CN115300409A - Component for preventing and improving white hair and alopecia and application thereof - Google Patents
Component for preventing and improving white hair and alopecia and application thereof Download PDFInfo
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- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
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- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/49—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
- A61K8/4973—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with oxygen as the only hetero atom
- A61K8/498—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with oxygen as the only hetero atom having 6-membered rings or their condensed derivatives, e.g. coumarin
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- A61Q5/00—Preparations for care of the hair
- A61Q5/02—Preparations for cleaning the hair
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
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- A61Q5/12—Preparations containing hair conditioners
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- A—HUMAN NECESSITIES
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- A61Q7/00—Preparations for affecting hair growth
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Abstract
A composition for preventing and improving canities and alopecia comprises at least one of eriodictyol, 7-O-methyl eriodictyol, and eriodictyol-7-O-glucoside; the hair conditioner also comprises auxiliary materials and a solvent, wherein the auxiliary materials comprise but are not limited to surfactants, hair pomades, dandruff removing and itching relieving agents, thickening agents, preservatives, nutritional additives and pH regulators, and the solvent comprises but is not limited to deionized water, ethanol, propylene glycol and glycerol; at least one of eriodictyol, 7-O-methyl eriodictyol, and eriodictyol-7-O-glucoside can be used as a washing product; can activate scalp hair follicle and melanocyte, promote the formation of melanin in new hair and hair growth in short period, and effectively improve white hair and alopecia; the components are safe and mild, do not cause irritation to scalp, and do not cause anaphylaxis or inflammatory reaction.
Description
Technical Field
The invention relates to a component for preventing and improving white hair and alopecia and application thereof.
Background
With environmental factors such as age increase, mental stress and ultraviolet radiation, white hair and alopecia are prominent hair problems in middle-aged and elderly people and part of young people, which not only bring about the trouble of personal image in work and life, but also bring about negative effects from low quality and anxiety in the psychological level. If hair dye is selected to be used for dyeing white hair black, on one hand, the hair dye cannot improve the white hair from the source, and on the other hand, p-phenylenediamine contained in the hair dye easily causes irritation to skin, causes allergy or inflammation, damages hair quality, and aggravates white hair and alopecia. The discovery of improving deaths by taking drugs is an effective solution, but the side effects of drugs can be harmful to health and this approach is not suitable for all people. Therefore, how to prevent and improve the white hair and the alopecia under the effective, safe and non-irritant conditions is a great technical problem to be solved at present.
Disclosure of Invention
The invention aims to overcome the defects in the prior art and provide a component for preventing and improving white hair and alopecia and application thereof.
In order to solve the technical problems, the invention provides the following technical scheme: a composition for preventing and improving canities and alopecia is characterized by comprising at least one of eriodictyol, 7-O-methyl eriodictyol, and eriodictyol-7-O-glucoside.
Preferably, the shampoo also comprises auxiliary materials and a solvent, wherein the auxiliary materials comprise but are not limited to surfactants, hair pomades, anti-dandruff antipruritic agents, thickening agents, preservatives, nutritional additives and pH regulators, and the solvent comprises but is not limited to deionized water, ethanol, propylene glycol and glycerol.
Preferably, the surfactant is at least one of cetyltrimethylammonium chloride, octadecyltrimethylammonium chloride, docosyltrimethylammonium chloride, dioctadecyltrimethylammonium chloride, dodecyldipolyoxyethylene, sodium sulfosuccinate sulfonate, sodium lauryl sulfate, ammonium lauryl sulfate, coco-glucoside, sodium fatty alcohol polyoxyethylene ether sulfate, sodium laureth sulfate, ammonium laureth sulfate, lauramidopropyl ammonium oxide, dodecyldimethyl ammonium oxide, sodium lauroyl amino acid, cocamidopropyl betaine, cocamidopropyl hydroxysultaine, and lauroyl propyl betaine.
Preferably, the thickener is at least one of sodium chloride, coconut monoethanolamide, polyethylene glycol distearate, cocamide, cetostearyl alcohol, and hydroxyethyl cellulose.
Preferably, the nutritional additive is at least one of soy protein, wheat protein, vitamins and amino acids.
Preferably, the dandruff removing and itching relieving agent is at least one of climbazole, ketoconazole and zinc pyrithione.
Preferably, the hair oil is at least one of dimethicone copolyol, cyclomethicone and dimethicone.
In order to solve the technical problems, the invention provides the following technical scheme: a composition for preventing and improving canities and alopecia is prepared from at least one of eriodictyol, 7-O-methyl eriodictyol, and eriodictyol-7-O-glucoside by mixing, and making into oral liquid.
Preferably, at least one of eriodictyol, 7-O-methyl eriodictyol, and eriodictyol-7-O-glucoside is used as a washing article.
Preferably, the content of at least one of eriodictyol, 7-O-methyl eriodictyol and eriodictyol-7-O-glucoside in the washing product is 0.01-1%, the content of the auxiliary material in the washing product is 30-40%, and the content of the solvent in the washing product is 59-69.99% by mass ratio.
The invention has the beneficial effects that:
(1) The eriodictyol and the derivatives thereof are applied to preventing and improving the white hair and the alopecia, can activate scalp hair follicles and melanocytes, promote the formation of melanin in new hairs and the growth of hairs in a short period, and can effectively improve the problems of the white hair and the alopecia;
(2) The eriodictyol and the derivatives thereof serving as the effective components are derived from natural medicinal materials and other plants, are safe and mild in components, do not stimulate the scalp, do not cause allergic or inflammatory reactions, are suitable for daily use in hair washing and protecting products, and are high in safety and easy to use compared with hair dye products.
Drawings
FIG. 1 is a graph showing the relative melanin content of human epidermal melanocytes in example 1 of the present invention.
Detailed Description
The following description of the preferred embodiments of the present invention is provided for the purpose of illustration and description, and is in no way intended to limit the invention.
Eriodictyol and derivatives thereof, which are flavonoid compounds derived from medicinal materials and plants such as eriodictyol, black nightshade, huai chrysanthemum, honeysuckle, citrus and the like, have obvious effects on the aspects of scavenging free radicals, resisting oxidation, resisting inflammation, resisting bacteria and the like, and can play a plurality of beneficial effects on human health, such as treating Alzheimer disease, resisting diabetes, resisting obesity, protecting the liver and protecting nerves and the heart. It has been reported that 7-O-methyl eriodictyol (Sterubin) can promote melanogenesis by activating WNT signaling pathway and reduce DNA damage of epidermal keratinocytes caused by X-ray irradiation. The patent firstly proposes the application of Eriodictyol and derivatives thereof, namely Eriodictyol (eriodicyol), 7-O-methyl Eriodictyol and Eriodictyol-7-O-glucoside (eriodicyol-7-O-glucoside) in the aspects of preventing and improving white hair and alopecia, and can be used as effective components to be applied to hair products for preventing and improving white hair and alopecia, activate the formation of hair melanin and the growth of hair of human body, and improve and solve the hair problems of the population suffering from hair damage, white hair and alopecia.
The component for preventing and improving the white hair and the alopecia can be at least one of eriodictyol, 7-O-methyl eriodictyol and eriodictyol-7-O-glucoside; also comprises auxiliary materials and solvent.
The adjuvants include, but are not limited to, surfactants, hair pomades, anti-dandruff antipruritics, thickeners, preservatives, nutritional additives, and pH adjusters, and the solvents include, but are not limited to, deionized water, ethanol, propylene glycol, and glycerol.
The surfactant is at least one of hexadecyl trimethyl ammonium chloride, octadecyl trimethyl ammonium chloride, docosyl trimethyl ammonium chloride, dioctadecyl trimethyl ammonium chloride, dodecyl polyoxyethylene, sodium succinate sulfonate, sodium dodecyl sulfate, ammonium dodecyl sulfate, coco glucoside, fatty alcohol polyoxyethylene ether sodium sulfate, lauryl alcohol polyether ammonium sulfate, lauramidopropyl ammonium oxide, dodecyl dimethyl ammonium oxide, sodium lauroyl ammonia, cocamidopropyl betaine, cocamidopropyl hydroxysultaine and lauroyl propyl betaine.
The hair oil is at least one of dimethicone copolyol, cyclomethicone and dimethicone.
The dandruff-removing antipruritic agent is at least one of climbazole, ketoconazole and zinc pyrithione.
The preservative is at least one of cason, phenoxyethanol, benzyl alcohol, sodium benzoate and sodium pyrithione.
The pH regulator is at least one of citric acid and sodium citrate.
The thickener is at least one of sodium chloride, coconut monoethanolamide, polyethylene glycol distearate, cocamide, cetearyl alcohol and hydroxyethyl cellulose.
The nutritional additive is at least one of soybean protein, wheat protein, vitamins and amino acids.
Application of a component for preventing and improving canities and alopecia, at least one of eriodictyol, 7-O-methyl eriodictyol, and eriodictyol-7-O-glucoside can be used for preventing, improving and treating canities or alopecia; at least one of eriodictyol, 7-O-methyl eriodictyol, and eriodictyol-7-O-glucoside can be used as a washing product.
According to the mass ratio, the content of at least one of eriodictyol, 7-O-methyl eriodictyol and eriodictyol-7-O-glucoside in the washing product is 0.01-1%, the content of auxiliary materials in the washing product is 30-40%, and the content of solvent in the washing product is 59-69.99%.
The following components are in mass ratio, and the content of the surfactant in the washing and caring product is 10-25%; the content of the hair moistening grease in the hair washing and/or hair care product is 0.1 to 0.5 percent; the content of the anti-dandruff antipruritic in the hair washing and/or caring product is 0.1-1%; the content of the thickening agent in the hair washing and/or hair care product is 0.2 to 2 percent; the content of the preservative in the hair washing and/or hair care product is 0.1 to 0.5 percent; the content of the nutritional additive in the hair washing and/or hair care product is 1 to 3 percent; the content of the pH regulator in the hair washing and/or hair care product is 0.02-1%.
In the following examples, eriodictyol, 7-O-methyl eriodictyol, eriodictyol-7-O-glucoside, 7,4 '-di-O-methyl eriodictyol, eriodictyol-7, 3' -dimethyl ether, and trimethyl eriodictyol were all commercially available at 98% purity.
Example 1
This example shows the effect of eriodictyol and its derivatives on the promotion of melanin production by cell experiments.
Culturing T25 cell containing human epidermal melanocyteAt 37 ℃ C, 5% CO 2 And standing in a cell culture box with saturated humidity for 3-4 h. Sucking out the culture medium in the culture bottle, and washing the cells once by using the PBS; adding 1mL of 0.25% trypsin digestion solution into the culture bottle, slightly rotating the culture bottle until the digestion solution covers the whole bottom of the culture bottle, sucking out the redundant trypsin digestion solution, and carrying out warm bath at 37 ℃ for 1-3 min; after cell retraction rounding off was observed microscopically, digestion was stopped by adding 5mL of complete medium.
Adjusting the density of human epidermal melanocytes to 1 × 10 5 One cell/mL, 0.5mL per well was inoculated into a 24-well plate, and the medium was added to make the cell density 5X 10 4 Cell/well, at 37 ℃ and 5% CO 2 And culturing for 24 hours in a cell culture box with saturated humidity. The 24-well plate was removed, the medium was aspirated, 1mL of 10 μ M eriodictyol solution prepared from the complete medium (group 01), 10 μ M7-O-methyl eriodictyol solution (group 02), 10 μ M eriodictyol-7-O-glucoside solution (group 03), 10 μ M high eriodictyol solution (group 04), 10 μ M high eriodictyol-7-O-glucoside solution (group 05), 10 μ M7, 4 '-di-O-methyl eriodictyol solution (group 06), 10 μ M eriodictyol-7, 3' -dimethyl ether solution (group 07), and 10 μ M trimethyl eriodictyol solution (group 08) were added to each well of the experimental group, and 1mL of complete medium containing no sample to be tested (group 00) was added to the control group, and the control group was placed in an incubator for culture for 36 hours. After aspirating the medium and washing the cells twice with 1mL of PBS, 100 μ L of PBS solution containing 10% dmso, 1M NaOH was added per well, placed in a water bath at 80 ℃ for 1h in a water bath, the cell eluate from each well of the 24-well plate was transferred to a 96-well plate, the absorbance value of each well was measured at 475nm using a microplate reader, and the relative melanin content of each group was calculated (relative melanin content = absorbance value of cell eluate from each group/absorbance value of cell eluate from control group ×. 100%).
As can be seen from the results in fig. 1, the eriodictyol, 7-O-methyl eriodictyol, and eriodictyol-7-O-glucoside treated cells among the eriodictyol and its derivatives have significantly higher melanin content than the control group and other experimental groups, which indicates that the above components have a better promoting effect on melanin production by human epidermal melanocytes, and the 7-O-methyl eriodictyol has the most significant effect.
Example 2
This example demonstrates the effect of eriodictyol and its derivatives in preventing and ameliorating gray hair by animal experiments.
Selecting 50 inbred line C57BL/6 mice with age of 6 weeks and weight of 18-20 g, cleaning, cutting off long hair in a black hair area on the back of the mice by scissors and shaving off short hair by a shaver, wherein the back of the hair is required to be smooth and not damaged, and the hair removal area is about 2cm multiplied by 2cm. The mice were randomly divided into 5 groups of 10 mice each, each group being a group a: model control group, no medicine is used after molding; group B: a positive control group; group C: eriodictyol treatment group; group D: 7-O-methyl eriodictyol treatment group; group E: eriodictyol-7-O-glucoside treated group. After depilation, the test area was overcoated with 2.5% hydroquinone solution 2 times a day for 30 days with 1mL each time to prepare a mouse white hair model. After the model building is successful, the group B is coated with methoxsalen for 1 time every day, and the groups C, D and E are coated with 0.1% (w/v) eriodictyol solution, 0.1% (w/v) 7-O-methyl eriodictyol solution and 0.1% (w/v) eriodictyol-7-O-glucoside solution (dissolved in 50% ethanol) for 0.2mL each time for 30 days continuously.
After the experiment, the hair restoration effect of the test area of each group of mice is observed and scored. The criteria are as follows: the percentage of the hairs in the test area which are all white and have no black is 0 score, the percentage of the hairs in the test area which are newly grown and black is 0-25% is 1 score, the percentage of the hairs in the test area which are newly grown and black is 25-50% is 2 score, the percentage of the hairs in the test area which are newly grown and black is 50-75% is 3 score, and the percentage of the hairs in the test area which are newly grown and black is 75-100% is 4 score.
After the experiment is finished, three mice are randomly selected from each group, skin tissues of a tested area with a proper size are cut to be pathological sections, the pathological sections are fixed by using 10% formaldehyde, dehydrated, embedded in paraffin, sliced, subjected to HE staining, sealed by using neutral gum, and the skin tissue condition and the proportion of melanin-containing hair follicles are observed under a light mirror (60 hair follicles are observed at random and counted).
TABLE 1 Hair restoration score for each group of mice in test area
| Group of | Scoring |
| Group A | 1.5 |
| Group B | 3.7 |
| Group C | 2.9 |
| Group D | 3.5 |
| Group E | 3.2 |
The results in table 1 show that the scores of the new black hair of mice treated with eriodictyol, 7-O-methyl eriodictyol and eriodictyol-7-O-glucoside after molding are obviously higher than those of the model control group and close to the level of the positive control group, which indicates that the components can effectively recover the generation of hair melanin and have certain functions of preventing and improving white hair.
TABLE 2 Hair follicle status of skin tissue of mice in each group
| Group of | Melanin-containing hair follicle ratio (%) |
| Group A | 34.44±4.19 |
| Group B | 85.56±5.09 |
| Group C | 80.56±5.09 |
| Group D | 85.00±7.64 |
| Group E | 81.11±6.31 |
The results of light microscope observation show that the test areas of the mice in groups C, D and E have complete covered squamous epithelium structure, no thickening of the cornified layer, no blood vessel dilatation and congestion in the dermis, inflammatory cell infiltration and the like, which indicates that the skin tissues of the mice are not negatively influenced by the treatment of the eriodictyol, the 7-O-methyl eriodictyol and the eriodictyol-7-O-glucoside, and the components are mild, have no stimulation and have high safety. The results in table 2 show that the proportion of melanin-containing hair follicles in the skin tissues of the mice treated with eriodictyol, 7-O-methyl eriodictyol and eriodictyol-7-O-glucoside after molding is obviously higher than that of the model control group and close to the level of the positive control group, which indicates that the components can effectively recover the generation of melanin in the hair follicles, and have certain functions of preventing and improving white hair.
Example 3
This example demonstrates the effect of eriodictyol and its derivatives in preventing and ameliorating hair loss by animal experiments.
Selecting 50 inbred line C57BL/6 mice with age of 6 weeks and weight of 18-20 g, cleaning, cutting off long hair in a black hair area on the back of the mice by using a pair of scissors and shaving off short hair by using a shaver, wherein the back of the depilated mice is required to be smooth and not damaged, and the depilated area is about 2cm multiplied by 2cm. 0.6mL of 6% Na was aspirated using a 1mL syringe 2 S solution is evenly smeared on a tested area on the back of the mouse to be testedThe hair on the back of the area turns to light yellow, and the back is cleaned by warm water and kept dry. The mice were randomly divided into 5 groups of 10 mice each, each group being a group a: model control group, no medicine is used after molding; group B: a positive control group; group C: eriodictyol treatment group; group D: 7-O-methyl eriodictyol treatment group; group E: eriodictyol-7-O-glucoside treated group. After depilation, each group was topically applied to the test area with 5% imiquimod ointment at an amount of 0.1 g/mouse 4 times per week, and the skin on the back was cleaned with physiological saline before administration to remove the residual drug on the previous time until the skin on the back of the mouse appeared slightly horny and reddish, and the administration was stopped to prepare a mouse alopecia model. After the model building is successful, the minoxidil tincture is respectively applied to the group B for 1 time every day, and the eriodictyol solution of 0.1% (w/v), the 7-O-methyl eriodictyol solution of 0.1% (w/v) and the eriodictyol-7-O-glucoside solution of 0.1% (w/v) are respectively applied to the groups C, D and E for 1 time every day, and 0.2mL of the solutions are continuously applied for 30 days.
After the experiment, the hair growth of each group of mice was scored according to the following criteria: the hair does not grow, the skin color of the depilatory area is '0 min', the skin color of the depilatory area is '1 min', the skin color of the depilatory area is '2 min', the skin color of the depilatory area is black, a few hairs grow out to be '3 min', the density and length of new hairs are about 1/2 of the density and length of the non-depilatory area to be '4 min', and the density and length of the new hairs are consistent with those of the non-depilatory area to be '5 min'.
After the experiment is finished, the hair in the longer area of the hair is pulled out by tweezers in the tested area of each group of mice, and the longest three of the hair are selected for measuring the length. The hair density was calculated as the average weight of each group of mouse hairs by cutting a 2cm × 2cm area of new hair along the hair root with scissors, weighing the hair using an analytical balance, and calculating the hair density as the hair weight/hair length.
TABLE 3 groups of mice Hair growth Scoring
As can be seen from the results in Table 3, the hair growth scores of the mice treated with eriodictyol, 7-O-methyl eriodictyol and eriodictyol-7-O-glucoside after molding are obviously higher than those of the model control group and are close to the positive control group, which indicates that the components can effectively recover the hair growth and have certain effects of preventing and improving alopecia.
TABLE 4 detection of Hair growth in groups of mice
| Group of | Wool length (mm) | Gross weight (mg) | Wool density |
| Group A | 2.39±0.34 | 5.54±0.31 | 2.32 |
| Group B | 6.61±0.39 | 16.72±0.60 | 2.53 |
| Group C | 6.30±0.40 | 15.37±0.56 | 2.44 |
| Group D | 6.51±0.38 | 16.35±0.56 | 2.51 |
| Group E | 6.42±0.39 | 15.80±0.76 | 2.46 |
From the results in table 4, it can be seen that the hair length, hair weight and hair density of the mice treated with eriodictyol, 7-O-methyl eriodictyol and eriodictyol-7-O-glucoside after molding were significantly higher than those of the model control group, and were close to those of the positive control group, which also indicates that the above components can effectively restore hair growth and have certain effects of preventing and improving alopecia.
The above embodiments are preferred embodiments of the present invention, and those skilled in the art can make variations and modifications to the above embodiments, therefore, the present invention is not limited to the above embodiments, and any obvious improvements, substitutions or modifications made by those skilled in the art based on the present invention are within the protection scope of the present invention.
Claims (10)
1. A composition for preventing and improving gray hair and alopecia is characterized by comprising at least one of eriodictyol, 7-O-methyl eriodictyol, and eriodictyol-7-O-glucoside.
2. The composition for preventing and improving gray hair and alopecia as claimed in claim 1, further comprising adjuvants including but not limited to surfactants, hair pomades, anti-dandruff antipruritics, thickeners, preservatives, nutritional additives and pH adjusting agents, and solvents including but not limited to deionized water, ethanol, propylene glycol and glycerin.
3. The component for preventing and improving canities and alopecias according to claim 2, wherein said surfactant is at least one of cetyltrimethylammonium chloride, octadecyltrimethylammonium chloride, docosyltrimethylammonium chloride, dioctadecyltrimethylammonium chloride, dodecyldipolyoxyethylene, sodium sulfosuccinate, sodium dodecylsulfate, ammonium dodecylsulfate, cocoglucoside, sodium fatty alcohol-polyoxyethylene ether sulfate, sodium laureth sulfate, ammonium laureth sulfate, lauramidopropyl ammonium oxide, dodecyldimethylammonium oxide, sodium lauroyl amino acid, cocoamidopropyl betaine, cocoamidopropyl hydroxysultaine, and lauroyl propyl betaine.
4. The composition for preventing and improving gray hair and alopecia according to claim 2, wherein the thickener is at least one of sodium chloride, coconut monoethanolamide, polyethylene glycol distearate, cocamide, cetearyl alcohol, and hydroxyethyl cellulose.
5. The composition for preventing and improving gray hair and alopecia according to claim 2, wherein the nutritional supplement is at least one of soy protein, wheat protein, vitamins, and amino acids.
6. The composition for preventing and ameliorating gray hair and alopecia of claim 2, wherein said dandruff-removing and antipruritic agent is at least one selected from the group consisting of climbazole, ketoconazole, and zinc pyrithione.
7. The composition for preventing and ameliorating canities and alopecia according to claim 2, wherein the hair tonic is at least one of dimethicone copolyol, cyclomethicone, and dimethicone.
8. The use of a composition for preventing and ameliorating gray hair and alopecia, wherein at least one of eriodictyol, 7-O-methyl eriodictyol, and eriodictyol-7-O-glucoside can be used for preventing, ameliorating, and treating gray hair or alopecia.
9. The use of the composition for preventing and improving gray hair and alopecia according to claim 8, wherein at least one of eriodictyol, 7-O-methyl eriodictyol, and eriodictyol-7-O-glucoside is used as a washing product.
10. The use of the composition for preventing and improving gray hair and alopecia according to claim 8, wherein the content of at least one of eriodictyol, 7-O-methyl eriodictyol, and eriodictyol-7-O-glucoside in the washing and care product is 0.01 to 1%, the content of the auxiliary material in the washing and care product is 30 to 40%, and the content of the solvent in the washing and care product is 59 to 69.99% by mass.
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Citations (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5792448A (en) * | 1994-05-05 | 1998-08-11 | L'oreal | Use of flavonoids for preserving and/or enhancing the mechanical properties of the hair and process for protecting the hair using these compounds |
| CN1893909A (en) * | 2003-12-18 | 2007-01-10 | 雀巢技术公司 | Composition for improving skin, hair and coat health containing flavanones |
| JP2010285394A (en) * | 2009-06-12 | 2010-12-24 | Hoyu Co Ltd | Hair treatment composition |
| WO2013094282A1 (en) * | 2011-12-22 | 2013-06-27 | ホーユー株式会社 | External preparation composition for skin and hair, and non-therapeutic cosmetic method |
| JP2013147491A (en) * | 2011-12-22 | 2013-08-01 | Hoyu Co Ltd | Agent for controlling the number of gray hair and nontherapeutic beauty method |
| CN103987369A (en) * | 2011-12-12 | 2014-08-13 | 荷兰联合利华有限公司 | Method of strengthening hair fibres |
| KR20150023607A (en) * | 2015-02-03 | 2015-03-05 | 연세대학교 원주산학협력단 | Pharmaceutical composition comprising eriodictyol or its pharmaceutically acceptable salts as an active ingredient for preventing or treating contact dermatitis |
| US20180344603A1 (en) * | 2015-11-13 | 2018-12-06 | Conopco, Inc., D/B/A Unilever | Composition for hair follicle growth |
| CN109069385A (en) * | 2016-05-13 | 2018-12-21 | 株式会社Nil | Trichochromes reinforcing agent |
-
2022
- 2022-09-13 CN CN202211107565.0A patent/CN115300409A/en active Pending
Patent Citations (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5792448A (en) * | 1994-05-05 | 1998-08-11 | L'oreal | Use of flavonoids for preserving and/or enhancing the mechanical properties of the hair and process for protecting the hair using these compounds |
| CN1893909A (en) * | 2003-12-18 | 2007-01-10 | 雀巢技术公司 | Composition for improving skin, hair and coat health containing flavanones |
| JP2010285394A (en) * | 2009-06-12 | 2010-12-24 | Hoyu Co Ltd | Hair treatment composition |
| CN103987369A (en) * | 2011-12-12 | 2014-08-13 | 荷兰联合利华有限公司 | Method of strengthening hair fibres |
| WO2013094282A1 (en) * | 2011-12-22 | 2013-06-27 | ホーユー株式会社 | External preparation composition for skin and hair, and non-therapeutic cosmetic method |
| JP2013147491A (en) * | 2011-12-22 | 2013-08-01 | Hoyu Co Ltd | Agent for controlling the number of gray hair and nontherapeutic beauty method |
| KR20150023607A (en) * | 2015-02-03 | 2015-03-05 | 연세대학교 원주산학협력단 | Pharmaceutical composition comprising eriodictyol or its pharmaceutically acceptable salts as an active ingredient for preventing or treating contact dermatitis |
| US20180344603A1 (en) * | 2015-11-13 | 2018-12-06 | Conopco, Inc., D/B/A Unilever | Composition for hair follicle growth |
| CN109069385A (en) * | 2016-05-13 | 2018-12-21 | 株式会社Nil | Trichochromes reinforcing agent |
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