CN115844755A - Tear stain removing gel for pets and preparation method and application thereof - Google Patents
Tear stain removing gel for pets and preparation method and application thereof Download PDFInfo
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- CN115844755A CN115844755A CN202211684269.7A CN202211684269A CN115844755A CN 115844755 A CN115844755 A CN 115844755A CN 202211684269 A CN202211684269 A CN 202211684269A CN 115844755 A CN115844755 A CN 115844755A
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Landscapes
- Cosmetics (AREA)
Abstract
The invention relates to a tear stain removing gel for pets and a preparation method and application thereof. The tear mark removing gel is an external product convenient for pets to use, has glittering and translucent appearance, better viscosity and good smearing sense. The eye drop remover creatively combines the functional components of protease, polyalcohol, emulsifier, grease, bacteriostatic agent and fire-reducing agent, has excellent effect of removing the pet tear stains instantly and for a long time, is mild and non-irritant, and is suitable for sensitive parts of the eyes of pets.
Description
Technical Field
The invention belongs to the technical field of daily chemicals for pets, and relates to a tear stain removing gel for pets, and a preparation method and application thereof.
Background
Although the eye structure of dogs and cats is similar to that of human eyes and is composed of cornea, iris, crystalline lens, retina and the like, cats also have a third eyelid structure which is not possessed by human eyes and have the functions of secreting tears and protecting eyeballs. The lacrimal gland is an accessory organ of eyes and mainly has the functions of secreting tears to moisten eyeballs, and the tears secreted by the lacrimal glands of dogs and cats normally moisten the eyeballs and then enter a nasal cavity through a nasolacrimal duct so as not to flow out of canthus. If the tear water of dogs and cats can not be normally discharged from nasolacrimal ducts, because the tear water contains porphyrin pigment, if the pigment is accumulated below canthus, dark brown stain can be formed, namely tear stains seen by pet owners at ordinary times; besides water, the tears also contain some components such as protein, inorganic salt, lysozyme, oleamide and the like, wherein the lactoferrin component is easily oxidized to form reddish brown, so that the appearance of the pet is affected by the rusty color.
The factors causing the formation of the tear stains of the pets are many, if the pets are careless to eat at ordinary times, people often eat meals, excessive salt is ingested or the diet is too greasy, the salt in the pets is too high, the lacrimal gland of the pets can be exuberantly secreted, and meanwhile, harmful bacteria in the intestinal tract can be abnormally fermented, so that the pets have the tear stains. If the lacrimal gland of the pet develops and discharges too many tears in a short time or the nasolacrimal duct is blocked, the tears cannot be discharged from the lacrimal duct, the tears only flow out of the canthus, and tears are formed in places where the tears flow over time. In addition, the pets are infected with eye inflammation or fire, and the inflammation around the eyes, the secretion of the eyes and the tear stains are also serious.
When a pet develops tear stains, the owner generally cleans the pet by using eye drops or cleaning agents special for the pet. However, the special cleaning agent for tear stains disclosed in the prior art is less, and the common cleaning agent is weak in tear stain removing capability and strong in irritation, is not suitable for sensitive parts of eyes, or can only temporarily clean off the tear stains, and cannot radically reduce the generation of the tear stains of pets, so that the development of a product which is used for pets, has an obvious instant effect of removing the tear stains, can radically reduce the generation of the tear stains of pets, is mild, has no irritation and is high in safety is significant.
Disclosure of Invention
Aiming at the defects of the prior art, the invention aims to provide a tear stain removing gel for pets, and a preparation method and application thereof.
In order to achieve the purpose, the invention adopts the following technical scheme:
in a first aspect, the invention provides a tear stain removing gel for pets, which is prepared from raw materials including protease, polyol, emulsifier, grease, oily thickener, bacteriostatic agent, fire-reducing agent and water.
The tear stain removing gel is an external product convenient for pets to use, is glittering and translucent in appearance, has good viscosity and is good in smearing sense. The composition creatively combines the functional components of protease, polyalcohol, emulsifier, grease, bacteriostatic agent and fire-reducing agent, and has excellent effect of removing the tear stains of pets instantly and for a long time. The protease has strong hydrolysis capability on animal and plant proteins, polypeptides, esters, amides and the like, and mainly plays a role in cleaning tear stains; wherein the polyalcohol has good stabilizing effect on protease; wherein the emulsifier is matched with the protease to play a role in cleaning tear stains; the oil is the main component of the product system, not only can be used as a solvent to enable other oil-soluble components to exist in the system more stably, but also has a certain nursing effect on skin around the eyes of the pet, is mild and non-irritant in components, and is particularly suitable for sensitive parts such as eyes; wherein the bacteriostatic agent prevents the proliferation of microorganisms in tear fluid emanating from the canthus; the internal heat-reducing agent can permeate into skin around eyes to reach the microenvironment of the eyes during the use of the product, has the function of dredging the nasolacrimal duct of the pet, and fundamentally relieves the formation of tear stains.
Preferably, the preparation raw materials of the tear stain removing gel for pets comprise, by mass, 0.01-0.2 part of protease, 0.1-1 part of polyol, 1-20 parts of emulsifier, 50-90 parts of grease, 2-8 parts of oily thickener, 0.01-0.5 part of bacteriostatic agent, 0.01-0.5 part of fire-reducing agent and 0.1-1 part of water.
When the preparation raw materials are combined according to the specific mass ratio, the product system is more stable, and the instant and long-term pet tear stain removing effect is more remarkable.
The protease can be selected from 0.01 part, 0.03 part, 0.05 part, 0.08 part, 0.1 part, 0.12 part, 0.15 part, 0.17 part, 0.2 part and the like in parts by mass.
The polyol can be selected from 0.1 part, 0.2 part, 0.3 part, 0.4 part, 0.5 part, 0.6 part, 0.7 part, 0.8 part, 0.9 part, 1 part and the like in parts by mass.
The emulsifier can be selected from 1 part, 2 parts, 5 parts, 7 parts, 10 parts, 12 parts, 14 parts, 16 parts, 18 parts, 20 parts and the like in parts by mass.
The mass parts of the grease can be selected from 50 parts, 55 parts, 60 parts, 65 parts, 70 parts, 75 parts, 80 parts, 85 parts, 90 parts and the like.
The oily thickener can be selected from 2 parts, 3 parts, 4 parts, 5 parts, 6 parts, 7 parts, 8 parts and the like in parts by weight.
The bacteriostatic agent can be selected from 0.01 part, 0.05 part, 0.1 part, 0.15 part, 0.2 part, 0.25 part, 0.3 part, 0.35 part, 0.4 part, 0.45 part and the like in parts by mass.
The fire-reducing agent can be selected from 0.01 part, 0.05 part, 0.1 part, 0.15 part, 0.2 part, 0.25 part, 0.3 part, 0.35 part, 0.4 part, 0.45 part and the like in parts by mass.
The water can be selected from 0.1 part, 0.2 part, 0.3 part, 0.4 part, 0.5 part, 0.6 part, 0.7 part, 0.8 part, 0.9 part, 1 part and the like in parts by mass.
Other specific point values within the above numerical ranges can be selected, and are not described in detail herein.
Preferably, the protease comprises papain.
The papain is protease capable of decomposing protein in acidic, neutral and alkaline environments, is white to light yellow powder in appearance, and has slight hygroscopicity; the papain is a sulfhydryl-containing endopeptidase, has the activities of protease and esterase, has wider specificity, and has stronger hydrolytic capability on animal and plant proteins, polypeptides, esters, amides and the like. In the present invention, papain is preferred as a protease component, and it has more excellent tear stain removing ability when used in combination with other components.
Preferably, the polyol comprises any one of glycerol, propylene glycol, ethylene glycol, 1-3 butylene glycol or sorbitol, or a combination of at least two thereof. More preferably a combination of glycerol, propylene glycol and sorbitol.
The invention preferably selects the combination of glycerol, propylene glycol and sorbitol as the polyol component of the product, and the combination mode has more obvious stabilizing effect on protease, thereby ensuring the effective exertion of the effect of removing tear stains.
Preferably, the emulsifier comprises glycerol triisostearate and/or sorbitan polyether-30 tetraoleate. A combination of glycerol triisostearate and sorbitan polyether-30 tetraoleate is preferred.
The invention also creatively discovers that the combination mode of the glycerol triisostearate and the sorbitol polyether-30 tetraoleate has more excellent emulsification effect and tear stain removing and cleaning effect.
Preferably, the oil comprises any one or a combination of at least two of squalane, hydrogenated polyparacene, caprylic/capric triglyceride, isononyl isononanoate or isopropyl palmitate.
Preferably, the bacteriostatic agent comprises any one or combination of at least two of verbena oil, honeysuckle oil, rosemary oil or citronella oil. The combination of verbena oil and honeysuckle oil is preferred.
The combination of the verbena oil and the honeysuckle oil is preferably selected as the bacteriostatic agent component of the product, and the combination mode has more remarkable antibacterial and anti-inflammatory effects, and also has the effects of relieving, resisting sensitivity and avoiding stimulation. Honeysuckle flower, honeysuckle flower extract, honeysuckle flower oil and verbena oil have pheromone-like effects on cats, so that most cats can be excited, pleasant mood is generated, fur of cats and dogs can be well nursed, and the effect of repelling mosquitoes can be achieved.
Preferably, the internal heat-reducing agent comprises any one of dandelion extract, mulberry leaf extract or honeysuckle extract or the combination of at least two of the dandelion extract, the mulberry leaf extract and the honeysuckle extract. Preferably a combination of dandelion extract, mulberry leaf extract and honeysuckle extract.
The invention also creatively discovers that the dandelion extract, the mulberry leaf extract and the honeysuckle extract have potential interaction, and have unexpected synergistic effect on improving the tear stain removing long-acting performance of the product.
Preferably, the raw materials for preparing the tear stain removing gel for pets further comprise any one or a combination of at least two of an antioxidant, a preservative, a skin conditioner, a pH conditioner and a fragrance.
Preferably, the antioxidant comprises an oil-soluble fullerene and vitamin E acetate.
The invention also creatively discovers that the antioxidant taking the oil-soluble fullerene and the vitamin E acetate as the combination can synergistically delay the oxidative discoloration of the generated tear stains and reduce the pet aesthetic property influenced by the tear stains to a greater extent.
Preferably, the skin conditioner comprises any one of jojoba oil, sea buckthorn fruit oil, sweet almond oil, camellia oil, olive fruit oil, sweet almond oil, ma Lu lard oil, or meadowfoam seed oil, or a combination of at least two thereof.
In a second aspect, the present invention provides a method for preparing a tear stain removing gel for pets according to the first aspect, the method comprising:
(1) Uniformly stirring the grease and the oily thickener to form transparent gel;
(2) Uniformly stirring the transparent gel obtained in the step (1), protease, polyalcohol and water;
(3) And (3) uniformly stirring the product obtained in the step (2) and the rest raw materials to obtain the product.
The preparation process of the tear stain removing gel for the pets, disclosed by the invention, is simple and easy to operate, and is very suitable for industrial large-scale production.
Preferably, the stirring in step (1) is performed at 100-130 deg.C, such as 100 deg.C, 105 deg.C, 110 deg.C, 115 deg.C, 120 deg.C, 125 deg.C, 130 deg.C, etc.
Preferably, the stirring in step (2) is performed at 15-40 deg.C, such as 15 deg.C, 20 deg.C, 25 deg.C, 30 deg.C, 35 deg.C, 40 deg.C, etc.
Preferably, the stirring in step (3) is performed at 15-40 deg.C, such as 15 deg.C, 20 deg.C, 25 deg.C, 30 deg.C, 35 deg.C, 40 deg.C, etc.
Other specific values within the above ranges can be selected, and are not described in detail herein.
In a third aspect, the invention provides the use of the tear stain removing gel for pets according to the first aspect in preparing a tear stain removing product for pets.
Compared with the prior art, the invention has the following beneficial effects:
the tear mark removing gel is an external product convenient for pets to use, has glittering and translucent appearance, better viscosity and good smearing sense. The pet tear stain remover creatively combines protease, polyalcohol, emulsifier, grease, bacteriostatic agent and fire-clearing agent, and has excellent effect of removing pet tear stains instantly and for a long time. Wherein, the protease has stronger hydrolytic capability to animal and plant proteins, polypeptides, esters, amides and the like, and mainly plays a role in cleaning tear stains; wherein the polyalcohol has good stabilizing effect on protease; wherein the emulsifier is matched with the protease to play a role in cleaning tear stains; the oil is the main component of the product system, not only can be used as a solvent to enable other oil-soluble components to exist in the system more stably, but also has a certain nursing effect on skin around the eyes of the pet, is mild and non-irritant in components, and is particularly suitable for sensitive parts such as eyes; wherein the bacteriostatic agent prevents the proliferation of microorganisms in tear fluid emanating from the canthus; the internal heat-reducing agent can permeate into skin around eyes to reach the microenvironment of the eyes during the use of the product, has the function of dredging the nasolacrimal duct of the pet, and fundamentally relieves the formation of tear stains.
Furthermore, the honeysuckle oil and the verbena oil added into the bacteriostatic agent have the similar pheromone effect on the cats, so that most cats can be excited, pleasant mood can be generated, fur of the cats and dogs can be well nursed, and the effect of repelling mosquitoes can be achieved.
Detailed Description
To further illustrate the technical means and effects of the present invention, the following further describes the technical solution of the present invention with reference to the preferred embodiments of the present invention, but the present invention is not limited to the scope of the embodiments.
The following examples relate to some of the raw material sources as follows:
| raw materials | Purchase source | Model number |
| Oily thickener | American Keteng | G1701 |
| Papain | Virgipeptide (Guangdong) Biotech Co., ltd | Papain 99% |
| Glycerol triisostearate | Basf-Fr | Cithrol 10GTIS-LQ-(MV) |
| Sorbitol polyether-30 tetraoleate | Japanese king of flowers | Rhcodol 430V |
| HydrogenationPolymaltene | Snow dragon of America | PAO-4 |
| Oil-soluble fullerene | Mitsubishi of Japan | Fullerene qu |
| European Verbena oil | Jian City Rongsheng plant Co., ltd | / |
| Honeysuckle flower oil | Jiangxi cedar natural medicinal oil Co.,Ltd. | / |
| Dandelion extract | Xian Youshou Biotech Co., ltd | Food grade, 99% |
| Folium Mori extract | Xiansushou Biotech Ltd | Food grade, 99% |
| Honeysuckle extract | Xiansushou Biotech Ltd | Food grade, 99% |
| Jojoba oil | Jiangxi cedar natural medicinal oil Co.,Ltd. | / |
| Sea buckthorn fruitOil | Jiangxi cedar natural medicinal oil Co.,Ltd. | / |
| Rosemary oil | Jiangxi cedar natural medicinal oil Co.,Ltd. | / |
| Citronella oil | Jiangxi cedar natural medicinal oil Co.,Ltd. | / |
Other materials were purchased from commercial sources.
Example 1
The present embodiment provides a tear stain removing gel for pets, which has the following formula table:
the preparation method comprises the following steps:
(1) Uniformly stirring the grease and the oily thickener at 120 ℃ to form transparent gel;
(2) Uniformly stirring the transparent gel, protease, polyalcohol and water at 40 ℃;
(3) And (3) uniformly stirring the product obtained in the step (2) and the rest raw materials at the temperature of 30 ℃ to obtain the product.
Example 2
The present embodiment provides a tear stain removing gel for pets, which has the following formula table:
the preparation method comprises the following steps:
(1) Stirring oil and oily thickener at 110 deg.C to form transparent gel;
(2) Uniformly stirring the transparent gel, protease, polyalcohol and water at 35 ℃;
(3) And (3) uniformly stirring the product obtained in the step (2) and the rest raw materials at 25 ℃ to obtain the product.
Example 3
The present embodiment provides a tear stain removing gel for pets, which has the following formula table:
the preparation method comprises the following steps:
(1) Uniformly stirring the grease and the oily thickener at 125 ℃ to form transparent gel;
(2) Uniformly stirring the transparent gel, protease, polyalcohol and water at 40 ℃;
(3) And (3) uniformly stirring the product obtained in the step (2) and the rest raw materials at 40 ℃ to obtain the product.
Example 4
This example provides a tear stain removing gel for pets, which is different from that of example 1 only in that the formulations of the polyols are 0.25% of propylene glycol and 0.25% of sorbitol, and other components and contents are kept unchanged. The preparation method is as in example 1.
Example 5
The present example provides a tear stain removing gel for pets, which is different from that in example 1 only in the formulation of polyol, including 0.375% of glycerin and 0.125% of sorbitol, and the other components and contents thereof are kept unchanged. The preparation method is as in example 1.
Example 6
This example provides a tear stain removing gel for pets, which is prepared according to a formulation different from that of example 1, wherein the formulation of the polyol is 0.375% of glycerin and 0.125% of propylene glycol, and the other components and contents are kept unchanged. The preparation method is referred to example 1.
Example 7
This example provides a tear stain removing gel for pets, which is different from the formulation of example 1 only in that the formulation of the emulsifier is 18% of glycerol triisostearate alone, and other components and contents are kept unchanged. The preparation method is as in example 1.
Example 8
This example provides a tear stain removing gel for pets, which is different from the formulation of example 1 only in that the formulation of the emulsifier is 18% of single sorbitan polyether-30 tetraoleate, and other components and contents are kept unchanged. The preparation method is as in example 1.
Example 9
The present example provides a tear stain removing gel for pets, which is different from the formulation of example 1 only in that the formulation of the bacteriostatic agent is different, and the formulation is 0.2% of the single verbena oil, and the other components and contents are all kept unchanged. The preparation method is as in example 1.
Example 10
The present embodiment provides a tear stain removing gel for pets, which is different from that in embodiment 1 only in that the formulation of the bacteriostatic agent is different, and the formulation is 0.2% of a single honeysuckle flower oil, and other components and contents of the honeysuckle flower oil are all kept unchanged. The preparation method is as in example 1.
Example 11
The embodiment provides a tear stain removing gel for pets, which is different from the formulation of the fire-reducing agent in embodiment 1 only in that the formulation of the fire-reducing agent is 0.25 percent of mulberry leaf extract and 0.25 percent of honeysuckle flower extract, and other components and contents are kept unchanged. The preparation method is as in example 1.
Example 12
The present example provides a tear stain removing gel for pets, which is different from the formulation of example 1 only in that the formulation of the fire-reducing agent is 0.16% of dandelion extract and 0.34% of honeysuckle extract, and other components and contents are all kept unchanged. The preparation method is as in example 1.
Example 13
The present example provides a tear stain removing gel for pets, which is different from the formulation of example 1 only in that the formulation of the fire-reducing agent is 0.16% of dandelion extract and 0.34% of mulberry leaf extract, and other components and contents are kept unchanged. The preparation method is as in example 1.
Example 14
This example provides a tear stain removing gel for pets, which is different from the formulation of example 1 only in that the formulation of the antioxidant is 0.06% of a single oil-soluble fullerene, and other components and contents are kept unchanged. The preparation method is as in example 1.
Example 15
This example provides a tear stain removing gel for pets, which is different from the formulation of example 1 only in that the antioxidant formulation is 0.06% of vitamin E acetate alone, and the other components and contents thereof are kept unchanged. The preparation method is as in example 1.
Comparative example 1
This comparative example provides a tear stain removing gel for pets whose formulation differs from example 1 only in that it does not contain a protease component and in that it is supplemented with hydrogenated polyprenyl. The other components and contents are kept unchanged. The preparation method is as in example 1.
Comparative example 2
This comparative example provides a tear stain removing gel for pets, which formulation differs from example 1 only in that no polyol component is present and the content thereof is complemented by hydrogenated polyprenol. The other components and contents are kept unchanged. The preparation method is as in example 1.
Comparative example 3
This comparative example provides a tear stain removing gel for pets whose formulation differs from example 1 only in that it does not contain an ingredient of an internal heat-reducing agent, the content of which is complemented by hydrogenated polyprenyl. The other components and contents are kept unchanged. The preparation method is as in example 1.
Test example 1
The gel products obtained in examples 1 to 15 were subjected to safety evaluation:
(1) Erythrocyte hemolysis assay
Preparation of erythrocyte suspension: selecting healthy rabbit, taking 9mL of blood from heart, adding 1mL of 2% potassium oxalate solution, centrifuging, discarding supernatant, diluting the precipitate to 20mL with 20mmol/L PBS solution, and storing at 4 ℃ for later use. Each set of samples was selected to be diluted to different concentrations with PBS solution, with 5 concentration gradients set for each sample. Taking 10mL of a diluent of a sample to be tested, adding 200 μ L of the erythrocyte suspension (controlling the final concentration of the sample to be 5, 10, 20, 50 and 100mg/mL respectively), taking distilled water as a total blood-dissolving control, taking a PBS solution as a negative control, gently mixing, incubating for 30min at 37 ℃, centrifuging for 10min at the rotating speed of 2000r/min, taking a supernatant, testing the absorbance (A560) of the supernatant at 560nm by using a spectrophotometer, and calculating the hemolysis rate according to the following formula;
hemolysis rate = [ (experimental group) A560 Negative control group A560 ) /(Whole blood control group) A560 Negative control group A560 )]×100％
A standard curve of the hemolysis rate versus the concentration of the sample was plotted, and the concentration of the sample at which 50% of erythrocytes were hemolyzed (HD 50) was calculated.
(2) Protein denaturation assay
Diluting each group of samples to 10g/L by PBS (phosphate buffer solution), taking 10mL of diluent of a sample to be detected, adding 200 mu L of the erythrocyte suspension, taking distilled water as a blank control and 1mg/mL of Sodium Dodecyl Sulfate (SDS) solution as a positive control, gently mixing, incubating at 37 ℃ for 30min, centrifuging at the rotating speed of 2000r/min for 10min, taking supernate, respectively testing the absorbances A540 and A575 at 540nm and 575nm by a spectrophotometer, and calculating the protein Denaturation Index (DI) according to the following formula;
DI＝[(R 1 -R 2 )/(R 1 -R 3 )]×100％
wherein R is 1 = blank control group a 575 Blank control group A 540 ，R 2 = Experimental group A 575 Experimental group A 540 ，R 3 = positive control group a 575 Positive control group A 540 。
And evaluating the irritation of the sample to be tested according to the L/D value, wherein the L/D value is HD50/DI, and the irritation grading standard is shown in the following table:
| L/D | grading |
| ＞100 | Has no irritation |
| 10＜L/D≤100 | Micro-stimulation property |
| 1＜L/D≤10 | Mild irritation |
| 0.1＜L/D≤1 | Moderate irritation |
The test results show that the products of examples 1-15 are non-irritant, which indicates that the tear stain removing gel for pets is mild, non-irritant and high in safety.
Test example 2
The test example evaluates the tear stain removing effect of the tear stain removing gel for pets on pet cats:
the British shorthair cats with 32 tear stains and the Garfield cats with 32 tear stains are selected as study objects and divided into 16 groups, wherein each group comprises 2 British shorthair cats and 2 Garfield cats, and the age distribution and the tear stains of the cats in the same type are basically consistent. The tear stain removal gel products for pets of examples 1-13 and comparative examples 1-3 were used per group, respectively, by the following methods: preliminarily cleaning hair around eyes, smearing a proper amount of gel product on the cat eyes without mistakenly smearing the gel product on the cat eyes, massaging for 5min, finally cleaning the eyes, using the gel product for 1 time every day, observing the instant tear-stain removing effect of each time, and scoring the effect by a pet owner. The scoring criteria are shown in the following table, and the average values of the scores are shown in table 1.
The length (mm) of tear stains of all cats was measured with a straight ruler after each week and before tear stain removal treatment, and tear stain removal treatment was performed for 6 weeks to evaluate the long-term effect of tear stain removal. The test results are shown in table 1, which shows the degree of reduction of tear length, which is [ (length of tear at week n-length of tear before test)/length of tear before test ] × 100%.
TABLE 1
From the data in table 1: the tear stain removing gel for the pet has obvious instant and long-term removing effects on tear stains generated by the cat, wherein the fire removing agent and the formula composition of the fire removing agent mainly influence the long-term tear stain removing effect of the product, and the protease, the polyalcohol and the formula of the polyalcohol, the emulsifier and the formula of the emulsifier mainly influence the instant tear stain removing effect of the product.
Test example 3
The test example evaluates the tear stain removing effect of the tear stain removing gel for pets on pet dogs:
54 poodle dogs with the tear stain phenomenon of Xiong Quan and 54 poodle dogs with the tear stain phenomenon are selected as research objects and divided into 18 groups, each group comprises 3 poodle dogs with the tear stain phenomenon of Xiong Quan and 3 poodle dogs, and the age distribution and the tear stain degree of each group of dogs of the same type are basically consistent. The tear stain removal gel products for pets of examples 1-15 and comparative examples 1-3 were used per group, respectively, by the following methods: primarily cleaning hair around eyes, applying a proper amount of gel product to the circumference of eyes of a dog without mistakenly applying the gel product to the eyes, massaging for 5min, finally cleaning the circumference of eyes, using the gel product for 1 time every day, observing the instant tear-stain removing effect of each time, and scoring the effect by a pet owner. The scoring criteria are shown in the following table, and the average scores are shown in table 2.
| Scoring | Immediate tear stain removing effect |
| 1 | Slight lightening of tear color after periocular application and cleansing |
| 2 | The color of the tear mark becomes obviously lighter after the eye is used and cleaned, and a light mark is left |
| 3 | The tear stains after using and cleaning the eye are basically and completely removed |
After 5 weeks of product use, the product was discontinued and all canine tears were measured in length (mm) with a ruler. The test results are shown in table 2, which shows the degree of reduction of tear mark length, which is [ (length of tear mark at week 5-length of tear mark before test)/length of tear mark before test ] × 100%. And observing the color depth of the tear stains of each group of pet dogs after the tear stains stay on the cheeks of the pet dogs for one week, evaluating the anti-tear oxidative discoloration effect of the tear stain removing gel, and scoring the effect by a pet owner. The scoring criteria are shown in the table below, and the scores are shown in table 2.
| Grade | Anti-tear oxidation discoloration effect |
| * | Compared with the group of example 1, the color of the tear stains is obviously darker than that of the tear stains of Xiong Quan and the poodle dog |
| ** | The tear stains were significantly darker in color than those of the bear or poodle dogs as compared with the group of example 1 |
| *** | Compared with the group of example 1, the color depth of the tear stains is not obviously different from that of the tear stains of Xiong Quan and the poodle dog |
TABLE 2
As can be seen from the data in Table 2: the tear stain removing gel for the pet has obvious instant and long-term removing effects on tear stains generated by dogs, wherein the fire removing agent and the formula of the fire removing agent mainly influence the long-term tear stain removing effect of a product, and the protease, the polyalcohol and the formula of the polyalcohol, the emulsifier and the formula of the emulsifier mainly influence the instant tear stain removing effect of the product. And the formula of the antioxidant mainly influences the anti-tear-stain oxidative discoloration effect of the product.
The applicant states that the tear stain removing gel for pets, the preparation method and the application thereof are described by the embodiments, but the invention is not limited to the embodiments, that is, the invention can be implemented only by relying on the embodiments. It should be understood by those skilled in the art that any modification of the present invention, equivalent substitutions of the raw materials of the product of the present invention, addition of auxiliary components, selection of specific modes, etc., are within the scope and disclosure of the present invention.
The preferred embodiments of the present invention have been described in detail, however, the present invention is not limited to the specific details of the above embodiments, and various simple modifications may be made to the technical solution of the present invention within the technical idea of the present invention, and these simple modifications are within the protective scope of the present invention.
It should be noted that the various technical features described in the above embodiments can be combined in any suitable manner without contradiction, and the invention is not described in any way for the possible combinations in order to avoid unnecessary repetition.
Claims (10)
1. The tear stain removing gel for the pets is characterized by being prepared from raw materials including protease, polyhydric alcohol, emulsifier, grease, oily thickener, bacteriostatic agent, fire-reducing agent and water.
2. The tear stain removing gel for pets according to claim 1, characterized in that the raw materials for preparing the tear stain removing gel for pets comprise, by mass, 0.01-0.2 part of protease, 0.1-1 part of polyol, 1-20 parts of emulsifier, 50-90 parts of grease, 2-8 parts of oily thickener, 0.01-0.5 part of bacteriostatic agent, 0.01-0.5 part of fire-reducing agent and 0.1-1 part of water.
3. The tear stain removal gel for pets according to claim 1 or 2, wherein the protease comprises papain;
preferably, the polyhydric alcohol comprises any one of glycerol, propylene glycol, ethylene glycol, 1-3 butylene glycol or sorbitol, or a combination of at least two thereof; more preferably a combination of glycerol, propylene glycol and sorbitol.
4. The tear stain removing gel for pets according to any of claims 1-3, wherein the emulsifier comprises glycerol triisostearate and/or sorbitan polyether-30 tetraoleate; preferably glycerol triisostearate and sorbitan polyether-30 tetraoleate;
preferably, the oil comprises any one or a combination of at least two of squalane, hydrogenated polyparacene, caprylic/capric triglyceride, isononyl isononanoate or isopropyl palmitate.
5. The tear stain removing gel for pets according to any one of claims 1 to 4, wherein the bacteriostatic agent comprises any one or a combination of at least two of verbena oil, honeysuckle oil, rosemary oil or citronella oil; the combination of verbena oil and honeysuckle oil is preferred.
6. The tear stain removing gel for pets according to any one of claims 1 to 5, wherein the fire-reducing agent comprises any one or a combination of at least two of dandelion extract, mulberry leaf extract or honeysuckle flower extract; preferably a combination of dandelion extract, mulberry leaf extract and honeysuckle extract.
7. The tear stain removal gel for pets according to any one of claims 1 to 6, characterized in that the raw materials for preparing the tear stain removal gel for pets further comprise any one of or a combination of at least two of an antioxidant, a preservative, a skin conditioner, a pH conditioner and a fragrance;
preferably, the antioxidant comprises oil-soluble fullerene and vitamin E acetate;
preferably, the skin conditioning agent comprises any one or a combination of at least two of jojoba oil, sea buckthorn fruit oil, sweet almond oil, camellia oil, olive fruit oil, sweet almond oil, ma Lu lard, or meadowfoam seed oil.
8. The preparation method of the tear stain removal gel for pets according to any one of claims 1-7, wherein the preparation method comprises:
(1) Uniformly stirring the grease and the oily thickener to form transparent gel;
(2) Uniformly stirring the transparent gel obtained in the step (1), protease, polyalcohol and water;
(3) And (3) uniformly stirring the product obtained in the step (2) and the rest raw materials to obtain the product.
9. The method for preparing the tear stain removing gel for the pet according to claim 8, wherein the step (1) of uniformly stirring is performed at 100-130 ℃;
preferably, the stirring in the step (2) is uniformly carried out at 15-40 ℃;
preferably, the stirring in step (3) is carried out at 15-40 ℃.
10. Use of the tear stain removing gel for pets according to any one of claims 1-7 in preparation of tear stain removing products for pets.
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