizes to greatest extent association in formula
Same-action, so as to safely and effectively suppress the generation of calculus dentalis on the premise of dental health is kept, keeps dental health attractive in appearance；
2. phosphate is easily decomposed in the oral cavity by phosphatase, and fluoride and PVM/MA in present composition formula are common
Polymers can respectively suppress neutral in the oral cavity and acid, activity of alkaline phosphatase, prevent phosphate by phosphoric acid enzyme hydrolysis, keep mouth
Sufficient concentrations of complex anion in chamber, so as to improve the anti-calculus dentalis effect in the oral cavity of said composition；Additionally, of the invention
Consumption of the phosphate in formula preferably below 3%, it is same suppress calculus dentalis to be formed by controlling phosphatic consumption
When, moreover it is possible to avoid phosphate anion complexing tooth in calcium ion so as to injure tooth；
3. the present inventor's research finds zinc citrate as a kind of anti-calculus dentalis composition, and its mouthfeel has certain bitterness sense
And solubility is less, and the tetrapotassium pyrophosphate in the present composition helps the mouthfeel for alleviating zinc citrate, and PVM/MA copolymerization
Thing is using the bioadhesive and slow-release capability of itself, it is possible to increase the solubility of zinc citrate simultaneously extends its effect in the oral cavity
Time；
4. the phytate in the composition of pre- dental calculus preventing of the invention, by with saliva and tartar composition in metal ion
Such as calcium, magnesium ion complexing, it is to avoid or mitigate the situation for forming calculus dentalis；
5. the zinc citrate in the composition of pre- dental calculus preventing of the invention can also effectively suppress halitosis pathogenic bacteria, remove not
Good implication, phosphate improves the stability of product, sodium phytate can with the complexing of the color stain of dental surface generate water soluble ingredient so as to
The purpose of tooth-whitening is reached, enzyme preparation has anticariogenic effect by decomposing the polysaccharose substance that cariogenic bacteria is produced, and is fluorinated
Thing is applied in oral care implement, can improve the firm tooth of tooth acid resistance, with significant anti-caries effect；
6. the composition of pre- dental calculus preventing of the invention, can effectively ensure that biology enzyme is gone back during toothpaste is placed 1 year in formula
Enzymatic activity more than 90%, toothpaste is kept to go tartar effect up to more than 30%.
Specific embodiment
The present invention is further described through with reference to specific embodiment, but specific embodiment is not appointed to the present invention
What is limited.
Embodiment 1
A kind of toothpaste containing pre- dental calculus preventing composition, the formula of the toothpaste is grouped by each group of following parts by weight
Into：
0.5 part of tetrapotassium pyrophosphate, 0.5 part of sodium tripolyphosphate, 0.24 part of sodium fluoride, 0.3 part of Gantrez AN-119, citric acid
0.3 part of zinc, 0.5 part of sodium phytate, 0.01 part of α-dextranase, 20 parts of sorbierite, 3 parts of glycerine, 3 parts of PEG-8, carbonic acid Ca45
Part, 3 parts of silica, 4 parts of Cocoamidopropyl betaine, 4 parts of sodium lauroyl sarcosine, 0.5 part of xanthans, carragheen 0.4
Part, 0.25 part of saccharin sodium, 0.3 part of Sodium Benzoate, 1 part of essence, balance of deionized water.
Embodiment 2
A kind of toothpaste containing pre- dental calculus preventing composition, the formula of the toothpaste is grouped by each group of following parts by weight
Into：
0 part of tetrapotassium pyrophosphate, 2 parts of sodium tripolyphosphate, 0.24 part of sodium fluoride, 0.5 part of Gantrez AN-119, zinc citrate
0.5 part, 1.0 parts of sodium phytate, 0.01 part of α-dextranase, 20 parts of sorbierite, 5 parts of PEG-8,25 parts of silica, cocounut oil acyl
1 part of amine CAB, 2 parts of laruyl alcohol sodium sulfovinate, 0.5 part of xanthans, 0.4 part of carragheen, 0.25 part of saccharin sodium, benzoic acid
0.3 part of sodium, 1 part of essence, balance of deionized water.
Embodiment 3
A kind of toothpaste containing pre- dental calculus preventing composition, the formula of the toothpaste is grouped by each group of following parts by weight
Into：
2.0 parts of tetrapotassium pyrophosphate, 0 part of sodium tripolyphosphate, 0.24 part of sodium fluoride, 0.5 part of Gantrez AN-119, zinc citrate
1.0 parts, 0.5 part of sodium phytate, 0.05 part of α-dextranase, 20 parts of sorbierite, 5 parts of PEG-8,25 parts of silica, cocounut oil acyl
1 part of amine CAB, 2 parts of laruyl alcohol sodium sulfovinate, 0.5 part of xanthans, 0.4 part of carragheen, 0.25 part of saccharin sodium, benzoic acid
0.3 part of sodium, 1 part of essence, balance of deionized water.
Embodiment 4
A kind of toothpaste containing pre- dental calculus preventing composition, the formula of the toothpaste is grouped by each group of following parts by weight
Into：
1.0 parts of tetrapotassium pyrophosphate, 1.5 parts of sodium tripolyphosphate, 0.24 part of sodium fluoride, 0.5 part of Gantrez AN-119, citric acid
0.5 part of zinc, 1.0 parts of sodium phytate, 0.01 part of α-dextranase, 20 parts of sorbierite, 5 parts of PEG-8,25 parts of silica, cocounut oil
1 part of amido propyl betaine, 2 parts of laruyl alcohol sodium sulfovinate, 0.5 part of xanthans, 0.4 part of carragheen, 0.25 part of saccharin sodium, benzene first
0.3 part of sour sodium, 1 part of essence, balance of deionized water.
Embodiment 5
A kind of toothpaste containing pre- dental calculus preventing composition, the formula of the toothpaste is grouped by each group of following parts by weight
Into：
1.5 parts of tetrapotassium pyrophosphate, 1.0 parts of sodium tripolyphosphate, 0.24 part of sodium fluoride, 0.5 part of Gantrez AN-119, citric acid
0.5 part of zinc, 1.0 parts of sodium phytate, 0.05 part of α-dextranase, 20 parts of sorbierite, 5 parts of PEG-8,25 parts of silica, cocounut oil
1 part of amido propyl betaine, 2 parts of laruyl alcohol sodium sulfovinate, 0.5 part of xanthans, 0.4 part of carragheen, 0.25 part of saccharin sodium, benzene first
0.3 part of sour sodium, 1 part of essence, balance of deionized water.
Embodiment 6
A kind of toothpaste containing pre- dental calculus preventing composition, the formula of the toothpaste is grouped by each group of following parts by weight
Into：
1.5 parts of tetrapotassium pyrophosphate, 1.5 parts of sodium tripolyphosphate, 0.24 part of sodium fluoride, 1.0 parts of Gantrez AN-119, citric acid
0.5 part of zinc, 0.5 part of sodium phytate, 0.05 part of α-dextranase, 20 parts of sorbierite, 5 parts of PEG-8,25 parts of silica, cocounut oil
1 part of amido propyl betaine, 2 parts of laruyl alcohol sodium sulfovinate, 0.5 part of xanthans, 0.4 part of carragheen, 0.25 part of saccharin sodium, benzene first
0.3 part of sour sodium, 1 part of essence, balance of deionized water.
The external anti-calculus dentalis experiment of embodiment 7
The bacterial plaque growth of the present embodiment and mineralization model are that bacterial plaque is cultivated from people's saliva, are then made in mineralized liquid
Its mineralising, bacterial plaque calcification level of the measure after toothpaste process, so as to verify that toothpaste suppresses the effect of calculus dentalis growth.
The dentifrice slurry that the formulation of tooth-paste preparation of embodiment 1-6 is respectively adopted is processed mineralising bacterial plaque, once a day, often
Secondary 60s, after continuing 10 days, the potassium hydroxide solution for adding 4mL 0.9mol/L vibrates 2 days, adds the 1mol/L chlorinations of 4mL
Hydrogen：The vibration of 1mo l/L acetums mixes constant temperature and overnight parses bacterial plaque, is subsequently adding the hydroxide of 4mL 0.9mol/L
After potassium solution, the calcium ion content in the mixed liquor is analyzed, so as to the anti-calculus dentalis effect of the toothpaste for judging different activities composition.
If calcium ion content is less in mixed liquor, the calculus dentalis amount for being formed is less, further relates to the tooth that the group is used
Cream has stronger anti-calculus dentalis effect.
Using calcium content such as table 1 in the bacterial plaque after the process of embodiment 1-6 toothpaste, by the measure to calcium content in bacterial plaque,
The toothpaste containing the pre- dental calculus preventing composition of the different amounts present invention is apparent from, it has different anti-calculus dentalis effects.
The content of calcium ion in bacterial plaque after the different embodiment toothpaste process of table 1
The composition levels of pre- dental calculus preventing are 2.35% in the toothpaste of embodiment 1, pre- dental calculus preventing in the toothpaste of embodiment 2
Composition levels are 4.25%, and the composition levels of pre- dental calculus preventing are 4.29% in the toothpaste of embodiment 3, in the toothpaste of embodiment 4
The composition levels of pre- dental calculus preventing are 4.75%, and the composition levels of pre- dental calculus preventing are 4.79% in the toothpaste of embodiment 5, real
The composition levels for applying pre- dental calculus preventing in the toothpaste of example 6 are 5.29%；The percentage is that the composition of pre- dental calculus preventing accounts for tooth
The percentage of cream gross weight.
The toothpaste of embodiment 1 is can be seen that from the data of table 1 and process the bacterial plaque after mineralising, put down in its bacterial plaque for parsing
Calcium content highest, thus illustrates that the toothpaste of embodiment 1 suppresses the effect of calculus dentalis worst, and with pre- dental calculus preventing in toothpaste
The increase of composition levels, toothpaste suppresses the effect of calculus dentalis to become better and better.
Embodiment 2 be phosphate only with sodium tripolyphosphate, embodiment 3 is phosphate only with tetrapotassium pyrophosphate, is implemented
The phosphate of example 4,5 and 6 then adopts the combination of tetrapotassium pyrophosphate and sodium tripolyphosphate, can be clearly seen that from data result,
The suppression calculus dentalis effect of embodiment 2 and 3 is significantly worse than embodiment 4,5 and 6, illustrates tetrapotassium pyrophosphate and sodium tripolyphosphate collocation
Using the preventive effect to calculus dentalis better than exclusive use.
Can be seen that as pre- dental calculus preventing composition of the invention is in toothpaste from the Data Comparison result of embodiment 4,5 and 6
In content increase, the effect of the pre- dental calculus preventing of toothpaste also substantially increases.
The announcement and teaching of book according to the above description, those skilled in the art in the invention can also be to above-mentioned embodiment party
Formula is changed and changed.Therefore, specific embodiment disclosed and described above is the invention is not limited in, to the present invention's
Some modifications and changes should also be as falling in the scope of the claims of the present invention.Although additionally, used in this specification
Some specific terms, but these terms are merely for convenience of description, do not constitute any restriction to the present invention.
Claims (10)
1. a kind of composition of pre- dental calculus preventing, it is characterised in that the formula of said composition is by each component of following parts by weight
Composition：
2. the composition of pre- dental calculus preventing according to claim 1, it is characterised in that the formula of said composition is by weighing as follows
The each group of amount number is grouped into：
3. the composition of pre- dental calculus preventing according to claim 1 or claim 2, it is characterised in that the phosphate be pyrophosphate,
The mixing of any one or two or more arbitrary proportion in polyphosphate or metaphosphate.
4. the composition of pre- dental calculus preventing according to claim 3, it is characterised in that the phosphate is tetrapotassium pyrophosphate, Jiao
The mixing of any one or two or more arbitrary proportion in tetrasodium phosphate, sodium tripolyphosphate or calgon.
5. the composition of pre- dental calculus preventing according to claim 4, it is characterised in that the phosphate be tetrapotassium pyrophosphate and
The mixture of sodium tripolyphosphate, the weight ratio of tetrapotassium pyrophosphate and sodium tripolyphosphate is 1 in the mixture：4～2：1.
6. the composition of pre- dental calculus preventing according to claim 1 or claim 2, it is characterised in that the fluoride is sodium fluoride, fluorine
Change ammonium or sodium monofluorophosphate.
7. the composition of pre- dental calculus preventing according to claim 6, it is characterised in that the fluoride is sodium fluoride.
8. application of the composition of pre- dental calculus preventing in oral care product is prepared described in claim 1 or 2.
9. application according to claim 8, it is characterised in that the consumption of the composition of the pre- dental calculus preventing is oral cavity shield
The 1.5～8% of reason product gross weight.
10. application according to claim 9, it is characterised in that the consumption of the composition of the pre- dental calculus preventing is oral cavity shield
The 4～6% of reason product gross weight.
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| CN201710054789.2A CN106619187B (en) | 2017-01-24 | 2017-01-24 | A kind of composition of pre- dental calculus preventing and application |
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| Application Number | Priority Date | Filing Date | Title |
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| CN201710054789.2A CN106619187B (en) | 2017-01-24 | 2017-01-24 | A kind of composition of pre- dental calculus preventing and application |
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107625659A (en) * | 2017-09-04 | 2018-01-26 | 美晨集团股份有限公司 | A kind of whitening toothpaste and preparation method thereof |
| CN111803401A (en) * | 2020-08-03 | 2020-10-23 | 广州佩奇生物科技有限公司 | Oral care composition, tooth powder, toothpaste and mouthwash |
| CN115337248A (en) * | 2022-08-01 | 2022-11-15 | 河南慈仁生物科技研究院有限公司 | Formula and preparation method of toothpaste for remineralizing enamel |
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Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107625659A (en) * | 2017-09-04 | 2018-01-26 | 美晨集团股份有限公司 | A kind of whitening toothpaste and preparation method thereof |
| CN107625659B (en) * | 2017-09-04 | 2020-06-26 | 美晨集团股份有限公司 | Whitening toothpaste and preparation method thereof |
| CN111803401A (en) * | 2020-08-03 | 2020-10-23 | 广州佩奇生物科技有限公司 | Oral care composition, tooth powder, toothpaste and mouthwash |
| CN115337248A (en) * | 2022-08-01 | 2022-11-15 | 河南慈仁生物科技研究院有限公司 | Formula and preparation method of toothpaste for remineralizing enamel |
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| Publication number | Publication date |
|---|---|
| CN106619187B (en) | 2019-07-16 |
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