CN115316493B - 一种乳酸菌-脂质体制剂、其制备方法及其应用 - Google Patents
一种乳酸菌-脂质体制剂、其制备方法及其应用 Download PDFInfo
- Publication number
- CN115316493B CN115316493B CN202211023786.XA CN202211023786A CN115316493B CN 115316493 B CN115316493 B CN 115316493B CN 202211023786 A CN202211023786 A CN 202211023786A CN 115316493 B CN115316493 B CN 115316493B
- Authority
- CN
- China
- Prior art keywords
- liposome
- lactobacillus
- liposome preparation
- lactic acid
- acid bacteria
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
- 239000002502 liposome Substances 0.000 title claims abstract description 120
- 238000002360 preparation method Methods 0.000 title claims abstract description 108
- JVTAAEKCZFNVCJ-UHFFFAOYSA-N lactic acid Chemical compound CC(O)C(O)=O JVTAAEKCZFNVCJ-UHFFFAOYSA-N 0.000 title claims description 56
- 235000014655 lactic acid Nutrition 0.000 title claims description 28
- 239000004310 lactic acid Substances 0.000 title claims description 28
- 241000186660 Lactobacillus Species 0.000 claims abstract description 43
- 229940039696 lactobacillus Drugs 0.000 claims abstract description 43
- 239000000843 powder Substances 0.000 claims abstract description 29
- 239000003995 emulsifying agent Substances 0.000 claims abstract description 18
- HVYWMOMLDIMFJA-DPAQBDIFSA-N cholesterol Chemical compound C1C=C2C[C@@H](O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H]([C@H](C)CCCC(C)C)[C@@]1(C)CC2 HVYWMOMLDIMFJA-DPAQBDIFSA-N 0.000 claims description 14
- 239000011259 mixed solution Substances 0.000 claims description 13
- 238000003756 stirring Methods 0.000 claims description 13
- 239000012528 membrane Substances 0.000 claims description 10
- 238000009210 therapy by ultrasound Methods 0.000 claims description 10
- 241000894006 Bacteria Species 0.000 claims description 8
- QHZLMUACJMDIAE-UHFFFAOYSA-N 1-monopalmitoylglycerol Chemical compound CCCCCCCCCCCCCCCC(=O)OCC(O)CO QHZLMUACJMDIAE-UHFFFAOYSA-N 0.000 claims description 7
- VBICKXHEKHSIBG-UHFFFAOYSA-N 1-monostearoylglycerol Chemical compound CCCCCCCCCCCCCCCCCC(=O)OCC(O)CO VBICKXHEKHSIBG-UHFFFAOYSA-N 0.000 claims description 7
- 235000012000 cholesterol Nutrition 0.000 claims description 7
- 229940096898 glyceryl palmitate Drugs 0.000 claims description 7
- 229940075529 glyceryl stearate Drugs 0.000 claims description 7
- 238000002844 melting Methods 0.000 claims description 7
- 230000008018 melting Effects 0.000 claims description 7
- 238000002156 mixing Methods 0.000 claims description 5
- 239000007921 spray Substances 0.000 claims description 5
- 238000005507 spraying Methods 0.000 claims description 5
- 241000194032 Enterococcus faecalis Species 0.000 claims description 3
- 241000194031 Enterococcus faecium Species 0.000 claims description 3
- 239000003674 animal food additive Substances 0.000 claims description 3
- 229940032049 enterococcus faecalis Drugs 0.000 claims description 3
- 238000012545 processing Methods 0.000 claims description 2
- 238000000034 method Methods 0.000 abstract description 14
- 241001465754 Metazoa Species 0.000 abstract description 12
- 230000009286 beneficial effect Effects 0.000 abstract description 5
- 210000001035 gastrointestinal tract Anatomy 0.000 abstract description 5
- 210000000170 cell membrane Anatomy 0.000 abstract description 3
- 230000004927 fusion Effects 0.000 abstract description 3
- 210000004211 gastric acid Anatomy 0.000 abstract description 3
- 238000013268 sustained release Methods 0.000 abstract description 3
- 239000012730 sustained-release form Substances 0.000 abstract description 3
- 238000002474 experimental method Methods 0.000 description 15
- 239000002253 acid Substances 0.000 description 14
- 238000004321 preservation Methods 0.000 description 12
- 238000012258 culturing Methods 0.000 description 9
- 239000001963 growth medium Substances 0.000 description 9
- 238000012360 testing method Methods 0.000 description 9
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 7
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 description 6
- 230000000052 comparative effect Effects 0.000 description 6
- 244000005700 microbiome Species 0.000 description 5
- 230000001580 bacterial effect Effects 0.000 description 4
- 239000000463 material Substances 0.000 description 4
- 239000002356 single layer Substances 0.000 description 4
- 239000000243 solution Substances 0.000 description 4
- 239000003242 anti bacterial agent Substances 0.000 description 3
- 229940088710 antibiotic agent Drugs 0.000 description 3
- 210000004027 cell Anatomy 0.000 description 3
- 230000000694 effects Effects 0.000 description 3
- 230000008014 freezing Effects 0.000 description 3
- 238000007710 freezing Methods 0.000 description 3
- 239000007788 liquid Substances 0.000 description 3
- 244000144972 livestock Species 0.000 description 3
- 229910052757 nitrogen Inorganic materials 0.000 description 3
- 125000005456 glyceride group Chemical group 0.000 description 2
- 238000002955 isolation Methods 0.000 description 2
- 238000004519 manufacturing process Methods 0.000 description 2
- 239000003960 organic solvent Substances 0.000 description 2
- 244000144977 poultry Species 0.000 description 2
- 238000003672 processing method Methods 0.000 description 2
- 230000001737 promoting effect Effects 0.000 description 2
- 230000001007 puffing effect Effects 0.000 description 2
- 230000001105 regulatory effect Effects 0.000 description 2
- 208000035240 Disease Resistance Diseases 0.000 description 1
- 241000194033 Enterococcus Species 0.000 description 1
- 239000004098 Tetracycline Substances 0.000 description 1
- 239000000969 carrier Substances 0.000 description 1
- 239000003153 chemical reaction reagent Substances 0.000 description 1
- 238000007796 conventional method Methods 0.000 description 1
- 230000007547 defect Effects 0.000 description 1
- 238000011161 development Methods 0.000 description 1
- 239000003814 drug Substances 0.000 description 1
- 229940079593 drug Drugs 0.000 description 1
- 239000003640 drug residue Substances 0.000 description 1
- 230000002496 gastric effect Effects 0.000 description 1
- 230000036737 immune function Effects 0.000 description 1
- 210000000987 immune system Anatomy 0.000 description 1
- 230000036039 immunity Effects 0.000 description 1
- 230000002401 inhibitory effect Effects 0.000 description 1
- 230000000968 intestinal effect Effects 0.000 description 1
- 230000007774 longterm Effects 0.000 description 1
- 230000000813 microbial effect Effects 0.000 description 1
- 235000010482 polyoxyethylene sorbitan monooleate Nutrition 0.000 description 1
- 229920000053 polysorbate 80 Polymers 0.000 description 1
- 239000006041 probiotic Substances 0.000 description 1
- 230000000529 probiotic effect Effects 0.000 description 1
- 235000018291 probiotics Nutrition 0.000 description 1
- 210000002784 stomach Anatomy 0.000 description 1
- 238000010998 test method Methods 0.000 description 1
- 229960002180 tetracycline Drugs 0.000 description 1
- 229930101283 tetracycline Natural products 0.000 description 1
- 235000019364 tetracycline Nutrition 0.000 description 1
- 150000003522 tetracyclines Chemical class 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23K—FODDER
- A23K10/00—Animal feeding-stuffs
- A23K10/10—Animal feeding-stuffs obtained by microbiological or biochemical processes
- A23K10/16—Addition of microorganisms or extracts thereof, e.g. single-cell proteins, to feeding-stuff compositions
- A23K10/18—Addition of microorganisms or extracts thereof, e.g. single-cell proteins, to feeding-stuff compositions of live microorganisms
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23K—FODDER
- A23K20/00—Accessory food factors for animal feeding-stuffs
- A23K20/10—Organic substances
- A23K20/158—Fatty acids; Fats; Products containing oils or fats
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23K—FODDER
- A23K20/00—Accessory food factors for animal feeding-stuffs
- A23K20/10—Organic substances
- A23K20/168—Steroids
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23K—FODDER
- A23K40/00—Shaping or working-up of animal feeding-stuffs
- A23K40/30—Shaping or working-up of animal feeding-stuffs by encapsulating; by coating
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A40/00—Adaptation technologies in agriculture, forestry, livestock or agroalimentary production
- Y02A40/70—Adaptation technologies in agriculture, forestry, livestock or agroalimentary production in livestock or poultry
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Polymers & Plastics (AREA)
- Engineering & Computer Science (AREA)
- Zoology (AREA)
- Food Science & Technology (AREA)
- Animal Husbandry (AREA)
- Microbiology (AREA)
- Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Biomedical Technology (AREA)
- Biotechnology (AREA)
- Molecular Biology (AREA)
- Physiology (AREA)
- Medicinal Preparation (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
Abstract
Description
Claims (8)
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN202211023786.XA CN115316493B (zh) | 2022-08-24 | 2022-08-24 | 一种乳酸菌-脂质体制剂、其制备方法及其应用 |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN202211023786.XA CN115316493B (zh) | 2022-08-24 | 2022-08-24 | 一种乳酸菌-脂质体制剂、其制备方法及其应用 |
Publications (2)
Publication Number | Publication Date |
---|---|
CN115316493A CN115316493A (zh) | 2022-11-11 |
CN115316493B true CN115316493B (zh) | 2024-04-05 |
Family
ID=83925573
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CN202211023786.XA Active CN115316493B (zh) | 2022-08-24 | 2022-08-24 | 一种乳酸菌-脂质体制剂、其制备方法及其应用 |
Country Status (1)
Country | Link |
---|---|
CN (1) | CN115316493B (zh) |
Citations (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
KR20070104140A (ko) * | 2006-04-21 | 2007-10-25 | (주)케비젠 | 유산균 다중 마이크로캡슐의 제조방법, 이 방법에 의해제조된 마이크로캡슐 및 이를 포함하는 제품 |
TW200846466A (en) * | 2007-05-25 | 2008-12-01 | yong-yu Lai | Probiotic powder composition and product thereof |
CN108990983A (zh) * | 2018-08-31 | 2018-12-14 | 成都特普生物科技股份有限公司 | 一种缓释微生物菌剂 |
CN109010321A (zh) * | 2018-09-27 | 2018-12-18 | 佛山市正典生物技术有限公司 | 一种具有缓释作用的微囊颗粒的制备方法 |
CN113543645A (zh) * | 2020-01-28 | 2021-10-22 | 萃奥密公司 | 肠溶组合物、包含该肠溶组合物的饮食品、控制该肠溶组合物的崩解时间的方法及其制备方法 |
CN113892650A (zh) * | 2020-06-18 | 2022-01-07 | 湖南农业大学 | 一种益生菌脂质体及其制备方法 |
-
2022
- 2022-08-24 CN CN202211023786.XA patent/CN115316493B/zh active Active
Patent Citations (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
KR20070104140A (ko) * | 2006-04-21 | 2007-10-25 | (주)케비젠 | 유산균 다중 마이크로캡슐의 제조방법, 이 방법에 의해제조된 마이크로캡슐 및 이를 포함하는 제품 |
TW200846466A (en) * | 2007-05-25 | 2008-12-01 | yong-yu Lai | Probiotic powder composition and product thereof |
CN108990983A (zh) * | 2018-08-31 | 2018-12-14 | 成都特普生物科技股份有限公司 | 一种缓释微生物菌剂 |
CN109010321A (zh) * | 2018-09-27 | 2018-12-18 | 佛山市正典生物技术有限公司 | 一种具有缓释作用的微囊颗粒的制备方法 |
CN113543645A (zh) * | 2020-01-28 | 2021-10-22 | 萃奥密公司 | 肠溶组合物、包含该肠溶组合物的饮食品、控制该肠溶组合物的崩解时间的方法及其制备方法 |
CN113892650A (zh) * | 2020-06-18 | 2022-01-07 | 湖南农业大学 | 一种益生菌脂质体及其制备方法 |
Non-Patent Citations (1)
Title |
---|
"Protection of Bifidobacterium lactis and Lactobacillus acidophilus by microencapsulation using spray-chilling",Daniela de Lara Pedroso,等,第127-132页,International Dairy Journal,第26卷;Daniela de Lara Pedroso,等;Protection of Bifidobacterium lactis and Lactobacillus acidophilus by microencapsulation using spray-chilling;第26卷;第127-132页 * |
Also Published As
Publication number | Publication date |
---|---|
CN115316493A (zh) | 2022-11-11 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
AU2006257751B9 (en) | Probiotic health and performance promoting food, feed and/or drinking water additive and its use | |
CN113736699B (zh) | 一种屎肠球菌菌剂及其用途 | |
US4396631A (en) | Bifidobacterium-containing confectionery tablets and process for preparing the same | |
JPH10330274A (ja) | 鳥類用生菌剤の投与方法 | |
EP0022341B1 (en) | Method and starter compositions for the growth of acid producing bacteria and bacterial compositions produced thereby | |
CN112544977A (zh) | 一种多层包被益生菌微胶囊的制备方法 | |
CN107354097B (zh) | 一种在常温下提高液态乳酸菌存活率的乳酸菌保存剂及其应用 | |
CN111903838A (zh) | 一种酵母培养物与复合乳酸菌制剂及其制备方法 | |
CN103283948A (zh) | 一种以两歧双歧杆菌为主的微生态制剂 | |
CN109055276A (zh) | 一种液态混菌菌剂制备方法 | |
CN112244163A (zh) | 一种无抗仔猪饲料添加剂及其制备方法、应用方法 | |
CN101416681B (zh) | 富硒乳酸粪肠球菌三层微胶囊及其制备方法和应用 | |
CN115316493B (zh) | 一种乳酸菌-脂质体制剂、其制备方法及其应用 | |
CN112375701A (zh) | 改善牛羊等反刍动物肠道环境的微生物制剂及其制备方法 | |
CN108850534A (zh) | 一种复合微生物发酵饲料及其制备方法 | |
CN115226771B (zh) | 一种抑制幽门螺旋杆菌的风味酸奶及其制备方法 | |
CN114128808A (zh) | 助消化的鱼类液体饲料添加剂及其制备方法和应用 | |
CN110373361A (zh) | 一种乳酸片球菌微囊及其制备方法 | |
JPWO2020158737A1 (ja) | 保存安定性と、耐胃液分解安定性を付与したプロバイオティクス組成物 | |
CN109156606A (zh) | 一种在动物肠道精准定位释放的复合型乳酸菌制剂制备方法 | |
CN114304688B (zh) | 玉米醇溶蛋白包被剂、利用该包被剂进行包被的益生菌制剂及其制备方法 | |
CN109486713A (zh) | 一种液态复合乳酸杆菌制剂及其制备方法与应用 | |
CN114762527B (zh) | 一种含活性益生菌的爽口片及其制备方法 | |
CN107114594A (zh) | 一种含益生菌的雏鸡保健剂及生产方法 | |
CN107245467A (zh) | 一种养殖微生物制剂及其制备方法 |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
PB01 | Publication | ||
PB01 | Publication | ||
SE01 | Entry into force of request for substantive examination | ||
SE01 | Entry into force of request for substantive examination | ||
GR01 | Patent grant | ||
GR01 | Patent grant | ||
CB03 | Change of inventor or designer information |
Inventor after: Du Jingde Inventor after: Xie Jianming Inventor after: Xia Lin Inventor after: Li Yun Inventor after: Jian Zhiyin Inventor after: Wang Xuanjie Inventor after: Chen Guangyi Inventor after: Li Wei Inventor after: Li Yuekun Inventor before: Du Jingde Inventor before: Xie Jianming Inventor before: Xia Lin Inventor before: Li Yun Inventor before: Jian Zhiyun Inventor before: Wang Xuanjie Inventor before: Chen Guangyi Inventor before: Li Wei Inventor before: Li Yuekun |
|
CB03 | Change of inventor or designer information |