CN115282101B - Pet bath lotion for reducing stress response of cats and preparation method thereof - Google Patents
Pet bath lotion for reducing stress response of cats and preparation method thereof Download PDFInfo
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- CN115282101B CN115282101B CN202210767937.6A CN202210767937A CN115282101B CN 115282101 B CN115282101 B CN 115282101B CN 202210767937 A CN202210767937 A CN 202210767937A CN 115282101 B CN115282101 B CN 115282101B
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Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
- A61K8/9783—Angiosperms [Magnoliophyta]
- A61K8/9794—Liliopsida [monocotyledons]
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/40—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing nitrogen
- A61K8/44—Aminocarboxylic acids or derivatives thereof, e.g. aminocarboxylic acids containing sulfur; Salts; Esters or N-acylated derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/92—Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof
- A61K8/922—Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof of vegetable origin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
- A61K8/9783—Angiosperms [Magnoliophyta]
- A61K8/9789—Magnoliopsida [dicotyledons]
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P39/00—General protective or antinoxious agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q17/00—Barrier preparations; Preparations brought into direct contact with the skin for affording protection against external influences, e.g. sunlight, X-rays or other harmful rays, corrosive materials, bacteria or insect stings
- A61Q17/005—Antimicrobial preparations
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/10—Washing or bathing preparations
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61Q5/00—Preparations for care of the hair
- A61Q5/12—Preparations containing hair conditioners
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- A—HUMAN NECESSITIES
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Landscapes
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- Life Sciences & Earth Sciences (AREA)
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- Engineering & Computer Science (AREA)
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- Toxicology (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Cosmetics (AREA)
Abstract
The invention relates to a pet bath lotion for reducing cat stress reaction and a preparation method thereof, wherein the pet bath lotion for reducing cat stress reaction comprises a conditioner, a humectant, an emulsifier, a thickener, a pH regulator and water; the conditioner comprises an extract of Actinidia polygama, an extract of catnip, an extract of Verbena officinalis, an extract of calendula officinalis and an extract of Cymbopogon citratus. The five conditioner components complement each other and synergistically increase, and the hair conditioner has remarkable effects in relieving the emotion of the cat, reducing the stress response of the cat, inhibiting bacteria and diminishing inflammation and caring hair.
Description
Technical Field
The invention belongs to the technical field of daily chemical products for pets, relates to pet bath cream for reducing cat stress reaction and a preparation method thereof, and particularly relates to pet bath cream with the effects of reducing cat stress reaction, inhibiting bacteria, diminishing inflammation and caring hair and a preparation method thereof.
Background
Stress is a series of changes in the body of an animal due to external stimuli, such as increased secretion of various hormones, increased blood pressure, increased blood glucose, etc. Stress may occur in every organism, but only because cats are naturally very small, they are more sensitive to external stimuli, and thus they are more prone to stress.
The cat is very biliary and small sensitive animal, is very sensitive to strange environment, and the smell of the cat is very sensitive, and the new environment and smell are changed from the original environment, so that the cat is more uneasy. The cat is not frightened, and the strong stress response of the cat can be caused by one-time going out and one-time bathing.
When the cat is stressed, the following changes can be generated in physiology: hair frying, mydriasis, shortness of breath, tachycardia, running water, slow growth of young cats, and the like. Behavior change: stiff, escaping, hiding, fizzing, cat paging, excessive hair grooming, etc. Most often frightened, lying alone under the bed, under the sofa, etc. for a long time. The serious points are vomiting, diarrhea and constipation. However, if the patient is frequently put into the toilet, the patient can not get out of the toilet due to constipation or urine. Even worse, it is shown that the food is not eaten for several consecutive days and howling is not found. The most serious is general cramps, rapid abdominal relief, eye relief, death at the time of or shortly after the stress.
There are many sequelae of stress, which remain after the symptoms are relieved by treatment and threaten the health of the cat. For example, a too long blockage of the urethra may result in severe postrenal failure, which is a serious life-threatening problem. If the cat does not eat for a long time, the organism can decompose a large number of fat cells, and the fat cells are deposited in the liver to cause fatty liver, and the fatty liver can adversely affect the appetite of the cat, so that the cat does not eat and is in vicious circle. We need to be particularly careful in the face of stress response to cats.
The hair of the pet is relatively long, and is easy to dirty, and needs to be cleaned regularly. Some pets feel dirty on the cat body, so the cat is often helped to take a bath, but a lot of pet shampoos only pay attention to basic cleaning functions, lack hair and skin care components, and the use of the shampoo for frequent bathing of the cat easily causes the damage of the grease protection layer on the skin of the cat, so that the cat has the phenomena of hair loss, tear marks and the like, and even suffers from skin diseases. In addition, the hair and skin of the pet cat are rich in bacteria and fungi, and are easy to suffer from skin diseases, and particularly the hair and skin of the pet cat are easy to be infected by fungi and tinea. At present, the pet breeding is very common, and the nursing products of the pet, such as the bath cream in the aspect of cleaning, are more and more paid attention to the comprehensiveness of the quality and the efficacy of the products. The specific cat stress reaction resistant functional pet bath cream disclosed in the prior art is still few.
Disclosure of Invention
Aiming at the defects of the prior art, the invention aims to provide the pet bath lotion for reducing the stress response of cats and the preparation method thereof, and particularly provides the pet bath lotion with the effects of reducing the stress response of cats, inhibiting bacteria, diminishing inflammation and caring hair and the preparation method thereof.
In order to achieve the aim of the invention, the invention adopts the following technical scheme:
In a first aspect, the present invention provides a pet body wash for reducing cat stress comprising a conditioning agent, a humectant, an emulsifier, a thickener, a pH adjuster, and water;
the conditioner comprises an extract of Actinidia polygama, an extract of catnip, an extract of Verbena officinalis, an extract of calendula officinalis and an extract of Cymbopogon citratus.
Five conditioner components including the ramulus et folium Actinidiae Polygamae extract, the catnip extract, the verbena extract, the calendula extract and the lemon grass extract are simultaneously added into the pet bath cream, wherein the ramulus et folium Actinidiae Polygamae extract and the catnip extract both contain nepetalactone, so that the emotion of a cat can be relieved, the stress response of the cat can be reduced, and the pet bath cream also has good effects of hair care, antibiosis and antipruritic, mosquito expelling, cat moss removing and the like; wherein, the verbena extract, the calendula extract and the lemon grass extract are extracted from the favorite plants of the cat, and all have unique fragrant substances, so that the cat feels comfortable and pleasant, the emotion of the cat is alleviated, the stress response of the cat is reduced, the anti-inflammatory and antibacterial effects are good, certain auxiliary effects are provided for the cat, and the skin of the cat can be nourished. The five components complement each other and synergistically increase, and the composition has remarkable effects in relieving the emotion of the cat, reducing the stress response of the cat, inhibiting bacteria, diminishing inflammation and caring hair.
Preferably, the pet bath cream for reducing cat stress reaction comprises, by weight, 5-30 parts of a conditioning agent, 0.1-10 parts of a humectant, 25-60 parts of an emulsifying agent, 5-30 parts of a thickening agent, 0.01-0.2 part of a pH regulator and water;
The conditioner comprises, by weight, 1-10 parts of a polyghace seche extract, 1-10 parts of a catmint extract, 1-10 parts of a verbena extract, 1-10 parts of a calendula extract and 1-10 parts of a lemon grass extract.
When the five conditioner components of the polygonum simplicissima lour extract, the catnip extract, the verbena extract, the calendula extract and the lemon grass extract are matched with other conventional components in the bath foam according to the specific mass ratio, the effects of relieving the emotion of the cat, reducing the stress response of the cat, inhibiting bacteria, diminishing inflammation and caring hair are more remarkable.
The conditioning agent may be 5 parts, 8 parts, 10 parts, 12 parts, 15 parts, 18 parts, 20 parts, 22 parts, 25 parts, 28 parts, 30 parts, etc. by weight.
The humectant may be 0.1 part, 1 part, 2 parts, 3 parts, 4 parts, 5 parts, 6 parts, 7 parts, 8 parts, 9 parts, 10 parts, etc.
The weight parts of the emulsifier may be 25 parts, 30 parts, 35 parts, 40 parts, 45 parts, 50 parts, 55 parts, 60 parts, etc.
The weight parts of the thickener may be 5 parts, 8 parts, 10 parts, 12 parts, 15 parts, 18 parts, 20 parts, 22 parts, 25 parts, 28 parts, 30 parts, etc.
The weight parts of the pH adjuster may be 0.01 part, 0.03 part, 0.05 part, 0.08 part, 0.1 part, 0.12 part, 0.15 part, 0.17 part, 0.2 part, and the like.
The parts by weight of the polygonum multiflorum extract, catnip extract, verbena extract, calendula extract and lemon grass extract are each independently selected from 1 part, 2 parts, 3 parts, 4 parts, 5 parts, 6 parts, 7 parts, 8 parts, 9 parts, 10 parts and the like.
Other specific point values in the numerical ranges are selectable, and will not be described in detail herein.
Preferably, the conditioning agent further comprises thyme oil and rosemary oil.
The invention also creatively discovers that the thyme oil and the rosemary oil are further added into the bath foam, so that the bath foam can promote the effects of relieving the emotion of the cat, reducing the stress response of the cat, inhibiting bacteria, diminishing inflammation and caring hair. And thyme oil and rosemary oil have a certain synergistic effect.
Preferably, the conditioner also comprises 0.1-1 part by weight of thyme oil and 0.1-1 part by weight of rosemary oil.
The thyme oil and the rosemary oil are each independently selected from 0.1 part, 0.2 part, 0.3 part, 0.4 part, 0.5 part, 0.6 part, 0.7 part, 0.8 part, 0.9 part, 1 part, and the like.
Other specific point values in the numerical ranges are selectable, and will not be described in detail herein.
Further preferably, the conditioning agent further comprises gamma-aminobutyric acid.
The invention also creatively discovers that the effect of the bath lotion in relieving the emotion of the cat and reducing the stress response of the cat can be promoted by further adding the gamma-aminobutyric acid into the bath lotion.
Preferably, the conditioning agent further comprises 0.01-1 part by weight of gamma-aminobutyric acid, for example 0.01 part, 0.05 part, 0.1 part, 0.2 part, 0.3 part, 0.4 part, 0.5 part, 0.6 part, 0.7 part, 0.8 part, 0.9 part, 1 part, etc. Other specific point values within the numerical range can be selected, and will not be described in detail herein.
Preferably, the humectant comprises any one or a combination of at least two of phytosterols, hydrolyzed wheat protein, and hydrolyzed fibroin.
Preferably, the emulsifier comprises any one or a combination of at least two of sodium cocoamidopropionate, cocamidopropyl betaine, cocamidomethyl MEA, sodium cocoisethionate, and vegetable alkyl glycoside. Preferred are combinations of sodium cocoamidopropionate, cocoamidopropyl betaine, cocoamidomethyl MEA, sodium cocoisethionate, and vegetable alkyl glycosides.
The pet bath lotion system disclosed by the invention takes sodium cocoamidopropionate and cocamidopropyl betaine as main surface active agents, and cocamidomethyl MEA, sodium cocoyl isethionate and plant alkyl glycoside as auxiliary surface active agents, and the five are matched, so that the pet bath lotion system has good effects of bubbling and stabilizing bubbles and cleaning pet fur, and is low in degreasing force, low in irritation, mild and non-irritating, and capable of enabling a cat to feel comfortable and pleasant, relieving the emotion of the cat and reducing stress reaction of the cat; the synergistic conditioner promotes the moisturizing and antibacterial effects of the shower gel.
Preferably, the thickener comprises any one or a combination of at least two of lauramidopropyl hydroxysulfobetaine, cationic guar, sodium chloride, 16-18 alcohol, lauryl alcohol, myristyl alcohol, linoleic acid, linolenic acid.
Preferably, the pH adjuster comprises citric acid and/or sodium citrate.
Preferably, the pet bath cream for reducing cat stress reaction further comprises any one or a combination of two of a chelating agent and a preservative.
Preferably, the chelating agent comprises disodium edetate.
Preferably, the pet bath cream for reducing cat stress reaction further comprises any one or a combination of at least two of 0.01-0.5 part of chelating agent and 0.1-1 part of preservative in parts by weight.
The chelating agent may be 0.01 part, 0.05 part, 0.1 part, 0.15 part, 0.2 part, 0.25 part, 0.3 part, 0.35 part, 0.4 part, 0.45 part, 0.5 part, etc.
The preservative may be 0.1 part, 0.2 part, 0.3 part, 0.4 part, 0.5 part, 0.6 part, 0.7 part, 0.8 part, 0.9 part, 1 part, etc.
Other specific point values in the numerical ranges are selectable, and will not be described in detail herein.
In a second aspect, the present invention provides a method for preparing the pet body wash for reducing cat stress according to the first aspect, the method comprising:
(1) Mixing an emulsifying agent with water to obtain a first mixed solution;
(2) And mixing the first mixed solution with a conditioner, a thickener, a humectant and a pH regulator.
The pet bath gel provided by the invention has the advantages of simple preparation process, convenience in operation, lower cost, suitability for industrial production and high practicability.
Preferably, the water of step (1) is mixed with the chelating agent prior to mixing with the emulsifier.
Preferably, the mixing in step (2) is followed by mixing with a preservative.
Preferably, the temperature of the mixing in step (1) is 80-85 ℃, e.g. 80 ℃, 81 ℃, 82 ℃, 83 ℃, 84 ℃, 85 ℃, etc.; the mixing time is 5-20min, such as 5min, 8min, 10min, 12min, 15min, 18min, 20min, etc.
Preferably, the temperature of the mixing in step (2) is 40-60 ℃, e.g. 40 ℃, 42 ℃, 45 ℃, 50 ℃, 55 ℃, 58 ℃, 60 ℃, etc.; the mixing time is 5-20min, such as 5min, 8min, 10min, 12min, 15min, 18min, 20min, etc.
Compared with the prior art, the invention has the following beneficial effects:
Five conditioner components including the ramulus et folium Actinidiae Polygamae extract, the catnip extract, the verbena extract, the calendula extract and the lemon grass extract are simultaneously added into the pet bath cream, wherein the ramulus et folium Actinidiae Polygamae extract and the catnip extract both contain nepetalactone, so that the emotion of a cat can be relieved, the stress response of the cat can be reduced, and the pet bath cream also has good effects of hair care, antibiosis and antipruritic, mosquito expelling, cat moss removing and the like; wherein, the verbena extract, the calendula extract and the lemon grass extract are extracted from the favorite plants of the cat, and all have unique fragrant substances, so that the cat feels comfortable and pleasant, the emotion of the cat is alleviated, the stress response of the cat is reduced, the anti-inflammatory and antibacterial effects are good, certain auxiliary effects are provided for the cat, and the skin of the cat can be nourished. The five components complement each other and synergistically increase, and the composition has remarkable effects in relieving the emotion of the cat, reducing the stress response of the cat, inhibiting bacteria, diminishing inflammation and caring hair.
The invention also creatively discovers that the thyme oil and the rosemary oil are further added into the bath foam, so that the bath foam can promote the effects of relieving the emotion of the cat, reducing the stress response of the cat, inhibiting bacteria, diminishing inflammation and caring hair. And thyme oil and rosemary oil have a certain synergistic effect. The thyme oil and the rosemary oil are used for replacing the chemical flavoring agent, so that the toxic and side effects of the chemical flavoring agent on the cat can be avoided.
The invention also creatively discovers that the effect of the bath lotion in relieving the emotion of the cat and reducing the stress response of the cat can be promoted by further adding the gamma-aminobutyric acid into the bath lotion.
Detailed Description
In order to further describe the technical means adopted by the present invention and the effects thereof, the following describes the technical scheme of the present invention in combination with the preferred embodiments of the present invention, but the present invention is not limited to the scope of the embodiments.
The raw material source information related to the following examples and comparative examples is shown in the following table:
Example 1
The embodiment provides pet bath cream for reducing cat stress response, which comprises the following components in percentage by weight:
Conditioning agents (5% of polygonum multiflorum extract, 3% of catnip extract, 2% of verbena extract, 6% of calendula extract, 8% of lemon grass extract, 0.3% of thyme oil, 0.2% of rosemary oil, 0.1% of gamma-aminobutyric acid), humectants (1% of phytosterols), emulsifiers (9% of sodium cocoamidopropionate, 6% of cocamidopropyl betaine, 2% of cocamidomethyl MEA, 1% of sodium cocoisethionate, 2% of plant alkyl glycosides), thickeners (10% of lauramidopropyl hydroxysulfobetaine), 0.5% of cationic guar gum, pH adjusting agent (citric acid, adjusting system to ph=6.5), chelating agents (EDTA 2Na 0.1%) and water make up to 100%.
The preparation method comprises the following steps:
(1) Mixing water with EDTA 2Na, and then mixing with an emulsifier at 80 ℃ for 15min to obtain a first mixed solution;
(2) Mixing the first mixed solution with a conditioner, a thickener, a humectant and a pH regulator, and stirring at 50deg.C for 15 min.
Example 2
The embodiment provides pet bath cream for reducing cat stress response, which comprises the following components in percentage by weight:
Conditioning agents (7% of polygonum multiflorum extract, 1% of catnip extract, 6% of verbena extract, 8% of calendula extract, 2% of lemon grass extract, 0.1% of thyme oil, 0.4% of rosemary oil, 0.1% of gamma-aminobutyric acid), humectants (1% of phytosterols), emulsifiers (12% of sodium cocoamidopropionate, 3% of cocamidopropyl betaine, 4% of cocamidomethyl MEA, 0.5% of sodium cocoisethionate, 0.5% of plant alkyl glycoside), thickeners (10% of lauramidopropyl hydroxysulfobetaine), 0.5% of cationic guar gum, pH adjusting agents (citric acid, adjusting system to ph=6.5), chelating agents (EDTA 2Na 0.1%) and water to 100%.
The preparation method comprises the following steps:
(1) Mixing water with EDTA 2Na, and then mixing with an emulsifier at 70 ℃ for 20min to obtain a first mixed solution;
(2) Mixing the first mixed solution with conditioner, thickener, humectant and pH regulator, and stirring at 40deg.C for 20 min.
Comparative example 1
This comparative example provides a pet bath lotion for reducing cat stress, which is different from example 1 only in that it lacks the ingredients of the extract of Actinidia polygama, and the mass of the ingredients is proportionally distributed on the mass of the catnip extract, the verbena extract, the calendula extract, the lemon grass extract, and the other ingredients and the content thereof remain unchanged. The preparation method is described in example 1.
Comparative example 2
This comparative example provides a pet bath lotion for reducing cat stress, which is different from example 1 only in that the catmint extract component is absent, and the weight of the catmint extract component is apportioned to the weight of the polygonum multiflorum extract, the verbena extract, the calendula extract and the lemon grass extract, and the other components and the content thereof are kept unchanged. The preparation method is described in example 1.
Comparative example 3
This comparative example provides a pet bath lotion for reducing cat stress, which is different from example 1 only in that the formulation lacks the verbena extract component, and the mass thereof is proportionally distributed on the masses of the polygonum simplicissima extract, the catnip extract, the calendula extract and the lemon grass extract, and the other components and the content thereof are kept unchanged. The preparation method is described in example 1.
Comparative example 4
This comparative example provides a pet bath lotion for reducing cat stress, which is different from example 1 only in that calendula extract components are absent, and the mass of the calendula extract components is proportionally distributed on the mass of the polygonum simplicissima extract, the catnip extract, the verbena extract and the lemon grass extract, and other components and the content of the calendula extract components are kept unchanged. The preparation method is described in example 1.
Comparative example 5
This comparative example provides a pet bath lotion for reducing cat stress, which is different from example 1 only in that the lemon grass extract component is absent, and the quality thereof is proportionally distributed on the quality of the polygonum simplicissima extract, the catnip extract, the verbena extract and the calendula extract, and the other components and the content thereof are kept unchanged. The preparation method is described in example 1.
Comparative example 6
This comparative example provides a pet bath lotion for reducing cat stress, which is different from example 1 in the formulation in that 5% of the ramulus et folium Actinidiae Polygamae extract, 3% of the catnip extract, 2% of the herba Verbenae extract, 6% of the calendula extract, 8% of the herba Cymbopogonis Citrari extract is replaced by 24% of the ramulus et folium Actinidiae Polygamae extract, and the other components and their contents remain unchanged. The preparation method is described in example 1.
Comparative example 7
This comparative example provides a pet bath lotion for reducing cat stress, which is different from example 1 in the formulation only in that 5% of the knotweed extract, 3% of the catnip extract, 2% of the verbena extract, 6% of the calendula extract, 8% of the lemon grass extract are replaced by 24% of the catnip extract, and the other components and the content thereof remain unchanged. The preparation method is described in example 1.
Comparative example 8
This comparative example provides a pet bath lotion for reducing cat stress, which is different from example 1 in the formulation only in that 5% of the knotweed extract, 3% of the catnip extract, 2% of the verbena extract, 6% of the calendula extract, 8% of the lemon grass extract are replaced by 24% of the verbena extract, and the other components and the content thereof remain unchanged. The preparation method is described in example 1.
Comparative example 9
This comparative example provides a pet bath lotion for reducing cat stress, which is different from example 1 in the formulation only in that 5% of the knotweed extract, 3% of the catnip extract, 2% of the verbena extract, 6% of the calendula extract, 8% of the lemon grass extract are replaced by 24% of the calendula extract, and the other components and the content thereof remain unchanged. The preparation method is described in example 1.
Comparative example 10
This comparative example provides a pet bath lotion for reducing cat stress, which is different from example 1 in the formulation only in that 5% of the knotweed extract, 3% of the catnip extract, 2% of the verbena extract, 6% of the calendula extract, 8% of the lemon grass extract are replaced by 24% of the lemon grass extract, and the other components and the content thereof remain unchanged. The preparation method is described in example 1.
Example 3
The formulation of the pet bath cream for reducing cat stress reaction is different from that of the example 1 only in that thyme oil 0.3% and rosemary oil 0.2% are replaced by thyme oil 0.5%, and other components and contents thereof are kept unchanged. The preparation method is described in example 1.
Example 4
The formulation of the pet bath cream for reducing cat stress reaction is different from that of the example 1 only in that 0.3% of thyme oil and 0.2% of rosemary oil are replaced by 0.5% of rosemary oil, and other components and contents thereof are kept unchanged. The preparation method is described in example 1.
Example 5
This example provides a pet body wash for reducing cat stress, which differs from example 1 only in the lack of gamma-aminobutyric acid components, other components and their content. The preparation method is described in example 1.
Example 6
The present example provides a pet bath lotion for reducing cat stress, which differs from example 1 only in that thyme oil, rosemary oil, gamma-aminobutyric acid components are absent, and other components and contents thereof remain unchanged. The preparation method is described in example 1.
Test example 1
Safety evaluation was performed on the body wash products prepared in examples 1 to 6:
(1) Erythrocyte hemolysis test
Preparation of erythrocyte suspensions: healthy rabbits are selected, 9mL of heart blood is taken, 1mL of 2% potassium oxalate solution is added, centrifugation is carried out, supernatant fluid is removed, 20mmol/L PBS solution is used for diluting sediment to 20mL, and the sediment is preserved at 4 ℃ for standby. Each set of samples was selected to be diluted with PBS solution to different concentrations, each sample being set with 5 concentration gradients. Taking 10mL of a diluent of a sample to be detected, adding 200 mu L of the erythrocyte suspension (controlling the final concentration of the sample to be 5, 10, 20, 50 and 100mg/mL respectively), taking distilled water as a total hemolysis control, taking a PBS solution as a negative control, gently mixing, incubating for 30min at 37 ℃, centrifuging for 10min at a rotating speed of 2000r/min, taking a supernatant, testing the absorbance (A560) of the supernatant at 560nm by using a spectrophotometer, and calculating the hemolysis rate according to the following formula;
Hemolysis ratio= [ (experimental group A560 -negative control group A560)/(total hemolysis control group A560 -negative control group A560) ]. Times.100%
The standard curve of the hemolysis rate-sample concentration was drawn, and the sample concentration (HD 50) at which 50% of the erythrocytes were hemolyzed was calculated.
(2) Protein denaturation assay
Diluting each group of samples to 10g/L by using PBS solution, taking 10mL of diluent of the sample to be detected, adding 200 mu L of the erythrocyte suspension, taking distilled water as a blank control, taking 1mg/mL Sodium Dodecyl Sulfate (SDS) solution as a positive control, gently mixing, incubating for 30min at 37 ℃, centrifuging for 10min at the rotating speed of 2000r/min, taking supernatant, respectively testing the absorbance A540 and A575 at 540nm and 575nm by using a spectrophotometer, and calculating protein Denaturation Index (DI) according to the following formula;
DI=[(R1-R2)/(R1-R3)]×100%
wherein, R 1 = blank control group a 575/blank control group a 540,R2 = experimental group a 575/experimental group a 540,R3 = positive control group a 575/positive control group a 540.
The irritation of the sample to be tested was evaluated based on the L/D value, which is HD50/DI, and the irritation grading criteria are shown in Table 1 below:
TABLE 1
L/D | Grading |
>100 | No irritation |
10<L/D≤100 | Microstimulation |
1<L/D≤10 | Mild irritation |
0.1<L/D≤1 | Moderate irritation |
The test results are shown in Table 2:
TABLE 2
As can be seen from the data in table 2: the pet bath cream disclosed by the invention is very mild, and has no irritation to the skin, hair and eyes of a pet.
Test example 2
The pet body wash products provided in examples 1-6 and comparative examples 1-10 were evaluated for their bacteriostatic effect as follows:
With reference to the antibacterial effect test method (suspension quantification method) of the antibacterial daily chemical product in QB/T2738-2012, 10g of the products prepared in examples 1-6 and comparative examples 1-10 were completely dissolved in 300mL of distilled water and the microbial interaction time was 15min. The results of the bacteriostasis rate are shown in table 3:
TABLE 3 Table 3
From the data results in table 3, it can be seen that: the pet bath foam has remarkable antibacterial effect, and five plant extracts of the ramulus et folium Actinidiae Polygamae extract, the catnip extract, the herba Verbenae extract, the calendula extract and the lemon grass extract in the formula have a certain synergistic effect on the exertion of the antibacterial effect. And the addition of thyme oil and rosemary oil further promotes the antibacterial efficacy thereof.
Test example 3
Test of stress resistance:
test sample: examples 1, 3-6 and comparative examples 1-10;
the test method comprises the following steps: the weaned cats 80 with the same variety and 2-5 months of age are selected to be fed in the same environment, and the difference is that different groups of bath cream products are used, and each group is 5. Pouring the pet bath cream for each group of experiments into a small cup before bathing, placing in a bathroom for 10min (a blank group uses conventional bath cream), placing a cat in the bathroom and closing the door, allowing the cat to freely move for 10min, observing the behavior and emotion change of the cat, and after 10min, taking a touch and observing the reaction of the cat to start bathing; the hair of the cat is soaked slowly with warm water, the amount of the bath cream required by each cat is calculated according to the dosage of 1.5mL/Kg of body weight, the bath cream is coated on the whole body of the cat (avoiding eyes, nose and mouth), the bath cream is washed and massaged, the bath cream is ensured to be contacted with skin and hair for 10min, then the cat is washed clean with water, the cat can be prevented from licking himself or herself or foam when bathing by wearing the collar, and the cat is used for 1 time per week. After 4 weeks, cats were bathed according to the same method as described above, and each group of cats was observed for the following stress behavior before and during bathing: (1) whole body curling or standing, (2) trembling, (3) shortness of breath, (4) pupil enlargement, (5) running water or always swallowing water, (6) cat calling, (7) hiding in corners, and (8) ear flattening. The score of 0 for no stress behavior, 1 score for 1 behavior, 2 scores for 2 behaviors, and so on, calculate the total score and count the average for each group.
The test results are shown in table 4:
TABLE 4 Table 4
As can be seen from the data in table 4, the pet shower gel of the present invention has a significant effect of reducing cat stress, wherein the five plant extracts of the knotweed extract, the catnip extract, the verbena extract, the calendula extract and the lemon grass extract have a certain synergistic effect in reducing the exertion of the cat stress effect. And the addition of thyme oil, rosemary oil and gamma-aminobutyric acid further promotes the anti-stress effect.
The applicant states that the pet bath lotion for reducing cat stress and the preparation method thereof are described by the above examples, but the invention is not limited to the above examples, i.e. the invention must not depend on the above examples to be carried out. It should be apparent to those skilled in the art that any modification of the present invention, equivalent substitution of raw materials for the product of the present invention, addition of auxiliary components, selection of specific modes, etc., falls within the scope of the present invention and the scope of disclosure.
The preferred embodiments of the present invention have been described in detail above, but the present invention is not limited to the specific details of the above embodiments, and various simple modifications can be made to the technical solution of the present invention within the scope of the technical concept of the present invention, and all the simple modifications belong to the protection scope of the present invention.
In addition, the specific features described in the above embodiments may be combined in any suitable manner, and in order to avoid unnecessary repetition, various possible combinations are not described further.
Claims (12)
1. The pet bath lotion for reducing the stress response of the cats is characterized by comprising a conditioner, a humectant, an emulsifier, a thickener, a pH regulator and water;
the conditioner is a combination of an extract of polygonum multiflorum, an extract of catnip, an extract of verbena, an extract of calendula, an extract of lemon grass, thyme oil, rosemary oil and gamma-aminobutyric acid;
The pet bath foam for reducing cat stress reaction comprises, by weight, 5-30 parts of a conditioning agent, 0.1-10 parts of a humectant, 25-60 parts of an emulsifying agent, 5-30 parts of a thickening agent, 0.01-0.2 part of a pH regulator and water;
the conditioner comprises, by weight, 1-10 parts of a polygonum multiflorum extract, 1-10 parts of a catnip extract, 1-10 parts of a verbena extract, 1-10 parts of a calendula extract, 1-10 parts of a lemon grass extract, 0.1-1 part of thyme oil, 0.1-1 part of rosemary oil and 0.01-1 part of gamma-aminobutyric acid.
2. The pet body wash for reducing stress in cats according to claim 1, wherein the humectant comprises any one or a combination of at least two of phytosterols, hydrolyzed wheat protein, hydrolyzed silk protein.
3. The pet body wash for reducing cat stress according to claim 1, wherein the emulsifier comprises any one or a combination of at least two of sodium cocoamidopropionate, cocamidopropyl betaine, cocamidomethyl MEA, sodium cocoisethionate, and vegetable alkyl glycosides.
4. The pet body wash for reducing cat stress according to claim 1, wherein the thickener comprises any one or a combination of at least two of lauramidopropyl hydroxysulfobetaine, cationic guar, sodium chloride, 16-18 alcohol, lauryl alcohol, myristyl alcohol, linoleic acid, linolenic acid.
5. The pet body wash for reducing stress in cats according to claim 1, wherein the pH adjusting agent comprises citric acid and/or sodium citrate.
6. The cat stress reducing pet body wash of claim 1, further comprising any one or a combination of a chelating agent and a preservative.
7. The cat stress reducing pet body wash of claim 6, further comprising any one or a combination of 0.01-0.5 parts by weight of a chelating agent and 0.1-1 parts by weight of a preservative.
8. The method of preparing a pet body wash for reducing stress in cats according to any one of claims 1 to 7, wherein the method of preparing comprises:
(1) Mixing an emulsifying agent with water to obtain a first mixed solution;
(2) And mixing the first mixed solution with a conditioner, a thickener, a humectant and a pH regulator.
9. The method of preparing a pet body wash for reducing stress in cats according to claim 8, wherein the water of step (1) is mixed with a chelating agent prior to mixing with an emulsifying agent.
10. The method of claim 8, wherein the step (2) of mixing is further performed with a preservative.
11. The method for preparing a pet body wash for reducing stress in cats according to claim 8, wherein the temperature of mixing in the step (1) is 80-85 ℃ and the mixing time is 5-20 min.
12. The method for preparing a pet body wash for reducing stress in cats according to claim 8, wherein the mixing temperature in the step (2) is 40-60 ℃ and the mixing time is 5-20 min.
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WO2008157847A1 (en) * | 2007-06-20 | 2008-12-24 | The Trustees Of Columbia University In The City Of New York | Skin and surface disinfectant compositions containing botanicals |
CN113499294A (en) * | 2021-08-03 | 2021-10-15 | 媞颂日化用品(广州)有限公司 | Plant composition for cats with skin and hair care effect and application thereof |
CN114452238A (en) * | 2022-01-07 | 2022-05-10 | 佛山市南海东方澳龙制药有限公司 | Medicated bath shampoo for pets with soothing effect and preparation method thereof |
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WO2008042557A2 (en) * | 2006-09-08 | 2008-04-10 | Epidermapet, Llc | Formulation and method for a shampoo for animals |
KR101758327B1 (en) * | 2015-03-31 | 2017-07-26 | 대구한의대학교산학협력단 | A cleansing Composition comprising a extract of Acorus calamus L, and the aromatic oil of Schizonepeta tenuifolia var. japonica and Chrysanthemum indicum L. as an active ingredient with moisturizing effect |
CN107137530A (en) * | 2017-07-12 | 2017-09-08 | 天津市聚星康华医药科技有限公司 | One kind is used for pet composition antianxity |
CN112826790B (en) * | 2021-03-10 | 2022-11-11 | 媞颂日化用品(广州)有限公司 | Pet shower gel capable of improving skin micro-ecology and preparation method thereof |
CN114432170A (en) * | 2022-01-21 | 2022-05-06 | 媞颂日化用品(广州)有限公司 | Mild shower gel for pets and preparation process thereof |
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WO2008157847A1 (en) * | 2007-06-20 | 2008-12-24 | The Trustees Of Columbia University In The City Of New York | Skin and surface disinfectant compositions containing botanicals |
CN113499294A (en) * | 2021-08-03 | 2021-10-15 | 媞颂日化用品(广州)有限公司 | Plant composition for cats with skin and hair care effect and application thereof |
CN114452238A (en) * | 2022-01-07 | 2022-05-10 | 佛山市南海东方澳龙制药有限公司 | Medicated bath shampoo for pets with soothing effect and preparation method thereof |
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