CN115252738B - 一种具有抑菌止痒净味作用的组合物及其制备方法和应用 - Google Patents
一种具有抑菌止痒净味作用的组合物及其制备方法和应用 Download PDFInfo
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Abstract
本发明公开了一种具有抑菌止痒净味作用的组合物及其制备方法和应用。所述组合物,包括以下重量份数的各组分:蛇床子提取物6~14份、百部提取物5~13份、青蒿提取物10~16份、牡丹皮提取物5~10份、莪术提取物5~10份、黄芪提取物5~12份、甘草提取物3~8份。本发明的组合物通过将具有选择性抑制有害菌(白色念珠菌、大肠杆菌、金黄色葡萄球菌),而不伤害有益菌(乳酸杆菌)的蛇床子提取物、百部提取物、青蒿提取物、牡丹皮提取物、莪术提取物组合使用,同时搭配不具有抗菌作用的黄芪提取物和甘草提取物,可以产生显著的协同抑有害菌群的作用,而不伤害有益菌,可进一步用于女性私处处理产品生产中。
Description
技术领域
本发明涉及卫生产品技术领域,更具体地,涉及一种具有抑菌止痒净味作用的组合物及其制备方法和应用。
背景技术
众所周知,女性下生殖道为开放性腔道,是人体内重要的微生态区,正常情况下是以优势菌为主组成的微生态系统。而女性阴道微生态失衡是引起妇科外阴及阴道炎症反复发作的主要原因。目前,阴道分泌物中已分离到29种之多的微生物,其中最重要的是乳酸杆菌,它在健康女性的阴道排出物标本中分离率高达50%~80%。它能产生一些抗微生物的物质,包括乳酸、细菌素、乳酸素B和过氧化氢。产过氧化氢的乳酸杆菌在控制阴道微生态环境中起重要作用,并通过与其他过氧化物的联合作用抑制其他病原体过度生长。
正常生育年龄的妇女,体内存在足量的雌激素,和阴道里占主导地位的乳酸杆菌一起,使阴道处于一种酸性的环境(pH值大约3.8~4.5.正常情况下,阴道上皮细胞随月经周期中雌、孕激素的作用,发生周期性变化,特别是表层细胞,细胞内富含糖原,糖原分泌后,经寄生于阴道内的阴道杆菌的作用将其分解为乳酸,使阴道内保持pH为4.5的酸性环境,从而抑制致病菌的繁殖,故正常阴道液有自净或灭菌作用。
随着年龄的推移,女性身体机能或免疫力的下降,很快阴道的“有益菌”就会逐步下降。加之性生活、月经、妊娠、哺乳、妇科手术、不当的洁阴方式及其女性特殊的生理结构、外阴损伤、情绪波动等都会影响到阴道微生态系统的“菌群平衡,使“有害菌”过度繁殖,从而引起各种妇科疾病感染,尤其是妇科疾病发作后传统的治疗方式都是大量使用广谱抗菌药物、抗生素类的中西药或“统杀型”的洁阴产品,从而使阴道的“菌群平衡”严重破坏,阴道失去了和平的保护神,自洁功能大大下降,各种“有害菌”乘虚而入并大量繁殖,在外阴部、阴部内、宫颈口等处疯狂滋事,更进一步导致各种妇科疾病感染和反复发作。
中医药治疗具有完整的理论和方药体系,以及良好的临床效果和较小的副作用,因此也日益受到广泛的关注。因而,开发一种能够选择性抑制有害菌,不伤害有益菌的中药源洁阴产品,是目前亟待解决的问题。
发明内容
本发明的目的在于克服现有技术中存在的上述缺陷和不足,提供一种具有抑菌止痒净味作用的组合物。
本发明的第二个目的在于提供所述具有抑菌止痒净味作用的组合物的制备方法。
本发明的第三个目的在于提供所述具有抑菌止痒净味作用的组合物的应用。
本发明的上述目的是通过以下技术方案给予实现的:
一种具有抑菌止痒净味作用的组合物,包括以下重量份数的各组分:蛇床子提取物6~14份、百部提取物5~13份、青蒿提取物10~16份、牡丹皮提取物5~10份、莪术提取物5~10份、黄芪提取物5~12份、甘草提取物3~8份。上述植物提取物均为50%的生药量的水提物。
本发明研究表明,将蛇床子提取物、百部提取物、青蒿提取物、牡丹皮提取物、莪术提取物以一定配比组合使用时,其对常见的阴道有害菌,如白色念珠菌、大肠杆菌、金黄色葡萄球菌等具有较好的快速抑制效果,作用2min,抑菌效果可达80%以上,而对阴道有益菌,主要是乳酸杆菌也具有一定的抑制作用,作用2min,抑菌率40.0%左右;而在上述配方基础上再复配一定用量不具有抗菌作用的黄芪提取物和甘草提取物之后发现,得到的中药组合物对上述常见的阴道有害菌的抑菌效果又有提升,且对有益菌的抑菌率显著降低,降低到了5.0%以下,具有显著的协同增效作用。所述组合物的组分均为天然植物成分,温和不刺激,可进一步用于女性私处护理产品生产中。
优选地,所述组合物包括以下重量份数的各组分:蛇床子提取物8~12份、百部提取物7~11份、青蒿提取物13~15份、牡丹皮提取物6~9份、莪术提取物6~9份、黄芪提取物6~10份、甘草提取物3~6份。
进一步优选地,所述组合物包括以下重量份数的各组分:蛇床子提取物12份、百部提取物9份、青蒿提取物15份、牡丹皮提取物9份、莪术提取物9份、黄芪提取物10份、甘草提取物6份。
进一步优选地,所述组合物还包括卷柏提取物3~6份。卷柏为卷柏科植物卷柏Selaginella tamariscina(Beauv.)Spring或垫状卷柏Selaginella pulvinata(HooK.etGrev.)Maxim.的干燥全草。具有活血通经,用于经闭痛经,癓瘕痞块,跌扑损伤,吐血,崩漏,便血,脱肛等,在本发明中主要起到皮肤的保湿能力及抗老化功效。
进一步优选地,所述组合物还包括冰片0.005~0.01份。青蒿提取物、莪术提取物和冰片具有抑制Hpv的功效,同时,冰片作为促渗透的功能,能够促进其他功效成分渗透表皮起效。
进一步优选地,所述组合物包括以下重量份数的各组分:蛇床子提取物12份、百部提取物9份、青蒿提取物15份、牡丹皮提取物9份、莪术提取物9份、黄芪提取物10份、甘草提取物6份、卷柏提取物6份。
进一步优选地,所述组合物还包括菊粉1~2份、α-葡聚糖寡糖0.2~0.5份。通过添加一定量的菊粉和α-葡聚糖寡糖可以促进阴道局部有益菌生长。
进一步优选地,所述组合物还包括石榴籽油0.1~0.2份、茉莉花油0.1~0.2份、白兰花精油0.1~0.2份。
进一步地,所述蛇床子提取物、百部提取物、青蒿提取物、牡丹皮提取物、莪术提取物、黄芪提取物、甘草提取物、卷柏提取物的制备方法为:
取中草药100g,加蒸馏水1000mL,浸泡2h,加热沸腾后继续煎煮30min,过滤中药药液。继续向药渣中加入等体积蒸馏水,用同样的方法煎煮1次,过滤,弃去药渣。合并2次煎煮液,离心,取上清液并将其浓缩至生药浓度50%,分装药液后121℃高压灭菌15min,即得各植物提取物。
进一步地,所述抑菌是指抑制大肠杆菌、白色念珠菌和金黄色葡萄球菌。
本发明上述任一所述组合物能够高效选择性抑制有害菌,同时不伤害有益菌,且所有组分均为天然植物成分,温和不刺激,可进一步用于女性私处护理产品。因此本发明还提供上述任一所述组合物在制备女性私处护理产品中的应用。所述女性私处护理产品包括但不限于女士慕斯泡泡、阴道凝胶、妇科阴道洗液等。
一种女性抑菌洗液,包括以下重量百分比的各组分:5~10%的上述任一所述组合物,20~30%表面活性剂,3~5%稳定剂,2~5%保湿剂、0.2~0.5%皮肤调理剂、0.2~0.5%pH调节剂,其余为纯化水。
优选地,所述表面活性剂为椰油酰谷氨酸钠、烷基葡糖苷、椰油酰胺丙基甜菜碱、椰油酰谷氨酸二钠中的任意一种或多种。
优选地,所述稳定剂为山梨醇。
优选地,所述保湿剂为甘油和/或透明质酸钠。
优选地,所述皮肤调理剂为甘油葡糖苷。
优选地,所述pH调节剂为柠檬酸和/或乳酸。
本发明还提供所述女性抑菌洗液的制备方法,包括如下步骤:
(1)将足量的水、甘油、透明质酸钠、山梨醇按照以上配比混合后,搅拌均匀。
(2)按照以上配比加入椰油酰谷氨酸钠、烷基葡糖苷、椰油酰胺丙基甜菜碱、椰油酰谷氨酸二钠,开始搅拌,并升温至80℃,继续搅拌30min。
(3)降温至40℃以下,按照以上配比加入甘油葡糖苷、抑菌组合物,搅拌均匀。
(4)按照以上配比添加柠檬酸或乳酸,调整pH为4.5~6.5,得到均匀、透明、淡黄色的液体。
与现有技术相比,本发明具有以下有益效果:
本发明研究表明,将蛇床子提取物、百部提取物、青蒿提取物、牡丹皮提取物、莪术提取物以一定配比组合使用时,其对常见的阴道有害菌,如白色念珠菌、大肠杆菌、金黄色葡萄球菌等具有较好的抑制效果,作用2min,抑菌效果可达80%以上,而对阴道有益菌,主要是乳酸杆菌,作用2min,抑菌率在40.0%左右;而在上述配方基础上再复配一定用量不具有抗菌作用的黄芪提取物和甘草提取物之后,得到的中药组合物对上述常见的阴道有害菌的抑菌效果又有提升,且对有益菌的抑菌率显著降低,降低到了5.0%以下,具有显著的协同增效作用。所述组合物的组分均为天然植物成分,温和不刺激,可进一步用于女性私处护理产品生产中。
附图说明
图1为本发明妇科抑菌洗液皮肤刺激性测试结果。
具体实施方式
以下结合说明书附图和具体实施例来进一步说明本发明,但实施例并不对本发明做任何形式的限定。除非特别说明,本发明采用的试剂、方法和设备为本技术领域常规试剂、方法和设备。
除非特别说明,以下实施例所用试剂和材料均为市购。
本发明所用的原料可通过自制获得或商业渠道购买。例如:蛇床子提取物购自于正禾(广州)生物科技有限公司、百部提取物购自于正禾(广州)生物科技有限公司、青蒿提取物购自于正禾(广州)生物科技有限公司、牡丹皮提取物购自于正禾(广州)生物科技有限公司、莪术提取物购自于正禾(广州)生物科技有限公司、黄芪提取物购自于正禾(广州)生物科技有限公司、甘草提取物购自于正禾(广州)生物科技有限公司、卷柏提取物购自于正禾(广州)生物科技有限公司、冰片购自于亳州金铭生物科技有限公司、菊粉购自于河南明合生物技术有限公司、α-葡聚糖寡糖购自于河南明合生物技术有限公司、石榴籽油购自于广州斯诺科生物科技有限公司、茉莉花油购自于广州斯诺科生物科技有限公司、白兰花精油购自于广州斯诺科生物科技有限公司。
所述蛇床子提取物、百部提取物、青蒿提取物、牡丹皮提取物、莪术提取物、黄芪提取物、甘草提取物、卷柏提取物的制备方法为:
取中草药100g,加蒸馏水1000mL,浸泡2h,加热沸腾后继续煎煮30min,过滤中药药液。继续向药渣中加入等体积蒸馏水,用同样的方法煎煮1次,过滤,弃去药渣。合并2次煎煮液,离心,取上清液并将其浓缩至生药浓度50%,分装药液后121℃高压灭菌15min,即得各植物提取物。
实施例1
一种具有抑菌止痒净味作用的组合物,包括以下重量的各组分:蛇床子提取物12克、百部提取物9克、青蒿提取物15克、牡丹皮提取物9克、莪术提取物9克、黄芪提取物10克、甘草提取物6克。
所述组合物的制备方法:将各植物提取物按重量比例混合,搅拌均匀,即得。
实施例2
一种具有抑菌止痒净味作用的组合物,包括以下重量的各组分:蛇床子提取物8克、百部提取物7克、青蒿提取物13克、牡丹皮提取物6克、莪术提取物9克、黄芪提取物6克、甘草提取物6克。
所述组合物的制备方法同实施例1。
实施例3
一种具有抑菌止痒净味作用的组合物,包括以下重量的各组分:蛇床子提取物10克、百部提取物11克、青蒿提取物14克、牡丹皮提取物8克、莪术提取物6克、黄芪提取物10克、甘草提取物3克。
所述组合物的制备方法同实施例1。
实施例4
一种具有抑菌止痒净味作用的组合物,包括以下重量的各组分:蛇床子提取物14克、百部提取物5克、青蒿提取物16克、牡丹皮提取物5克、莪术提取物5克、黄芪提取物12克、甘草提取物3克。
所述组合物的制备方法同实施例1。
实施例5
一种具有抑菌止痒净味作用的组合物,包括以下重量的各组分:蛇床子提取物6克、百部提取物13克、青蒿提取物10克、牡丹皮提取物10克、莪术提取物10克、黄芪提取物5克、甘草提取物8克。
所述组合物的制备方法同实施例1。
实施例6
一种具有抑菌止痒净味作用的组合物,包括以下重量的各组分:蛇床子提取物12克、百部提取物9克、青蒿提取物15克、牡丹皮提取物9克、莪术提取物9克、黄芪提取物10克、甘草提取物6克、卷柏提取物6克、冰片0.01克。
所述组合物的制备方法:将冰片按照1:100的比例溶于甘油后,再与其余各植物提取物按照一定比例混合,搅拌均匀。
实施例7
一种具有抑菌止痒净味作用的组合物,包括以下重量的各组分:蛇床子提取物12克、百部提取物9克、青蒿提取物15克、牡丹皮提取物9克、莪术提取物9克、黄芪提取物10克、甘草提取物6克、卷柏提取物3克、冰片0.005克。
所述组合物的制备方法同实施例6。
实施例8
一种具有抑菌止痒净味作用的组合物,包括以下重量的各组分:蛇床子提取物12克、百部提取物9克、青蒿提取物15克、牡丹皮提取物9克、莪术提取物9克、黄芪提取物10克、甘草提取物6克、卷柏提取物3克、冰片0.01克。
所述组合物的制备方法同实施例6。
实施例9
一种具有抑菌止痒净味作用的组合物,包括以下重量的各组分:蛇床子提取物12克、百部提取物9克、青蒿提取物15克、牡丹皮提取物9克、莪术提取物9克、黄芪提取物10克、甘草提取物6克、卷柏提取物6克、冰片0.01克、菊粉2克、α-葡聚糖寡糖0.5克。
所述组合物的制备方法:在实施例6的基础上,按照上述比例添加菊粉和α-葡聚糖寡糖,搅拌均匀。
实施例10
一种具有抑菌止痒净味作用的组合物,包括以下重量的各组分:蛇床子提取物12克、百部提取物9克、青蒿提取物15克、牡丹皮提取物9克、莪术提取物9克、黄芪提取物10克、甘草提取物6克、卷柏提取物6克、冰片0.01克、菊粉1克、α-葡聚糖寡糖0.2克。
所述组合物的制备方法同实施例9。
实施例11
一种具有抑菌止痒净味作用的组合物,包括以下重量的各组分:蛇床子提取物12克、百部提取物9克、青蒿提取物15克、牡丹皮提取物9克、莪术提取物9克、黄芪提取物10克、甘草提取物6克、卷柏提取物6克、冰片0.01克、菊粉1克、α-葡聚糖寡糖0.5克。
所述组合物的制备方法同实施例9。
实施例12
一种具有抑菌止痒净味作用的组合物,包括以下重量的各组分:蛇床子提取物12克、百部提取物9克、青蒿提取物15克、牡丹皮提取物9克、莪术提取物9克、黄芪提取物10克、甘草提取物6克、卷柏提取物6克、冰片0.01克、菊粉2克、α-葡聚糖寡糖0.5克、石榴籽油0.2克、茉莉花油0.2克、白兰花精油0.2克。
所述组合物的制备方法:在实施例9的基础上,将石榴籽油、茉莉花油、白兰花精油、按照1:10的比例与甘油混合溶解后,再与提取物按照比例混合,搅拌均匀。
实施例13
一种具有抑菌止痒净味作用的组合物,包括以下重量的各组分:蛇床子提取物12克、百部提取物9克、青蒿提取物15克、牡丹皮提取物9克、莪术提取物9克、黄芪提取物10克、甘草提取物6克、菊粉2克、α-葡聚糖寡糖0.5克、石榴籽油0.2克、茉莉花油0.2克、白兰花精油0.2克。
所述组合物的制备方法同实施例12。
实施例14
一种具有抑菌止痒净味作用的组合物,包括以下重量的各组分:蛇床子提取物12克、百部提取物9克、青蒿提取物15克、牡丹皮提取物9克、莪术提取物9克、黄芪提取物10克、甘草提取物6克、石榴籽油0.2克、茉莉花油0.2克、白兰花精油0.2克。
所述组合物的制备方法同实施例12。
对比例1
一种抑菌组合物,包括以下重量的各组分:蛇床子提取物12克、百部提取物9克、青蒿提取物15克、牡丹皮提取物9克、莪术提取物9克。
所述组合物的制备方法同实施例1
对比例2
一种抑菌组合物,包括以下重量的各组分:蛇床子提取物2克、百部提取物4克、青蒿提取物8克、牡丹皮提取物4克、莪术提取物4克、黄芪提取物13克、甘草提取物2克。
所述组合物的制备方法同实施例1。
对比例3
一种抑菌组合物,包括以下重量的各组分:蛇床子提取物15克、百部提取物3克、青蒿提取物9克、牡丹皮提取物3克、莪术提取物6克、黄芪提取物9克、甘草提取物6克。
所述组合物的制备方法同实施例1。
测试例1抗菌测试
测试方法:有害菌(大肠杆菌、白色念珠菌及金黄色葡萄球菌),有益菌(乳酸杆菌)的抑菌测试参照GB 15979-2022《一次性使用卫生用品卫生标准》附录C4的溶出性抗(抑)菌产品抑菌性能试验方法进行,试验样品为上述各实施例和对比例制得的抑菌组合物,以大肠杆菌ATCC-25922、金黄色葡萄球菌ATCC-6538、白色念珠菌ATCC-10231、鼠李糖乳杆菌2084为试验菌种,作用时间2min,每个样品重复三次,计算平均值。具体测试结果见表1。
表1抑菌液测试结果
注:GB15979-2002一次性使用卫生用品卫生标准,附录C4规定:抑菌率≥50~90%,产品有抑菌作用;抑菌率≥90%,产品有较强抑菌作用。
从表1可以看出,本发明的将蛇床子提取物、百部提取物、青蒿提取物、牡丹皮提取物、莪术提取物以一定配比组合使用时,其虽然对常见的阴道有害菌,如白色念珠菌、大肠杆菌、金黄色葡萄球菌等具有较好的快速抑制效果,作用2min,抑菌效果可达80%以上,但对阴道有益菌,主要是乳酸杆菌也具有一定的抑制作用,作用2min,抑菌率40.0%左右(对比例1);但在上述配方基础上再复配一定用量不具有抗菌作用的黄芪提取物和甘草提取物之后发现,中药组合物对上述常见的阴道有害菌的抑菌效果又有提升,且有益菌的抑菌率显著降低,降低到了5.0%以下(实施例1-5),具有显著的协同增效作用。同时在实施例1-5所述组合物之外再额外添加其它具有护肤或促渗透等成分均不会影响其抑菌效果(实施例6-14)。而当抑菌组合物的组分缺少黄芪提取物和甘草提取物(对比例1),或各组分用量不在实施例1-5的用量范围内时(对比例2-3),其对有害菌的抑菌效果会显著降低或对有益菌的抑菌效果会显著提高。表明本发明的组合物需要特定组分和配比才能可以实现对有害菌的快速抑制,同时不伤害有益菌。
实施例15
一种妇科抑菌洗液,包括如下重量百分比的各组分:10%实施例11所述组合物,30%表面活性剂,5%稳定剂,3%保湿剂、0.5%皮肤调理剂、0.5%pH调节剂,51%纯化水。
所述表面活性剂为9.0%椰油酰谷氨酸钠、8.0%烷基葡糖苷、7.0%椰油酰胺丙基甜菜碱、6.0%椰油酰谷氨酸二钠。
所述稳定剂为山梨醇。
所述保湿剂为2.5%甘油、0.5%透明质酸钠。
所述皮肤调理剂为甘油葡糖苷。
所述pH调节剂为柠檬酸。
所述妇科抑菌洗液的制备方法,包括如下步骤:
(1)将足量的水、甘油、透明质酸钠、山梨醇按照上述配比混合后,搅拌均匀。
(2)按照上述配比加入椰油酰谷氨酸钠、烷基葡糖苷、椰油酰胺丙基甜菜碱、椰油酰谷氨酸二钠,开始搅拌,并升温至80℃,继续搅拌30min。
(3)降温至40℃以下,按照上述配比加入甘油葡糖苷、抑菌组合物,搅拌均匀。
(4)按照比例添加柠檬酸,调整pH为4.5-6.5,得到均匀、透明、淡黄色的液体。
实施例16
一种妇科抑菌洗液,包括如下重量百分比的各组分:7%实施例11所述组合物,20%表面活性剂,5%稳定剂,3%保湿剂、0.2%皮肤调理剂、0.2%pH调节剂,64.6%纯化水。
所述表面活性剂为8.0%椰油酰谷氨酸钠、7.0%烷基葡糖苷、5.0%椰油酰胺丙基甜菜碱,稳定剂、保湿剂、皮肤调理剂的种类与实施例14相同,pH调节剂为乳酸。
所述妇科抑菌洗液的制备方法与实施例15相同。
实施例17
一种妇科抑菌洗液,包括如下重量百分比的各组分:5%实施例11所述化合物,15%表面活性剂,4%稳定剂,2%保湿剂、0.3%皮肤调理剂、0.4%pH调节剂,63.3%纯化水。
所述表面活性剂为.8.0%椰油酰谷氨酸二钠、5.0%烷基葡糖苷、2.0%椰油酰胺丙基甜菜碱,保湿剂为1.5%甘油、0.5%透明质酸钠,稳定剂、皮肤调理剂、pH调节剂的种类与实施例15相同。
所述妇科抑菌洗液的制备方法与实施例15相同。
测试例2妇科抑菌洗液测试
(1)抑菌效果测试
测试方法:参照GB 15979-2022《一次性使用卫生用品卫生标准》附录C4的溶出性抗(抑)菌产品抑菌性能试验方法进行,试验样品为上述各实施例和对比例制得的抑菌组合物,以大肠杆菌ATCC-25922、金黄色葡萄球菌ATCC-6538、白色念珠菌ATCC-10231、鼠李糖乳杆菌2084为试验菌种,作用时间2min,每个样品重复三次,计算平均值。具体测试结果见表2。
表2妇科抑菌洗液测试结果
从表2可以看出,本发明的妇科抑菌洗液在2min内对有害菌:大肠杆菌、白色念珠菌及金黄色葡萄球菌的抑菌率高,而对有益菌:乳酸杆菌不具有抑制效果。
(2)皮肤刺激性测试
委托中科检测技术服务(广州)股份有限公司进行皮肤刺激性测试。具体测试结果如图1所示,根据《消毒技术规范》2002年版中皮肤刺激强度分级标准,本发明妇科抑菌洗液对家兔多次完整皮肤刺激性试验结果为:无刺激性,符合《消毒技术规范》2002年版2.3.13.1的要求。
Claims (14)
1.一种具有抑菌止痒净味作用的组合物,其特征在于,由以下重量份数的各组分组成:蛇床子提取物6~14份、百部提取物5~13份、青蒿提取物10~16份、牡丹皮提取物5~10份、莪术提取物5~10份、黄芪提取物5~12份、甘草提取物3~8份。
2.根据权利要求1所述组合物,其特征在于,由以下重量份数的各组分组成:蛇床子提取物8~12份、百部提取物7~11份、青蒿提取物13~15份、牡丹皮提取物6~9份、莪术提取物6~9份、黄芪提取物6~10份、甘草提取物3~6份。
3.根据权利要求1或2所述组合物,其特征在于,由以下重量份数的各组分组成:蛇床子提取物12份、百部提取物9份、青蒿提取物15份、牡丹皮提取物9份、莪术提取物9份、黄芪提取物10份、甘草提取物6份。
4.一种具有抑菌止痒净味作用的组合物,其特征在于,由以下重量份数的各组分组成:蛇床子提取物6~14份、百部提取物5~13份、青蒿提取物10~16份、牡丹皮提取物5~10份、莪术提取物5~10份、黄芪提取物5~12份、甘草提取物3~8份、卷柏提取物3~6份。
5.一种具有抑菌止痒净味作用的组合物,其特征在于,由以下重量份数的各组分组成:蛇床子提取物6~14份、百部提取物5~13份、青蒿提取物10~16份、牡丹皮提取物5~10份、莪术提取物5~10份、黄芪提取物5~12份、甘草提取物3~8份、冰片0.005~0.01份。
6.一种具有抑菌止痒净味作用的组合物,其特征在于,由以下重量份数的各组分组成:蛇床子提取物6~14份、百部提取物5~13份、青蒿提取物10~16份、牡丹皮提取物5~10份、莪术提取物5~10份、黄芪提取物5~12份、甘草提取物3~8份、菊粉1~2份、α-葡聚糖寡糖0.2~0.5份。
7.一种具有抑菌止痒净味作用的组合物,其特征在于,由以下重量份数的各组分组成:蛇床子提取物6~14份、百部提取物5~13份、青蒿提取物10~16份、牡丹皮提取物5~10份、莪术提取物5~10份、黄芪提取物5~12份、甘草提取物3~8份、石榴籽油0.1~0.2份、茉莉花油0.1~0.2份、白兰花精油0.1~0.2份。
8.权利要求1~7任一所述组合物在制备女性私处护理产品中的应用。
9.一种女性抑菌洗液,其特征在于,包含以下重量百分比的各组分:5~10%的权利要求1~7任一所述组合物,20~30%表面活性剂,3~5%稳定剂,2~5%保湿剂、0.2~0.5%皮肤调理剂、0.2~0.5%pH调节剂,其余为纯化水。
10.根据权利要求9所述女性抑菌洗液,其特征在于,所述表面活性剂为椰油酰谷氨酸钠、烷基葡糖苷、椰油酰胺丙基甜菜碱、椰油酰谷氨酸二钠中的任意一种或多种。
11.根据权利要求9所述女性抑菌洗液,其特征在于,所述稳定剂为山梨醇。
12.根据权利要求9所述女性抑菌洗液,其特征在于,所述保湿剂为甘油和/或透明质酸钠。
13.根据权利要求9所述女性抑菌洗液,其特征在于,所述皮肤调理剂为甘油葡糖苷。
14.根据权利要求9所述女性抑菌洗液,其特征在于,所述pH调节剂为柠檬酸和/或乳酸。
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