CN102512335A - Whitening toothpaste suitable for evening and combined whitening toothpaste suitable for morning and evening - Google Patents
Whitening toothpaste suitable for evening and combined whitening toothpaste suitable for morning and evening Download PDFInfo
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- CN102512335A CN102512335A CN2012100058535A CN201210005853A CN102512335A CN 102512335 A CN102512335 A CN 102512335A CN 2012100058535 A CN2012100058535 A CN 2012100058535A CN 201210005853 A CN201210005853 A CN 201210005853A CN 102512335 A CN102512335 A CN 102512335A
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- whitening toothpaste
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- 239000000606 toothpaste Substances 0.000 title claims abstract description 79
- 229940034610 toothpaste Drugs 0.000 title claims abstract description 78
- 230000002087 whitening effect Effects 0.000 title claims abstract description 52
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 claims abstract description 38
- VTYYLEPIZMXCLO-UHFFFAOYSA-L Calcium carbonate Chemical compound [Ca+2].[O-]C([O-])=O VTYYLEPIZMXCLO-UHFFFAOYSA-L 0.000 claims abstract description 32
- 239000000377 silicon dioxide Substances 0.000 claims abstract description 19
- 235000012239 silicon dioxide Nutrition 0.000 claims abstract description 18
- -1 poly(vinyl methylether) Polymers 0.000 claims abstract description 17
- 229910000019 calcium carbonate Inorganic materials 0.000 claims abstract description 16
- IMQLKJBTEOYOSI-GPIVLXJGSA-N Inositol-hexakisphosphate Chemical compound OP(O)(=O)O[C@H]1[C@H](OP(O)(O)=O)[C@@H](OP(O)(O)=O)[C@H](OP(O)(O)=O)[C@H](OP(O)(O)=O)[C@@H]1OP(O)(O)=O IMQLKJBTEOYOSI-GPIVLXJGSA-N 0.000 claims abstract description 15
- 235000002949 phytic acid Nutrition 0.000 claims abstract description 15
- 239000002562 thickening agent Substances 0.000 claims abstract description 15
- WGIWBXUNRXCYRA-UHFFFAOYSA-H trizinc;2-hydroxypropane-1,2,3-tricarboxylate Chemical compound [Zn+2].[Zn+2].[Zn+2].[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O.[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O WGIWBXUNRXCYRA-UHFFFAOYSA-H 0.000 claims abstract description 15
- 239000011746 zinc citrate Substances 0.000 claims abstract description 15
- 229940068475 zinc citrate Drugs 0.000 claims abstract description 15
- 235000006076 zinc citrate Nutrition 0.000 claims abstract description 15
- XPPKVPWEQAFLFU-UHFFFAOYSA-J diphosphate(4-) Chemical compound [O-]P([O-])(=O)OP([O-])([O-])=O XPPKVPWEQAFLFU-UHFFFAOYSA-J 0.000 claims abstract description 13
- 235000011180 diphosphates Nutrition 0.000 claims abstract description 13
- 230000008901 benefit Effects 0.000 claims description 32
- 230000009286 beneficial effect Effects 0.000 claims description 21
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 claims description 15
- 239000000080 wetting agent Substances 0.000 claims description 14
- 239000000203 mixture Substances 0.000 claims description 13
- 239000002994 raw material Substances 0.000 claims description 12
- 239000004094 surface-active agent Substances 0.000 claims description 10
- XJRBAMWJDBPFIM-UHFFFAOYSA-N methyl vinyl ether Chemical compound COC=C XJRBAMWJDBPFIM-UHFFFAOYSA-N 0.000 claims description 9
- DNIAPMSPPWPWGF-UHFFFAOYSA-N Propylene glycol Chemical compound CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 claims description 6
- FBPFZTCFMRRESA-FSIIMWSLSA-N D-Glucitol Natural products OC[C@H](O)[C@H](O)[C@@H](O)[C@H](O)CO FBPFZTCFMRRESA-FSIIMWSLSA-N 0.000 claims description 5
- FBPFZTCFMRRESA-JGWLITMVSA-N D-glucitol Chemical compound OC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-JGWLITMVSA-N 0.000 claims description 5
- 239000002202 Polyethylene glycol Substances 0.000 claims description 5
- 239000001768 carboxy methyl cellulose Substances 0.000 claims description 5
- 229920001223 polyethylene glycol Polymers 0.000 claims description 5
- 239000000600 sorbitol Substances 0.000 claims description 5
- NIXOWILDQLNWCW-UHFFFAOYSA-N Acrylic acid Chemical compound OC(=O)C=C NIXOWILDQLNWCW-UHFFFAOYSA-N 0.000 claims description 2
- 229920002134 Carboxymethyl cellulose Polymers 0.000 claims description 2
- ZGTMUACCHSMWAC-UHFFFAOYSA-L EDTA disodium salt (anhydrous) Chemical compound [Na+].[Na+].OC(=O)CN(CC([O-])=O)CCN(CC(O)=O)CC([O-])=O ZGTMUACCHSMWAC-UHFFFAOYSA-L 0.000 claims description 2
- 229920002907 Guar gum Polymers 0.000 claims description 2
- 239000004354 Hydroxyethyl cellulose Substances 0.000 claims description 2
- 229920000663 Hydroxyethyl cellulose Polymers 0.000 claims description 2
- DBMJMQXJHONAFJ-UHFFFAOYSA-M Sodium laurylsulphate Chemical group [Na+].CCCCCCCCCCCCOS([O-])(=O)=O DBMJMQXJHONAFJ-UHFFFAOYSA-M 0.000 claims description 2
- 229920002125 Sokalan® Polymers 0.000 claims description 2
- 229960001631 carbomer Drugs 0.000 claims description 2
- 235000010948 carboxy methyl cellulose Nutrition 0.000 claims description 2
- 239000008112 carboxymethyl-cellulose Substances 0.000 claims description 2
- 229920002678 cellulose Polymers 0.000 claims description 2
- 239000001913 cellulose Substances 0.000 claims description 2
- 235000010980 cellulose Nutrition 0.000 claims description 2
- 239000000665 guar gum Substances 0.000 claims description 2
- 235000010417 guar gum Nutrition 0.000 claims description 2
- 229960002154 guar gum Drugs 0.000 claims description 2
- 235000019447 hydroxyethyl cellulose Nutrition 0.000 claims description 2
- 229940071826 hydroxyethyl cellulose Drugs 0.000 claims description 2
- 239000001866 hydroxypropyl methyl cellulose Substances 0.000 claims description 2
- 229920003088 hydroxypropyl methyl cellulose Polymers 0.000 claims description 2
- 235000010979 hydroxypropyl methyl cellulose Nutrition 0.000 claims description 2
- UFVKGYZPFZQRLF-UHFFFAOYSA-N hydroxypropyl methyl cellulose Chemical compound OC1C(O)C(OC)OC(CO)C1OC1C(O)C(O)C(OC2C(C(O)C(OC3C(C(O)C(O)C(CO)O3)O)C(CO)O2)O)C(CO)O1 UFVKGYZPFZQRLF-UHFFFAOYSA-N 0.000 claims description 2
- 239000000230 xanthan gum Substances 0.000 claims description 2
- 229920001285 xanthan gum Polymers 0.000 claims description 2
- 235000010493 xanthan gum Nutrition 0.000 claims description 2
- 229940082509 xanthan gum Drugs 0.000 claims description 2
- 239000004141 Sodium laurylsulphate Substances 0.000 claims 1
- 235000019333 sodium laurylsulphate Nutrition 0.000 claims 1
- 230000000694 effects Effects 0.000 abstract description 10
- 241000894006 Bacteria Species 0.000 abstract description 8
- 239000003795 chemical substances by application Substances 0.000 abstract description 6
- 210000000214 mouth Anatomy 0.000 abstract description 6
- 208000002064 Dental Plaque Diseases 0.000 abstract description 5
- 238000004140 cleaning Methods 0.000 abstract description 5
- 210000003298 dental enamel Anatomy 0.000 abstract description 5
- QCZAWDGAVJMPTA-RNFRBKRXSA-N ClC1=CC=CC(=N1)C1=NC(=NC(=N1)N[C@@H](C(F)(F)F)C)N[C@@H](C(F)(F)F)C Chemical compound ClC1=CC=CC(=N1)C1=NC(=NC(=N1)N[C@@H](C(F)(F)F)C)N[C@@H](C(F)(F)F)C QCZAWDGAVJMPTA-RNFRBKRXSA-N 0.000 abstract description 4
- 230000000844 anti-bacterial effect Effects 0.000 abstract description 4
- 239000002131 composite material Substances 0.000 abstract description 3
- 229920001577 copolymer Polymers 0.000 abstract description 3
- 238000005202 decontamination Methods 0.000 abstract description 2
- 230000003588 decontaminative effect Effects 0.000 abstract description 2
- 229920002432 poly(vinyl methyl ether) polymer Polymers 0.000 abstract 2
- 239000004909 Moisturizer Substances 0.000 abstract 1
- 150000008064 anhydrides Chemical class 0.000 abstract 1
- 230000001333 moisturizer Effects 0.000 abstract 1
- 238000000034 method Methods 0.000 description 7
- 238000005516 engineering process Methods 0.000 description 6
- 239000000049 pigment Substances 0.000 description 6
- 229940048084 pyrophosphate Drugs 0.000 description 6
- FENRSEGZMITUEF-ATTCVCFYSA-E [Na+].[Na+].[Na+].[Na+].[Na+].[Na+].[Na+].[Na+].[Na+].OP(=O)([O-])O[C@@H]1[C@@H](OP(=O)([O-])[O-])[C@H](OP(=O)(O)[O-])[C@H](OP(=O)([O-])[O-])[C@H](OP(=O)(O)[O-])[C@H]1OP(=O)([O-])[O-] Chemical compound [Na+].[Na+].[Na+].[Na+].[Na+].[Na+].[Na+].[Na+].[Na+].OP(=O)([O-])O[C@@H]1[C@@H](OP(=O)([O-])[O-])[C@H](OP(=O)(O)[O-])[C@H](OP(=O)([O-])[O-])[C@H](OP(=O)(O)[O-])[C@H]1OP(=O)([O-])[O-] FENRSEGZMITUEF-ATTCVCFYSA-E 0.000 description 5
- 229940083982 sodium phytate Drugs 0.000 description 5
- 208000006558 Dental Calculus Diseases 0.000 description 4
- 244000269722 Thea sinensis Species 0.000 description 4
- 238000002360 preparation method Methods 0.000 description 4
- FTLYMKDSHNWQKD-UHFFFAOYSA-N (2,4,5-trichlorophenyl)boronic acid Chemical compound OB(O)C1=CC(Cl)=C(Cl)C=C1Cl FTLYMKDSHNWQKD-UHFFFAOYSA-N 0.000 description 3
- 241000208125 Nicotiana Species 0.000 description 3
- 235000002637 Nicotiana tabacum Nutrition 0.000 description 3
- DPXJVFZANSGRMM-UHFFFAOYSA-N acetic acid;2,3,4,5,6-pentahydroxyhexanal;sodium Chemical compound [Na].CC(O)=O.OCC(O)C(O)C(O)C(O)C=O DPXJVFZANSGRMM-UHFFFAOYSA-N 0.000 description 3
- ORILYTVJVMAKLC-UHFFFAOYSA-N adamantane Chemical compound C1C(C2)CC3CC1CC2C3 ORILYTVJVMAKLC-UHFFFAOYSA-N 0.000 description 3
- 229910001573 adamantine Inorganic materials 0.000 description 3
- 230000032683 aging Effects 0.000 description 3
- 239000011575 calcium Substances 0.000 description 3
- 238000001514 detection method Methods 0.000 description 3
- 239000003599 detergent Substances 0.000 description 3
- 239000003292 glue Substances 0.000 description 3
- 238000000227 grinding Methods 0.000 description 3
- 239000013521 mastic Substances 0.000 description 3
- LXCFILQKKLGQFO-UHFFFAOYSA-N methylparaben Chemical compound COC(=O)C1=CC=C(O)C=C1 LXCFILQKKLGQFO-UHFFFAOYSA-N 0.000 description 3
- 238000012856 packing Methods 0.000 description 3
- 239000002245 particle Substances 0.000 description 3
- 230000008569 process Effects 0.000 description 3
- 229940085605 saccharin sodium Drugs 0.000 description 3
- 235000019812 sodium carboxymethyl cellulose Nutrition 0.000 description 3
- 229920001027 sodium carboxymethylcellulose Polymers 0.000 description 3
- VZWGHDYJGOMEKT-UHFFFAOYSA-J sodium pyrophosphate decahydrate Chemical compound O.O.O.O.O.O.O.O.O.O.[Na+].[Na+].[Na+].[Na+].[O-]P([O-])(=O)OP([O-])([O-])=O VZWGHDYJGOMEKT-UHFFFAOYSA-J 0.000 description 3
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 3
- 239000004098 Tetracycline Substances 0.000 description 2
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 description 2
- 235000010216 calcium carbonate Nutrition 0.000 description 2
- 230000008859 change Effects 0.000 description 2
- 150000001875 compounds Chemical class 0.000 description 2
- 210000004268 dentin Anatomy 0.000 description 2
- 238000002474 experimental method Methods 0.000 description 2
- 238000007689 inspection Methods 0.000 description 2
- 238000004519 manufacturing process Methods 0.000 description 2
- 239000001301 oxygen Substances 0.000 description 2
- 229910052760 oxygen Inorganic materials 0.000 description 2
- 229960002180 tetracycline Drugs 0.000 description 2
- 229930101283 tetracycline Natural products 0.000 description 2
- 235000019364 tetracycline Nutrition 0.000 description 2
- 150000003522 tetracyclines Chemical class 0.000 description 2
- PAWALTXRSMCTAC-ODTHDHSBSA-N (2S)-2-[[(2R)-2-[[(2S)-2-[[(2R)-2-[[(2S)-2-[[(2S)-2-[[(2R)-2-[[(2R)-2-[[(2S)-2-[[(2S)-2-[[2-[(2-aminoacetyl)amino]acetyl]amino]propanoyl]amino]-3-hydroxypropanoyl]amino]-3-sulfanylpropanoyl]amino]-3-sulfanylpropanoyl]amino]-4-methylpentanoyl]amino]-3-(4-hydroxyphenyl)propanoyl]amino]-3-sulfanylpropanoyl]amino]-5-(diaminomethylideneamino)pentanoyl]amino]-3-sulfanylpropanoyl]amino]-3-(1H-imidazol-5-yl)propanoic acid Chemical compound CC(C)C[C@H](NC(=O)[C@H](CS)NC(=O)[C@H](CS)NC(=O)[C@H](CO)NC(=O)[C@H](C)NC(=O)CNC(=O)CN)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CS)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CS)C(=O)N[C@@H](Cc1c[nH]cn1)C(O)=O PAWALTXRSMCTAC-ODTHDHSBSA-N 0.000 description 1
- 206010021703 Indifference Diseases 0.000 description 1
- 206010039424 Salivary hypersecretion Diseases 0.000 description 1
- 208000014735 Tooth injury Diseases 0.000 description 1
- 239000002253 acid Substances 0.000 description 1
- 230000001154 acute effect Effects 0.000 description 1
- 150000001450 anions Chemical class 0.000 description 1
- 230000001580 bacterial effect Effects 0.000 description 1
- 230000000721 bacterilogical effect Effects 0.000 description 1
- 230000003385 bacteriostatic effect Effects 0.000 description 1
- 230000003115 biocidal effect Effects 0.000 description 1
- 230000015572 biosynthetic process Effects 0.000 description 1
- 238000004061 bleaching Methods 0.000 description 1
- 229960003563 calcium carbonate Drugs 0.000 description 1
- FUFJGUQYACFECW-UHFFFAOYSA-L calcium hydrogenphosphate Chemical compound [Ca+2].OP([O-])([O-])=O FUFJGUQYACFECW-UHFFFAOYSA-L 0.000 description 1
- 125000002837 carbocyclic group Chemical group 0.000 description 1
- 239000002738 chelating agent Substances 0.000 description 1
- 238000006243 chemical reaction Methods 0.000 description 1
- 235000019504 cigarettes Nutrition 0.000 description 1
- 238000010276 construction Methods 0.000 description 1
- 230000037123 dental health Effects 0.000 description 1
- 230000008021 deposition Effects 0.000 description 1
- 235000019700 dicalcium phosphate Nutrition 0.000 description 1
- 235000005911 diet Nutrition 0.000 description 1
- 230000037213 diet Effects 0.000 description 1
- 239000003651 drinking water Substances 0.000 description 1
- 235000020188 drinking water Nutrition 0.000 description 1
- 239000000686 essence Substances 0.000 description 1
- 230000036541 health Effects 0.000 description 1
- 230000005764 inhibitory process Effects 0.000 description 1
- 229910052500 inorganic mineral Inorganic materials 0.000 description 1
- 150000002500 ions Chemical class 0.000 description 1
- 239000011707 mineral Substances 0.000 description 1
- 235000010755 mineral Nutrition 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 230000032724 odontogenesis Effects 0.000 description 1
- 239000012860 organic pigment Substances 0.000 description 1
- 230000003204 osmotic effect Effects 0.000 description 1
- 150000002978 peroxides Chemical class 0.000 description 1
- 230000000704 physical effect Effects 0.000 description 1
- 230000019612 pigmentation Effects 0.000 description 1
- 239000000843 powder Substances 0.000 description 1
- 238000012545 processing Methods 0.000 description 1
- 238000011084 recovery Methods 0.000 description 1
- 238000006479 redox reaction Methods 0.000 description 1
- 230000008929 regeneration Effects 0.000 description 1
- 238000011069 regeneration method Methods 0.000 description 1
- 208000026451 salivation Diseases 0.000 description 1
- 229960001866 silicon dioxide Drugs 0.000 description 1
- 150000003384 small molecules Chemical group 0.000 description 1
- FQENQNTWSFEDLI-UHFFFAOYSA-J sodium diphosphate Chemical compound [Na+].[Na+].[Na+].[Na+].[O-]P([O-])(=O)OP([O-])([O-])=O FQENQNTWSFEDLI-UHFFFAOYSA-J 0.000 description 1
- 238000007619 statistical method Methods 0.000 description 1
- 235000019818 tetrasodium diphosphate Nutrition 0.000 description 1
- 210000005239 tubule Anatomy 0.000 description 1
- 238000004383 yellowing Methods 0.000 description 1
Landscapes
- Cosmetics (AREA)
Abstract
The invention discloses whitening toothpaste suitable for evening and combined whitening toothpaste suitable for morning and evening. The combined whitening toothpaste suitable for the morning and the evening is composed of whitening toothpaste suitable for morning and the whitening toothpaste suitable for the evening; and the toothpaste suitable for cleaning in the evening comprises a moisturizer, a rubbing agent, a thickening agent, pyrophosphate, phytate, a poly(vinyl methylether)/malaic anhydride copolymer and zinc citrate. According to different oral cavity environments in the morning and the evening, different antibacterial factors are added; and an organic decontamination agent of the phytate is added into the toothpaste suitable for the morning and composite active factors of PVM/MA (Poly(Vinyl Methylether)/Malaic Anhydride) and the zinc citrate are added into the toothpaste suitable for the evening, so as to achieve the effects of simultaneously resisting bacteria, removing dental plaques and whitening at day and night. Meanwhile, silicon dioxide is prepared to replace one part of calcium carbonate, so that the scratches of tooth enamels, caused by the rubbing agent, are reduced while the effects of decontaminating and whitening are achieved.
Description
Technical field
The present invention relates to field of oral care, be specifically related to the oral care composition field.
Background technology
Current society; People more and more is paid close attention to oral hygiene and health, has a mouthful healthy brilliant white tooth to become people gradually and pursues one's goal, and the yellow main source of tooth black tooth is divided into exogenous mottle and endogenous mottle; Exogenous mottle is because dental surface exists various bacteria; They secrete many emplastics, and some mineral in the tea stain in the diet, cigarette stain and the drinking water is adsorbed on these emplastics, makes tooth flavescence or blackening gradually.Endogenous is painted to be formed in the tooth development process, is deposited in the dentin like tetracycline, will make tooth yellowing, brown or lead to be called tetracycline pigmentation teeth.Removing at present the main path that dental plaque reaches whitening effect has three kinds, and one, add the abrasivus of high friction valve.Like, calcium carbonate, calcium hydrogen phosphate, silicon dioxide etc.Two, the active oxygen that uses peroxide to discharge comes bleaching teeth.Three, use strong acid or highly basic to remove dental plaque.Yet life-time service can cause certain influence to dental health.The crystalline particle ultrastructure surface of calcium carbonate has more acute angle can scratch the glaze of tooth aspect abrasivus.Under the situation that guarantees cleaning, possibly reduce the consumption of calcium carbonate unexpectedly; Silicon dioxide is high-end abrasivus; Have certain friction valve property, quality better and on the ultra micro of silicon dioxide crystalline particle surface the aggregated particles for the circular space that is full of honeycomb, to performances such as the tooth injury are little.These silicon dioxide will pass through special processing sometimes, and the abrasive silica of 97195269,97196178 pairs of toothpaste of patent is introduced.Present oral care product can not satisfy because of the morning and evening oral environment different, suppresses the regenerated purpose of different bacterium, can not effectively decompose exogenous spot simultaneously, reduces the mottle surface area and the degree of depth.
Summary of the invention
The technical problem that the present invention solves is according to morning and evening oral environment difference the ordinary toothpaste prescription further to be improved, and is reducing the regeneration that adamantine wearing and tearing suppress gram-positive bacterium and gram negative bacteria simultaneously, reaches the effect of the formation that suppresses dental plaque.The different bacterial contents that cause in the oral cavity of the oral cavity pH on evening and daytime, oxygen content, salivation amount are different in human oral cavity, and requiring people is to select suitable toothpaste according to day and night what use toothpaste.The present invention is according to the different benefit beneficial late whitening toothpastes early of releasing of environment at night on daytime.Toothpaste of the present invention is selected high-end abrasivus silicon dioxide instead of part calcium carbonate for use, thereby the consumption that reduces calcium carbonate reduces adamantine wearing and tearing and reaches certain friction effect.The tartar main component is the carboxyl calcium pyrophosphate, in toothpaste, adds inorganic detergent, and the anion in the inorganic detergent is Ca
2+, Mg
2+Deng chelating agent, changed into stable soluble complexes to these ions in the tartar.
The NFD active factors that in the late toothpaste of benefit, adds PVM/MA copolymer and the compound composition of zinc citrate.Can get in enamel and the dentin by strong osmotic; Pass through into tooth micropore shape structure rapidly; Combine with the pigment molecular in adamantine layer and the dentinal tubule, redox reaction or complex reaction take place, organic pigment is become hydrophilic non-pigment small molecule structure by the carbocyclic ring construction recovery.Thereby break away from dental surface and reach whitening effect.
Adopt the high friction-type abrasive silicas instead of part calcium carbonate of cleaning, the scuffing of agent of reducing friction to enamel surface.Add the Ca in the inorganic de-sludging factor and the tartar main component carboxyl calcium pyrophosphate
2+Form complex, less Ca
2+Deposition reaches removes the tartar effect.According to morning and evening oral environment difference, add the different antibacterial factors, benefit is early added sodium phytate in the toothpaste, thereby adds PVM/MA and the compound NFD active factors arrival of zinc citrate inhibition bacteriological aftergrowth in the beneficial late toothpaste, effectively removes dental plaque and reaches whitening effect.
The object of the invention realizes through following technical scheme.
According in night on the daytime oral environment daytime oral cavity bacterium content and kind and night oral cavity bacterium content kind difference, the invention provides a kind of benefit benefit combined tooth-paste of whitening evening early.
A kind of combined tooth-paste of whitening beneficial early beneficial evening is made up of benefit whitening toothpaste morning of use in morning and the beneficial late whitening toothpaste that uses evening;
The said benefit early raw material of whitening toothpaste comprises wetting agent, abrasivus, thickening agent, pyrophosphate, phytate, and each raw materials in part by weight is following:
2～80 parts of wetting agents
30～60 parts of abrasivuss
0.8～2 part of thickening agent
0.05 ~ 2 part of pyrophosphate
0.05～2 part of phytate;
The raw material of the late whitening toothpaste of said benefit comprises wetting agent, abrasivus, thickening agent, pyrophosphate, phytate, vinyl methyl ether/copolymer-maleic anhydride and zinc citrate, and each raw materials in part by weight is following:
2～80 parts of wetting agents
30～60 parts of abrasivuss
0.8～2 part of thickening agent
0.05 ~ 2 part of pyrophosphate
0.05～2 part of phytate
0.01～0.05 part of vinyl methyl ether/copolymer-maleic anhydride
0.05～0.2 part of zinc citrate.
Said benefit whitening toothpaste morning and beneficial late whitening toothpaste all can also comprise surfactant, and the parts by weight of surfactant are 1.6～3 parts.
Said abrasivus is the mixture of silicon dioxide and calcium carbonate, and the percentage by weight of silicon dioxide is 5% ~ 45% in the said mixture.
Said wetting agent is preferably more than one in glycerol, sorbitol, propylene glycol or the Polyethylene Glycol.
In the preferred HANSHENGJIAO of said thickening agent, hydroxyethyl-cellulose, carboxymethyl cellulose, hydroxybutyl cellulose, hydroxypropyl methylcellulose, xanthan gum, guar gum or the carbomer more than one.
Said surfactant preferably sodium dodecyl sulfate or disodiumedetate.
Vinyl methyl ether/copolymer-maleic anhydride of the present invention and its method for preparing are disclosed by prior art.
Another object of the present invention is to, provide a kind of benefit late whitening toothpaste, raw material comprises wetting agent, abrasivus, thickening agent, pyrophosphate, phytate, vinyl methyl ether/copolymer-maleic anhydride and zinc citrate, and each raw materials in part by weight is following:
2～80 parts of wetting agents
30～60 parts of abrasivuss
0.8～2 part of thickening agent
0.05 ~ 2 part of pyrophosphate
0.05～2 part of phytate
0.01～0.05 part of vinyl methyl ether/copolymer-maleic anhydride
0.05～0.2 part of zinc citrate.
Can also wrap surfactant, the parts by weight of surfactant are 1.6～3 parts.
Said abrasivus is the mixture of silicon dioxide and calcium carbonate, and the percentage by weight of silicon dioxide is 5% ~ 45% in the said mixture.
Toothpaste of the present invention can also comprise sweeting agent, essence and pigment.
The present invention adopts the high friction-type abrasive silicas instead of part calcium carbonate of cleaning, when reaching the abrasive rate, has reduced the scuffing of abrasivus to enamel surface.
The present invention has a few and beneficial effect with respect to what prior art had:
(1) different according to the morning and evening oral environment, add the different antibacterial factors, benefit is early added organic detergent phytate in the toothpaste, adds the PVM/MA and the zinc citrate composite reactive factor in the beneficial late toothpaste, reaches antibacterially to remove to steep whitening effect the while in the evening on daytime.
(2) allotment silicon dioxide instead of part calcium carbonate, the agent of reducing friction when decontamination is whitened scratches enamel reaching.
(3) the present invention adds the complex of PVM/MA and zinc citrate, in toothpaste with sodium phytate, tetrasodium pyrophosphate, abrasivus is composite, reaches long acting antibiotic and whitening effect, increases the whitening effect of toothpaste.
The specific embodiment
Embodiment 1
A. beneficial whitening toothpaste early, fill a prescription like table 1:
Early fill a prescription and produce basic technology and associative operation process preparation benefit toothpaste morning according to benefit according to toothpaste.
Preparation technology: sodium carboxymethyl cellulose, HANSHENGJIAO, methyl hydroxybenzoate are distributed among Polyethylene Glycol and the glycerol, in addition with saccharin sodium, sorbitol, K
12, sodium pyrophosphate decahydrate is soluble in water makes it expand form homogeneous glue, and suitably ageing, and then with calcium carbonate, silicon dioxide, sodium phytate adds successively, through grinding homogenizing, adds pigment, essence again.Vacuum outgas forms mastic, after detection is qualified, and fill, packing is processed benefit toothpaste finished product early.
Adopt biomembrane clean rate experimental model method to calculate PCR value checking whitening effect.Biomembrane clean rate experimental model (pellicle cleaning ration; PCR); Be to report in nineteen eighty-two by American I ndiana university; Be used to estimate toothpaste and remove the dental exogenous mottle effect, PCR result and clinical experiment have good dependency (r=0.85), and the widely-used PCR of American-European toothpaste industrial quarters estimates the effect that the toothpaste physical property is removed exogenous mottle.Experimental result shows that the present invention's benefit early PCR value of whitening toothpaste is 125, and the PCR value of ordinary toothpaste is 83.
Table 1
Embodiment 2
The toothpaste that whiten beneficial evening, fill a prescription as follows:
Prepare benefit beneficial late toothpaste early according to benefit prescription in evening and according to toothpaste production basic technology and associative operation process.
Preparation technology: copolymer p VM/MA, sodium carboxymethyl cellulose, HANSHENGJIAO, methyl hydroxybenzoate are distributed among Polyethylene Glycol and the glycerol, in addition with saccharin sodium, sorbitol, K
12, sodium pyrophosphate decahydrate is soluble in water makes it expand form homogeneous glue, and suitably ageing, and then with calcium carbonate, silicon dioxide, zinc citrate, sodium phytate adds successively, through grinding homogenizing, adds pigment, essence again.Vacuum outgas forms mastic, after detection is qualified, and fill, packing is processed the toothpaste finished product
This embodiment be sooner or later oral environment the basis on, add effective composition and reach teeth surfaces, remove tobacco dirty remover, exogenous spots such as tea stain arrive the strong tooth effect of whitening.Experimental result shows that the PCR value of the late whitening toothpaste of the present invention's benefit is 127, and the PCR value of ordinary toothpaste is 83.
Benefit is the benefit combined tooth-paste of whitening evening early:
A. beneficial toothpaste of early whitening, fill a prescription as follows:
Preparation technology: sodium carboxymethyl cellulose, HANSHENGJIAO, methyl hydroxybenzoate are distributed among Polyethylene Glycol and the glycerol, it are expanded form homogeneous glue and suitably ageing with saccharin sodium, sorbitol, K12, sodium pyrophosphate decahydrate are soluble in water in addition; And then with the abrasivus powder; Calcium carbonate, silicon dioxide, sodium phytate, adding successively; Through grinding homogenizing, add again pigment, essence.Vacuum outgas forms mastic, after detection is qualified, and fill, packing forms the toothpaste finished product.
This embodiment be sooner or later oral environment the basis on, add effective composition and reach teeth surfaces, remove tobacco dirty remover, exogenous spots such as tea stain arrive the strong tooth effect of whitening.Experimental result shows that the present invention's benefit early PCR value of whitening toothpaste is 119, and the PCR value of ordinary toothpaste is 80.
B. the toothpaste that whiten beneficial evening, fill a prescription as follows:
The corresponding toothpaste bacteriostatic experiment result of beneficial late whitening toothpaste among this embodiment
Exogenous mottle is that they secrete many emplastics makes tooth flavescence or blackening gradually because dental surface exists various bacteria, and the production that suppresses corresponding antibacterial can effectively reduce the mottle area and the mottle degree of depth, thereby reaches whitening effect.
Adopt in the present embodiment benefit benefit combined tooth-paste of whitening evening early, use benefit whitening toothpaste early morning, use evening clinical effectiveness behind the beneficial late whitening toothpaste like table 2, shown in 3 and 4.
Table 2 Lobene mottle area index and mottle depth factor standards of grading
The meansigma methods of two treatment group mottle area indexs all is 1.65 before the clinical observation of baseline inspection data.The meansigma methods of mottle depth factor, experimental group toothpaste are 1.81, and matched group toothpaste is 1.79.Through statistical analysis, the exogenous spot index of the tooth of matched group mean is 1.72, and experimental group is 173, and check shows both indifferences on statistics.
Lobene mottle area index and mottle depth factor during the inspection of table 2 baseline
★ is average ± standard deviation
Lobene mottle area index and mottle depth factor after 4 weeks of table 3 treatment
★ is average ± standard deviation
This embodiment be sooner or later oral environment the basis on, add effective composition and reach teeth surfaces, remove tobacco dirty remover, exogenous spots such as tea stain arrive the strong tooth effect of whitening.
According to the announcement and the instruction of above-mentioned description, those skilled in the art in the invention can also change and revise above-mentioned embodiment.Therefore, the specific embodiment that discloses and describe above the present invention is not limited to also should fall in the protection domain of claim of the present invention modifications more of the present invention and change.In addition, although used some specific terms in this description, these terms are explanation for ease just, the present invention is not constituted any restriction.
Claims (9)
1. a combined tooth-paste of whitening beneficial early beneficial evening is characterized in that, is made up of benefit whitening toothpaste morning of use in morning and the beneficial late whitening toothpaste that uses evening;
The said benefit early raw material of whitening toothpaste comprises wetting agent, abrasivus, thickening agent, pyrophosphate, phytate, and each raw materials in part by weight is following:
2～80 parts of wetting agents
30～60 parts of abrasivuss
0.8～2 part of thickening agent
0.05 ~ 2 part of pyrophosphate
0.05～2 part of phytate;
The raw material of the late whitening toothpaste of said benefit comprises wetting agent, abrasivus, thickening agent, pyrophosphate, phytate, vinyl methyl ether/copolymer-maleic anhydride and zinc citrate, and each raw materials in part by weight is following:
2～80 parts of wetting agents
30～60 parts of abrasivuss
0.8～2 part of thickening agent
0.05 ~ 2 part of pyrophosphate
0.05～2 part of phytate
0.01～0.05 part of vinyl methyl ether/copolymer-maleic anhydride
0.05～0.2 part of zinc citrate.
2. combined tooth-paste according to claim 1 is characterized in that, said benefit whitening toothpaste morning and beneficial late whitening toothpaste also comprise surfactant, and the parts by weight of surfactant are 1.6～3 parts.
3. combined tooth-paste according to claim 1 and 2 is characterized in that, said abrasivus is the mixture of silicon dioxide and calcium carbonate, and the percentage by weight of silicon dioxide is 5% ~ 45% in the said mixture.
4. combined tooth-paste according to claim 1 and 2 is characterized in that, said wetting agent is more than one in glycerol, sorbitol, propylene glycol or the Polyethylene Glycol.
5. combined tooth-paste according to claim 1 and 2 is characterized in that, said thickening agent is more than one in HANSHENGJIAO, hydroxyethyl-cellulose, carboxymethyl cellulose, hydroxybutyl cellulose, hydroxypropyl methylcellulose, xanthan gum, guar gum or the carbomer.
6. combined tooth-paste according to claim 1 and 2 is characterized in that, said surfactant is sodium lauryl sulphate or disodiumedetate.
7. the late whitening toothpaste of benefit is characterized in that raw material comprises wetting agent, abrasivus, thickening agent, pyrophosphate, phytate, vinyl methyl ether/copolymer-maleic anhydride and zinc citrate, and each raw materials in part by weight is following:
2～80 parts of wetting agents
30～60 parts of abrasivuss
0.8～2 part of thickening agent
0.05 ~ 2 part of pyrophosphate
0.05～2 part of phytate
0.01～0.05 part of vinyl methyl ether/copolymer-maleic anhydride
0.05～0.2 part of zinc citrate.
8. the late whitening toothpaste of a kind of benefit according to claim 7 is characterized in that, also wraps surfactant, and the parts by weight of surfactant are 1.6～3 parts.
9. according to claim 7 or the late whitening toothpaste of 8 described a kind of benefits, it is characterized in that said abrasivus is the mixture of silicon dioxide and calcium carbonate, the percentage by weight of silicon dioxide is 5% ~ 45% in the said mixture.
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| CN106619187A (en) * | 2017-01-24 | 2017-05-10 | 广州薇美姿实业有限公司 | Composition for preventing dental calculus and application |
| CN106619187B (en) * | 2017-01-24 | 2019-07-16 | 广州薇美姿实业有限公司 | A kind of composition of pre- dental calculus preventing and application |
| CN107463529A (en) * | 2017-06-26 | 2017-12-12 | 广州薇美姿实业有限公司 | A kind of toothpaste cleaning force appraisal procedure |
| CN108078822A (en) * | 2018-01-17 | 2018-05-29 | 山东大学 | A kind of morning-night special type toothpaste |
| CN110302102A (en) * | 2019-07-30 | 2019-10-08 | 安徽氧趣生物科技有限公司 | A kind of ozone sustained release whitening toothpaste |
| CN112641646A (en) * | 2019-10-12 | 2021-04-13 | 福建爱洁丽日化有限公司 | Toothpaste with whitening complexing agent and preparation method thereof |
| CN113476326A (en) * | 2021-06-30 | 2021-10-08 | 广州名大实业有限公司 | Toothpaste formula with efficient whitening function |
| CN115804732A (en) * | 2022-12-08 | 2023-03-17 | 云南白药集团健康产品有限公司 | Whitening and tooth-protecting composition and gargle thereof |
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Denomination of invention: Whitening toothpaste suitable for evening and combined whitening toothpaste suitable for morning and evening Effective date of registration: 20131213 Granted publication date: 20130717 Pledgee: Guangzhou first pawn Co., Ltd. Pledgor: Guangzhou Weimeizi Personal Care Supplies Co., Ltd. Registration number: 2013990000969 |
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