CN115315530A - 使用特定基因中cpg甲基化改变以诊断膀胱癌的组合物及其用途 - Google Patents
使用特定基因中cpg甲基化改变以诊断膀胱癌的组合物及其用途 Download PDFInfo
- Publication number
- CN115315530A CN115315530A CN202180023436.0A CN202180023436A CN115315530A CN 115315530 A CN115315530 A CN 115315530A CN 202180023436 A CN202180023436 A CN 202180023436A CN 115315530 A CN115315530 A CN 115315530A
- Authority
- CN
- China
- Prior art keywords
- methylation
- bladder cancer
- gene
- march11
- iffo1
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Images
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
- C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
- C12Q1/6886—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material for cancer
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6813—Hybridisation assays
- C12Q1/6834—Enzymatic or biochemical coupling of nucleic acids to a solid phase
- C12Q1/6837—Enzymatic or biochemical coupling of nucleic acids to a solid phase using probe arrays or probe chips
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2600/00—Oligonucleotides characterized by their use
- C12Q2600/154—Methylation markers
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2600/00—Oligonucleotides characterized by their use
- C12Q2600/156—Polymorphic or mutational markers
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2600/00—Oligonucleotides characterized by their use
- C12Q2600/158—Expression markers
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2600/00—Oligonucleotides characterized by their use
- C12Q2600/16—Primer sets for multiplex assays
Landscapes
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Engineering & Computer Science (AREA)
- Immunology (AREA)
- Pathology (AREA)
- Analytical Chemistry (AREA)
- Zoology (AREA)
- Genetics & Genomics (AREA)
- Wood Science & Technology (AREA)
- Physics & Mathematics (AREA)
- Biotechnology (AREA)
- Microbiology (AREA)
- Molecular Biology (AREA)
- Hospice & Palliative Care (AREA)
- Biophysics (AREA)
- Oncology (AREA)
- Biochemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Enzymes And Modification Thereof (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| KR1020200010053A KR102637032B1 (ko) | 2020-01-28 | 2020-01-28 | 특정 유전자의 CpG 메틸화 변화를 이용한 방광암 진단용 조성물 및 이의 용도 |
| KR10-2020-0010053 | 2020-01-28 | ||
| PCT/KR2021/001154 WO2021154009A1 (ko) | 2020-01-28 | 2021-01-28 | 특정 유전자의 CpG 메틸화 변화를 이용한 방광암 진단용 조성물 및 이의 용도 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN115315530A true CN115315530A (zh) | 2022-11-08 |
Family
ID=77078172
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN202180023436.0A Pending CN115315530A (zh) | 2020-01-28 | 2021-01-28 | 使用特定基因中cpg甲基化改变以诊断膀胱癌的组合物及其用途 |
Country Status (6)
| Country | Link |
|---|---|
| US (1) | US20230084248A1 (https=) |
| EP (1) | EP4098755A4 (https=) |
| JP (1) | JP7828613B2 (https=) |
| KR (1) | KR102637032B1 (https=) |
| CN (1) | CN115315530A (https=) |
| WO (1) | WO2021154009A1 (https=) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN118147311A (zh) * | 2024-05-13 | 2024-06-07 | 北京橡鑫生物科技有限公司 | 尿路上皮癌甲基化标志物试剂盒 |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2023083348A1 (zh) * | 2021-11-15 | 2023-05-19 | 武汉艾米森生命科技有限公司 | 用于食管癌诊断的甲基化检测试剂及试剂盒 |
| CN116168761B (zh) * | 2023-04-18 | 2023-06-30 | 珠海圣美生物诊断技术有限公司 | 核酸序列特征区域确定方法、装置、电子设备及存储介质 |
| CN118230812A (zh) * | 2023-12-15 | 2024-06-21 | 王姝瑶 | 一种精确筛查的基因检测方法 |
Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20120101023A1 (en) * | 2009-04-20 | 2012-04-26 | Erasmus University Medical Center Rotterdam | Method of diagnosing bladder cancer |
| WO2016108403A1 (ko) * | 2014-12-30 | 2016-07-07 | 충북대학교 산학협력단 | 방광암 예후 진단 마커로서 rsph9의 용도 |
| US20180148776A1 (en) * | 2015-02-24 | 2018-05-31 | Zymo Research Corporation | Assays to determine dna methylation and dna methylation markers of cancer |
| CN108350504A (zh) * | 2015-06-24 | 2018-07-31 | Ucl商业有限公司 | 膀胱癌的诊断方法 |
Family Cites Families (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2001077375A2 (en) | 2000-04-06 | 2001-10-18 | Epigenomics Ag | Diagnosis of diseases associated with gene regulation |
| US20090298054A1 (en) * | 2004-07-18 | 2009-12-03 | Epigenomics Ag | Epigenetic methods and nucleic acids for the detection of breast cell proliferative disorders |
| EP2311984A1 (en) * | 2004-12-02 | 2011-04-20 | Epigenomics AG | Methods and nucleic acids for the analysis of gene expression associated with the prognosis of prostate cell proliferative disorders |
| EA013634B1 (ru) * | 2005-04-15 | 2010-06-30 | Эпиджиномикс Аг | Способы и нуклеиновые кислоты для анализов клеточных пролиферативных нарушений |
| EP2147124A4 (en) * | 2007-04-11 | 2010-07-14 | Manuel Esteller | EPIGENETIC BIOMARKERS FOR EARLY DETECTION, EFFICIENT TREATMENT AND RETENTION OF CANCER |
| US8399193B2 (en) * | 2007-08-30 | 2013-03-19 | City Of Hope | DNA methylation biomarkers for lung cancer |
| EP2390371A1 (en) * | 2007-11-30 | 2011-11-30 | Genomictree, Inc. | Diagnosis kit and chip for bladder cancer using bladder cancer specific methylation marker gene |
| MX2011000655A (es) * | 2008-07-18 | 2011-03-21 | Oragenics Inc | Composiciones para la deteccion y tratamiento de cancer colorrectal. |
| EP2233590A1 (en) * | 2009-01-28 | 2010-09-29 | AIT Austrian Institute of Technology GmbH | Methylation assay |
| US20130065228A1 (en) * | 2011-06-01 | 2013-03-14 | University Of Southern California | Genome-scale analysis of aberrant dna methylation in colorectal cancer |
| US9096905B2 (en) * | 2012-02-23 | 2015-08-04 | Medical Diagnostic Laboratories, Llc | Detecting DNA methylation of BCL2, CDKN2A and NID2 genes to predict bladder cancer in humans |
| WO2017201606A1 (en) * | 2016-05-04 | 2017-11-30 | Queen's University At Kingston | Cell-free detection of methylated tumour dna |
| US11207340B2 (en) * | 2017-05-26 | 2021-12-28 | The Chinese University Of Hong Kong | Tumor suppressor TET1 and uses thereof |
| WO2019195941A1 (en) * | 2018-04-13 | 2019-10-17 | London Health Sciences Centre Research Inc. | Dna methylation assays and methods |
| MX2020013994A (es) * | 2018-06-22 | 2021-05-27 | Bluestar Genomics Inc | Análisis de hidroximetilación de muestras de ácido nucleico sin células para asignación de tejido de origen, y métodos relacionados de uso. |
| US10249912B1 (en) | 2018-07-18 | 2019-04-02 | Lg Chem, Ltd. | Electrical control system |
-
2020
- 2020-01-28 KR KR1020200010053A patent/KR102637032B1/ko active Active
-
2021
- 2021-01-28 CN CN202180023436.0A patent/CN115315530A/zh active Pending
- 2021-01-28 EP EP21747758.7A patent/EP4098755A4/en active Pending
- 2021-01-28 JP JP2022546378A patent/JP7828613B2/ja active Active
- 2021-01-28 US US17/795,848 patent/US20230084248A1/en active Pending
- 2021-01-28 WO PCT/KR2021/001154 patent/WO2021154009A1/ko not_active Ceased
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20120101023A1 (en) * | 2009-04-20 | 2012-04-26 | Erasmus University Medical Center Rotterdam | Method of diagnosing bladder cancer |
| WO2016108403A1 (ko) * | 2014-12-30 | 2016-07-07 | 충북대학교 산학협력단 | 방광암 예후 진단 마커로서 rsph9의 용도 |
| US20180148776A1 (en) * | 2015-02-24 | 2018-05-31 | Zymo Research Corporation | Assays to determine dna methylation and dna methylation markers of cancer |
| CN108350504A (zh) * | 2015-06-24 | 2018-07-31 | Ucl商业有限公司 | 膀胱癌的诊断方法 |
Non-Patent Citations (3)
| Title |
|---|
| BRENNA ANE: "Identification of novel epigenetic masterkeys in cancer - with potential diagnostic value", 《DUO RESEARCH ARCHIVE》, 31 May 2014 (2014-05-31) * |
| HYUNG-YOON YOON等: "RSPH9 methylation pattern as a prognostic indicator in patients with non-muscle invasive bladder cancer", 《ONCOL REP》, vol. 35, no. 2, 11 November 2015 (2015-11-11), pages 1195 - 203, XP055832508, DOI: 10.3892/or.2015.4409 * |
| MIHAELA CAMPAN等: "Genome-Scale Screen for DNA Methylation-Based Detection Markers for Ovarian Cancer", 《PLOS ONE》, vol. 6, no. 12, 7 December 2011 (2011-12-07), pages 28141 * |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN118147311A (zh) * | 2024-05-13 | 2024-06-07 | 北京橡鑫生物科技有限公司 | 尿路上皮癌甲基化标志物试剂盒 |
Also Published As
| Publication number | Publication date |
|---|---|
| EP4098755A1 (en) | 2022-12-07 |
| JP2023513039A (ja) | 2023-03-30 |
| KR20210096509A (ko) | 2021-08-05 |
| KR102637032B1 (ko) | 2024-02-15 |
| US20230084248A1 (en) | 2023-03-16 |
| EP4098755A4 (en) | 2024-06-26 |
| JP7828613B2 (ja) | 2026-03-12 |
| WO2021154009A1 (ko) | 2021-08-05 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN108350504B (zh) | 膀胱癌的诊断方法 | |
| CN101675171B (zh) | 用basp1基因和/或srd5a2基因中的甲基化胞嘧啶检测肝癌、肝癌风险、肝癌复发风险、肝癌恶化和肝癌随时间进展的方法 | |
| CN110387420B (zh) | 用于子宫内膜癌诊断的试剂盒以及应用 | |
| US20150361502A1 (en) | Method for screening cancer | |
| JP7828613B2 (ja) | 特定の遺伝子のCpGメチル化の変化を利用した膀胱癌診断用組成物およびその使用 | |
| CN110387421A (zh) | 用于肺癌检测的DNA甲基化qPCR试剂盒及使用方法 | |
| JP2024020392A (ja) | 特定の遺伝子のcpgメチル化変化を利用した肝癌診断用組成物およびその使用 | |
| WO2010118559A1 (zh) | 一种癌症筛检的方法 | |
| TW202142549A (zh) | 腫瘤檢測試劑及試劑盒 | |
| CN110484621A (zh) | 一种肝癌早期预警的方法 | |
| EP4647511A1 (en) | Gene marker combination, kit, and detection method | |
| KR20260008061A (ko) | GLRB 유전자의 CpG 메틸화 변화를 이용한 대장암, 직장암 또는 대장 선종 진단용 조성물 및 이의 용도 | |
| CN113355415B (zh) | 用于食管癌诊断或辅助诊断的检测试剂及试剂盒 | |
| KR20210044441A (ko) | 특정 유전자의 CpG 메틸화 변화를 이용한 대장암, 직장암 또는 대장 선종 진단용 조성물 및 이의 용도 | |
| CN116144782A (zh) | 一种用于肺癌检测的组合标志物及其应用 | |
| US11535897B2 (en) | Composite epigenetic biomarkers for accurate screening, diagnosis and prognosis of colorectal cancer | |
| US20230383356A1 (en) | Composition for diagnosing colorectal cancer, rectal cancer or colorectal adenoma by using cpg methylation change of linc01798 gene, and use thereof | |
| CN114107498A (zh) | 结直肠癌血液检测标记物及其应用 | |
| CN119193832A (zh) | 用于检测卵巢癌的组合物及其用途 | |
| CN111662980A (zh) | 一种肺癌检测试剂及试剂盒 | |
| CN117431321A (zh) | 一种用于前列腺癌或癌前病变检测的核酸组合物、试剂盒及应用 | |
| CN109868320A (zh) | 用于检测食道癌的组合物及其用途 | |
| KR20230105973A (ko) | 특정 유전자의 CpG 메틸화 변화를 이용한 전립선암 진단용 조성물 및 이의 용도 | |
| CN115961048B (zh) | 一种基因甲基化检测引物组合、试剂及其应用 | |
| TWI753455B (zh) | 用以評估個體罹患胃癌或癌前病變之風險的方法、其套組、其分析器及其生物標誌 |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PB01 | Publication | ||
| PB01 | Publication | ||
| SE01 | Entry into force of request for substantive examination | ||
| SE01 | Entry into force of request for substantive examination |