CN115279482B - 微液滴、气泡生成装置 - Google Patents

微液滴、气泡生成装置 Download PDF

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Publication number
CN115279482B
CN115279482B CN202180020585.1A CN202180020585A CN115279482B CN 115279482 B CN115279482 B CN 115279482B CN 202180020585 A CN202180020585 A CN 202180020585A CN 115279482 B CN115279482 B CN 115279482B
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micro
slit
continuous phase
flow path
phase
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Chinese (zh)
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CN115279482A (zh
Inventor
西迫贵志
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National Research And Development Corp Science And Technology Revitalization Organization
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National Research And Development Corp Science And Technology Revitalization Organization
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    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F33/00—Other mixers; Mixing plants; Combinations of mixers
    • B01F33/30—Micromixers
    • B01F33/301—Micromixers using specific means for arranging the streams to be mixed, e.g. channel geometries or dispositions
    • B01F33/3012—Interdigital streams, e.g. lamellae
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F23/00—Mixing according to the phases to be mixed, e.g. dispersing or emulsifying
    • B01F23/40—Mixing liquids with liquids; Emulsifying
    • B01F23/41—Emulsifying
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F23/00—Mixing according to the phases to be mixed, e.g. dispersing or emulsifying
    • B01F23/20—Mixing gases with liquids
    • B01F23/23—Mixing gases with liquids by introducing gases into liquid media, e.g. for producing aerated liquids
    • B01F23/232—Mixing gases with liquids by introducing gases into liquid media, e.g. for producing aerated liquids using flow-mixing means for introducing the gases, e.g. baffles
    • B01F23/2323—Mixing gases with liquids by introducing gases into liquid media, e.g. for producing aerated liquids using flow-mixing means for introducing the gases, e.g. baffles by circulating the flow in guiding constructions or conduits
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F23/00—Mixing according to the phases to be mixed, e.g. dispersing or emulsifying
    • B01F23/40—Mixing liquids with liquids; Emulsifying
    • B01F23/41—Emulsifying
    • B01F23/414—Emulsifying characterised by the internal structure of the emulsion
    • B01F23/4143—Microemulsions
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F25/00—Flow mixers; Mixers for falling materials, e.g. solid particles
    • B01F25/30—Injector mixers
    • B01F25/31—Injector mixers in conduits or tubes through which the main component flows
    • B01F25/314—Injector mixers in conduits or tubes through which the main component flows wherein additional components are introduced at the circumference of the conduit
    • B01F25/3141—Injector mixers in conduits or tubes through which the main component flows wherein additional components are introduced at the circumference of the conduit with additional mixing means other than injector mixers
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F25/00—Flow mixers; Mixers for falling materials, e.g. solid particles
    • B01F25/30—Injector mixers
    • B01F25/31—Injector mixers in conduits or tubes through which the main component flows
    • B01F25/314—Injector mixers in conduits or tubes through which the main component flows wherein additional components are introduced at the circumference of the conduit
    • B01F25/3143—Injector mixers in conduits or tubes through which the main component flows wherein additional components are introduced at the circumference of the conduit characterised by the specific design of the injector
    • B01F25/31432—Injector mixers in conduits or tubes through which the main component flows wherein additional components are introduced at the circumference of the conduit characterised by the specific design of the injector being a slit extending in the circumferential direction only
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F25/00—Flow mixers; Mixers for falling materials, e.g. solid particles
    • B01F25/40—Static mixers
    • B01F25/42—Static mixers in which the mixing is affected by moving the components jointly in changing directions, e.g. in tubes provided with baffles or obstructions
    • B01F25/43—Mixing tubes, e.g. wherein the material is moved in a radial or partly reversed direction
    • B01F25/433—Mixing tubes wherein the shape of the tube influences the mixing, e.g. mixing tubes with varying cross-section or provided with inwardly extending profiles
    • B01F25/4335—Mixers with a converging-diverging cross-section
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F33/00—Other mixers; Mixing plants; Combinations of mixers
    • B01F33/30—Micromixers
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F33/00—Other mixers; Mixing plants; Combinations of mixers
    • B01F33/30—Micromixers
    • B01F33/301—Micromixers using specific means for arranging the streams to be mixed, e.g. channel geometries or dispositions
    • B01F33/3011—Micromixers using specific means for arranging the streams to be mixed, e.g. channel geometries or dispositions using a sheathing stream of a fluid surrounding a central stream of a different fluid, e.g. for reducing the cross-section of the central stream or to produce droplets from the central stream
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F33/00—Other mixers; Mixing plants; Combinations of mixers
    • B01F33/30—Micromixers
    • B01F33/3035—Micromixers using surface tension to mix, move or hold the fluids
    • B01F33/30351—Micromixers using surface tension to mix, move or hold the fluids using hydrophilic/hydrophobic surfaces
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F33/00—Other mixers; Mixing plants; Combinations of mixers
    • B01F33/80—Mixing plants; Combinations of mixers
    • B01F33/81—Combinations of similar mixers, e.g. with rotary stirring devices in two or more receptacles
    • B01F33/813—Combinations of similar mixers, e.g. with rotary stirring devices in two or more receptacles mixing simultaneously in two or more mixing receptacles
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F35/00—Accessories for mixers; Auxiliary operations or auxiliary devices; Parts or details of general application
    • B01F35/56—General build-up of the mixers
    • B01F35/561—General build-up of the mixers the mixer being built-up from a plurality of modules or stacked plates comprising complete or partial elements of the mixer
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B81—MICROSTRUCTURAL TECHNOLOGY
    • B81B—MICROSTRUCTURAL DEVICES OR SYSTEMS, e.g. MICROMECHANICAL DEVICES
    • B81B1/00—Devices without movable or flexible elements, e.g. microcapillary devices
    • B81B1/006—Microdevices formed as a single homogeneous piece, i.e. wherein the mechanical function is obtained by the use of the device, e.g. cutters
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F2215/00—Auxiliary or complementary information in relation with mixing
    • B01F2215/04—Technical information in relation with mixing
    • B01F2215/0413—Numerical information
    • B01F2215/0418—Geometrical information
    • B01F2215/0431—Numerical size values, e.g. diameter of a hole or conduit, area, volume, length, width, or ratios thereof
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B81—MICROSTRUCTURAL TECHNOLOGY
    • B81B—MICROSTRUCTURAL DEVICES OR SYSTEMS, e.g. MICROMECHANICAL DEVICES
    • B81B2201/00—Specific applications of microelectromechanical systems
    • B81B2201/05—Microfluidics
    • B81B2201/057—Micropipets, dropformers
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B81—MICROSTRUCTURAL TECHNOLOGY
    • B81B—MICROSTRUCTURAL DEVICES OR SYSTEMS, e.g. MICROMECHANICAL DEVICES
    • B81B2203/00—Basic microelectromechanical structures
    • B81B2203/03—Static structures
    • B81B2203/0323—Grooves
    • B81B2203/0338—Channels

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  • Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Computer Hardware Design (AREA)
  • Microelectronics & Electronic Packaging (AREA)
  • Dispersion Chemistry (AREA)
  • Micromachines (AREA)
  • Physical Or Chemical Processes And Apparatus (AREA)
CN202180020585.1A 2020-03-13 2021-03-12 微液滴、气泡生成装置 Active CN115279482B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP2020-044633 2020-03-13
JP2020044633 2020-03-13
PCT/JP2021/010205 WO2021182632A1 (ja) 2020-03-13 2021-03-12 マイクロ液滴・気泡生成デバイス

Publications (2)

Publication Number Publication Date
CN115279482A CN115279482A (zh) 2022-11-01
CN115279482B true CN115279482B (zh) 2024-12-13

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Country Status (5)

Country Link
US (1) US12589372B2 (https=)
EP (1) EP4119221A4 (https=)
JP (1) JP7390078B2 (https=)
CN (1) CN115279482B (https=)
WO (1) WO2021182632A1 (https=)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2024154499A1 (ja) * 2023-01-17 2024-07-25 Ｔｏｐｐａｎホールディングス株式会社 マイクロ流路チップ及びその製造方法
CN120778581A (zh) * 2025-07-21 2025-10-14 广东医科大学 一种可用于操控和传感亚波长微粒的声学微粒传感系统与方法

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN106140340A (zh) * 2016-08-19 2016-11-23 北京工业大学 基于流动聚焦型微通道合成微乳液滴的微流控芯片
WO2019168130A1 (ja) * 2018-02-28 2019-09-06 国立大学法人東京工業大学 マイクロ液滴・気泡生成デバイス

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP4032128B2 (ja) * 2002-08-01 2008-01-16 東ソー株式会社 微小流路構造体、構成されるデスクサイズ型化学プラント及びそれらを用いた微粒子製造装置
EP1391237B1 (en) * 2002-08-01 2011-09-21 Tosoh Corporation Fine channel device, desksize chemical plant and fine particle producing apparatus employing them
AU2004229440B2 (en) * 2003-04-10 2010-08-12 President And Fellows Of Harvard College Formation and control of fluidic species
JP4042683B2 (ja) * 2003-11-17 2008-02-06 東ソー株式会社 微小流路構造体及びこれを用いた微小粒子製造方法
EP1757357B1 (en) * 2004-03-23 2013-04-24 Japan Science and Technology Agency Method and device for producing micro-droplets
NL2002862C2 (en) * 2009-05-08 2010-11-09 Friesland Brands Bv Microfluidic apparatus and method for generating a dispersion.
WO2012008497A1 (ja) * 2010-07-13 2012-01-19 国立大学法人東京工業大学 微小液滴の製造装置
AU2014233699B2 (en) * 2013-03-15 2018-05-24 The Regents Of The University Of California High-speed on demand microfluidic droplet generation and manipulation
US10610865B2 (en) * 2017-08-22 2020-04-07 10X Genomics, Inc. Droplet forming devices and system with differential surface properties
CN207614861U (zh) * 2017-11-06 2018-07-17 北京天健惠康生物科技有限公司 微液滴生成装置
EP3774005B1 (en) * 2018-04-02 2025-01-29 Dropworks, Inc. Systems and methods for serial flow emulsion processes
CN108671970B (zh) * 2018-04-11 2020-07-14 华南师范大学 一种基于微流控芯片的双尺寸微液滴的产生方法

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN106140340A (zh) * 2016-08-19 2016-11-23 北京工业大学 基于流动聚焦型微通道合成微乳液滴的微流控芯片
WO2019168130A1 (ja) * 2018-02-28 2019-09-06 国立大学法人東京工業大学 マイクロ液滴・気泡生成デバイス

Also Published As

Publication number Publication date
EP4119221A4 (en) 2024-04-17
EP4119221A1 (en) 2023-01-18
JPWO2021182632A1 (https=) 2021-09-16
JP7390078B2 (ja) 2023-12-01
US12589372B2 (en) 2026-03-31
WO2021182632A1 (ja) 2021-09-16
CN115279482A (zh) 2022-11-01
US20230142172A1 (en) 2023-05-11

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